Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PFKFB2 Gene

protein-coding   GIFtS: 63
GCID: GC01P207226

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 21 2     6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 22
6PF-2-K/Fru-2,6-P2ase Heart-Type Isozyme2 3     PFK-2/FBPase-22
6PF-2-K/Fru-2,6-P2ase 22 3     Fructose-2,6-Bisphosphatase, Cardiac Isozyme2
PFK/FBPase 22 3     PFKFB, Cardiac2

External Ids:    HGNC: 88731   Entrez Gene: 52082   Ensembl: ENSG000001238367   OMIM: 1718355   UniProtKB: O608253   

Export aliases for PFKFB2 gene to outside databases

Previous GC identifers: GC01P205886 GC01P202936 GC01P203870 GC01P204310 GC01P203616 GC01P205293 GC01P177923


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PFKFB2 Gene:
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a
regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase
activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity
that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate
levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate
levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PFKFB2 Gene: 
PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2) is a protein-coding gene. Diseases associated with PFKFB2 include acute lymphoblastic leukemia, and meningioma, and among its related super-pathways are Gluconeogenesis and p38 Signaling. GO annotations related to this gene include protein kinase binding and 6-phosphofructo-2-kinase activity. An important paralog of this gene is PFKFB3.

UniProtKB/Swiss-Prot: F262_HUMAN, O60825
Function: Synthesis and degradation of fructose 2,6-bisphosphate

Gene Wiki entry for PFKFB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PFKFB2 gene promoter:
         E2F-4   E2F-3a   E2F-5   HTF   Nkx2-5   E2F-2   E2F-1   E2F   HSF2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPFKFB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PFKFB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q31-q32.2

PFKFB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKFB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207226:  view genomic region     (about GC identifiers)

Start:
207,222,801 bp from pter      End:
207,254,369 bp from pter
Size:
31,569 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F262_HUMAN, O60825 (See protein sequence)
Recommended Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2  
Size: 505 amino acids; 58477 Da
Subunit: Homodimer (By similarity)
Secondary accessions: O60824 Q5VVQ3 Q5VVQ4 Q9H3P1
Alternative splicing: 2 isoforms:  O60825-1   O60825-2   

Explore the universe of human proteins at neXtProt for PFKFB2: NX_O60825

Explore proteomics data for PFKFB2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by AMPK stimulates activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60825

  • PFKFB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PFKFB2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001018063.1  NP_006203.2  

    ENSEMBL proteins: 
     ENSP00000356047   ENSP00000356046   ENSP00000439420   ENSP00000408717   ENSP00000440878  
    Reactome Protein details: O60825
    Human Recombinant Protein Products for PFKFB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PFKFB2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PFKFB2
    GenScript Custom Purified and Recombinant Proteins Services for PFKFB2
    Novus Biologicals PFKFB2 Proteins
    Novus Biologicals PFKFB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PFKFB2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    PFKFB2 for ontologies           About GeneDecksing



    PFKFB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PFKFB2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PFKFB2
    GenScript Custom Superior Antibodies Services for PFKFB2
    Novus Biologicals PFKFB2 Antibodies
    Abcam antibodies for PFKFB2
    Cloud-Clone Corp. Antibodies for PFKFB2 
    ThermoFisher Antibodies for PFKFB2
    LSBio Antibodies in human, mouse, rat for PFKFB2 

    Assay Products for PFKFB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PFKFB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PFKFB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PFKFB2 
    Cloud-Clone Corp. CLIAs for PFKFB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR016260 Bifunct_6PFK/fruc_bisP_Ptase
     IPR001345 PG/BPGM_mutase_AS
     IPR003094 6Pfruct_kin
     IPR013079 6Phosfructo_kin
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O60825

    ProtoNet protein and cluster: O60825

    2 Blocks protein domains:
    IPB001345 Phosphoglycerate/bisphosphoglycerate mutase
    IPB013079 6-phosphofructo-2-kinase


    UniProtKB/Swiss-Prot: F262_HUMAN, O60825
    Similarity: In the C-terminal section; belongs to the phosphoglycerate mutase family


