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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PGF Gene

protein-coding GIFtS: 66
GCID: GC14M075408

placental growth factor

(Previous names: placental growth factor-like, placental growth factor,...)
(Previous symbol: PGFL)

Explore 91 diseases affiliated with
PGF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Placental Growth Factor¹ ²		SHGC-10760¹ ²
PLGF¹ ² ³ ⁵		Placental Growth Factor, Vascular Endothelial Growth Factor-Related Protein¹ ²
PGFL¹ ² ³		PlGF¹ ³
D12S1900¹ ²		Placental Growth Factor-Like¹
PlGF-2¹ ²		Placenta Growth Factor²

External Ids:	HGNC: 8893¹	Entrez Gene: 5228²	Ensembl: ENSG00000119630⁷	OMIM: 601121⁵	UniProtKB: P49763³

Export aliases for PGF gene to outside databases

Previous GC identifers: GC14M072935 GC14M069225 GC14M073398 GC14M074478 GC14M055576

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGF:

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor.

Alternatively spliced transcripts encoding different isoforms have been found for this gene.(provided by RefSeq, Jun

2011)

UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763

Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and

migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a

heparin-dependent manner. Also promotes cell tumor growth

Gene Wiki entry for PGF (Placental growth factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PGF gene promoter:
PPAR-gamma1 p53 STAT3 PPAR-gamma2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PGF promoter sequence

Search SABiosciences Chromatin IP Primers for PGF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

PGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGF gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M075408: view genomic region (about GC identifiers)

Start:	75,408,537 bp from pter	End:	75,422,487 bp from pter
Size:	13,951 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763 (See protein sequence)

Recommended Name: Placenta growth factor precursor

Size: 221 amino acids; 24789 Da

Subunit: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Isoform PlGF-3 is found

both as homodimer and as monomer

Subcellular location: Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless

released by heparin

2 PDB 3D structures from and Proteopedia for PGF:

1FZV (3D)

1RV6 (3D)

Secondary accessions: Q07101 Q9BV78 Q9Y6S8

Alternative splicing: 3 isoforms: P49763-1 P49763-2 P49763-3

Explore the universe of human proteins at neXtProt for PGF: NX_P49763

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49763

PGF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001193941.1 NP_002623.2

ENSEMBL proteins:

ENSP00000451040 ENSP00000451413 ENSP00000238607 ENSP00000385365

Reactome Protein details: P49763
Human Recombinant Protein Products:

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	Novus Biologicals PGF Proteins Novus Biologicals PGF Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PGF
	Uscn Proteins for PGF

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0016020	membrane	IEA	--

PGF for ontologies About GeneDecksing

PGF Antibody Products:

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	Uscn Antibodies for PGF
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Assay Products for PGF:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PGF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PGF for domains About GeneDecksing

2 InterPro domains/families:

IPR023581 PD_growth_factor_CS

IPR000072 PD_growth_factor

Graphical View of Domain Structure for InterPro Entry P49763

ProtoNet protein and cluster: P49763

1 Blocks protein family: IPB000072 Platelet-derived growth factor (PDGF)

UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763

Domain: Isoform PlGF-2 contains a basic insert which acts as a cell retention signal

Similarity: Belongs to the PDGF/VEGF growth factor family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763

Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and

migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a

heparin-dependent manner. Also promotes cell tumor growth

Genatlas biochemistry entry for PGF:

placenta growth factor,angiogenic,vascular endothelial growth factor related

miRNA Products:		OriGene 3'-UTR Clone: PGF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGF
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PGF (see all 23):
		hsa-miR-4291 hsa-miR-4272 hsa-miR-449a hsa-miR-520a-5p hsa-miR-124 hsa-miR-149 hsa-miR-506 hsa-miR-3121-3p

		SwitchGear 3'UTR luciferase reporter plasmid: PGF 3' UTR sequence

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PGF

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PGF
		Search LifeMap BioReagents cell lines for PGF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGF

