PGAM4 Gene
protein-coding GIFtS: 49
GCID: GC0XM077223
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phosphoglycerate mutase family member 4(Previous name: phosphoglycerate mutase family 4 )
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Aliases
for PGAM4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphoglycerate Mutase Family Member 41 2 | | Phosphoglycerate Mutase 42 | | PGAM31 2 3 5 | | Phosphoglycerate Mutase Family 32 | | PGAM-B1 2 | | Phosphoglycerate Mutase Processed Protein2 | | PGAM11 2 | | Probable Phosphoglycerate Mutase 42 | | DJ1000K24.11 | | EC 3.1.3.133 | | EC 5.4.2.13 8 | | EC 5.4.2.43 | | Phosphoglycerate Mutase Family 41 | | |
Export aliases for PGAM4 gene to outside databasesPrevious GC identifers: GC0XM9L0730 GC0XM077110 GC0XM070810 |
Summaries
for PGAM4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PGAM4:
This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed,protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes thatcatalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. (provided by RefSeq, May2010)
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Genomic Views
for PGAM4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PGAM4 gene promoter:
AML1a GATA-2 E47 SRY S8 PPAR-gamma1 POU2F1 HFH-1 POU2F1a PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PGAM4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGAM4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq21.1PGAM4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM077223: view genomic region
(about GC identifiers)
Start:
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77,223,458 bp from pter |
End:
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77,225,135 bp from pter |
Size:
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1,678 bases |
Orientation:
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minus strand |
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Proteins
for PGAM4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PGAM4_HUMAN, Q8N0Y7 (See
protein sequence)Recommended Name: Probable phosphoglycerate mutase 4 Size: 254 amino acids; 28777 Da
Miscellaneous: This is the product of a processed gene created by retroposition from mRNA of an expressed gene. Thisgene seems to be expressed
Secondary accessions: Q5JPN2 Q8NI24 Q8NI25 Q8NI26Explore the universe of human proteins at neXtProt for PGAM4: NX_Q8N0Y7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N0Y7
4/6 DME Specific Peptides for PGAM4 (Q8N0Y7) (see all 6)
PGAM4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001025062.1
ENSEMBL proteins: ENSP00000412189
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
PGAM4 for ontologies About GeneDecksing
PGAM4 Antibody Products:
Assay Products for PGAM4: |
Protein
Domains /
Families
for PGAM4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PGAM4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N0Y7ProtoNet protein and cluster: Q8N0Y7 1 Blocks protein family: IPB001345 Phosphoglycerate/bisphosphoglycerate mutase
UniProtKB/Swiss-Prot: PGAM4_HUMAN, Q8N0Y7Similarity: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily |
Function
for PGAM4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PGAM4_HUMAN, Q8N0Y7Catalytic activity: 2-phospho-D-glycerate = 3-phospho-D-glycerateCatalytic activity: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerateCatalytic activity: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphateEnzyme Numbers (IUBMB): EC 5.4.2.11 2 EC 5.4.2.41 EC 3.1.3.131
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGAM4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGAM4
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Synthesis Service for PGAM4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGAM4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004082 | bisphosphoglycerate mutase activity |
IEA | -- | | GO:0004083 | bisphosphoglycerate 2-phosphatase activity |
IEA | -- | | GO:0004619 | phosphoglycerate mutase activity |
NAS | 11961099 |
PGAM4 for ontologies About GeneDecksing
|
Pathways & Interactions
for PGAM4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glycolysis and gluconeogenesis (short map) | | | 2 | gluconeogenesis I | | | 3 | Rapoport-Luebering glycolytic shunt | | | 4 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PGAM4
1  GeneGo (Thomson Reuters) Pathway for PGAM4
3  BioSystems Pathways for PGAM4
2 
Kegg Pathways (Kegg details for PGAM4):
PGAM4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PGAM4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/17 Interacting proteins for PGAM4 (Q8N0Y73 ENSP000004121894) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
PGAM4 for ontologies About GeneDecksing
|
Drugs & Compounds
for PGAM4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PGAM4
3 HMDB Compounds for PGAM4 About this table
Search CenterWatch for drugs/clinical trials and news about PGAM4
|
Transcripts
for PGAM4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PGAM4 gene: NM_001029891.2 Unigene Cluster for PGAM4: Phosphoglycerate mutase family member 4 Hs.632822 [show with all ESTs]Unigene Representative Sequence: BF5689581 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000458128(uc004ecy.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGAM4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGAM4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PGAM4 (NM_001029891) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PGAM4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGAM4 |
9 DOTS entries: DT.121298334 DT.100890671 DT.97857622 DT.100890627 DT.100890648 DT.100890656 DT.121182761 DT.91966784 DT.95252793 24 AceView cDNA sequences: AA377047 BG875904 BG875906 BQ316431 R54260 BQ317024 AI358563 AW972022 AA171562 BM848509 R58419 BG822605 BQ354166 W40426 AL568626 AL567917 AL568382 AL573068 BQ339031 T19606 R88087 BQ348979 BI086014 AW838900
GeneLoc Exon Structure
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Expression
for PGAM4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PGAM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PGAM4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.632822
SABiosciences Custom PCR Arrays for PGAM4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PGAM4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PGAM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGAM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGAM4 |
Orthologs
for PGAM4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for PGAM4 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for PGAM4 (if available)
TreeFam Gene Tree for PGAM4 (if available) |
Paralogs
for PGAM4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PGAM4 gene
- BPGM2 PGAM12 PGAM22
3 SIMAP similar genes for PGAM4 using alignment to 1 protein entry: PGAM4_HUMAN:PGAM1 PGAM2 BPGM
PGAM4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PGAM4
PGOHUM00000245664 PGOHUM00000241790
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Genomic Variants
for PGAM4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PGAM4
1 CNV: 4156
Human Gene Mutation Database (HGMD): PGAM4
Locus Specific Mutation Databases (LSDB): PGAM4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGAM4 |
|
Disorders
/ Diseases
for PGAM4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PGAM4 for disorders About GeneDecksing
OMIM gene information: 300567
OMIM disorders: --
5  diseases for PGAM4: About MalaCardsmenkes disease pneumonia tuberculosis malaria
mycobacterium tuberculosis
Export disorders for PGAM4 gene to outside databases
|
Publications
for PGAM4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PGAM4 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with PGAM4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene. (PubMed id 11961099)1, 2, 3, 9 Betran E.... Long M. (2002)
- Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
- A phosphoglycerate mutase brain isoform (PGAM 1) pseu dogene is localized within the human Menkes disease gene (ATP7 A). (PubMed id 9370262)1, 3 Dierick H.A....Glover T.W. (1997)
- A single nucleotide polymorphism within the novel sex- linked testis-specific retrotransposed PGAM4 gene influences human male fertilit y. (PubMed id 22590500)1 Okuda H....Tanaka H. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1 Kim S.C.... Zhao Y. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
- Experimental validation of metabolic pathway modeling. (PubMed id 18510554)9 Moreno-Sanchez R....Saavedra E. (2008)
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External Searches for PGAM4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PGAM4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PGAM4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PGAM4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PGAM4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PGAM4 gene:
Search GeneIP for patents involving PGAM4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PGAM4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PGAM4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PGAM4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PGAM4 | | | OriGene Protein Over-expression Lysate for PGAM4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PGAM4 | | OriGene 3'-UTR Clone for PGAM4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PGAM4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PGAM4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PGAM4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGAM4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGAM4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGAM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGAM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGAM4 |
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 | | | PGAM4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for PGAM4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGAM4 |
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