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PFKM Gene

protein-coding   GIFtS: 73
GCID: GC12P048501

Phosphofructokinase, Muscle

(Previous names: phosphofructokinase, polypeptide X)
(Previous symbol: PFKX)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphofructokinase, Muscle1 2     6-Phosphofructokinase, Muscle Type2
PFKX1 2 3     PFK-12
Phosphofructokinase, Polypeptide X1 2     PFK12
Phosphofructo-1-Kinase Isozyme A2 3     PFKA2
Phosphofructokinase 12 3     phosphofructokinase-M2
PFK-A2 3     phosphohexokinase2
EC 2.7.1.113 8     Phosphofructokinase-M3
GSD72 5     Phosphohexokinase3
6-phosphofructo-1-kinase2     EC 2.7.18

External Ids:    HGNC: 88771   Entrez Gene: 52132   Ensembl: ENSG000001525567   OMIM: 6106815   UniProtKB: P082373   

Export aliases for PFKM gene to outside databases

Previous GC identifers: GC12P048525 GC12P048412 GC12P048229 GC12P046802 GC12P046788 GC12P046785 GC12P045531


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PFKM Gene:
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as
subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of
fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This
gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease
type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.(provided by
RefSeq, Nov 2009)

GeneCards Summary for PFKM Gene:
PFKM (phosphofructokinase, muscle) is a protein-coding gene. Diseases associated with PFKM include glycogen storage disease vii, and phosphoglycerate kinase deficiency. GO annotations related to this gene include kinase binding and identical protein binding. An important paralog of this gene is PFKP.

UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237
Function: Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to
generate fructose-1,6-bisphosphate (FBP) and ADP

Gene Wiki entry for PFKM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PFKM gene promoter:
         HOXA9B   HOXA9   AP-1   ATF-2   FOXD1   CUTL1   STAT5A   c-Jun   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PFKM promoter sequence
   Search Chromatin IP Primers for PFKM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PFKM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.11

PFKM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKM gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P048501:  view genomic region     (about GC identifiers)

Start:
48,498,922 bp from pter      End:
48,540,187 bp from pter
Size:
41,266 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237 (See protein sequence)
Recommended Name: 6-phosphofructokinase, muscle type  
Size: 780 amino acids; 85183 Da
Cofactor: Magnesium
Subunit: Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3
Miscellaneous: In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP
(platelet) isoenzymes
Secondary accessions: J3KNX3 Q16814 Q16815 Q6ZTT1
Alternative splicing: 3 isoforms:  P08237-1   P08237-2   P08237-3   (No experimental confirmation available. Ref.4 (BAC86498) sequence is in conflict in position: 2:H->L)

Explore the universe of human proteins at neXtProt for PFKM: NX_P08237

Explore proteomics data for PFKM at MOPED

Post-translational modifications: 

  • GlcNAcylation decreases enzyme activity (By similarity)1
  • Ubiquitination2 at Lys738
  • Glycosylation2 at Ser530
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PFKM (P08237) (see all 44)
     HAHLEHI  RVTVLGH  VLTSGGD  TLGIGKA 


    See PFKM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000280.1  NP_001160158.1  NP_001160159.1  NP_001160160.1  

    ENSEMBL proteins: 
     ENSP00000450369   ENSP00000449835   ENSP00000446945   ENSP00000446829   ENSP00000447997  
     ENSP00000345771   ENSP00000447992   ENSP00000450173   ENSP00000449622   ENSP00000448940  
     ENSP00000448018   ENSP00000352842   ENSP00000448318   ENSP00000447774   ENSP00000448315  
     ENSP00000448253   ENSP00000449269   ENSP00000448177   ENSP00000446805   ENSP00000449426  
     ENSP00000446519   ENSP00000446740   ENSP00000450091   ENSP00000378656   ENSP00000309438  
    Reactome Protein details: P08237

    PFKM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PFKM
    OriGene Protein Over-expression Lysate for PFKM
    OriGene MassSpec for PFKM
    OriGene Custom Protein Services for PFKM
    GenScript Custom Purified and Recombinant Proteins Services for PFKM
    Novus Biologicals PFKM Proteins
    Novus Biologicals PFKM Lysates
    Sino Biological Recombinant Protein for PFKM
    Sino Biological Cell Lysate for PFKM
    ProSpec Recombinant Protein for PFKM
    Cloud-Clone Corp. Proteins for PFKM

    PFKM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PFKM
    R&D Systems Antibodies for PFKM (Muscle Phosphofructokinase/PFKM)
    OriGene Antibodies for PFKM
    OriGene Custom Antibody Services for PFKM
    Novus Biologicals PFKM Antibodies
    Abcam antibodies for PFKM
    Cloud-Clone Corp. Antibodies for PFKM
    ThermoFisher Antibody for PFKM
    LSBio Antibodies in human, mouse, rat for PFKM

    PFKM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PFKM
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PFKM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PFKM
    Cloud-Clone Corp. CLIAs for PFKM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR009161 6-phosphofructokinase_euk
     IPR022953 Phosphofructokinase
     IPR015912 Phosphofructokinase_CS
     IPR000023 Phosphofructokinase_dom

    Graphical View of Domain Structure for InterPro Entry P08237

    ProtoNet protein and cluster: P08237

    1 Blocks protein domain: IPB000023 Phosphofructokinase

    UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237
    Similarity: Belongs to the phosphofructokinase family. Two domains subfamily


    PFKM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K6PF_HUMAN, P08237
    Function: Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to
    generate fructose-1,6-bisphosphate (FBP) and ADP
    Catalytic activity: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
    Enzyme regulation: Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or
    citrate

         Genatlas biochemistry entry for PFKM:
    6-phosphofructo-1-kinase,expressed in muscle,previously assigned to chr 1,fructose metabolism,energy pathway

         Enzyme Numbers (IUBMB): EC 2.7.1.111 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038726-phosphofructokinase activity ISS--
    GO:0005515protein binding IPI12649290
    GO:0005524ATP binding IDA8780720
    GO:0008022protein C-terminus binding IPI12649290
    GO:0008443phosphofructokinase activity ----
         
    PFKM for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PFKM:
     Actin fiber cells  Decreased 12E8 tau but not tot  Increased apoptosis  Upregulation of Wnt/beta-caten 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pfkm):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle 

    PFKM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pfkmtm1Fbos for PFKM

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PFKM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PFKM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PFKM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PFKM

    miRNA
    Products:
        
    miRTarBase miRNAs that target PFKM:
    hsa-mir-92a-3p (MIRT049227), hsa-mir-320a (MIRT044562), hsa-let-7b-5p (MIRT052269)

    Block miRNA regulation of human, mouse, rat PFKM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PFKM (see all 24):
    hsa-miR-320a hsa-miR-128 hsa-miR-3133 hsa-miR-3916 hsa-miR-3125 hsa-miR-320e hsa-miR-591 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidPFKM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PFKM
    Predesigned siRNA for gene silencing in human, mouse, rat PFKM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PFKM

    Clone
    Products:
         
    OriGene clones in human, mouse for PFKM (see all 22)
    OriGene ORF clones in mouse, rat for PFKM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PFKM (NM_001166686)
    Sino Biological Human cDNA Clone for PFKM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PFKM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKM

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PFKM
    Browse ESI BIO Cell Lines and PureStem Progenitors for PFKM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    chloroplast2
    cytoskeleton2
    extracellular2
    mitochondrion2
    nucleus2
    peroxisome2
    endoplasmic reticulum1
    lysosome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:00059456-phosphofructokinase complex IDA6444532
    GO:0016324apical plasma membrane IDA12649290

