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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PFKFB3 Gene

protein-coding   GIFtS: 63
GCID: GC10P006186

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 31 2     6-Phosphofructo-2-Kinase/ Fructose-2,6-Bisphosphatase2
Renal Carcinoma Antigen NY-REN-562 3     6-Phosphofructo-2-Kinase/Fructose-2, 6-Bisphosphatase2
6PF-2-K/Fru-2,6-P2ase 32 3     6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 32
6PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme2 3     PFK22
iPFK-22 3     Fructose-6-Phosphate,2-Kinase/Fructose-2, 6-Bisphosphatase2
PFK/FBPase 32 3     Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase2
IPFK22 5     

External Ids:    HGNC: 88741   Entrez Gene: 52092   Ensembl: ENSG000001705257   OMIM: 6053195   UniProtKB: Q168753   

Export aliases for PFKFB3 gene to outside databases

Previous GC identifers: GC10P006189 GC10P006395 GC10P006248 GC10P006226 GC10P006284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PFKFB3 Gene: 
PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) is a protein-coding gene. Diseases associated with PFKFB3 include colon adenocarcinoma, and glycogen storage disease, and among its related super-pathways are Gluconeogenesis and p38 Signaling. GO annotations related to this gene include 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB1.

UniProtKB/Swiss-Prot: F263_HUMAN, Q16875
Function: Synthesis and degradation of fructose 2,6-bisphosphate

Gene Wiki entry for PFKFB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PFKFB3 gene promoter:
         USF1   USF-1:USF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Arnt   c-Ets-1   CREB   deltaCREB   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PFKFB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PFKFB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

PFKFB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKFB3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P006186:  view genomic region     (about GC identifiers)

Start:
6,186,843 bp from pter      End:
6,277,508 bp from pter
Size:
90,666 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F263_HUMAN, Q16875 (See protein sequence)
Recommended Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3  
Size: 520 amino acids; 59609 Da
6/7 PDB 3D structures from and Proteopedia for PFKFB3 (see all 7):
2AXN (3D)        2DWO (3D)        2DWP (3D)        2I1V (3D)        3QPU (3D)        3QPV (3D)    
Secondary accessions: O43622 O75902 Q5VX15 Q5VX19
Alternative splicing: 3 isoforms:  Q16875-1   Q16875-2   Q16875-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for PFKFB3: NX_Q16875

Explore proteomics data for PFKFB3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by AMPK stimulates activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16875

  • PFKFB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PFKFB3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001138915.1  NP_001269559.1  NP_004557.1  

    ENSEMBL proteins: 
     ENSP00000369115   ENSP00000369105   ENSP00000433771   ENSP00000434628   ENSP00000436885  
     ENSP00000432356   ENSP00000369111   ENSP00000353712   ENSP00000369100   ENSP00000390285  
     ENSP00000434342   ENSP00000416677   ENSP00000404995   ENSP00000443319   ENSP00000446384  
     ENSP00000369108  
    Reactome Protein details: Q16875
    Human Recombinant Protein Products for PFKFB3: 
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    Sino Biological Recombinant Protein for PFKFB3
    Sino Biological Cell Lysate for PFKFB3 
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    Cloud-Clone Corp. Proteins for PFKFB3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    PFKFB3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR016260 Bifunct_6PFK/fruc_bisP_Ptase
     IPR001345 PG/BPGM_mutase_AS
     IPR003094 6Pfruct_kin
     IPR013079 6Phosfructo_kin
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q16875

    ProtoNet protein and cluster: Q16875

    2 Blocks protein domains:
    IPB001345 Phosphoglycerate/bisphosphoglycerate mutase
    IPB013079 6-phosphofructo-2-kinase


    UniProtKB/Swiss-Prot: F263_HUMAN, Q16875
    Similarity: In the C-terminal section; belongs to the phosphoglycerate mutase family


    PFKFB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F263_HUMAN, Q16875
    Function: Synthesis and degradation of fructose 2,6-bisphosphate
    Catalytic activity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
    Catalytic activity: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate

         Genatlas biochemistry entry for PFKFB3:
    fructose 2,6-P2 synthesis and degradation,bifunctional enzyme,?,expressed in kidney

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038736-phosphofructo-2-kinase activity NAS8830046
    GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity IEA--
    GO:0005524ATP binding IEA--
         
    PFKFB3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PFKFB3:
     Decreased 12E8 and total tau p 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pfkfb3):
     mortality/aging 

    PFKFB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pfkfb3tm1Jche for PFKFB3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PFKFB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PFKFB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PFKFB3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PFKFB3 

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    hsa-miR-300 hsa-miR-106a hsa-miR-488 hsa-miR-301a hsa-miR-519a hsa-miR-133a hsa-miR-93 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidPFKFB3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PFKFB3 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucose metabolism
    Glucose metabolism0.50
    Glycolysis0.44
    2Akt Signaling
    Akt Signaling0.60
    3MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    4Metabolism
    Metabolism0.40
    5HIF-1-alpha transcription factor network
    HIF-1-alpha transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PFKFB3
        AMPK Enzyme Complex Pathway
    Akt Signaling

    1 Cell Signaling Technology (CST) Pathway for PFKFB3
        Glucose / Energy Metabolism

    2 BioSystems Pathways for PFKFB3
        AMPK signaling
    HIF-1-alpha transcription factor network


    4        Reactome Pathways for PFKFB3
        Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Glycolysis


    2         Kegg Pathways  (Kegg details for PFKFB3):
        Fructose and mannose metabolism
    HIF-1 signaling pathway


    PFKFB3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PFKFB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/31 Interacting proteins for PFKFB3 (Q168753 ENSP000003691004) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006000fructose metabolic process IEA--
    GO:0006003fructose 2,6-bisphosphate metabolic process NAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006096glycolysis TAS--

    PFKFB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PFKFB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PFKFB3 (F263)

    7 HMDB Compounds for PFKFB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Phosphoglyceric acid2-(dihydrogen phosphate)Glycerate (see all 16)2553-59-5--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    D-Fructose 2,6-bisphosphateD-Fructose 2,6-bisphosphate (see all 6)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/19 Novoseek inferred chemical compound relationships for PFKFB3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose-6-phosphate 79.4 4 1833982 (1), 15994045 (1), 2163613 (1), 8394741 (1)
    fructose 57.4 2 20006513 (1), 10072580 (1)
    glycerol 3-phosphate 48.1 2 7499445 (1), 8394741 (1)
    glucose 45.3 14 19473963 (2), 18039179 (2), 15640157 (1), 19937972 (1) (see all 11)
    phosphoenolpyruvate 41.6 3 7499445 (1), 2163613 (1), 8394741 (1)
    lactate 36.5 5 16912547 (1), 18202014 (1), 17805487 (1), 2163613 (1) (see all 5)
    citrate 34.1 3 10521487 (1), 7499445 (1), 2163613 (1)
    atp 32.7 2 18202014 (1), 12417335 (1)
    vegf 26.1 5 15640157 (1), 17143338 (1), 15925437 (1), 16311927 (1) (see all 5)
    phosphocreatine 25 1 12417335 (1)

    Search CenterWatch for drugs/clinical trials and news about PFKFB3 / F263

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PFKFB3 gene (3 alternative transcripts): 
    NM_001145443.1  NM_001282630.1  NM_004566.3  

    Unigene Cluster for PFKFB3:

    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
    Hs.195471  [show with all ESTs]
    Unigene Representative Sequence: NM_004566
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379789(uc001ijd.3 uc010qaw.2 uc009xik.3 uc009xil.3)
    ENST00000317350 ENST00000461744 ENST00000467491 ENST00000490474 ENST00000477914
    ENST00000379785 ENST00000360521 ENST00000379775(uc001ije.3 uc001ijf.3)
    ENST00000450232 ENST00000487989 ENST00000475881 ENST00000414237 ENST00000441697
    ENST00000536985(uc009xii.3) ENST00000540253 ENST00000379782

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    Additional mRNA sequence: 

    AF056320.1 AF109735.1 AJ227868.1 AJ272438.1 AJ272439.1 AJ272440.1 AJ295747.1 AK291263.1 
    AK303039.1 AK304450.1 BC037258.1 BC040482.1 D49817.1 L77662.1 

