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Aliases for PFKFB3 Gene

Aliases for PFKFB3 Gene

  • 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 2 3 5
  • 6PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme 3 4
  • Renal Carcinoma Antigen NY-REN-56 3 4
  • 6PF-2-K/Fru-2,6-P2ase 3 3 4
  • PFK/FBPase 3 3 4
  • IPFK-2 3 4
  • Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 3
  • Fructose-6-Phosphate,2-Kinase/Fructose-2, 6-Bisphosphatase 3
  • 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 3 3
  • 6-Phosphofructo-2-Kinase/ Fructose-2,6-Bisphosphatase 3
  • IPFK2 3
  • PFK2 3

External Ids for PFKFB3 Gene

Previous GeneCards Identifiers for PFKFB3 Gene

  • GC10P006189
  • GC10P006395
  • GC10P006248
  • GC10P006226
  • GC10P006284
  • GC10P006186

Summaries for PFKFB3 Gene

Entrez Gene Summary for PFKFB3 Gene

  • The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

GeneCards Summary for PFKFB3 Gene

PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) is a Protein Coding gene. Among its related pathways are AMPK Enzyme Complex Pathway and AMPK signaling pathway. GO annotations related to this gene include 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB2.

UniProtKB/Swiss-Prot for PFKFB3 Gene

  • Synthesis and degradation of fructose 2,6-bisphosphate.

Gene Wiki entry for PFKFB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFKFB3 Gene

Genomics for PFKFB3 Gene

Regulatory Elements for PFKFB3 Gene

Enhancers for PFKFB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PFKFB3 on UCSC Golden Path with GeneCards custom track

Promoters for PFKFB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PFKFB3 Gene

Chromosome:
10
Start:
6,144,880 bp from pter
End:
6,235,545 bp from pter
Size:
90,666 bases
Orientation:
Plus strand

Genomic View for PFKFB3 Gene

Genes around PFKFB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PFKFB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PFKFB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PFKFB3 Gene

Proteins for PFKFB3 Gene

  • Protein details for PFKFB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16875-F263_HUMAN
    Recommended name:
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
    Protein Accession:
    Q16875
    Secondary Accessions:
    • B7Z955
    • O43622
    • O75902
    • Q5VX15
    • Q5VX18
    • Q5VX19

    Protein attributes for PFKFB3 Gene

    Size:
    520 amino acids
    Molecular mass:
    59609 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PFKFB3 Gene

    Alternative splice isoforms for PFKFB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PFKFB3 Gene

Post-translational modifications for PFKFB3 Gene

No data available for DME Specific Peptides for PFKFB3 Gene

Domains & Families for PFKFB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q16875

UniProtKB/Swiss-Prot:

F263_HUMAN :
  • In the C-terminal section; belongs to the phosphoglycerate mutase family.
Family:
  • In the C-terminal section; belongs to the phosphoglycerate mutase family.
genes like me logo Genes that share domains with PFKFB3: view

Function for PFKFB3 Gene

Molecular function for PFKFB3 Gene

GENATLAS Biochemistry:
fructose 2,6-P2 synthesis and degradation,bifunctional enzyme,?,expressed in kidney
UniProtKB/Swiss-Prot CatalyticActivity:
Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
UniProtKB/Swiss-Prot Function:
Synthesis and degradation of fructose 2,6-bisphosphate.