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008083	growth factor activity	IMP	--
GO:0008201	heparin binding	IEA	--
GO:0042803	protein homodimerization activity	IEA	--
GO:0046982	protein heterodimerization activity	IEA	--

PGF for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PGF:

Increased G1 DNA content

Animal Models:
Mouse knock-out Pgf^tm1Pec for PGF
10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pgf):

adipose tissue	cardiovascular system	embryogenesis	growth/size	homeostasis/metabolism
immune system	integument	respiratory system	tumorigenesis	vision/eye

PGF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PGF

Development VEGF-family signaling

5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PGF (see all 55)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 GeneGo (Thomson Reuters) Pathway for PGF

Development VEGF-family signaling

2 BioSystems Pathways for PGF

	Focal Adhesion
	VEGFR1 specific signals

4 Reactome Pathways for PGF

	Signaling by VEGF
	VEGF binds to VEGFR leading to receptor dimerization
	VEGF ligand-receptor interactions
	Signal Transduction

5/7 Kegg Pathways (Kegg details for PGF) (see all 7):

	mTOR signaling pathway
	Focal adhesion
	Pathways in cancer
	Renal cell carcinoma
	Pancreatic cancer

PGF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PGF

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/17 Interacting proteins for PGF (P49763³ ENSP00000238607⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FLT1	P17948³, ENSP00000282397⁴	I2D: score=6 STRING: ENSP00000282397
NRP2	O60462³, ENSP00000353582⁴	I2D: score=3 STRING: ENSP00000353582
VEGFA	P15692³, ENSP00000361125⁴	I2D: score=3 STRING: ENSP00000361125
NRP1	O14786³, ENSP00000265371⁴	I2D: score=2 STRING: ENSP00000265371
NFIC	P08651³	I2D: score=1

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	--	--
GO:0001658	branching involved in ureteric bud morphogenesis	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--
GO:0002040	sprouting angiogenesis	IEA	--

PGF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PGF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PGF
10/21 Novoseek chemical compound relationships for PGF gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	89.6	529	10606981 (9), 16814647 (8), 11254400 (6), 11470864 (5) (see all 99)
tyrosine	69.7	100	19943826 (7), 8919031 (1), 15284201 (1), 15886253 (1) (see all 80)
sunitinib	41	3	19513511 (1), 17605814 (1), 18669461 (1)
matrigel	23.1	1	12673673 (1)
pd 98,059	22.2	4	19035132 (1), 17028267 (1), 18558410 (1)
heparin	21.5	18	10527820 (3), 8148155 (2), 9712843 (1), 12613545 (1) (see all 9)
nitric oxide	7.95	17	17028267 (4), 19035132 (2), 11750869 (1), 18558410 (1) (see all 9)
wortmannin	5.61	3	12689930 (1), 18558410 (1)
oxygen	4.94	18	15284201 (3), 7541940 (2), 17956952 (2), 19712973 (2) (see all 8)
lipid	1.72	1	17159877 (1)

Search CenterWatch for drugs/clinical trials and news about PGF / PLGF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PGF gene (2 alternative transcripts):

NM_001207012.1 NM_002632.5

Unigene Cluster for PGF:

Placental growth factor

Hs.252820 [show with all ESTs]

Unigene Representative Sequence: AK023843

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000555567(uc001xqz.3 uc001xrb.3) ENST00000553716 ENST00000238607

ENST00000557748 ENST00000405431 ENST00000555253 ENST00000555077 ENST00000556939(uc010ase.2 uc010asf.2)

ENST00000555234

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGF
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate PGF (see all 23):
		hsa-miR-4291 hsa-miR-4272 hsa-miR-449a hsa-miR-520a-5p hsa-miR-124 hsa-miR-149 hsa-miR-506 hsa-miR-3121-3p

		SwitchGear 3'UTR luciferase reporter plasmid: PGF 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: PGF (NM_002632)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGF

Additional cDNA sequence:

AK023843.1 AK057973.1 AK309886.1 AK310608.1 AK310886.1 BC001422.2 BC007255.1 BC007789.2

BT007182.1 BX248289.1 S72960.1 X54936.1

8 DOTS entries:

DT.454164 DT.100787535 DT.91997668 DT.120764292 DT.100025837 DT.75161740 DT.100807163 DT.95275183

24/201 AceView cDNA sequences (see all 201):

AI220900 CR592863 BQ647895 R66396 T53764 BU150305 CR598213 CR593571

AI379465 BQ070531 BQ014455 AA299697 BQ893335 BX248289 CR611238 CR593434

AL543185 AA987436 T54157 CF529499 AW771163 AA369322 BE301780 CR625775

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PGF About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7
SP1:					-
SP2:					-
SP3:

ECgene alternative splicing isoforms for PGF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PGF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCTCCTAA

About this image

PGF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Head Mesenchyme

Branchial Arch 1

Paraxial Mesoderm Cells

Bone, Skeletal Muscle

Bone

Mandibular Process

Bone

Zeugopod Periosteum

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

Syncytiotrophoblast-like cells (Generation of syncyt...)

Primitive gut tube-like cells (A scalable, suspensi...)

HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)

Bone, Cartilage

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

See PGF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PGF

SOURCE GeneReport for Unigene cluster: Hs.252820

UniProtKB/Swiss-Prot: PLGF_HUMAN, P49763

Tissue specificity: While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8

week) placenta and only PlGF-1 is found in the colon and mammary carcinomas

SABiosciences Expression via Pathway-Focused PCR Arrays including PGF (see all 7):

Growth Factors in human mouse rat

Endothelial Cell Biology in human mouse rat

Angiogenic Growth Factors in human mouse rat

Cancer PathwayFinder in human mouse rat

VEGF Signaling in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PGF gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC771832¹	placenta growth factor-like	71.17(n) 55.86(a)		771832 XM_001235058.2 XP_001235059.2
zebrafish (Danio rerio)	Actinopterygii	LOC557468¹	placenta growth factor-like	60.69(n) 53.1(a)		557468 XM_680548.4 XP_685640.4

ENSEMBL Gene Tree for PGF (if available)
TreeFam Gene Tree for PGF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PGF gene

VEGFC² FIGF² VEGFA² VEGFB²

3 SIMAP similar genes for PGF using alignment to 3 protein entries: PLGF_HUMAN (see all proteins):

VEGF VEGFA VEGFB

PGF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61759413^1,2	C,F,	--	55576442(-)	`TCTCCG/AAGCCT`	2	--	ds500¹		3		NS WA	210
rs113443961^1,2		--	55576470(+)	`TGTTAC/TACCCC`	2	--	ds500¹		1		CSA	2
rs61759412^1,2	C,F,	--	55576508(-)	`TGTCAG/TCCGGG`	2	--	ds500¹		3		NS WA	210
rs61759411^1,2	C,F,	--	55576676(-)	`TGTGCG/ATCCCA`	2	--	ut3¹		4		NS CSA WA	212
rs1042886^1,2	C,F,A,H,	--	55576780(-)	`CCCCCA/C/GCTAAG`	4	--	ut3¹		18		NS EA NA CSA WA	1962
rs8185^1,2	C,F,A,H,	--	55576802(-)	`CGGCCA/GAGGTG`	2	--	ut3¹		34		MN NA EA NS WA CSA	3595
rs61759410^1,2	C,	--	55576806(-)	`TTTCCG/AGCCAA`	2	--	ut3¹		3		NS WA	204
rs41304363^1,2	C,	--	55576991(+)	`AGGCCG/ATGGCG`	2	--	ut3¹		4		NA NS	98
rs201650328^1,2	C	--	55577021(-)	`CCAAAA/GTAGGG`	2	--	ut3¹		0	--	--	--	--
rs10137936^1,2	C,F,A,H,	--	55577184(+)	`TTCTTT/CCAAAG`	2	--	ut3¹		13		NS EA NA WA	1500

