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Aliases for PFKP Gene

Aliases for PFKP Gene

  • Phosphofructokinase, Platelet 2 3
  • Phosphofructo-1-Kinase Isozyme C 3 4
  • 6-Phosphofructokinase Type C 3 4
  • Phosphohexokinase 3 4
  • EC 4 63
  • ATP-PFK 3 4
  • PFK-C 3 4
  • PFK-P 3 4
  • PFKF 3 4
  • ATP-Dependent 6-Phosphofructokinase, Platelet Type 3
  • 6-Phosphofructokinase, Platelet Type 3
  • Phosphofructokinase, Platelet Type 3
  • Phosphofructokinase 1 3
  • Phosphofructokinase 2
  • Platelet Type 2
  • EC 2.7.1 63

External Ids for PFKP Gene

Previous GeneCards Identifiers for PFKP Gene

  • GC10P003157
  • GC10P003069
  • GC10P003063
  • GC10P003099
  • GC10P003045
  • GC10P003109

Summaries for PFKP Gene

Entrez Gene Summary for PFKP Gene

  • The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]

GeneCards Summary for PFKP Gene

PFKP (Phosphofructokinase, Platelet) is a Protein Coding gene. Among its related pathways are Akt Signaling and Metabolism. GO annotations related to this gene include 6-phosphofructokinase activity. An important paralog of this gene is PFKL.

UniProtKB/Swiss-Prot for PFKP Gene

  • Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Gene Wiki entry for PFKP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFKP Gene

Genomics for PFKP Gene

Regulatory Elements for PFKP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PFKP Gene

3,066,333 bp from pter
3,137,712 bp from pter
71,380 bases
Plus strand

Genomic View for PFKP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PFKP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PFKP Gene

Proteins for PFKP Gene

  • Protein details for PFKP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent 6-phosphofructokinase, platelet type
    Protein Accession:
    Secondary Accessions:
    • B3KS15
    • Q5VSR7
    • Q5VSR8

    Protein attributes for PFKP Gene

    784 amino acids
    Molecular mass:
    85596 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homo- and heterotetramers. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts
    • In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes

    Alternative splice isoforms for PFKP Gene


neXtProt entry for PFKP Gene

Proteomics data for PFKP Gene at MOPED

Post-translational modifications for PFKP Gene

  • GlcNAcylation decreases enzyme activity.
  • Ubiquitination at Lys15, Lys25, Lys109, Lys139, Lys289, Lys395, Lys400, Lys408, Lys459, Lys480, Lys486, Lys666, Lys688, Lys747, Lys759, and Lys765
  • Glycosylation at Ser540
  • Modification sites at PhosphoSitePlus

Other Protein References for PFKP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PFKP (PFKP)

Domains for PFKP Gene

Protein Domains for PFKP Gene

Graphical View of Domain Structure for InterPro Entry



  • Q01813
  • Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
genes like me logo Genes that share domains with PFKP: view

No data available for Gene Families for PFKP Gene

Function for PFKP Gene

Molecular function for PFKP Gene

GENATLAS Biochemistry:
6-phosphofructo-1-kinase,expressed in platelet,fructose metabolism,energy pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Enzyme Numbers (IUBMB) for PFKP Gene

Gene Ontology (GO) - Molecular Function for PFKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003872 6-phosphofructokinase activity TAS 1834056
GO:0005524 ATP binding IEA --
GO:0032403 protein complex binding IDA 23209302
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PFKP: view

Phenotypes for PFKP Gene

GenomeRNAi human phenotypes for PFKP:
genes like me logo Genes that share phenotypes with PFKP: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PFKP

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PFKP Gene

Localization for PFKP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PFKP Gene


Subcellular locations from

Jensen Localization Image for PFKP Gene COMPARTMENTS Subcellular localization image for PFKP gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PFKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PFKP: view

Pathways for PFKP Gene

genes like me logo Genes that share pathways with PFKP: view

Pathways by source for PFKP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q01813-PFKAP_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Gene Ontology (GO) - Biological Process for PFKP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006002 fructose 6-phosphate metabolic process IEA --
GO:0006006 glucose metabolic process TAS --
GO:0006096 glycolytic process --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PFKP: view

Compounds for PFKP Gene

(15) HMDB Compounds for PFKP Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Not Available
  • CDP
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)

(1) Novoseek inferred chemical compound relationships for PFKP Gene

Compound -log(P) Hits PubMed IDs
glucose 23.8 4
genes like me logo Genes that share compounds with PFKP: view

Transcripts for PFKP Gene

Unigene Clusters for PFKP Gene

Phosphofructokinase, platelet:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PFKP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PFKP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - - - - - - - -
SP4: - - - -
SP7: -

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: -

Relevant External Links for PFKP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PFKP Gene

mRNA expression in normal human tissues for PFKP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PFKP Gene

This gene is overexpressed in Fetal heart (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PFKP Gene

SOURCE GeneReport for Unigene cluster for PFKP Gene Hs.26010

genes like me logo Genes that share expressions with PFKP: view

Expression partners for PFKP Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PFKP Gene