    PFKM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PFKM About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and gluconeogenesis short map 0.60
    Glycolysis0.40
    Glycolysis and Gluconeogenesis0.60
    glycolysis0.00
    Glycolysis / Gluconeogenesis0.46
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Carbon metabolism
    Carbon metabolism0.38
    Biosynthesis of amino acids0.38
    4Akt Signaling
    Akt Signaling0.60
    5MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PFKM
        AMPK Enzyme Complex Pathway
    Akt Signaling

    1 GeneGo (Thomson Reuters) Pathway for PFKM
        Glycolysis and gluconeogenesis (short map)

    5 BioSystems Pathways for PFKM
        Insulin Signaling
    Glycolysis and Gluconeogenesis
    glycolysis
    Validated targets of C-MYC transcriptional activation
    conversion of glucose to acetyl CoA and entry into the TCA cycle


    1 Reactome Pathway for PFKM
        Glycolysis


    Selected Kegg Pathways  (Kegg details for PFKM) (see all 7):
        Glycolysis / Gluconeogenesis
    Pentose phosphate pathway
    Fructose and mannose metabolism
    Galactose metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237
    Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from
    D-glucose: step 3/4


    PFKM for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PFKM
    Interactions:

        GeneGlobe Interaction Network for PFKM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PFKM (P082371, 2, 3 ENSP000003528424) via UniProtKB, MINT, STRING, and/or I2D (see all 863) (see top 5)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=1 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=1 STRING: ENSP00000291295
    PFKLP178581, 3, ENSP000002698484EBI-514788,EBI-487243 I2D: score=4 STRING: ENSP00000269848
    SUMO1P631652, 3, ENSP000003760764MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    TUBGCP3Q96CW52, ENSP000002619654MINT-7945693 MINT-7947479 STRING: ENSP00000261965
    TUBG1P232582, ENSP000002514134MINT-7945693 MINT-7947479 STRING: ENSP00000251413
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    TUBGCP2Q9BSJ22, ENSP000002529364MINT-7945693 MINT-7947479 STRING: ENSP00000252936
    HSPD1P108092, ENSP000003400194MINT-7945693 MINT-7947479 STRING: ENSP00000340019
    ACTBP607092, ENSP000003499604MINT-7945693 MINT-7947479 STRING: ENSP00000349960
    PFKPQ018132, ENSP000003705174MINT-7945693 MINT-7947479 STRING: ENSP00000370517
    PPP1CAP621362, ENSP000003260314MINT-7945693 MINT-7947479 STRING: ENSP00000326031
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    FHL2Q141923, ENSP000003229094I2D: score=3 STRING: ENSP00000322909
    CAV3P565393, ENSP000003419404I2D: score=2 STRING: ENSP00000341940
    MAPK3P273613, ENSP000002630254I2D: score=2 STRING: ENSP00000263025
    NOS1P294753, ENSP000003207584I2D: score=2 STRING: ENSP00000320758
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    ATP6V0A4Q9HBG43, ENSP000002538564I2D: score=2 STRING: ENSP00000253856
    SUMO2P619563, ENSP000004059654I2D: score=1 STRING: ENSP00000405965
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    ABCF3Q9NUQ82MINT-7945693 MINT-7947479
    ACTL6AO960192MINT-7945693 MINT-7947479
    ACTR1AP611632MINT-7945693 MINT-7947479
    ACTR2P611602MINT-7945693 MINT-7947479
    ADNPQ9H2P02MINT-7945693 MINT-7947479
    AHNAKQ096662MINT-7945693 MINT-7947479
    ANAPC1Q9H1A42MINT-7945693 MINT-7947479
    ANLNQ9NQW62MINT-7945693 MINT-7947479
    AP1B1Q105672MINT-7945693 MINT-7947479
    ARCN1P484442MINT-7945693 MINT-7947479
    ARHGEF1Q928882MINT-7945693 MINT-7947479
    ARHGEF2Q929742MINT-7945693 MINT-7947479
    ARID1AO144972MINT-7945693 MINT-7947479
    AURKBQ96GD42MINT-7945693 MINT-7947479
    BAZ1AQ9NRL22MINT-7945693 MINT-7947479
    BCAS2O759342MINT-7945693 MINT-7947479
    BCLAF1Q9NYF82MINT-7945693 MINT-7947479
    BRD8Q9H0E92MINT-7945693 MINT-7947479
    BTAF1O149812MINT-7945693 MINT-7947479
    BUB1O436832MINT-7945693 MINT-7947479
    BUB1BO605662MINT-7945693 MINT-7947479
    BUB3O436842MINT-7945693 MINT-7947479
    BZW1Q7L1Q62MINT-7945693 MINT-7947479
    CAPGP401212MINT-7945693 MINT-7947479
    CAPZA1P529072MINT-7945693 MINT-7947479
    CCNB1P146352MINT-7945693 MINT-7947479
    CCT2P783712MINT-7945693 MINT-7947479
    CCT3P493682MINT-7945693 MINT-7947479
    CCT4P509912MINT-7945693 MINT-7947479
    CCT5P486432MINT-7945693 MINT-7947479
    CCT6AP402272MINT-7945693 MINT-7947479
    CCT7Q998322MINT-7945693 MINT-7947479
    CCT8P509902MINT-7945693 MINT-7947479
    CDC16Q130422MINT-7945693 MINT-7947479
    CDC23Q9UJX22MINT-7945693 MINT-7947479
    CDC27P302602MINT-7945693 MINT-7947479
    CDC73Q6P1J92MINT-7945693 MINT-7947479
    CDK9P507502MINT-7945693 MINT-7947479
    CDKN2AIPQ9NXV62MINT-7945693 MINT-7947479
    CHD1LQ86WJ12MINT-7945693 MINT-7947479
    CHD8Q9HCK82MINT-7945693 MINT-7947479
    CHEK1O147572MINT-7945693 MINT-7947479
    CKAP5Q140082MINT-7945693 MINT-7947479
    COPAP536212MINT-7945693 MINT-7947479
    COPB1P536182MINT-7945693 MINT-7947479
    COPB2P356062MINT-7945693 MINT-7947479
    COPG1Q9Y6782MINT-7945693 MINT-7947479
    COPG2Q9UBF22MINT-7945693 MINT-7947479
    COPS5Q929052MINT-7945693 MINT-7947479
    CPSF1Q105702, ENSP000003393534MINT-7945693 STRING: ENSP00000339353
    CPSF2Q9P2I02MINT-7945693 MINT-7947479
    CPSF3Q9UKF62MINT-7945693 MINT-7947479
    CPSF7Q8N6842MINT-7945693 MINT-7947479
    CSE1LP550602MINT-7945693 MINT-7947479
    CSTF3Q129962MINT-7945693 MINT-7947479
    CUL1Q136162MINT-7945693 MINT-7947479
    DCTN2Q135612MINT-7945693 MINT-7947479
    DDX17Q928412MINT-7945693 MINT-7947479
    DDX19AQ9NUU72MINT-7945693 MINT-7947479
    DDX19BQ9UMR22MINT-7945693 MINT-7947479
    DDX39AO001482MINT-7945693 MINT-7947479
    DDX39BQ138382MINT-7945693 MINT-7947479
    DDX3XO005712MINT-7945693 MINT-7947479
    DDX41Q9UJV92MINT-7945693 MINT-7947479
    DDX42Q86XP32MINT-7945693 MINT-7947479
    DDX5P178442MINT-7945693 MINT-7947479
    DEPDC7Q96QD52MINT-7945693 MINT-7947479
    DFNA5O604432MINT-7945693 MINT-7947479
    DIAPH1O606102MINT-7945693 MINT-7947479
    DIDO1Q9BTC02MINT-7945693 MINT-7947479
    DMAP1Q9NPF52MINT-7945693 MINT-7947479
    DNAJA1P316892MINT-7945693 MINT-7947479
    DNM1LO004292MINT-7945693 MINT-7947479
    DNM2P505702MINT-7945693 MINT-7947479
    DRG1Q9Y2952MINT-7945693 MINT-7947479
    DSPP159242MINT-7945693 MINT-7947479
    DYNC1H1Q142042MINT-7945693 MINT-7947479
    DYNC1LI2O432372MINT-7945693 MINT-7947479
    EEF1A1P681042MINT-7945693 MINT-7947479
    EFTUD2Q150292MINT-7945693 MINT-7947479
    EHD1Q9H4M92MINT-7945693 MINT-7947479
    EHD4Q9H2232MINT-7945693 MINT-7947479
    EIF2S3P410912MINT-7945693 MINT-7947479
    EIF3GO758212MINT-7945693 MINT-7947479
    EIF3IQ133472MINT-7945693 MINT-7947479
    EIF4A1P608422MINT-7945693 MINT-7947479
    EIF4A3P389192MINT-7945693 MINT-7947479
    EIF4G2P783442MINT-7945693 MINT-7947479
    EIF5BO608412MINT-7945693 MINT-7947479
    ELAVL1Q157172MINT-7945693 MINT-7947479
    ENAHQ8N8S72MINT-7945693 MINT-7947479
    ENSG00000183311P074372MINT-7945693 MINT-7947479
    ENSG00000206490Q8NE712MINT-7945693 MINT-7947479
    ENSG00000215425Q138382MINT-7945693 MINT-7947479
    ENSG00000224156P074372MINT-7945693 MINT-7947479
    ENSG00000225073Q138382MINT-7945693 MINT-7947479
    ENSG00000225859Q138382MINT-7945693 MINT-7947479
    ENSG00000225989Q8NE712MINT-7945693 MINT-7947479
    ENSG00000227739P074372MINT-7945693 MINT-7947479
    ENSG00000229496Q138382MINT-7945693 MINT-7947479
