Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PGLS Gene

Aliases for PGLS Gene

  • 6-Phosphogluconolactonase 2 3
  • EC 4 63
  • 6PGL 3 4

External Ids for PGLS Gene

Previous GeneCards Identifiers for PGLS Gene

  • GC19P018116
  • GC19P018014
  • GC19P017467
  • GC19P017484
  • GC19P017485
  • GC19P017486
  • GC19P017622
  • GC19P017189

Summaries for PGLS Gene

GeneCards Summary for PGLS Gene

PGLS (6-Phosphogluconolactonase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include monosaccharide binding and 6-phosphogluconolactonase activity.

UniProtKB/Swiss-Prot for PGLS Gene

  • Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGLS Gene

Genomics for PGLS Gene

Regulatory Elements for PGLS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PGLS Gene

17,511,469 bp from pter
17,521,288 bp from pter
9,820 bases
Plus strand

Genomic View for PGLS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGLS Gene

Proteins for PGLS Gene

  • Protein details for PGLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PGLS Gene

    258 amino acids
    Molecular mass:
    27547 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC72960.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PGLS Gene

Proteomics data for PGLS Gene at MOPED

Selected DME Specific Peptides for PGLS Gene

Post-translational modifications for PGLS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGLS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for PGLS Gene

Protein Domains for PGLS Gene

Suggested Antigen Peptide Sequences for PGLS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95336
  • Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
genes like me logo Genes that share domains with PGLS: view

No data available for Gene Families for PGLS Gene

Function for PGLS Gene

Molecular function for PGLS Gene

GENATLAS Biochemistry:
6-phosphogluconolactonase,cytosolic,catalyzing the second step of the pentose-phosphate pathway
UniProtKB/Swiss-Prot CatalyticActivity:
6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate
UniProtKB/Swiss-Prot Function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate

Enzyme Numbers (IUBMB) for PGLS Gene

Gene Ontology (GO) - Molecular Function for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017057 6-phosphogluconolactonase activity IDA 10518023
GO:0048029 monosaccharide binding IEA --
genes like me logo Genes that share ontologies with PGLS: view

Phenotypes for PGLS Gene

genes like me logo Genes that share phenotypes with PGLS: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGLS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PGLS Gene

Localization for PGLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGLS Gene


Subcellular locations from

Jensen Localization Image for PGLS Gene COMPARTMENTS Subcellular localization image for PGLS gene
Compartment Confidence
cytosol 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PGLS: view

Pathways for PGLS Gene

genes like me logo Genes that share pathways with PGLS: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O95336-6PGL_HUMAN

  • Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3

Gene Ontology (GO) - Biological Process for PGLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006098 pentose-phosphate shunt TAS --
GO:0009051 pentose-phosphate shunt, oxidative branch IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PGLS: view

Compounds for PGLS Gene

(6) HMDB Compounds for PGLS Gene

Compound Synonyms Cas Number PubMed IDs
6-Phosphogluconic acid
  • 6-Phospho-D-gluconate
  • 6-(dihydrogen phosphate)-(8CI)-D-Gluconic acid delta-lactone
  • 1,5-Gluconolactone
  • Magnesium
  • acide carbolique
genes like me logo Genes that share compounds with PGLS: view

Transcripts for PGLS Gene

mRNA/cDNA for PGLS Gene

Unigene Clusters for PGLS Gene

Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGLS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGLS Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3: -

Relevant External Links for PGLS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGLS Gene

mRNA expression in normal human tissues for PGLS Gene

mRNA differential expression in normal tissues according to GTEx for PGLS Gene

This gene is overexpressed in Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGLS Gene

SOURCE GeneReport for Unigene cluster for PGLS Gene Hs.466165

genes like me logo Genes that share expressions with PGLS: view

Expression partners for PGLS Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PGLS Gene

Orthologs for PGLS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGLS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PGLS 35
  • 87.34 (n)
  • 92.64 (a)
  • 93 (a)
(Canis familiaris)
Mammalia PGLS 35
  • 88.89 (n)
  • 96.51 (a)
  • 97 (a)
(Mus musculus)
Mammalia Pgls 35
  • 83.14 (n)
  • 89.11 (a)
Pgls 16
Pgls 36
  • 89 (a)
(Pan troglodytes)
Mammalia PGLS 35
  • 99.22 (n)
  • 99.61 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Pgls 35
  • 82.23 (n)
  • 89.11 (a)
(Monodelphis domestica)
Mammalia PGLS 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia PGLS 36
  • 81 (a)
(Gallus gallus)
Aves BRD4 35
  • 70.28 (n)
  • 71.49 (a)
BRD4 36
  • 86 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
-- 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgls 35
  • 62.52 (n)
  • 64.73 (a)
(Danio rerio)
Actinopterygii pgls 35
  • 64.15 (n)
  • 70.75 (a)
pgls 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10079 35
fruit fly
(Drosophila melanogaster)
Insecta CG17333 37
  • 47 (a)
CG17333 35
  • 53.75 (n)
  • 45.95 (a)
CG17333 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010866 35
  • 54.05 (n)
  • 49.51 (a)
(Caenorhabditis elegans)
Secernentea Y57G11C.3 36
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER268W 35
  • 46.33 (n)
  • 42.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08415g 35
  • 42.83 (n)
  • 38.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOL1 36
  • 26 (a)
SOL2 36
  • 28 (a)
SOL3 36
  • 34 (a)
SOL4 36
  • 32 (a)
SOL3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PGL1 35
  • 47.14 (n)
  • 38.49 (a)
(Oryza sativa)
Liliopsida Os07g0604000 35
  • 51.35 (n)
  • 43.78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00087 35
  • 56.14 (n)
  • 50.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC16C4.10 35
  • 45.36 (n)
  • 43.91 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1252 36
  • 45 (a)
Species with no ortholog for PGLS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGLS Gene

Gene Tree for PGLS (if available)
Gene Tree for PGLS (if available)

Paralogs for PGLS Gene

Selected SIMAP similar genes for PGLS Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PGLS: view

No data available for Paralogs for PGLS Gene

Variants for PGLS Gene

Sequence variations from dbSNP and Humsavar for PGLS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs6743 -- 17,517,778(+) CTCAC(A/G)CTACC reference, synonymous-codon
rs753888 -- 17,519,862(+) CAACC(A/G)CAGTA intron-variant
rs879142 -- 17,511,582(-) TCGAG(C/T)ACTTT upstream-variant-2KB, reference, synonymous-codon
rs891182 -- 17,510,949(+) GCCTA(A/G)ACCAT upstream-variant-2KB
rs1001046 -- 17,515,548(-) CCAGG(C/T)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGLS Gene

Variant ID Type Subtype PubMed ID
nsv911182 CNV Loss 21882294
nsv833768 CNV Loss 17160897
dgv3761n71 CNV Loss 21882294
nsv911205 CNV Loss 21882294
dgv3762n71 CNV Loss 21882294

Relevant External Links for PGLS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGLS Gene

Disorders for PGLS Gene

(3) University of Copenhagen DISEASES for PGLS Gene

genes like me logo Genes that share disorders with PGLS: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for PGLS Gene

Publications for PGLS Gene

  1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway. (PMID: 10518023) Collard F. … van Schaftingen E. (FEBS Lett. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3

Products for PGLS Gene

Sources for PGLS Gene

Back to Top