Aliases for PFDN6 Gene
External Ids for PFDN6 Gene
Previous HGNC Symbols for PFDN6 Gene
Previous GeneCards Identifiers for PFDN6 Gene
PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]
GeneCards Summary for PFDN6 Gene
PFDN6 (Prefoldin Subunit 6) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Protein folding. GO annotations related to this gene include unfolded protein binding and chaperone binding.
UniProtKB/Swiss-Prot for PFDN6 Gene
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.