    ENSG00000229684P074372MINT-7945693 MINT-7947479
    ENSG00000230624Q138382MINT-7945693 MINT-7947479
    ENSG00000231129Q8NE712MINT-7945693 MINT-7947479
    ENSG00000232169Q8NE712MINT-7945693 MINT-7947479
    ENSG00000232421P074372MINT-7945693 MINT-7947479
    ENSG00000232575P074372MINT-7945693 MINT-7947479
    ENSG00000235067P074372MINT-7945693 MINT-7947479
    ENSG00000235439Q138382MINT-7945693 MINT-7947479
    ENSG00000236149Q8NE712MINT-7945693 MINT-7947479
    ENSG00000236342Q8NE712MINT-7945693 MINT-7947479
    EPPK1P581072MINT-7945693 MINT-7947479
    EPS8L2Q9H6S32MINT-7945693 MINT-7947479
    ETF1P624952MINT-7945693 MINT-7947479
    ETV6P412122MINT-7945693 MINT-7947479
    EXOC2Q96KP12MINT-7945693 MINT-7947479
    EXOC4Q96A652MINT-7945693 MINT-7947479
    EXOC5O004712MINT-7945693 MINT-7947479
    EXOC7Q9UPT52MINT-7945693 MINT-7947479
    EXOSC10Q017802MINT-7945693 MINT-7947479
    FAM129BQ96TA12MINT-7945693 MINT-7947479
    FANCIQ9NVI12MINT-7945693 MINT-7947479
    FASNP493272MINT-7945693 MINT-7947479
    FEN1P397482MINT-7945693 MINT-7947479
    FERMT1Q9BQL62MINT-7945693 MINT-7947479
    FHOD1Q9Y6132MINT-7945693 MINT-7947479
    FUSP356372MINT-7945693 MINT-7947479
    GATAD2AQ86YP42MINT-7945693 MINT-7947479
    GCN1L1Q926162MINT-7945693 MINT-7947479
    GEMIN4P576782MINT-7945693 MINT-7947479
    GTF2IP783472MINT-7945693 MINT-7947479
    GTF3C2Q8WUA42MINT-7945693 MINT-7947479
    GULP1Q9UBP92MINT-7945693 MINT-7947479
    HBS1LQ9Y4502MINT-7945693 MINT-7947479
    HDAC1Q135472MINT-7945693 MINT-7947479
    HDAC2Q927692MINT-7945693 MINT-7947479
    HDLBPQ003412MINT-7945693 MINT-7947479
    HELLSQ9NRZ92MINT-7945693 MINT-7947479
    HIP1RO751462MINT-7945693 MINT-7947479
    HIRAP541982MINT-7945693 MINT-7947479
    HLTFQ145272MINT-7945693 MINT-7947479
    HNRNPA2B1P226262MINT-7945693 MINT-7947479
    HNRNPCP079102MINT-7945693 MINT-7947479
    HNRNPFP525972MINT-7945693 MINT-7947479
    HNRNPH1P319432MINT-7945693 MINT-7947479
    HNRNPKP619782MINT-7945693 MINT-7947479
    HNRNPMP522722MINT-7945693 MINT-7947479
    HNRNPUQ008392MINT-7945693 MINT-7947479
    HSP90AA1P079002MINT-7945693 MINT-7947479
    HSP90AB1P082382MINT-7945693 MINT-7947479
    HSP90B1P146252MINT-7945693 MINT-7947479
    HSPA12AO433012MINT-7945693 MINT-7947479
    HSPA5P110212MINT-7945693 MINT-7947479
    HSPA8P111422MINT-7945693 MINT-7947479
    HSPB1P047922MINT-7945693 MINT-7947479
    ILF2Q129052MINT-7945693 MINT-7947479
    INTS1Q8N2012MINT-7945693 MINT-7947479
    INTS3Q68E012MINT-7945693 MINT-7947479
    IPO5O004102MINT-7945693 MINT-7947479
    IPO9Q96P702MINT-7945693 MINT-7947479
    IQGAP1P469402MINT-7945693 MINT-7947479
    KDM1AO603412MINT-7945693 MINT-7947479
    KHDRBS1Q076662MINT-7945693 MINT-7947479
    KIF11P527322MINT-7945693 MINT-7947479
    KIF21AQ7Z4S62MINT-7945693 MINT-7947479
    KIF2CQ996612MINT-7945693 MINT-7947479
    KIF4AO952392MINT-7945693 MINT-7947479
    KPNA2P522922MINT-7945693 MINT-7947479
    KPNB1Q149742MINT-7945693 MINT-7947479
    LIMS1P480592MINT-7945693 MINT-7947479
    LMNAP025452MINT-7945693 MINT-7947479
    LRRC40Q9H9A62MINT-7945693 MINT-7947479
    LRWD1Q9UFC02MINT-7945693 MINT-7947479
    MAD1L1Q9Y6D92MINT-7945693 MINT-7947479
    MAP2K7O147332MINT-7945693 MINT-7947479
    MATR3P432432MINT-7945693 MINT-7947479
    MDN1Q9NU222MINT-7945693 MINT-7947479
    MED4Q9NPJ62MINT-7945693 MINT-7947479
    MRE11AP499592MINT-7945693 MINT-7947479
    MSH2P432462MINT-7945693 MINT-7947479
    MSH6P527012MINT-7945693 MINT-7947479
    MTA2O947762MINT-7945693 MINT-7947479
    MVPQ147642MINT-7945693 MINT-7947479
    MYH9P355792MINT-7945693 MINT-7947479
    MYO15BQ96JP22MINT-7945693 MINT-7947479
    NACC1Q96RE72MINT-7945693 MINT-7947479
    NBNO609342MINT-7945693 MINT-7947479
    NCAPD2Q150212MINT-7945693 MINT-7947479
    NCAPHQ150032MINT-7945693 MINT-7947479
    NCOR1O753762MINT-7945693 MINT-7947479
    NDC80O147772MINT-7945693 MINT-7947479
    NELFBQ8WX922MINT-7945693 MINT-7947479
    NIPBLQ6KC792MINT-7945693 MINT-7947479
    NONOQ152332MINT-7945693 MINT-7947479
    NSFP464592MINT-7945693 MINT-7947479
    NSUN5Q96P112MINT-7945693 MINT-7947479
    NUDCQ9Y2662MINT-7945693 MINT-7947479
    NUF2Q9BZD42MINT-7945693 MINT-7947479
    NUP155O756942MINT-7945693 MINT-7947479
    ORC2Q134162MINT-7945693 MINT-7947479
    ORC3Q9UBD52MINT-7945693 MINT-7947479
    OXSR1O957472MINT-7945693 MINT-7947479
    PAK4O960132MINT-7945693 MINT-7947479
    PARVAQ9NVD72MINT-7945693 MINT-7947479
    PARVBQ9HBI12MINT-7945693 MINT-7947479
    PCBP2Q153662MINT-7945693 MINT-7947479
    PDLIM7Q9NR122MINT-7945693 MINT-7947479
    PHGDHO431752MINT-7945693 MINT-7947479
    PICALMQ134922MINT-7945693 MINT-7947479
    PKN2Q165132MINT-7945693 MINT-7947479
    PLECQ151492MINT-7945693 MINT-7947479
    PLK1P533502MINT-7945693 MINT-7947479
    PLRG1O436602MINT-7945693 MINT-7947479
    PNNQ9H3072MINT-7945693 MINT-7947479
    POLD1P283402MINT-7945693 MINT-7947479
    POLR1CO151602MINT-7945693 MINT-7947479
    PPP2R1AP301532MINT-7945693 MINT-7947479
    PRKDCP785272MINT-7945693 MINT-7947479
    PRPF19Q9UMS42MINT-7945693 MINT-7947479
    PRPF6O949062MINT-7945693 MINT-7947479
    PRPF8Q6P2Q92MINT-7945693 MINT-7947479
    PSMC1P621912MINT-7945693 MINT-7947479
    PSMC2P359982MINT-7945693 MINT-7947479
    PSMC3P179802MINT-7945693 MINT-7947479
    PSMC4P436862MINT-7945693 MINT-7947479
    PSMC5P621952MINT-7945693 MINT-7947479
    PSMC6P623332MINT-7945693 MINT-7947479
    PSMD1Q994602MINT-7945693 MINT-7947479
    PSMD11O002312MINT-7945693 MINT-7947479
    PSMD12O002322MINT-7945693 MINT-7947479
    PSMD13Q9UNM62MINT-7945693 MINT-7947479
    PSMD2Q132002MINT-7945693 MINT-7947479
    PSMD3O432422MINT-7945693 MINT-7947479
    PTBP1P265992MINT-7945693 MINT-7947479
    RACGAP1Q9H0H52MINT-7945693 MINT-7947479
    RAD18Q9NS912MINT-7945693 MINT-7947479
    RAD50Q928782MINT-7945693 MINT-7947479
    RALYQ9UKM92MINT-7945693 MINT-7947479
    RANBP2P497922MINT-7945693 MINT-7947479
    RANGAP1P460602MINT-7945693 MINT-7947479
    RBBP5Q152912MINT-7945693 MINT-7947479
    RBBP7Q165762MINT-7945693 MINT-7947479
    RBM17Q96I252MINT-7945693 MINT-7947479
    RBM39Q144982MINT-7945693 MINT-7947479
    RBM4Q9BWF32MINT-7945693 MINT-7947479
    RBM45Q8IUH32MINT-7945693 MINT-7947479
    RBMXP381592MINT-7945693 MINT-7947479
    RCOR1Q9UKL02MINT-7945693 MINT-7947479
    RFC2P352502MINT-7945693 MINT-7947479
    RFC3P409382MINT-7945693 MINT-7947479
    RFC4P352492MINT-7945693 MINT-7947479
    RFC5P409372MINT-7945693 MINT-7947479
    RIF1Q5UIP02MINT-7945693 MINT-7947479
    ROCK2O751162MINT-7945693 MINT-7947479
    RPL13P263732MINT-7945693 MINT-7947479
    RPL22P352682MINT-7945693 MINT-7947479
    RPL31P628992MINT-7945693 MINT-7947479
    RPLP0P053882MINT-7945693 MINT-7947479
    RPS6KA4O756762MINT-7945693 MINT-7947479
    RPS6KB2Q9UBS02MINT-7945693 MINT-7947479
    RTCBQ9Y3I02MINT-7945693 MINT-7947479
    RUVBL1Q9Y2652MINT-7945693 MINT-7947479
    RUVBL2Q9Y2302MINT-7945693 MINT-7947479
    SART1O432902MINT-7945693 MINT-7947479
    SCYL2Q6P3W72MINT-7945693 MINT-7947479
    SEH1LQ96EE32MINT-7945693 MINT-7947479
    SEPT9Q9UHD82MINT-7945693 MINT-7947479
    SETXQ7Z3332MINT-7945693 MINT-7947479
    SF3A1Q154592MINT-7945693 MINT-7947479
    SF3A3Q128742MINT-7945693 MINT-7947479
    SF3B1O755332MINT-7945693 MINT-7947479
    SF3B2Q134352MINT-7945693 MINT-7947479
    SF3B3Q153932MINT-7945693 MINT-7947479
    SF3B6Q9Y3B42MINT-7945693 MINT-7947479
    SFPQP232462MINT-7945693 MINT-7947479
    SHROOM3Q8TF722MINT-7945693 MINT-7947479
    SMARCA5O602642MINT-7945693 MINT-7947479
