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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PFKFB1 Gene

protein-coding GIFtS: 66
GCID: GC0XM054976

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

(Previous symbol: PFRX)

Explore 4 diseases affiliated with
PFKFB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1¹ ²		PFK/FBPase 1² ³
PFRX¹ ² ³ ⁵		6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 1²
6PF-2-K/Fru-2,6-P2ase Liver Isozyme² ³		HL2K²
6PF-2-K/Fru-2,6-P2ase 1² ³		Fructose-6-Phosphate,2-Kinase:Fructose-2,6-Bisphosphatase¹
F6PK² ³

External Ids:	HGNC: 8872¹	Entrez Gene: 5207²	Ensembl: ENSG00000158571⁷	OMIM: 311790⁵	UniProtKB: P16118³

Export aliases for PFKFB1 gene to outside databases

Previous GC identifers: GC0XM051811 GC0XM052897 GC0XM053564 GC0XM053926 GC0XM054842 GC0XM052011

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PFKFB1:

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes.

The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using

independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of

the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this

enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found

for this gene. (provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: F261_HUMAN, P16118

Function: Synthesis and degradation of fructose 2,6-bisphosphate

Gene Wiki entry for PFKFB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011630.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PFKFB1 gene promoter:
E2F-4 E2F-3a E2F-5 RP58 E2F-1 E2F Chx10 E2F-2 POU3F2 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PFKFB1 promoter sequence

Search SABiosciences Chromatin IP Primers for PFKFB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.21

PFKFB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKFB1 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM054976: view genomic region (about GC identifiers)

Start:	54,959,394 bp from pter	End:	55,024,967 bp from pter
Size:	65,574 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F261_HUMAN, P16118 (See protein sequence)

Recommended Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

Size: 471 amino acids; 54681 Da

Subunit: Homodimer

1 PDB 3D structure from and Proteopedia for PFKFB1:

1K6M (3D)

Secondary accessions: B2RA88 Q5JXS5 Q99951

Explore the universe of human proteins at neXtProt for PFKFB1: NX_P16118

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16118

PFKFB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001258733.1 NP_001258734.1 NP_002616.2

ENSEMBL proteins:

ENSP00000364145 ENSP00000444074 ENSP00000364131

Reactome Protein details: P16118
Human Recombinant Protein Products for PFKFB1:

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	Uscn Proteins for PFKFB1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	IDA	12379646

PFKFB1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PFKFB1 for domains About GeneDecksing

5 InterPro domains/families:

IPR016260 Bifunct_6PFK/fruc_bisP_Ptase

IPR001345 PG/BPGM_mutase_AS

IPR003094 6Pfruct_kin

IPR013079 6Phosfructo_kin

IPR013078 His_Pase_superF_clade-1

Graphical View of Domain Structure for InterPro Entry P16118

ProtoNet protein and cluster: P16118

2 Blocks protein families:

IPB001345 Phosphoglycerate/bisphosphoglycerate mutase

IPB013079 6-phosphofructo-2-kinase

UniProtKB/Swiss-Prot: F261_HUMAN, P16118

Similarity: In the C-terminal section; belongs to the phosphoglycerate mutase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: F261_HUMAN, P16118

Function: Synthesis and degradation of fructose 2,6-bisphosphate

Catalytic activity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate

Catalytic activity: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate

Enzyme regulation: Phosphorylation results in inhibition of the kinase activity

Genatlas biochemistry entry for PFKFB1:

fructose 2,6-P2 synthesis and degradation,bifunctional enzyme,expressed in liver,activated by the binding of HNF3

(A,B,G) to the glucocorticoid response unit (GRU) antagonized by the binding of HNF6 to the gene (GRU)

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003873	6-phosphofructo-2-kinase activity	TAS	12379646
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	TAS	--
GO:0005515	protein binding	IPI	11522786
GO:0005524	ATP binding	IEA	--
GO:0019900	kinase binding	IEA	--

PFKFB1 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for PFKFB1:

Decreased cell number, increas

Decreased focal adhesion (FA)

Decreased viability

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PFKFB1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glucose metabolism

