External Ids for PGD Gene
Previous GeneCards Identifiers for PGD Gene
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
GeneCards Summary for PGD Gene
PGD (Phosphogluconate Dehydrogenase) is a Protein Coding gene. Diseases associated with PGD include 6-phosphogluconate dehydrogenase deficiency and glucosephosphate dehydrogenase deficiency. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include NADP binding and phosphogluconate dehydrogenase (decarboxylating) activity.
UniProtKB/Swiss-Prot for PGD Gene
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.