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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PFKFB3 Gene

protein-coding GIFtS: 62
GCID: GC10P006186

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Explore 22 diseases affiliated with
PFKFB3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3¹ ²		6-Phosphofructo-2-Kinase/ Fructose-2,6-Bisphosphatase²
Renal Carcinoma Antigen NY-REN-56² ³		6-Phosphofructo-2-Kinase/Fructose-2, 6-Bisphosphatase²
6PF-2-K/Fru-2,6-P2ase 3² ³		6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 3²
6PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme² ³		PFK2²
IPFK-2¹		Fructose-6-Phosphate,2-Kinase/Fructose-2, 6-Bisphosphatase²
PFK/FBPase 3² ³		Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase²
IPFK2² ⁵

External Ids:	HGNC: 8874¹	Entrez Gene: 5209²	Ensembl: ENSG00000170525⁷	OMIM: 605319⁵	UniProtKB: Q16875³

Export aliases for PFKFB3 gene to outside databases

Previous GC identifers: GC10P006189 GC10P006395 GC10P006248 GC10P006226 GC10P006284

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: F263_HUMAN, Q16875

Function: Synthesis and degradation of fructose 2,6-bisphosphate

Gene Wiki entry for PFKFB3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PFKFB3 gene promoter:
USF1 USF-1:USF-2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Arnt c-Ets-1 CREB deltaCREB USF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PFKFB3 promoter sequence

Search SABiosciences Chromatin IP Primers for PFKFB3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15.1

PFKFB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKFB3 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P006186: view genomic region (about GC identifiers)

Start:	6,186,843 bp from pter	End:	6,277,508 bp from pter
Size:	90,666 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F263_HUMAN, Q16875 (See protein sequence)

Recommended Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Size: 520 amino acids; 59609 Da

6/7 PDB 3D structures from and Proteopedia for PFKFB3 (see all 7):

2AXN (3D)

2DWO (3D)

2DWP (3D)

2I1V (3D)

3QPU (3D)

3QPV (3D)

Secondary accessions: O43622 O75902 Q5VX19

Alternative splicing: 2 isoforms: Q16875-1 Q16875-2

Explore the universe of human proteins at neXtProt for PFKFB3: NX_Q16875

Post-translational modifications:

Phosphorylation by AMPK stimulates activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16875

PFKFB3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001138915.1 NP_004557.1

ENSEMBL proteins:

ENSP00000369115 ENSP00000436885 ENSP00000434628 ENSP00000432356 ENSP00000369111

ENSP00000433771 ENSP00000369105 ENSP00000353712 ENSP00000369100 ENSP00000351288

ENSP00000390285 ENSP00000434342 ENSP00000416677 ENSP00000404995 ENSP00000443319

ENSP00000446384 ENSP00000369108

Reactome Protein details: Q16875
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	Uscn Proteins for PFKFB3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

PFKFB3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PFKFB3 for domains About GeneDecksing

5 InterPro domains/families:

IPR016260 Bifunct_6PFK/fruc_bisP_Ptase

IPR001345 PG/BPGM_mutase_AS

IPR003094 6Pfruct_kin

IPR013079 6Phosfructo_kin

IPR013078 His_Pase_superF_clade-1

Graphical View of Domain Structure for InterPro Entry Q16875

ProtoNet protein and cluster: Q16875

2 Blocks protein families:

IPB001345 Phosphoglycerate/bisphosphoglycerate mutase

IPB013079 6-phosphofructo-2-kinase

UniProtKB/Swiss-Prot: F263_HUMAN, Q16875

Similarity: In the C-terminal section; belongs to the phosphoglycerate mutase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: F263_HUMAN, Q16875

Function: Synthesis and degradation of fructose 2,6-bisphosphate

Catalytic activity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate

Catalytic activity: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate

Genatlas biochemistry entry for PFKFB3:

fructose 2,6-P2 synthesis and degradation,bifunctional enzyme,?,expressed in kidney

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		hsa-miR-300 hsa-miR-106a hsa-miR-488 hsa-miR-301a hsa-miR-519a hsa-miR-133a hsa-miR-93 hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: PFKFB3 3' UTR sequence

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0003873	6-phosphofructo-2-kinase activity	NAS	8830046
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	IEA	--
GO:0005524	ATP binding	IEA	--

