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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGLS Gene

protein-coding   GIFtS: 57
GCID: GC19P017622

6-phosphogluconolactonase
 Explore 5 diseases affiliated with
PGLS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PGLS    

Aliases
for PGLS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
6-Phosphogluconolactonase1
6PGL1 2 3
EC 3.1.1.313 8

External Ids:    HGNC: 89031   Entrez Gene: 257962   Ensembl: ENSG000001303137   OMIM: 6049515   UniProtKB: O953363   

Export aliases for PGLS gene to outside databases

Previous GC identifers: GC19P018116 GC19P018014 GC19P017467 GC19P017484 GC19P017485 GC19P017486 GC19P017189


Summaries
for PGLS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336
Function: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate




Genomic Views
for PGLS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGLS gene promoter:
         Lmo2   STAT5A   CUTL1   E47   Arnt   HEN1   AREB6   PPAR-gamma1   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PGLS promoter sequence
   Search SABiosciences Chromatin IP Primers for PGLS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2

PGLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGLS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017622:  view genomic region     (about GC identifiers)

Start:
 17,622,432 bp from pter      End:
 17,632,097 bp from pter
Size:
 9,666 bases      Orientation:
 plus strand

Proteins
for PGLS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336 (See protein sequence)
Recommended Name: 6-phosphogluconolactonase  
Size: 258 amino acids; 27547 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAC72960.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for PGLS: NX_O95336

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95336

    • 4 DME Specific Peptides for PGLS (O95336)
     VATGEGKAA  DGHTCSLFP  FCDERLVPF  HPLLQEREKIVAPI 

    PGLS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036220.1  
    ENSEMBL proteins: 
     ENSP00000252603  
    Reactome Protein details: O95336
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: PGLS
    OriGene Protein Over-expression Lysate: PGLS
    OriGene Custom Protein Services for PGLS 
    GenScript Custom Purified and Recombinant Proteins Services for PGLS
    Novus Biologicals PGLS Proteins
    Novus Biologicals PGLS Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PGLS
    Uscn Proteins for PGLS

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005829cytosol TAS--


    PGLS for ontologies           About GeneDecksing



    PGLS Antibody Products: 
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    Novus Biologicals PGLS Antibodies
    Abcam antibodies for PGLS 
    Uscn Antibodies for PGLS
    Search ThermoFisher Antibodies for PGLS

    Assay Products for PGLS: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for PGLS

    Protein Domains /
    Families
    for PGLS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PGLS for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006148 Glc/Gal-6P_isomerase
     IPR005900 6-phosphogluconolactonase_DevB

    Graphical View of Domain Structure for InterPro Entry O95336

    ProtoNet protein and cluster: O95336

    UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336
    Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily


    Function
    for PGLS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336
    Function: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
    Catalytic activity: 6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate

         Genatlas biochemistry entry for PGLS:
    6-phosphogluconolactonase,cytosolic,catalyzing the second step of the pentose-phosphate pathway

    Enzyme Number (IUBMB): EC 3.1.1.311 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGLS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PGLS:
    hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmid: PGLS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PGLS (see all 4)
    OriGene shRNA RFP: PGLS
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGLS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PGLS

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PGLS (NM_012088)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGLS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGLS 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PGLS
    Search LifeMap BioReagents cell lines for PGLS

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PGLS

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00170576-phosphogluconolactonase activity IDA10518023
    GO:0048029monosaccharide binding IEA--


    PGLS for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PGLS:
     Cell cycle / mitosis defect  Synthetic lethal with imatinib 


    Pathways & Interactions
    for PGLS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pentose phosphate pathway (hexose monophosphate shunt)
    		Pentose phosphate pathway (hexose monophosphate shunt)1.00
    		pentose phosphate pathway0.67
    		Pentose Phosphate Pathway0.88
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Pentose Phosphate Pathway (Erythrocyte)
    		Pentose Phosphate Pathway (Erythrocyte)1.00
    		pentose phosphate pathway (oxidative branch)0.60
    4Pentose phosphate pathway
    		Pentose phosphate pathway1.00
    5MPS IIIC - Sanfilippo syndrome C
    		Metabolism of carbohydrates0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for PGLS 
        pentose phosphate pathway (oxidative branch)
    pentose phosphate pathway
    Pentose Phosphate Pathway

