Aliases for PGF Gene
External Ids for PGF Gene
Previous HGNC Symbols for PGF Gene
Previous GeneCards Identifiers for PGF Gene
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
GeneCards Summary for PGF Gene
PGF (Placental Growth Factor) is a Protein Coding gene. Diseases associated with PGF include placental insufficiency and twin-to-twin transfusion syndrome. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is VEGFA.
UniProtKB/Swiss-Prot for PGF Gene
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.