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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PFKP Gene

protein-coding GIFtS: 66
GCID: GC10P003109

phosphofructokinase, platelet

Explore 16 diseases affiliated with
PFKP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphofructokinase, Platelet¹ ²		EC 2.7.1.11³ ⁸
PFK-C¹ ² ³		6-Phosphofructokinase Type C²
PFKF¹ ² ³		Phosphofructokinase, Platelet Type²
Phosphofructo-1-Kinase Isozyme C² ³		Phosphohexokinase³
Phosphofructokinase 1² ³		Phosphohexokinase³
6-Phosphofructokinase, Platelet Type² ³		EC 2.7.1⁸

External Ids:	HGNC: 8878¹	Entrez Gene: 5214²	Ensembl: ENSG00000067057⁷	OMIM: 171840⁵	UniProtKB: Q01813³

Export aliases for PFKP gene to outside databases

Previous GC identifers: GC10P003157 GC10P003069 GC10P003063 GC10P003099 GC10P003045

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PFKP:

The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK)

(ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of

fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which

maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM

171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) (PubMed

6451249) determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits

P4, P3L, and P2L2.(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: K6PP_HUMAN, Q01813

Function: Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate

fructose-1,6-bisphosphate (FBP) and ADP

Gene Wiki entry for PFKP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PFKP gene promoter:
E2F-3a E2F-4 E2F-5 Pax-5 Sp1 E2F-2 MZF-1 IRF-2 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PFKP promoter sequence

Search SABiosciences Chromatin IP Primers for PFKP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.3-p15.2 Ensembl cytogenetic band: 10p15.2 HGNC cytogenetic band: 10p15.3-p15.2

PFKP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKP gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P003109: view genomic region (about GC identifiers)

Start:	3,109,712 bp from pter	End:	3,179,904 bp from pter
Size:	70,193 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K6PP_HUMAN, Q01813 (See protein sequence)

Recommended Name: 6-phosphofructokinase type C

Size: 784 amino acids; 85596 Da

Cofactor: Magnesium

Subunit: Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. A subunit composition with a higher

proportion of platelet type subunits is found in platelets, brain and fibroblasts

Miscellaneous: In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet)

isoenzymes

Secondary accessions: Q5VSR8

Explore the universe of human proteins at neXtProt for PFKP: NX_Q01813

Post-translational modifications:

GlcNAcylation decreases enzyme activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01813

4/38 DME Specific Peptides for PFKP (Q01813) (see all 38)

VLTSGGD

ALHRIIE

IIIVAEG

NYTTDFI

PFKP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001229268.1 NP_002618.1

ENSEMBL proteins:

ENSP00000370517 ENSP00000370465 ENSP00000410590 ENSP00000385880 ENSP00000408858

ENSP00000387871 ENSP00000370462 ENSP00000410275

Reactome Protein details: Q01813
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PFKP

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005829	cytosol	TAS	--
GO:0005945	6-phosphofructokinase complex	NAS	--

PFKP for ontologies About GeneDecksing

PFKP Antibody Products:

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Assay Products for PFKP:

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	Uscn ELISAs and CLIAs for PFKP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PFKP for domains About GeneDecksing

4 InterPro domains/families:

IPR009161 6-phosphofructokinase_euk

IPR022953 Phosphofructokinase

IPR015912 Phosphofructokinase_CS

IPR000023 Phosphofructokinase_dom

Graphical View of Domain Structure for InterPro Entry Q01813

ProtoNet protein and cluster: Q01813

1 Blocks protein family: IPB000023 Phosphofructokinase

UniProtKB/Swiss-Prot: K6PP_HUMAN, Q01813

Similarity: Belongs to the phosphofructokinase family. Two domains subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: K6PP_HUMAN, Q01813

Function: Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate

fructose-1,6-bisphosphate (FBP) and ADP

Catalytic activity: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

Enzyme regulation: Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate

Genatlas biochemistry entry for PFKP:

6-phosphofructo-1-kinase,expressed in platelet,fructose metabolism,energy pathway

Enzyme Numbers (IUBMB): EC 2.7.1.11¹ ² EC 2.7.1²

miRNA Products:		OriGene 3'-UTR Clone: PFKP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PFKP
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PFKP (see all 25):
		hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: PFKP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PFKP
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKP

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003872	6-phosphofructokinase activity	TAS	1834056
GO:0005524	ATP binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0070095	fructose-6-phosphate binding	--	--

PFKP for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PFKP:

Decreased circadian period len

Animal Models:
1 MGI phenotypic allele

for Pfkp (no phenotypes)

PFKP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycolysis and gluconeogenesis (short map)

	Glycolysis and gluconeogenesis (short map)	1.00			Glycolysis and Gluconeogenesis	0.60
	Glycolysis and gluconeogenesis (short map)	0.97			Glycolysis / Gluconeogenesis	0.41

Glucose metabolism

Glucose metabolism

1.00

Glycolysis

0.44

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

AMPK Enzyme Complex Pathway

AMPK Enzyme Complex Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PFKP

Glycolysis and gluconeogenesis (short map)

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PFKP

	AMPK Enzyme Complex Pathway
	Akt Signaling

1 Cell Signaling Technology (CST) Pathway for PFKP

Glucose / Energy Metabolism

1 GeneGo (Thomson Reuters) Pathway for PFKP

Glycolysis and gluconeogenesis (short map)

2 BioSystems Pathways for PFKP

	Glycolysis and Gluconeogenesis
	glycolysis I

4 Reactome Pathways for PFKP

	Metabolism of carbohydrates
	Metabolism
	Glucose metabolism
	Glycolysis

5 Kegg Pathways (Kegg details for PFKP):

	Glycolysis / Gluconeogenesis
	Pentose phosphate pathway
	Fructose and mannose metabolism
	Galactose metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: K6PP_HUMAN, Q01813

Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose:

step 3/4

PFKP for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PFKP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/801 Interacting proteins for PFKP (Q01813^{2, 3} ENSP00000370517⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 801)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBA5	Q9GZZ9²^,³	MINT-7945693 MINT-7947479 I2D: score=1
TNFRSF1B	P20333²^,³	MINT-49382 I2D: score=2
PRKAG1	P54619²^,³	MINT-7945693 I2D: score=1
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
HSPD1	P10809², ENSP00000340019⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000340019

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006002	fructose 6-phosphate metabolic process	IEA	--
GO:0006006	glucose metabolic process	TAS	--
GO:0006096	glycolysis	TAS	--
GO:0030388	fructose 1,6-bisphosphate metabolic process	--	--

PFKP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PFKP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PFKP

10/15 HMDB Compounds for PFKP (see all 15) About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Beta-D-Fructose 6-phosphate	beta-D-Fructose 6-phosphate (see all 2)	--	--
CDP	CDP (see all 3)	63-38-7	--
Cytidine triphosphate	cytidine 5'-(tetrahydrogen triphosphate) (see all 15)	65-47-4	--
D-Tagatose 1,6-bisphosphate	1,6-di-O-phosphono-D-tagatofuranose	--	--
D-Tagatose 6-phosphate	6-O-phosphono-D-tagatofuranose (see all 2)	--	--
Fructose 1,6-bisphosphate	D-Fructose 1,6-biphosphate (see all 16)	488-69-7	--
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
IDP	5'-IDP (see all 10)	86-04-4	--

1 Novoseek chemical compound relationship for PFKP gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	23.8	7	16862226 (2), 16051672 (2)

Search CenterWatch for drugs/clinical trials and news about PFKP / K6PP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PFKP gene (2 alternative transcripts):

NM_001242339.1 NM_002627.4

Unigene Cluster for PFKP:

Phosphofructokinase, platelet

Hs.26010 [show with all ESTs]

