Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PFKM Gene

protein-coding   GIFtS: 73
GCID: GC12P048501

Phosphofructokinase, Muscle

(Previous names: phosphofructokinase, polypeptide X)
(Previous symbol: PFKX)
  See PFKM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phosphofructokinase, Muscle1 2     6-Phosphofructokinase, Muscle Type2
PFKX1 2 3     PFK-12
Phosphofructokinase, Polypeptide X1 2     PFK12
Phosphofructo-1-Kinase Isozyme A2 3     PFKA2
Phosphofructokinase 12 3     phosphofructokinase-M2
PFK-A2 3     phosphohexokinase2
EC 2.7.1.113 8     Phosphofructokinase-M3
GSD72 5     Phosphohexokinase3
6-phosphofructo-1-kinase2     EC 2.7.18

External Ids:    HGNC: 88771   Entrez Gene: 52132   Ensembl: ENSG000001525567   OMIM: 6106815   UniProtKB: P082373   

Export aliases for PFKM gene to outside databases

Previous GC identifers: GC12P048525 GC12P048412 GC12P048229 GC12P046802 GC12P046788 GC12P046785 GC12P045531


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PFKM Gene:
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as
subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of
fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This
gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease
type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.(provided by
RefSeq, Nov 2009)

GeneCards Summary for PFKM Gene:
PFKM (phosphofructokinase, muscle) is a protein-coding gene. Diseases associated with PFKM include glycogen storage disease vii, and phosphoglycerate kinase deficiency. GO annotations related to this gene include kinase binding and identical protein binding. An important paralog of this gene is PFKP.

UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237
Function: Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to
generate fructose-1,6-bisphosphate (FBP) and ADP

Gene Wiki entry for PFKM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PFKM gene promoter:
         HOXA9B   HOXA9   AP-1   ATF-2   FOXD1   CUTL1   STAT5A   c-Jun   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PFKM promoter sequence
   Search Chromatin IP Primers for PFKM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PFKM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.11

PFKM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKM gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P048501:  view genomic region     (about GC identifiers)

Start:
48,498,922 bp from pter      End:
48,540,187 bp from pter
Size:
41,266 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237 (See protein sequence)
Recommended Name: 6-phosphofructokinase, muscle type  
Size: 780 amino acids; 85183 Da
Cofactor: Magnesium
Subunit: Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3
Miscellaneous: In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP
(platelet) isoenzymes
Secondary accessions: J3KNX3 Q16814 Q16815 Q6ZTT1
Alternative splicing: 3 isoforms:  P08237-1   P08237-2   P08237-3   (No experimental confirmation available. Ref.4 (BAC86498) sequence is in conflict in position: 2:H->L)

Explore the universe of human proteins at neXtProt for PFKM: NX_P08237

Explore proteomics data for PFKM at MOPED

Post-translational modifications: 

  • GlcNAcylation decreases enzyme activity (By similarity)1
  • Ubiquitination2 at Lys738
  • Glycosylation2 at Ser530
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PFKM (P08237) (see all 44)
     HAHLEHI  RVTVLGH  VLTSGGD  TLGIGKA 


    See PFKM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000280.1  NP_001160158.1  NP_001160159.1  NP_001160160.1  

    ENSEMBL proteins: 
     ENSP00000450369   ENSP00000449835   ENSP00000446945   ENSP00000446829   ENSP00000447997  
     ENSP00000345771   ENSP00000447992   ENSP00000450173   ENSP00000449622   ENSP00000448940  
     ENSP00000448018   ENSP00000352842   ENSP00000448318   ENSP00000447774   ENSP00000448315  
     ENSP00000448253   ENSP00000449269   ENSP00000448177   ENSP00000446805   ENSP00000449426  
     ENSP00000446519   ENSP00000446740   ENSP00000450091   ENSP00000378656   ENSP00000309438  
    Reactome Protein details: P08237

