External Ids for PFDN4 Gene
Previous GeneCards Identifiers for PFDN4 Gene
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
GeneCards Summary for PFDN4 Gene
PFDN4 (Prefoldin Subunit 4) is a Protein Coding gene. Diseases associated with PFDN4 include distal arthrogryposis. Among its related pathways are Transport to the Golgi and subsequent modification and Protein folding. GO annotations related to this gene include unfolded protein binding and chaperone binding.
UniProtKB/Swiss-Prot for PFDN4 Gene
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.