Aliases for PGAP1 Gene
External Ids for PGAP1 Gene
Previous GeneCards Identifiers for PGAP1 Gene
PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PGAP1 Gene
PGAP1 (Post-GPI Attachment To Proteins 1) is a Protein Coding gene. Diseases associated with PGAP1 include autosomal recessive spastic paraplegia type 67 and mental retardation, autosomal recessive 42. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include hydrolase activity, acting on ester bonds and phosphoric ester hydrolase activity.
UniProtKB/Swiss-Prot for PGAP1 Gene
Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity).