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Aliases for PGA4 Gene

Aliases for PGA4 Gene

  • Pepsinogen 4, Group I (Pepsinogen A) 2 3 5
  • Pepsinogen-4 3 4
  • Pepsinogen A4 3
  • EC 3.4.23.1 4

External Ids for PGA4 Gene

Previous GeneCards Identifiers for PGA4 Gene

  • GC11U990101
  • GC11P060765
  • GC11P060727
  • GC11P060747
  • GC11P060739
  • GC11P060989

Summaries for PGA4 Gene

Entrez Gene Summary for PGA4 Gene

  • This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]

GeneCards Summary for PGA4 Gene

PGA4 (Pepsinogen 4, Group I (Pepsinogen A)) is a Protein Coding gene. Diseases associated with PGA4 include atrophic gastritis and gastritis. Among its related pathways are Protein digestion and absorption and Transport to the Golgi and subsequent modification. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is REN.

UniProtKB/Swiss-Prot for PGA4 Gene

  • Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGA4 Gene

Genomics for PGA4 Gene

Regulatory Elements for PGA4 Gene

Enhancers for PGA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PGA4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PGA4 gene promoter:

Genomic Location for PGA4 Gene

Chromosome:
11
Start:
61,222,216 bp from pter
End:
61,231,927 bp from pter
Size:
9,712 bases
Orientation:
Plus strand

Genomic View for PGA4 Gene

Genes around PGA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGA4 Gene

Proteins for PGA4 Gene

  • Protein details for PGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJD7-PEPA4_HUMAN
    Recommended name:
    Pepsin A-4
    Protein Accession:
    P0DJD7
    Secondary Accessions:
    • A8K749
    • B7ZW75
    • P00790
    • Q7M4R0
    • Q8N1E3

    Protein attributes for PGA4 Gene

    Size:
    388 amino acids
    Molecular mass:
    41977 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PGA4 Gene

neXtProt entry for PGA4 Gene

Proteomics data for PGA4 Gene at MOPED

Post-translational modifications for PGA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PGA4 Gene

Domains & Families for PGA4 Gene

Graphical View of Domain Structure for InterPro Entry

P0DJD7

UniProtKB/Swiss-Prot:

PEPA4_HUMAN :
  • Contains 1 peptidase A1 domain.
  • Belongs to the peptidase A1 family.
Domain:
  • Contains 1 peptidase A1 domain.
Family:
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with PGA4: view

No data available for Gene Families for PGA4 Gene

Function for PGA4 Gene

Molecular function for PGA4 Gene

GENATLAS Biochemistry:
pepsinogen 4,group I (pepsinogen A),clustered with PGA3,PGA5
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1 positions. Cleaves 1-Phe- -Val-2, 4-Gln- -His-5, 13-Glu- -Ala-14, 14-Ala- -Leu-15, 15-Leu- -Tyr-16, 16-Tyr- -Leu-17, 23-Gly- -Phe-24, 24-Phe- -Phe-25 and 25-Phe- -Tyr-26 bonds in the B chain of insulin.
UniProtKB/Swiss-Prot Function:
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

Enzyme Numbers (IUBMB) for PGA4 Gene

genes like me logo Genes that share phenotypes with PGA4: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PGA4 Gene

Localization for PGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGA4 Gene COMPARTMENTS Subcellular localization image for PGA4 gene
Compartment Confidence
extracellular 5
endosome 4

No data available for Gene Ontology (GO) - Cellular Components for PGA4 Gene

Pathways & Interactions for PGA4 Gene

genes like me logo Genes that share pathways with PGA4: view

Pathways by source for PGA4 Gene

2 Reactome pathways for PGA4 Gene
1 KEGG pathway for PGA4 Gene

Interacting Proteins for PGA4 Gene

Gene Ontology (GO) - Biological Process for PGA4 Gene

None

No data available for SIGNOR curated interactions for PGA4 Gene

Drugs & Compounds for PGA4 Gene

No Compound Related Data Available

Transcripts for PGA4 Gene

mRNA/cDNA for PGA4 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGA4 Gene

Pepsinogen 4, group I (pepsinogen A):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGA4 Gene

No ASD Table

Relevant External Links for PGA4 Gene

GeneLoc Exon Structure for
PGA4
ECgene alternative splicing isoforms for
PGA4

Expression for PGA4 Gene

mRNA expression in normal human tissues for PGA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGA4 Gene

This gene is overexpressed in Stomach (x52.6).

