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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PGA3 Gene

protein-coding GIFtS: 47
GCID: GC11P060970

pepsinogen 3, group I (pepsinogen A)

Explore 13 diseases affiliated with
PGA3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Pepsinogen 3, Group I (Pepsinogen A)¹ ²		Pepsinogen A3²
PGA4²		EC 3.4.23.1³
PGA5²		Pepsinogen-3³
Pepsin A²

External Ids:	HGNC: 8885¹	Entrez Gene: 643834²	Ensembl: ENSG00000229859⁷	OMIM: 169710⁵	UniProtKB: P0DJD8³

Export aliases for PGA3 gene to outside databases

Previous GC identifers: GC11U990100 GC11P060785 GC11P060787 GC11P060766 GC11P060715

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PEPA3_HUMAN, P0DJD8

Function: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many

others are also cleaved to some extent

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for PGA3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PGA3 promoter sequence

Search SABiosciences Chromatin IP Primers for PGA3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q13

PGA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGA3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P060970: view genomic region (about GC identifiers)

Start:	60,970,779 bp from pter	End:	60,980,570 bp from pter
Size:	9,792 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PEPA3_HUMAN, P0DJD8 (See protein sequence)

Recommended Name: Pepsin A-3 precursor

Size: 388 amino acids; 41976 Da

Subcellular location: Secreted

Secondary accessions: A8K749 B2R7D6 B7ZW75 P00790 Q7M4R0 Q8N1E3

Explore the universe of human proteins at neXtProt for PGA3: NX_P0DJD8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P0DJD8

PGA3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073275.1

ENSEMBL proteins:

ENSP00000322192 ENSP00000442525 ENSP00000443732 ENSP00000440177 ENSP00000439846

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	Uscn Proteins for PGA3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--

PGA3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PGA3 for domains About GeneDecksing

4 InterPro domains/families:

IPR021109 Peptidase_aspartic

IPR001969 Peptidase_aspartic_AS

IPR012848 Propep_A1

IPR001461 Peptidase_A1

Graphical View of Domain Structure for InterPro Entry P0DJD8

ProtoNet protein and cluster: P0DJD8

UniProtKB/Swiss-Prot: PEPA3_HUMAN, P0DJD8

Similarity: Belongs to the peptidase A1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PEPA3_HUMAN, P0DJD8

Function: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many

others are also cleaved to some extent

Catalytic activity: Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves

1-Phe- -Val-2, 4-Gln- -His-5, 13-Glu- -Ala-14, 14-Ala- -Leu-15, 15-Leu- -Tyr-16, 16-Tyr- -Leu-17, 23-Gly- -Phe-24,

24-Phe- -Phe-25 and 25-Phe- -Tyr-26 bonds in the B chain of insulin

Genatlas biochemistry entry for PGA3:

pepsinogen 3,group I (pepsinogen A),clustered with PGA4,PGA5

Enzyme Number (IUBMB): EC 3.4.23.1¹

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGA3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004190	aspartic-type endopeptidase activity	--	--

PGA3 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Protein digestion and absorption

Protein digestion and absorption

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for PGA3):

Protein digestion and absorption

PGA3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PGA3

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	--	--
GO:0007586	digestion	--	--

PGA3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PGA3

6 DrugBank Compounds for PGA3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sucralfate	--	54182-58-0	target	inhibitor	1978840 2190304 1611711
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid	--	--	target	--	10592235
CYCLOHEXYL-NORSTATINE	--	--	target	--	10592235
CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	--	--	target	--	10592235
Iodo-Phenylalanine	--	--	target	--	10592235
N-(ethoxycarbonyl)-L-leucine	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about PGA3 / PEPA3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PGA3 gene:

NM_001079807.1

Unigene Cluster for PGA3:

Pepsinogen 3, group I (pepsinogen A)

Hs.601055 [show with all ESTs]

Unigene Representative Sequence: AL832946

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000535551 ENST00000325558(uc001nqx.3) ENST00000537954 ENST00000539649

ENST00000543349 ENST00000543505 ENST00000541699 ENST00000543125 ENST00000538258

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Additional cDNA sequence:

AK125628.1 AK225669.1 AK225674.1 AK225679.1 AK301286.1 AK301293.1 AK312941.1 AL832946.1

BC171815.1

16 DOTS entries:

DT.317990 DT.100797746 DT.95337356 DT.120736582 DT.100797755 DT.100797749 DT.308092 DT.95291496

DT.100797747 DT.120736600 DT.120736605 DT.120736610 DT.91761511 DT.91761536 DT.120736567 DT.308093

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PGA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCTCCCCA

About this image

PGA3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Mature Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PGA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PGA3