	Glucose metabolism	1.00			Glycolysis	0.44
	Gluconeogenesis	0.50

PKA-mediated phosphorylation of key metabolic factors

PKA-mediated phosphorylation of key metabolic factors

1.00

Metabolism

Metabolism

1.00

AMPK Enzyme Complex Pathway

AMPK Enzyme Complex Pathway

1.00

Akt Signaling

Akt Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PFKFB1

	AMPK Enzyme Complex Pathway
	Akt Signaling

5/8 Reactome Pathways for PFKFB1 (see all 8)

	Gluconeogenesis
	PP2A-mediated dephosphorylation of key metabolic factors
	Metabolism of carbohydrates
	PKA-mediated phosphorylation of key metabolic factors
	Metabolism

1 Kegg Pathway (Kegg details for PFKFB1):

Fructose and mannose metabolism

PFKFB1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PFKFB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for PFKFB1 (P16118^{1, 2, 3} ENSP00000364145⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GCK	P35557¹^,³, ENSP00000223366⁴	EBI-709807,EBI-709928 I2D: score=1 STRING: ENSP00000223366
PASK	Q96RG2²^,³, ENSP00000234040⁴	MINT-8145447 I2D: score=1 STRING: ENSP00000234040
MAPK3	P27361³, ENSP00000263025⁴	I2D: score=2 STRING: ENSP00000263025
FBP1	ENSP00000364475⁴	STRING: ENSP00000364475
FBP2	ENSP00000364486⁴	STRING: ENSP00000364486

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006000	fructose metabolic process	IEA	--
GO:0006003	fructose 2,6-bisphosphate metabolic process	IDA	2837207
GO:0006006	glucose metabolic process	TAS	--
GO:0006094	gluconeogenesis	TAS	--

PFKFB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PFKFB1

8 HMDB Compounds for PFKFB1 About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Phosphoglyceric acid	2-(dihydrogen phosphate)Glycerate (see all 16)	2553-59-5	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Beta-D-Fructose 6-phosphate	beta-D-Fructose 6-phosphate (see all 2)	--	--
D-Fructose 2,6-bisphosphate	D-Fructose 2,6-bisphosphate (see all 6)	--	--
Fructose 6-phosphate	D-Fructose 6-phosphate (see all 13)	643-13-0	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

5 DrugBank Compounds for PFKFB1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
3-Phosphoglycerol	--	--	target	--	17139284 17016423 10592235
D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate	--	--	target	--	17139284 17016423 10592235
Fructose-6-Phosphate	--	--	target	--	17139284 17016423 10592235
Guanosine-5'-Triphosphate	--	86-01-1	target	--	17139284 17016423 10592235
Phosphothiophosphoric Acid-Adenylate Ester	--	--	target	--	17139284 17016423

Search CenterWatch for drugs/clinical trials and news about PFKFB1 / F261

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PFKFB1 gene (3 alternative transcripts):

NM_001271804.1 NM_001271805.1 NM_002625.3

Unigene Cluster for PFKFB1:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Hs.444304 [show with all ESTs]

Unigene Representative Sequence: NM_002625

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375006(uc004dty.1 uc010nkd.1) ENST00000545676(uc011mol.1)

ENST00000374992

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Additional cDNA sequence:

AK300724.1 AK314089.1 BC096077.1 BC096078.2 BC096079.3 JQ425694.1 JQ425695.1 M19938.1

NR_073450.1 X52638.1

4 DOTS entries:

DT.408513 DT.412060 DT.121317561 DT.406752

8 AceView cDNA sequences:

BX282257 H47320 NM_002625 X52638 M19938 AL703826 T62884 H47404

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PFKFB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAGGACCA

About this image

PFKFB1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Limb

Hindlimb Ventral Muscle

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PFKFB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PFKFB1

