Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGAM4 Gene

protein-coding   GIFtS: 51
GCID: GC0XM077223

Phosphoglycerate Mutase Family Member 4

(Previous name: phosphoglycerate mutase family 4)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphoglycerate Mutase Family Member 41 2     Phosphoglycerate Mutase 42
PGAM32 3 5     Phosphoglycerate Mutase Family 32
EC 5.4.2.13 8     Phosphoglycerate Mutase Processed Protein2
Phosphoglycerate Mutase Family 41     Probable Phosphoglycerate Mutase 42
PGAM-B2     EC 3.1.3.133
PGAM12     EC 5.4.2.43
dJ1000K24.12     

External Ids:    HGNC: 217311   Entrez Gene: 4415312   Ensembl: ENSG000002267847   OMIM: 3005675   UniProtKB: Q8N0Y73   

Export aliases for PGAM4 gene to outside databases

Previous GC identifers: GC0XM9L0730 GC0XM077110 GC0XM070810


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGAM4 Gene:
This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed,
protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that
catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. (provided by RefSeq,
May 2010)

GeneCards Summary for PGAM4 Gene: 
PGAM4 (phosphoglycerate mutase family member 4) is a protein-coding gene. Diseases associated with PGAM4 include menkes disease, and pneumonia, and among its related super-pathways are Glycolysis and gluconeogenesis (short map) and Biosynthesis of amino acids. GO annotations related to this gene include phosphoglycerate mutase activity and bisphosphoglycerate mutase activity. An important paralog of this gene is BPGM.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGAM4 gene promoter:
         AML1a   GATA-2   E47   SRY   S8   PPAR-gamma1   POU2F1   HFH-1   POU2F1a   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PGAM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGAM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

PGAM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGAM4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM077223:  view genomic region     (about GC identifiers)

Start:
77,223,458 bp from pter      End:
77,225,135 bp from pter
Size:
1,678 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGAM4_HUMAN, Q8N0Y7 (See protein sequence)
Recommended Name: Probable phosphoglycerate mutase 4  
Size: 254 amino acids; 28777 Da
Miscellaneous: This is the product of a processed gene created by retroposition from mRNA of an expressed gene.
This gene seems to be expressed
Secondary accessions: Q5JPN2 Q8NI24 Q8NI25 Q8NI26

Explore the universe of human proteins at neXtProt for PGAM4: NX_Q8N0Y7

Explore proteomics data for PGAM4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N0Y7

  • 4/6 DME Specific Peptides for PGAM4 (Q8N0Y7) (see all 6)
     LVLIRHG  WRRSYDV  LNERHYG  IWRRSYD 

    PGAM4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PGAM4 Protein Expression
    REFSEQ proteins: NP_001025062.1  
    ENSEMBL proteins: 
     ENSP00000412189  

    Human Recombinant Protein Products for PGAM4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PGAM4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PGAM4
    GenScript Custom Purified and Recombinant Proteins Services for PGAM4
    Novus Biologicals PGAM4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PGAM4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    PGAM4 for ontologies           About GeneDecksing



    PGAM4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PGAM4
    GenScript Custom Superior Antibodies Services for PGAM4
    Search for Antibodies for PGAM4 at Abcam
    Cloud-Clone Corp. Antibodies for PGAM4 
    Search ThermoFisher Antibodies for PGAM4
    LSBio Antibodies in human, mouse, rat for PGAM4 

    Assay Products for PGAM4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PGAM4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PGAM4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PGAM4 
    Cloud-Clone Corp. CLIAs for PGAM4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001345 PG/BPGM_mutase_AS
     IPR005952 Phosphogly_mut1
     IPR013078 His_Pase_superF_clade-1

    Graphical View of Domain Structure for InterPro Entry Q8N0Y7

    ProtoNet protein and cluster: Q8N0Y7

    1 Blocks protein domain: IPB001345 Phosphoglycerate/bisphosphoglycerate mutase

    UniProtKB/Swiss-Prot: PGAM4_HUMAN, Q8N0Y7
    Similarity: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily


    PGAM4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGAM4_HUMAN, Q8N0Y7
    Catalytic activity: 2-phospho-D-glycerate = 3-phospho-D-glycerate
    Catalytic activity: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate
    Catalytic activity: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate

         Enzyme Numbers (IUBMB): EC 5.4.2.11 2 EC 5.4.2.41 EC 3.1.3.131

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004082bisphosphoglycerate mutase activity IEA--
    GO:0004083bisphosphoglycerate 2-phosphatase activity IEA--
    GO:0004619phosphoglycerate mutase activity NAS11961099
    GO:0016868intramolecular transferase activity, phosphotransferases ----
         
