Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PGLYRP3 Gene

Aliases for PGLYRP3 Gene

  • Peptidoglycan Recognition Protein 3 2 3 5
  • Peptidoglycan Recognition Protein Intermediate Alpha 3 4
  • PGLYRPIalpha 3 4
  • PGRPIA 3 4
  • Peptidoglycan Recognition Protein I Alpha Precursor 2
  • Peptidoglycan Recognition Protein I Alpha 3
  • Peptidoglycan Recognition Protein I-Alpha 4
  • PGRP-I-Alpha 4
  • PGRP-Ialpha 3

External Ids for PGLYRP3 Gene

Previous GeneCards Identifiers for PGLYRP3 Gene

  • GC01M150487
  • GC01M150083
  • GC01M151536
  • GC01M124633

Summaries for PGLYRP3 Gene

Entrez Gene Summary for PGLYRP3 Gene

  • This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]

GeneCards Summary for PGLYRP3 Gene

PGLYRP3 (Peptidoglycan Recognition Protein 3) is a Protein Coding gene. Diseases associated with PGLYRP3 include High Pressure Neurological Syndrome and Reflex Epilepsy. GO annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP1.

UniProtKB/Swiss-Prot for PGLYRP3 Gene

  • Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGLYRP3 Gene

Genomics for PGLYRP3 Gene

Regulatory Elements for PGLYRP3 Gene

Enhancers for PGLYRP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PGLYRP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PGLYRP3 Gene

Chromosome:
1
Start:
153,297,589 bp from pter
End:
153,312,975 bp from pter
Size:
15,387 bases
Orientation:
Minus strand

Genomic View for PGLYRP3 Gene

Genes around PGLYRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLYRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLYRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLYRP3 Gene

Proteins for PGLYRP3 Gene

  • Protein details for PGLYRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB9-PGRP3_HUMAN
    Recommended name:
    Peptidoglycan recognition protein 3
    Protein Accession:
    Q96LB9
    Secondary Accessions:
    • A1A4U8
    • Q5SY65

    Protein attributes for PGLYRP3 Gene

    Size:
    341 amino acids
    Molecular mass:
    37611 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for PGLYRP3 Gene

neXtProt entry for PGLYRP3 Gene

Proteomics data for PGLYRP3 Gene at MOPED

Post-translational modifications for PGLYRP3 Gene

Other Protein References for PGLYRP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PGLYRP3 Gene

Domains & Families for PGLYRP3 Gene

Protein Domains for PGLYRP3 Gene

Suggested Antigen Peptide Sequences for PGLYRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LB9

UniProtKB/Swiss-Prot:

PGRP3_HUMAN :
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Family:
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
genes like me logo Genes that share domains with PGLYRP3: view

No data available for Gene Families for PGLYRP3 Gene

Function for PGLYRP3 Gene

Molecular function for PGLYRP3 Gene

UniProtKB/Swiss-Prot Function:
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by exposure to Gram-positive and Gram-negative bacteria.

Gene Ontology (GO) - Molecular Function for PGLYRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042834 peptidoglycan binding IDA 11461926
genes like me logo Genes that share ontologies with PGLYRP3: view
genes like me logo Genes that share phenotypes with PGLYRP3: view

Animal Models for PGLYRP3 Gene

MGI Knock Outs for PGLYRP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PGLYRP3 Gene

Localization for PGLYRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLYRP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGLYRP3 Gene COMPARTMENTS Subcellular localization image for PGLYRP3 gene
Compartment Confidence
extracellular 4
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PGLYRP3 Gene

Pathways & Interactions for PGLYRP3 Gene

SuperPathways for PGLYRP3 Gene

No Data Available

Interacting Proteins for PGLYRP3 Gene

Selected Interacting proteins: Q96LB9-PGRP3_HUMAN for PGLYRP3 Gene via I2D

Symbol External ID(s) Details
PGLYRP4

Gene Ontology (GO) - Biological Process for PGLYRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009253 peptidoglycan catabolic process IEA --
GO:0032827 negative regulation of natural killer cell differentiation involved in immune response IEA --
GO:0044117 growth of symbiont in host IEA --
GO:0050830 defense response to Gram-positive bacterium IDA 11461926
genes like me logo Genes that share ontologies with PGLYRP3: view

No data available for Pathways by source and SIGNOR curated interactions for PGLYRP3 Gene

Drugs & Compounds for PGLYRP3 Gene

(2) Drugs for PGLYRP3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Alanine Approved Nutra Full agonist, Agonist Glycine receptor agonist 0
2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE Experimental Pharma Target 0

(3) Additional Compounds for PGLYRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylmuramate
N-Acetylmuramoyl-Ala
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PGLYRP3: view

