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Aliases for PFDN4 Gene

Aliases for PFDN4 Gene

  • Prefoldin Subunit 4 2 3
  • Prefoldin 4 2 3
  • Protein C-1 3 4
  • PFD4 3 4
  • C1 3

External Ids for PFDN4 Gene

Previous GeneCards Identifiers for PFDN4 Gene

  • GC20P052553
  • GC20P053463
  • GC20P053510
  • GC20P052258
  • GC20P052824
  • GC20P049571

Summaries for PFDN4 Gene

Entrez Gene Summary for PFDN4 Gene

  • This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]

GeneCards Summary for PFDN4 Gene

PFDN4 (Prefoldin Subunit 4) is a Protein Coding gene. Diseases associated with PFDN4 include distal arthrogryposis. Among its related pathways are Transport to the Golgi and subsequent modification and Protein folding. GO annotations related to this gene include unfolded protein binding and chaperone binding.

UniProtKB/Swiss-Prot for PFDN4 Gene

  • Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Wiki entry for PFDN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFDN4 Gene

Genomics for PFDN4 Gene

Regulatory Elements for PFDN4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PFDN4 Gene

Chromosome:
20
Start:
54,207,847 bp from pter
End:
54,228,052 bp from pter
Size:
20,206 bases
Orientation:
Plus strand

Genomic View for PFDN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PFDN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PFDN4 Gene

Proteins for PFDN4 Gene

  • Protein details for PFDN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQP4-PFD4_HUMAN
    Recommended name:
    Prefoldin subunit 4
    Protein Accession:
    Q9NQP4
    Secondary Accessions:
    • Q5TD11
    • Q92779

    Protein attributes for PFDN4 Gene

    Size:
    134 amino acids
    Molecular mass:
    15314 Da
    Quaternary structure:
    • Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.

neXtProt entry for PFDN4 Gene

Proteomics data for PFDN4 Gene at MOPED

Post-translational modifications for PFDN4 Gene

  • Ubiquitination at Lys 7
  • Modification sites at PhosphoSitePlus

Other Protein References for PFDN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PFDN4 Gene

Domains & Families for PFDN4 Gene

Gene Families for PFDN4 Gene

Protein Domains for PFDN4 Gene

Suggested Antigen Peptide Sequences for PFDN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQP4

UniProtKB/Swiss-Prot:

PFD4_HUMAN :
  • Belongs to the prefoldin subunit beta family.
Family:
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PFDN4: view

Function for PFDN4 Gene

Molecular function for PFDN4 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Ontology (GO) - Molecular Function for PFDN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17936702
GO:0051082 unfolded protein binding IEA --
GO:0051087 chaperone binding TAS 9630229
genes like me logo Genes that share ontologies with PFDN4: view

Phenotypes for PFDN4 Gene

GenomeRNAi human phenotypes for PFDN4:
genes like me logo Genes that share phenotypes with PFDN4: view

miRNA for PFDN4 Gene

miRTarBase miRNAs that target PFDN4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PFDN4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PFDN4 Gene

Localization for PFDN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PFDN4 Gene

Nucleus. Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PFDN4 Gene COMPARTMENTS Subcellular localization image for PFDN4 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PFDN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17936702
GO:0005737 cytoplasm IDA 17936702
GO:0005739 mitochondrion IDA 17936702
GO:0005829 cytosol NAS 9630229
GO:0016272 prefoldin complex IEA --
genes like me logo Genes that share ontologies with PFDN4: view

Pathways & Interactions for PFDN4 Gene

genes like me logo Genes that share pathways with PFDN4: view

Gene Ontology (GO) - Biological Process for PFDN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9630229
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
genes like me logo Genes that share ontologies with PFDN4: view

No data available for SIGNOR curated interactions for PFDN4 Gene

Drugs & Compounds for PFDN4 Gene

No Compound Related Data Available

Transcripts for PFDN4 Gene

mRNA/cDNA for PFDN4 Gene

Unigene Clusters for PFDN4 Gene

Prefoldin subunit 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PFDN4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PFDN4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - - - - -
SP3: - -
SP4: -

