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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGA3 Gene

protein-coding   GIFtS: 45
GCID: GC11P060970

Pepsinogen 3, Group I (Pepsinogen A)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pepsinogen 3, Group I (Pepsinogen A)1 2     Pepsinogen A32
PGA42     EC 3.4.23.13
PGA52     Pepsinogen-33
Pepsin A2     

External Ids:    HGNC: 88851   Entrez Gene: 6438342   Ensembl: ENSG000002298597   OMIM: 1697105   UniProtKB: P0DJD83   

Export aliases for PGA3 gene to outside databases

Previous GC identifers: GC11U990100 GC11P060785 GC11P060787 GC11P060766 GC11P060715


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PGA3 Gene: 
PGA3 (pepsinogen 3, group I (pepsinogen A)) is a protein-coding gene. Diseases associated with PGA3 include pernicious anemia, and atrophic gastritis. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot: PEPA3_HUMAN, P0DJD8
Function: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred,
many others are also cleaved to some extent




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PGA3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPGA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PGA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q13

PGA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGA3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060970:  view genomic region     (about GC identifiers)

Start:
60,970,779 bp from pter      End:
60,980,570 bp from pter
Size:
9,792 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PEPA3_HUMAN, P0DJD8 (See protein sequence)
Recommended Name: Pepsin A-3 precursor  
Size: 388 amino acids; 41976 Da
Subcellular location: Secreted
Secondary accessions: A8K749 B2R7D6 B7ZW75 P00790 Q7M4R0 Q8N1E3

Explore the universe of human proteins at neXtProt for PGA3: NX_P0DJD8

Explore proteomics data for PGA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0DJD8

  • PGA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PGA3 Protein Expression
    REFSEQ proteins: NP_001073275.1  
    ENSEMBL proteins: 
     ENSP00000322192   ENSP00000442525   ENSP00000443732   ENSP00000440177   ENSP00000439846  

    Human Recombinant Protein Products for PGA3: 
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    Cloud-Clone Corp. Proteins for PGA3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    PGA3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for PGA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR021109 Peptidase_aspartic
     IPR001969 Peptidase_aspartic_AS
     IPR012848 Propep_A1
     IPR001461 Peptidase_A1

    Graphical View of Domain Structure for InterPro Entry P0DJD8

    ProtoNet protein and cluster: P0DJD8

    UniProtKB/Swiss-Prot: PEPA3_HUMAN, P0DJD8
    Similarity: Belongs to the peptidase A1 family


    PGA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PEPA3_HUMAN, P0DJD8
    Function: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred,
    many others are also cleaved to some extent
    Catalytic activity: Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions.
    Cleaves 1-Phe- -Val-2, 4-Gln- -His-5, 13-Glu- -Ala-14, 14-Ala- -Leu-15, 15-Leu- -Tyr-16, 16-Tyr- -Leu-17, 23-Gly-
    -Phe-24, 24-Phe- -Phe-25 and 25-Phe- -Tyr-26 bonds in the B chain of insulin

         Genatlas biochemistry entry for PGA3:
    pepsinogen 3,group I (pepsinogen A),clustered with PGA4,PGA5

         Enzyme Number (IUBMB): EC 3.4.23.11

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity ----
         
    PGA3 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PGA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein digestion and absorption
    Protein digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for PGA3):
        Protein digestion and absorption


    PGA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PGA3

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007586digestion ----

    PGA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGA3 (PEPA3)

    6 DrugBank Compounds for PGA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sucralfate-- 54182-58-0targetinhibitor1978840 2190304 1611711
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    CYCLOHEXYL-NORSTATINE-- --target--10592235
    CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE-- --target--10592235
    Iodo-Phenylalanine-- --target--10592235
    N-(ethoxycarbonyl)-L-leucine-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about PGA3 / PEPA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PGA3 gene: 
    NM_001079807.1  

    Unigene Cluster for PGA3:

    Pepsinogen 3, group I (pepsinogen A)
    Hs.601055  [show with all ESTs]
    Unigene Representative Sequence: AL832946
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535551 ENST00000325558(uc001nqx.3) ENST00000537954 ENST00000539649
    ENST00000543349 ENST00000543505 ENST00000541699 ENST00000543125 ENST00000538258

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGA3

    Additional mRNA sequence: 

    AK125628.1 AK225669.1 AK225674.1 AK225679.1 AK301286.1 AK301293.1 AK312941.1 AL832946.1 
    BC171815.1 

    16 DOTS entries:

    DT.317990  DT.100797746  DT.95337356  DT.120736582  DT.100797755  DT.100797749  DT.308092  DT.95291496 
    DT.100797747  DT.120736600  DT.120736605  DT.120736610  DT.91761511  DT.91761536  DT.120736567  DT.308093 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGA3 expression in normal human tissues (normalized intensities)      PGA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTCCCCA
    PGA3 Expression
    About this image


    PGA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Stomach (Gastrointestinal Tract)
             stomach cardiac   
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Heart (Cardiovascular System)
             DKK1-induced cells ( Derivation of cardiomyocytes from pluripotent stem cells and...
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Mesoderm (Gastrulation Derivatives)
             Mesoderm-like cells ( Derivation of cardiomyocytes from pluripotent stem cells and...