Unigene Representative Sequence: NM_001242339

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381125(uc001igp.3 uc009xhs.1 uc009xht.3 uc009xhu.3)

ENST00000495715 ENST00000381075(uc001igq.3 uc009xhr.3) ENST00000421751

ENST00000407806 ENST00000415005 ENST00000468050 ENST00000460445 ENST00000413079

ENST00000381072 ENST00000433193

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PFKP
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PFKP (see all 25):
		hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: PFKP 3' UTR sequence

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Additional cDNA sequence:

AK092597.1 AK097692.1 AK291841.1 AK308003.1 AK308226.1 AK309692.1 BC002536.1 BC021698.1

BC029138.1 BC043156.1 D21863.1 D25328.1 M64784.1

24/33 DOTS entries (see all 33):

DT.91770457 DT.100841045 DT.95069913 DT.101985060 DT.121290159 DT.100841029 DT.100841038 DT.121290133

DT.75157960 DT.95069912 DT.219277 DT.91961196 DT.121290185 DT.121290215 DT.121290241 DT.91770458

DT.121290230 DT.91770476 DT.100700696 DT.100841025 DT.100841032 DT.100841044 DT.121290240 DT.121290252

24/690 AceView cDNA sequences (see all 690):

AA406495 AA384565 BM549037 CR603216 CR593800 BG680103 AA228101 BI824634

CB140100 BE255919 BU165380 BI754858 R50429 CD742553 BG257599 BG319605

BQ896627 BM823941 AA311651 BU737488 BQ638920 BM792060 BQ669956 BG057403

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PFKP (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	·	9d	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^
SP1:																	-		-				-						-		-		-
SP2:			-		-						-						-		-				-						-		-		-
SP3:
SP4:																							-						-		-		-
SP5:

ExUns:	21a	·	21b	^	22	^	23	^	24	^	25	^	26a	·	26b	·	26c
SP1:	-
SP2:	-
SP3:	-
SP4:
SP5:

ECgene alternative splicing isoforms for PFKP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PFKP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCAGATG

About this image

PFKP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Eye

Gut Tube

Heart

Presumptive Spinal Cord

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See PFKP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PFKP

SOURCE GeneReport for Unigene cluster: Hs.26010

SABiosciences Expression via Pathway-Focused PCR Array including PFKP:

Hypoxia Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for PFKP gene from 11/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pfkp^{1 , 5}	phosphofructokinase, platelet^{1, 5}	83.33(n)¹ 90.21(a)¹		13 (3.25 cM)⁵ 56421¹ NM_019703.3¹ NP_062677.1¹ 6579768⁵
chicken (Gallus gallus)	Aves	Q5ZHU4_CHICK⁶ PFKM⁶	muscle phosphofructokinase	84(a) 70(a)	1 ↔ 1 possible ortholog	2(11326464-11368023) Un(31513675-31515607)
lizard (Anolis carolinensis)	Reptilia	PFKP⁶	--	84(a)	1 ↔ 1	6(9255502-9302440)
African clawed frog (Xenopus laevis)	Amphibia	MGC68847²	hypothetical protein MGC68847	76.89(n)		BC057710.1
zebrafish (Danio rerio)	Actinopterygii	Dr.12547²	Transcribed sequence with moderate similarity to protein more	74.5(n)		CK016450.1
fruit fly (Drosophila melanogaster)	Insecta	Pfk³	glycolysis 6-phosphofructokinase	53(a)		--
worm (Caenorhabditis elegans)	Secernentea	Y71H10A.1b³	--	57(a) (best of 3)		X(2976190-2979588) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	PFK1¹	Pfk1p	49.12(n) 44.64(a)		853155 NP_011756.1
thale cress (Arabidopsis thaliana)	eudicotyledons	PFK6⁶ PFK7⁶ (see all 11)	6-phosphofructokinase 7 (see all 11)	18(a) 17(a) (see all 11)	possible ortholog possible ortholog (see all 11)	4(15844780-15848441) 5(22923922-22926963)
rice (Oryza sativa)	Liliopsida	-- -- (see all 15)	6-phosphofructokinase, putative, expressed (see all 15)	17(a) 15(a) (see all 15)	possible ortholog possible ortholog (see all 15)	4(23278212-23280588) 6(2677975-2682782)