    SMARCAD1Q9H4L72MINT-7945693 MINT-7947479
    SMARCB1Q128242MINT-7945693 MINT-7947479
    SMARCC1Q929222MINT-7945693 MINT-7947479
    SMARCC2Q8TAQ22MINT-7945693 MINT-7947479
    SMARCD1Q96GM52MINT-7945693 MINT-7947479
    SMARCE1Q969G32MINT-7945693 MINT-7947479
    SMC1AQ146832MINT-7945693 MINT-7947479
    SMC2O953472MINT-7945693 MINT-7947479
    SMC3Q9UQE72MINT-7945693 MINT-7947479
    SMC4Q9NTJ32MINT-7945693 MINT-7947479
    SMCHD1A6NHR92MINT-7945693 MINT-7947479
    SMN1Q166372MINT-7945693 MINT-7947479
    SMN2Q166372MINT-7945693 MINT-7947479
    SNRNP200O756432MINT-7945693 MINT-7947479
    SNRNP40Q96DI72MINT-7945693 MINT-7947479
    SNRNP70P086212MINT-7945693 MINT-7947479
    SNRPD3P623182MINT-7945693 MINT-7947479
    SPATA5Q8NB902MINT-7945693 MINT-7947479
    SPTAN1Q138132MINT-7945693 MINT-7947479
    SPTBN1Q010822MINT-7945693 MINT-7947479
    SRP54P610112MINT-7945693 MINT-7947479
    SRP68Q9UHB92MINT-7945693 MINT-7947479
    SRP72O760942MINT-7945693 MINT-7947479
    SRRM1Q8IYB32MINT-7945693 MINT-7947479
    SRSF1Q079552MINT-7945693 MINT-7947479
    SRSF7Q166292MINT-7945693 MINT-7947479
    SUGT1Q9Y2Z02MINT-7945693 MINT-7947479
    SYMPKQ927972MINT-7945693 MINT-7947479
    TARDBPQ131482MINT-7945693 MINT-7947479
    TBL1XR1Q9BZK72MINT-7945693 MINT-7947479
    TCP1P179872MINT-7945693 MINT-7947479
    THRAP3Q9Y2W12MINT-7945693 MINT-7947479
    TIAL1Q010852MINT-7945693 MINT-7947479
    TLN1Q9Y4902MINT-7945693 MINT-7947479
    TMPOP421662MINT-7945693 MINT-7947479
    TRAP1Q129312MINT-7945693 MINT-7947479
    TRIM28Q132632MINT-7945693 MINT-7947479
    TRIP13Q156452MINT-7945693 MINT-7947479
    TRUB1Q8WWH52MINT-7945693 MINT-7947479
    TSG101Q998162MINT-7945693 MINT-7947479
    TUBA4AP683662MINT-7945693 MINT-7947479
    TUBBP074372MINT-7945693 MINT-7947479
    TUBB4BP683712MINT-7945693 MINT-7947479
    TWF1Q127922MINT-7945693 MINT-7947479
    U2AF1Q010812MINT-7945693 MINT-7947479
    U2AF2P263682MINT-7945693 MINT-7947479
    U2SURPO150422MINT-7945693 MINT-7947479
    UBA5Q9GZZ92MINT-7945693 MINT-7947479
    UBE2MP610812MINT-7945693 MINT-7947479
    UBE2NP610882MINT-7945693 MINT-7947479
    UBL4AP114412MINT-7945693 MINT-7947479
    UCHL5Q9Y5K52MINT-7945693 MINT-7947479
    UNC45AQ9H3U12MINT-7945693 MINT-7947479
    UPF1Q929002MINT-7945693 MINT-7947479
    UPF2Q9HAU52MINT-7945693 MINT-7947479
    USP39Q53GS92MINT-7945693 MINT-7947479
    VIMP086702MINT-7945693 MINT-7947479
    VPS33BQ9H2672MINT-7945693 MINT-7947479
    WDR18Q9BV382MINT-7945693 MINT-7947479
    WDR33Q9C0J82MINT-7945693 MINT-7947479
    XRN2Q9H0D62MINT-7945693 MINT-7947479
    ZNF638Q149662MINT-7945693 MINT-7947479
    DYNLL1P631673I2D: score=3 
    ATG101Q9BSB43I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    DLG4P783523I2D: score=1 
    GBASO753233I2D: score=1 
    PCNAP120043I2D: score=1 
    PPP1CCP368733I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    YWHABP319463I2D: score=1 
    YWHAZP631043I2D: score=1 
    ACIN1Q9UKV32MINT-7945693
    AKAP8O438232MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANXA11P509952MINT-7947479
    AP3B1O002032MINT-7945693
    APBB1IPQ7Z5R62MINT-7945693
    API5Q9BZZ52MINT-7945693
    AQRO603062MINT-7945693
    ARAP1Q96P482MINT-7945693
    ARF4P180852MINT-7945693
    ARF5P840852MINT-7945693
    ARFGEF2Q9Y6D52MINT-7945693
    ARGLU1Q9NWB62MINT-7947479
    ASUNQ9NVM92MINT-7945693
    ATMQ133152MINT-7945693
    ATRQ135352MINT-7945693
    ATRXP461002MINT-7945693
    AURKAO149652MINT-7945693
    BABAM1Q9NWV82MINT-7945693
    BCL7CQ8WUZ02MINT-7945693
    BIDP559572MINT-7947479
    BLMP541322MINT-7945693
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRIX1Q8TDN62MINT-7945693
    BZW2Q9Y6E22MINT-7945693
    C7orf13Q8NI282MINT-7947479
    C7orf55-LUC7L2Q9Y3832MINT-7945693
    CAND1Q86VP62MINT-7945693
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCNT1O605632MINT-7945693
    CDC20Q128342MINT-7947479
    CDK1P064932MINT-7945693
    CDK12Q9NYV42MINT-7945693
    CDK3Q005262MINT-7945693
    CHD3Q128732MINT-7945693
    CHD4Q148392MINT-7945693
    CHD7Q9P2D12MINT-7945693
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CLP1Q929892MINT-7945693
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPS3Q9UNS22MINT-7945693
    COPS6Q7L5N12MINT-7945693
    CPNE3O751312MINT-7945693
    CPSF4O956392MINT-7945693
    CSKP412402MINT-7945693
    CTNND1O607162MINT-7947479
    CTTNQ142472MINT-7945693
    CWC15Q9P0132MINT-7947479
    DCTN1Q142032MINT-7945693
    DDB1Q165312MINT-7947479
    DDX1Q924992MINT-7945693
    DDX21Q9NR302MINT-7945693
    DDX23Q9BUQ82MINT-7945693
    DDX46Q7L0142MINT-7945693
    DDX47Q9H0S42MINT-7947479
    DDX6P261962MINT-7947479
    DHX8Q145622MINT-7945693
    DHX9Q082112MINT-7945693
    DIAPH3Q9NSV42MINT-7945693
    DNAJC13O751652MINT-7945693
    DOCK1Q141852MINT-7945693
    DOCK2Q926082MINT-7945693
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DPF2Q927852MINT-7945693
    DTYMKP239192MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    EBNA1BP2Q998482MINT-7945693
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEFSECP577722MINT-7945693
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S1P051982MINT-7945693
    EIF2S2P200422MINT-7945693
    EIF3BP558842MINT-7947479
    EIF3EP602282MINT-7945693
    EIF3HO153722MINT-7945693
    EIF3LQ9Y2622MINT-7945693
    EIF4A2Q142402MINT-7947479
    ELF2Q157232MINT-7947479
    ENSG00000096150P622692MINT-7945693
    ENSG00000206287Q065872MINT-7945693
    ENSG00000206289P287022MINT-7947479
    ENSG00000215077P254402MINT-7947479
    ENSG00000223367P622692MINT-7945693
    ENSG00000226225P622692MINT-7945693
    ENSG00000226788Q065872MINT-7945693
    ENSG00000227322P287022MINT-7947479
    ENSG00000228333P287022MINT-7947479
    ENSG00000228520Q065872MINT-7945693
    ENSG00000231115Q065872MINT-7945693
    ENSG00000231321P287022MINT-7947479
    ENSG00000234507P254402MINT-7947479
    ENSG00000234704P254402MINT-7947479
    ENSG00000235107Q065872MINT-7945693
    ENSG00000235307P254402MINT-7947479
    ENSG00000235650P622692MINT-7945693
    ENSG00000235712P287022MINT-7947479
    ENSG00000258947Q135092MINT-7945693
    EPB41L3Q9Y2J22MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC1Q9NV702MINT-7945693
    EXOC3O606452MINT-7945693
    EXOSC6Q5RKV62MINT-7945693
    FAF1Q9UNN52MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FIP1L1Q6UN152MINT-7945693
    FUBP1Q96AE42MINT-7945693
    FYTTD1Q96QD92MINT-7945693
    G3BP2Q9UN862MINT-7945693
    GAPDHP044062MINT-7947479
    GATAD2BQ8WXI92MINT-7945693
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GNA14O958372MINT-7945693
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GSPT1P151702MINT-7945693
    GTF3C1Q127892MINT-7945693
    GTF3C3Q9Y5Q92MINT-7945693
    GTF3C4Q9UKN82MINT-7945693
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GTPBP4Q9BZE42MINT-7945693
    HAUS7Q998712MINT-7947479
    HIC2Q96JB32MINT-7947479
    HNRNPA0Q131512MINT-7945693
    HNRNPA1P096512MINT-7945693
    HNRNPA3P519912MINT-7945693
    HNRNPABQ997292MINT-7945693
    HNRNPDQ141032MINT-7945693
    HNRNPRO433902MINT-7945693
    HSPA6P170662MINT-7947479
    HTATSF1O437192MINT-7945693
    HUWE1Q7Z6Z72MINT-7947479
    IKQ131232MINT-7945693
    IKBKAPO951632MINT-7947479
    ILF3Q129062MINT-7945693
    ILKQ134182MINT-7945693
    INTS12Q96CB82MINT-7945693
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO7O953732MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KIAA1279Q96EK52MINT-7945693
    KIF27Q86VH22MINT-7945693
