Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PGLS Gene

Aliases for PGLS Gene

  • 6-Phosphogluconolactonase 5 2 3
  • EC 3.1.1.31 4 63
  • 6PGL 3 4
  • Epididymis Secretory Protein Li 304 3
  • HEL-S-304 3

External Ids for PGLS Gene

Previous GeneCards Identifiers for PGLS Gene

  • GC19P018116
  • GC19P018014
  • GC19P017467
  • GC19P017484
  • GC19P017485
  • GC19P017486
  • GC19P017622
  • GC19P017189
  • GC19P017556
  • GC19P017702

Summaries for PGLS Gene

GeneCards Summary for PGLS Gene

PGLS (6-Phosphogluconolactonase) is a Protein Coding gene. Diseases associated with PGLS include Lymphatic System Disease. Among its related pathways are Glycosaminoglycan metabolism and Pentose phosphate pathway. GO annotations related to this gene include monosaccharide binding and 6-phosphogluconolactonase activity.

UniProtKB/Swiss-Prot for PGLS Gene

  • Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGLS Gene

Genomics for PGLS Gene

Regulatory Elements for PGLS Gene

Enhancers for PGLS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PGLS on UCSC Golden Path with GeneCards custom track

Promoters for PGLS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PGLS on UCSC Golden Path with GeneCards custom track

Genomic Location for PGLS Gene

Chromosome:
19
Start:
17,511,623 bp from pter
End:
17,521,288 bp from pter
Size:
9,666 bases
Orientation:
Plus strand

Genomic View for PGLS Gene

Genes around PGLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLS Gene

Proteins for PGLS Gene

  • Protein details for PGLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95336-6PGL_HUMAN
    Recommended name:
    6-phosphogluconolactonase
    Protein Accession:
    O95336

    Protein attributes for PGLS Gene

    Size:
    258 amino acids
    Molecular mass:
    27547 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72960.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PGLS Gene

Proteomics data for PGLS Gene at MOPED

Selected DME Specific Peptides for PGLS Gene

Post-translational modifications for PGLS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGLS Gene

Domains & Families for PGLS Gene

Protein Domains for PGLS Gene

Suggested Antigen Peptide Sequences for PGLS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95336

UniProtKB/Swiss-Prot:

6PGL_HUMAN :
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Family:
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
genes like me logo Genes that share domains with PGLS: view

No data available for Gene Families for PGLS Gene

Function for PGLS Gene

Molecular function for PGLS Gene

GENATLAS Biochemistry:
6-phosphogluconolactonase,cytosolic,catalyzing the second step of the pentose-phosphate pathway
UniProtKB/Swiss-Prot CatalyticActivity:
6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate.
UniProtKB/Swiss-Prot Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Enzyme Numbers (IUBMB) for PGLS Gene

Gene Ontology (GO) - Molecular Function for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0017057 6-phosphogluconolactonase activity IEA,IDA 10518023
genes like me logo Genes that share ontologies with PGLS: view
genes like me logo Genes that share phenotypes with PGLS: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGLS Gene

Localization for PGLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGLS Gene COMPARTMENTS Subcellular localization image for PGLS gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PGLS Gene

Pathways & Interactions for PGLS Gene

genes like me logo Genes that share pathways with PGLS: view

UniProtKB/Swiss-Prot O95336-6PGL_HUMAN

  • Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.

Gene Ontology (GO) - Biological Process for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006098 pentose-phosphate shunt IEA,TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PGLS: view

No data available for SIGNOR curated interactions for PGLS Gene

Drugs & Compounds for PGLS Gene

(4) Drugs for PGLS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 44
6-Phosphogluconic acid Experimental Pharma 0
Gluconolactone Experimental Pharma 0
Magnesium Nutra 0

(2) Additional Compounds for PGLS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
6-Phosphonoglucono-D-lactone
  • 6-(Dihydrogen phosphate)-(8CI)-D-Gluconic acid delta-lactone
  • 6-(Dihydrogen phosphate)-(9CI)-D-Gluconic acid delta-lactone
  • 6-(Dihydrogen phosphate)-D-Gluconic acid delta-lactone
  • 6-Pgdl
  • 6-Phospho-D-glucono-1,5-lactone
2641-81-8
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PGLS: view

Transcripts for PGLS Gene

Unigene Clusters for PGLS Gene

6-phosphogluconolactonase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGLS Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PGLS Gene

