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Aliases for PGLYRP1 Gene

Aliases for PGLYRP1 Gene

  • Peptidoglycan Recognition Protein 1 2 3 5
  • TNFSF3L 3 4
  • PGLYRP 3 4
  • PGRP-S 3 4
  • PGRP 3 4
  • TNF Superfamily, Member 3 (LTB)-Like (Peptidoglycan Recognition Protein) 3
  • Peptidoglycan Recognition Protein Short 4
  • Peptidoglycan Recognition Protein 2
  • PGRPS 3
  • TAG7 3

External Ids for PGLYRP1 Gene

Previous HGNC Symbols for PGLYRP1 Gene

  • TNFSF3L
  • PGLYRP

Previous GeneCards Identifiers for PGLYRP1 Gene

  • GC19M051215
  • GC19M051216
  • GC19M046522
  • GC19M042950

Summaries for PGLYRP1 Gene

GeneCards Summary for PGLYRP1 Gene

PGLYRP1 (Peptidoglycan Recognition Protein 1) is a Protein Coding gene. Among its related pathways are TNF Signaling (sino). GO annotations related to this gene include peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. An important paralog of this gene is PGLYRP4.

UniProtKB/Swiss-Prot for PGLYRP1 Gene

  • Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

Gene Wiki entry for PGLYRP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGLYRP1 Gene

Genomics for PGLYRP1 Gene

Regulatory Elements for PGLYRP1 Gene

Enhancers for PGLYRP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PGLYRP1 on UCSC Golden Path with GeneCards custom track

Promoters for PGLYRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PGLYRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PGLYRP1 Gene

Chromosome:
19
Start:
46,019,153 bp from pter
End:
46,023,298 bp from pter
Size:
4,146 bases
Orientation:
Minus strand

Genomic View for PGLYRP1 Gene

Genes around PGLYRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLYRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLYRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLYRP1 Gene

Proteins for PGLYRP1 Gene

  • Protein details for PGLYRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75594-PGRP1_HUMAN
    Recommended name:
    Peptidoglycan recognition protein 1
    Protein Accession:
    O75594
    Secondary Accessions:
    • Q4VB36

    Protein attributes for PGLYRP1 Gene

    Size:
    196 amino acids
    Molecular mass:
    21731 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for PGLYRP1 Gene

neXtProt entry for PGLYRP1 Gene

Proteomics data for PGLYRP1 Gene at MOPED

Post-translational modifications for PGLYRP1 Gene

  • N-glycosylated. N-glycosylation is required for bactericidal activity.
  • Glycosylation at Asn 112
  • Modification sites at PhosphoSitePlus

Other Protein References for PGLYRP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PGLYRP1 (PGLYRP1/PGRP-S)

No data available for DME Specific Peptides for PGLYRP1 Gene

Domains & Families for PGLYRP1 Gene

Suggested Antigen Peptide Sequences for PGLYRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75594

UniProtKB/Swiss-Prot:

PGRP1_HUMAN :
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Family:
  • Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
genes like me logo Genes that share domains with PGLYRP1: view

No data available for Gene Families for PGLYRP1 Gene

Function for PGLYRP1 Gene

Molecular function for PGLYRP1 Gene

UniProtKB/Swiss-Prot Function:
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

Gene Ontology (GO) - Molecular Function for PGLYRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042834 peptidoglycan binding IDA 11461926
genes like me logo Genes that share ontologies with PGLYRP1: view
genes like me logo Genes that share phenotypes with PGLYRP1: view

Animal Models for PGLYRP1 Gene

MGI Knock Outs for PGLYRP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PGLYRP1

CRISPR Products

miRNA for PGLYRP1 Gene

miRTarBase miRNAs that target PGLYRP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PGLYRP1 Gene

Localization for PGLYRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLYRP1 Gene

Secreted. Cytoplasmic granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGLYRP1 Gene COMPARTMENTS Subcellular localization image for PGLYRP1 gene
Compartment Confidence
extracellular 5
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PGLYRP1 Gene

Pathways & Interactions for PGLYRP1 Gene

SuperPathways for PGLYRP1 Gene

Superpath Contained pathways
1 TNF Signaling (sino)
genes like me logo Genes that share pathways with PGLYRP1: view

Pathways by source for PGLYRP1 Gene

2 Sino Biological pathways for PGLYRP1 Gene

Interacting Proteins for PGLYRP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000008938%0d%0a9606.ENSP00000255631%0d%0a
Selected Interacting proteins: O75594-PGRP1_HUMAN ENSP00000008938 for PGLYRP1 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for PGLYRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9707603
GO:0009253 peptidoglycan catabolic process IEA --
GO:0016045 detection of bacterium IDA 11461926
GO:0032689 negative regulation of interferon-gamma production IEA --
GO:0032827 negative regulation of natural killer cell differentiation involved in immune response IEA --
genes like me logo Genes that share ontologies with PGLYRP1: view

