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PFDN5 Gene

protein-coding   GIFtS: 58
GCID: GC12P053689

Prefoldin Subunit 5

(Previous name: prefoldin 5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Prefoldin Subunit 51 2     C-Myc Binding Protein2
MM12 3 5     Myc Modulator-12
PFD52 3     C-Myc-Binding Protein Mm-13
Prefoldin 51     Myc Modulator 13
MM-12     

External Ids:    HGNC: 88691   Entrez Gene: 52042   Ensembl: ENSG000001233497   OMIM: 6048995   UniProtKB: Q994713   
ORGUL members:         

Export aliases for PFDN5 gene to outside databases

Previous GC identifers: GC12M054016 GC12M053811 GC12P053406 GC12P051975 GC12P050730


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PFDN5 Gene:
This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of
prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby
allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta
barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional
activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have
been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for PFDN5 Gene:
PFDN5 (prefoldin subunit 5) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and transcription corepressor activity.

UniProtKB/Swiss-Prot: PFD5_HUMAN, Q99471
Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent
polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative
proteins. Represses the transcriptional activity of MYC

Gene Wiki entry for PFDN5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PFDN5 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPFDN5 promoter sequence
   Search Chromatin IP Primers for PFDN5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PFDN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

PFDN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFDN5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053689:  view genomic region     (about GC identifiers)

Start:
53,689,075 bp from pter      End:
53,693,234 bp from pter
Size:
4,160 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PFD5_HUMAN, Q99471 (See protein sequence)
Recommended Name: Prefoldin subunit 5  
Size: 154 amino acids; 17328 Da
Subunit: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to MYC; interacts with its
N-terminal domain
Sequence caution: Sequence=BAA14006.1; Type=Erroneous initiation;
Secondary accessions: A8K9A8 Q54AA8 Q9C083 Q9C084
Alternative splicing: 3 isoforms:  Q99471-1   Q99471-2   Q99471-3   (Does not repress transcription activity of MYC)

Explore the universe of human proteins at neXtProt for PFDN5: NX_Q99471

Explore proteomics data for PFDN5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys112, Lys153
  • Modification sites at PhosphoSitePlus

  • See PFDN5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002615.2  NP_665904.1  

    ENSEMBL proteins: 
     ENSP00000447942   ENSP00000450068   ENSP00000266964   ENSP00000454489   ENSP00000449388  
     ENSP00000243040   ENSP00000334188   ENSP00000450380   ENSP00000455296  
    Reactome Protein details: Q99471

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR004127 Prefoldin_subunit_alpha
     IPR009053 Prefoldin
     IPR011599 PFD_alpha
     IPR027236 PFDN5

    Graphical View of Domain Structure for InterPro Entry Q99471

    ProtoNet protein and cluster: Q99471

    1 Blocks protein domain: IPB004127 Putative prefoldin chaperone

    UniProtKB/Swiss-Prot: PFD5_HUMAN, Q99471
    Similarity: Belongs to the prefoldin subunit alpha family


    Find genes that share domains with PFDN5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PFD5_HUMAN, Q99471
    Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent
    polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative
    proteins. Represses the transcriptional activity of MYC

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS9792694
    GO:0005515protein binding IPI17728244
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with PFDN5           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pfdn5):
     behavior/neurological  cellular  endocrine/exocrine gland  mortality/aging  nervous system 
     reproductive system  vision/eye 

    Find genes that share phenotypes with PFDN5           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PFDN5

    miRNA
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    miRTarBase miRNAs that target PFDN5:
    hsa-mir-26b-5p (MIRT028919)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PFD5_HUMAN, Q99471: Isoform 1: Nucleus
    PFD5_HUMAN, Q99471: Isoform 2: Cytoplasm
    PFD5_HUMAN, Q99471: Isoform 3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169
    GO:0016272prefoldin complex IEA--

    Find genes that share ontologies with PFDN5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PFDN5 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Protein folding0.91
    Chaperonin-mediated protein folding0.91
    2Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with PFDN5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PFDN5
        Prefoldin mediated transfer of substrate to CCT/TriC


        Pathway & Disease-focused RT2 Profiler PCR Arrays including PFDN5: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PFDN5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PFDN5 (Q994711, 3 ENSP000003341884) via UniProtKB, MINT, STRING, and/or I2D (see all 430)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS9792694
    GO:0006457protein folding TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0045892negative regulation of transcription, DNA-templated IMP18281035
    GO:0051084'de novo' posttranslational protein folding TAS--

    Find genes that share ontologies with PFDN5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for PFDN5 (PFD5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PFDN5 gene (3 alternative transcripts): 
    NM_002624.3  NM_145897.2  NM_145896.2  

    Unigene Cluster for PFDN5:

    Prefoldin subunit 5
    Hs.655327  [show with all ESTs]
    Unigene Representative Sequence: BM562920
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000551018(uc001scl.3 uc001scm.3 uc001scn.3) ENST00000550880
    ENST00000351500 ENST00000550069 ENST00000550846 ENST00000551223 ENST00000552341(uc001sco.3)
    ENST00000547130 ENST00000243040 ENST00000549995 ENST00000334478 ENST00000552742
    ENST00000550513 ENST00000547228 ENST00000549759 ENST00000552548 ENST00000550964
    ENST00000548984
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      QuantiTect SYBR Green Assays in human, mouse, rat PFDN5
      QuantiFast Probe-based Assays in human, mouse, rat PFDN5

    Additional mRNA sequence: 