Orthologs for PFKP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PFKP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PFKP 35
  • 84.21 (n)
  • 89.88 (a)
  • 88 (a)
(Canis familiaris)
Mammalia PFKP 35
  • 85.68 (n)
  • 92.97 (a)
  • 90 (a)
(Mus musculus)
Mammalia Pfkp 35
  • 82.56 (n)
  • 88.95 (a)
Pfkp 16
Pfkp 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Pfkp 35
  • 83.12 (n)
  • 88.72 (a)
(Monodelphis domestica)
Mammalia PFKP 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia PFKP 36
  • 81 (a)
(Pan troglodytes)
Mammalia PFKP 36
  • 100 (a)
(Gallus gallus)
Aves PFKP 36
  • 85 (a)
(Anolis carolinensis)
Reptilia PFKP 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75635 35
pfkp 35
  • 73.88 (n)
  • 82.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68847 35
(Danio rerio)
Actinopterygii Dr.12547 35
pfkpb 35
  • 72.72 (n)
  • 81.59 (a)
pfkpa 36
  • 78 (a)
pfkpb 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pfk 37
  • 53 (a)
Pfk 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea C50F4.2 37
  • 40 (a)
Y71H10A.1a 37
  • 56 (a)
Y71H10A.1b 37
  • 57 (a)
pfk-1 36
  • 54 (a)
pfk-2 36
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL208W 35
  • 52.26 (n)
  • 44.7 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05544g 35
  • 50.43 (n)
  • 43.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PFK1 35
  • 49.46 (n)
  • 45.1 (a)
PFK1 36
  • 34 (a)
PFK2 36
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3271 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for PFKP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PFKP Gene

Gene Tree for PFKP (if available)
Gene Tree for PFKP (if available)

Paralogs for PFKP Gene

Paralogs for PFKP Gene

genes like me logo Genes that share paralogs with PFKP: view

Variants for PFKP Gene

Sequence variations from dbSNP and Humsavar for PFKP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs541 -- 3,136,723(-) AGCAC(A/C/G)CACTG utr-variant-3-prime
rs542 -- 3,136,716(-) ACTGG(A/G)GCAGG utr-variant-3-prime
rs543 -- 3,136,673(+) TTATT(A/G)ACATT utr-variant-3-prime
rs7673 -- 3,136,713(+) CCACC(A/T)GCTCC utr-variant-3-prime
rs9063 -- 3,136,623(+) TGTCT(C/G)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PFKP Gene

Variant ID Type Subtype PubMed ID
nsv894751 CNV Gain 21882294
dgv212e1 CNV Complex 17122850
nsv428229 CNV Gain 18775914
nsv517630 CNV Gain+Loss 19592680
esv34832 CNV Gain 17911159
dgv63n27 CNV Gain 19166990
esv26266 CNV Gain+Loss 19812545
nsv470912 CNV Gain 18288195
nsv894753 CNV Gain 21882294
esv2730995 CNV Deletion 23290073
nsv894759 CNV Gain 21882294
nsv894760 CNV Loss 21882294
nsv894761 CNV Gain 21882294
nsv894762 CNV Gain 21882294
nsv470913 CNV Loss 18288195
nsv825215 CNV Gain 20364138
dgv593n71 CNV Loss 21882294
nsv8595 CNV Gain 18304495
esv2731128 CNV Deletion 23290073
esv2674301 CNV Deletion 23128226
nsv507530 CNV Insertion 20534489
esv2731140 CNV Deletion 23290073
esv2731151 CNV Deletion 23290073
esv1312745 CNV Deletion 17803354
dgv594n71 CNV Loss 21882294
nsv894767 CNV Gain 21882294
dgv595n71 CNV Loss 21882294
nsv894770 CNV Gain 21882294
esv2750891 CNV Loss 17911159
esv2731162 CNV Deletion 23290073
esv2731173 CNV Deletion 23290073
nsv516811 CNV Loss 19592680
dgv596n71 CNV Loss 21882294
dgv597n71 CNV Loss 21882294
nsv894776 CNV Loss 21882294
dgv97e201 CNV Deletion 23290073
dgv98e201 CNV Deletion 23290073
dgv99e201 CNV Deletion 23290073
esv2403236 CNV Deletion 18987734
esv2731262 CNV Deletion 23290073
esv2731273 CNV Deletion 23290073
nsv894777 CNV Loss 21882294
nsv894778 CNV Loss 21882294
nsv894779 CNV Loss 21882294
esv28525 CNV Loss 19812545
nsv8596 CNV Loss 18304495
nsv516917 CNV Loss 19592680
nsv525229 CNV Loss 19592680

Relevant External Links for PFKP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFKP Gene

Disorders for PFKP Gene

(1) Novoseek inferred disease relationships for PFKP Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for PFKP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PFKP: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PFKP Gene

Publications for PFKP Gene

  1. Isolation and sequence of a cDNA encoding human platelet phosphofructokinase. (PMID: 1834056) Simpson C.J. … Fothergill-Gilmore L.A. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  2. Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet. (PMID: 8117307) Eto K. … Kadowaki T. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2). (PMID: 12963966) Mahlknecht U. … Bucala R. (Int. J. Oncol. 2003) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines. (PMID: 15716112) Hannemann A. … Bigl M. (Gene 2005) 3 23

Products for PFKP Gene

  • Addgene plasmids for PFKP

Sources for PFKP Gene

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