    15 DOTS entries:

    DT.92439698  DT.92439691  DT.95148380  DT.99995463  DT.100775884  DT.75117867  DT.92439689  DT.91746482 
    DT.95095678  DT.95377617  DT.40112378  DT.121274363  DT.121274440  DT.75138328  DT.95107470 

    24/213 AceView cDNA sequences (see all 213):

    AW471347 AW768640 BE326961 AI952793 AW449507 AJ272440 BQ003837 BU194193 
    AA811308 H88301 T32788 BX642776 AI580224 AJ272439 AJ227868 AI648689 
    AI565523 T08556 BM505274 AW130192 BU193109 AW779837 AW572037 AI567474 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PFKFB3 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
    SP1:                                                                          -     -           -           -                             -     -               
    SP2:        -     -     -     -     -                                         -                 -           -                 -     -     -     -     -         
    SP3:                                                                                                                          -     -     -     -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
    SP1:              -           -                           
    SP2:  -     -     -           -                           
    SP3:              -     -     -                           
    SP4:                                                      
    SP5:              -                                       


    ECgene alternative splicing isoforms for PFKFB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PFKFB3 expression in normal human tissues (normalized intensities)      PFKFB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTTTGGC
    PFKFB3 Expression
    About this image


    PFKFB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Zeugopod Long Bone
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiac Fibroblasts Myocardium
             heart/atrium   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Meckel's Cartilage
             skeleton/cranium/chondrocranium   
     
     Eye (Sensory Organs)
             Retina

    See PFKFB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PFKFB3

    SOURCE GeneReport for Unigene cluster: Hs.195471

    UniProtKB/Swiss-Prot: F263_HUMAN, Q16875
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including PFKFB3: 
              Hypoxia Signaling Pathway in human mouse rat
              Diabetes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PFKFB3 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pfkfb31 , 5 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more1, 5 88.46(n)1
    97.69(a)1
      2 (8.73 cM)5
    1707681  NM_133232.31  NP_573495.21 
     114714305 
    chicken
    (Gallus gallus)
    Aves PFKFB31 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more 80.26(n)
    87.06(a)
      418247  XM_416472.3  XP_416472.2 
    lizard
    (Anolis carolinensis)
    Reptilia PFKFB36
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatas...
    86(a)
    1 ↔ 1
    5(566235-598337)
    zebrafish
    (Danio rerio)
    Actinopterygii BC060925.12   -- 75.97(n)    BC060925.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pfrx6
    6-phosphofructo-2-kinase
    36(a)
    1 → many
    X(19389538-19403390)
    worm
    (Caenorhabditis elegans)
    Secernentea Y110A7A.6b3
    Y110A7A.61
    Protein Y110A7A.61 56(a)
    (best of 3)3
    56.22(n)1
    57.42(a)1
      I(5131526-5133910)3
    1721471  NM_059128.41  NP_491529.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FBP266
    Fructose-2,6-bisphosphatase, required for glucose ...
    43(a)
    1 → many
    X(129285-130643)
    barley
    (Hordeum vulgare)
    Liliopsida AV910103.12   -- 69.6(n)    AV910103.1 


    ENSEMBL Gene Tree for PFKFB3 (if available)
    TreeFam Gene Tree for PFKFB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PFKFB3 gene
    PFKFB12  PFKFB22  PFKFB42  
    18/139 SIMAP similar genes for PFKFB3 using alignment to 13 protein entries:     F263_HUMAN (see all proteins) (see all similar genes):
    PFK2    HINFP    PACRG    PARK2    SPG7    VPS33A
    ZNF620    ZNF114    ADCK1    ARL6IP5    IRF2    FTSJ2
    MRPL45    NKIRAS2    TUBA1C    PTPLAD1    ZNF554    PFKFB4

    PFKFB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2744 SNPs in PFKFB3 are shown (see all 2744)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs353385991,2
    C--6144168(+) TTTTT-/TTTT  
      
