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Aliases for PFDN6 Gene

Aliases for PFDN6 Gene

  • Prefoldin Subunit 6 2 3
  • HLA Class II Region Expressed Gene KE2 2 3
  • HKE2 3 4
  • PFD6 3 4
  • Prefoldin 6 2
  • KE2 Protein 3
  • Protein Ke2 4
  • H2-KE2 3
  • KE-2 3

External Ids for PFDN6 Gene

Previous Symbols for PFDN6 Gene

  • HKE2

Summaries for PFDN6 Gene

Entrez Gene Summary for PFDN6 Gene

  • PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]

GeneCards Summary for PFDN6 Gene

PFDN6 (Prefoldin Subunit 6) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include unfolded protein binding and chaperone binding.

UniProtKB/Swiss-Prot for PFDN6 Gene

  • Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Wiki entry for PFDN6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFDN6 Gene

Genomics for PFDN6 Gene

Genomic Location for PFDN6 Gene

Start:
33,289,302 bp from pter
End:
33,298,401 bp from pter
Size:
9,100 bases
Orientation:
Plus strand

Genomic View for PFDN6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PFDN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for PFDN6 Gene

Proteins for PFDN6 Gene

  • Protein details for PFDN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15212-PFD6_HUMAN
    Recommended name:
    Prefoldin subunit 6
    Protein Accession:
    O15212
    Secondary Accessions:

    Protein attributes for PFDN6 Gene

    Size:
    129 amino acids
    Molecular mass:
    14583 Da
    Quaternary structure:
    • Heterohexamer of two PFD-alpha type and four PFD-beta type subunits

neXtProt entry for PFDN6 Gene

Proteomics data for PFDN6 Gene at MOPED

Post-translational modifications for PFDN6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys15, Lys66, and Lys88

Other Protein References for PFDN6 Gene

No data available for DME Specific Peptides for PFDN6 Gene

Domains for PFDN6 Gene

Protein Domains for PFDN6 Gene

UniProtKB/Swiss-Prot:

PFD6_HUMAN
Family:
  • Belongs to the prefoldin subunit beta family.:
    • O15212
genes like me logo Genes that share domains with PFDN6: view

No data available for Gene Families for PFDN6 Gene

Function for PFDN6 Gene

Molecular function for PFDN6 Gene

UniProtKB/Swiss-Prot Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Ontology (GO) - Molecular Function for PFDN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0051082 unfolded protein binding NAS 9630229
GO:0051087 chaperone binding IDA 9630229
genes like me logo Genes that share ontologies with PFDN6: view

miRNA for PFDN6 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PFDN6 Gene

Localization for PFDN6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PFDN6 Gene COMPARTMENTS Subcellular localization image for PFDN6 gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PFDN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016272 prefoldin complex IDA 9630229
genes like me logo Genes that share ontologies with PFDN6: view

Pathways for PFDN6 Gene

genes like me logo Genes that share pathways with PFDN6: view

Gene Ontology (GO) - Biological Process for PFDN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
GO:0051131 chaperone-mediated protein complex assembly IDA 9630229
genes like me logo Genes that share ontologies with PFDN6: view

Transcripts for PFDN6 Gene

Unigene Clusters for PFDN6 Gene

Prefoldin subunit 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PFDN6 Gene

No ASD Table

Relevant External Links for PFDN6 Gene

GeneLoc Exon Structure for
PFDN6
ECgene alternative splicing isoforms for
PFDN6

Expression for PFDN6 Gene

mRNA expression in normal human tissues for PFDN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PFDN6 Gene

SOURCE GeneReport for Unigene cluster for PFDN6 Gene Hs.446374

genes like me logo Genes that share expressions with PFDN6: view

Orthologs for PFDN6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PFDN6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PFDN6 36
  • 99.74 (n)
  • 100 (a)
PFDN6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PFDN6 36
  • 90.96 (n)
  • 99.22 (a)
PFDN6 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PFDN6 36
  • 93.54 (n)
  • 99.22 (a)
PFDN6 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2-Ke2 36
  • 90.48 (n)
  • 100 (a)
H2-Ke2 16
H2-Ke2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PFDN6 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pfdn6 36
  • 90.48 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 76 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pfdn6 36
  • 67.23 (n)
  • 67.23 (a)
zebrafish
(Danio rerio)
Actinopterygii pfdn6 36
  • 68.63 (n)
  • 76.47 (a)
pfdn6 37
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012235 36
  • 53.39 (n)
  • 40.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7770 36
  • 53.57 (n)
  • 49.11 (a)
CG7770 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pfd-6 37
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKE2 37
  • 45 (a)
OneToOne
YKE2 39
YKE2 39
thale cress
(Arabidopsis thaliana)
eudicotyledons PFD6 36
  • 50.14 (n)
  • 44.35 (a)
rice
(Oryza sativa)
Liliopsida Os02g0246300 36
  • 50.14 (n)
  • 41.74 (a)
Species with no ortholog for PFDN6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PFDN6 Gene

ENSEMBL:
Gene Tree for PFDN6 (if available)
TreeFam:
Gene Tree for PFDN6 (if available)

Paralogs for PFDN6 Gene

Selected SIMAP similar genes for PFDN6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PFDN6: view

No data available for Paralogs for PFDN6 Gene

Variants for PFDN6 Gene

Structural Variations from Database of Genomic Variants (DGV) for PFDN6 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv830635 CNV Loss 17160897

Relevant External Links for PFDN6 Gene

HapMap Linkage Disequilibrium report
PFDN6

No data available for Sequence variations from dbSNP and Humsavar for PFDN6 Gene

Disorders for PFDN6 Gene

Relevant External Links for PFDN6

Genetic Association Database (GAD)
PFDN6
Human Genome Epidemiology (HuGE) Navigator
PFDN6
genes like me logo Genes that share disorders with PFDN6: view

No data available for UniProtKB/Swiss-Prot for PFDN6 Gene

Publications for PFDN6 Gene

  1. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg J.A. … Trowsdale J. (J. Mol. Biol. 1998) 2 3 4
  2. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PMID: 9630229) Vainberg I.E. … Cowan N.J. (Cell 1998) 2 3 4
  3. Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. (PMID: 17257322) Ostrov D.A. … Iczkowski K.A. (Tissue Antigens 2007) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49

Products for PFDN6 Gene

Sources for PFDN6 Gene

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