Transcripts for PGLYRP3 Gene

mRNA/cDNA for PGLYRP3 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGLYRP3 Gene

Peptidoglycan recognition protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGLYRP3 Gene

No ASD Table

Relevant External Links for PGLYRP3 Gene

GeneLoc Exon Structure for
PGLYRP3
ECgene alternative splicing isoforms for
PGLYRP3

Expression for PGLYRP3 Gene

mRNA expression in normal human tissues for PGLYRP3 Gene

mRNA differential expression in normal tissues according to GTEx for PGLYRP3 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.2), Skin - Sun Exposed (Lower leg) (x12.4), Skin - Not Sun Exposed (Suprapubic) (x11.5), Vagina (x8.0), and Cervix - Ectocervix (x5.3).

Protein differential expression in normal tissues from HIPED for PGLYRP3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PGLYRP3 Gene



SOURCE GeneReport for Unigene cluster for PGLYRP3 Gene Hs.348266

mRNA Expression by UniProt/SwissProt for PGLYRP3 Gene

Q96LB9-PGRP3_HUMAN
Tissue specificity: Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.
genes like me logo Genes that share expression patterns with PGLYRP3: view

Protein tissue co-expression partners for PGLYRP3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PGLYRP3 Gene

Orthologs for PGLYRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGLYRP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGLYRP3 35
  • 84.32 (n)
  • 79.13 (a)
PGLYRP3 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pglyrp3 35
  • 79.92 (n)
  • 74.18 (a)
Pglyrp3 16
Pglyrp3 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGLYRP3 35
  • 99.53 (n)
  • 99.64 (a)
PGLYRP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pglyrp3 35
  • 79.9 (n)
  • 74.33 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pglyrp5 36
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta PGRP-LF 35
  • 49.17 (n)
  • 41.87 (a)
PGRP-LB 36
  • 27 (a)
ManyToMany
PGRP-SA 36
  • 37 (a)
ManyToMany
PGRP-SB1 36
  • 40 (a)
ManyToMany
PGRP-SB2 36
  • 30 (a)
ManyToMany
PGRP-SC1a 36
  • 33 (a)
ManyToMany
PGRP-SC1b 36
  • 33 (a)
ManyToMany
PGRP-SC2 36
  • 34 (a)
ManyToMany
PGRP-SD 36
  • 37 (a)
ManyToMany
Species with no ortholog for PGLYRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGLYRP3 Gene

ENSEMBL:
Gene Tree for PGLYRP3 (if available)
TreeFam:
Gene Tree for PGLYRP3 (if available)

Paralogs for PGLYRP3 Gene

Paralogs for PGLYRP3 Gene

(2) SIMAP similar genes for PGLYRP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PGLYRP3: view

Variants for PGLYRP3 Gene

Sequence variations from dbSNP and Humsavar for PGLYRP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs843971 - 153,304,947(-) AGATA(A/G)GTAAG nc-transcript-variant, reference, missense
rs55991125 - 153,307,220(+) GCAGG(C/T)GAGCG nc-transcript-variant, reference, missense
rs821416 -- 153,314,890(-) ttaca(C/G)tgttg upstream-variant-2KB
rs821417 -- 153,312,092(-) GCACA(A/G)TGATT intron-variant, upstream-variant-2KB
rs821418 -- 153,311,947(-) TTCCT(C/T)ATATT intron-variant, upstream-variant-2KB

Variation tolerance for PGLYRP3 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.37; 97.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGLYRP3 Gene

Human Gene Mutation Database (HGMD)
PGLYRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PGLYRP3 Gene

Disorders for PGLYRP3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PGLYRP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
high pressure neurological syndrome
reflex epilepsy
  • epilepsy, sensory-induced
progressive relapsing multiple sclerosis
  • prms
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PGLYRP3

Genetic Association Database (GAD)
PGLYRP3
Human Genome Epidemiology (HuGE) Navigator
PGLYRP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGLYRP3
genes like me logo Genes that share disorders with PGLYRP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGLYRP3 Gene

Publications for PGLYRP3 Gene

  1. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. (PMID: 11461926) Liu C. … Dziarski R. (J. Biol. Chem. 2001) 2 3 4 67
  2. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. (PMID: 16354652) Lu X. … Dziarski R. (J. Biol. Chem. 2006) 3 23
  3. Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria. (PMID: 16641493) Guan R. … Mariuzza R.A. (Protein Sci. 2006) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Peptidoglycan recognition protein 3 (PglyRP3) has an anti-inflammatory role in intestinal epithelial cells. (PMID: 22099350) Zenhom M. … Schrezenmeir J. (Immunobiology 2012) 3

Products for PGLYRP3 Gene

Sources for PGLYRP3 Gene

Content