PFKFB3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PFKFB3:

Decreased 12E8 and total tau p

Animal Models:
Mouse knock-out Pfkfb3^tm1Jche for PFKFB3
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Pfkfb3):

mortality/aging

PFKFB3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glucose metabolism

Glucose metabolism

1.00

Glycolysis

0.44

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

AMPK Enzyme Complex Pathway

AMPK Enzyme Complex Pathway

1.00

Akt Signaling

Akt Signaling

1.00

AMPK signaling

AMPK signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PFKFB3

	AMPK Enzyme Complex Pathway
	Akt Signaling

1 Cell Signaling Technology (CST) Pathway for PFKFB3

Glucose / Energy Metabolism

2 BioSystems Pathways for PFKFB3

	AMPK signaling
	HIF-1-alpha transcription factor network

4 Reactome Pathways for PFKFB3

	Metabolism of carbohydrates
	Metabolism
	Glucose metabolism
	Glycolysis

1 Kegg Pathway (Kegg details for PFKFB3):

Fructose and mannose metabolism

PFKFB3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PFKFB3

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/25 Interacting proteins for PFKFB3 (Q16875³ ENSP00000369100⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CUL2	Q13617³, ENSP00000363880⁴	I2D: score=2 STRING: ENSP00000363880
AKT1	P31749³	I2D: score=1
ARRB1	P49407³	I2D: score=1
ARRB2	P32121³	I2D: score=1
ERBB2IP	Q96RT1³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006000	fructose metabolic process	IEA	--
GO:0006003	fructose 2,6-bisphosphate metabolic process	NAS	--
GO:0006006	glucose metabolic process	TAS	--
GO:0006096	glycolysis	TAS	--

PFKFB3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PFKFB3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PFKFB3

7 HMDB Compounds for PFKFB3 About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Phosphoglyceric acid	2-(dihydrogen phosphate)Glycerate (see all 16)	2553-59-5	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Beta-D-Fructose 6-phosphate	beta-D-Fructose 6-phosphate (see all 2)	--	--
D-Fructose 2,6-bisphosphate	D-Fructose 2,6-bisphosphate (see all 6)	--	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/19 Novoseek chemical compound relationships for PFKFB3 gene (see all 19) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fructose-6-phosphate	79.4	4	1833982 (1), 15994045 (1), 2163613 (1), 8394741 (1)
fructose	57.4	2	20006513 (1), 10072580 (1)
glycerol 3-phosphate	48.1	2	7499445 (1), 8394741 (1)
glucose	45.3	14	19473963 (2), 18039179 (2), 15640157 (1), 19937972 (1) (see all 11)
phosphoenolpyruvate	41.6	3	7499445 (1), 2163613 (1), 8394741 (1)
lactate	36.5	5	16912547 (1), 18202014 (1), 17805487 (1), 2163613 (1) (see all 5)
citrate	34.1	3	10521487 (1), 7499445 (1), 2163613 (1)
atp	32.7	2	18202014 (1), 12417335 (1)
vegf	26.1	5	15640157 (1), 17143338 (1), 15925437 (1), 16311927 (1) (see all 5)
phosphocreatine	25	1	12417335 (1)

Search CenterWatch for drugs/clinical trials and news about PFKFB3 / F263

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PFKFB3 gene (2 alternative transcripts):

NM_001145443.1 NM_004566.3

Unigene Cluster for PFKFB3:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Hs.195471 [show with all ESTs]

Unigene Representative Sequence: NM_004566

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379789(uc001ijd.3 uc010qaw.2 uc009xik.3 uc009xil.3)

ENST00000490474 ENST00000467491 ENST00000477914 ENST00000379785 ENST00000461744

ENST00000317350 ENST00000360521 ENST00000379775(uc001ije.3 uc001ijf.3)

ENST00000358499(uc001ijg.3 uc009xij.3) ENST00000450232 ENST00000487989

ENST00000475881 ENST00000414237 ENST00000441697 ENST00000536985(uc009xii.3)

ENST00000540253 ENST00000379782

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		hsa-miR-300 hsa-miR-106a hsa-miR-488 hsa-miR-301a hsa-miR-519a hsa-miR-133a hsa-miR-93 hsa-miR-526b*

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Additional cDNA sequence:

AF056320.1 AF109735.1 AJ227868.1 AJ272438.1 AJ272439.1 AJ272440.1 AJ295747.1 AK291263.1

AK303039.1 AK304450.1 BC037258.1 BC040482.1 D49817.1 L77662.1

14 DOTS entries:

DT.92439698 DT.92439691 DT.95148380 DT.99995463 DT.100775884 DT.75117867 DT.92439689 DT.91746482

DT.95095678 DT.95377617 DT.121274363 DT.121274440 DT.75138328 DT.95107470

24/213 AceView cDNA sequences (see all 213):

BU193109 BQ003837 BM904874 AW572037 AJ272440 CA389453 AW130192 CK819925

AI567474 BM141854 BE326961 AI952793 AW768640 AW449507 AW471347 AI580224

AI648689 BX642776 BM505274 AW779837 T08556 AJ227868 AJ272439 H88301

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PFKFB3 (see all 10) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^	14a	·	14b	^	15	^
SP1:																									-		-				-				-										-		-
SP2:			-		-		-		-		-														-						-				-						-		-		-		-		-
SP3:																																									-		-		-		-
SP4:
SP5:

ExUns:	16a	·	16b	^	17	^	18a	·	18b	^	19a	·	19b	·	19c	·	19d
SP1:					-				-
SP2:	-		-		-				-
SP3:					-		-		-
SP4:
SP5:					-

ECgene alternative splicing isoforms for PFKFB3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PFKFB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTTTTGGC

About this image

PFKFB3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Cardiac Fibroblasts

Epicardium

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See PFKFB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PFKFB3

SOURCE GeneReport for Unigene cluster: Hs.195471

UniProtKB/Swiss-Prot: F263_HUMAN, Q16875

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including PFKFB3:

Hypoxia Signaling Pathway in human mouse rat

Diabetes in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PFKFB3 gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pfkfb3^{1 , 5}	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more^{1, 5}	88.46(n)¹ 97.69(a)¹		2 (8.73 cM)⁵ 170768¹ NM_133232.3¹ NP_573495.2¹ 11471430⁵
chicken (Gallus gallus)	Aves	PFKFB3¹	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more	80.26(n) 87.06(a)		418247 XM_416472.3 XP_416472.2
lizard (Anolis carolinensis)	Reptilia	PFKFB3⁶	--	77(a)	1 ↔ 1	5(571669-598313)
zebrafish (Danio rerio)	Actinopterygii	BC060925.1²	--	75.97(n)		BC060925.1
fruit fly (Drosophila melanogaster)	Insecta	Pfrx⁶	6-phosphofructo-2-kinase	35(a)	1 → many	X(19389538-19403390)
worm (Caenorhabditis elegans)	Secernentea	Y110A7A.6b³ Y110A7A.6¹	Protein Y110A7A.6¹	56(a) (best of 3)³ 56.22(n)¹ 57.42(a)¹		I(5131526-5133910)³ 172147¹ NM_059128.4¹ NP_491529.2¹
thale cress (Arabidopsis thaliana)	eudicotyledons	F2KP⁶	fructose-2,6-bisphosphatase	25(a)	possible ortholog	1(2178104-2184148)
rice (Oryza sativa)	Liliopsida	-- --	6PF-2-K/Fru-2,6-P2ASE liver isozyme, putative, exp... 6PF-2-K/Fru-2,6-P2ASE liver isozyme, putative, exp...	28(a) 23(a)	possible ortholog possible ortholog	3(10257526-10270089) 5(3763090-3771440)

ENSEMBL Gene Tree for PFKFB3 (if available)
TreeFam Gene Tree for PFKFB3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PFKFB3 gene

PFKFB1² PFKFB2² PFKFB4²

18/126 SIMAP similar genes for PFKFB3 using alignment to 14 protein entries: F263_HUMAN (see all proteins) (see all similar genes):