    3        Reactome Pathways for PGLS
        Metabolism of carbohydrates
    Pentose phosphate pathway (hexose monophosphate shunt)
    Metabolism

    1 PharmGKB Pathway for PGLS
        Pentose Phosphate Pathway (Erythrocyte)

    2         Kegg Pathways  (Kegg details for PGLS):
        Pentose phosphate pathway
    Metabolic pathways

    UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336
    Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate
    (oxidative stage): step 2/3


    PGLS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PGLS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/49 Interacting proteins for PGLS (O953362, 3 ENSP000002526034) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-66173 I2D: score=4 STRING: ENSP00000345494
    MDFIQ997502, 3, ENSP000002303214MINT-67509 I2D: score=5 STRING: ENSP00000230321
    POLR2EP193883, ENSP000002155874I2D: score=1 STRING: ENSP00000215587
    G6PDP114133, ENSP000003771924I2D: score=1 STRING: ENSP00000377192
    EWSR1Q018443, ENSP000003810314I2D: score=2 STRING: ENSP00000381031
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006098pentose-phosphate shunt TAS--
    GO:0009051pentose-phosphate shunt, oxidative branch IEA--
    GO:0044281small molecule metabolic process TAS--


    PGLS for ontologies           About GeneDecksing



    Drugs & Compounds
    for PGLS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGLS

    6 HMDB Compounds for PGLS    About this table
    CompoundSynonyms CAS #PubMed Ids
    6-Phosphogluconic acid6-Phospho-D-gluconate (see all 9)921-62-0--
    6-Phosphonoglucono-D-lactone6-(dihydrogen phosphate)-(8CI)-D-Gluconic acid delta-lactone (see all 13)2641-81-8--
    Gluconolactone1,5-Gluconolactone (see all 35)90-80-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phenolacide carbolique (see all 51)108-95-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about PGLS / 6PGL 

    Transcripts
    for PGLS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PGLS gene: 
    NM_012088.2  

    Unigene Cluster for PGLS:

    6-phosphogluconolactonase
    Hs.466165  [show with all ESTs]
    Unigene Representative Sequence: BQ065293
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252603(uc002ngw.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PGLS
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGLS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PGLS:
    hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmid: PGLS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PGLS (see all 4)
    OriGene shRNA RFP: PGLS
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGLS
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PGLS (NM_012088)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGLS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGLS 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PGLS
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PGLS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGLS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGLS

    Additional cDNA sequence: 

    AF091091.1 AJ243972.1 BC014006.2 

    14 DOTS entries:

    DT.449189  DT.100764019  DT.121431917  DT.95086204  DT.97772155  DT.121431773  DT.86854660  DT.91744838 
    DT.121432009  DT.97862348  DT.100815378  DT.100815379  DT.75145570  DT.92415224 

    24/241 AceView cDNA sequences (see all 241):

    BQ082658 AW009158 AA481484 BM694447 AA907740 AW957428 AI399976 AI370628 
    AW082760 AI143795 AI570406 AA235461 BG393149 AI554679 AI201491 BE675627 
    BQ230630 CD370440 AJ243972 AI695814 AW614464 CD675867 AI829785 BF593496 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PGLS    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:        -           -                                 
    SP2:        -                                             
    SP3:                    -                                 


    ECgene alternative splicing isoforms for PGLS

    Expression
    for PGLS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGLS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCTGGGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PGLS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGLS

    SOURCE GeneReport for Unigene cluster: Hs.466165
        SABiosciences Expression via Pathway-Focused PCR Array including PGLS: 
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PGLS