    PFKFB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F262_HUMAN, O60825
    Function: Synthesis and degradation of fructose 2,6-bisphosphate
    Catalytic activity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
    Catalytic activity: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate
    Enzyme regulation: Phosphorylation results in the activation of the kinase activity

         Genatlas biochemistry entry for PFKFB2:
    fructose 2,6-P2 synthesis and degradation,bifunctional enzyme,expressed in heart

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038736-phosphofructo-2-kinase activity IDA11069105
    GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity IEA--
    GO:0005515protein binding IPI8387495
    GO:0005524ATP binding IEA--
    GO:0019900kinase binding ----
         
    PFKFB2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PFKFB2:
     Decreased viability  Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PFKFB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PFKFB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PFKFB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PFKFB2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PFKFB2
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate PFKFB2 (see all 50):
    hsa-miR-596 hsa-miR-607 hsa-miR-631 hsa-miR-548l hsa-miR-3916 hsa-miR-1304 hsa-miR-1184 hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PFKFB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PFKFB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PFKFB2
    Sirion Biotech Customized adenovirus for overexpression of PFKFB2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PFKFB2 (see all 11)
    OriGene ORF clones in mouse, rat for PFKFB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PFKFB2 (NM_006212)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PFKFB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKFB2
    Sirion Biotech Customized lentivirus for stable overexpression of PFKFB2 
                         Customized lentivirus expression plasmids for stable overexpression of PFKFB2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PFKFB2
    Search LifeMap BioReagents cell lines for PFKFB2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PFKFB2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucose metabolism
    Glucose metabolism0.50
    Glycolysis0.44
    2Akt Signaling
    Akt Signaling0.60
    3MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    4Metabolism
    Metabolism0.40
    5HIF-1 signaling pathway
    HIF-1 signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PFKFB2
        AMPK Enzyme Complex Pathway
    Akt Signaling

    4        Reactome Pathways for PFKFB2
        Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Glycolysis


    2         Kegg Pathways  (Kegg details for PFKFB2):
        Fructose and mannose metabolism
    HIF-1 signaling pathway


    PFKFB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PFKFB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/44 Interacting proteins for PFKFB2 (O608252, 3 ENSP000003560474) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3304235 I2D: score=3 STRING: ENSP00000309503
    GCKP355573, ENSP000002233664I2D: score=2 STRING: ENSP00000223366
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    AKT1P317493, ENSP000002702024I2D: score=2 STRING: ENSP00000270202
    YWHAQP273483, ENSP000002380814I2D: score=3 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006000fructose metabolic process IEA--
    GO:0006003fructose 2,6-bisphosphate metabolic process IEA--
    GO:0006006glucose metabolic process TAS--
    GO:0006007glucose catabolic process ----

    PFKFB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PFKFB2 (F262)

    7 HMDB Compounds for PFKFB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Phosphoglyceric acid2-(dihydrogen phosphate)Glycerate (see all 16)2553-59-5--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    D-Fructose 2,6-bisphosphateD-Fructose 2,6-bisphosphate (see all 6)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PFKFB2 / F262

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PFKFB2 gene (2 alternative transcripts): 
    NM_001018053.1  NM_006212.2  

    Unigene Cluster for PFKFB2:

    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
    Hs.282702  [show with all ESTs]
    Unigene Representative Sequence: NM_006212
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367080(uc001hfg.3 uc009xcc.3) ENST00000464777 ENST00000468857
    ENST00000367079(uc010psc.2 uc001hfh.3 uc010psd.2) ENST00000473310
    ENST00000483688 ENST00000545806 ENST00000411990 ENST00000541914
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PFKFB2
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate PFKFB2 (see all 50):
    hsa-miR-596 hsa-miR-607 hsa-miR-631 hsa-miR-548l hsa-miR-3916 hsa-miR-1304 hsa-miR-1184 hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PFKFB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PFKFB2
    Clone
    Products:
         
