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Aliases for PGAM5 Gene

Aliases for PGAM5 Gene

  • PGAM Family Member 5, Serine/Threonine Protein Phosphatase, Mitochondrial 2 3
  • Phosphoglycerate Mutase Family Member 5 2 3 4
  • Bcl-XL-Binding Protein V68 3 4
  • EC 3.1.3.16 4
  • BXLBV68 3

External Ids for PGAM5 Gene

Previous GeneCards Identifiers for PGAM5 Gene

  • GC12P131797
  • GC12P133265
  • GC12P133287

Summaries for PGAM5 Gene

GeneCards Summary for PGAM5 Gene

PGAM5 (PGAM Family Member 5, Serine/Threonine Protein Phosphatase, Mitochondrial) is a Protein Coding gene. Among its related pathways are TNF signaling pathway. GO annotations related to this gene include GTPase activator activity and phosphatase activity.

UniProtKB/Swiss-Prot for PGAM5 Gene

  • Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGAM5 Gene

Genomics for PGAM5 Gene

Regulatory Elements for PGAM5 Gene

Genomic Location for PGAM5 Gene

Chromosome:
12
Start:
132,710,807 bp from pter
End:
132,722,737 bp from pter
Size:
11,931 bases
Orientation:
Plus strand

Genomic View for PGAM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGAM5 Gene

Proteins for PGAM5 Gene

  • Protein details for PGAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HS1-PGAM5_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PGAM5, mitochondrial
    Protein Accession:
    Q96HS1
    Secondary Accessions:
    • A9LN06
    • C9IZY7
    • Q96JB0

    Protein attributes for PGAM5 Gene

    Size:
    289 amino acids
    Molecular mass:
    32004 Da
    Quaternary structure:
    • Dimer. Forms a ternary complex with NFE2L2 and KEAP1. Interacts with BCL2L1 and MAP3K5. Upon TNF-induced necrosis, forms in complex with RIPK1, RIPK3 and MLKL; the formation of this complex leads to PGAM5 phosphorylation. Isoform 2, but not isoform 1, interacts with DNM1L; this interaction leads to DNM1L dephosphorylation and activation and eventually to mitochondria fragmentation.

    Three dimensional structures from OCA and Proteopedia for PGAM5 Gene

    Alternative splice isoforms for PGAM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGAM5 Gene

Proteomics data for PGAM5 Gene at MOPED

Post-translational modifications for PGAM5 Gene

  • Both isoform 1 and isoform 2 are phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity
  • Ubiquitination at Lys 88 and Lys 141
  • Modification sites at PhosphoSitePlus

Other Protein References for PGAM5 Gene

No data available for DME Specific Peptides for PGAM5 Gene

Domains & Families for PGAM5 Gene

Gene Families for PGAM5 Gene

Protein Domains for PGAM5 Gene

Suggested Antigen Peptide Sequences for PGAM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HS1

UniProtKB/Swiss-Prot:

PGAM5_HUMAN :
  • The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane.
  • Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Domain:
  • The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane.
Family:
  • Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
genes like me logo Genes that share domains with PGAM5: view

Function for PGAM5 Gene

Molecular function for PGAM5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.

Enzyme Numbers (IUBMB) for PGAM5 Gene

Gene Ontology (GO) - Molecular Function for PGAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 22265414
GO:0009400 receptor signaling protein serine/threonine phosphatase activity IDA 19590015
GO:0016791 phosphatase activity IMP 22265414
GO:0032403 protein complex binding IDA 22265414
genes like me logo Genes that share ontologies with PGAM5: view

Phenotypes for PGAM5 Gene

genes like me logo Genes that share phenotypes with PGAM5: view

Animal Model Products

miRNA for PGAM5 Gene

miRTarBase miRNAs that target PGAM5

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PGAM5 Gene

Localization for PGAM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGAM5 Gene

Mitochondrion outer membrane; Single-pass membrane protein. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGAM5 Gene COMPARTMENTS Subcellular localization image for PGAM5 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for PGAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PGAM5: view

Pathways & Interactions for PGAM5 Gene

SuperPathways for PGAM5 Gene

Superpath Contained pathways
1 TNF signaling pathway
genes like me logo Genes that share pathways with PGAM5: view

Pathways by source for PGAM5 Gene

1 KEGG pathway for PGAM5 Gene

Gene Ontology (GO) - Biological Process for PGAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IMP 22265414
GO:0035556 intracellular signal transduction IDA 19590015
GO:0043547 positive regulation of GTPase activity IMP 22265414
GO:0070266 necroptotic process IMP 22265414
genes like me logo Genes that share ontologies with PGAM5: view

