PFKFB2 Gene
protein-coding GIFtS: 61
GCID: GC01P207226
|
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
| |
Aliases
for PFKFB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 21 2 | | 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 22 | | 6PF-2-K/Fru-2,6-P2ase Heart-Type Isozyme2 3 | | PFK-2/FBPase-22 | | 6PF-2-K/Fru-2,6-P2ase 22 3 | | Fructose-2,6-Bisphosphatase, Cardiac Isozyme2 | | PFK/FBPase 22 3 | | PFKFB, Cardiac2 |
Export aliases for PFKFB2 gene to outside databasesPrevious GC identifers: GC01P205886 GC01P202936 GC01P203870 GC01P204310 GC01P203616 GC01P205293 GC01P177923 |
Summaries
for PFKFB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PFKFB2:
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, aregulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinaseactivity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity thatcatalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in theheart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver andmuscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been foundfor this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: F262_HUMAN, O60825Function: Synthesis and degradation of fructose 2,6-bisphosphate
Gene Wiki entry for PFKFB2
|
Genomic Views
for PFKFB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PFKFB2 gene promoter:
E2F-4 E2F-3a E2F-5 HTF Nkx2-5 E2F-2 E2F-1 E2F HSF2 Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PFKFB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q31 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q31-q32.2PFKFB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P207226: view genomic region
(about GC identifiers)
Start:
|
207,222,801 bp from pter |
End:
|
207,254,369 bp from pter |
Size:
|
31,569 bases |
Orientation:
|
plus strand |
|
Proteins
for PFKFB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F262_HUMAN, O60825 (See
protein sequence)Recommended Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Size: 505 amino acids; 58477 Da
Subunit: Homodimer (By similarity)
Secondary accessions: O60824 Q5VVQ3 Q5VVQ4 Q9H3P1Alternative splicing: 2 isoforms: O60825-1 O60825-2 Explore the universe of human proteins at neXtProt for PFKFB2: NX_O60825
Post-translational modifications:
Phosphorylation by AMPK stimulates activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60825
PFKFB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001018063.1 NP_006203.2
ENSEMBL proteins: ENSP00000356047 ENSP00000356046 ENSP00000439420 ENSP00000408717 ENSP00000440878 Reactome Protein details: O60825
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PFKFB2 for ontologies About GeneDecksing
PFKFB2 Antibody Products:
Assay Products for PFKFB2: |
Protein
Domains /
Families
for PFKFB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PFKFB2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60825ProtoNet protein and cluster: O60825 2 Blocks protein families: IPB001345 Phosphoglycerate/bisphosphoglycerate mutase IPB013079 6-phosphofructo-2-kinase
UniProtKB/Swiss-Prot: F262_HUMAN, O60825Similarity: In the C-terminal section; belongs to the phosphoglycerate mutase family |
Function
for PFKFB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: F262_HUMAN, O60825Function: Synthesis and degradation of fructose 2,6-bisphosphateCatalytic activity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphateCatalytic activity: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphateEnzyme regulation: Phosphorylation results in the activation of the kinase activity Genatlas biochemistry entry for PFKFB2:fructose 2,6-P2 synthesis and degradation,bifunctional enzyme,expressed in heart
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PFKFB2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for PFKFB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKFB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
PFKFB2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PFKFB2:
|
Pathways & Interactions
for PFKFB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glucose metabolism | | | 2 | AMPK Enzyme Complex Pathway | | | 3 | Akt Signaling | | | 4 | Fructose and mannose metabolism | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PFKFB2
4 
Reactome Pathways for PFKFB2
1 
Kegg Pathway (Kegg details for PFKFB2):
PFKFB2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PFKFB2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/44 Interacting proteins for PFKFB2 (O608252, 3 ENSP000003560474) via UniProtKB, MINT, STRING, and/or I2D (see all 44)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0006000 | fructose metabolic process |
IEA | -- | | GO:0006003 | fructose 2,6-bisphosphate metabolic process |
IEA | -- | | GO:0006006 | glucose metabolic process |
TAS | -- | | GO:0006007 | glucose catabolic process |
-- | -- |
PFKFB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PFKFB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PFKFB2
7 HMDB Compounds for PFKFB2 About this table
Search CenterWatch for drugs/clinical trials and news about PFKFB2 / F262
|
Transcripts
for PFKFB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PFKFB2 gene (2 alternative transcripts): NM_001018053.1 NM_006212.2 Unigene Cluster for PFKFB2: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Hs.282702 [show with all ESTs]Unigene Representative Sequence: NM_0062129 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367080(uc001hfg.3 uc009xcc.3) ENST00000464777 ENST00000468857
ENST00000367079(uc010psc.2 uc001hfh.3 uc010psd.2) ENST00000473310
ENST00000483688 ENST00000545806 ENST00000411990 ENST00000541914
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PFKFB2 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PFKFB2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PFKFB2 (NM_006212) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PFKFB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKFB2 |