SOURCE GeneReport for Unigene cluster: Hs.601055

SABiosciences Custom PCR Arrays for PGA3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PGA3 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PGA¹	pepsinogen 5, group I (pepsinogen A)	69.11(n) 63.09(a)		395691 NM_204878.1 NP_990209.1
lizard (Anolis carolinensis)	Reptilia	--	--	72(a)	possible ortholog	GL343235.1(698492-707338)
fruit fly (Drosophila melanogaster)	Insecta	CG5860⁶	--	33(a)	1 → many	3R(13235341-13236562)
worm (Caenorhabditis elegans)	Secernentea	asp-1⁶ Y39B6A.23⁶ (see all 16)	--	32(a) 31(a) (see all 16)	many ↔ many many ↔ many (see all 16)	V(19049094-19050796) V(19039029-19042576)

ENSEMBL Gene Tree for PGA3 (if available)
TreeFam Gene Tree for PGA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PGA3 gene

PGA4¹ ² PGA5¹ ² BACE1² CTSD² BACE2² NAPSA² ENSG00000250644² CTSE²

PGC² ENSG00000265969² REN²

8 SIMAP similar genes for PGA3 using alignment to 5 protein entries: PEPA3_HUMAN (see all proteins):

PGA4 PGA5 DKFZp666J2410 CTSE PGC CTSD

NAPSA REN

PGA3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for PGA3
PGOHUM00000244842 PGOHUM00000259571

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188665110^1,2		--	60969003(+)	`GGAGTA/GAAGCT`	1	--	us2k¹		0	--	--	--	--
rs116843115^1,2		--	60969122(+)	`CCTTCG/ACGGTG`	1	--	us2k¹		1		EA	120
rs35143070^1,2	F,	--	60969180(+)	`GCAAGG/ATTTAT`	1	--	us2k¹		1		NA	4
rs140711746^1,2		--	60969195(+)	`AAGAGC/TGAAAG`	1	--	us2k¹		0	--	--	--	--
rs181189830^1,2		--	60969196(+)	`AGAGCA/GAAAGA`	1	--	us2k¹		0	--	--	--	--
rs144557411^1,2		--	60969291(+)	`CCACAC/TACATC`	1	--	us2k¹		0	--	--	--	--
rs78297094^1,2	C,F	--	60969386(+)	`GGTCCG/ATTTTG`	1	--	us2k¹		2		NA	6
rs146636587^1,2		--	60969404(+)	`ATGCTA/GATTGG`	1	--	us2k¹		0	--	--	--	--
rs141327636^1,2		--	60969406(+)	`GCTGAC/TTGGTG`	1	--	us2k¹		0	--	--	--	--
rs187035494^1,2		--	60969427(+)	`CCTTCA/TGCTAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PGA3 (60970779 - 60980570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for PGA3
15/16 CNVs (see all 16): 34992 85810 0420 34994 85811 85812 4748 30556 34995 85813 3854 34997 4747 75677 65969

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PGA3 for disorders           About GeneDecksing

OMIM gene information: 169710    OMIM disorders: --

13 diseases for PGA3:    About MalaCards

pernicious anemia atrophic gastritis megaloblastic anemia barrett's esophagus

peptic ulcer duodenal ulcer gastritis duodenitis

anemia gastric cancer esophagitis malaria

neuronitis

1 disease from the University of Copenhagen DISEASES database for PGA3:

Megaloblastic anemia

Export disorders for PGA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PGA3 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with PGA3)

Utopia: connect your pdf to the dynamic
world of online information

Primary structure of human pepsinogen gene. (PubMed id 6300126)^{1, 2, 3} Sogawa K.... Takahashi K. (1983)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study. (PubMed id 21175799)¹ Peitz U....Malfertheiner P. (2011)
Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan. (PubMed id 19196398)¹ Abe Y....Shimosegawa T. (2009)
Serum pepsinogens and risk of esophageal squamous dysplasia. (PubMed id 18844222)¹ Kamangar F....Dawsey S.M. (2009)
Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. (PubMed id 17559360)¹ Pimanov S.I....Voropaev E.V. (2008)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
Histologic and serum risk markers for noncardia early gastric cancer. (PubMed id 15688378)¹ Shiotani A....Graham D.Y. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 643834	HGNC: 8885	Ensembl:ENSG00000229859	euGenes: HUgn643834	ECgene: PGA3	Kegg: 643834
H-InvDB: PGA3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PGA3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PGA3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PGA3 gene:
Search GeneIP for patents involving PGA3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PGA3
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PGA3 gene at Home site.

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PGA3 Gene

pepsinogen 3, group I (pepsinogen A)

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PGA3 Gene

pepsinogen 3, group I (pepsinogen A)

Aliasesfor PGA3 gene

Summariesfor PGA3 gene

Genomic Viewsfor PGA3 gene

Proteinsfor PGA3 gene

Protein Domains /Familiesfor PGA3 gene

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