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Aliases for PGD Gene

Aliases for PGD Gene

  • Phosphogluconate Dehydrogenase 2 3
  • EC 1.1.1.44 4 63
  • 6-Phosphogluconate Dehydrogenase, Decarboxylating 3
  • PGDH 4
  • 6PGD 3

External Ids for PGD Gene

Previous GeneCards Identifiers for PGD Gene

  • GC01P010420
  • GC01P010302
  • GC01P010068
  • GC01P010168
  • GC01P010393
  • GC01P009613
  • GC01P010458

Summaries for PGD Gene

Entrez Gene Summary for PGD Gene

  • 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

GeneCards Summary for PGD Gene

PGD (Phosphogluconate Dehydrogenase) is a Protein Coding gene. Diseases associated with PGD include 6-phosphogluconate dehydrogenase deficiency and trypanosomiasis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADP binding and phosphogluconate dehydrogenase (decarboxylating) activity.

UniProtKB/Swiss-Prot for PGD Gene

  • Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGD Gene

Genomics for PGD Gene

Regulatory Elements for PGD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PGD Gene

Start:
10,398,592 bp from pter
End:
10,420,144 bp from pter
Size:
21,553 bases
Orientation:
Plus strand

Genomic View for PGD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGD Gene

Proteins for PGD Gene

  • Protein details for PGD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52209-6PGD_HUMAN
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    Protein Accession:
    P52209
    Secondary Accessions:
    • A8K2Y9
    • B4DQJ8
    • Q9BWD8

    Protein attributes for PGD Gene

    Size:
    483 amino acids
    Molecular mass:
    53140 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PGD Gene

    Alternative splice isoforms for PGD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGD Gene

Proteomics data for PGD Gene at MOPED

Post-translational modifications for PGD Gene

  • Ubiquitination at Lys38, Lys59, Lys119, Lys163, Lys265, and Lys377
  • Modification sites at PhosphoSitePlus

Other Protein References for PGD Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PGD (PGD)

Domains for PGD Gene

Graphical View of Domain Structure for InterPro Entry

P52209

UniProtKB/Swiss-Prot:

6PGD_HUMAN :
  • P52209
Family:
  • Belongs to the 6-phosphogluconate dehydrogenase family.
genes like me logo Genes that share domains with PGD: view

No data available for Gene Families for PGD Gene

Function for PGD Gene

Molecular function for PGD Gene

GENATLAS Biochemistry: phosphogluconate dehydrogenase,pentose phosphate pathway
UniProtKB/Swiss-Prot CatalyticActivity: 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH
UniProtKB/Swiss-Prot Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.

Enzyme Numbers (IUBMB) for PGD Gene

Gene Ontology (GO) - Molecular Function for PGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity ISS --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with PGD: view
genes like me logo Genes that share phenotypes with PGD: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGD

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PGD Gene

Localization for PGD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGD Gene COMPARTMENTS Subcellular localization image for PGD gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PGD: view

Pathways for PGD Gene

genes like me logo Genes that share pathways with PGD: view

UniProtKB/Swiss-Prot P52209-6PGD_HUMAN

  • Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3

Gene Ontology (GO) - Biological Process for PGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006098 pentose-phosphate shunt TAS --
GO:0009051 pentose-phosphate shunt, oxidative branch IDA 3858849
GO:0019322 pentose biosynthetic process IEA --
GO:0019521 D-gluconate metabolic process IEA --
genes like me logo Genes that share ontologies with PGD: view

Compounds for PGD Gene

(8) HMDB Compounds for PGD Gene

Compound Synonyms Cas Number PubMed IDs
6-Phosphogluconic acid
  • 6-Phospho-D-gluconate
921-62-0
Angiotensin II
  • Hypertensin
11128-99-7
Carbon dioxide
  • Carbon oxide
124-38-9
D-Ribulose 5-phosphate
  • D-Ribulose 5-phosphate
4151-19-3
Manganese
  • manganese
7439-96-5

(10) Drugbank Compounds for PGD Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
6-Phosphogluconic Acid
target
Dacarbazine
  • Biocarbazine R
4342-03-4 target inhibitor
Furosemide
  • Dihydroflumethiazide
54-31-9 enzyme inhibitor
Gadopentetate dimeglumine
86050-77-3 target inhibitor
Ketotifen
  • Ketotifen Fumarate
34580-14-8 target inhibitor

(42) Novoseek inferred chemical compound relationships for PGD Gene

Compound -log(P) Hits PubMed IDs
6-phosphogluconate 98.6 139
glucose 6-phosphate 87.8 72
6-phosphogluconolactone 80 1
ribulose 5-phosphate 73.2 3
6-aminonicotinamide 70.5 3
genes like me logo Genes that share compounds with PGD: view

Transcripts for PGD Gene

Unigene Clusters for PGD Gene

Phosphogluconate dehydrogenase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGD

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGD Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8: -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - -
SP12:
SP13:

ExUns: 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13: -

Relevant External Links for PGD Gene

GeneLoc Exon Structure for
PGD
ECgene alternative splicing isoforms for
PGD

Expression for PGD Gene

mRNA expression in normal human tissues for PGD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGD Gene

This gene is overexpressed in Whole Blood (19.2) and Esophagus - Mucosa (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGD Gene

SOURCE GeneReport for Unigene cluster for PGD Gene Hs.464071

genes like me logo Genes that share expressions with PGD: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PGD Gene

Orthologs for PGD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGD 35
  • 94.55 (n)
  • 94.01 (a)
PGD 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PGD 35
  • 88.34 (n)
  • 94.82 (a)
PGD 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGD 35
  • 88.75 (n)
  • 94.62 (a)
PGD 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgd 35
  • 87.85 (n)
  • 94 (a)
Pgd 16
Pgd 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PGD 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGD 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360180 35
  • 86.75 (n)
  • 93.17 (a)
chicken
(Gallus gallus)
Aves PGD 35
  • 80.43 (n)
  • 90.04 (a)
PGD 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGD 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68486 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pgd 35
  • 74.43 (n)
  • 86.69 (a)
Str.15342 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.45 35
zebrafish
(Danio rerio)
Actinopterygii Dr.6619 35
pgd 35
  • 75.5 (n)
  • 87.58 (a)
pgd 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004197 35
  • 66.81 (n)
  • 71.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pgd 35
  • 67.15 (n)
  • 72.38 (a)
Pgd 36
  • 72 (a)
OneToOne
Pgd 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea T25B9.9 35
  • 63.62 (n)
  • 69.92 (a)
T25B9.9 36
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR129W 35
  • 63.26 (n)
  • 65.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GND1 35
  • 62.35 (n)
  • 66.81 (a)
GND1 36
  • 65 (a)
OneToMany
GND1 38
GND2 36
  • 64 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09339g 35
  • 63.38 (n)
  • 67.92 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6832 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G41670 35
  • 53.43 (n)
  • 52.15 (a)
rice
(Oryza sativa)
Liliopsida Os11g0484500 35
  • 55.44 (n)
  • 51.62 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03100 35
  • 65.97 (n)
  • 67.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC660.16 35
  • 61.31 (n)
  • 67.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13189 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 76 (a)
OneToOne
Species with no ortholog for PGD:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGD Gene

ENSEMBL:
Gene Tree for PGD (if available)
TreeFam:
Gene Tree for PGD (if available)

Paralogs for PGD Gene

Pseudogenes.org Pseudogenes for PGD Gene

genes like me logo Genes that share paralogs with PGD: view

No data available for Paralogs for PGD Gene

Variants for PGD Gene

Sequence variations from dbSNP and Humsavar for PGD Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs505445 -- 10,402,027(-) taatt(A/T)attta intron-variant
rs1049887 -- 10,400,428(+) GTTGA(C/T)GATTT synonymous-codon, reference
rs1134021 -- 10,420,210(+) AGAAA(A/G)ATTTT downstream-variant-500B
rs1134024 -- 10,420,313(+) TTTAA(A/T)ACCCT downstream-variant-500B
rs1134026 -- 10,420,425(+) GGCAA(A/G)CTGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PGD Gene

Variant ID Type Subtype PubMed ID
dgv17e1 CNV Complex 17122850
essv3548 CNV CNV 17122850
nsv8213 CNV Gain 18304495
esv1010529 CNV Deletion 20482838

Relevant External Links for PGD Gene

HapMap Linkage Disequilibrium report
PGD
Human Gene Mutation Database (HGMD)
PGD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGD Gene

Disorders for PGD Gene

(1) University of Copenhagen DISEASES for PGD Gene

(8) Novoseek inferred disease relationships for PGD Gene

Disease -log(P) Hits PubMed IDs
enzymopathy 65.5 1
leishmaniasis cutaneous 57.6 1
g6pd deficiency 43.2 2
trypanosomiasis african 38.2 1
leishmaniasis visceral 13.2 1

Relevant External Links for PGD

Genetic Association Database (GAD)
PGD
Human Genome Epidemiology (HuGE) Navigator
PGD
genes like me logo Genes that share disorders with PGD: view

No data available for UniProtKB/Swiss-Prot for PGD Gene

Publications for PGD Gene

  1. Identification of a cDNA encoding 6-phosphogluconate dehydrogenase from a human heart cDNA library. (PMID: 8978909) Tsui S.K.W. … Lee C.-Y. (Biochem. Genet. 1996) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. (PMID: 20676096) Zhang H. … Zhou G. (Nat. Genet. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. 6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species. (PMID: 9920387) Rippa M. … Hanau S. (Biochim. Biophys. Acta 1998) 3 23

Products for PGD Gene

Sources for PGD Gene

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