Aliases for PGF Gene
External Ids for PGF Gene
Previous HGNC Symbols for PGF Gene
Previous GeneCards Identifiers for PGF Gene
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
GeneCards Summary for PGF Gene
PGF (Placental Growth Factor) is a Protein Coding gene. Diseases associated with PGF include Placental Insufficiency and Twin-To-Twin Transfusion Syndrome. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is VEGFB.
UniProtKB/Swiss-Prot for PGF Gene
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.