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Aliases for PGLS Gene

Aliases for PGLS Gene

  • 6-Phosphogluconolactonase 2 3 3 5
  • EC 3.1.1.31 4 61
  • 6PGL 3 4
  • Epididymis Secretory Protein Li 304 3
  • HEL-S-304 3

External Ids for PGLS Gene

Previous GeneCards Identifiers for PGLS Gene

  • GC19P018116
  • GC19P018014
  • GC19P017467
  • GC19P017484
  • GC19P017485
  • GC19P017486
  • GC19P017622
  • GC19P017189
  • GC19P017556
  • GC19P017702
  • GC19P017726
  • GC19P018301
  • GC19P018693

Summaries for PGLS Gene

GeneCards Summary for PGLS Gene

PGLS (6-Phosphogluconolactonase) is a Protein Coding gene. Diseases associated with PGLS include Lymphatic System Disease. Among its related pathways are Pentose Phosphate Pathway (Erythrocyte) and Pentose phosphate pathway. GO annotations related to this gene include monosaccharide binding and 6-phosphogluconolactonase activity.

UniProtKB/Swiss-Prot for PGLS Gene

  • Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGLS Gene

Genomics for PGLS Gene

Regulatory Elements for PGLS Gene

Enhancers for PGLS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G018372 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +869.5 869478 18.0 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ENSG00000268030 COLGALT1 UPF1 ENSG00000268938 MVB12A ENSG00000269191 KXD1 IFI30 GDF15 PGLS
GH19G018168 1.8 FANTOM5 ENCODE dbSUPER 11.9 +660.3 660300 7.4 CREB3L1 MLX AGO1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 NFYC ENSG00000268030 UPF1 ENSG00000268938 MVB12A ENSG00000269191 COLGALT1 MPV17L2 KXD1 LRRC25 IFI30
GH19G017552 1.5 FANTOM5 ENCODE 14.1 +43.2 43235 4.4 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 MVB12A ENSG00000267904 ENSG00000268087 PGLS FAM129C COLGALT1 ENSG00000269578 BST2 PLVAP RPL18A
GH19G018277 1.7 Ensembl ENCODE dbSUPER 11.9 +769.0 769005 6.4 MLX CREB3L1 AGO1 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF548 ZNF263 ENSG00000268030 UPF1 ENSG00000268938 KIAA1683 COLGALT1 MVB12A PDE4C LSM4 PGLS MPV17L2
GH19G017225 1.5 ENCODE dbSUPER 11.9 -284.8 -284810 2.8 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC OCEL1 ENSG00000269578 MVB12A ENSG00000268087 COLGALT1 PLVAP C19orf44 SMIM7 PGLS F2RL3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PGLS on UCSC Golden Path with GeneCards custom track

Promoters for PGLS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107921 77 2201 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 GLIS1

Genomic Location for PGLS Gene

Chromosome:
19
Start:
17,511,623 bp from pter
End:
17,521,288 bp from pter
Size:
9,666 bases
Orientation:
Plus strand

Genomic View for PGLS Gene

Genes around PGLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLS Gene

Proteins for PGLS Gene

  • Protein details for PGLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95336-6PGL_HUMAN
    Recommended name:
    6-phosphogluconolactonase
    Protein Accession:
    O95336

    Protein attributes for PGLS Gene

    Size:
    258 amino acids
    Molecular mass:
    27547 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72960.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PGLS Gene

Selected DME Specific Peptides for PGLS Gene

O95336:
  • FCDERLVPF
  • DGHTCSLFP
  • HPLLQEREKIVAPI
  • VATGEGKAA

Post-translational modifications for PGLS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGLS Gene

Domains & Families for PGLS Gene

Protein Domains for PGLS Gene

Suggested Antigen Peptide Sequences for PGLS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95336

UniProtKB/Swiss-Prot:

6PGL_HUMAN :
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Family:
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
genes like me logo Genes that share domains with PGLS: view

No data available for Gene Families for PGLS Gene

Function for PGLS Gene

Molecular function for PGLS Gene

GENATLAS Biochemistry:
6-phosphogluconolactonase,cytosolic,catalyzing the second step of the pentose-phosphate pathway
UniProtKB/Swiss-Prot CatalyticActivity:
6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate.
UniProtKB/Swiss-Prot Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Enzyme Numbers (IUBMB) for PGLS Gene

Gene Ontology (GO) - Molecular Function for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0016787 hydrolase activity IEA --
GO:0017057 6-phosphogluconolactonase activity IDA,IEA 10518023
genes like me logo Genes that share ontologies with PGLS: view
genes like me logo Genes that share phenotypes with PGLS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PGLS

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGLS Gene

Localization for PGLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGLS gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PGLS: view

Pathways & Interactions for PGLS Gene

genes like me logo Genes that share pathways with PGLS: view

UniProtKB/Swiss-Prot O95336-6PGL_HUMAN

  • Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.