    KMT2DO146862MINT-7945693
    KPNA1P522942MINT-7945693
    KTI12Q96EK92MINT-7945693
    LAS1LQ9Y4W22MINT-7947479
    LDLRAP1Q5SW962MINT-7945693
    LENG9Q96B702MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC47Q8N1G42MINT-7945693
    LUC7L2Q9Y3832MINT-7945693
    MAGED2Q9UNF12MINT-7945693
    MAGEE2Q8TD902MINT-7947479
    MAP2K2P365072MINT-7945693
    MAP2K3P467342MINT-7945693
    MAP2K4P459852MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MBD3O959832MINT-7945693
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MELKQ146802MINT-7947479
    METTL13Q8N6R02MINT-7945693
    MLH1P406922MINT-7945693
    MLKLQ8NB162MINT-7945693
    MORF4L1Q9UBU82MINT-7945693
    MORF4L2Q150142MINT-7945693
    MPP2Q141682MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MTCL1Q9Y4B52MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NCAPGQ9BPX32MINT-7945693
    NCLP193382MINT-7945693
    NCOR2Q9Y6182MINT-7945693
    NELFCDQ8IXH72MINT-7945693
    NF1P213592MINT-7947479
    NFICP086512MINT-7945693
    NOLC1Q149782MINT-7945693
    NPM1P067482MINT-7947479
    NR2C2P491162MINT-7945693
    NR2F2P244682MINT-7945693
    NR2F6P105882MINT-7945693
    NRG1Q022972MINT-7947479
    NUDT21O438092MINT-7947479
    NUP107P577402MINT-7947479
    NUP153P497902MINT-7945693
    NUP37Q8NFH42MINT-7945693
    NUP93Q8N1F72MINT-7947479
    OLA1Q9NTK52MINT-7945693
    OTULINQ96BN82MINT-7945693
    PABPC1P119402MINT-7945693
    PABPN1Q86U422MINT-7945693
    PAK1Q131532MINT-7945693
    PARP1P098742MINT-7947479
    PARP4Q9UKK32MINT-7945693
    PAXIP1Q6ZW492MINT-7945693
    PBRM1Q86U862MINT-7945693
    PCBP1Q153652MINT-7947479
    PCF11O949132MINT-7945693
    PCNTO956132MINT-7947479
    PDCD6IPQ8WUM42MINT-7945693
    PELOQ9BRX22MINT-7947479
    PELP1Q8IZL82MINT-7945693
    PFKMP082371EBI-514788,EBI-514788
    PIK3R4Q995702MINT-7945693
    PKP3Q9Y4462MINT-7945693
    POGZQ7Z3K32MINT-7945693
    POLEQ078642MINT-7945693
    POLR2AP249282MINT-7945693
    POLR2EP193882MINT-7945693
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP2R1BP301542MINT-7945693
    PRCCQ927332MINT-7947479
    PRKAG1P546192MINT-7945693
    PRPF3O433952MINT-7947479
    PRPF40AO754002MINT-7945693
    PRPF4BQ135232MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUF60Q9UHX12MINT-7945693
    PUM1Q146712MINT-7947479
    PUM2Q8TB722MINT-7945693
    PURAQ005772MINT-7945693
    PWP1Q136102MINT-7945693
    RAD21O602162MINT-7945693
    RAE1P784062MINT-7945693
    RAVER1Q8IY672MINT-7947479
    RBBP4Q090282MINT-7947479
    RBM10P981752MINT-7945693
    RBM14Q96PK62MINT-7945693
    RBM15Q96T372MINT-7945693
    RBM7Q9Y5802MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RING1Q065872MINT-7945693
    RIOK1Q9BRS22MINT-7945693
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    RNF2Q994962MINT-7945693
    RPL12P300502MINT-7945693
    RPL19P840982MINT-7945693
    RPL23AP627502MINT-7945693
    RPL24P837312MINT-7947479
    RPL3P390232MINT-7945693
    RPL36Q9Y3U82MINT-7945693
    RPL4P365782MINT-7945693
    RPL7AP624242MINT-7945693
    RPL8P629172MINT-7945693
    RPS13P622772MINT-7947479
    RPS14P622632MINT-7945693
    RPS18P622692MINT-7945693
    RPS19P390192MINT-7945693
    RPS25P628512MINT-7945693
    RPS3P233962MINT-7945693
    RXRBP287022MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC23BQ154372MINT-7945693
    SEC24CP539922MINT-7947479
    SEC31BQ9NQW12MINT-7945693
    SENP3Q9H4L42MINT-7947479
    SEPT7Q161812MINT-7945693
    SF3A2Q154282MINT-7947479
    SF3B4Q154272MINT-7945693
    SHC1P293532MINT-7947479
    SHOC2Q9UQ132MINT-7945693
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA2P515312MINT-7945693
    SNAPC4Q5SXM22MINT-7947479
    SND1Q7KZF42MINT-7945693
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPB2P085792MINT-7945693
    SNRPD1P623142MINT-7947479
    SNRPEP623042MINT-7947479
    SNUPNO951492MINT-7945693
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SPATA5L1Q9BVQ72MINT-7945693
    SPENQ96T582MINT-7947479
    SQSTM1Q135012MINT-7945693
    SREK1Q8WXA92MINT-7947479
    SRP19P091322MINT-7945693
    SRRM2Q9UQ352MINT-7945693
    SRSF11Q055192MINT-7945693
    SRSF2Q011302MINT-7945693
    SRSF3P841032MINT-7945693
    SRSF4Q081702MINT-7947479
    SRSF5Q132432MINT-7945693
    SRSF6Q132472MINT-7945693
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG1Q8WVM72MINT-7945693
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SUPV3L1Q8IYB82MINT-7945693
    SYNCRIPO605062MINT-7945693
    TAF12Q165142MINT-7945693
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TAF9Q165942MINT-7945693
    TANC2Q9HCD62MINT-7947479
    TAOK1Q7L7X32MINT-7945693
    THAP1Q9NVV92MINT-7947479
    THOC1Q96FV92MINT-7945693
    THOC2Q8NI272MINT-7945693
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TNPO1Q929732MINT-7947479
    TOX4O948422MINT-7945693
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRIM21P194742MINT-7947479
    TRIP12Q146692MINT-7945693
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TTKP339812MINT-7945693
    TUBA1CQ9BQE32MINT-7947479
    TUBA3EQ6PEY22MINT-7945693
    TUBB1Q9H4B72MINT-7945693
    TUBB3Q135092MINT-7945693
    TUBGCP4Q9UGJ12MINT-7947479
    TUFMP494112MINT-7945693
    UBE2Q1Q7Z7E82MINT-7945693
    UBE2SQ167632MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UMPSP111722MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP48Q86UV52MINT-7945693
    VASPP505522MINT-7945693
    VPS33AQ96AX12MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    VRK1Q999862MINT-7945693
    WAPALQ7Z5K22MINT-7945693
    WDR5P619642MINT-7945693
    WIZO957852MINT-7945693
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    XPO6Q96QU82MINT-7945693
    XRCC6P129562MINT-7945693
    YBX3P169892MINT-7945693
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    YTHDC2Q9H6S02MINT-7945693
    YWHAEP622582MINT-7947479
    YY1P254902MINT-7945693
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF326Q5BKZ12MINT-7945693
    ALDOAENSP000003369274STRING: ENSP00000336927
    ALDOBENSP000003639884STRING: ENSP00000363988
    ALDOCENSP000002262534STRING: ENSP00000226253
    C12orf5ENSP000001792594STRING: ENSP00000179259
    FBP1ENSP000003644754STRING: ENSP00000364475
    FBP2ENSP000003644864STRING: ENSP00000364486
    HK2ENSP000002905734STRING: ENSP00000290573
    HK3ENSP000002924324STRING: ENSP00000292432
    HKDC1ENSP000003466434STRING: ENSP00000346643
    MAXENSP000003514904STRING: ENSP00000351490
    MPIENSP000003183184STRING: ENSP00000318318
    MYCENSP000003672074STRING: ENSP00000367207
    PFKFB1ENSP000003641454STRING: ENSP00000364145
    PFKFB2ENSP000003560474STRING: ENSP00000356047
    PFKFB3ENSP000003691004STRING: ENSP00000369100
    PFKFB4ENSP000002323754STRING: ENSP00000232375
    TKTENSP000004054554STRING: ENSP00000405455
    TKTL1ENSP000003589314STRING: ENSP00000358931
    TKTL2ENSP000002806054STRING: ENSP00000280605
    UBCENSP000003448184STRING: ENSP00000344818
    LTA4HENSP000002287404STRING: ENSP00000228740
    THNSL1ENSP000003655344STRING: ENSP00000365534
    ARPC3ENSP000002288254STRING: ENSP00000228825
    MAT1AENSP000003612874STRING: ENSP00000361287
    MAT2AENSP000003031474STRING: ENSP00000303147
    TUBG2ENSP000002514124STRING: ENSP00000251412
    TUBD1ENSP000003207974STRING: ENSP00000320797
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006002fructose 6-phosphate metabolic process IMP6444532
    GO:0006006glucose metabolic process TAS--
    GO:0006096glycolytic process TAS--
    GO:0032024positive regulation of insulin secretion IEA--

