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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGF Gene

protein-coding   GIFtS: 65
GCID: GC14M075408

Placental Growth Factor

(Previous names: placental growth factor-like, placental growth factor, vascular...)
(Previous symbol: PGFL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Placental Growth Factor1 2     Placental Growth Factor-Like1
PGFL1 2 3     D12S19002
PLGF2 3 5     PlGF-22
Placental Growth Factor, Vascular Endothelial Growth Factor-Related
Protein1 2
     SHGC-107602
Placenta Growth Factor1 2     PlGF3

External Ids:    HGNC: 88931   Entrez Gene: 52282   Ensembl: ENSG000001196307   OMIM: 6011215   UniProtKB: P497633   

Export aliases for PGF gene to outside databases

Previous GC identifers: GC14M072935 GC14M069225 GC14M073398 GC14M074478 GC14M055576


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGF Gene:
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor.
Alternatively spliced transcripts encoding different isoforms have been found for this gene.(provided by RefSeq,
Jun 2011)

GeneCards Summary for PGF Gene: 
PGF (placental growth factor) is a protein-coding gene. Diseases associated with PGF include cancer-associated retinopathy, and placental insufficiency, and among its related super-pathways are Focal Adhesion and VEGF Family Ligands and Receptor Interactions. GO annotations related to this gene include growth factor activity and protein homodimerization activity. An important paralog of this gene is VEGFA.

UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763
Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and
migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in
a heparin-dependent manner. Also promotes cell tumor growth

Gene Wiki entry for PGF (Placental growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGF gene promoter:
         PPAR-gamma1   p53   STAT3   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPGF promoter sequence
   Search SABiosciences Chromatin IP Primers for PGF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

PGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGF gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M075408:  view genomic region     (about GC identifiers)

Start:
75,408,533 bp from pter      End:
75,422,487 bp from pter
Size:
13,955 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763 (See protein sequence)
Recommended Name: Placenta growth factor precursor  
Size: 221 amino acids; 24789 Da
Subunit: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Isoform PlGF-3 is
found both as homodimer and as monomer
Subcellular location: Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached
unless released by heparin
2 PDB 3D structures from and Proteopedia for PGF:
1FZV (3D)        1RV6 (3D)    
Secondary accessions: Q07101 Q9BV78 Q9Y6S8
Alternative splicing: 3 isoforms:  P49763-1   P49763-2   P49763-3   

Explore the universe of human proteins at neXtProt for PGF: NX_P49763

Explore proteomics data for PGF at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49763

  • PGF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PGF Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001193941.1  NP_002623.2  

    ENSEMBL proteins: 
     ENSP00000451040   ENSP00000451413   ENSP00000238607   ENSP00000385365  
    Reactome Protein details: P49763
    Human Recombinant Protein Products for PGF: 
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    R&D Systems Recombinant & Natural Proteins for PGF (PlGF-2, PlGF-3, PlGF)
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    OriGene Protein Over-expression Lysate for PGF
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    Novus Biologicals PGF Proteins
    Novus Biologicals PGF Lysate
    Sino Biological Recombinant Protein for PGF
    Sino Biological Cell Lysate for PGF 
    ProSpec Recombinant Protein for PGF
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0016020membrane IEA--

    PGF for ontologies           About GeneDecksing



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    Assay Products for PGF: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023581 PD_growth_factor_CS
     IPR000072 PD_growth_factor

    Graphical View of Domain Structure for InterPro Entry P49763

    ProtoNet protein and cluster: P49763

    1 Blocks protein domain: IPB000072 Platelet-derived growth factor (PDGF)

    UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763
    Domain: Isoform PlGF-2 contains a basic insert which acts as a cell retention signal
    Similarity: Belongs to the PDGF/VEGF growth factor family


    PGF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLGF_HUMAN, P49763
    Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and
    migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in
    a heparin-dependent manner. Also promotes cell tumor growth

         Genatlas biochemistry entry for PGF:
    placenta growth factor,angiogenic,vascular endothelial growth factor related

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IMP--
    GO:0008201heparin binding IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    PGF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PGF:
     Increased G1 DNA content 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pgf):
     adipose tissue  cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism 
     immune system  integument  respiratory system  tumorigenesis  vision/eye 

    PGF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pgftm1Pec for PGF

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PGF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PGF 
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    hsa-miR-4291 hsa-miR-4272 hsa-miR-449a hsa-miR-520a-5p hsa-miR-124 hsa-miR-149 hsa-miR-506 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidPGF 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGF
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PGF About   (see all 20)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    2VEGF Family Ligands and Receptor Interactions
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF-family signaling0.36
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PGF
        Development VEGF-family signaling

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PGF (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for PGF
        Development VEGF-family signaling

    2 BioSystems Pathways for PGF
        Focal Adhesion
    VEGFR1 specific signals

    1 Sino Biological Pathway for PGF 
        VEGF Signaling

    4        Reactome Pathways for PGF
        Signaling by VEGF
    VEGF binds to VEGFR leading to receptor dimerization
    VEGF ligand-receptor interactions
    Signal Transduction


