Aliases for PGAM1 Gene
External Ids for PGAM1 Gene
Previous HGNC Symbols for PGAM1 Gene
Previous GeneCards Identifiers for PGAM1 Gene
The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for PGAM1 Gene
PGAM1 (Phosphoglycerate Mutase 1) is a Protein Coding gene. Diseases associated with PGAM1 include Phosphoglycerate Mutase Deficiency and Corticobasal Degeneration. Among its related pathways are Glycosaminoglycan metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include protein kinase binding and bisphosphoglycerate mutase activity. An important paralog of this gene is PGAM4.
UniProtKB/Swiss-Prot for PGAM1 Gene
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 22.214.171.124 (synthase) and EC 126.96.36.199 (phosphatase), but with a reduced activity.