GeneLoc Exon Structure for
PGLS
ECgene alternative splicing isoforms for
PGLS

Expression for PGLS Gene

mRNA expression in normal human tissues for PGLS Gene

mRNA differential expression in normal tissues according to GTEx for PGLS Gene

This gene is overexpressed in Whole Blood (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGLS Gene



SOURCE GeneReport for Unigene cluster for PGLS Gene Hs.466165

genes like me logo Genes that share expression patterns with PGLS: view

Protein tissue co-expression partners for PGLS Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PGLS Gene

Orthologs for PGLS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGLS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGLS 35
  • 87.34 (n)
  • 92.64 (a)
PGLS 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGLS 35
  • 88.89 (n)
  • 96.51 (a)
PGLS 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgls 35
  • 83.14 (n)
  • 89.11 (a)
Pgls 16
Pgls 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGLS 35
  • 99.22 (n)
  • 99.61 (a)
PGLS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgls 35
  • 82.23 (n)
  • 89.11 (a)
oppossum
(Monodelphis domestica)
Mammalia PGLS 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGLS 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRD4 35
  • 70.28 (n)
  • 71.49 (a)
BRD4 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pgls 35
  • 62.52 (n)
  • 64.73 (a)
zebrafish
(Danio rerio)
Actinopterygii pgls 35
  • 64.15 (n)
  • 70.75 (a)
pgls 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10079 35
fruit fly
(Drosophila melanogaster)
Insecta CG17333 37
  • 47 (a)
CG17333 35
  • 53.75 (n)
  • 45.95 (a)
CG17333 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010866 35
  • 54.05 (n)
  • 49.51 (a)
worm
(Caenorhabditis elegans)
Secernentea Y57G11C.3 36
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER268W 35
  • 46.33 (n)
  • 42.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08415g 35
  • 42.83 (n)
  • 38.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOL1 36
  • 26 (a)
OneToMany
SOL2 36
  • 28 (a)
OneToMany
SOL3 36
  • 34 (a)
OneToMany
SOL4 36
  • 32 (a)
OneToMany
SOL3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PGL1 35
  • 47.14 (n)
  • 38.49 (a)
rice
(Oryza sativa)
Liliopsida Os07g0604000 35
  • 51.35 (n)
  • 43.78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00087 35
  • 56.14 (n)
  • 50.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC16C4.10 35
  • 45.36 (n)
  • 43.91 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1252 36
  • 45 (a)
OneToOne
Species with no ortholog for PGLS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGLS Gene

ENSEMBL:
Gene Tree for PGLS (if available)
TreeFam:
Gene Tree for PGLS (if available)

Paralogs for PGLS Gene

(1) SIMAP similar genes for PGLS Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PGLS: view

No data available for Paralogs for PGLS Gene

Variants for PGLS Gene

Sequence variations from dbSNP and Humsavar for PGLS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7508245 -- 17,514,462(+) ttcct(C/T)ccttc intron-variant
rs12981114 -- 17,516,789(+) TCACC(A/G)TGTTA intron-variant
rs8102140 -- 17,512,530(+) CCTGA(A/G)TCTCA intron-variant, utr-variant-5-prime
rs8104468 -- 17,517,928(+) CATTA(C/T)TGTGC intron-variant
rs8104734 -- 17,513,396(+) gtggt(A/G)cgcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGLS Gene

Variant ID Type Subtype PubMed ID
nsv911182 CNV Loss 21882294
nsv833768 CNV Loss 17160897
dgv3761n71 CNV Loss 21882294
nsv911205 CNV Loss 21882294
dgv3762n71 CNV Loss 21882294

Variation tolerance for PGLS Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PGLS Gene

Disorders for PGLS Gene

MalaCards: The human disease database

(1) MalaCards diseases for PGLS Gene - From: DISEASES

Disorder Aliases PubMed IDs
lymphatic system disease
  • adenopathy
- elite association - COSMIC cancer census association via MalaCards
Search PGLS in MalaCards View complete list of genes associated with diseases

Relevant External Links for PGLS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGLS
genes like me logo Genes that share disorders with PGLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGLS Gene

Publications for PGLS Gene

  1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway. (PMID: 10518023) Collard F. … van Schaftingen E. (FEBS Lett. 1999) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for PGLS Gene

Sources for PGLS Gene

Content