Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PFKFB3 Gene

Aliases for PFKFB3 Gene

  • 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 2 3
  • 6PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme 3 4
  • Renal Carcinoma Antigen NY-REN-56 3 4
  • 6PF-2-K/Fru-2,6-P2ase 3 3 4
  • PFK/FBPase 3 3 4
  • IPFK-2 3 4
  • IPFK2 3 6
  • Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 3
  • Fructose-6-Phosphate,2-Kinase/Fructose-2, 6-Bisphosphatase 3
  • 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 3 3
  • 6-Phosphofructo-2-Kinase/ Fructose-2,6-Bisphosphatase 3
  • 6-Phosphofructo-2-Kinase/Fructose-2, 6-Bisphosphatase 3
  • PFK2 3

External Ids for PFKFB3 Gene

Previous GeneCards Identifiers for PFKFB3 Gene

  • GC10P006189
  • GC10P006395
  • GC10P006248
  • GC10P006226
  • GC10P006284
  • GC10P006186

Summaries for PFKFB3 Gene

GeneCards Summary for PFKFB3 Gene

PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) is a Protein Coding gene. Among its related pathways are Akt Signaling and Metabolism. GO annotations related to this gene include fructose-2,6-bisphosphate 2-phosphatase activity and 6-phosphofructo-2-kinase activity. An important paralog of this gene is PFKFB2.

UniProtKB/Swiss-Prot for PFKFB3 Gene

  • Synthesis and degradation of fructose 2,6-bisphosphate

Gene Wiki entry for PFKFB3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFKFB3 Gene

Genomics for PFKFB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PFKFB3 Gene

Start:
6,144,880 bp from pter
End:
6,235,545 bp from pter
Size:
90,666 bases
Orientation:
Plus strand

Genomic View for PFKFB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PFKFB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PFKFB3 Gene

Proteins for PFKFB3 Gene

  • Protein details for PFKFB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16875-F263_HUMAN
    Recommended name:
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
    Protein Accession:
    Q16875
    Secondary Accessions:
    • B7Z955
    • O43622
    • O75902
    • Q5VX15
    • Q5VX18
    • Q5VX19

    Protein attributes for PFKFB3 Gene

    Size:
    520 amino acids
    Molecular mass:
    59609 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PFKFB3 Gene

    Alternative splice isoforms for PFKFB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PFKFB3 Gene

Proteomics data for PFKFB3 Gene at MOPED

Post-translational modifications for PFKFB3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PFKFB3 (PFKFB3)

No data available for DME Specific Peptides for PFKFB3 Gene

Domains for PFKFB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q16875

UniProtKB/Swiss-Prot:

F263_HUMAN :
  • Q16875
Family:
  • In the C-terminal section; belongs to the phosphoglycerate mutase family.
genes like me logo Genes that share domains with PFKFB3: view

No data available for Gene Families for PFKFB3 Gene

Function for PFKFB3 Gene

Molecular function for PFKFB3 Gene

GENATLAS Biochemistry: fructose 2,6-P2 synthesis and degradation,bifunctional enzyme,?,expressed in kidney
UniProtKB/Swiss-Prot CatalyticActivity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate
UniProtKB/Swiss-Prot Function: Synthesis and degradation of fructose 2,6-bisphosphate

Gene Ontology (GO) - Molecular Function for PFKFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003873 6-phosphofructo-2-kinase activity NAS 8830046
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PFKFB3: view

Phenotypes for PFKFB3 Gene

MGI mutant phenotypes for PFKFB3:
inferred from 1 alleles
GenomeRNAi human phenotypes for PFKFB3:
genes like me logo Genes that share phenotypes with PFKFB3: view

Animal Models for PFKFB3 Gene

MGI Knock Outs for PFKFB3:

Animal Model Products

miRNA for PFKFB3 Gene

miRTarBase miRNAs that target PFKFB3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PFKFB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PFKFB3 Gene

Localization for PFKFB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PFKFB3 Gene COMPARTMENTS Subcellular localization image for PFKFB3 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PFKFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PFKFB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PFKFB3 Gene

Pathways for PFKFB3 Gene

genes like me logo Genes that share pathways with PFKFB3: view

Pathways by source for PFKFB3 Gene

2 Qiagen pathways for PFKFB3 Gene
1 Cell Signaling Technology pathway for PFKFB3 Gene
2 BioSystems pathways for PFKFB3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PFKFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006000 fructose metabolic process IEA --
GO:0006003 fructose 2,6-bisphosphate metabolic process IEA --
GO:0006006 glucose metabolic process TAS --
GO:0006096 glycolytic process --
genes like me logo Genes that share ontologies with PFKFB3: view

Compounds for PFKFB3 Gene

(7) HMDB Compounds for PFKFB3 Gene

Compound Synonyms Cas Number PubMed IDs
2-Phosphoglyceric acid
  • 2-(dihydrogen phosphate)Glycerate
2553-59-5
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Not Available
D-Fructose 2,6-bisphosphate
  • D-Fructose 2,6-bisphosphate
Not Available

(19) Novoseek inferred chemical compound relationships for PFKFB3 Gene

Compound -log(P) Hits PubMed IDs
fructose-6-phosphate 79.4 4
fructose 57.4 2
glycerol 3-phosphate 48.1 2
glucose 45.3 13
phosphoenolpyruvate 41.6 3
genes like me logo Genes that share compounds with PFKFB3: view

Transcripts for PFKFB3 Gene

Unigene Clusters for PFKFB3 Gene

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PFKFB3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PFKFB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7: - - -
SP8: - -
SP9: -
SP10:

ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PFKFB3 Gene

GeneLoc Exon Structure for
PFKFB3
ECgene alternative splicing isoforms for
PFKFB3

Expression for PFKFB3 Gene

mRNA expression in normal human tissues for PFKFB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PFKFB3 Gene

This gene is overexpressed in Muscle - Skeletal (10.1), Whole Blood (5.7), and Adipose - Subcutaneous (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PFKFB3 Gene

SOURCE GeneReport for Unigene cluster for PFKFB3 Gene Hs.195471

mRNA Expression by UniProt/SwissProt for PFKFB3 Gene

Q16875-F263_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PFKFB3: view

In Situ Assay Products

Orthologs for PFKFB3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PFKFB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PFKFB3 35
  • 99.42 (n)
  • 99.81 (a)
PFKFB3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PFKFB3 35
  • 90.18 (n)
  • 96.07 (a)
PFKFB3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PFKFB3 35
  • 90.92 (n)
  • 96.38 (a)
PFKFB3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pfkfb3 35
  • 88.34 (n)
  • 97.64 (a)
Pfkfb3 16
Pfkfb3 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PFKFB3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PFKFB3 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pfkfb3 35
  • 88.54 (n)
  • 97.64 (a)
chicken
(Gallus gallus)
Aves PFKFB3 35
  • 80.26 (n)
  • 87.06 (a)
PFKFB3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PFKFB3 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pfkfb3 35
  • 71.29 (n)
  • 79.74 (a)
zebrafish
(Danio rerio)
Actinopterygii pfkfb3 35
  • 71.41 (n)
  • 76.09 (a)
pfkfb3 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pfrx 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K02B2.1 36
  • 51 (a)
ManyToMany
Y110A7A.6 35
  • 56.25 (n)
  • 57.69 (a)
Y110A7A.6 36
  • 53 (a)
ManyToMany
Y110A7A.6b 37
  • 56 (a)
K02B2.1 37
  • 55 (a)
Y110A7A.6a 37
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FBP26 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for PFKFB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PFKFB3 Gene

ENSEMBL:
Gene Tree for PFKFB3 (if available)
TreeFam:
Gene Tree for PFKFB3 (if available)

Paralogs for PFKFB3 Gene

Paralogs for PFKFB3 Gene

genes like me logo Genes that share paralogs with PFKFB3: view

Variants for PFKFB3 Gene

Sequence variations from dbSNP and Humsavar for PFKFB3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs583544 -- 6,184,926(-) TGTGG(C/T)ACGTA intron-variant
rs583586 -- 6,184,893(-) ggctg(A/C/G)ctcac intron-variant
rs583599 -- 6,184,887(-) ctcac(A/G)cctgt intron-variant
rs583934 -- 6,184,880(-) ctgta(A/G)cccca intron-variant
rs584797 -- 6,178,533(-) TCACC(C/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PFKFB3 Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV Loss 18971310
nsv5665 CNV Insertion 18451855
nsv894816 CNV Loss 21882294
nsv894817 CNV Gain 21882294
nsv437656 CNV Loss 16327808
nsv7198 OTHER Inversion 18451855
nsv894818 CNV Gain 21882294
dgv604n71 CNV Gain 21882294
dgv66n27 CNV Gain 19166990
dgv605n71 CNV Gain 21882294
nsv894831 CNV Loss 21882294
nsv894832 CNV Loss 21882294
dgv606n71 CNV Loss 21882294
nsv521145 CNV Loss 19592680
nsv894836 CNV Gain 21882294
esv2626974 CNV Deletion 19546169
nsv525622 CNV Gain 19592680
dgv124n67 CNV Loss 20364138
esv994076 CNV Deletion 20482838
esv2731929 CNV Deletion 23290073
nsv825235 CNV Loss 20364138
nsv512142 CNV Loss 21212237
esv1353057 CNV Deletion 17803354
nsv24567 CNV Loss 16902084
dgv100e201 CNV Deletion 23290073
nsv437094 CNV Loss 16327808
esv271270 CNV Insertion 20981092

Relevant External Links for PFKFB3 Gene

HapMap Linkage Disequilibrium report
PFKFB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFKFB3 Gene

Disorders for PFKFB3 Gene

(6) Novoseek inferred disease relationships for PFKFB3 Gene

Disease -log(P) Hits PubMed IDs
colon adenocarcinoma 45.9 3
cancer 26.8 19
solid tumor 3.29 1
tumors 2.7 8
leukemia 0 1

Relevant External Links for PFKFB3

Genetic Association Database (GAD)
PFKFB3
Human Genome Epidemiology (HuGE) Navigator
PFKFB3
genes like me logo Genes that share disorders with PFKFB3: view

No data available for UniProtKB/Swiss-Prot for PFKFB3 Gene

Publications for PFKFB3 Gene

  1. Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6- bisphosphatase gene (PFKFB3). (PMID: 10072580) Manzano A. … Bartrons R. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  2. The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase (PFKFB3) map position 10p14-p15. (PMID: 9146922) Nicholl J. … Watts C.K. (Chromosome Res. 1997) 2 3 4 23
  3. Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. (PMID: 16316985) Kim S.G. … Lee Y.H. (J. Biol. Chem. 2006) 3 4 23
  4. A direct substrate-substrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. (PMID: 17499765) Kim S.G. … Lee Y.H. (J. Mol. Biol. 2007) 3 4 23
  5. An inducible gene product for 6-phosphofructo-2-kinase with an AU- rich instability element: role in tumor cell glycolysis and the Warburg effect. (PMID: 10077634) Chesney J. … Bucala R. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23

Products for PFKFB3 Gene

Sources for PFKFB3 Gene

Back to Top

Content