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Aliases for PGK2 Gene

Aliases for PGK2 Gene

  • Phosphoglycerate Kinase 2 2 3 5
  • Phosphoglycerate Kinase, Testis Specific 3 4
  • EC 4 63
  • PGKB 3 4
  • Phosphoglycerate Kinase Autosomal Pseudogene 3
  • Epididymis Secretory Protein Li 272 3
  • Testicular Tissue Protein Li 139 3
  • DJ417L20.2 3
  • HEL-S-272 3
  • PGKPS 3

External Ids for PGK2 Gene

Previous GeneCards Identifiers for PGK2 Gene

  • GC06M049755
  • GC06M049800
  • GC06M049861
  • GC06M049753
  • GC06M049483

Summaries for PGK2 Gene

Entrez Gene Summary for PGK2 Gene

  • This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]

GeneCards Summary for PGK2 Gene

PGK2 (Phosphoglycerate Kinase 2) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Carbon metabolism. GO annotations related to this gene include phosphoglycerate kinase activity. An important paralog of this gene is PGK1.

UniProtKB/Swiss-Prot for PGK2 Gene

  • Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGK2 Gene

Genomics for PGK2 Gene

Regulatory Elements for PGK2 Gene

Enhancers for PGK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PGK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PGK2 Gene

49,785,651 bp from pter
49,787,340 bp from pter
1,690 bases
Minus strand

Genomic View for PGK2 Gene

Genes around PGK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGK2 Gene

Proteins for PGK2 Gene

  • Protein details for PGK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphoglycerate kinase 2
    Protein Accession:
    Secondary Accessions:
    • B2R6Y8
    • Q9H107

    Protein attributes for PGK2 Gene

    417 amino acids
    Molecular mass:
    44796 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for PGK2 Gene

Proteomics data for PGK2 Gene at MOPED

Post-translational modifications for PGK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PGK2 Gene

Suggested Antigen Peptide Sequences for PGK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phosphoglycerate kinase family.
  • Belongs to the phosphoglycerate kinase family.
genes like me logo Genes that share domains with PGK2: view

No data available for Gene Families for PGK2 Gene

Function for PGK2 Gene

Molecular function for PGK2 Gene

GENATLAS Biochemistry:
phosphoglycerate kinase 2,specifically expressed in spermatogenic cell,highly homologous to PGK1,glycolysis,energy pathway,key enzyme for ATP generation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
UniProtKB/Swiss-Prot Function:
Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity).

Enzyme Numbers (IUBMB) for PGK2 Gene

genes like me logo Genes that share phenotypes with PGK2: view

Animal Models for PGK2 Gene

MGI Knock Outs for PGK2:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PGK2 Gene

Localization for PGK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGK2 Gene


Subcellular locations from

Jensen Localization Image for PGK2 Gene COMPARTMENTS Subcellular localization image for PGK2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PGK2: view

Pathways & Interactions for PGK2 Gene

genes like me logo Genes that share pathways with PGK2: view

Pathways by source for PGK2 Gene

UniProtKB/Swiss-Prot P07205-PGK2_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Gene Ontology (GO) - Biological Process for PGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with PGK2: view

No data available for SIGNOR curated interactions for PGK2 Gene

Drugs & Compounds for PGK2 Gene

(3) Drugs for PGK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
2-Phosphoglyceric acid Experimental Pharma 0
3-Phosphoglyceric acid Experimental Pharma 0

(2) Additional Compounds for PGK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Glyceric acid 1,3-biphosphate
  • 1,3-Biphosphoglycerate
  • 1,3-Biphosphoglyceric acid
  • 1,3-Bis-phosphoglycerate
  • 1,3-Bisphosphoglycerate
  • 1,3-Diphosphateglycerate
genes like me logo Genes that share compounds with PGK2: view