No data available for SIGNOR curated interactions for PGLYRP1 Gene

Drugs & Compounds for PGLYRP1 Gene

(5) Drugs for PGLYRP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Alanine Approved Nutra Full agonist, Agonist Glycine receptor agonist 0

(7) Additional Compounds for PGLYRP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylmuramate
N-Acetylmuramoyl-Ala
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PGLYRP1: view

Transcripts for PGLYRP1 Gene

mRNA/cDNA for PGLYRP1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGLYRP1 Gene

Peptidoglycan recognition protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGLYRP1 Gene

No ASD Table

Relevant External Links for PGLYRP1 Gene

GeneLoc Exon Structure for
PGLYRP1
ECgene alternative splicing isoforms for
PGLYRP1

Expression for PGLYRP1 Gene

mRNA expression in normal human tissues for PGLYRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGLYRP1 Gene

This gene is overexpressed in Whole Blood (x49.2).

Protein differential expression in normal tissues from HIPED for PGLYRP1 Gene

This gene is overexpressed in Urine (28.4), Lavage (22.4), and Neutrophil (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PGLYRP1 Gene



SOURCE GeneReport for Unigene cluster for PGLYRP1 Gene Hs.137583

mRNA Expression by UniProt/SwissProt for PGLYRP1 Gene

O75594-PGRP1_HUMAN
Tissue specificity: Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils.
genes like me logo Genes that share expression patterns with PGLYRP1: view

Protein tissue co-expression partners for PGLYRP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PGLYRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGLYRP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGLYRP1 35
  • 77.58 (n)
  • 72.73 (a)
PGLYRP1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGLYRP1 35
  • 78.05 (n)
  • 69.51 (a)
PGLYRP1 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pglyrp1 35
  • 75.64 (n)
  • 69.78 (a)
Pglyrp1 16
Pglyrp1 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGLYRP1 35
  • 97.68 (n)
  • 95.19 (a)
PGLYRP1 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pglyrp1 35
  • 73.44 (n)
  • 67.58 (a)
oppossum
(Monodelphis domestica)
Mammalia PGLYRP1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGLYRP1 36
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pglyrp5 35
  • 47.93 (n)
  • 41.18 (a)
pglyrp5 36
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta PGRP-LB 36
  • 23 (a)
ManyToMany
PGRP-SA 36
  • 34 (a)
ManyToMany
PGRP-SB1 36
  • 33 (a)
ManyToMany
PGRP-SB2 36
  • 27 (a)
ManyToMany
PGRP-SC1a 36
  • 42 (a)
ManyToMany
PGRP-SC1b 36
  • 42 (a)
ManyToMany
PGRP-SC2 36
  • 40 (a)
ManyToMany
PGRP-SD 36
  • 34 (a)
ManyToMany
Species with no ortholog for PGLYRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGLYRP1 Gene

ENSEMBL:
Gene Tree for PGLYRP1 (if available)
TreeFam:
Gene Tree for PGLYRP1 (if available)

Paralogs for PGLYRP1 Gene

Paralogs for PGLYRP1 Gene

(3) SIMAP similar genes for PGLYRP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PGLYRP1: view

Variants for PGLYRP1 Gene

Sequence variations from dbSNP and Humsavar for PGLYRP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_050497 -
rs13343537 -- 46,019,575(+) CATAA(A/G/T)TGACC reference, missense
rs140248371 -- 46,020,426(+) TCTTA(C/T)CATCC intron-variant
rs73570785 -- 46,020,959(+) GGAGC(C/T)TGGCA intron-variant
rs141058051 -- 46,019,881(+) GCAAC(C/T)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGLYRP1 Gene

Variant ID Type Subtype PubMed ID
nsv912175 CNV Loss 21882294
nsv912176 CNV Gain 21882294

Variation tolerance for PGLYRP1 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGLYRP1 Gene

HapMap Linkage Disequilibrium report
PGLYRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGLYRP1 Gene

Disorders for PGLYRP1 Gene

Relevant External Links for PGLYRP1

Genetic Association Database (GAD)
PGLYRP1
Human Genome Epidemiology (HuGE) Navigator
PGLYRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGLYRP1

No disorders were found for PGLYRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGLYRP1 Gene

Publications for PGLYRP1 Gene

  1. A peptidoglycan recognition protein in innate immunity conserved from insects to humans. (PMID: 9707603) Kang D. … Steiner H. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. [Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells]. (PMID: 12669421) Kibardin A.V. … Kiselev S.L. (Genetika 2003) 2 3 23
  3. The association between peptidoglycan recognition protein-1 and coronary and peripheral atherosclerosis: Observations from the Dallas Heart Study. (PMID: 18774573) Rohatgi A. … de Lemos J.A. (Atherosclerosis 2009) 3 23
  4. Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. (PMID: 17502600) Cho S. … Mariuzza R.A. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  5. Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity. (PMID: 15956276) Cho J.H. … Ezekowitz R.A. (Blood 2005) 3 23

Products for PGLYRP1 Gene

Sources for PGLYRP1 Gene

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