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Aliases for PGAM1 Gene

Aliases for PGAM1 Gene

  • Phosphoglycerate Mutase 1 (Brain) 2 3
  • Phosphoglycerate Mutase Isozyme B 3 4
  • BPG-Dependent PGAM 1 3 4
  • PGAM-B 3 4
  • PGAMA 3 4
  • Phosphoglycerate Mutase A, Nonmuscle Form 3
  • Epididymis Secretory Protein Li 35 3
  • Phosphoglycerate Mutase A 2
  • Phosphoglycerate Mutase 1 3
  • Nonmuscle Form 2
  • EC 4
  • EC 4
  • EC 63
  • EC 4
  • HEL-S-35 3

External Ids for PGAM1 Gene

Previous HGNC Symbols for PGAM1 Gene


Previous GeneCards Identifiers for PGAM1 Gene

  • GC10P098079
  • GC10P098419
  • GC10P099317
  • GC10P098850
  • GC10P099176
  • GC10P092811

Summaries for PGAM1 Gene

Entrez Gene Summary for PGAM1 Gene

  • Phosphoglyceric acid mutase (EC is widely distributed in mammalian tissues where it catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway (summary by Chen et al., 1974 [PubMed 4811757]).[supplied by OMIM, Nov 2010]

GeneCards Summary for PGAM1 Gene

PGAM1 (Phosphoglycerate Mutase 1 (Brain)) is a Protein Coding gene. Diseases associated with PGAM1 include phosphoglycerate mutase deficiency and corticobasal degeneration. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include protein kinase binding and bisphosphoglycerate 2-phosphatase activity. An important paralog of this gene is PGAM4.

UniProtKB/Swiss-Prot for PGAM1 Gene

  • Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC (synthase) and EC (phosphatase), but with a reduced activity

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGAM1 Gene

Genomics for PGAM1 Gene

Regulatory Elements for PGAM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PGAM1 Gene

97,426,160 bp from pter
97,433,441 bp from pter
7,282 bases
Plus strand

Genomic View for PGAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGAM1 Gene

Proteins for PGAM1 Gene

  • Protein details for PGAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphoglycerate mutase 1
    Protein Accession:
    Secondary Accessions:
    • Q9BWC0

    Protein attributes for PGAM1 Gene

    254 amino acids
    Molecular mass:
    28804 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PGAM1 Gene

neXtProt entry for PGAM1 Gene

Proteomics data for PGAM1 Gene at MOPED

Selected DME Specific Peptides for PGAM1 Gene

Post-translational modifications for PGAM1 Gene

  • Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.
  • Ubiquitination at Lys5, Lys39, Lys100, Lys106, Lys138, Lys157, Lys195, and Lys241
  • Modification sites at PhosphoSitePlus

Other Protein References for PGAM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PGAM1 (PGAM1)

Domains for PGAM1 Gene

Gene Families for PGAM1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
  • Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
genes like me logo Genes that share domains with PGAM1: view

Function for PGAM1 Gene

Molecular function for PGAM1 Gene

GENATLAS Biochemistry:
phosphoglycerate mutase 1,brain isoform,glycolysis,energy pathway
UniProtKB/Swiss-Prot CatalyticActivity:
2-phospho-D-glycerate = 3-phospho-D-glycerate
UniProtKB/Swiss-Prot CatalyticActivity:
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate
UniProtKB/Swiss-Prot CatalyticActivity:
2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate
UniProtKB/Swiss-Prot Function:
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC (synthase) and EC (phosphatase), but with a reduced activity

Enzyme Numbers (IUBMB) for PGAM1 Gene

Gene Ontology (GO) - Molecular Function for PGAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004082 bisphosphoglycerate mutase activity IEA --
GO:0004083 bisphosphoglycerate 2-phosphatase activity IEA --
GO:0004619 phosphoglycerate mutase activity NAS 2846554
GO:0005515 protein binding IPI 20849852
GO:0016868 intramolecular transferase activity, phosphotransferases --
genes like me logo Genes that share ontologies with PGAM1: view

Animal Model Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for PGAM1 Gene

Localization for PGAM1 Gene

Subcellular locations from

Jensen Localization Image for PGAM1 Gene COMPARTMENTS Subcellular localization image for PGAM1 gene
Compartment Confidence
cytosol 5
nucleus 2
chloroplast 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PGAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22590500
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PGAM1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PGAM1 Gene

Pathways for PGAM1 Gene

genes like me logo Genes that share pathways with PGAM1: view

Pathways by source for PGAM1 Gene

1 Cell Signaling Technology pathway for PGAM1 Gene
1 BioSystems pathway for PGAM1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PGAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IDA 22590500
GO:0006110 regulation of glycolytic process IDA 12189148
genes like me logo Genes that share ontologies with PGAM1: view

Drugs for PGAM1 Gene

(7) HMDB Compounds for PGAM1 Gene

Compound Synonyms Cas Number PubMed IDs
2,3-Diphosphoglyceric acid
  • (2R)-2,3-bis(phosphonooxy)-Propanoate
2-Phospho-D-glyceric acid
  • (2R)-3-hydroxy-2-(phosphonooxy)propanoate
2-Phosphoglyceric acid
  • 2-(Dihydrogen phosphate)Glycerate
3-Phosphoglyceric acid
  • 3-(Dihydrogen phosphate)Glycerate
Glyceric acid 1,3-biphosphate
  • 1,3-Biphosphoglycerate

