Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PFDN6 Gene

protein-coding   GIFtS: 57
GCID: GC06P033257

Prefoldin Subunit 6

(Previous names: HLA class II region expressed gene KE2, prefoldin 6)
(Previous symbol: HKE2)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Prefoldin Subunit 61 2     H2-KE22
HKE21 2 3     KE-22
HLA Class II Region Expressed Gene KE21 2     KE2 Protein2
PFD62 3     Protein Ke23
Prefoldin 61     

External Ids:    HGNC: 49261   Entrez Gene: 104712   Ensembl: ENSG000002042207   OMIM: 6056605   UniProtKB: O152123   

Export aliases for PFDN6 gene to outside databases

Previous GC identifers: GC06P033366 GC06P032999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PFDN6 Gene:
PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha-
and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic
chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 (PubMed 10209023)).(supplied by OMIM,
Jul 2010)

GeneCards Summary for PFDN6 Gene:
PFDN6 (prefoldin subunit 6) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding.

UniProtKB/Swiss-Prot: PFD6_HUMAN, O15212
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent
polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative
proteins

Gene Wiki entry for PFDN6 (Prefoldin subunit 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  NT_167248.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PFDN6 gene promoter:
         Sp1   p53   AP-1   ATF-2   Olf-1   HNF-4alpha2   CUTL1   SREBP-1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPFDN6 promoter sequence
   Search Chromatin IP Primers for PFDN6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PFDN6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

PFDN6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFDN6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033257:  view genomic region     (about GC identifiers)

Start:
33,257,079 bp from pter      End:
33,266,178 bp from pter
Size:
9,100 bases      Orientation:
plus strand

4 alternative locations:
Chr6+,NT_167247 4,731,122-4,732,455      Chr6+,NT_167245 4,538,704-4,540,037      Chr6+,NT_113891.2 4,701,192-4,702,525     
Chr6+,NT_167248 4,489,621-4,490,954     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PFD6_HUMAN, O15212 (See protein sequence)
Recommended Name: Prefoldin subunit 6  
Size: 129 amino acids; 14583 Da
Subunit: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits

Explore the universe of human proteins at neXtProt for PFDN6: NX_O15212

Explore proteomics data for PFDN6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15, Lys66, Lys88
  • Modification sites at PhosphoSitePlus

  • See PFDN6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001172110.1  NP_001252524.1  NP_001252525.1  NP_055075.1  

    ENSEMBL proteins: 
     ENSP00000378563   ENSP00000363734   ENSP00000363738   ENSP00000420135   ENSP00000363735  
    Reactome Protein details: O15212

    PFDN6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PFDN6
    OriGene Protein Over-expression Lysate for PFDN6
    OriGene MassSpec for PFDN6
    OriGene Custom Protein Services for PFDN6
    GenScript Custom Purified and Recombinant Proteins Services for PFDN6
    Novus Biologicals PFDN6 Proteins
    Novus Biologicals PFDN6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PFDN6
    Cloud-Clone Corp. Proteins for PFDN6

     
    Search eBioscience for Proteins for PFDN6 

     
    antibodies-online proteins for PFDN6 (4 products) 

     
    antibodies-online peptides for PFDN6

    PFDN6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PFDN6
    OriGene Custom Antibody Services for PFDN6
    Novus Biologicals PFDN6 Antibodies
    Abcam antibodies for PFDN6
    Cloud-Clone Corp. Antibodies for PFDN6
    ThermoFisher Antibodies for PFDN6
    LSBio Antibodies in human, mouse, rat for PFDN6
    antibodies-online antibodies for PFDN6 (9 products) 

    PFDN6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PFDN6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PFDN6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PFDN6
    Cloud-Clone Corp. CLIAs for PFDN6
    Search eBioscience for ELISAs for PFDN6 
    antibodies-online kits for PFDN6 (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR002777 PFD_beta-like
     IPR009053 Prefoldin

    Graphical View of Domain Structure for InterPro Entry O15212

    ProtoNet protein and cluster: O15212

    1 Blocks protein domain: IPB002777 Prefoldin-related KE2 protein

    UniProtKB/Swiss-Prot: PFD6_HUMAN, O15212
    Similarity: Belongs to the prefoldin subunit beta family


    Find genes that share domains with PFDN6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PFD6_HUMAN, O15212
    Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent
    polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative
    proteins

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0051082unfolded protein binding NAS9630229
    GO:0051087chaperone binding IDA9630229
         
