Aliases for PGGT1B Gene
External Ids for PGGT1B Gene
Previous GeneCards Identifiers for PGGT1B Gene
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
GeneCards Summary for PGGT1B Gene
PGGT1B (Protein Geranylgeranyltransferase Type I, Beta Subunit) is a Protein Coding gene. Among its related pathways are G-protein signaling_RhoA regulation pathway and G-protein signaling_Regulation of RAC1 activity. GO annotations related to this gene include drug binding and protein geranylgeranyltransferase activity. An important paralog of this gene is RABGGTB.
UniProtKB/Swiss-Prot for PGGT1B Gene
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.