HapMap Linkage Disequilibrium report for PGF (75408537 - 75422487 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PGF: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGF

DNA2.0 Custom Variant and Variant Library Synthesis for PGF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PGF for disorders           About GeneDecksing

OMIM gene information: 601121    OMIM disorders: --

20/91 diseases for PGF (see all 91):    About MalaCards

severe pre-eclampsia pre-eclampsia middle ear cholesteatoma placental insufficiency

critical limb ischemia intermittent claudication myocardial infarction placental abruption

acute myocardial infarction malignant pleural mesothelioma ectopic pregnancy proliferative diabetic retinopathy

myxoid liposarcoma diabetic retinopathy sickle cell disease insulin resistance

sickle cell anemia ischemic heart disease lymphoblastic leukemia systemic lupus erythematosus

4 diseases from the University of Copenhagen DISEASES database for PGF:

Hypertension Endometritis Proteinuria Cancer

10/48 Novoseek disease relationships for PGF gene (see all 48) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
preeclampsia	86.7	255	17460385 (7), 17403407 (7), 15117604 (6), 15632339 (6) (see all 87)
neovascularization	70.1	24	12714333 (1), 16754748 (1), 19505392 (1), 15312686 (1) (see all 20)
intrauterine growth retardation	62.2	4	19536710 (1), 19996864 (1), 15591804 (1), 18058842 (1)
pregnancy complications	56.4	2	19536710 (1), 18175241 (1)
proteinuria	50.1	10	19165674 (2), 15632339 (2), 15117604 (1), 17553534 (1) (see all 5)
severe pre-eclampsia	48.8	1	15938782 (1)
sickle cell disease	39.7	3	20351105 (1), 20040765 (1), 19010294 (1)
tumors	35.1	84	12673673 (5), 19805167 (4), 16618713 (4), 7478581 (4) (see all 39)
systemic hypertension	34.2	5	17371983 (1), 15663401 (1), 16711023 (1), 18648513 (1) (see all 5)
inflammation	33.6	29	16412852 (3), 18411415 (2), 17157858 (2), 19010294 (2) (see all 19)

Human Genome Epidemiology (HuGE) Navigator: PGF (3 documents)

Export disorders for PGF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PGF gene, integrated from 9 sources (see all 445):
(articles sorted by number of sources associating them with PGF)

Utopia: connect your pdf to the dynamic
world of online information

Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14. (PubMed id 7681160)^{1, 2, 3, 9} Maglione D.... Persico M.G. (1993)
A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. (PubMed id 8148155)^{1, 2, 9} Hauser S.D. and Weich H.A. (1993)
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. (PubMed id 1924389)^{1, 2, 9} Maglione D.... Persico M.G. (1991)
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF . (PubMed id 21215706)^{1, 2} Rolny C....Carmeliet P. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{1, 2} Heilig R.... Weissenbach J. (2003)
The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution. (PubMed id 11069911)^{1, 2} Iyer S.... Acharya K.R. (2001)
Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing. (PubMed id 9207183)^{1, 2} Cao Y.... Cao Y. (1997)
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. (PubMed id 7929268)^{1, 2} Park J.E.... Ferrara N. (1994)
Serum sFlt1:PlGF ratio, PlGF, and soluble endoglin levels in gestational proteinuria. (PubMed id 19165674)^{1, 9} Ohkuchi A....Suzuki M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5228	HGNC: 8893	AceView: PGF	Ensembl:ENSG00000119630	euGenes: HUgn5228
ECgene: PGF	Kegg: 5228	H-InvDB: PGF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PGF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PGF	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PGF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PGF gene:
Search GeneIP for patents involving PGF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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