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Aliases for PGA5 Gene

Aliases for PGA5 Gene

  • Pepsinogen 5, Group I (Pepsinogen A) 2 3 5
  • Pepsinogen-5 3 4
  • Pepsinogen A5 3
  • EC 4
  • Pepsin A-5 3
  • Pepsin A 3
  • Pg5 3

External Ids for PGA5 Gene

Previous GeneCards Identifiers for PGA5 Gene

  • GC11U990102
  • GC11P062521
  • GC11P060786
  • GC11P060788
  • GC11P060767
  • GC11P060991
  • GC11P061008

Summaries for PGA5 Gene

Entrez Gene Summary for PGA5 Gene

  • This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]

GeneCards Summary for PGA5 Gene

PGA5 (Pepsinogen 5, Group I (Pepsinogen A)) is a Protein Coding gene. Diseases associated with PGA5 include Atrophic Gastritis and Gastritis. Among its related pathways are Collagen chain trimerization and Surfactant metabolism. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is PGA4.

UniProtKB/Swiss-Prot for PGA5 Gene

  • Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

Gene Wiki entry for PGA5 Gene

Additional gene information for PGA5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGA5 Gene

Genomics for PGA5 Gene

GeneHancer (GH) Regulatory Elements for PGA5 Gene

Promoters and enhancers for PGA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I061240 Promoter 0.6 EPDnew 550.8 0.0 -32 0.1 ZNF512 PGA5 ENSG00000256220
GH11I061293 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.2 +53.7 53696 2.6 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 SLC30A9 GLIS2 SP5 MXD4 VWCE PGA5
GH11I061254 Enhancer 0.7 ENCODE 0.4 +13.6 13562 0.2 HDGF CTCF PKNOX1 RB1 ARID4B EBF1 RAD21 CTBP1 ARID2 POLR2A VWCE DDB1 TKFC PGA5
GH11I061282 Enhancer 0.9 Ensembl ENCODE 0.3 +40.8 40833 0.9 KLF1 SREBF2 MAX CCNT2 POLR2A EGR1 VEZF1 KLF8 SP3 ZNF740 TKFC DDB1 TMEM216 VWCE PGA5
GH11I061267 Enhancer 0.8 ENCODE 0.3 +26.6 26582 0.2 FOXA2 RB1 MLX ARID4B ZNF48 RARA YY1 RXRA SP5 MXD4 VWCE DDB1 TKFC PGA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PGA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGA5 gene promoter:

Genomic Locations for PGA5 Gene

Genomic Locations for PGA5 Gene
10,416 bases
Plus strand

Genomic View for PGA5 Gene

Genes around PGA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGA5 Gene

Proteins for PGA5 Gene

  • Protein details for PGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pepsin A-5
    Protein Accession:
    Secondary Accessions:
    • A8K749
    • B7ZW62
    • B7ZW75
    • P00790
    • Q7M4R0
    • Q8N1E3

    Protein attributes for PGA5 Gene

    388 amino acids
    Molecular mass:
    41993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PGA5 Gene

Post-translational modifications for PGA5 Gene

No Post-translational modifications

Other Protein References for PGA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PGA5 Gene

Domains & Families for PGA5 Gene

Gene Families for PGA5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PGA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase A1 family.
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with PGA5: view

Function for PGA5 Gene

Molecular function for PGA5 Gene

GENATLAS Biochemistry:
pepsinogen 5,group I (pepsinogen A),clustered with PGA3,PGA4
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1 positions. Cleaves 1-Phe- -Val-2, 4-Gln- -His-5, 13-Glu- -Ala-14, 14-Ala- -Leu-15, 15-Leu- -Tyr-16, 16-Tyr- -Leu-17, 23-Gly- -Phe-24, 24-Phe- -Phe-25 and 25-Phe- -Tyr-26 bonds in the B chain of insulin.
UniProtKB/Swiss-Prot Function:
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

Enzyme Numbers (IUBMB) for PGA5 Gene

Gene Ontology (GO) - Molecular Function for PGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IBA --
GO:0008233 peptidase activity TAS,IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PGA5: view
genes like me logo Genes that share phenotypes with PGA5: view

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PGA5 Gene

Localization for PGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGA5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGA5 gene
Compartment Confidence
extracellular 5
endosome 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
GO:0097486 multivesicular body lumen TAS --
genes like me logo Genes that share ontologies with PGA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PGA5 Gene