    3         Kegg Pathways  (Kegg details for PGF):
        PI3K-Akt signaling pathway
    Focal adhesion
    Pathways in cancer


    PGF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/17 Interacting proteins for PGF (P497633 ENSP000002386074) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLT1P179483, ENSP000002823974I2D: score=6 STRING: ENSP00000282397
    NRP2O604623, ENSP000003535824I2D: score=3 STRING: ENSP00000353582
    VEGFAP156923, ENSP000003611254I2D: score=3 STRING: ENSP00000361125
    NRP1O147863, ENSP000002653714I2D: score=2 STRING: ENSP00000265371
    NFICP086513I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0002040sprouting angiogenesis IEA--
    GO:0007165signal transduction TAS9467961

    PGF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PGF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGF (PLGF)

    1 DrugBank Compound for PGF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AfliberceptAVE 0005 (see all 6)862111-32-8targetbinder22813448

    10/21 Novoseek inferred chemical compound relationships for PGF gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 89.6 529 10606981 (9), 16814647 (8), 11254400 (6), 11470864 (5) (see all 99)
    tyrosine 69.7 100 19943826 (7), 8919031 (1), 15284201 (1), 15886253 (1) (see all 80)
    sunitinib 41 3 19513511 (1), 17605814 (1), 18669461 (1)
    matrigel 23.1 1 12673673 (1)
    pd 98,059 22.2 4 19035132 (1), 17028267 (1), 18558410 (1)
    heparin 21.5 18 10527820 (3), 8148155 (2), 9712843 (1), 12613545 (1) (see all 9)
    nitric oxide 7.95 17 17028267 (4), 19035132 (2), 11750869 (1), 18558410 (1) (see all 9)
    wortmannin 5.61 3 12689930 (1), 18558410 (1)
    oxygen 4.94 18 15284201 (3), 7541940 (2), 17956952 (2), 19712973 (2) (see all 8)
    lipid 1.72 1 17159877 (1)

    Search CenterWatch for drugs/clinical trials and news about PGF / PLGF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PGF gene (2 alternative transcripts): 
    NM_001207012.1  NM_002632.5  

    Unigene Cluster for PGF:

    Placental growth factor
    Hs.252820  [show with all ESTs]
    Unigene Representative Sequence: AK023843
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555567(uc001xqz.3 uc001xrb.3) ENST00000553716 ENST00000238607
    ENST00000557748 ENST00000405431 ENST00000555253 ENST00000556939(uc010ase.2 uc010asf.2)
    ENST00000555234
    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PGF (see all 23):
    hsa-miR-4291 hsa-miR-4272 hsa-miR-449a hsa-miR-520a-5p hsa-miR-124 hsa-miR-149 hsa-miR-506 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidPGF 3' UTR sequence
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGF

    Additional mRNA sequence: 

    AK023843.1 AK057973.1 AK309886.1 AK310608.1 AK310886.1 BC001422.2 BC007255.1 BC007789.2 
    BT007182.1 BX248289.1 S72960.1 X54936.1 

    8 DOTS entries:

    DT.454164  DT.100787535  DT.91997668  DT.120764292  DT.100025837  DT.75161740  DT.100807163  DT.95275183 

    24/201 AceView cDNA sequences (see all 201):

    CR593434 BU150305 CF529499 AA299697 CR625775 AA369322 BQ014455 AW771163 
    T53764 BQ070531 CR611238 AA987436 BE301780 CR612112 BQ647895 CR611071 
    R66396 CR604743 CR626064 AI379465 CR593571 CR620888 BX248289 CR592863 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PGF    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -                                       
    SP2:              -                                       
    SP3:                                                      


    ECgene alternative splicing isoforms for PGF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGF expression in normal human tissues (normalized intensities)      PGF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTCCTAA
    PGF Expression
    About this image


    PGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 12 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Pulmonary Artery Endothelial Cells (HPAEC)   
             huvec   
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Zeugopod Periosteum
             HyStem+BMP4-induced MEL2 cells
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Double Positive Thymocytes Thymus
             cd31+ cells   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells

    See PGF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGF

    SOURCE GeneReport for Unigene cluster: Hs.252820

    UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763
    Tissue specificity: While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8
    week) placenta and only PlGF-1 is found in the colon and mammary carcinomas

        SABiosciences Expression via Pathway-Focused PCR Arrays including PGF (see all 7): 
              Growth Factors in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PGF gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pgf1 , 5 placental growth factor1, 5 73.51(n)1
    66.89(a)1
      12 (39.58 cM)5
    186541  NM_008827.21  NP_032853.11 
     851666415 
    chicken
    (Gallus gallus)
    Aves LOC7718321 placenta growth factor-like 71.17(n)
    55.86(a)
      771832  XM_001235058.2  XP_001235059.2 
    lizard
    (Anolis carolinensis)
    Reptilia PGF6
    Uncharacterized protein
    50(a)
    1 ↔ 1
    1(22691163-22697207)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5574681 placenta growth factor-like 60.69(n)
    53.1(a)
      557468  XM_680548.4  XP_685640.4 