Gene Ontology (GO) - Molecular Function for PFKFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003873 6-phosphofructo-2-kinase activity NAS 8830046
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PFKFB3: view
genes like me logo Genes that share phenotypes with PFKFB3: view

Animal Models for PFKFB3 Gene

MGI Knock Outs for PFKFB3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PFKFB3

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PFKFB3 Gene

Localization for PFKFB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PFKFB3 Gene COMPARTMENTS Subcellular localization image for PFKFB3 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PFKFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PFKFB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PFKFB3 Gene

Pathways & Interactions for PFKFB3 Gene

genes like me logo Genes that share pathways with PFKFB3: view

Pathways by source for PFKFB3 Gene

1 Cell Signaling Technology pathway for PFKFB3 Gene

SIGNOR curated interactions for PFKFB3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PFKFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006000 fructose metabolic process IEA --
GO:0006003 fructose 2,6-bisphosphate metabolic process IEA --
GO:0007420 brain development IEA --
GO:0016311 dephosphorylation IEA --
GO:0046835 carbohydrate phosphorylation IEA --
genes like me logo Genes that share ontologies with PFKFB3: view

Drugs & Compounds for PFKFB3 Gene

(15) Drugs for PFKFB3 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
2-Phosphoglyceric acid Experimental Pharma 0
PFK-015 Pharma PFKFB3 inhibitor, potent and selective 0

(16) Additional Compounds for PFKFB3 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
D-Fructose 2,6-bisphosphate
  • b-D-Fructose 2,6-bisphosphate
  • beta-D-Fructose 2,6-bisphosphate
  • D-Fructose 2,6-bisphosphate
  • Fru 2,6-P2, Fructose 2,6-diphosphate
  • Fructose 2,6-bisphosphate
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
643-13-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(3) Tocris Compounds for PFKFB3 Gene

Compound Action Cas Number
3PO PFKFB3 inhibitor 13309-08-5
PFK 15 Selective PFKFB3 inhibitor 4382-63-2
YZ9 PFKFB3 inhibitor 6093-71-6

(1) ApexBio Compounds for PFKFB3 Gene

Compound Action Cas Number
PFK-015 PFKFB3 inhibitor, potent and selective 4382-63-2
genes like me logo Genes that share compounds with PFKFB3: view

Transcripts for PFKFB3 Gene

Unigene Clusters for PFKFB3 Gene

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PFKFB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7: - - -
SP8: - -
SP9: -
SP10:

ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PFKFB3 Gene

GeneLoc Exon Structure for
PFKFB3
ECgene alternative splicing isoforms for
PFKFB3

Expression for PFKFB3 Gene

mRNA expression in normal human tissues for PFKFB3 Gene

mRNA differential expression in normal tissues according to GTEx for PFKFB3 Gene

This gene is overexpressed in Muscle - Skeletal (x10.1), Whole Blood (x5.7), and Adipose - Subcutaneous (x4.4).

Protein differential expression in normal tissues from HIPED for PFKFB3 Gene

This gene is overexpressed in Plasma (18.1), Heart (13.6), Spleen (10.6), and Peripheral blood mononuclear cells (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PFKFB3 Gene



Protein tissue co-expression partners for PFKFB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PFKFB3 Gene:

PFKFB3

SOURCE GeneReport for Unigene cluster for PFKFB3 Gene:

Hs.195471

mRNA Expression by UniProt/SwissProt for PFKFB3 Gene:

Q16875-F263_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PFKFB3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PFKFB3 Gene

Orthologs for PFKFB3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PFKFB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PFKFB3 34
  • 90.18 (n)
  • 96.07 (a)
PFKFB3 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PFKFB3 34
  • 90.92 (n)
  • 96.38 (a)
PFKFB3 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pfkfb3 34
  • 88.34 (n)
  • 97.64 (a)
Pfkfb3 16
Pfkfb3 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PFKFB3 34
  • 99.42 (n)
  • 99.81 (a)
PFKFB3 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pfkfb3 34
  • 88.54 (n)
  • 97.64 (a)
oppossum
(Monodelphis domestica)
Mammalia PFKFB3 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PFKFB3 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PFKFB3 34
  • 80.26 (n)
  • 87.06 (a)
PFKFB3 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PFKFB3 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pfkfb3 34
  • 71.29 (n)
  • 79.74 (a)
zebrafish
(Danio rerio)
Actinopterygii pfkfb3 34
  • 71.41 (n)
  • 76.09 (a)
pfkfb3 35
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pfrx 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K02B2.1 36
  • 55 (a)
Y110A7A.6a 36
  • 55 (a)
Y110A7A.6b 36
  • 56 (a)
Y110A7A.6 34
  • 56.25 (n)
  • 57.69 (a)
K02B2.1 35
  • 51 (a)
ManyToMany
Y110A7A.6 35
  • 53 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FBP26 35
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 63 (a)
OneToMany
Species where no ortholog for PFKFB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PFKFB3 Gene