    PFKM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PFKM (K6PF)

    Selected HMDB Compounds for PFKM (see all 16)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    CDPCDP (see all 3)63-38-7--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    D-Tagatose 1,6-bisphosphate1,6-di-O-phosphono-D-tagatofuranose ----
    D-Tagatose 6-phosphate6-O-phosphono-D-tagatofuranose (see all 2)----
    Fructose 1,6-bisphosphateD-Fructose 1,6-biphosphate (see all 16)488-69-7--
    Fructose 6-phosphateD-Fructose 6-phosphate (see all 13)643-13-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    Selected Novoseek inferred chemical compound relationships for PFKM gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 59.1 6 14718702 (1), 10438462 (1), 7603532 (1), 1826293 (1) (see all 6)
    phosphocreatine 36.4 1 9829278 (1)
    carnitine 22.6 2 1826293 (1), 12149506 (1)
    atp 20.9 1 10438462 (1)
    lactate 20.2 3 8482676 (1), 12149506 (1)
    pyruvate 19.7 1 10438462 (1)
    glucose 19.4 10 14718702 (1), 7603532 (1), 12217956 (1), 8764833 (1) (see all 9)
    creatinine 10.2 1 10438462 (1)
    alanine 4.69 1 19218242 (1)
    lipid 0 1 7603532 (1)