    Find genes that share ontologies with PFDN6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PFDN6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PFDN6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PFDN6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PFDN6

    miRNA
    Products:
        
    miRTarBase miRNAs that target PFDN6:
    hsa-mir-92a-3p (MIRT049091), hsa-mir-106b-5p (MIRT044258), hsa-mir-320a (MIRT044826), hsa-mir-615-3p (MIRT040317)

    Block miRNA regulation of human, mouse, rat PFDN6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PFDN6:
    hsa-miR-22 hsa-miR-144 hsa-miR-558 hsa-miR-139-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PFDN6
    Predesigned siRNA for gene silencing in human, mouse, rat PFDN6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PFDN6

    Clone
    Products:
         
    OriGene clones in human, mouse for PFDN6 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PFDN6 (NM_014260)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PFDN6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFDN6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PFDN6
    Browse ESI BIO Cell Lines and PureStem Progenitors for PFDN6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFDN6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016272prefoldin complex IDA9630229

    Find genes that share ontologies with PFDN6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PFDN6 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Protein folding0.91
    Chaperonin-mediated protein folding0.91
    2Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with PFDN6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PFDN6
        Prefoldin mediated transfer of substrate to CCT/TriC


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PFDN6
    Interactions:

        Search GeneGlobe Interaction Network for PFDN6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PFDN6 (O152122, 3 ENSP000003637344) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48383 I2D: score=2 
    PPP2CBP627143, ENSP000002211384I2D: score=2 STRING: ENSP00000221138
    PRPF4O431723, ENSP000003633134I2D: score=2 STRING: ENSP00000363313
    WRAP73Q9P2S53, ENSP000002707084I2D: score=2 STRING: ENSP00000270708
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--
    GO:0051131chaperone-mediated protein complex assembly IDA9630229

    Find genes that share ontologies with PFDN6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PFDN6 (PFD6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PFDN6 gene (4 alternative transcripts): 
    NM_001185181.2  NM_001265595.1  NM_001265596.1  NM_014260.3  

    Unigene Cluster for PFDN6:

    Prefoldin subunit 6
    Hs.446374  [show with all ESTs]
    Unigene Representative Sequence: BM912978
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395131 ENST00000374606(uc003odt.1 uc010jup.1 uc021ywk.1)
    ENST00000395134 ENST00000374610 ENST00000491382 ENST00000463584 ENST00000374607

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PFDN6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PFDN6:
    hsa-miR-22 hsa-miR-144 hsa-miR-558 hsa-miR-139-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PFDN6
    Predesigned siRNA for gene silencing in human, mouse, rat PFDN6
    Clone
    Products:
         
    OriGene clones in human, mouse for PFDN6 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PFDN6 (NM_014260)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PFDN6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFDN6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PFDN6
    OriGene qSTAR qPCR primer pairs in human, mouse for PFDN6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PFDN6
      QuantiTect SYBR Green Assays in human, mouse, rat PFDN6
      QuantiFast Probe-based Assays in human, mouse, rat PFDN6

    Additional mRNA sequence: 

    AK312150.1 BC039033.1 BC059783.1 

    15 DOTS entries:

    DT.318123  DT.100780052  DT.100780055  DT.112317  DT.100822238  DT.100780054  DT.100805106  DT.92443803 
    DT.100780053  DT.95274858  DT.95340994  DT.121364794  DT.95376362  DT.100709336  DT.100789254 

    Selected AceView cDNA sequences (see all 104):

    BM759317 BM818422 CR609151 BE795733 BM794052 BM705176 BM782291 AI201243 
    BM745352 NM_014260 BM834357 BU734446 BE047705 BX353804 BM710321 BC059783 
    BM792413 AI184479 AI658592 BM013631 AV707397 CB124036 AI183913 BI461421 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PFDN6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGGGAG
    PFDN6 Expression
    About this image


    PFDN6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
    PFDN6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PFDN6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446374
        Custom PCR Arrays for PFDN6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PFDN6
    OriGene qSTAR qPCR primer pairs in human, mouse for PFDN6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PFDN6
    QuantiTect SYBR Green Assays in human, mouse, rat PFDN6
    QuantiFast Probe-based Assays in human, mouse, rat PFDN6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFDN6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PFDN6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-Ke21 , 5 H2-K region expressed gene 21, 5 90.48(n)1
    100(a)1
      17 (17.98 cM)5
    149761  NM_010385.21  NP_034515.11 
     339388215 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    77(a)
    76(a)
    1 ↔ many
    1 ↔ many
    GL344099.1(45445-48429)
    GL343733.1(236350-240581)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pfdn61 prefoldin subunit 6 67.23(n)
    67.23(a)
      548662  NM_001015908.2  NP_001015908.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pfdn61 prefoldin subunit 6 68.63(n)
    76.47(a)
      393485  NM_200513.1  NP_956807.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77701 CG7770 53.57(n)
    49.11(a)
      40176  NM_001275150.1  NP_001262079.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pfd-66
    Protein PFD-6 (pfd-6) mRNA, complete cds
    41(a)
    1 ↔ 1
    I(7282960-7283818) WBGene00009004
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKE2(YLR200W)4 Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin less   --   12(549012-549356) 850897  NP_013301.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PFD61 PFD6 50.14(n)
    44.35(a)
      839878  NM_102739.3  NP_174292.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g02463001 Os02g0246300 50.14(n)
    41.74(a)
      4328867  NM_001052960.2  NP_001046425.2 