    PFKM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PFKM
    OriGene Protein Over-expression Lysate for PFKM
    OriGene MassSpec for PFKM
    OriGene Custom Protein Services for PFKM
    GenScript Custom Purified and Recombinant Proteins Services for PFKM
    Novus Biologicals PFKM Proteins
    Novus Biologicals PFKM Lysates
    Sino Biological Recombinant Protein for PFKM
    Sino Biological Cell Lysate for PFKM
    ProSpec Recombinant Protein for PFKM
    Cloud-Clone Corp. Proteins for PFKM

     
    Search eBioscience for Proteins for PFKM 

     
    antibodies-online proteins for PFKM (21 products) 

     
    antibodies-online peptides for PFKM

    PFKM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PFKM
    R&D Systems Antibodies for PFKM (Muscle Phosphofructokinase/PFKM)
    OriGene Antibodies for PFKM
    OriGene Custom Antibody Services for PFKM
    Novus Biologicals PFKM Antibodies
    Abcam antibodies for PFKM
    Cloud-Clone Corp. Antibodies for PFKM
    ThermoFisher Antibody for PFKM
    antibodies-online antibodies for PFKM (74 products) 

    PFKM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PFKM
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PFKM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PFKM
    Cloud-Clone Corp. CLIAs for PFKM
    Search eBioscience for ELISAs for PFKM 
    antibodies-online kits for PFKM (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR009161 6-phosphofructokinase_euk
     IPR022953 Phosphofructokinase
     IPR015912 Phosphofructokinase_CS
     IPR000023 Phosphofructokinase_dom

    Graphical View of Domain Structure for InterPro Entry P08237

    ProtoNet protein and cluster: P08237

    1 Blocks protein domain: IPB000023 Phosphofructokinase

    UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237
    Similarity: Belongs to the phosphofructokinase family. Two domains subfamily


    Find genes that share domains with PFKM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K6PF_HUMAN, P08237
    Function: Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to
    generate fructose-1,6-bisphosphate (FBP) and ADP
    Catalytic activity: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
    Enzyme regulation: Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or
    citrate

         Genatlas biochemistry entry for PFKM:
    6-phosphofructo-1-kinase,expressed in muscle,previously assigned to chr 1,fructose metabolism,energy pathway

         Enzyme Numbers (IUBMB): EC 2.7.1.111 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038726-phosphofructokinase activity ISS--
    GO:0005515protein binding IPI12649290
    GO:0005524ATP binding IDA8780720
    GO:0008022protein C-terminus binding IPI12649290
    GO:0008443phosphofructokinase activity ----
         
    Find genes that share ontologies with PFKM           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PFKM:
     Actin fiber cells  Decreased 12E8 tau but not tot  Increased apoptosis  Upregulation of Wnt/beta-caten 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pfkm):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle 

    Find genes that share phenotypes with PFKM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pfkmtm1Fbos for PFKM

       genOway: Develop your customized and physiologically relevant rodent model for PFKM

    miRNA
    Products:
        
    miRTarBase miRNAs that target PFKM:
    hsa-mir-92a-3p (MIRT049227), hsa-mir-320a (MIRT044562), hsa-let-7b-5p (MIRT052269)

    Block miRNA regulation of human, mouse, rat PFKM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PFKM (see all 24):
    hsa-miR-320a hsa-miR-128 hsa-miR-3133 hsa-miR-3916 hsa-miR-3125 hsa-miR-320e hsa-miR-591 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidPFKM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PFKM
    Predesigned siRNA for gene silencing in human, mouse, rat PFKM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PFKM

    Clone
    Products:
         
    OriGene clones in human, mouse for PFKM (see all 22)
    OriGene ORF clones in mouse, rat for PFKM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PFKM (NM_001166686)
    Sino Biological Human cDNA Clone for PFKM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PFKM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKM
    Addgene plasmids for PFKM 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PFKM
    Browse ESI BIO Cell Lines and PureStem Progenitors for PFKM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKM

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12353) for PFKM 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    chloroplast2
    cytoskeleton2
    extracellular2
    mitochondrion2
    nucleus2
    peroxisome2
    endoplasmic reticulum1
    lysosome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:00059456-phosphofructokinase complex IDA6444532
    GO:0016324apical plasma membrane IDA12649290

