Aliases for PFKP Gene
External Ids for PFKP Gene
Previous GeneCards Identifiers for PFKP Gene
This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
GeneCards Summary for PFKP Gene
PFKP (Phosphofructokinase, Platelet) is a Protein Coding gene. Diseases associated with PFKP include Clear Cell Renal Cell Carcinoma and Glycogen Storage Disease Vii. Among its related pathways are Citrate cycle (TCA cycle) and Deadenylation-dependent mRNA decay. GO annotations related to this gene include protein complex binding and 6-phosphofructokinase activity. An important paralog of this gene is PFKM.
UniProtKB/Swiss-Prot for PFKP Gene
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.