PFK2 HINFP PACRG SPG7 ZNF620 ADCK1

ARL6IP5 IRF2 FTSJ2 MRPL45 MSH5 NKIRAS2

TUBA1C PTPLAD1 ZNF554 PFKFB4 CDK10 MFSD12

PFKFB3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149205798^1,2	C	--	6182016(+)	`CACAA-/CCCCTCC`	1	--	int¹		0	--	--	--	--
rs5782881^1,2	C,F,	--	6184526(+)	`TGCTGC/-CCATG`	1	--	int¹		5		NA CSA	10
rs1887028^1,2	C,F,A,H,	--	6184858(-)	`CCAAAA/GCCCTT`	1	--	us2k¹		2		WA EA	238
rs943123^1,2	C,H,	--	6184862(-)	`GCTTCT/CAAAAC`	1	--	us2k¹		12		WA NA CSA EA	375
rs943122^1,2	C,F,A,H,	--	6184909(-)	`GGGCCG/ATGGCT`	1	--	us2k¹		4		NS WA NA EA	478
rs943121^1,2	C,F,A,H,	--	6184913(-)	`GATGGG/TGCCGT`	1	--	us2k¹		3		WA NA EA	358
rs139617710^1,2		--	6184961(+)	`GCGGCA/GGTGGC`	1	--	us2k¹		0	--	--	--	--
rs11599116^1,2	C,F,H,	--	6184982(+)	`CAGGCG/AGGATG`	1	--	us2k¹		2		NA	124
rs11593474^1,2	C,F,H,	--	6185016(+)	`TGGCCT/CTGGAT`	1	--	us2k¹		5		NA CSA WA EA	364
rs183599436^1,2		--	6185047(+)	`GTTACA/GTCCAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PFKFB3 (6186843 - 6277508 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for PFKFB3
3 CNVs: 53482 48007 100844
4 Indels: 11455 10676 24532 10675

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PFKFB3 for disorders           About GeneDecksing

OMIM gene information: 605319    OMIM disorders: --

20/22 diseases for PFKFB3 (see all 22):    About MalaCards

renal carcinoma glycogen storage disease carcinoma chronic lymphocytic leukemia

lymphocytic leukemia colon adenocarcinoma renal cell carcinoma ischemia

adenocarcinoma leukemia alzheimer's disease gastric cancer

pancreatic cancer prostate carcinoma astrocytoma pancreatitis

glioblastoma obesity hypoxia prostatitis

6 Novoseek disease relationships for PFKFB3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon adenocarcinoma	45.9	5	12007784 (2), 12384552 (1)
cancer	26.8	21	16115917 (4), 17143338 (3), 12384552 (3), 12963966 (1) (see all 12)
solid tumor	3.29	1	16912547 (1)
tumors	2.7	9	16115917 (3), 12384552 (2), 12963966 (1), 10077634 (1) (see all 5)
leukemia	0	1	16912547 (1)
ischemia	0	3	12392881 (3)

Human Genome Epidemiology (HuGE) Navigator: PFKFB3 (1 document)

Export disorders for PFKFB3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PFKFB3 gene, integrated from 9 sources (see all 105):
(articles sorted by number of sources associating them with PFKFB3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6- bisphosphatase gene (PFKFB3). (PubMed id 10072580)^{1, 2, 3, 9} Manzano A.... Bartrons R. (1998)
An inducible gene product for 6-phosphofructo-2-kinase with an AU- rich instability element: role in tumor cell glycolysis and the Warburg effect. (PubMed id 10077634)^{1, 2, 9} Chesney J.... Bucala R. (1999)
The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase (PFKFB3) map position 10p14-p15. (PubMed id 9146922)^{1, 3, 9} Nicholl J....Watts C.K. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2} Scanlan M.J....Old L.J. (1999)
Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. (PubMed id 8830046)^{1, 2} Sakai A.... Sakakibara R. (1996)
High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. (PubMed id 12384552)^{1, 9} Atsumi T....Bucala R. (2002)
Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. (PubMed id 17143338)^{1, 9} Bobarykina A.Y....Minchenko O.H. (2006)
Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2). (PubMed id 12963966)^{1, 9} Mahlknecht U....Bucala R. (2003)
Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3 ) increases proliferation via cyclin-dependent kinases. (PubMed id 19473963)^{1, 9} Yalcin A....Chesney J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5209	HGNC: 8874	AceView: PFKFB3	Ensembl:ENSG00000170525	euGenes: HUgn5209
ECgene: PFKFB3	Kegg: 5209	H-InvDB: PFKFB3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PFKFB3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PFKFB3 gene
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Patent Information for PFKFB3 gene:
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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

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PFKFB3 Gene

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

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