ENSEMBL:
Gene Tree for PFKFB3 (if available)
TreeFam:
Gene Tree for PFKFB3 (if available)

Paralogs for PFKFB3 Gene

Paralogs for PFKFB3 Gene

genes like me logo Genes that share paralogs with PFKFB3: view

Variants for PFKFB3 Gene

Sequence variations from dbSNP and Humsavar for PFKFB3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs583544 -- 6,184,926(-) TGTGG(C/T)ACGTA intron-variant
rs583586 -- 6,184,893(-) ggctg(A/C/G)ctcac intron-variant
rs583599 -- 6,184,887(-) ctcac(A/G)cctgt intron-variant
rs583934 -- 6,184,880(-) ctgta(A/G)cccca intron-variant
rs584797 -- 6,178,533(-) TCACC(C/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PFKFB3 Gene

Variant ID Type Subtype PubMed ID
dgv124n67 CNV loss 20364138
dgv1e49 CNV loss 18971310
dgv66n27 CNV gain 19166990
dgv88e201 CNV deletion 23290073
dgv949n54 CNV gain 21841781
esv1353057 CNV deletion 17803354
esv2626974 CNV deletion 19546169
esv2731929 CNV deletion 23290073
esv3306994 CNV mobile element insertion 20981092
esv3401171 CNV insertion 20981092
esv3438991 CNV insertion 20981092
esv3545839 CNV deletion 23714750
esv3622241 CNV gain 21293372
esv3622242 CNV gain 21293372
esv3622243 CNV loss 21293372
esv994076 CNV deletion 20482838
nsv1072583 CNV deletion 25765185
nsv1136109 CNV deletion 24896259
nsv24567 CNV deletion 16902084
nsv437094 CNV loss 16327808
nsv437656 CNV loss 16327808
nsv512142 CNV loss 21212237
nsv521145 CNV loss 19592680
nsv525622 CNV gain 19592680
nsv5665 CNV insertion 18451855
nsv7198 OTHER inversion 18451855
nsv825235 CNV loss 20364138
nsv958544 CNV deletion 24416366

Variation tolerance for PFKFB3 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PFKFB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PFKFB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFKFB3 Gene

Disorders for PFKFB3 Gene

Relevant External Links for PFKFB3

Genetic Association Database (GAD)
PFKFB3
Human Genome Epidemiology (HuGE) Navigator
PFKFB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PFKFB3

No disorders were found for PFKFB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PFKFB3 Gene

Publications for PFKFB3 Gene

  1. Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6- bisphosphatase gene (PFKFB3). (PMID: 10072580) Manzano A. … Bartrons R. (Cytogenet. Cell Genet. 1998) 2 3 4 22 65
  2. The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase (PFKFB3) map position 10p14-p15. (PMID: 9146922) Nicholl J. … Watts C.K. (Chromosome Res. 1997) 2 3 4 22 65
  3. Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: transition state and the C-terminal function. (PMID: 22275052) Cavalier M.C. … Lee Y.H. (Proteins 2012) 2 3 4 65
  4. A direct substrate-substrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. (PMID: 17499765) Kim S.G. … Lee Y.H. (J. Mol. Biol. 2007) 3 4 22 65
  5. Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. (PMID: 16316985) Kim S.G. … Lee Y.H. (J. Biol. Chem. 2006) 3 4 22 65

Products for PFKFB3 Gene

Sources for PFKFB3 Gene

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