    Orthologs
    for PGLS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PGLS gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pgls1 , 5 6-phosphogluconolactonase1, 5 83.14(n)1
    89.11(a)1    		   8 (34.43 cM)5
    661711  NM_025396.31  NP_079672.11 
     715921765 
    chicken
    (Gallus gallus)    		 Aves BRD41 bromodomain containing 4 70.28(n)
    71.49(a)    		   430442  NM_001031588.1  NP_001026759.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 83(a)
    74(a)
    		 many → 1
    many → 1
    		 AAWZ02041598(2724-4642)
    GL343198.1(3801404-3811417)
    zebrafish
    (Danio rerio)    		 Actinopterygii pgls1 6-phosphogluconolactonase 64.15(n)
    70.75(a)    		   445494  NM_001004117.1  NP_001004117.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG173331 , 3 6-phosphogluconolactonase3
    CG173331    		 47(a)3
    53.6(n)1
    45.95(a)1    		   9F53
    320131  NM_132428.21  NP_572656.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y57G11C.36
    		 Putative 6-phosphogluconolactonase
    		 28(a)
    		 1 ↔ 1
    		 IV(14768123-14769252)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SOL3(YHR163W)4
    SOL31    		 6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p less4
    Sol3p1    		 42.49(n)1
    37.34(a)1    		   8(423724-424473)4
    8565681, 4  NP_012033.21, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons EMB20241 6-phosphogluconolactonase 48.31(n)
    42.03(a)    		   832511  NM_122348.2  NP_568445.1 
    rice
    (Oryza sativa)    		 Liliopsida Os09g05291001 hypothetical protein 50.21(n)
    41.77(a)    		   4347654  NM_001070276.1  NP_001063741.1 


    ENSEMBL Gene Tree for PGLS (if available)
    TreeFam Gene Tree for PGLS (if available) 

    Paralogs
    for PGLS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PGLS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/239 NCBI SNPs in PGLS are shown (see all 239)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1922102261,2
    		--17620452(+) TTTGCC/TCGTTG 1 -- us2k10--------
    rs1857441801,2
    		--17620455(+) GCTCGC/TTGCCC 1 -- us2k10--------
    rs1889066321,2
    		--17620575(+) ACCACA/GCCCAG 1 -- us2k10--------
    rs1932298741,2
    		--17620685(+) AAGTGC/TTGGAA 1 -- us2k10--------
    rs1498053001,2
    		--17620699(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs1457586241,2
    		--17620710(+) CACCAC/TGCCCA 1 -- us2k10--------
    rs72508641,2
    		C,F,A,H,--17620806(+) CAATCA/TTTTAT 1 -- us2k121Minor allele frequency- T:0.17NS EA NA WA CSA 2352
    rs1486758571,2
    		--17620852(+) GGTTAC/TTGTAC 1 -- us2k10--------
    rs1421462261,2
    		--17620888(+) TATGAC/GTCCTC 1 -- us2k10--------
    rs1478517401,2
    		--17620894(+) TCCTCC/GTATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PGLS (17622432 - 17632097 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PGLS: --

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    Disorders / Diseases
    for PGLS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PGLS for disorders           About GeneDecksing

    OMIM gene information: 604951    OMIM disorders: --

    5 diseases for PGLS:    About MalaCards
    von hippel-lindau disease    cranial nerve palsy    gastric lymphoma    tuberculosis
    mycobacterium tuberculosis

    3 diseases from the University of Copenhagen DISEASES database for PGLS:
    Paraganglioma     Gastric lymphoma     Von Hippel-Lindau disease

    Export disorders for PGLS gene to outside databases

    Publications
    for PGLS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGLS gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with PGLS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway. (PubMed id 10518023)1, 2, 3 Collard F....van Schaftingen E. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. (PubMed id 11457850)1 Miclet E....Duffieux F. (2001)

    External Searches for PGLS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing PGLS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25796 HGNC: 8903 AceView: PGLS Ensembl:ENSG00000130313 euGenes: HUgn25796
    ECgene: PGLS Kegg: 25796 H-InvDB: PGLS

    Other Databases showing PGLS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PGLS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGLS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PGLS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PGLS gene:
    Search GeneIP for patents involving PGLS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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