    See PGA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGA3

    SOURCE GeneReport for Unigene cluster: Hs.601055
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PGA3 gene from 3/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia PGA1 pepsinogen 5, group I (pepsinogen A) 86.18(n)
    82.64(a)
      403711  NM_001003117.1  NP_001003117.1 
    chicken
    (Gallus gallus)
    Aves PGA1 pepsinogen 5, group I (pepsinogen A) 69.11(n)
    63.09(a)
      395691  NM_204878.1  NP_990209.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    72(a)
    possible ortholog
    GL343235.1(698492-707338)


    ENSEMBL Gene Tree for PGA3 (if available)
    TreeFam Gene Tree for PGA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGA3 gene
    PGA41 2  PGA51 2  BACE12  CTSD2  BACE22  NAPSA2  CTSE2  PGC2  
    REN2  
    8 SIMAP similar genes for PGA3 using alignment to 5 protein entries:     PEPA3_HUMAN (see all proteins):
    PGA4    PGA5    DKFZp666J2410    CTSE    PGC    CTSD
    REN    NAPSA

    PGA3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PGA3
    PGOHUM00000244842 PGOHUM00000259571


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/171 SNPs in PGA3 are shown (see all 171)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886651101,2
    --60969003(+) GGAGTA/GAAGCT 1 -- us2k10--------
    rs1168431151,2
    F--60969122(+) CCTTCG/ACGGTG 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs351430701,2
    F--60969180(+) GCAAGG/ATTTAT 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs1407117461,2
    --60969195(+) AAGAGC/TGAAAG 1 -- us2k10--------
    rs1811898301,2
    --60969196(+) AGAGCA/GAAAGA 1 -- us2k10--------
    rs1445574111,2
    --60969291(+) CCACAC/TACATC 1 -- us2k10--------
    rs782970941,2
    C,F--60969386(+) GGTCCG/ATTTTG 1 -- us2k12Minor allele frequency- A:0.33NA 6
    rs1466365871,2
    --60969404(+) ATGCTA/GATTGG 1 -- us2k10--------
    rs1413276361,2
    --60969406(+) GCTGAC/TTGGTG 1 -- us2k10--------
    rs1870354941,2
    --60969427(+) CCTTCA/TGCTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PGA3 (60970779 - 60980570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PGA3 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv820586CNV Deletion20802225
    esv1004439CNV Deletion20482838
    nsv436823CNV Insertion17901297
    nsv72CNV Insertion15895083
    nsv338CNV Insertion18451855
    nsv825937CNV Loss20364138
    nsv832177CNV Loss17160897
    nsv339CNV Loss18451855
    nsv8833CNV Gain18304495
    nsv428259CNV Gain+Loss18775914

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 169710    OMIM disorders: --

    11 diseases for PGA3:    About MalaCards
    pernicious anemia    atrophic gastritis    duodenal ulcer    megaloblastic anemia
    duodenitis    peptic ulcer    gastritis    barrett's esophagus
    anemia    gastric cancer    esophagitis


    PGA3 for disorders           About GeneDecksing


    Export disorders for PGA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGA3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with PGA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human pepsinogen gene. (PubMed id 6300126)1, 2, 3 Sogawa K.... Takahashi K. (1983)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study. (PubMed id 21175799)1 Peitz U....Malfertheiner P. (2011)
    4. Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan. (PubMed id 19196398)1 Abe Y....Shimosegawa T. (2009)
    5. Serum pepsinogens and risk of esophageal squamous dysplasia. (PubMed id 18844222)1 Kamangar F....Dawsey S.M. (2009)
    6. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. (PubMed id 17559360)1 Pimanov S.I....Voropaev E.V. (2008)
    7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    8. Histologic and serum risk markers for noncardia early gastric cancer. (PubMed id 15688378)1 Shiotani A....Graham D.Y. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 643834 HGNC: 8885 Ensembl:ENSG00000229859 euGenes: HUgn643834 ECgene: PGA3 Kegg: 643834
    H-InvDB: PGA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PGA3 gene:
    Search GeneIP for patents involving PGA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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