Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PGA3 Gene

Aliases for PGA3 Gene

  • Pepsinogen 3, Group I (Pepsinogen A) 2 3
  • Pepsinogen-3 3 4
  • Pepsinogen A3 3
  • EC 3.4.23.1 4
  • Pepsin A-3 3
  • Pepsin A 3

External Ids for PGA3 Gene

Previous GeneCards Identifiers for PGA3 Gene

  • GC11U990100
  • GC11P060785
  • GC11P060787
  • GC11P060766
  • GC11P060715
  • GC11P060970

Summaries for PGA3 Gene

GeneCards Summary for PGA3 Gene

PGA3 (Pepsinogen 3, Group I (Pepsinogen A)) is a Protein Coding gene. Among its related pathways are Protein digestion and absorption. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot for PGA3 Gene

  • Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGA3 Gene

Genomics for PGA3 Gene

Genomic Location for PGA3 Gene

Start:
61,203,307 bp from pter
End:
61,213,098 bp from pter
Size:
9,792 bases
Orientation:
Plus strand

Genomic View for PGA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGA3 Gene

No data available for Regulatory Elements for PGA3 Gene

Proteins for PGA3 Gene

  • Protein details for PGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJD8-PEPA3_HUMAN
    Recommended name:
    Pepsin A-3
    Protein Accession:
    P0DJD8
    Secondary Accessions:
    • A8K749
    • B2R7D6
    • B7ZW75
    • P00790
    • Q7M4R0
    • Q8N1E3

    Protein attributes for PGA3 Gene

    Size:
    388 amino acids
    Molecular mass:
    41976 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PGA3 Gene

Proteomics data for PGA3 Gene at MOPED

Post-translational modifications for PGA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGA3 Gene

No data available for DME Specific Peptides for PGA3 Gene

Domains for PGA3 Gene

Suggested Antigen Peptide Sequences for PGA3 Gene

Graphical View of Domain Structure for InterPro Entry

P0DJD8

UniProtKB/Swiss-Prot:

PEPA3_HUMAN :
  • P0DJD8
Family:
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with PGA3: view

No data available for Gene Families for PGA3 Gene

Function for PGA3 Gene

Molecular function for PGA3 Gene

GENATLAS Biochemistry:
pepsinogen 3,group I (pepsinogen A),clustered with PGA4,PGA5
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1 positions. Cleaves 1-Phe- -Val-2, 4-Gln- -His-5, 13-Glu- -Ala-14, 14-Ala- -Leu-15, 15-Leu- -Tyr-16, 16-Tyr- -Leu-17, 23-Gly- -Phe-24, 24-Phe- -Phe-25 and 25-Phe- -Tyr-26 bonds in the B chain of insulin.
UniProtKB/Swiss-Prot Function:
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent

Enzyme Numbers (IUBMB) for PGA3 Gene

Gene Ontology (GO) - Molecular Function for PGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PGA3: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGA3

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PGA3 Gene

Localization for PGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGA3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGA3 Gene COMPARTMENTS Subcellular localization image for PGA3 gene
Compartment Confidence
extracellular 5
lysosome 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PGA3: view

Pathways for PGA3 Gene

genes like me logo Genes that share pathways with PGA3: view

Pathways by source for PGA3 Gene

1 KEGG pathway for PGA3 Gene

Interacting Proteins for PGA3 Gene

Gene Ontology (GO) - Biological Process for PGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion IEA --
genes like me logo Genes that share ontologies with PGA3: view

Transcripts for PGA3 Gene

mRNA/cDNA for PGA3 Gene

(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PGA3 Gene

Pepsinogen 3, group I (pepsinogen A):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGA3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGA3 Gene

No ASD Table

Relevant External Links for PGA3 Gene

GeneLoc Exon Structure for
PGA3
ECgene alternative splicing isoforms for
PGA3

Expression for PGA3 Gene

mRNA expression in normal human tissues for PGA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGA3 Gene

This gene is overexpressed in Stomach (52.8).

Protein differential expression in normal tissues for PGA3 Gene

This gene is overexpressed in Stomach (58.8) and Urine (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PGA3 Gene

SOURCE GeneReport for Unigene cluster for PGA3 Gene Hs.601055

genes like me logo Genes that share expressions with PGA3: view

Expression partners for PGA3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PGA3 Gene

Orthologs for PGA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PGA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGA5 35
  • 84.72 (n)
  • 82.12 (a)
PGA 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PGA 35
  • 86.18 (n)
  • 82.64 (a)
PGA 36
  • 82 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PGA4 35
  • 98.97 (n)
  • 98.45 (a)
-- 36
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pga5 36
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC395926 35
  • 63.53 (n)
  • 59 (a)
PGA 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pga4 35
  • 68.06 (n)
  • 69.01 (a)
Species with no ortholog for PGA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PGA3 Gene

ENSEMBL:
Gene Tree for PGA3 (if available)
TreeFam:
Gene Tree for PGA3 (if available)

Paralogs for PGA3 Gene

Paralogs for PGA3 Gene

Selected SIMAP similar genes for PGA3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PGA3 Gene

genes like me logo Genes that share paralogs with PGA3: view

Variants for PGA3 Gene

Sequence variations from dbSNP and Humsavar for PGA3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs520677 -- 61,205,441(-) gtcct(C/T)atcat intron-variant
rs582338 -- 61,205,482(+) AACAA(A/G)AAGAT intron-variant
rs589684 -- 61,202,458(-) TGGAG(C/T)GAAGC upstream-variant-2KB
rs595823 -- 61,203,393(-) GCCCT(A/G)AGCCA upstream-variant-2KB
rs656697 -- 61,205,587(-) TTGGC(C/T)GATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGA3 Gene

Variant ID Type Subtype PubMed ID
nsv832176 CNV Gain+Loss 17160897
nsv428259 CNV Gain+Loss 18775914
dgv390e1 CNV Complex 17122850
nsv832177 CNV Loss 17160897
nsv820586 CNV Deletion 20802225
nsv825937 CNV Loss 20364138
nsv8833 CNV Gain 18304495
esv29298 CNV Gain+Loss 19812545
esv1004439 CNV Deletion 20482838
nsv72 CNV Insertion 15895083
nsv338 CNV Insertion 18451855
nsv339 CNV Loss 18451855
nsv436823 CNV Insertion 17901297
nsv514629 CNV Complex 21397061

Relevant External Links for PGA3 Gene

HapMap Linkage Disequilibrium report
PGA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGA3 Gene

Disorders for PGA3 Gene

No disorders were found for PGA3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PGA3 Gene

Publications for PGA3 Gene

  1. Primary structure of human pepsinogen gene. (PMID: 6300126) Sogawa K. … Takahashi K. (J. Biol. Chem. 1983) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Histologic and serum risk markers for noncardia early gastric cancer. (PMID: 15688378) Shiotani A. … Graham D.Y. (Int. J. Cancer 2005) 3
  4. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. (PMID: 17559360) Pimanov S.I. … Voropaev E.V. (J. Gastroenterol. Hepatol. 2008) 3
  5. Serum pepsinogens and risk of esophageal squamous dysplasia. (PMID: 18844222) Kamangar F. … Dawsey S.M. (Int. J. Cancer 2009) 3

Products for PGA3 Gene

Sources for PGA3 Gene

Back to Top

Content