    OriGene clones in human, mouse for PFKFB2 (see all 11)
    OriGene ORF clones in mouse, rat for PFKFB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PFKFB2 (NM_006212)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PFKFB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKFB2
    Sirion Biotech Customized lentivirus for stable overexpression of PFKFB2 
                         Customized lentivirus expression plasmids for stable overexpression of PFKFB2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PFKFB2
    OriGene qSTAR qPCR primer pairs in human, mouse for PFKFB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PFKFB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PFKFB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PFKFB2

    Additional mRNA sequence: 

    AB044805.1 AF470623.1 AJ005578.1 AK125661.1 AK292883.1 AK295367.1 AK302315.1 BC069350.1 
    BC069385.1 BC069583.1 BC069586.1 BC069600.1 BC075075.2 BC075076.2 BC112103.1 BC112105.1 
    CR749442.1 EU334168.1 

    9 DOTS entries:

    DT.210707  DT.107542  DT.91809420  DT.121390148  DT.121390177  DT.100744114  DT.121390179  DT.91981428 
    DT.442688 

    24/135 AceView cDNA sequences (see all 135):

    AA454131 AW299854 CF529880 BC075075 AI190288 AA621500 AI335906 AI631267 
    BC069600 AA912185 C02436 BF061553 BE464268 CB117291 BC069583 CF528902 
    BQ002833 AA233959 BQ108611 BX504976 AA446436 BQ705993 AI813916 AA026248 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PFKFB2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
    SP1:                          -                                                                 -                             -               
    SP2:                          -                                                                 -                                             
    SP3:                                                                                            -     -     -                 -               
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for PFKFB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PFKFB2 expression in normal human tissues (normalized intensities)      PFKFB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PFKFB2 Expression
    About this image


    PFKFB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/ventricle   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See PFKFB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PFKFB2

    SOURCE GeneReport for Unigene cluster: Hs.282702

    UniProtKB/Swiss-Prot: F262_HUMAN, O60825
    Tissue specificity: Heart

        SABiosciences Custom PCR Arrays for PFKFB2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PFKFB2
    OriGene qSTAR qPCR primer pairs in human, mouse for PFKFB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PFKFB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PFKFB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PFKFB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PFKFB2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pfkfb21 , 5 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more1, 5 89.8(n)1
    93.2(a)1
      1 (56.89 cM)5
    186401  NM_008825.41  NP_032851.21 
     1306890435 
    chicken
    (Gallus gallus)
    Aves PFKFB21 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more 78.3(n)
    89.72(a)
      419850  XM_417979.3  XP_417979.2 
    lizard
    (Anolis carolinensis)
    Reptilia PFKFB26
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343228.1(2114584-2150754)
    zebrafish
    (Danio rerio)
    Actinopterygii BC050514.12   -- 75.65(n)   393983  BC050514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pfrx6
    6-phosphofructo-2-kinase
    37(a)
    1 → many
    X(19389538-19403390)
    worm
    (Caenorhabditis elegans)
    Secernentea Y110A7A.6b3   -- 55(a)
    (best of 3)
      I(5131526-5133910)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FBP261 Fbp26p 51.59(n)
    49.39(a)
      853286   NP_012380.1 


    ENSEMBL Gene Tree for PFKFB2 (if available)
    TreeFam Gene Tree for PFKFB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PFKFB2 gene
    PFKFB32  PFKFB12  PFKFB42  
    4 SIMAP similar genes for PFKFB2 using alignment to 4 protein entries:     F262_HUMAN (see all proteins):
    DKFZp781D2217    PFKFB3    PFKFB4    PFKFB1

    PFKFB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/647 SNPs in PFKFB2 are shown (see all 647)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119178671,2
    C--207228331(+) CTGTTC/TTTGGG 2 -- int10--------
    rs1161514101,2
    C,F--207228452(+) TTGTAC/TACACA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs786858871,2
    F--207228791(+) TTGCGA/CGGAGA 2 -- int11Minor allele frequency- C:0.03WA 118
    rs2021953991,2
    --207228985(+) AGTGG-/TTTTATA 2 -- int10--------
    rs716937011,2
    C--207228987(+) TATATTA/-ATATA 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs345907251,2
    C--207229008(+) ATATA-/TA    
       