(2) Novoseek inferred chemical compound relationships for PGAM1 Gene

Compound -log(P) Hits PubMed IDs
glyceraldehyde 3-phosphate 63.7 6
manganese superoxide 57.1 1
genes like me logo Genes that share compounds with PGAM1: view

Transcripts for PGAM1 Gene

mRNA/cDNA for PGAM1 Gene

Unigene Clusters for PGAM1 Gene

Phosphoglycerate mutase 1 (brain):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGAM1 Gene

No ASD Table

Relevant External Links for PGAM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGAM1 Gene

mRNA expression in normal human tissues for PGAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGAM1 Gene

SOURCE GeneReport for Unigene cluster for PGAM1 Gene Hs.632918

mRNA Expression by UniProt/SwissProt for PGAM1 Gene

Tissue specificity: In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues
genes like me logo Genes that share expressions with PGAM1: view

Expression partners for PGAM1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PGAM1 Gene

Orthologs for PGAM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGAM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PGAM1 35
  • 93.7 (n)
  • 99.21 (a)
-- 36
  • 92 (a)
(Canis familiaris)
Mammalia PGAM1 35
  • 94.62 (n)
  • 99.61 (a)
PGAM1 36
  • 66 (a)
(Mus musculus)
Mammalia Pgam1 35
  • 90.94 (n)
  • 99.61 (a)
Pgam1 16
Pgam1 36
  • 100 (a)
(Pan troglodytes)
Mammalia PGAM1 35
  • 99.48 (n)
  • 100 (a)
PGAM1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pgam1 35
  • 90.68 (n)
  • 97.24 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
(Gallus gallus)
Aves PGAM1 35
  • 82.15 (n)
  • 92.91 (a)
PGAM1 36
  • 95 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgam1 35
  • 76.64 (n)
  • 87.8 (a)
(Danio rerio)
Actinopterygii Dr.27123 35
pgam1b 35
  • 77.95 (n)
  • 90.16 (a)
pgam1a 36
  • 90 (a)
pgam1b 36
  • 91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7059 37
  • 39 (a)
Pglym78 37
  • 68 (a)
Pglym87 37
  • 63 (a)
Pglym78 35
  • 68.93 (n)
  • 68.8 (a)
Pglym78 36
  • 67 (a)
Pglym87 36
  • 55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001420 35
  • 63.62 (n)
  • 64.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPM1 36
  • 51 (a)
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G22170 35
  • 50.54 (n)
  • 47.83 (a)
(Oryza sativa)
Liliopsida Os02g0751800 35
  • 51.81 (n)
  • 47.83 (a)
(Zea mays)
Liliopsida Zm.8551 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4977 36
  • 64 (a)
Species with no ortholog for PGAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGAM1 Gene

Gene Tree for PGAM1 (if available)
Gene Tree for PGAM1 (if available)

Paralogs for PGAM1 Gene

Paralogs for PGAM1 Gene

(3) SIMAP similar genes for PGAM1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PGAM1: view

Variants for PGAM1 Gene

Sequence variations from dbSNP and Humsavar for PGAM1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs764223 -- 97,432,178(+) TTAAT(A/G)GCTGA intron-variant
rs2861949 -- 97,430,405(+) TCTGC(C/T)TCACC missense, reference
rs2861951 -- 97,433,407(+) CTTTT(A/T)CCATA utr-variant-3-prime
rs3834896 -- 97,427,171(-) TTTAA(-/A)GGCAC intron-variant
rs3979508 -- 97,432,647(+) GCAGA(C/T)GGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PGAM1 Gene

Variant ID Type Subtype PubMed ID
nsv467440 CNV Loss 19166990

Relevant External Links for PGAM1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGAM1 Gene

Disorders for PGAM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PGAM1 Gene in MalaCards »

(2) Diseases for PGAM1 Gene

(1) University of Copenhagen DISEASES for PGAM1 Gene

(2) Novoseek inferred disease relationships for PGAM1 Gene

Disease -log(P) Hits PubMed IDs
cancer 0.799 3
tumors 0 2
genes like me logo Genes that share disorders with PGAM1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for PGAM1 Gene

Publications for PGAM1 Gene

  1. Isolation of a cDNA encoding the B isozyme of human phosphoglycerate mutase (PGAM) and characterization of the PGAM gene family. (PMID: 2846553) Sakoda S. … Schon E.A. (J. Biol. Chem. 1988) 2 3 4
  2. Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry. (PMID: 2846554) Blouquit Y. … Rosa J. (J. Biol. Chem. 1988) 3 4
  3. Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease. (PMID: 19686046) Sultana R. … Butterfield D.A. (Antioxid. Redox Signal. 2010) 3 23
  4. Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. (PMID: 20403181) Ren F. … Huang C. (Mol. Cancer 2010) 3 23
  5. A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase. (PMID: 12189148) Shalom-Barak T. … Knaus U.G. (J. Biol. Chem. 2002) 3 23

Products for PGAM1 Gene

Sources for PGAM1 Gene

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