Gene Ontology (GO) - Biological Process for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006098 pentose-phosphate shunt IEA,TAS --
GO:0009051 pentose-phosphate shunt, oxidative branch IBA --
genes like me logo Genes that share ontologies with PGLS: view

No data available for SIGNOR curated interactions for PGLS Gene

Drugs & Compounds for PGLS Gene

(5) Drugs for PGLS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 49
Water Approved Pharma 0
6-Phosphogluconic acid Experimental Pharma 0
Gluconolactone Experimental Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for PGLS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-Phosphonoglucono-D-lactone
  • 6-(Dihydrogen phosphate)-(8CI)-D-Gluconic acid delta-lactone
  • 6-(Dihydrogen phosphate)-(9CI)-D-Gluconic acid delta-lactone
  • 6-(Dihydrogen phosphate)-D-Gluconic acid delta-lactone
  • 6-Pgdl
  • 6-Phospho-D-glucono-1,5-lactone
2641-81-8
genes like me logo Genes that share compounds with PGLS: view

Transcripts for PGLS Gene

Unigene Clusters for PGLS Gene

6-phosphogluconolactonase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PGLS

Alternative Splicing Database (ASD) splice patterns (SP) for PGLS Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PGLS Gene

GeneLoc Exon Structure for
PGLS
ECgene alternative splicing isoforms for
PGLS

Expression for PGLS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGLS Gene

mRNA differential expression in normal tissues according to GTEx for PGLS Gene

This gene is overexpressed in Whole Blood (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PGLS Gene



Protein tissue co-expression partners for PGLS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PGLS Gene:

PGLS

SOURCE GeneReport for Unigene cluster for PGLS Gene:

Hs.466165

Evidence on tissue expression from TISSUES for PGLS Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Adrenal gland(2.9)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with PGLS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGLS Gene

Orthologs for PGLS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGLS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGLS 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia PGLS 34 35
  • 88.89 (n)
cow
(Bos Taurus)
Mammalia PGLS 34 35
  • 87.34 (n)
mouse
(Mus musculus)
Mammalia Pgls 34 16 35
  • 83.14 (n)
rat
(Rattus norvegicus)
Mammalia Pgls 34
  • 82.23 (n)
oppossum
(Monodelphis domestica)
Mammalia PGLS 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGLS 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRD4 34 35
  • 70.28 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 83 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pgls 34
  • 62.52 (n)
zebrafish
(Danio rerio)
Actinopterygii pgls 34 35
  • 64.15 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10079 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010866 34
  • 54.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17333 36 34 35
  • 53.75 (n)
worm
(Caenorhabditis elegans)
Secernentea Y57G11C.3 35
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER268W 34
  • 46.33 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08415g 34
  • 42.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOL3 35 37
  • 34 (a)
OneToMany
SOL4 35
  • 32 (a)
OneToMany
SOL2 35
  • 28 (a)
OneToMany
SOL1 35
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PGL1 34
  • 47.14 (n)
rice
(Oryza sativa)
Liliopsida Os07g0604000 34
  • 51.35 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00087 34
  • 56.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC16C4.10 34
  • 45.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1252 35
  • 45 (a)
OneToOne
Species where no ortholog for PGLS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGLS Gene

ENSEMBL:
Gene Tree for PGLS (if available)
TreeFam:
Gene Tree for PGLS (if available)

Paralogs for PGLS Gene

(1) SIMAP similar genes for PGLS Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PGLS: view

No data available for Paralogs for PGLS Gene

Variants for PGLS Gene

Sequence variations from dbSNP and Humsavar for PGLS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000048095 -- 17,511,895(+) GGACG(C/T)TGGGC upstream-variant-2KB, reference, synonymous-codon
rs1000251487 -- 17,510,935(+) GGGGT(C/T)CAAGA upstream-variant-2KB
rs1000584236 -- 17,515,836(+) GCTGG(C/T)CCCCG intron-variant
rs1000655653 -- 17,517,614(+) TGGGA(C/T)GGAAC intron-variant
rs1000716747 -- 17,521,138(+) GGCCC(C/T)TGCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PGLS Gene

Variant ID Type Subtype PubMed ID
nsv833768 CNV loss 17160897

Variation tolerance for PGLS Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGLS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGLS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGLS Gene

Disorders for PGLS Gene

MalaCards: The human disease database

(1) MalaCards diseases for PGLS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphatic system disease
  • adenopathy
- elite association - COSMIC cancer census association via MalaCards
Search PGLS in MalaCards View complete list of genes associated with diseases

Relevant External Links for PGLS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGLS
genes like me logo Genes that share disorders with PGLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGLS Gene

Publications for PGLS Gene

  1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway. (PMID: 10518023) Collard F. … van Schaftingen E. (FEBS Lett. 1999) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for PGLS Gene

Sources for PGLS Gene

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