Relevant External Links for PFDN4 Gene

GeneLoc Exon Structure for
PFDN4
ECgene alternative splicing isoforms for
PFDN4

Expression for PFDN4 Gene

mRNA expression in normal human tissues for PFDN4 Gene

Protein differential expression in normal tissues from HIPED for PFDN4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PFDN4 Gene



SOURCE GeneReport for Unigene cluster for PFDN4 Gene Hs.91161

genes like me logo Genes that share expression patterns with PFDN4: view

Protein tissue co-expression partners for PFDN4 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PFDN4 Gene

Orthologs for PFDN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PFDN4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PFDN4 35
  • 95.52 (n)
  • 99.25 (a)
PFDN4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PFDN4 35
  • 91.98 (n)
  • 91.73 (a)
PFDN4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pfdn4 35
  • 84.68 (n)
  • 96.77 (a)
Pfdn4 16
Pfdn4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PFDN4 35
  • 98.97 (n)
  • 100 (a)
PFDN4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pfdn4 35
  • 83.06 (n)
  • 94.35 (a)
oppossum
(Monodelphis domestica)
Mammalia PFDN4 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PFDN4 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PFDN4 35
  • 81.99 (n)
  • 91.13 (a)
PFDN4 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PFDN4 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pfdn4 35
  • 73.98 (n)
  • 81.3 (a)
Str.11250 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14011 35
pfdn4 35
  • 70.43 (n)
  • 81.45 (a)
pfdn4 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12242 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006946 35
  • 53.44 (n)
  • 49.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10635 35
  • 52.19 (n)
  • 44.26 (a)
CG10635 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pfd-4 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIM3 36
  • 35 (a)
OneToOne
GIM3 38
Species with no ortholog for PFDN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PFDN4 Gene

ENSEMBL:
Gene Tree for PFDN4 (if available)
TreeFam:
Gene Tree for PFDN4 (if available)

Paralogs for PFDN4 Gene

Pseudogenes.org Pseudogenes for PFDN4 Gene

genes like me logo Genes that share paralogs with PFDN4: view

No data available for Paralogs for PFDN4 Gene

Variants for PFDN4 Gene

Sequence variations from dbSNP and Humsavar for PFDN4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs24049 -- 54,220,237(-) AAAAA(A/G)AAAAG downstream-variant-500B
rs1418925 -- 54,209,192(+) CAGGC(A/G)CGGAG intron-variant
rs1418926 -- 54,210,729(+) ACTCC(G/T)AAGCT intron-variant
rs1418927 -- 54,210,754(+) ATCAC(A/G)TTTGT intron-variant
rs1961795 -- 54,210,220(+) ACTTA(C/T)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PFDN4 Gene

Variant ID Type Subtype PubMed ID
nsv834010 CNV Loss 17160897

Variation tolerance for PFDN4 Gene

Residual Variation Intolerance Score: 65.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PFDN4 Gene

HapMap Linkage Disequilibrium report
PFDN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFDN4 Gene

Disorders for PFDN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PFDN4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
distal arthrogryposis
  • arthrogryposis, distal, type 2b
- elite association
Search PFDN4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PFDN4

Genetic Association Database (GAD)
PFDN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PFDN4
genes like me logo Genes that share disorders with PFDN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PFDN4 Gene

Publications for PFDN4 Gene

  1. Translation termination and protein folding pathway genes are not correlated in gastric cancer. (PMID: 19284299) Malta-Vacas J. … Brito M. (Clin. Chem. Lab. Med. 2009) 23 67
  2. Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. (PMID: 17989073) Infante R.E. … Goldstein J.L. (J. Biol. Chem. 2008) 23 67
  3. Myocardial infarction in an adolescent: anomalous origin of the left main coronary artery from the right coronary sinus in association with combined prothrombotic defects. (PMID: 17671046) Koestenberger M. … Beitzke A. (Pediatrics 2007) 23 67
  4. The safety of moderate hypothermic lower body circulatory arrest with selective cerebral perfusion: a propensity score analysis. (PMID: 17258589) Kamiya H. … Karck M. (J. Thorac. Cardiovasc. Surg. 2007) 23 67
  5. Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6. (PMID: 12414651) Kurata M. … Ohno H. (Cancer Res. 2002) 23 67

Products for PFDN4 Gene

Sources for PFDN4 Gene

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