SOURCE GeneReport for Unigene cluster for PGA4 Gene Hs.661883

genes like me logo Genes that share expression patterns with PGA4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PGA4 Gene

Orthologs for PGA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PGA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGA5 35
  • 84.72 (n)
  • 82.38 (a)
PGA 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PGA 35
  • 86.1 (n)
  • 82.64 (a)
PGA 36
  • 82 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PGA4 35
  • 99.14 (n)
  • 98.71 (a)
-- 36
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cym 36
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC395926 35
  • 63.53 (n)
  • 59 (a)
PGA 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pga4 35
  • 68.14 (n)
  • 69.01 (a)
Species with no ortholog for PGA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PGA4 Gene

ENSEMBL:
Gene Tree for PGA4 (if available)
TreeFam:
Gene Tree for PGA4 (if available)

Paralogs for PGA4 Gene

Paralogs for PGA4 Gene

(8) SIMAP similar genes for PGA4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PGA4: view

Variants for PGA4 Gene

Sequence variations from dbSNP and Humsavar for PGA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs646877 -- 61,223,666(+) CGGTC(C/T)GAGGA intron-variant
rs647961 -- 61,221,659(-) GGGCA(C/T)GCAGC upstream-variant-2KB
rs651545 -- 61,220,922(-) AGGTT(A/G)TGAGA upstream-variant-2KB
rs948733 -- 61,230,713(+) TTTCC(A/G)TAGGC intron-variant
rs11607442 -- 61,220,859(-) CTTTA(A/C/G/T)CTAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PGA4 Gene

Variant ID Type Subtype PubMed ID
nsv832176 CNV Gain+Loss 17160897
nsv428259 CNV Gain+Loss 18775914
dgv390e1 CNV Complex 17122850
nsv832177 CNV Loss 17160897
nsv820586 CNV Deletion 20802225
nsv825937 CNV Loss 20364138
nsv8833 CNV Gain 18304495
esv29298 CNV Gain+Loss 19812545
esv1004439 CNV Deletion 20482838
nsv339 CNV Loss 18451855
nsv514629 CNV Complex 21397061
nsv509414 CNV Insertion 20534489
nsv340 CNV Insertion 18451855
esv2744587 CNV Deletion 23290073

Variation tolerance for PGA4 Gene

Gene Damage Index Score: 0.06; 1.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGA4 Gene

HapMap Linkage Disequilibrium report
PGA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGA4 Gene

Disorders for PGA4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PGA4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
atrophic gastritis
  • gastric atrophy
gastritis
  • acute gastric mucosal erosion
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search PGA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PGA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGA4
genes like me logo Genes that share disorders with PGA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGA4 Gene

Publications for PGA4 Gene

  1. Primary structure of human pepsinogen gene. (PMID: 6300126) Sogawa K. … Takahashi K. (J. Biol. Chem. 1983) 2 3 4 67
  2. A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men. (PMID: 24125879) Kutsuma A. … Nakajima K. (Clin. Biochem. 2014) 3
  3. Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay. (PMID: 24170207) Huang M. … Yang J.J. (J. Clin. Pathol. 2014) 3
  4. The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China. (PMID: 24383519) Zhang X.M. … Gu H. (BMC Gastroenterol 2014) 3
  5. Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis. (PMID: 25314140) Terasawa T. … Hamashima C. (PLoS ONE 2014) 3

Products for PGA4 Gene

Sources for PGA4 Gene

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