Aliases for PFKL Gene
External Ids for PFKL Gene
Previous GeneCards Identifiers for PFKL Gene
This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for PFKL Gene
PFKL (Phosphofructokinase, Liver Type) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include identical protein binding and monosaccharide binding. An important paralog of this gene is PFKM.
UniProtKB/Swiss-Prot for PFKL Gene
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.