PGK2 Gene
protein-coding GIFtS: 59
GCID: GC06M049753
|
|
phosphoglycerate kinase 2
| |
Aliases
for PGK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphoglycerate Kinase 21 2 | | EC 2.7.2.33 8 | | PGKPS1 2 | | PGK-21 | | Phosphoglycerate Kinase, Testis Specific2 3 | | DJ417L20.21 | | PGKB2 3 | | Phosphoglycerate Kinase Autosomal Pseudogene2 |
Export aliases for PGK2 gene to outside databasesPrevious GC identifers: GC06M049755 GC06M049800 GC06M049861 GC06M049483 |
Summaries
for PGK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PGK2:
This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressedspecifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functionalphosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate,during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.(provided by RefSeq,May 2010)
|
Genomic Views
for PGK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PGK2 gene promoter:
c-Fos AP-1 JunB Fra-1 FosB CUTL1 Roaz PPAR-alpha Nkx6-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for PGK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12.3 Ensembl cytogenetic band: 6p12.3 HGNC cytogenetic band: 6p12.3PGK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M049753: view genomic region
(about GC identifiers)
Start:
|
49,753,364 bp from pter |
End:
|
49,755,053 bp from pter |
Size:
|
1,690 bases |
Orientation:
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minus strand |
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Proteins
for PGK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205 (See
protein sequence)Recommended Name: Phosphoglycerate kinase 2 Size: 417 amino acids; 44796 Da
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: B2R6Y8 Q9H107Explore the universe of human proteins at neXtProt for PGK2: NX_P07205
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P07205
4/26 DME Specific Peptides for PGK2 (P07205) (see all 26)
PGK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_620061.2
ENSEMBL proteins: ENSP00000305995
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
NAS | -- |
PGK2 for ontologies About GeneDecksing
PGK2 Antibody Products:
Assay Products for PGK2: |
Protein
Domains /
Families
for PGK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PGK2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P07205ProtoNet protein and cluster: P07205 1 Blocks protein family: IPB001576 Phosphoglycerate kinase
UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205Similarity: Belongs to the phosphoglycerate kinase family |
Function
for PGK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205Catalytic activity: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate Genatlas biochemistry entry for PGK2:phosphoglycerate kinase 2,specifically expressed in spermatogenic cell,highly homologous to PGK1,glycolysis,energypathway,key enzyme for ATP generation
Enzyme Number (IUBMB): EC 2.7.2.31 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGK2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGK2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
PGK2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PGK2:
Animal Models:
Mouse knock-out Pgk2tm1Dao for PGK2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Pgk2):
PGK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PGK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glycolysis and gluconeogenesis (short map) | | | 2 | gluconeogenesis I | | | 3 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PGK2
1  GeneGo (Thomson Reuters) Pathway for PGK2
3  BioSystems Pathways for PGK2
2 
Kegg Pathways (Kegg details for PGK2):
UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5
PGK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PGK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for PGK2 (P072053 ENSP000003059954) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
PGK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PGK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PGK2
3 HMDB Compounds for PGK2 About this table
Search CenterWatch for drugs/clinical trials and news about PGK2
|
Transcripts
for PGK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PGK2 gene: NM_138733.4 Unigene Cluster for PGK2: Phosphoglycerate kinase 2 Hs.367727 [show with all ESTs]Unigene Representative Sequence: NM_1387331 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000304801(uc003ozu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGK2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PGK2 (NM_138733) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PGK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGK2 |
Additional cDNA sequence: AK312770.1 BC038843.1 2 DOTS entries: DT.91651170 DT.121343673 24/31 AceView cDNA sequences (see all 31): CD171670 BI825781 BP371280 BP369517 CD358467 BI832204 NM_138733 BG718080 BP369008 BP369088 BI827588 BX641875 AL042647 BM563802 BP370274 BP368944 BP369546 BI831239 BI831468 BU568460 CD300101 BI827535 BI464092 BG717359
GeneLoc Exon Structure
|
Expression
for PGK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PGK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTTAAGT
About this image
See PGK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PGK2
SOURCE GeneReport for Unigene cluster: Hs.367727
UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205Tissue specificity: Testis specific
SABiosciences Expression via Pathway-Focused PCR Array including PGK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PGK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PGK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGK2 |
Orthologs
for PGK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for PGK2 gene from 8/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NU17_CHICK6 |
phosphoglycerate kinase 1 |
83(a) |
1 → many |
4(13036123-13047321) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
83(a) |
1 → many |
GL343465.1(735749-749591) |
zebrafish
(Danio rerio) |
Actinopterygii |
pgk16 |
phosphoglycerate kinase 1 |
82(a) |
1 → many |
21(36771669-36787616) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pgk3 |
glycolysis phosphoglycerate kinase |
68(a)
(best of 2) |
|
23A3 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
T03F1.33 |
phosphoglycerate kinase |
69(a) |
|
I(3867554-3868959) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PGK6PGK16(see all 3) |
phosphoglycerate kinase 1(see all 3) |
48(a)40(a)(see all 3) |
possible orthologpossible ortholog(see all 3) |
1(29924023-29926582) 3(4060971-4063306) |
rice
(Oryza sativa) |
Liliopsida |
AK070041.12 |
-- |
75.66(n) |
|
AK070041.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
pgk6 |
phosphoglycerate kinase |
36(a) |
1 → many |
Chromosome(3069481-3070644) |
ENSEMBL Gene Tree for PGK2 (if available)
TreeFam Gene Tree for PGK2 (if available) |
Paralogs
for PGK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PGK2 gene
- PGK12
1 SIMAP similar gene for PGK2 using alignment to 1 protein entry: PGK2_HUMAN:PGK1
PGK2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PGK2
PGOHUM00000234519 PGOHUM00000241367
|
Genomic Variants
for PGK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PGK2 (49753364 - 49755053 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PGK2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGK2 |
|
Disorders
/ Diseases
for PGK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PGK2 for disorders About GeneDecksing
OMIM gene information: 172270
OMIM disorders: --
8  diseases for PGK2: About MalaCardsskin tag hemolytic anemia anemia ovarian cancer
pneumonia tuberculosis malaria mycobacterium tuberculosis
Export disorders for PGK2 gene to outside databases
|
Publications
for PGK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PGK2 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with PGK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene. (PubMed id 3453121)1, 2, 3 McCarrey J.R. and Thomas K. (1987)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Molecular cloning and structure of an autosomal processed gene for human phosphoglycerate kinase. (PubMed id 3839763)1, 3 Tani K....Yoshida A. (1985)
- Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Frequent and recent retrotransposition of orthologous genes plays a role in the evolution of sperm glycolytic enzymes. (PubMed id 20459611)1 Vemuganti S.A....O'Brien D.A. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for PGK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PGK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PGK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PGK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PGK2 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Phosphoglycerate_kinase |
|
| | |
About This Section
| Patent Information for PGK2 gene:
Search GeneIP for patents involving PGK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PGK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PGK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGK2 |
| |
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