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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGK2 Gene

protein-coding   GIFtS: 61
GCID: GC06M049753

Phosphoglycerate Kinase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphoglycerate Kinase 21 2     PGKPS2
Phosphoglycerate Kinase, Testis Specific2 3     dJ417L20.22
PGKB2 3     Phosphoglycerate Kinase Autosomal Pseudogene2
EC 2.7.2.33 8     

External Ids:    HGNC: 88981   Entrez Gene: 52322   Ensembl: ENSG000001709507   OMIM: 1722705   UniProtKB: P072053   

Export aliases for PGK2 gene to outside databases

Previous GC identifers: GC06M049755 GC06M049800 GC06M049861 GC06M049483


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGK2 Gene:
This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed
specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional
phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to
3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of
spermatogenesis.(provided by RefSeq, May 2010)

GeneCards Summary for PGK2 Gene: 
PGK2 (phosphoglycerate kinase 2) is a protein-coding gene. Diseases associated with PGK2 include skin tag, and hemolytic anemia, and among its related super-pathways are Glycolysis and gluconeogenesis (short map) and Biosynthesis of amino acids. GO annotations related to this gene include phosphoglycerate kinase activity and ATP binding. An important paralog of this gene is PGK1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGK2 gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   CUTL1   Roaz   PPAR-alpha   Nkx6-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPGK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PGK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

PGK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGK2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M049753:  view genomic region     (about GC identifiers)

Start:
49,753,364 bp from pter      End:
49,755,053 bp from pter
Size:
1,690 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205 (See protein sequence)
Recommended Name: Phosphoglycerate kinase 2  
Size: 417 amino acids; 44796 Da
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: B2R6Y8 Q9H107

Explore the universe of human proteins at neXtProt for PGK2: NX_P07205

Explore proteomics data for PGK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07205

  • 4/26 DME Specific Peptides for PGK2 (P07205) (see all 26)
     ITNNQRI  PSIKYCL  SLFDEEG  LLENLRF 

    PGK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PGK2 Protein Expression
    REFSEQ proteins: NP_620061.2  
    ENSEMBL proteins: 
     ENSP00000305995  

    Human Recombinant Protein Products for PGK2: 
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    OriGene MassSpec for PGK2 
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    GenScript Custom Purified and Recombinant Proteins Services for PGK2
    Novus Biologicals PGK2 Proteins
    Novus Biologicals PGK2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PGK2
    Cloud-Clone Corp. Proteins for PGK2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol NAS--

    PGK2 for ontologies           About GeneDecksing



    PGK2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for PGK2 

    Assay Products for PGK2: 
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    Cloud-Clone Corp. ELISAs for PGK2 
    Cloud-Clone Corp. CLIAs for PGK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001576 Phosphoglycerate_kinase
     IPR015824 Phosphoglycerate_kinase_N
     IPR015901 Phosphoglycerate_kinase_C
     IPR015911 Phosphoglycerate_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P07205

    ProtoNet protein and cluster: P07205

    1 Blocks protein domain: IPB001576 Phosphoglycerate kinase

    UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205
    Similarity: Belongs to the phosphoglycerate kinase family


    PGK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGK2_HUMAN, P07205
    Catalytic activity: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate

         Genatlas biochemistry entry for PGK2:
    phosphoglycerate kinase 2,specifically expressed in spermatogenic cell,highly homologous to PGK1,glycolysis,energy
    pathway,key enzyme for ATP generation

         Enzyme Number (IUBMB): EC 2.7.2.31 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004618phosphoglycerate kinase activity NAS3453121
    GO:0005524ATP binding ISS--
         
    PGK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PGK2:
     Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pgk2):
     reproductive system 

    PGK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pgk2tm1Dao for PGK2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PGK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PGK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PGK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PGK2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGK2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PGK2:
    hsa-miR-633
    SwitchGear 3'UTR luciferase reporter plasmidPGK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PGK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGK2

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PGK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and gluconeogenesis (short map)0.60
    Glycolysis / Gluconeogenesis0.46
    Glycolysis and Gluconeogenesis0.60
    2Carbon metabolism
    Carbon metabolism0.37
    Biosynthesis of amino acids0.37
    3Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PGK2
        Glycolysis and gluconeogenesis (short map)


    1 GeneGo (Thomson Reuters) Pathway for PGK2
        Glycolysis and gluconeogenesis (short map)

    1 BioSystems Pathway for PGK2
        Glycolysis and Gluconeogenesis



    4         Kegg Pathways  (Kegg details for PGK2):
        Glycolysis / Gluconeogenesis
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids

    UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205
    Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5


    PGK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PGK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for PGK2 (P072053 ENSP000003059954) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    BPGMENSP000003420324STRING: ENSP00000342032
    PGAM2ENSP000002972834STRING: ENSP00000297283
    PGAM4ENSP000004121894STRING: ENSP00000412189
    COPAENSP000003570484STRING: ENSP00000357048
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006096glycolysis NAS3453121
    GO:0016310phosphorylation NAS3453121

    PGK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGK2

    3 HMDB Compounds for PGK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Phosphoglyceric acid2-(dihydrogen phosphate)Glycerate (see all 16)2553-59-5--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about PGK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PGK2 gene: 
    NM_138733.4  

    Unigene Cluster for PGK2:

