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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGLS Gene

protein-coding   GIFtS: 61
GCID: GC19P017622

6-Phosphogluconolactonase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
6-phosphogluconolactonase1 2
6PGL2 3
EC 3.1.1.313 8

External Ids:    HGNC: 89031   Entrez Gene: 257962   Ensembl: ENSG000001303137   OMIM: 6049515   UniProtKB: O953363   

Export aliases for PGLS gene to outside databases

Previous GC identifers: GC19P018116 GC19P018014 GC19P017467 GC19P017484 GC19P017485 GC19P017486 GC19P017189


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PGLS Gene: 
PGLS (6-phosphogluconolactonase) is a protein-coding gene. Diseases associated with PGLS include cranial nerve palsy, and gastric lymphoma, and among its related super-pathways are Pentose phosphate pathway (hexose monophosphate shunt) and pentose phosphate pathway (oxidative branch). GO annotations related to this gene include 6-phosphogluconolactonase activity and monosaccharide binding.

UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336
Function: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGLS gene promoter:
         Lmo2   STAT5A   CUTL1   E47   Arnt   HEN1   AREB6   PPAR-gamma1   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPGLS promoter sequence
   Search SABiosciences Chromatin IP Primers for PGLS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2

PGLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGLS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017622:  view genomic region     (about GC identifiers)

Start:
17,622,432 bp from pter      End:
17,632,097 bp from pter
Size:
9,666 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336 (See protein sequence)
Recommended Name: 6-phosphogluconolactonase  
Size: 258 amino acids; 27547 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAC72960.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for PGLS: NX_O95336

Explore proteomics data for PGLS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95336

  • 4 DME Specific Peptides for PGLS (O95336)
     VATGEGKAA  DGHTCSLFP  FCDERLVPF  HPLLQEREKIVAPI 

    PGLS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PGLS Protein Expression
    REFSEQ proteins: NP_036220.1  
    ENSEMBL proteins: 
     ENSP00000252603   ENSP00000471446   ENSP00000472345   ENSP00000471951  
    Reactome Protein details: O95336
    Human Recombinant Protein Products for PGLS: 
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    OriGene Protein Over-expression Lysate for PGLS
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    GenScript Custom Purified and Recombinant Proteins Services for PGLS
    Novus Biologicals PGLS Proteins
    Novus Biologicals PGLS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PGLS
    Cloud-Clone Corp. Proteins for PGLS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    PGLS for ontologies           About GeneDecksing



    PGLS Antibody Products: 
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    Cloud-Clone Corp. ELISAs for PGLS 
    Cloud-Clone Corp. CLIAs for PGLS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006148 Glc/Gal-6P_isomerase
     IPR005900 6-phosphogluconolactonase_DevB

    Graphical View of Domain Structure for InterPro Entry O95336

    ProtoNet protein and cluster: O95336

    UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336
    Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase
    subfamily


    PGLS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 6PGL_HUMAN, O95336
    Function: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
    Catalytic activity: 6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate

         Genatlas biochemistry entry for PGLS:
    6-phosphogluconolactonase,cytosolic,catalyzing the second step of the pentose-phosphate pathway

         Enzyme Number (IUBMB): EC 3.1.1.311 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00170576-phosphogluconolactonase activity IDA10518023
    GO:0048029monosaccharide binding IEA--
         
    PGLS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PGLS:
     Cell cycle / mitosis defect  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PGLS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PGLS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PGLS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PGLS 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGLS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PGLS:
    hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidPGLS 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGLS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PGLS About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Pentose phosphate pathway (hexose monophosphate shunt)
    Pentose phosphate pathway (hexose monophosphate shunt)0.88
    pentose phosphate pathway0.67
    Pentose Phosphate Pathway0.88
    2Pentose Phosphate Pathway (Erythrocyte)
    Pentose Phosphate Pathway (Erythrocyte)0.60
    pentose phosphate pathway (oxidative branch)0.60
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    5Carbon metabolism
    Carbon metabolism0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for PGLS
        pentose phosphate pathway
    pentose phosphate pathway (oxidative branch)
    Pentose Phosphate Pathway

    3        Reactome Pathways for PGLS
        Metabolism of carbohydrates
    Pentose phosphate pathway (hexose monophosphate shunt)
    Metabolism

    1 PharmGKB Pathway for PGLS
        Pentose Phosphate Pathway (Erythrocyte)

    3         Kegg Pathways  (Kegg details for PGLS):
        Pentose phosphate pathway
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: 6PGL_HUMAN, O95336
    Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate
    (oxidative stage): step 2/3


    PGLS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PGLS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/49 Interacting proteins for PGLS (O953362, 3 ENSP000002526034) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-66173 I2D: score=4 STRING: ENSP00000345494
    MDFIQ997502, 3, ENSP000002303214MINT-67509 I2D: score=5 STRING: ENSP00000230321
    POLR2EP193883, ENSP000002155874I2D: score=1 STRING: ENSP00000215587
    G6PDP114133, ENSP000003771924I2D: score=1 STRING: ENSP00000377192
    EWSR1Q018443, ENSP000003810314I2D: score=2 STRING: ENSP00000381031
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006098pentose-phosphate shunt TAS--
    GO:0009051pentose-phosphate shunt, oxidative branch IEA--
    GO:0044281small molecule metabolic process TAS--

    PGLS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGLS (6PGL)

    6 HMDB Compounds for PGLS    About this table
    CompoundSynonyms CAS #PubMed Ids
    6-Phosphogluconic acid6-Phospho-D-gluconate (see all 9)921-62-0--
    6-Phosphonoglucono-D-lactone6-(dihydrogen phosphate)-(8CI)-D-Gluconic acid delta-lactone (see all 13)2641-81-8--
    Gluconolactone1,5-Gluconolactone (see all 35)90-80-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phenolacide carbolique (see all 51)108-95-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PGLS / 6PGL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PGLS gene: 
    NM_012088.2  

