Aliases for PGLYRP3 Gene
External Ids for PGLYRP3 Gene
Previous GeneCards Identifiers for PGLYRP3 Gene
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
GeneCards Summary for PGLYRP3 Gene
PGLYRP3 (Peptidoglycan Recognition Protein 3) is a Protein Coding gene. Diseases associated with PGLYRP3 include High Pressure Neurological Syndrome and Reflex Epilepsy. GO annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP1.
UniProtKB/Swiss-Prot for PGLYRP3 Gene
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.