Aliases for PFKP Gene
External Ids for PFKP Gene
Previous GeneCards Identifiers for PFKP Gene
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 126.96.36.199). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
GeneCards Summary for PFKP Gene
PFKP (Phosphofructokinase, Platelet) is a Protein Coding gene. Diseases associated with PFKP include glycogen storage disease vii. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include protein complex binding and 6-phosphofructokinase activity. An important paralog of this gene is PFKL.
UniProtKB/Swiss-Prot for PFKP Gene
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.