ENSEMBL Gene Tree for PFKP (if available)
TreeFam Gene Tree for PFKP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PFKP gene

PFKL² PFKM²

6 SIMAP similar genes for PFKP using alignment to 9 protein entries: K6PP_HUMAN (see all proteins):

PFK-P PFKM PFKL DKFZp686G1648 DKFZp686L2097 DKFZp779O048

PFKP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35363509^1,2	C,F,	--	3107745(+)	`AATTGC/TATAAG`	1	--	us2k¹		5		NA	128
rs111783572^1,2		--	3107780(+)	`TAAAAC/TTCAGT`	1	--	us2k¹		1		CSA	2
rs35301243^1,2	C,F,	--	3107796(+)	`CCACCC/TTCTCC`	1	--	us2k¹		5		NA	128
rs138185654^1,2		--	3107856(+)	`TTCTCC/TAGCGC`	1	--	us2k¹		0	--	--	--	--
rs12779561^1,2	C,F,	--	3107896(+)	`GCTTAG/CAGCCT`	1	--	us2k¹		5		NA	128
rs12261307^1,2		--	3107970(+)	`TATTAA/GTAGAA`	1	--	us2k¹ tfbs³		2		CSA WA	120
rs142878876^1,2		--	3108135(+)	`CTGAGG/TACCAA`	1	--	us2k¹		0	--	--	--	--
rs146077102^1,2		--	3108182(+)	`GGAGAG/TATCAG`	1	--	us2k¹		0	--	--	--	--
rs79483948^1,2	C,	--	3108213(+)	`GCAGAG/TTTTTT`	1	--	us2k¹		2		NA	122
rs188460948^1,2		--	3108292(+)	`AAAATC/TCATGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PFKP (3109712 - 3179904 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for PFKP
15/16 CNVs (see all 16): 70907 48523 48513 48521 9137 53717 3789 31708 48522 70905 29852 29582 30471 8637 2842
3 Indels: 24471 44736 70906

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PFKP for disorders           About GeneDecksing

OMIM gene information: 171840    OMIM disorders: --

16 diseases for PFKP:    About MalaCards

glycogen storage disease vii glycogen storage disease pancreatic ductal adenocarcinoma alzheimer's disease

pharyngitis adenocarcinoma breast cancer pancreatitis

obesity pneumonia cholesterol hypoxia

tuberculosis thyroiditis neuronitis mycobacterium tuberculosis

1 Novoseek disease relationship for PFKP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	19260470 (1)

Human Genome Epidemiology (HuGE) Navigator: PFKP (8 documents)

Export disorders for PFKP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PFKP gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with PFKP)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and sequence of a cDNA encoding human platelet phosphofructokinase. (PubMed id 1834056)^{1, 2, 9} Simpson C.J. and Fothergill-Gilmore L.A. (1991)
Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet. (PubMed id 8117307)^{1, 2, 9} Eto K.... Kadowaki T. (1994)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15. (PubMed id 1533608)^{1, 9} Morrison N....Connor J.M. (1992)
Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines. (PubMed id 15716112)^{1, 9} Hannemann A....Bigl M. (2005)
Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2). (PubMed id 12963966)^{1, 9} Mahlknecht U....Bucala R. (2003)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5214	HGNC: 8878	AceView: PFKP	Ensembl:ENSG00000067057	euGenes: HUgn5214
ECgene: PFKP	Kegg: 5214	H-InvDB: PFKP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PFKP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PFKP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PFKP gene:
Search GeneIP for patents involving PFKP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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