    PFKM for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PFKM gene (4 alternative transcripts): 
    NM_000289.5  NM_001166686.1  NM_001166687.1  NM_001166688.1  

    Unigene Cluster for PFKM:

    Phosphofructokinase, muscle
    Hs.75160  [show with all ESTs]
    Unigene Representative Sequence: AK126020
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000550345 ENST00000549003 ENST00000550924 ENST00000549941 ENST00000550257
    ENST00000340802(uc001rrb.2) ENST00000547581(uc001rra.2) ENST00000546755
    ENST00000549366 ENST00000552792 ENST00000548288 ENST00000359794 ENST00000547066
    ENST00000546964(uc001rrd.3) ENST00000548720 ENST00000552989 ENST00000551548
    ENST00000551485
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PFKM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PFKM (see all 24):
    hsa-miR-320a hsa-miR-128 hsa-miR-3133 hsa-miR-3916 hsa-miR-3125 hsa-miR-320e hsa-miR-591 hsa-miR-542-3p
    SwitchGear 3'UTR luciferase reporter plasmidPFKM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PFKM
    Predesigned siRNA for gene silencing in human, mouse, rat PFKM
    Clone
    Products:
         
    OriGene clones in human, mouse for PFKM (see all 22)
    OriGene ORF clones in mouse, rat for PFKM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PFKM (NM_001166686)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PFKM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKM
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PFKM
    OriGene qSTAR qPCR primer pairs in human, mouse for PFKM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PFKM
      QuantiTect SYBR Green Assays in human, mouse, rat PFKM
      QuantiFast Probe-based Assays in human, mouse, rat PFKM

    Additional mRNA sequence: 

    AK126020.1 AK126229.1 AK303681.1 AK308185.1 AK312284.1 BC000534.2 BC007798.2 BC012799.2 
    BC013298.2 BC021203.2 CR541698.1 D21861.1 J05533.1 M26066.1 U24183.1 Y00698.1 

    Selected DOTS entries (see all 35):

    DT.95200400  DT.100821887  DT.453195  DT.95227048  DT.100821891  DT.95227047  DT.100821889  DT.451936 
    DT.102830750  DT.101968062  DT.100821888  DT.121130909  DT.95239472  DT.100821896  DT.101968583  DT.121130726 
    DT.121130748  DT.91766939  DT.91766943  DT.95227041  DT.95227049  DT.100774897  DT.100821892  DT.102830751 

    Selected AceView cDNA sequences (see all 459):

    BM707870 BQ073492 BQ214726 AI370819 AI193636 BE887098 BE794437 BQ073813 
    BM710783 AV707835 BU732958 BQ425020 Y00698 BM771640 AA152157 AW411025 
    BC021203 AL534236 BQ640633 AU123936 AK126020 AL045056 BQ639191 BU178090 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PFKM (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
    SP1:                                                              -     -     -     -     -     -                                               -     -         
    SP2:                                                              -     -     -     -     -     -                                               -     -         
    SP3:                                                                                                                                            -     -         
    SP4:        -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                               -     -         
    SP5:                                                              -     -     -     -     -     -                                         -     -     -     -   