No data available for SIGNOR curated interactions for PGAM5 Gene

Drugs & Compounds for PGAM5 Gene

(1) Drugs for PGAM5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-Phosphoglyceric acid Experimental Pharma 0

(2) Additional Compounds for PGAM5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PGAM5: view

Transcripts for PGAM5 Gene

Unigene Clusters for PGAM5 Gene

Phosphoglycerate mutase family member 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGAM5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGAM5 Gene

No ASD Table

Relevant External Links for PGAM5 Gene

GeneLoc Exon Structure for
PGAM5
ECgene alternative splicing isoforms for
PGAM5

Expression for PGAM5 Gene

mRNA expression in normal human tissues for PGAM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGAM5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0) and Adrenal (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGAM5 Gene



SOURCE GeneReport for Unigene cluster for PGAM5 Gene Hs.102558

genes like me logo Genes that share expression patterns with PGAM5: view

Protein tissue co-expression partners for PGAM5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PGAM5 Gene

Orthologs for PGAM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGAM5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGAM5 35
  • 87.62 (n)
  • 93.06 (a)
PGAM5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGAM5 35
  • 88.08 (n)
  • 93.06 (a)
PGAM5 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgam5 35
  • 84.79 (n)
  • 93.73 (a)
Pgam5 16
Pgam5 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGAM5 35
  • 99.58 (n)
  • 100 (a)
PGAM5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgam5 35
  • 84.67 (n)
  • 93.03 (a)
oppossum
(Monodelphis domestica)
Mammalia PGAM5 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGAM5 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGAM5 35
  • 74.17 (n)
  • 81.67 (a)
PGAM5 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGAM5 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pgam5 35
  • 65.71 (n)
  • 66.55 (a)
Str.1334 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398484 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24263 35
pgam5 35
  • 64.4 (n)
  • 67.5 (a)
pgam5 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10049 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002535 35
  • 54.97 (n)
  • 48.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pgam5 35
  • 55.14 (n)
  • 46.99 (a)
Pgam5 36
  • 43 (a)
OneToMany
Pgam5-2 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pgam-5 35
  • 55.31 (n)
  • 53.54 (a)
pgam-5 36
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
CSA.3656 36
  • 47 (a)
OneToMany
Species with no ortholog for PGAM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGAM5 Gene

ENSEMBL:
Gene Tree for PGAM5 (if available)
TreeFam:
Gene Tree for PGAM5 (if available)

Paralogs for PGAM5 Gene

Pseudogenes.org Pseudogenes for PGAM5 Gene

genes like me logo Genes that share paralogs with PGAM5: view

No data available for Paralogs for PGAM5 Gene

Variants for PGAM5 Gene

Sequence variations from dbSNP and Humsavar for PGAM5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1142465 -- 132,722,416(+) tggct(A/G)atttt utr-variant-3-prime
rs4883606 -- 132,722,187(-) TGAGC(C/T)GTCAA utr-variant-3-prime
rs4883607 -- 132,716,698(-) CTGCA(C/T)TTCCT intron-variant
rs4883608 -- 132,716,618(-) CTGGA(C/T)GCTGT intron-variant
rs4883609 -- 132,716,465(-) GATTA(C/T)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGAM5 Gene

Variant ID Type Subtype PubMed ID
dgv1534n71 CNV Loss 21882294
nsv899827 CNV Gain 21882294

Variation tolerance for PGAM5 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGAM5 Gene

HapMap Linkage Disequilibrium report
PGAM5
Human Gene Mutation Database (HGMD)
PGAM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGAM5 Gene

Disorders for PGAM5 Gene

Relevant External Links for PGAM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGAM5
genes like me logo Genes that share disorders with PGAM5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGAM5 Gene

Publications for PGAM5 Gene

  1. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. (PMID: 19590015) Takeda K. … Ichijo H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 2 67
  2. PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. (PMID: 18387606) Lo S.-C. … Hannink M. (Exp. Cell Res. 2008) 23 67
  3. PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. (PMID: 17046835) Lo S.-C. … Hannink M. (J. Biol. Chem. 2006) 23 67
  4. In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries. (PMID: 11283018) Hammond P.W. … Kreider B.L. (J. Biol. Chem. 2001) 2 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for PGAM5 Gene

Sources for PGAM5 Gene

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