    PGAM4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PGAM4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PGAM4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PGAM4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PGAM4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGAM4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PGAM4:
    hsa-miR-483-3p
    SwitchGear 3'UTR luciferase reporter plasmidPGAM4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PGAM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGAM4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PGAM4
    Sirion Biotech Customized adenovirus for overexpression of PGAM4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PGAM4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PGAM4 (NM_001029891)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGAM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGAM4
    Sirion Biotech Customized lentivirus for stable overexpression of PGAM4 
                         Customized lentivirus expression plasmids for stable overexpression of PGAM4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PGAM4
    Search LifeMap BioReagents cell lines for PGAM4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGAM4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PGAM4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and gluconeogenesis (short map)0.60
    Glycolysis / Gluconeogenesis0.46
    glycolysis0.50
    gluconeogenesis0.39
    Conversion of glucose to acetyl CoA and entry into the TCA cycle0.46
    2Carbon metabolism
    Carbon metabolism0.37
    Biosynthesis of amino acids0.37
    3Metabolism
    Metabolic pathways0.40
    4Rapoport-Luebering glycolytic shunt
    Rapoport-Luebering glycolytic shunt
    5Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PGAM4
        Glycolysis and gluconeogenesis (short map)


    1 GeneGo (Thomson Reuters) Pathway for PGAM4
        Glycolysis and gluconeogenesis (short map)

    4 BioSystems Pathways for PGAM4
        Rapoport-Luebering glycolytic shunt
    gluconeogenesis
    glycolysis
    Conversion of glucose to acetyl CoA and entry into the TCA cycle


    5         Kegg Pathways  (Kegg details for PGAM4):
        Glycolysis / Gluconeogenesis
    Glycine, serine and threonine metabolism
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids


    PGAM4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PGAM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/17 Interacting proteins for PGAM4 (Q8N0Y73 ENSP000004121894) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131533I2D: score=1 
    TRAF2Q129333I2D: score=1 
    BPGMENSP000003420324STRING: ENSP00000342032
    ENO2ENSP000002292774STRING: ENSP00000229277
    ENO3ENSP000003241054STRING: ENSP00000324105
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006096glycolysis NAS11961099

    PGAM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGAM4

    3 HMDB Compounds for PGAM4    About this table
    CompoundSynonyms CAS #PubMed Ids
    2,3-Diphosphoglyceric acid(2R)-2,3-bis(phosphonooxy)-Propanoic acid (see all 20)138-81-8--
    2-Phospho-D-glyceric acid2-Phospho-D-glycerate (see all 7)----
    2-Phosphoglyceric acid2-(dihydrogen phosphate)Glycerate (see all 16)2553-59-5--

    Search CenterWatch for drugs/clinical trials and news about PGAM4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PGAM4 gene: 
    NM_001029891.2  

    Unigene Cluster for PGAM4:

    Phosphoglycerate mutase family member 4
    Hs.632822  [show with all ESTs]
    Unigene Representative Sequence: BF568958
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000458128(uc004ecy.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGAM4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PGAM4:
    hsa-miR-483-3p
    SwitchGear 3'UTR luciferase reporter plasmidPGAM4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PGAM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGAM4
    Clone
    Products:
         
    OriGene clones in human, mouse for PGAM4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PGAM4 (NM_001029891)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGAM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGAM4
    Sirion Biotech Customized lentivirus for stable overexpression of PGAM4 
                         Customized lentivirus expression plasmids for stable overexpression of PGAM4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PGAM4
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PGAM4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGAM4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGAM4

    9 DOTS entries:

    DT.121298334  DT.100890671  DT.97857622  DT.100890627  DT.100890648  DT.100890656  DT.121182761  DT.91966784 
    DT.95252793 

    24 AceView cDNA sequences:

    BG875904 AA377047 BG875906 R54260 AI358563 BQ317024 BQ316431 AW972022 
    BM848509 AA171562 R58419 BQ354166 W40426 BG822605 AL568626 AL567917 
    AL568382 AL573068 BQ348979 T19606 BQ339031 R88087 AW838900 BI086014 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGAM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PGAM4 Expression
    About this image