    Phosphoglycerate kinase 2
    Hs.367727  [show with all ESTs]
    Unigene Representative Sequence: NM_138733
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304801(uc003ozu.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGK2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PGK2:
    hsa-miR-633
    SwitchGear 3'UTR luciferase reporter plasmidPGK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PGK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGK2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PGK2 (NM_138733)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGK2
    Sirion Biotech Customized lentivirus for stable overexpression of PGK2 
                         Customized lentivirus expression plasmids for stable overexpression of PGK2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PGK2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGK2

    Additional mRNA sequence: 

    AK312770.1 BC038843.1 

    2 DOTS entries:

    DT.91651170  DT.121343673 

    24/31 AceView cDNA sequences (see all 31):

    BP369517 CD171670 CD358467 BI825781 BP371280 BI827535 BC038843 BI831239 
    BX641875 BG717359 BM563802 BI832204 BP369008 BI831364 BU568460 BP369088 
    BP370274 BI831468 BG718080 BI464092 AL042647 BP368944 BP369546 BI827588 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGK2 expression in normal human tissues (normalized intensities)      PGK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTTAAGT
    PGK2 Expression
    About this image


    PGK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Testis (Reproductive System)    fully expand to see all 6 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
             seminal vesicle ; glandular cells   
             sperm   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Kidney (Urinary System)
             kidney ; cells in tubules   
     
     Thyroid (Endocrine System)
             parathyroid gland ; glandular cells   

    See PGK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGK2

    SOURCE GeneReport for Unigene cluster: Hs.367727

    UniProtKB/Swiss-Prot: PGK2_HUMAN, P07205
    Tissue specificity: Testis specific

        SABiosciences Expression via Pathway-Focused PCR Array including PGK2: 
              Glucose Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PGK2 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pgk21 , 5 phosphoglycerate kinase 21, 5 84.89(n)1
    85.85(a)1
      17 (19.44 cM)5
    186631  NM_031190.21  NP_112467.21 
     402070185 
    chicken
    (Gallus gallus)
    Aves PGK16
    phosphoglycerate kinase
    82(a)
    1 → many
    4(12898194-12909392)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Phosphoglycerate kinase
    83(a)
    1 → many
    GL343465.1(735609-750645)
    zebrafish
    (Danio rerio)
    Actinopterygii pgk16
    phosphoglycerate kinase 1
    81(a)
    1 → many
    21(36771669-36787616)
    fruit fly
    (Drosophila melanogaster)
    Insecta Pgk3 glycolysis phosphoglycerate kinase 68(a)
    (best of 2)
      23A3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T03F1.33 phosphoglycerate kinase 69(a)   I(3867554-3868959)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PGK16
    3-phosphoglycerate kinase, catalyzes transfer of h...
    62(a)
    1 → many
    III(137746-138996)
    soybean
    (Glycine max)
    eudicotyledons Gma.62632 Transcribed sequence with moderate similarity to protein more 75.65(n)  
    rice
    (Oryza sativa)
    Liliopsida AK070041.12   -- 75.66(n)    AK070041.1 


    ENSEMBL Gene Tree for PGK2 (if available)
    TreeFam Gene Tree for PGK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGK2 gene
    PGK12  
    1 SIMAP similar gene for PGK2 using alignment to 1 protein entry:     PGK2_HUMAN:
    PGK1

    PGK2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PGK2
    PGOHUM00000234519 PGOHUM00000241367


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 SNPs in PGK2 are shown (see all 117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853816641,2
    --49752879(+) TTCCCA/TTTATT 1 -- ds50010--------
    rs1440980951,2
    --49752884(+) ATTATG/TAAACC 1 -- ds50010--------
    rs1459910131,2
    --49752978(+) GCCTTA/CAAAAT 1 -- ds50010--------
    rs1909742031,2
    --49752987(+) ATAAAA/GCAATT 1 -- ds50010--------
    rs1486942071,2
    --49753010(+) CTTGGG/TTTTAA 1 -- ds50010--------
    rs1161472501,2
    C,F--49753029(+) TCTTTT/CTCTAG 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs6866121,2
    C,H--49753039(-) CAAATG/ACCAGC 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 422
    rs1835048161,2
    --49753170(+) TATTTA/GGTATA 1 -- ds50010--------
    rs794246091,2
    C,F--49753259(+) ATTTAT/CTGTTT 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1860925191,2
    --49753333(+) ATGAAA/GCAATA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PGK2 (49753364 - 49755053 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PGK2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PGK2
    DNA2.0 Custom Variant and Variant Library Synthesis for PGK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 172270    OMIM disorders: --

    6 diseases for PGK2:    About MalaCards
    skin tag    hemolytic anemia    pneumonia    tuberculosis
    anemia    ovarian cancer


    PGK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PGK2

    Export disorders for PGK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGK2 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with PGK2)
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    1. Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene. (PubMed id 3453121)1, 2, 3 McCarrey J.R. and Thomas K. (1987)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Molecular cloning and structure of an autosomal processed gene for human phosphoglycerate kinase. (PubMed id 3839763)1, 3 Tani K....Yoshida A. (1985)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5232 HGNC: 8898 AceView: PGK2 Ensembl:ENSG00000170950 euGenes: HUgn5232
    ECgene: PGK2 Kegg: 5232 H-InvDB: PGK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGK2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Phosphoglycerate_kinase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PGK2 gene:
    Search GeneIP for patents involving PGK2

    GeneCards and IP:
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