    AB055803.1 AB055804.1 AB055805.1 AK292623.1 BC003373.1 BC062671.1 BT007195.1 

    20 DOTS entries:

    DT.100689405  DT.70105339  DT.91919614  DT.91869259  DT.100689413  DT.100689411  DT.121216814  DT.95221654 
    DT.87015650  DT.121216836  DT.121216823  DT.121216810  DT.97860177  DT.100689409  DT.100689412  DT.121216804 
    DT.87017488  DT.91770422  DT.95375539  DT.102834234 

    Selected AceView cDNA sequences (see all 968):

    CR614390 CD366897 AA372438 CB111744 BQ671079 BQ355465 AI097465 NM_145897 
    BU788934 AA446453 BE293983 BU752492 CD678514 AI420175 CB138047 BF725762 
    AI193522 W92940 AA430010 AW606964 BQ961297 BM817977 BM549719 AI306455 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PFDN5 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                                  -     -     -     -     -           -                           
    SP2:                                            -     -                 -     -           -                           
    SP3:                                            -     -                                   -                           
    SP4:                                            -     -     -     -     -     -           -                           
    SP5:                                      -     -     -     -                 -           -                           


    ECgene alternative splicing isoforms for PFDN5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PFDN5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGATGA
    PFDN5 Expression
    About this image


    PFDN5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    PFDN5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PFDN5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655327

    UniProtKB/Swiss-Prot: PFD5_HUMAN, Q99471
    Tissue specificity: Highly expressed in pancreas and skeletal muscle and moderately in other tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PFDN5: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PFDN5 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pfdn51 , 5 prefoldin 51, 5 91.13(n)1
    99.35(a)1
      15 (57.48 cM)5
    566121  NM_027044.31  NP_081320.21 
     1023261165 
    chicken
    (Gallus gallus)
    Aves LOC1008593761 prefoldin subunit 5-like 80.3(n)
    89.61(a)
      100859376  XM_003643422.2  XP_003643470.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243302 Xenopus laevis transcribed sequence with moderate similarity more 81.25(n)    CB208561.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa09c112 wufa09c11 76.29(n)   334918  CK363077.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70481 CG7048 51(n)
    38.81(a)
      42647  NM_001170217.2  NP_001163688.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pfd-56
    Protein PFD-5 (pfd-5) mRNA, complete cds
    28(a)
    1 ↔ 1
    III(7198152-7198884) WBGene00020112
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GIM5(YML094W)4
    GIM51
    Subunit of the heterohexameric cochaperone prefoldin more4
    GIM51
    50.95(n)1
    41.46(a)1
      13(82275-82849)4
    8548791, 4  NP_013616.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PFD51 PFD5 48.64(n)
    39.26(a)
      832393  NM_122235.2  NP_197720.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04881001 Os10g0488100 59.32(n)
    52.54(a)
      4348957  NM_001071445.1  NP_001064910.1 


    ENSEMBL Gene Tree for PFDN5 (if available)
    TreeFam Gene Tree for PFDN5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PFDN5 gene

    Find genes that share paralogs with PFDN5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PFDN5
    PGOHUM00000244443


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PFDN5 (see all 106)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386389871,2
    --53688045(+) CACCGC/TGCCCA 2 -- us2k10--------
    rs783411911,2
    F--53688060(+) TGGCAC/GTAGTT 2 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1893230101,2
    --53688094(+) GCCTCC/TTAAGT 2 -- us2k10--------
    rs1488260721,2
    --53688111(+) TAAAGA/GCTACT 2 -- us2k10--------
    rs1171166021,2
    F--53688129(+) GCCCAT/AGTACA 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs797513831,2
    C,F--53688249(+) CACTCT/CCACGT 2 -- us2k13Minor allele frequency- C:0.04CSA WA 122
    rs344483761,2
    C--53688284(+) AAACC-/T/TT  
            
    TTTTT
    2 -- us2k12NA CSA 4
    rs1434203441,2
    --53688459(+) GGTGTC/TGCCGT 2 -- us2k10--------
    rs1820228421,2
    --53688476(+) CAAGCC/TGGTCT 2 -- us2k10--------
    rs599216661,2
    C,F--53688489(+) AACTCC/TTGGGC 2 -- us2k13Minor allele frequency- T:0.12WA NA EA 358

    HapMap Linkage Disequilibrium report for PFDN5 (53689075 - 53693234 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PFDN5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517066CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PFDN5
    DNA2.0 Custom Variant and Variant Library Synthesis for PFDN5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604899    OMIM disorders: --


    Find genes that share disorders with PFDN5           About GenesLikeMe


    Export disorders for PFDN5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PFDN5 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with PFDN5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc. (PubMed id 9792694)1, 2, 3 Mori K.... Ariga H. (J. Biol. Chem. 1998)
    2. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PubMed id 9630229)1, 2, 3 Vainberg I.E.... Cowan N.J. (Cell 1998)
    3. Distinct localizations and repression activities of MM-1 isoforms toward c-Myc. (PubMed id 16173081)1, 2 Hagio Y....Ariga H. (J. Cell. Biochem. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer. (PubMed id 11567024)1, 2 Fujioka Y.... Ariga H. (J. Biol. Chem. 2001)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5204 HGNC: 8869 AceView: PFDN5andC12orf10 Ensembl:ENSG00000123349 euGenes: HUgn5204
    ECgene: PFDN5 H-InvDB: PFDN5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PFDN5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PFDN5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PFDN5 gene:
    Search GeneIP for patents involving PFDN5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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