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Aliases for PGAM4 Gene

Aliases for PGAM4 Gene

  • Phosphoglycerate Mutase Family Member 4 2 3
  • PGAM3 3 4 6
  • Phosphoglycerate Mutase Processed Protein 3
  • Probable Phosphoglycerate Mutase 4 3
  • Phosphoglycerate Mutase Family 4 2
  • Phosphoglycerate Mutase Family 3 3
  • Phosphoglycerate Mutase 4 3
  • DJ1000K24.1 3
  • EC 4
  • EC 4
  • EC 63
  • EC 4
  • PGAM-B 3
  • PGAM1 3

External Ids for PGAM4 Gene

Previous GeneCards Identifiers for PGAM4 Gene

  • GC0XM9L0730
  • GC0XM077110
  • GC0XM077223
  • GC0XM070810

Summaries for PGAM4 Gene

Entrez Gene Summary for PGAM4 Gene

  • This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed, protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. [provided by RefSeq, May 2010]

GeneCards Summary for PGAM4 Gene

PGAM4 (Phosphoglycerate Mutase Family Member 4) is a Protein Coding gene. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include bisphosphoglycerate mutase activity and phosphoglycerate mutase activity. An important paralog of this gene is PGAM1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGAM4 Gene

Genomics for PGAM4 Gene

Regulatory Elements for PGAM4 Gene

Genomic Location for PGAM4 Gene

77,967,961 bp from pter
77,969,638 bp from pter
1,678 bases
Minus strand

Genomic View for PGAM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGAM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGAM4 Gene

Proteins for PGAM4 Gene

  • Protein details for PGAM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable phosphoglycerate mutase 4
    Protein Accession:
    Secondary Accessions:
    • Q5JPN2
    • Q8NI24
    • Q8NI25
    • Q8NI26

    Protein attributes for PGAM4 Gene

    254 amino acids
    Molecular mass:
    28777 Da
    Quaternary structure:
    No Data Available
    • This is the product of a processed gene created by retroposition from mRNA of an expressed gene. This gene seems to be expressed

neXtProt entry for PGAM4 Gene

Proteomics data for PGAM4 Gene at MOPED

Selected DME Specific Peptides for PGAM4 Gene

Post-translational modifications for PGAM4 Gene

  • Ubiquitination at Lys5, Lys100, Lys106, and Lys138
  • Modification sites at PhosphoSitePlus

Other Protein References for PGAM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PGAM4 Gene

Gene Families for PGAM4 Gene

Suggested Antigen Peptide Sequences for PGAM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
  • Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
genes like me logo Genes that share domains with PGAM4: view

Function for PGAM4 Gene

Molecular function for PGAM4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-phospho-D-glycerate = 3-phospho-D-glycerate
UniProtKB/Swiss-Prot CatalyticActivity:
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate
UniProtKB/Swiss-Prot CatalyticActivity:
2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate

Enzyme Numbers (IUBMB) for PGAM4 Gene

Gene Ontology (GO) - Molecular Function for PGAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004082 bisphosphoglycerate mutase activity IEA --
GO:0004083 bisphosphoglycerate 2-phosphatase activity IEA --
GO:0004619 phosphoglycerate mutase activity NAS 11961099
GO:0016868 intramolecular transferase activity, phosphotransferases --
genes like me logo Genes that share ontologies with PGAM4: view

Animal Model Products

CRISPR Products

miRNA for PGAM4 Gene

miRTarBase miRNAs that target PGAM4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGAM4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for PGAM4 Gene

Localization for PGAM4 Gene

Subcellular locations from

Jensen Localization Image for PGAM4 Gene COMPARTMENTS Subcellular localization image for PGAM4 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PGAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
GO:0097228 sperm principal piece IDA 22590500
genes like me logo Genes that share ontologies with PGAM4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PGAM4 Gene

Pathways for PGAM4 Gene

genes like me logo Genes that share pathways with PGAM4: view

Interacting Proteins for PGAM4 Gene

Gene Ontology (GO) - Biological Process for PGAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006096 glycolytic process NAS 11961099
GO:0016311 dephosphorylation IEA --
GO:1902093 positive regulation of sperm motility NAS 22590500
genes like me logo Genes that share ontologies with PGAM4: view

Drugs for PGAM4 Gene

(7) HMDB Compounds for PGAM4 Gene

Compound Synonyms Cas Number PubMed IDs
2,3-Diphosphoglyceric acid
  • (2R)-2,3-bis(phosphonooxy)-Propanoate
2-Phospho-D-glyceric acid
  • (2R)-3-hydroxy-2-(phosphonooxy)propanoate
2-Phosphoglyceric acid
  • 2-(Dihydrogen phosphate)Glycerate
3-Phosphoglyceric acid
  • 3-(Dihydrogen phosphate)Glycerate
Glyceric acid 1,3-biphosphate
  • 1,3-Biphosphoglycerate
genes like me logo Genes that share compounds with PGAM4: view

Transcripts for PGAM4 Gene

mRNA/cDNA for PGAM4 Gene

(24) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGAM4 Gene

Phosphoglycerate mutase family member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGAM4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGAM4 Gene

No ASD Table

Relevant External Links for PGAM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGAM4 Gene

mRNA expression in normal human tissues for PGAM4 Gene

Protein differential expression in normal tissues for PGAM4 Gene

This gene is overexpressed in Lung (34.4), Lavage (12.2), and Brain (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGAM4 Gene

SOURCE GeneReport for Unigene cluster for PGAM4 Gene Hs.632822

genes like me logo Genes that share expressions with PGAM4: view

Expression partners for PGAM4 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PGAM4 Gene

Orthologs for PGAM4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGAM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGAM4 35
  • 99.34 (n)
  • 99.21 (a)
(Bos Taurus)
Mammalia PGAM1 36
  • 96 (a)
(Canis familiaris)
Mammalia PGAM4 36
  • 95 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Mus musculus)
Mammalia Pgam1 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
(Gallus gallus)
Aves PGAM1 36
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
(Danio rerio)
Actinopterygii pgam1a 36
  • 87 (a)
pgam1b 36
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pglym78 36
  • 65 (a)
Pglym87 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPM1 36
  • 49 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpm1 35
  • 55.09 (n)
  • 49.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4977 36
  • 60 (a)
Species with no ortholog for PGAM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGAM4 Gene

Gene Tree for PGAM4 (if available)
Gene Tree for PGAM4 (if available)

Paralogs for PGAM4 Gene

Paralogs for PGAM4 Gene

(3) SIMAP similar genes for PGAM4 Gene using alignment to 1 proteins: Pseudogenes for PGAM4 Gene

genes like me logo Genes that share paralogs with PGAM4: view

Variants for PGAM4 Gene

Sequence variations from dbSNP and Humsavar for PGAM4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_014355 -
VAR_014356 -
VAR_014357 -

Structural Variations from Database of Genomic Variants (DGV) for PGAM4 Gene

Variant ID Type Subtype PubMed ID
dgv2453e1 CNV Complex 17122850

Relevant External Links for PGAM4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGAM4 Gene

Disorders for PGAM4 Gene

No disorders were found for PGAM4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PGAM4 Gene

Publications for PGAM4 Gene

  1. Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene. (PMID: 11961099) Betran E. … Long M. (Mol. Biol. Evol. 2002) 2 3 4 23
  2. A phosphoglycerate mutase brain isoform (PGAM 1) pseudogene is localized within the human Menkes disease gene (ATP7 A). (PMID: 9370262) Dierick H.A. … Glover T.W. (Gene 1997) 2 3
  3. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3 4
  4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PMID: 16916647) Kim S.C. … Zhao Y. (Mol. Cell 2006) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for PGAM4 Gene

Sources for PGAM4 Gene

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