PGLS Gene
protein-coding GIFtS: 57
GCID: GC19P017622
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6-phosphogluconolactonase
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Aliases
for PGLS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 6-Phosphogluconolactonase1 | | 6PGL1 2 3 | | EC 3.1.1.313 8 |
Export aliases for PGLS gene to outside databasesPrevious GC identifers: GC19P018116 GC19P018014 GC19P017467 GC19P017484 GC19P017485 GC19P017486 GC19P017189 |
Summaries
for PGLS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336Function: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
|
Genomic Views
for PGLS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PGLS gene promoter:
Lmo2 STAT5A CUTL1 E47 Arnt HEN1 AREB6 PPAR-gamma1 PPAR-gamma2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for PGLS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGLS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.2PGLS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P017622: view genomic region
(about GC identifiers)
Start:
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17,622,432 bp from pter |
End:
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17,632,097 bp from pter |
Size:
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9,666 bases |
Orientation:
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plus strand |
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Proteins
for PGLS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336 (See
protein sequence)Recommended Name: 6-phosphogluconolactonase Size: 258 amino acids; 27547 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAC72960.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for PGLS: NX_O95336
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95336
4 DME Specific Peptides for PGLS (O95336)
PGLS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036220.1
ENSEMBL proteins: ENSP00000252603 Reactome Protein details: O95336
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PGLS for ontologies About GeneDecksing
PGLS Antibody Products:
Assay Products for PGLS: |
Protein
Domains /
Families
for PGLS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PGLS for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95336ProtoNet protein and cluster: O95336 UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily |
Function
for PGLS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336Function: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconateCatalytic activity: 6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate Genatlas biochemistry entry for PGLS:6-phosphogluconolactonase,cytosolic,catalyzing the second step of the pentose-phosphate pathway
Enzyme Number (IUBMB): EC 3.1.1.311 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PGLS (NM_012088) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PGLS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGLS |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
PGLS for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PGLS:
|
Pathways & Interactions
for PGLS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pentose phosphate pathway (hexose monophosphate shunt) | | | 2 | Metabolism | | | 3 | Pentose Phosphate Pathway (Erythrocyte) | | | 4 | Pentose phosphate pathway | | | 5 | MPS IIIC - Sanfilippo syndrome C | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for PGLS
3 
Reactome Pathways for PGLS
1  PharmGKB Pathway for PGLS
2 
Kegg Pathways (Kegg details for PGLS):
UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate(oxidative stage): step 2/3
PGLS for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PGLS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/49 Interacting proteins for PGLS (O953362, 3 ENSP000002526034) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0006098 | pentose-phosphate shunt |
TAS | -- | | GO:0009051 | pentose-phosphate shunt, oxidative branch |
IEA | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
PGLS for ontologies About GeneDecksing
|
Drugs & Compounds
for PGLS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PGLS
6 HMDB Compounds for PGLS About this table
Search CenterWatch for drugs/clinical trials and news about PGLS / 6PGL
|
Transcripts
for PGLS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PGLS gene: NM_012088.2 Unigene Cluster for PGLS: 6-phosphogluconolactonase Hs.466165 [show with all ESTs]Unigene Representative Sequence: BQ0652931 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000252603(uc002ngw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PGLS (NM_012088) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PGLS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGLS |
Additional cDNA sequence: AF091091.1 AJ243972.1 BC014006.2 14 DOTS entries: DT.449189 DT.100764019 DT.121431917 DT.95086204 DT.97772155 DT.121431773 DT.86854660 DT.91744838 DT.121432009 DT.97862348 DT.100815378 DT.100815379 DT.75145570 DT.92415224 24/241 AceView cDNA sequences (see all 241): BQ082658 AW009158 AA481484 BM694447 AA907740 AW957428 AI399976 AI370628 AW082760 AI143795 AI570406 AA235461 BG393149 AI554679 AI201491 BE675627 BQ230630 CD370440 AJ243972 AI695814 AW614464 CD675867 AI829785 BF593496
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for PGLS About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b |
|---|
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| SP1: | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for PGLS
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Expression
for PGLS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PGLS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCTGGGCC
About this image
See PGLS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PGLS
SOURCE GeneReport for Unigene cluster: Hs.466165
SABiosciences Expression via Pathway-Focused PCR Array including PGLS:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PGLS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PGLS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGLS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGLS |
Orthologs
for PGLS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PGLS gene from 9/32 species (see all 32) About this table
ENSEMBL Gene Tree for PGLS (if available)
TreeFam Gene Tree for PGLS (if available) |
Paralogs
for PGLS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PGLS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PGLS (17622432 - 17632097 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PGLS: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGLS |
|
Disorders
/ Diseases
for PGLS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PGLS for disorders About GeneDecksing
OMIM gene information: 604951
OMIM disorders: --
5  diseases for PGLS: About MalaCardsvon hippel-lindau disease cranial nerve palsy gastric lymphoma tuberculosis
mycobacterium tuberculosis
3 diseases from the University of Copenhagen DISEASES database for PGLS:Paraganglioma Gastric lymphoma Von Hippel-Lindau disease Export disorders for PGLS gene to outside databases
|
Publications
for PGLS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PGLS gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with PGLS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway. (PubMed id 10518023)1, 2, 3 Collard F....van Schaftingen E. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. (PubMed id 11457850)1 Miclet E....Duffieux F. (2001)
|
External Searches for PGLS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PGLS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PGLS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PGLS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PGLS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PGLS gene:
Search GeneIP for patents involving PGLS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PGLS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PGLS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PGLS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PGLS | | | OriGene Protein Over-expression Lysate for PGLS | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for PGLS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGLS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PGLS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PGLS | | OriGene Custom Protein Services for PGLS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PGLS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGLS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGLS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGLS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGLS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGLS |
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 |  |  |  | |
| | | | Search Tocris compounds for PGLS |
| |  |  |  |  | | | | | | Recombinant Protein for PGLS |
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 | | | PGLS Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for PGLS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGLS |
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