    /TATA
    GCCAG
    2 -- int10--------
    rs1878433241,2
    --207229054(+) ACAGCC/TGACCA 2 -- int10--------
    rs596050131,2
    C--207229070(+) AGACCA/GGGAAT 2 -- int10--------
    rs1406891401,2
    --207229107(+) AGCCTC/GGACCT 2 -- int10--------
    rs1498604411,2
    C--207229450(+) AATACG/TAACAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for PFKFB2 (207222801 - 207254369 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PFKFB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526699CNV Loss19592680
    nsv832426CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PFKFB2
    DNA2.0 Custom Variant and Variant Library Synthesis for PFKFB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 171835    OMIM disorders: --

    11 diseases for PFKFB2:    About MalaCards
    acute lymphoblastic leukemia    meningioma    lymphoblastic leukemia    hypoxia
    schizophrenia    pancreatic cancer    gastric cancer    pancreatitis
    prostate cancer    leukemia    prostatitis


    PFKFB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PFKFB2
    Human Genome Epidemiology (HuGE) Navigator: PFKFB2 (4 documents)

    Export disorders for PFKFB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PFKFB2 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with PFKFB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and structure of the human 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). (PubMed id 9652401)1, 2, 9 Heine-Suner D....Rodriguez de Cordoba S. (1998)
    2. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    3. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Isolation of novel heart-specific genes using the BodyMap database. (PubMed id 11374908)1, 2 Soejima H.... Mukai T. (2001)
    8. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. (PubMed id 11069105)1, 2 Marsin A.S....Hue L. (2000)
    9. A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells. (PubMed id 18039179)1, 9 Arden C....Agius L. (2008)
    10. Akt-dependent activation of the heart 6-phosphofructo- 2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids. (PubMed id 23457334)1 Novellasdemunt L....Rosa J.L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5208 HGNC: 8873 AceView: PFKFB2 Ensembl:ENSG00000123836 euGenes: HUgn5208
    ECgene: PFKFB2 Kegg: 5208 H-InvDB: PFKFB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PFKFB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PFKFB2 gene:
    Search GeneIP for patents involving PFKFB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PFKFB2
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PFKFB2  
     OriGene qPCR primer pairs and template standards for PFKFB2   OriGene Protein Over-expression Lysate for PFKFB2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PFKFB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PFKFB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PFKFB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PFKFB2   OriGene Custom Protein Services for PFKFB2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PFKFB2
     QIAGEN SeqTarget long-range PCR primers for resequencing PFKFB2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PFKFB2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PFKFB2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PFKFB2
     GenScript Custom Purified and Recombinant Proteins Services for PFKFB2 GenScript cDNA clones with any tag delivered in your preferred vector for PFKFB2
     GenScript Custom Assay Services for PFKFB2 GenScript Custom Superior Antibodies Services for PFKFB2
     GenScript Custom overexpressing Cell Line Services for PFKFB2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PFKFB2 promoter
     Search Chromatin IP Primers for PFKFB2
     RT2 qPCR Primer Assay in human, mouse, rat PFKFB2
     GNC Network for PFKFB2
     SABiosciences PCR Arrays including human, mouse, rat PFKFB2
     Search Tocris compounds for PFKFB2 (F262)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PFKFB2 antibodies
     PFKFB2 proteins
     PFKFB2 lysates
     Antibodies for PFKFB2
     See all of Abcam's Antibodies, Kits and Proteins for PFKFB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PFKFB2
     Antibodies for PFKFB2
     ELISAs for PFKFB2
     CLIAs for PFKFB2
     Search LifeMap BioReagents cell lines for PFKFB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PFKFB2
     SwitchGear Promoter luciferase reporter plasmids for PFKFB2
     ThermoFisher Antibodies for PFKFB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKFB2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PFKFB2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PFKFB2
    Customized:
     lentivirus for stable overexpression of PFKFB2
     lentivirus expression plasmids for stable overexpression of PFKFB2
     adenovirus for overexpression of PFKFB2
     LSBio Antibodies in human, mouse, rat for PFKFB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PFKFB2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4