    Find genes that share ontologies with PFKM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PFKM About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and gluconeogenesis short map 0.60
    Glycolysis0.40
    Glycolysis and Gluconeogenesis0.60
    glycolysis0.00
    Glycolysis / Gluconeogenesis0.46
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Carbon metabolism
    Carbon metabolism0.38
    Biosynthesis of amino acids0.38
    4Akt Signaling
    Akt Signaling0.60
    5MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45


    Find genes that share SuperPaths with PFKM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PFKM
        AMPK Enzyme Complex Pathway
    Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for PFKM
        Glycolysis and gluconeogenesis (short map)

    5 BioSystems Pathways for PFKM
        Insulin Signaling
    Glycolysis and Gluconeogenesis
    glycolysis
    Validated targets of C-MYC transcriptional activation
    conversion of glucose to acetyl CoA and entry into the TCA cycle


    1 Reactome Pathway for PFKM
        Glycolysis


    Selected Kegg Pathways  (Kegg details for PFKM) (see all 7):
        Glycolysis / Gluconeogenesis
    Pentose phosphate pathway
    Fructose and mannose metabolism
    Galactose metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237
    Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from
    D-glucose: step 3/4

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PFKM
    Interactions:

        GeneGlobe Interaction Network for PFKM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PFKM (P082371, 2, 3 ENSP000003528424) via UniProtKB, MINT, STRING, and/or I2D (see all 863)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=1 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=1 STRING: ENSP00000291295
    PFKLP178581, 3, ENSP000002698484EBI-514788,EBI-487243 I2D: score=4 STRING: ENSP00000269848
    SUMO1P631652, 3, ENSP000003760764MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006002fructose 6-phosphate metabolic process IMP6444532
    GO:0006006glucose metabolic process TAS--
    GO:0006096glycolytic process TAS--
    GO:0032024positive regulation of insulin secretion IEA--

    Find genes that share ontologies with PFKM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PFKM (K6PF)

    Selected HMDB Compounds for PFKM (see all 16)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    D-Tagatose 1,6-bisphosphate1,6-di-O-phosphono-D-tagatofuranose ----
    D-Tagatose 6-phosphate6-O-phosphono-D-tagatofuranose (see all 2)----
    Fructose 1,6-bisphosphateD-Fructose 1,6-biphosphate (see all 16)488-69-7--
    Fructose 6-phosphateD-Fructose 6-phosphate (see all 13)643-13-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    Selected Novoseek inferred chemical compound relationships for PFKM gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 59.1 6 14718702 (1), 10438462 (1), 7603532 (1), 1826293 (1) (see all 6)
    phosphocreatine 36.4 1 9829278 (1)
    carnitine 22.6 2 1826293 (1), 12149506 (1)
    atp 20.9 1 10438462 (1)
    lactate 20.2 3 8482676 (1), 12149506 (1)
    pyruvate 19.7 1 10438462 (1)
    glucose 19.4 10 14718702 (1), 7603532 (1), 12217956 (1), 8764833 (1) (see all 9)
    creatinine 10.2 1 10438462 (1)
    alanine 4.69 1 19218242 (1)
    lipid 0 1 7603532 (1)



    Find genes that share compounds with PFKM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PFKM gene (4 alternative transcripts): 
    NM_000289.5  NM_001166686.1  NM_001166687.1  NM_001166688.1  

    Unigene Cluster for PFKM:

    Phosphofructokinase, muscle
    Hs.75160  [show with all ESTs]
    Unigene Representative Sequence: AK126020
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000550345 ENST00000549003 ENST00000550924 ENST00000549941 ENST00000550257
    ENST00000340802(uc001rrb.2) ENST00000547581(uc001rra.2) ENST00000546755
    ENST00000549366 ENST00000552792 ENST00000548288 ENST00000359794 ENST00000547066
    ENST00000546964(uc001rrd.3) ENST00000548720 ENST00000552989 ENST00000551548
    ENST00000551485
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PFKM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PFKM (see all 24):
    hsa-miR-320a hsa-miR-128 hsa-miR-3133 hsa-miR-3916 hsa-miR-3125 hsa-miR-320e hsa-miR-591 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidPFKM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PFKM
    Predesigned siRNA for gene silencing in human, mouse, rat PFKM
    Clone
    Products:
         