    Unigene Cluster for PGLS:

    6-phosphogluconolactonase
    Hs.466165  [show with all ESTs]
    Unigene Representative Sequence: BQ065293
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252603(uc002ngw.3) ENST00000594761 ENST00000596799 ENST00000600923
    ENST00000595782 ENST00000598811
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PGLS:
    hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidPGLS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGLS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGLS
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGLS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGLS

    Additional mRNA sequence: 

    AF091091.1 AJ243972.1 BC014006.2 

    14 DOTS entries:

    DT.449189  DT.100764019  DT.121431917  DT.95086204  DT.97772155  DT.121431773  DT.86854660  DT.91744838 
    DT.121432009  DT.97862348  DT.100815378  DT.100815379  DT.75145570  DT.92415224 

    24/241 AceView cDNA sequences (see all 241):

    AA454496 BQ440959 AW009158 BM930948 AW375222 NM_012088 BC017706 AA235461 
    AI695814 BQ015081 AA830164 AI695807 AI399976 BU538859 AI383334 AA434058 
    AJ243972 AA397820 AI291093 AI201491 M91222 AI566946 BQ082658 AW957428 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PGLS    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:        -           -                                 
    SP2:        -                                             
    SP3:                    -                                 


    ECgene alternative splicing isoforms for PGLS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGLS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTGGGCC
    PGLS Expression
    About this image


    See PGLS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGLS

    SOURCE GeneReport for Unigene cluster: Hs.466165
        SABiosciences Expression via Pathway-Focused PCR Array including PGLS: 
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGLS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PGLS gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pgls1 , 5 6-phosphogluconolactonase1, 5 83.14(n)1
    89.11(a)1
      8 (34.43 cM)5
    661711  NM_025396.31  NP_079672.11 
     715921765 
    chicken
    (Gallus gallus)
    Aves BRD41 bromodomain containing 4 70.28(n)
    71.49(a)
      430442  NM_001031588.1  NP_001026759.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    83(a)
    73(a)
    many → 1
    many → 1
    AAWZ02041598(2724-4642)
    GL343198.1(3801404-3811417)
    zebrafish
    (Danio rerio)
    Actinopterygii pgls1 6-phosphogluconolactonase 64.15(n)
    70.75(a)
      445494  NM_001004117.1  NP_001004117.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG173331 , 3 6-phosphogluconolactonase3
    CG173331
    47(a)3
    53.6(n)1
    45.95(a)1
      9F53
    320131  NM_132428.21  NP_572656.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y57G11C.36
    Putative 6-phosphogluconolactonase
    29(a)
    1 ↔ 1
    IV(14768155-14769284)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SOL3(YHR163W)4
    SOL31
    6-phosphogluconolactonase, catalyzes the second step more4
    Sol3p1
    42.49(n)1
    37.34(a)1
      8(423724-424473)4
    8565681, 4  NP_012033.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB20241 6-phosphogluconolactonase 48.31(n)
    42.03(a)
      832511  NM_122348.2  NP_568445.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05291001 hypothetical protein 50.21(n)
    41.77(a)
      4347654  NM_001070276.1  NP_001063741.1 


    ENSEMBL Gene Tree for PGLS (if available)
    TreeFam Gene Tree for PGLS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGLS gene
    1 SIMAP similar gene for PGLS using alignment to 4 protein entries:     6PGL_HUMAN (see all proteins):
    H6PD

    PGLS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/297 SNPs in PGLS are shown (see all 297)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922102261,2
    --17620452(+) TTTGCC/TCGTTG 1 -- us2k10--------
    rs1857441801,2
    --17620455(+) GCTCGC/TTGCCC 1 -- us2k10--------
    rs1889066321,2
    --17620575(+) ACCACA/GCCCAG 1 -- us2k10--------
    rs1932298741,2
    --17620685(+) AAGTGC/TTGGAA 1 -- us2k10--------
    rs1498053001,2
    --17620699(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs1457586241,2
    C--17620710(+) CACCAC/TGCCCA 1 -- us2k10--------
    rs72508641,2
    C,F,A,H--17620806(+) caatcA/Ttttat 1 -- us2k121Minor allele frequency- T:0.17NS EA NA WA CSA 2352
    rs1486758571,2
    --17620852(+) GGTTAC/TTGTAC 1 -- us2k10--------
    rs1421462261,2
    --17620888(+) TATGAC/GTCCTC 1 -- us2k10--------
    rs1478517401,2
    C--17620894(+) TCCTCC/GTATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PGLS (17622432 - 17632097 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PGLS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911182CNV Loss21882294
    dgv3761n71CNV Loss21882294
    dgv3762n71CNV Loss21882294
    nsv911205CNV Loss21882294
    nsv833768CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604951    OMIM disorders: --

    5 diseases for PGLS:    About MalaCards
    cranial nerve palsy    gastric lymphoma    von hippel-lindau disease    paraganglioma
    tuberculosis

    3 diseases from the University of Copenhagen DISEASES database for PGLS:
    Paraganglioma     Gastric lymphoma     Von Hippel-Lindau disease

    PGLS for disorders           About GeneDecksing


    Export disorders for PGLS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGLS gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with PGLS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway. (PubMed id 10518023)1, 2, 3 Collard F....van Schaftingen E. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25796 HGNC: 8903 AceView: PGLS Ensembl:ENSG00000130313 euGenes: HUgn25796
    ECgene: PGLS Kegg: 25796 H-InvDB: PGLS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGLS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PGLS gene:
    Search GeneIP for patents involving PGLS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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