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Aliases for PFDN4 Gene

Aliases for PFDN4 Gene

  • Prefoldin Subunit 4 2 3 5
  • Prefoldin 4 2 3
  • Protein C-1 3 4
  • PFD4 3 4
  • C1 3

External Ids for PFDN4 Gene

Previous GeneCards Identifiers for PFDN4 Gene

  • GC20P052553
  • GC20P053463
  • GC20P053510
  • GC20P052258
  • GC20P052824
  • GC20P049571

Summaries for PFDN4 Gene

Entrez Gene Summary for PFDN4 Gene

  • This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]

GeneCards Summary for PFDN4 Gene

PFDN4 (Prefoldin Subunit 4) is a Protein Coding gene. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and chaperone binding.

UniProtKB/Swiss-Prot for PFDN4 Gene

  • Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Wiki entry for PFDN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFDN4 Gene

Genomics for PFDN4 Gene

Regulatory Elements for PFDN4 Gene

Enhancers for PFDN4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PFDN4 on UCSC Golden Path with GeneCards custom track

Promoters for PFDN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PFDN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PFDN4 Gene

54,207,847 bp from pter
54,228,052 bp from pter
20,206 bases
Plus strand

Genomic View for PFDN4 Gene

Genes around PFDN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PFDN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PFDN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PFDN4 Gene

Proteins for PFDN4 Gene

  • Protein details for PFDN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prefoldin subunit 4
    Protein Accession:
    Secondary Accessions:
    • Q5TD11
    • Q92779

    Protein attributes for PFDN4 Gene

    134 amino acids
    Molecular mass:
    15314 Da
    Quaternary structure:
    • Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.

neXtProt entry for PFDN4 Gene

Proteomics data for PFDN4 Gene at MOPED

Post-translational modifications for PFDN4 Gene

  • Ubiquitination at Lys 7
  • Modification sites at PhosphoSitePlus

Other Protein References for PFDN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PFDN4 Gene

Domains & Families for PFDN4 Gene

Gene Families for PFDN4 Gene

Protein Domains for PFDN4 Gene

Suggested Antigen Peptide Sequences for PFDN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the prefoldin subunit beta family.
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PFDN4: view

Function for PFDN4 Gene

Molecular function for PFDN4 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Ontology (GO) - Molecular Function for PFDN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with PFDN4: view

Phenotypes for PFDN4 Gene

GenomeRNAi human phenotypes for PFDN4:
genes like me logo Genes that share phenotypes with PFDN4: view

Animal Model Products

miRNA for PFDN4 Gene

miRTarBase miRNAs that target PFDN4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PFDN4 Gene

Localization for PFDN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PFDN4 Gene

Nucleus. Cytoplasm. Mitochondrion.

Subcellular locations from

Jensen Localization Image for PFDN4 Gene COMPARTMENTS Subcellular localization image for PFDN4 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
plasma membrane 2
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PFDN4 Gene

Pathways & Interactions for PFDN4 Gene

genes like me logo Genes that share pathways with PFDN4: view

Gene Ontology (GO) - Biological Process for PFDN4 Gene


No data available for SIGNOR curated interactions for PFDN4 Gene

Drugs & Compounds for PFDN4 Gene

No Compound Related Data Available

Transcripts for PFDN4 Gene

Unigene Clusters for PFDN4 Gene

Prefoldin subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PFDN4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP2: - - - - -
SP3: - -
SP4: -

Relevant External Links for PFDN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PFDN4 Gene

mRNA expression in normal human tissues for PFDN4 Gene

Protein differential expression in normal tissues from HIPED for PFDN4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PFDN4 Gene

SOURCE GeneReport for Unigene cluster for PFDN4 Gene Hs.91161

genes like me logo Genes that share expression patterns with PFDN4: view

Protein tissue co-expression partners for PFDN4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PFDN4 Gene

Orthologs for PFDN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PFDN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PFDN4 35
  • 95.52 (n)
  • 99.25 (a)
PFDN4 36
  • 83 (a)
(Canis familiaris)
Mammalia PFDN4 35
  • 91.98 (n)
  • 91.73 (a)
PFDN4 36
  • 95 (a)
(Mus musculus)
Mammalia Pfdn4 35
  • 84.68 (n)
  • 96.77 (a)
Pfdn4 16
Pfdn4 36
  • 97 (a)
(Pan troglodytes)
Mammalia PFDN4 35
  • 98.97 (n)
  • 100 (a)
PFDN4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Pfdn4 35
  • 83.06 (n)
  • 94.35 (a)
(Monodelphis domestica)
Mammalia PFDN4 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia PFDN4 36
  • 81 (a)
(Gallus gallus)
Aves PFDN4 35
  • 81.99 (n)
  • 91.13 (a)
PFDN4 36
  • 91 (a)
(Anolis carolinensis)
Reptilia PFDN4 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pfdn4 35
  • 73.98 (n)
  • 81.3 (a)
Str.11250 35
(Danio rerio)
Actinopterygii Dr.14011 35
pfdn4 35
  • 70.43 (n)
  • 81.45 (a)
pfdn4 36
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12242 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006946 35
  • 53.44 (n)
  • 49.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10635 35
  • 52.19 (n)
  • 44.26 (a)
CG10635 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea pfd-4 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIM3 36
  • 35 (a)
GIM3 38
Species with no ortholog for PFDN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PFDN4 Gene

Gene Tree for PFDN4 (if available)
Gene Tree for PFDN4 (if available)

Paralogs for PFDN4 Gene Pseudogenes for PFDN4 Gene

genes like me logo Genes that share paralogs with PFDN4: view

No data available for Paralogs for PFDN4 Gene

Variants for PFDN4 Gene

Sequence variations from dbSNP and Humsavar for PFDN4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs24049 -- 54,220,237(-) AAAAA(A/G)AAAAG downstream-variant-500B
rs1961795 -- 54,210,220(+) ACTTA(C/T)AGAGG intron-variant
rs1964861 -- 54,215,166(+) ATTAA(C/G)GTCTT intron-variant
rs1418925 -- 54,209,192(+) CAGGC(A/G)CGGAG intron-variant
rs1418926 -- 54,210,729(+) ACTCC(G/T)AAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PFDN4 Gene

Variant ID Type Subtype PubMed ID
nsv834010 CNV Loss 17160897

Variation tolerance for PFDN4 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PFDN4 Gene

Disorders for PFDN4 Gene

Relevant External Links for PFDN4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PFDN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PFDN4 Gene

Publications for PFDN4 Gene

  1. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PMID: 9630229) Vainberg I.E. … Cowan N.J. (Cell 1998) 2 3 4 67
  2. Comprehensive genome sequence analysis of a breast cancer amplicon. (PMID: 11381030) Collins C. … Gray J.W. (Genome Res. 2001) 3 23
  3. Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines. (PMID: 8744932) Iijima M. … Namba M. (Acta Med. Okayama 1996) 2 3
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3

Products for PFDN4 Gene

Sources for PFDN4 Gene