SOURCE GeneReport for Unigene cluster: Hs.444304

UniProtKB/Swiss-Prot: F261_HUMAN, P16118

Tissue specificity: Liver

SABiosciences Custom PCR Arrays for PFKFB1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFKFB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PFKFB1 gene from 8/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PFKFB4¹	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more	74.01(n) 80.99(a)		415906 NM_001030584.1 NP_001025755.1
lizard (Anolis carolinensis)	Reptilia	PFKFB1⁶	--	85(a)	1 ↔ 1	1(205678970-205697031)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15996²	Xenopus laevis transcribed sequence with moderate similarity more	78.11(n)		CA788288.1
zebrafish (Danio rerio)	Actinopterygii	wufi11h10²	wufi11h10	76.91(n)		327453 BC044142.1
fruit fly (Drosophila melanogaster)	Insecta	Pfrx⁶	6-phosphofructo-2-kinase	38(a)	1 → many	X(19389538-19403390)
worm (Caenorhabditis elegans)	Secernentea	Y110A7A.6b³	--	55(a) (best of 3)		I(5131526-5133910) --
thale cress (Arabidopsis thaliana)	eudicotyledons	F2KP⁶	fructose-2,6-bisphosphatase	25(a)	possible ortholog	1(2178104-2184148)
rice (Oryza sativa)	Liliopsida	AK069285.1²	--	70.58(n)		AK069285.1

ENSEMBL Gene Tree for PFKFB1 (if available)
TreeFam Gene Tree for PFKFB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PFKFB1 gene

PFKFB3² PFKFB2² PFKFB4²

4 SIMAP similar genes for PFKFB1 using alignment to 6 protein entries: F261_HUMAN (see all proteins):

DKFZp781D2217 PFKFB2 PFKFB4 PFKFB3

PFKFB1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186401279^1,2		--	54959247(+)	`GTCAGA/GGGACT`	1	--	ds500¹		0	--	--	--	--
rs58250891^1,2	C	--	54959366(+)	`CCTGAA/GTATAA`	1	--	ds500¹		1		WA	2
rs5960056^1,2	C	--	54959498(+)	`TCACCG/CATTCC`	1	--	ds500¹		1		CSA	1
rs200184147^1,2		--	54959733(+)	`TGGGG-/TTGCCT`	1	--	ut3¹		0	--	--	--	--
rs148727575^1,2		--	54959763(+)	`TAGGAG/TAAGAG`	1	--	ut3¹		0	--	--	--	--
rs191209655^1,2	C	--	54959833(+)	`GAAAGC/GGCTCA`	1	--	ut3¹		0	--	--	--	--
rs56361408^1,2	C	--	54959921(+)	`TAATAA/GGAAGG`	1	--	int¹		0	--	--	--	--
rs183328823^1,2		--	54959966(+)	`CTCTTC/GTCTTC`	1	--	int¹		0	--	--	--	--
rs188793182^1,2		--	54960135(+)	`TTGCTC/TCATCT`	1	--	int¹		0	--	--	--	--
rs201730176^1,2		--	54960280(+)	`GTTCAC/TGGCCT`	2	M V	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PFKFB1 (54959394 - 55024967 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PFKFB1
1 CNV: 23256
Locus Specific Mutation Databases (LSDB): PFKFB1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PFKFB1 for disorders           About GeneDecksing

OMIM gene information: 311790    OMIM disorders: --

4 diseases for PFKFB1:    About MalaCards

gastric cancer pancreatic cancer pancreatitis hepatitis

Human Genome Epidemiology (HuGE) Navigator: PFKFB1 (1 document)
Tumor Gene Database (TGDB): PFKFB1

Export disorders for PFKFB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PFKFB1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with PFKFB1)

Utopia: connect your pdf to the dynamic
world of online information

Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21. (PubMed id 9119406)^{1, 3, 9} Batra R.S....Craig I.W. (1997)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase. (PubMed id 2163524)^{1, 2} Lange A.J. and Pilkis S.J. (1990)
Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase. (PubMed id 2837207)^{1, 2} Algaier J. and Uyeda K. (1988)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Perioperative genomic profiles using structure-specif ic oligonucleotide probes. (PubMed id 19474452)¹ Hogan K.J....Domanico M.J. (2009)
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)¹ Wang J....He F. (2008)
Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5207	HGNC: 8872	AceView: PFKFB1	Ensembl:ENSG00000158571	euGenes: HUgn5207
ECgene: PFKFB1	Kegg: 5207	H-InvDB: PFKFB1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PFKFB1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PFKFB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PFKFB1 gene:
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GeneCards and IP:
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PFKFB1 Gene

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

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