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Aliases for PGLYRP3 Gene

Aliases for PGLYRP3 Gene

  • Peptidoglycan Recognition Protein 3 2 3 5
  • Peptidoglycan Recognition Protein Intermediate Alpha 3 4
  • PGLYRPIalpha 3 4
  • PGRPIA 3 4
  • Peptidoglycan Recognition Protein I Alpha Precursor 2
  • Peptidoglycan Recognition Protein I Alpha 3
  • Peptidoglycan Recognition Protein I-Alpha 4
  • PGRP-I-Alpha 4
  • PGRP-Ialpha 3

External Ids for PGLYRP3 Gene

Previous GeneCards Identifiers for PGLYRP3 Gene

  • GC01M150487
  • GC01M150083
  • GC01M151536
  • GC01M124633

Summaries for PGLYRP3 Gene

Entrez Gene Summary for PGLYRP3 Gene

  • This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]

GeneCards Summary for PGLYRP3 Gene

PGLYRP3 (Peptidoglycan Recognition Protein 3) is a Protein Coding gene. Diseases associated with PGLYRP3 include High Pressure Neurological Syndrome and Reflex Epilepsy. Among its related pathways are Immune System. GO annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP4.

UniProtKB/Swiss-Prot for PGLYRP3 Gene

  • Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGLYRP3 Gene

Genomics for PGLYRP3 Gene

Regulatory Elements for PGLYRP3 Gene

Enhancers for PGLYRP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F153373 1 Ensembl ENCODE 10.1 -62.0 -62006 3.6 CTCF HDGF JUN CEBPG ZNF664 GATA3 POLR2A EED SMARCC2 FOS PGLYRP4 RNU6-160P PGLYRP3 S100A12 S100A9
GH01F153489 0.8 Ensembl ENCODE 9.8 -177.9 -177853 2.1 SIN3A FEZF1 ZNF2 FOS DEK SP3 REST TSHZ1 ZNF518A ZNF623 PGLYRP4 S100A9 RNU6-160P S100A1 CHTOP S100A13 PGLYRP3 RN7SL44P S100A3 GC01M153500
GH01F153488 0.6 Ensembl 9.8 -175.9 -175926 0.2 PGLYRP4 S100A9 RNU6-160P S100A1 CHTOP S100A13 PGLYRP3 RN7SL44P GC01M153500 S100A7
GH01F153344 0.5 Ensembl ENCODE 9.1 -31.9 -31894 3.9 HDGF ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 ELK1 GATA2 KLF13 NCOA1 PGLYRP4 ENSG00000272654 INTS3 S100A6 PGLYRP3 RNU6-160P
GH01F153577 1.6 FANTOM5 Ensembl ENCODE 3.7 -265.4 -265385 2.7 CTCF KLF1 JUN KLF17 ZIC2 ZNF664 FOSL1 ZNF121 ZFHX2 GATA3 S100A3 S100A16 S100A14 S100A1 S100A13 CHTOP S100A7L2 SNAPIN ILF2 NPR1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PGLYRP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PGLYRP3 Gene

Chromosome:
1
Start:
153,297,589 bp from pter
End:
153,312,975 bp from pter
Size:
15,387 bases
Orientation:
Minus strand

Genomic View for PGLYRP3 Gene

Genes around PGLYRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLYRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLYRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLYRP3 Gene

Proteins for PGLYRP3 Gene

  • Protein details for PGLYRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB9-PGRP3_HUMAN
    Recommended name:
    Peptidoglycan recognition protein 3
    Protein Accession:
    Q96LB9
    Secondary Accessions:
    • A1A4U8
    • Q5SY65

    Protein attributes for PGLYRP3 Gene

    Size:
    341 amino acids
    Molecular mass:
    37611 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked. Heterodimer with PGLYRP4; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for PGLYRP3 Gene

neXtProt entry for PGLYRP3 Gene

Post-translational modifications for PGLYRP3 Gene

Other Protein References for PGLYRP3 Gene

No data available for DME Specific Peptides for PGLYRP3 Gene

Domains & Families for PGLYRP3 Gene

Protein Domains for PGLYRP3 Gene

Suggested Antigen Peptide Sequences for PGLYRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LB9

UniProtKB/Swiss-Prot:

PGRP3_HUMAN :
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Family:
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
genes like me logo Genes that share domains with PGLYRP3: view

No data available for Gene Families for PGLYRP3 Gene

Function for PGLYRP3 Gene

Molecular function for PGLYRP3 Gene

UniProtKB/Swiss-Prot Function:
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by exposure to Gram-positive and Gram-negative bacteria.

Gene Ontology (GO) - Molecular Function for PGLYRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity IEA --
GO:0016019 peptidoglycan receptor activity IDA 11461926
GO:0042834 peptidoglycan binding IDA 11461926
genes like me logo Genes that share ontologies with PGLYRP3: view
genes like me logo Genes that share phenotypes with PGLYRP3: view

Animal Models for PGLYRP3 Gene

MGI Knock Outs for PGLYRP3:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PGLYRP3 Gene

Localization for PGLYRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLYRP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGLYRP3 Gene COMPARTMENTS Subcellular localization image for PGLYRP3 gene
Compartment Confidence
extracellular 4
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PGLYRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005622 intracellular NAS 11461926
GO:0016020 membrane NAS 11461926
genes like me logo Genes that share ontologies with PGLYRP3: view

Pathways & Interactions for PGLYRP3 Gene

SuperPathways for PGLYRP3 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with PGLYRP3: view