    OriGene clones in human, mouse for PFKM (see all 22)
    OriGene ORF clones in mouse, rat for PFKM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PFKM (NM_001166686)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PFKM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKM
    Addgene plasmids for PFKM 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PFKM
    OriGene qSTAR qPCR primer pairs in human, mouse for PFKM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PFKM
      QuantiTect SYBR Green Assays in human, mouse, rat PFKM
      QuantiFast Probe-based Assays in human, mouse, rat PFKM
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12353) for PFKM 

    Additional mRNA sequence: 

    AK126020.1 AK126229.1 AK303681.1 AK308185.1 AK312284.1 BC000534.2 BC007798.2 BC012799.2 
    BC013298.2 BC021203.2 CR541698.1 D21861.1 J05533.1 M26066.1 U24183.1 Y00698.1 

    Selected DOTS entries (see all 35):

    DT.95200400  DT.100821887  DT.453195  DT.95227048  DT.100821891  DT.95227047  DT.100821889  DT.451936 
    DT.102830750  DT.101968062  DT.100821888  DT.121130909  DT.95239472  DT.100821896  DT.101968583  DT.121130726 
    DT.121130748  DT.91766939  DT.91766943  DT.95227041  DT.95227049  DT.100774897  DT.100821892  DT.102830751 

    Selected AceView cDNA sequences (see all 459):

    BM707870 BQ073492 BQ214726 AI370819 AI193636 BE887098 BE794437 BQ073813 
    BM710783 AV707835 BU732958 BQ425020 Y00698 BM771640 AA152157 AW411025 
    BC021203 AL534236 BQ640633 AU123936 AK126020 AL045056 BQ639191 BU178090 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PFKM (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
    SP1:                                                              -     -     -     -     -     -                                               -     -         
    SP2:                                                              -     -     -     -     -     -                                               -     -         
    SP3:                                                                                                                                            -     -         
    SP4:        -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                               -     -         
    SP5:                                                              -     -     -     -     -     -                                         -     -     -     -   

    ExUns: 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^
    SP1:                                                                          -                       -                                                         
    SP2:                                                                          -                       -                                                         
    SP3:                                                                    -     -                       -                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 31 ^ 32
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for PFKM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PFKM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTCTGCCC
    PFKM Expression
    About this image


    PFKM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
     
     Testis (Reproductive System)
     
     Adrenal Gland (Endocrine System)
     
     Skeletal Muscle (Muscoskeletal System)
    PFKM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PFKM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75160
        Custom PCR Arrays for PFKM
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PFKM
    OriGene qSTAR qPCR primer pairs in human, mouse for PFKM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PFKM
    QuantiTect SYBR Green Assays in human, mouse, rat PFKM
    QuantiFast Probe-based Assays in human, mouse, rat PFKM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PFKM gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pfkm1 , 5 phosphofructokinase, muscle1, 5 90.17(n)1
    97.82(a)1
      15 (54.09 cM)5
    186421  NM_021514.41  NP_067489.31 
     980925895 
    chicken
    (Gallus gallus)
    Aves PFKM1 phosphofructokinase, muscle 75.89(n)
    83.97(a)
      374064  NM_204223.1  NP_989554.2 
    lizard
    (Anolis carolinensis)
    Reptilia PFKM6
    phosphofructokinase, muscle
    85(a)
    1 ↔ 1
    GL343536.1(124076-178939)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045100.12   -- 75.32(n)    BC045100.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pfkma1 phosphofructokinase, muscle a 71.74(n)
    79.79(a)
      447836  NM_001004575.1  NP_001004575.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pfk1 , 3 glycolysis 6-phosphofructokinase3
    Phosphofructokinase1
    54(a)3
    60.91(n)1
    60.86(a)1
      360601  NM_165747.41  NP_724891.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H10A.1a3
    Y71H10A.11
    phosphofructokinase3
    Y71H10A.11
    56(a)
    (best of 3)3
    57.07(n)1
    56.76(a)1
      X(2976190-2980515)3
    1805831  NM_171643.31  NP_741738.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PFK26
    PFK16
    Beta subunit of heterooctameric phosphofructokinas...
    Alpha subunit of heterooctameric phosphofructokina...
    34(a)
    34(a)
    many ↔ many
    many ↔ many
    XIII(671887-674766) YMR205C
    VII(970771-973734) YGR240C