    /TTTTT
    AGACG
    1 -- int11NA 2
    rs586496561,2
    C--6153570(+) AAAAA-/A/AAA 
            
    GAAAA
    1 -- int11NA 2
    rs171363991,2
    F--6170226(+) TGGACAAGGAC/-
            
    GAGGT
    2 -- us2k1 int12Minor allele frequency- -:0.17MN EA 356
    rs18870281,2
    C,F,A,H--6184858(-) CCAAAA/GCCCTT 1 -- us2k12Minor allele frequency- G:0.15WA EA 238
    rs9431231,2
    C,H--6184862(-) GCTTCT/CAAAAC 1 -- us2k112Minor allele frequency- C:0.04WA NA CSA EA 375
    rs9431221,2
    C,F,A,H--6184909(-) GGGCCG/ATGGCT 1 -- us2k14Minor allele frequency- A:0.09NS WA NA EA 478
    rs9431211,2
    C,F,A,H--6184913(-) GATGGG/TGCCGT 1 -- us2k13Minor allele frequency- T:0.14WA NA EA 358
    rs1396177101,2
    C--6184961(+) GCGGCA/GGTGGC 1 -- us2k10--------
    rs115991161,2
    C,F,H--6184982(+) CAGGCG/AGGATG 1 -- us2k12Minor allele frequency- A:0.13NA 124
    rs115934741,2
    C,F,H--6185016(+) TGGCCT/CTGGAT 1 -- us2k15Minor allele frequency- C:0.09NA CSA WA EA 364

    HapMap Linkage Disequilibrium report for PFKFB3 (6186843 - 6277508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for PFKFB3 (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv994076CNV Deletion20482838
    dgv100e201CNV Deletion23290073
    esv2626974CNV Deletion19546169
    esv1353057CNV Deletion17803354
    esv2731929CNV Deletion23290073
    esv271270CNV Insertion20981092
    nsv5665CNV Insertion18451855
    nsv437094CNV Loss16327808
    nsv894816CNV Loss21882294
    dgv124n67CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605319    OMIM disorders: --

    19 diseases for PFKFB3:    About MalaCards
    colon adenocarcinoma    glycogen storage disease    ischemia    astrocytoma
    hypoxia    adenocarcinoma    chronic lymphocytic leukemia    glioblastoma
    renal cell carcinoma    obesity    pancreatic cancer    gastric cancer
    leukemia    alzheimer's disease    pancreatitis    prostatitis
    hepatitis    endotheliitis    neuronitis


    PFKFB3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for PFKFB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon adenocarcinoma 45.9 5 12007784 (2), 12384552 (1)
    cancer 26.8 21 16115917 (4), 17143338 (3), 12384552 (3), 12963966 (1) (see all 12)
    solid tumor 3.29 1 16912547 (1)
    tumors 2.7 9 16115917 (3), 12384552 (2), 12963966 (1), 10077634 (1) (see all 5)
    leukemia 0 1 16912547 (1)
    ischemia 0 3 12392881 (3)

    Genetic Association Database (GAD): PFKFB3
    Human Genome Epidemiology (HuGE) Navigator: PFKFB3 (1 document)

    Export disorders for PFKFB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PFKFB3 gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with PFKFB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6- bisphosphatase gene (PFKFB3). (PubMed id 10072580)1, 2, 3, 9 Manzano A.... Bartrons R. (1998)
    2. An inducible gene product for 6-phosphofructo-2-kinase with an AU- rich instability element: role in tumor cell glycolysis and the Warburg effect. (PubMed id 10077634)1, 2, 9 Chesney J.... Bucala R. (1999)
    3. The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase (PFKFB3) map position 10p14-p15. (PubMed id 9146922)1, 3, 9 Nicholl J....Watts C.K. (1997)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    7. Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. (PubMed id 8830046)1, 2 Sakai A.... Sakakibara R. (1996)
    8. High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. (PubMed id 12384552)1, 9 Atsumi T....Bucala R. (2002)
    9. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. (PubMed id 17143338)1, 9 Bobarykina A.Y....Minchenko O.H. (2006)
    10. Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2). (PubMed id 12963966)1, 9 Mahlknecht U....Bucala R. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5209 HGNC: 8874 AceView: PFKFB3 Ensembl:ENSG00000170525 euGenes: HUgn5209
    ECgene: PFKFB3 Kegg: 5209 H-InvDB: PFKFB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PFKFB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PFKFB3 gene:
    Search GeneIP for patents involving PFKFB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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