Transcripts for PGK2 Gene

mRNA/cDNA for PGK2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGK2 Gene

Phosphoglycerate kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGK2 Gene

No ASD Table

Relevant External Links for PGK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGK2 Gene

mRNA expression in normal human tissues for PGK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGK2 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for PGK2 Gene

This gene is overexpressed in Lung (23.3), Brain (16.3), and Testis (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGK2 Gene

SOURCE GeneReport for Unigene cluster for PGK2 Gene Hs.367727

mRNA Expression by UniProt/SwissProt for PGK2 Gene

Tissue specificity: Mainly found in round spermatids. Localized on the principle piece in the sperm (at protein level). Testis-specific. Expression significantly decreased in the testis of elderly men.
genes like me logo Genes that share expression patterns with PGK2: view

Primer Products

No data available for Protein tissue co-expression partners for PGK2 Gene

Orthologs for PGK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PGK2 35
  • 88.33 (n)
  • 89.45 (a)
(Canis familiaris)
Mammalia PGK2 35
  • 88.57 (n)
  • 90.17 (a)
-- 36
  • 86 (a)
(Mus musculus)
Mammalia Pgk2 35
  • 84.89 (n)
  • 85.85 (a)
Pgk2 16
Pgk2 36
  • 86 (a)
(Pan troglodytes)
Mammalia PGK2 35
  • 99.36 (n)
  • 99.52 (a)
PGK2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pgk2 35
  • 85.37 (n)
  • 86.57 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
-- 36
  • 82 (a)
-- 36
  • 83 (a)
-- 36
  • 83 (a)
-- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
(Gallus gallus)
Aves PGK1 36
  • 82 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
(Danio rerio)
Actinopterygii pgk1 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9961 37
  • 56 (a)
Pgk 37
  • 68 (a)
CG9961 36
  • 53 (a)
Pgk 36
  • 68 (a)
(Caenorhabditis elegans)
Secernentea T03F1.3 37
  • 69 (a)
pgk-1 36
  • 69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PGK1 36
  • 63 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PGK 35
  • 56.5 (n)
  • 50.65 (a)
(Glycine max)
eudicotyledons Gma.6263 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6705 35
(Oryza sativa)
Liliopsida Os02g0169300 35
  • 55.99 (n)
  • 50.9 (a)
Species with no ortholog for PGK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PGK2 Gene

Gene Tree for PGK2 (if available)
Gene Tree for PGK2 (if available)

Paralogs for PGK2 Gene

Paralogs for PGK2 Gene

(1) SIMAP similar genes for PGK2 Gene using alignment to 1 proteins: Pseudogenes for PGK2 Gene

genes like me logo Genes that share paralogs with PGK2: view

Variants for PGK2 Gene

Sequence variations from dbSNP and Humsavar for PGK2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11758714 -- 49,788,992(+) ataat(G/T)gggat upstream-variant-2KB
rs2840223 -- 49,788,884(+) tttgt(A/G)gttat upstream-variant-2KB
rs686612 -- 49,785,326(-) CAAAT(A/G)CCAGC downstream-variant-500B
rs72875753 -- 49,788,770(+) GCAAT(A/G)GAATA upstream-variant-2KB
rs143418445 -- 49,788,235(+) TACAG(C/T)TTTTT upstream-variant-2KB

Variation tolerance for PGK2 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PGK2 Gene

Disorders for PGK2 Gene

Relevant External Links for PGK2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PGK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGK2 Gene

Publications for PGK2 Gene

  1. Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene. (PMID: 3453121) McCarrey J.R. … Thomas K. (Nature 1987) 2 3 4 67
  2. Molecular cloning and structure of an autosomal processed gene for human phosphoglycerate kinase. (PMID: 3839763) Tani K. … Yoshida A. (Gene 1985) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Sequence-specific promoter elements regulate temporal-specific changes in chromatin required for testis-specific activation of the Pgk2 gene. (PMID: 24000349) Yang Z. … McCarrey J.R. (Reproduction 2013) 3

Products for PGK2 Gene

Sources for PGK2 Gene