    ENSEMBL Gene Tree for PFKM (if available)
    TreeFam Gene Tree for PFKM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PFKM gene
    PFKP2  PFKL2  
    13 SIMAP similar genes for PFKM using alignment to 23 protein entries:     K6PF_HUMAN (see all proteins):
    DKFZp779O048    PKP2    PFKP    FLT3LG    PFK-P    DKFZp686L2097
    GART    DKFZp686G1648    PS1TP6    PFKL    DKFZp666K083    PHACTR1
    PPARD

    Find genes that share paralogs with PFKM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PFKM (see all 932)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22285001,2,,4
    C,F,O,HGlycogen storage disease 7 (GSD7)4 --48359745(+) ACTCCG/AAGCTG 8 /Q /R mis1 ese338Minor allele frequency- A:0.18MN EA NA NS CSA WA EU 11438
    rs412919711,2,,4
    C,FGlycogen storage disease 7 (GSD7)4 --48371939(+) TTACCG/ATAATG 8 /H /R mis15Minor allele frequency- A:0.01NA EU 5997
    VAR_0060674
    Glycogen storage disease 7 (GSD7)4--see VAR_0060672 D A mis40--------
    VAR_0060634
    Glycogen storage disease 7 (GSD7)4--see VAR_0060632 R L mis40--------
    VAR_0060664
    Glycogen storage disease 7 (GSD7)4--see VAR_0060662 G D mis40--------
    VAR_0060684
    Glycogen storage disease 7 (GSD7)4--see VAR_0060682 W C mis40--------
    VAR_0060644
    Glycogen storage disease 7 (GSD7)4--see VAR_0060642 R P mis40--------
    rs1219181931,2
    Cpathogenic148357209(+) GGTTCA/C/G/
            
    AGTTG
    12 P R L mis10--------
    rs1808924061,2
    --45529160(+) ACCCCA/GCATTT 1 -- us2k10--------
    rs1455948571,2
    --48330661(+) TGTCTA/GGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PFKM (48498922 - 48540187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PFKM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508673CNV Loss20534489
    nsv8971CNV Gain+Loss18304495
    dgv509e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): PFKM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PFKM
    DNA2.0 Custom Variant and Variant Library Synthesis for PFKM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610681   
    OMIM disorders: 232800  
    UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237
  • Glycogen storage disease 7 (GSD7) [MIM:232800]: A metabolic disorder characterized by exercise
    intolerance with associated nausea and vomiting, muscle cramping, exertional myopathy and compensated hemolysis.
    Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after
    vigorous exercise. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for PFKM:    
    About MalaCards
    glycogen storage disease vii    phosphoglycerate kinase deficiency    tularemia    hyperuricemia

    3 diseases from the University of Copenhagen DISEASES database for PFKM:
    Glycogen storage disease     Myopathy     Diabetes mellitus

    Find genes that share disorders with PFKM           About GenesLikeMe

    9 Novoseek inferred disease relationships for PFKM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphofructokinase deficiency 98.8 60 1824792 (4), 14718702 (3), 17608317 (3), 8659544 (2) (see all 29)
    mcardles disease 84.9 8 14718702 (1), 10809925 (1), 9541495 (1), 2018547 (1) (see all 5)
    myopathy 67.5 5 8659544 (1), 7479776 (1), 7825568 (1), 1394261 (1) (see all 5)
    hemolysis 54.9 4 8785459 (2), 7603526 (1), 7550225 (1)
    hyperuricemia 53 1 1838230 (1)
    mitochondrial diseases 34.9 1 7603532 (1)
    down syndrome 21.4 2 15793789 (1)
    acidosis 17.2 1 9541495 (1)
    niddm 0 4 8661033 (1)

    Genetic Association Database (GAD): PFKM
    Human Genome Epidemiology (HuGE) Navigator: PFKM (4 documents)

