Aliases for PFKL Gene
External Ids for PFKL Gene
Previous GeneCards Identifiers for PFKL Gene
This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for PFKL Gene
PFKL (Phosphofructokinase, Liver) is a Protein Coding gene. Among its related pathways are Akt Signaling and Central carbon metabolism in cancer. GO annotations related to this gene include identical protein binding and monosaccharide binding. An important paralog of this gene is PFKM.
UniProtKB/Swiss-Prot for PFKL Gene
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.