    ExUns: 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^
    SP1:                                                                          -                       -                                                         
    SP2:                                                                          -                       -                                                         
    SP3:                                                                    -     -                       -                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 31 ^ 32
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for PFKM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PFKM expression in normal human tissues (normalized intensities)      PFKM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTCTGCCC
    PFKM Expression
    About this image


    PFKM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
     
     Testis (Reproductive System)
     
     Adrenal Gland (Endocrine System)
     
     Skeletal Muscle (Muscoskeletal System)
    PFKM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PFKM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75160
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PFKM gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pfkm1 , 5 phosphofructokinase, muscle1, 5 90.17(n)1
    97.82(a)1
      15 (54.09 cM)5
    186421  NM_021514.41  NP_067489.31 
     980925895 
    chicken
    (Gallus gallus)
    Aves PFKM1 phosphofructokinase, muscle 75.89(n)
    83.97(a)
      374064  NM_204223.1  NP_989554.2 
    lizard
    (Anolis carolinensis)
    Reptilia PFKM6
    phosphofructokinase, muscle
    85(a)
    1 ↔ 1
    GL343536.1(124076-178939)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045100.12   -- 75.32(n)    BC045100.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pfkma1 phosphofructokinase, muscle a 71.74(n)
    79.79(a)
      447836  NM_001004575.1  NP_001004575.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pfk1 , 3 glycolysis 6-phosphofructokinase3
    Phosphofructokinase1
    54(a)3
    60.91(n)1
    60.86(a)1
      360601  NM_165747.41  NP_724891.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H10A.1a3
    Y71H10A.11
    phosphofructokinase3
    Y71H10A.11
    56(a)
    (best of 3)3
    57.07(n)1
    56.76(a)1
      X(2976190-2980515)3
    1805831  NM_171643.31  NP_741738.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PFK26
    PFK16
    Beta subunit of heterooctameric phosphofructokinas...
    Alpha subunit of heterooctameric phosphofructokina...
    34(a)
    34(a)
    many ↔ many
    many ↔ many
    XIII(671887-674766) YMR205C
    VII(970771-973734) YGR240C


    ENSEMBL Gene Tree for PFKM (if available)
    TreeFam Gene Tree for PFKM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PFKM gene
    PFKP2  PFKL2  
    13 SIMAP similar genes for PFKM using alignment to 23 protein entries:     K6PF_HUMAN (see all proteins):
    DKFZp779O048    PKP2    PFKP    FLT3LG    PFK-P    DKFZp686L2097
    GART    DKFZp686G1648    PS1TP6    PFKL    DKFZp666K083    PHACTR1
    PPARD

    PFKM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PFKM (see all 932)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22285001,2,,4
    C,F,O,HGlycogen storage disease 7 (GSD7)4 --48359745(+) ACTCCG/AAGCTG 8 /Q /R mis1 ese338Minor allele frequency- A:0.18MN EA NA NS CSA WA EU 11438
    rs412919711,2,,4
    C,FGlycogen storage disease 7 (GSD7)4 --48371939(+) TTACCG/ATAATG 8 /H /R mis15Minor allele frequency- A:0.01NA EU 5997
    VAR_0060674
    Glycogen storage disease 7 (GSD7)4--see VAR_0060672 D A mis40--------
    VAR_0060634
    Glycogen storage disease 7 (GSD7)4--see VAR_0060632 R L mis40--------
    VAR_0060664
    Glycogen storage disease 7 (GSD7)4--see VAR_0060662 G D mis40--------
    VAR_0060684
    Glycogen storage disease 7 (GSD7)4--see VAR_0060682 W C mis40--------
    VAR_0060644
    Glycogen storage disease 7 (GSD7)4--see VAR_0060642 R P mis40--------
    rs1219181931,2
    Cpathogenic148357209(+) GGTTCA/C/G/
            
    AGTTG
    12 P R L mis10--------
    rs1808924061,2
    --45529160(+) ACCCCA/GCATTT 1 -- us2k10--------
    rs1455948571,2
    --48330661(+) TGTCTA/GGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PFKM (48498922 - 48540187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PFKM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508673CNV Loss20534489
    nsv8971CNV Gain+Loss18304495
    dgv509e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): PFKM
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610681   
    OMIM disorders: 232800  
    UniProtKB/Swiss-Prot: K6PF_HUMAN, P08237
  • Glycogen storage disease 7 (GSD7) [MIM:232800]: A metabolic disorder characterized by exercise
    intolerance with associated nausea and vomiting, muscle cramping, exertional myopathy and compensated hemolysis.
    Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after
    vigorous exercise. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for PFKM (see all 24):    About MalaCards
    glycogen storage disease vii    phosphoglycerate kinase deficiency    hyperuricemia    glycogen storage disease
    gastric ulcer    lactic acidosis    hemolytic anemia    down syndrome
    myopathy    insulin resistance    mental retardation    pneumonia
    diabetes mellitus    hypoxia    schizophrenia    tuberculosis
    arthritis    melanoma    pancreatitis    myeloma

    3 diseases from the University of Copenhagen DISEASES database for PFKM:
    Glycogen storage disease     Myopathy     Diabetes mellitus

    PFKM for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for PFKM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphofructokinase deficiency 98.8 60 1824792 (4), 14718702 (3), 17608317 (3), 8659544 (2) (see all 29)
    mcardles disease 84.9 8 14718702 (1), 10809925 (1), 9541495 (1), 2018547 (1) (see all 5)
    myopathy 67.5 5 8659544 (1), 7479776 (1), 7825568 (1), 1394261 (1) (see all 5)
    hemolysis 54.9 4 8785459 (2), 7603526 (1), 7550225 (1)
    hyperuricemia 53 1 1838230 (1)
    mitochondrial diseases 34.9 1 7603532 (1)
    down syndrome 21.4 2 15793789 (1)
    acidosis 17.2 1 9541495 (1)
    niddm 0 4 8661033 (1)

    Genetic Association Database (GAD): PFKM
    Human Genome Epidemiology (HuGE) Navigator: PFKM (4 documents)

    Export disorders for PFKM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PFKM gene, integrated from 10 sources (see all 128):
    (articles sorted by number of sources associating them with PFKM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel mutations in non-Ashkenazi Italian patients with muscle phosphofructokinase deficiency. (PubMed id 7513946)1, 2, 9 Tsujino S.... DiMauro S. (Am. J. Hum. Genet. 1994)
    2. Nonsense mutation in the phosphofructokinase muscle subunit gene associated with retention of intron 10 in one of the isolated transcripts in Ashkenazi Jewish patients with Tarui disease. (PubMed id 7479776)1, 4, 9 Vasconcelos O.... Goldfarb L.G. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    3. Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency. (PubMed id 7825568)1, 2, 9 Raben N....Heinisch J.J. (Am. J. Hum. Genet. 1995)
    4. Mutations in muscle phosphofructokinase gene. (PubMed id 7550225)1, 2, 9 Raben N. and Sherman J.B. (Hum. Mutat. 1995)
    5. Structure of the entire human muscle phosphofructokinase-encoding gene: a two-promoter system. (PubMed id 1833270)1, 2, 9 Yamasaki T.... Tarui S. (Gene 1991)
    6. Alternative splicing of the transcript encoding the human muscle isoenzyme of phosphofructokinase. (PubMed id 2140567)1, 2, 9 Sharma P.M.... McLachlan A. (J. Biol. Chem. 1990)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    10. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5213 HGNC: 8877 AceView: PFKM Ensembl:ENSG00000152556 euGenes: HUgn5213
    ECgene: PFKM Kegg: 5213 H-InvDB: PFKM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PFKM Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PFKM[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PFKM gene:
    Search GeneIP for patents involving PFKM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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