    Export disorders for PFKM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PFKM gene, integrated from 10 sources (see all 128):
    (articles sorted by number of sources associating them with PFKM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel mutations in non-Ashkenazi Italian patients with muscle phosphofructokinase deficiency. (PubMed id 7513946)1, 2, 9 Tsujino S.... DiMauro S. (Am. J. Hum. Genet. 1994)
    2. Nonsense mutation in the phosphofructokinase muscle subunit gene associated with retention of intron 10 in one of the isolated transcripts in Ashkenazi Jewish patients with Tarui disease. (PubMed id 7479776)1, 4, 9 Vasconcelos O.... Goldfarb L.G. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    3. Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency. (PubMed id 7825568)1, 2, 9 Raben N....Heinisch J.J. (Am. J. Hum. Genet. 1995)
    4. Mutations in muscle phosphofructokinase gene. (PubMed id 7550225)1, 2, 9 Raben N. and Sherman J.B. (Hum. Mutat. 1995)
    5. Structure of the entire human muscle phosphofructokinase-encoding gene: a two-promoter system. (PubMed id 1833270)1, 2, 9 Yamasaki T.... Tarui S. (Gene 1991)
    6. Alternative splicing of the transcript encoding the human muscle isoenzyme of phosphofructokinase. (PubMed id 2140567)1, 2, 9 Sharma P.M.... McLachlan A. (J. Biol. Chem. 1990)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    10. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5213 HGNC: 8877 AceView: PFKM Ensembl:ENSG00000152556 euGenes: HUgn5213
    ECgene: PFKM Kegg: 5213 H-InvDB: PFKM

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PFKM Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PFKM[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PFKM gene:
    Search GeneIP for patents involving PFKM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PFKM
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for PFKM (Muscle Phosphofructokinase/PFKM)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PFKM   OriGene RNAi products in human, mouse, rat for PFKM  
     OriGene qPCR primer pairs and template standards for PFKM   OriGene Protein Over-expression Lysate for PFKM  
     OriGene MassSpec for PFKM   OriGene clones in human, mouse for PFKM  
     OriGene qSTAR qPCR primer pairs in human, mouse for PFKM   OriGene Purified Protein for PFKM  
     OriGene ORF clones in mouse, rat for PFKM   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PFKM   OriGene Custom Protein Services for PFKM  

     
     
     Block miRNA regulation of human, mouse, rat PFKM using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PFKM
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PFKM Predesigned siRNA for gene silencing in human, mouse, rat PFKM
     QuantiFast Probe-based Assays in human, mouse, rat PFKM QuantiTect SYBR Green Assays in human, mouse, rat PFKM
     Custom PCR Arrays for PFKM Search Chromatin IP Primers for PFKM
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PFKM  GeneGlobe Interaction Network for PFKM
     Regulatory tfbs in PFKM promoter
     GenScript Custom Purified and Recombinant Proteins Services for PFKM GenScript cDNA clones with any tag delivered in your preferred vector for PFKM
     GenScript Custom Assay Services for PFKM GenScript Custom overexpressing Cell Line Services for PFKM
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PFKM (K6PF)
     Proteins for PFKM
     Cell Lysates for PFKM
     cDNA Clones for PFKM
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PFKM antibodies
     PFKM proteins
     PFKM lysates
     Antibodies for PFKM
     See all of Abcam's Antibodies, Kits and Proteins for PFKM
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PFKM
     Proteins for PFKM
     Antibodies for PFKM
     ELISAs for PFKM
     CLIAs for PFKM



     Browse ESI BIO Cell Lines and PureStem Progenitors for PFKM
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKM
     SwitchGear 3'UTR luciferase reporter plasmids for PFKM
     SwitchGear Promoter luciferase reporter plasmids for PFKM
     ThermoFisher Antibody for PFKM
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKM
     Browse compounds at ApexBio
     Addgene plasmids for PFKM
      Search eBioscience for proteins for PFKM
      Search eBioscience for elisas for PFKM
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PFKM
     antibodies-online antibodies for PFKM (74 products)
     antibodies-online kits for PFKM (23 products)
     antibodies-online peptides for PFKM
     antibodies-online proteins for PFKM (21 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PFKM gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4