Additional cDNA sequence: AB044805.1 AF470623.1 AJ005578.1 AK125661.1 AK292883.1 AK295367.1 AK302315.1 BC069350.1 BC069385.1 BC069583.1 BC069586.1 BC069600.1 BC075075.2 BC075076.2 BC112103.1 BC112105.1 CR749442.1 EU334168.1 9 DOTS entries: DT.210707 DT.107542 DT.91809420 DT.121390148 DT.121390177 DT.100744114 DT.121390179 DT.91981428 DT.442688 24/135 AceView cDNA sequences (see all 135): BF061553 BC069600 BC069583 AA912185 BQ108611 CB117291 BC075075 AI631267 BQ002833 AI335906 AA454131 C02436 AW299854 AI190288 AA621500 CF529880 AA026248 AK125661 BX504976 CF528902 BC075076 BE464268 AA233959 AW592432
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PFKFB2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PFKFB2
|
Expression
for PFKFB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PFKFB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PFKFB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PFKFB2
SOURCE GeneReport for Unigene cluster: Hs.282702
UniProtKB/Swiss-Prot: F262_HUMAN, O60825Tissue specificity: Heart
SABiosciences Custom PCR Arrays for PFKFB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PFKFB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PFKFB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PFKFB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PFKFB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB2 |
Orthologs
for PFKFB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PFKFB2 gene from 8/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PFKFB21 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more |
78.3(n)
89.72(a) |
|
419850 XM_417979.3 XP_417979.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PFKFB26 |
-- |
84(a) |
1 ↔ 1 |
GL343228.1(2115350-2141552) |
zebrafish
(Danio rerio) |
Actinopterygii |
BC050514.12 |
-- |
75.65(n) |
|
393983 BC050514.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pfrx6 |
6-phosphofructo-2-kinase |
38(a) |
1 → many |
X(19389538-19403390) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y110A7A.6b3 |
-- |
55(a)
(best of 3) |
|
I(5131526-5133910) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
FBP261 |
Fbp26p |
51.59(n)
49.39(a) |
|
853286 NP_012380.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
F2KP6 |
fructose-2,6-bisphosphatase |
25(a) |
possible ortholog |
1(2178104-2184148) |
rice
(Oryza sativa) |
Liliopsida |
---- |
6PF-2-K/Fru-2,6-P2ASE liver isozyme, putative, exp...6PF-2-K/Fru-2,6-P2ASE liver isozyme, putative, exp... |
28(a)23(a) |
possible orthologpossible ortholog |
3(10257526-10270089) 5(3763090-3771440) |
ENSEMBL Gene Tree for PFKFB2 (if available)
TreeFam Gene Tree for PFKFB2 (if available) |
Paralogs
for PFKFB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PFKFB2 gene
- PFKFB32 PFKFB12 PFKFB42
4 SIMAP similar genes for PFKFB2 using alignment to 4 protein entries: F262_HUMAN (see all proteins):DKFZp781D2217 PFKFB3 PFKFB4 PFKFB1
PFKFB2 for paralogs About GeneDecksing
|
Genomic Variants
for PFKFB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PFKFB2 (207222801 - 207254369 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PFKFB2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PFKFB2 |
|
Disorders
/ Diseases
for PFKFB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PFKFB2 for disorders About GeneDecksing
OMIM gene information: 171835
OMIM disorders: --
11  diseases for PFKFB2: About MalaCardsacute lymphoblastic leukemia lymphoblastic leukemia gastric cancer meningioma
pancreatic cancer leukemia prostate cancer pancreatitis
hypoxia prostatitis schizophrenia
Human Genome Epidemiology (HuGE) Navigator: PFKFB2 (4 documents)
Export disorders for PFKFB2 gene to outside databases
|
Publications
for PFKFB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PFKFB2 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with PFKFB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence and structure of the human 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). (PubMed id 9652401)1, 2, 9 Heine-Suner D....Rodriguez de Cordoba S. (1998)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation of novel heart-specific genes using the BodyMap database. (PubMed id 11374908)1, 2 Soejima H.... Mukai T. (2001)
- Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. (PubMed id 11069105)1, 2 Marsin A.S....Hue L. (2000)
- A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells. (PubMed id 18039179)1, 9 Arden C....Agius L. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Upregulation of heart PFK-2/FBPase-2 isozyme in skelet al muscle after persistent contraction. (PubMed id 22241065)1 Rovira J....Cusso R. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for PFKFB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PFKFB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PFKFB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PFKFB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PFKFB2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PFKFB2 gene:
Search GeneIP for patents involving PFKFB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PFKFB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PFKFB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PFKFB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PFKFB2 | | | OriGene Protein Over-expression Lysate for PFKFB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PFKFB2 | | OriGene 3'-UTR Clone for PFKFB2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PFKFB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PFKFB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PFKFB2 | | OriGene Custom Protein Services for PFKFB2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PFKFB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PFKFB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PFKFB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PFKFB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PFKFB2 |
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| | | | Search Tocris compounds for PFKFB2 |
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 | | | PFKFB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB2 |
|  |  |  | | | | ThermoFisher Antibodies for PFKFB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFKFB2 |
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