Pathways & Interactions for PGA5 Gene

genes like me logo Genes that share pathways with PGA5: view

Pathways by source for PGA5 Gene

2 Reactome pathways for PGA5 Gene
1 KEGG pathway for PGA5 Gene

Interacting Proteins for PGA5 Gene

Gene Ontology (GO) - Biological Process for PGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IBA --
GO:0006914 autophagy IBA --
GO:0007586 digestion IEA --
GO:0030163 protein catabolic process IBA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PGA5: view

No data available for SIGNOR curated interactions for PGA5 Gene

Drugs & Compounds for PGA5 Gene

No Compound Related Data Available

Transcripts for PGA5 Gene

mRNA/cDNA for PGA5 Gene

Unigene Clusters for PGA5 Gene

Pepsinogen 5, group I (pepsinogen A):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGA5 Gene

No ASD Table

Relevant External Links for PGA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGA5 Gene

This gene is overexpressed in Stomach (x52.9).

Protein differential expression in normal tissues from HIPED for PGA5 Gene

This gene is overexpressed in Urine (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PGA5 Gene

Protein tissue co-expression partners for PGA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PGA5 Gene:


SOURCE GeneReport for Unigene cluster for PGA5 Gene:


Evidence on tissue expression from TISSUES for PGA5 Gene

  • Stomach(4.4)
  • Nervous system(4.3)
  • Intestine(4.1)
  • Kidney(4)
genes like me logo Genes that share expression patterns with PGA5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGA5 Gene

Orthologs for PGA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PGA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGA4 33
  • 99.05 (n)
-- 34
  • 99 (a)
(Canis familiaris)
Mammalia PGA 33 34
  • 85.66 (n)
(Bos Taurus)
Mammalia PGA5 33
  • 84.54 (n)
PGA 34
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
(Gallus gallus)
Aves LOC395926 33
  • 63.34 (n)
PGA 34
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pga4 33
  • 67.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia pga-A 33
Species where no ortholog for PGA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PGA5 Gene

Gene Tree for PGA5 (if available)
Gene Tree for PGA5 (if available)

Paralogs for PGA5 Gene

Paralogs for PGA5 Gene

(8) SIMAP similar genes for PGA5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PGA5: view

Variants for PGA5 Gene

Sequence variations from dbSNP and Humsavar for PGA5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000278023 -- 61,247,559(+) G/A intron_variant
rs1000705657 -- 61,250,582(+) G/A intron_variant
rs1000944254 -- 61,250,792(+) G/C/T intron_variant
rs1001177376 -- 61,251,004(+) A/C intron_variant
rs1001195355 -- 61,249,475(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PGA5 Gene

Variant ID Type Subtype PubMed ID
esv2744587 CNV deletion 23290073
esv2759831 CNV gain+loss 17122850
esv29298 CNV gain+loss 19812545
esv3350259 CNV duplication 20981092
esv3353952 CNV duplication 20981092
esv3425930 CNV duplication 20981092
esv3579734 CNV loss 25503493
esv3626575 CNV loss 21293372
esv3626576 CNV gain 21293372
nsv1118213 CNV deletion 24896259
nsv339 CNV deletion 18451855
nsv341 CNV insertion 18451855
nsv428259 CNV gain+loss 18775914
nsv514629 CNV gain 21397061
nsv555162 CNV loss 21841781
nsv820586 CNV deletion 20802225
nsv825937 CNV loss 20364138
nsv832177 CNV loss 17160897
nsv8833 CNV gain 18304495
nsv952458 CNV duplication 24416366
nsv975192 CNV duplication 23825009

Variation tolerance for PGA5 Gene

Gene Damage Index Score: 2.18; 39.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGA5 Gene

Disorders for PGA5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PGA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
atrophic gastritis
  • gastric atrophy
  • acute gastric mucosal erosion
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search PGA5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PGA5

genes like me logo Genes that share disorders with PGA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGA5 Gene

Publications for PGA5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Crystal structure of human pepsin and its complex with pepstatin. (PMID: 7663352) Fujinaga M … James MN (Protein science : a publication of the Protein Society 1995) 3 4 58
  3. A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins. (PMID: 2515193) Athauda SB … Takahashi K (Journal of biochemistry 1989) 3 4 58
  4. Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. (PMID: 2714789) Evers MP … Eriksson AW (Genomics 1989) 3 4 58
  5. Activation of human pepsinogens. (PMID: 3197840) Foltmann B (FEBS letters 1988) 3 4 58

Products for PGA5 Gene

Sources for PGA5 Gene

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