    ENSEMBL Gene Tree for PFDN6 (if available)
    TreeFam Gene Tree for PFDN6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PFDN6 gene
    1 SIMAP similar gene for PFDN6 using alignment to 3 protein entries:     PFD6_HUMAN (see all proteins):
    HKE2

    Find genes that share paralogs with PFDN6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PFDN6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830634CNV Loss17160897
    nsv830635CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PFDN6
    DNA2.0 Custom Variant and Variant Library Synthesis for PFDN6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605660    OMIM disorders: --


    Find genes that share disorders with PFDN6           About GenesLikeMe

    Genetic Association Database (GAD): PFDN6
    Human Genome Epidemiology (HuGE) Navigator: PFDN6 (2 documents)

    Export disorders for PFDN6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PFDN6 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with PFDN6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)1, 2, 3 Herberg J.A.... Trowsdale J. (J. Mol. Biol. 1998)
    2. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PubMed id 9630229)1, 2, 3 Vainberg I.E.... Cowan N.J. (Cell 1998)
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. (PubMed id 17257322)1, 9 Ostrov D.A....Iczkowski K.A. (Tissue Antigens 2007)
    6. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10471 HGNC: 4926 AceView: HKE2 Ensembl:ENSG00000204220 euGenes: HUgn10471
    ECgene: PFDN6 H-InvDB: PFDN6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PFDN6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PFDN6 gene:
    Search GeneIP for patents involving PFDN6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PFDN6   OriGene RNAi products in human, mouse, rat for PFDN6  
     OriGene qPCR primer pairs and template standards for PFDN6   OriGene Protein Over-expression Lysate for PFDN6  
     OriGene MassSpec for PFDN6   OriGene clones in human, mouse for PFDN6  
     OriGene qSTAR qPCR primer pairs in human, mouse for PFDN6   OriGene Purified Protein for PFDN6  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PFDN6   OriGene Custom Protein Services for PFDN6  

     
     
     Block miRNA regulation of human, mouse, rat PFDN6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PFDN6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PFDN6 Predesigned siRNA for gene silencing in human, mouse, rat PFDN6
     QuantiFast Probe-based Assays in human, mouse, rat PFDN6 QuantiTect SYBR Green Assays in human, mouse, rat PFDN6
     Custom PCR Arrays for PFDN6 Search Chromatin IP Primers for PFDN6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PFDN6  Search GeneGlobe Interaction Network for PFDN6
     Regulatory tfbs in PFDN6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PFDN6 GenScript cDNA clones with any tag delivered in your preferred vector for PFDN6
     GenScript Custom Assay Services for PFDN6 GenScript Custom overexpressing Cell Line Services for PFDN6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PFDN6 (PFD6)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PFDN6 antibodies
     PFDN6 proteins
     PFDN6 lysates
     Antibodies for PFDN6
     See all of Abcam's Antibodies, Kits and Proteins for PFDN6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PFDN6
     Proteins for PFDN6
     Antibodies for PFDN6
     ELISAs for PFDN6
     CLIAs for PFDN6



     Browse ESI BIO Cell Lines and PureStem Progenitors for PFDN6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFDN6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PFDN6
     SwitchGear Promoter luciferase reporter plasmids for PFDN6
     ThermoFisher Antibodies for PFDN6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFDN6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PFDN6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PFDN6
     LSBio Antibodies in human, mouse, rat for PFDN6
     Browse compounds at ApexBio
     Search Addgene for plasmids for PFDN6
      Search eBioscience for proteins for PFDN6
      Search eBioscience for elisas for PFDN6
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for PFDN6 (9 products)
     antibodies-online kits for PFDN6 (20 products)
     antibodies-online peptides for PFDN6
     antibodies-online proteins for PFDN6 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PFDN6 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4