    See PGAM4 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.632822
        SABiosciences Custom PCR Arrays for PGAM4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PGAM4
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PGAM4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGAM4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGAM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGAM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PGAM4 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PGAM16
    Phosphoglycerate mutase 1
    90(a)
    1 → many
    6(21893888-21895347)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    1 → many
    GL343810.1(92914-98909)
    zebrafish
    (Danio rerio)
    Actinopterygii pgam1b6
    pgam1a6
    phosphoglycerate mutase 1a
    87(a)
    87(a)
    many ↔ many
    many ↔ many
    1(55247077-55258273)
    13(31616794-31621589)
    fruit fly
    (Drosophila melanogaster)
    Insecta Pglym786
    Pglym876
    Pglym87
    65(a)
    52(a)
    many ↔ many
    many ↔ many
    3R(24973970-24975623)
    3R(8057367-8058451)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPM16
    Tetrameric phosphoglycerate mutase, mediates the c...
    49(a)
    1 → many
    XI(163642-164385)
            Species with no ortholog for PGAM4

    ENSEMBL Gene Tree for PGAM4 (if available)
    TreeFam Gene Tree for PGAM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGAM4 gene
    BPGM2  PGAM12  PGAM22  
    3 SIMAP similar genes for PGAM4 using alignment to 1 protein entry:     PGAM4_HUMAN:
    PGAM1    PGAM2    BPGM

    PGAM4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PGAM4
    PGOHUM00000245664 PGOHUM00000241790


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 SNPs in PGAM4 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0143564
    ----see VAR_0143562 R Q mis40--------
    VAR_0143574
    ----see VAR_0143572 I T mis40--------
    VAR_0143554
    ----see VAR_0143552 R C mis40--------

    HapMap Linkage Disequilibrium report for PGAM4 (77223458 - 77225135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PGAM4:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2453e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): PGAM4

    Locus Specific Mutation Databases (LSDB): PGAM4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PGAM4
    DNA2.0 Custom Variant and Variant Library Synthesis for PGAM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300567    OMIM disorders: --

    3 diseases for PGAM4:    About MalaCards
    menkes disease    pneumonia    tuberculosis


    PGAM4 for disorders           About GeneDecksing


    Export disorders for PGAM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGAM4 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with PGAM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene. (PubMed id 11961099)1, 2, 3, 9 Betran E.... Long M. (2002)
    2. Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
    3. A phosphoglycerate mutase brain isoform (PGAM 1) pseu dogene is localized within the human Menkes disease gene (ATP7 A). (PubMed id 9370262)1, 3 Dierick H.A....Glover T.W. (1997)
    4. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. A single nucleotide polymorphism within the novel sex- linked testis-specific retrotransposed PGAM4 gene influences human male fertilit y. (PubMed id 22590500)1 Okuda H....Tanaka H. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 441531 HGNC: 21731 AceView: LOC441531 Ensembl:ENSG00000226784 euGenes: HUgn441531
    ECgene: PGAM4 Kegg: 441531 H-InvDB: PGAM4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGAM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PGAM4 gene:
    Search GeneIP for patents involving PGAM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PGAM4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PGAM4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PGAM4  
     OriGene qSTAR qPCR primer pairs in human, mouse for PGAM4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PGAM4   OriGene Custom Protein Services for PGAM4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PGAM4
     QIAGEN SeqTarget long-range PCR primers for resequencing PGAM4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGAM4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGAM4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGAM4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGAM4
     GenScript Custom Purified and Recombinant Proteins Services for PGAM4 GenScript cDNA clones with any tag delivered in your preferred vector for PGAM4
     GenScript Custom Assay Services for PGAM4 GenScript Custom Superior Antibodies Services for PGAM4
     GenScript Custom overexpressing Cell Line Services for PGAM4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PGAM4 promoter
     Search Chromatin IP Primers for PGAM4
     RT2 qPCR Primer Assay in human, mouse / rat PGAM4
     Search GNC Networks for PGAM4
     SABiosciences Custom PCR Arrays for PGAM4
     Search Tocris compounds for PGAM4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PGAM4 proteins
     Search for Antibodies for PGAM4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PGAM4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PGAM4
     Antibodies for PGAM4
     ELISAs for PGAM4
     CLIAs for PGAM4
     Search LifeMap BioReagents cell lines for PGAM4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGAM4
     SwitchGear 3'UTR luciferase reporter plasmids for PGAM4
     Browse SwitchGear Promoter luciferase reporter plasmids for PGAM4
     Search ThermoFisher Antibodies for PGAM4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGAM4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PGAM4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PGAM4
    Customized:
     lentivirus for stable overexpression of PGAM4
     lentivirus expression plasmids for stable overexpression of PGAM4
     adenovirus for overexpression of PGAM4
     LSBio Antibodies in human, mouse, rat for PGAM4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PGAM4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4