    ENSEMBL Gene Tree for PGF (if available)
    TreeFam Gene Tree for PGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGF gene
    VEGFA2  VEGFB2  
    3 SIMAP similar genes for PGF using alignment to 3 protein entries:     PLGF_HUMAN (see all proteins):
    VEGF    VEGFA    VEGFB

    PGF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/398 SNPs in PGF are shown (see all 398)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617594141,2
    C--56399810(-) GAGACT/CGTTCC 2 -- ds50012Minor allele frequency- C:0.01NS 92
    rs1913239041,2
    --56399836(+) GCCACC/TGAGAC 2 -- ds50010--------
    rs1821315891,2
    --56399924(+) GTGAAA/GGCAGA 2 -- ds50010--------
    rs1383004051,2
    C--56399970(+) AGCCAA/GGCCTC 2 -- ds50010--------
    rs1496420951,2
    C--56400002(+) TAACTC/TTCCAT 2 -- ds50010--------
    rs1443184701,2
    C--56400035(+) CTAAGC/TGTCCT 2 -- ds50010--------
    rs1179133451,2
    F--56400079(+) AACATG/ATTGTC 2 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1409521451,2
    C--56400107(+) CTCTCA/GTCGAC 2 -- ds50010--------
    rs1865620641,2
    --56400117(+) CTGAGC/TGAGGC 2 -- ds50010--------
    rs617594131,2
    C,F--56400147(-) TCTCCG/AAGCCT 2 -- ds50013Minor allele frequency- A:0.03NS WA 210

    HapMap Linkage Disequilibrium report for PGF (75408533 - 75422487 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PGF: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PGF
    DNA2.0 Custom Variant and Variant Library Synthesis for PGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601121    OMIM disorders: --

    20/85 diseases for PGF (see all 85):    About MalaCards
    cancer-associated retinopathy    placental insufficiency    epithelioid hemangioendothelioma    placental abruption
    middle ear cholesteatoma    severe pre-eclampsia    sickle cell disease    myxoid liposarcoma
    pre-eclampsia    intermittent claudication    hemangioendothelioma    eclampsia
    endometritis    proteinuria    critical limb ischemia    malignant pleural mesothelioma
    sickle cell anemia    diabetic retinopathy    ectopic pregnancy    ischemic heart disease

    4 diseases from the University of Copenhagen DISEASES database for PGF:
    Hypertension     Endometritis     Proteinuria     Cancer

    PGF for disorders           About GeneDecksing

    10/48 Novoseek inferred disease relationships for PGF gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 86.7 255 17460385 (7), 17403407 (7), 15117604 (6), 15632339 (6) (see all 87)
    neovascularization 70.1 24 12714333 (1), 16754748 (1), 19505392 (1), 15312686 (1) (see all 20)
    intrauterine growth retardation 62.2 4 19536710 (1), 19996864 (1), 15591804 (1), 18058842 (1)
    pregnancy complications 56.4 2 19536710 (1), 18175241 (1)
    proteinuria 50.1 10 19165674 (2), 15632339 (2), 15117604 (1), 17553534 (1) (see all 5)
    severe pre-eclampsia 48.8 1 15938782 (1)
    sickle cell disease 39.7 3 20351105 (1), 20040765 (1), 19010294 (1)
    tumors 35.1 84 12673673 (5), 19805167 (4), 16618713 (4), 7478581 (4) (see all 39)
    systemic hypertension 34.2 5 17371983 (1), 15663401 (1), 16711023 (1), 18648513 (1) (see all 5)
    inflammation 33.6 29 16412852 (3), 18411415 (2), 17157858 (2), 19010294 (2) (see all 19)

    Genetic Association Database (GAD): PGF
    Human Genome Epidemiology (HuGE) Navigator: PGF (3 documents)

    Export disorders for PGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGF gene, integrated from 9 sources (see all 459):
    (articles sorted by number of sources associating them with PGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14. (PubMed id 7681160)1, 2, 3, 9 Maglione D.... Persico M.G. (1993)
    2. A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. (PubMed id 8148155)1, 2, 9 Hauser S.D. and Weich H.A. (1993)
    3. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. (PubMed id 1924389)1, 2, 9 Maglione D.... Persico M.G. (1991)
    4. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF . (PubMed id 21215706)1, 2 Rolny C....Carmeliet P. (2011)
    5. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    6. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    9. The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution. (PubMed id 11069911)1, 2 Iyer S.... Acharya K.R. (2001)
    10. Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing. (PubMed id 9207183)1, 2 Cao Y.... Cao Y. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5228 HGNC: 8893 AceView: PGF Ensembl:ENSG00000119630 euGenes: HUgn5228
    ECgene: PGF Kegg: 5228 H-InvDB: PGF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PGF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PGF gene:
    Search GeneIP for patents involving PGF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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