Pathways by source for PGLYRP3 Gene

2 Reactome pathways for PGLYRP3 Gene

Interacting Proteins for PGLYRP3 Gene

Selected Interacting proteins: Q96LB9-PGRP3_HUMAN for PGLYRP3 Gene via IID

Gene Ontology (GO) - Biological Process for PGLYRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002221 pattern recognition receptor signaling pathway IEA --
GO:0002376 immune system process IEA --
GO:0009253 peptidoglycan catabolic process IEA --
GO:0016045 detection of bacterium IDA 11461926
GO:0032689 negative regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with PGLYRP3: view

No data available for SIGNOR curated interactions for PGLYRP3 Gene

Drugs & Compounds for PGLYRP3 Gene

(3) Drugs for PGLYRP3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
L-Alanine Approved Nutra Full agonist, Agonist Glycine receptor agonist 0
2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE Experimental Pharma Target 0

(2) Additional Compounds for PGLYRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylmuramate
N-Acetylmuramoyl-Ala
genes like me logo Genes that share compounds with PGLYRP3: view

Transcripts for PGLYRP3 Gene

mRNA/cDNA for PGLYRP3 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGLYRP3 Gene

Peptidoglycan recognition protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGLYRP3 Gene

No ASD Table

Relevant External Links for PGLYRP3 Gene

GeneLoc Exon Structure for
PGLYRP3
ECgene alternative splicing isoforms for
PGLYRP3

Expression for PGLYRP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PGLYRP3 Gene

mRNA differential expression in normal tissues according to GTEx for PGLYRP3 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.2), Skin - Sun Exposed (Lower leg) (x12.4), Skin - Not Sun Exposed (Suprapubic) (x11.5), Vagina (x8.0), and Cervix - Ectocervix (x5.3).

Protein differential expression in normal tissues from HIPED for PGLYRP3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PGLYRP3 Gene



Protein tissue co-expression partners for PGLYRP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PGLYRP3 Gene:

PGLYRP3

SOURCE GeneReport for Unigene cluster for PGLYRP3 Gene:

Hs.348266

mRNA Expression by UniProt/SwissProt for PGLYRP3 Gene:

Q96LB9-PGRP3_HUMAN
Tissue specificity: Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.
genes like me logo Genes that share expression patterns with PGLYRP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PGLYRP3 Gene

Orthologs for PGLYRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGLYRP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGLYRP3 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia PGLYRP3 34 35
  • 84.32 (n)
mouse
(Mus musculus)
Mammalia Pglyrp3 34 16 35
  • 79.92 (n)
rat
(Rattus norvegicus)
Mammalia Pglyrp3 34
  • 79.9 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pglyrp5 35
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta PGRP-LF 34
  • 49.17 (n)
PGRP-SB1 35
  • 40 (a)
ManyToMany
PGRP-SA 35
  • 37 (a)
ManyToMany
PGRP-SD 35
  • 37 (a)
ManyToMany
PGRP-SC2 35
  • 34 (a)
ManyToMany
PGRP-SC1a 35
  • 33 (a)
ManyToMany
PGRP-SC1b 35
  • 33 (a)
ManyToMany
PGRP-SB2 35
  • 30 (a)
ManyToMany
PGRP-LB 35
  • 27 (a)
ManyToMany
Species where no ortholog for PGLYRP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGLYRP3 Gene

ENSEMBL:
Gene Tree for PGLYRP3 (if available)
TreeFam:
Gene Tree for PGLYRP3 (if available)

Paralogs for PGLYRP3 Gene

Paralogs for PGLYRP3 Gene

(2) SIMAP similar genes for PGLYRP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PGLYRP3: view

Variants for PGLYRP3 Gene

Sequence variations from dbSNP and Humsavar for PGLYRP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10554939 -- 153,309,002(+) CACAC(-/AT)GTCTT intron-variant, utr-variant-5-prime
rs111260082 -- 153,301,026(+) CCTCC(A/G)TTTCA intron-variant
rs111267873 -- 153,314,539(+) TCCTT(A/C)ATCCA upstream-variant-2KB
rs111658704 -- 153,302,301(+) TGGAA(A/G)CCACC intron-variant
rs111725331 -- 153,304,607(+) CAGTG(A/G)AACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGLYRP3 Gene

Variant ID Type Subtype PubMed ID
nsv999024 CNV loss 25217958

Variation tolerance for PGLYRP3 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.37; 97.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGLYRP3 Gene

Human Gene Mutation Database (HGMD)
PGLYRP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGLYRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGLYRP3 Gene

Disorders for PGLYRP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PGLYRP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
high pressure neurological syndrome
reflex epilepsy
  • epilepsy, sensory-induced
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PGLYRP3

Genetic Association Database (GAD)
PGLYRP3
Human Genome Epidemiology (HuGE) Navigator
PGLYRP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGLYRP3
genes like me logo Genes that share disorders with PGLYRP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGLYRP3 Gene

Publications for PGLYRP3 Gene

  1. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. (PMID: 16354652) Lu X. … Dziarski R. (J. Biol. Chem. 2006) 3 4 22 64
  2. Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria. (PMID: 16641493) Guan R. … Mariuzza R.A. (Protein Sci. 2006) 3 4 22 64
  3. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. (PMID: 11461926) Liu C. … Dziarski R. (J. Biol. Chem. 2001) 2 3 4 64
  4. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PMID: 19601998) Stemmler S. … Hoffjan S. (Int. J. Immunogenet. 2009) 3 46 64
  5. Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha. (PMID: 15140887) Guan R. … Mariuzza R.A. (J. Biol. Chem. 2004) 3 4 64

Products for PGLYRP3 Gene

Sources for PGLYRP3 Gene

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