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Aliases for PFDN2 Gene

Aliases for PFDN2 Gene

  • Prefoldin Subunit 2 2 3 5
  • Prefoldin 2 2 3
  • PFD2 3 4

External Ids for PFDN2 Gene

Previous GeneCards Identifiers for PFDN2 Gene

  • GC01M158781
  • GC01M156802
  • GC01M157848
  • GC01M158287
  • GC01M157883
  • GC01M159336
  • GC01M161070
  • GC01M132427

Summaries for PFDN2 Gene

Entrez Gene Summary for PFDN2 Gene

  • This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]

GeneCards Summary for PFDN2 Gene

PFDN2 (Prefoldin Subunit 2) is a Protein Coding gene. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and protein binding involved in protein folding.

UniProtKB/Swiss-Prot for PFDN2 Gene

  • Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Wiki entry for PFDN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PFDN2 Gene

Genomics for PFDN2 Gene

Regulatory Elements for PFDN2 Gene


Promoters for PFDN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014637 211 1801 HDGF CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for PFDN2 Gene

Chromosome:
1
Start:
161,100,556 bp from pter
End:
161,118,111 bp from pter
Size:
17,556 bases
Orientation:
Minus strand

Genomic View for PFDN2 Gene

Genes around PFDN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PFDN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PFDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PFDN2 Gene

Proteins for PFDN2 Gene

  • Protein details for PFDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHV9-PFD2_HUMAN
    Recommended name:
    Prefoldin subunit 2
    Protein Accession:
    Q9UHV9
    Secondary Accessions:
    • Q9P0P7
    • Q9UN05

    Protein attributes for PFDN2 Gene

    Size:
    154 amino acids
    Molecular mass:
    16648 Da
    Quaternary structure:
    • Binds to c-Myc; interacts with its N-terminal domain (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.
    SequenceCaution:
    • Sequence=AAF36151.1; Type=Frameshift; Positions=8, 23, 28, 34; Evidence={ECO:0000305};

neXtProt entry for PFDN2 Gene

Post-translational modifications for PFDN2 Gene

  • Ubiquitination at posLast=1818, posLast=9999, posLast=113113, and Lys136
  • Modification sites at PhosphoSitePlus

Other Protein References for PFDN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PFDN2 Gene

Domains & Families for PFDN2 Gene

Gene Families for PFDN2 Gene

Protein Domains for PFDN2 Gene

Suggested Antigen Peptide Sequences for PFDN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHV9

UniProtKB/Swiss-Prot:

PFD2_HUMAN :
  • Belongs to the prefoldin subunit beta family.
Family:
  • Belongs to the prefoldin subunit beta family.
genes like me logo Genes that share domains with PFDN2: view

Function for PFDN2 Gene

Molecular function for PFDN2 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Ontology (GO) - Molecular Function for PFDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15923622
GO:0044183 protein binding involved in protein folding IPI 16876117
GO:0051082 unfolded protein binding NAS 9630229
genes like me logo Genes that share ontologies with PFDN2: view
genes like me logo Genes that share phenotypes with PFDN2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PFDN2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PFDN2 Gene

Localization for PFDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PFDN2 Gene

Nucleus. Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PFDN2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for PFDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16876117
GO:0005737 cytoplasm IEA,IDA 16876117
GO:0005739 mitochondrion IDA,IEA 17936702
GO:0005829 cytosol IDA --
GO:0016272 prefoldin complex NAS 9630229
genes like me logo Genes that share ontologies with PFDN2: view

Pathways & Interactions for PFDN2 Gene

genes like me logo Genes that share pathways with PFDN2: view

Gene Ontology (GO) - Biological Process for PFDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 9630229
GO:0051495 positive regulation of cytoskeleton organization IDA 16876117
genes like me logo Genes that share ontologies with PFDN2: view

No data available for SIGNOR curated interactions for PFDN2 Gene

Transcripts for PFDN2 Gene

mRNA/cDNA for PFDN2 Gene

Unigene Clusters for PFDN2 Gene

Prefoldin subunit 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PFDN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PFDN2 Gene

No ASD Table

Relevant External Links for PFDN2 Gene

GeneLoc Exon Structure for
PFDN2
ECgene alternative splicing isoforms for
PFDN2

Expression for PFDN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PFDN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PFDN2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PFDN2 Gene



Protein tissue co-expression partners for PFDN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PFDN2 Gene:

PFDN2

SOURCE GeneReport for Unigene cluster for PFDN2 Gene:

Hs.492516

Evidence on tissue expression from TISSUES for PFDN2 Gene

  • Liver(4.4)
  • Adrenal gland(4.3)
  • Skin(4.2)
  • Blood(4.1)
  • Nervous system(2.8)
  • Heart(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PFDN2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PFDN2 Gene

Orthologs for PFDN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PFDN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PFDN2 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia PFDN2 34 35
  • 94.81 (n)
-- 35
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PFDN2 34 35
  • 91.77 (n)
mouse
(Mus musculus)
Mammalia Pfdn2 34 16 35
  • 91.56 (n)
oppossum
(Monodelphis domestica)
Mammalia PFDN2 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pfdn2 34
  • 89.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PFDN2 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves PFDN2 34 35
  • 70.6 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia pfdn2 34
  • 72.39 (n)
Str.17618 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4972 34
zebrafish
(Danio rerio)
Actinopterygii pfdn2 34 35
  • 65.36 (n)
wufb79a01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9948 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006070 34
  • 55.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(3)01239 34 35
  • 53.09 (n)
worm
(Caenorhabditis elegans)
Secernentea pfd-2 35
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIM4 37 35
  • 37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PDF2 34
  • 50 (n)
rice
(Oryza sativa)
Liliopsida Os11g0568500 34
  • 49.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4232 35
  • 50 (a)
OneToOne
Species where no ortholog for PFDN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PFDN2 Gene

ENSEMBL:
Gene Tree for PFDN2 (if available)
TreeFam:
Gene Tree for PFDN2 (if available)

Paralogs for PFDN2 Gene

No data available for Paralogs for PFDN2 Gene

Variants for PFDN2 Gene

Sequence variations from dbSNP and Humsavar for PFDN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000050394 -- 161,119,877(+) GGGCA(A/G)GGGCC upstream-variant-2KB, reference, synonymous-codon
rs1000111474 -- 161,109,513(+) TCTAT(G/T)TCTTT intron-variant
rs1000347712 -- 161,102,801(+) AAAAA(C/T)AGAAA intron-variant
rs1000448521 -- 161,108,164(+) AAAAA(A/C)AAACA intron-variant
rs1000820564 -- 161,104,893(+) CATCT(A/G)TCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PFDN2 Gene

Variant ID Type Subtype PubMed ID
nsv1161729 CNV duplication 26073780

Variation tolerance for PFDN2 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PFDN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PFDN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PFDN2 Gene

Disorders for PFDN2 Gene

Relevant External Links for PFDN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PFDN2

No disorders were found for PFDN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PFDN2 Gene

Publications for PFDN2 Gene

  1. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. (PMID: 17936702) Djouder N. … Krek W. (Mol. Cell 2007) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  5. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). (PMID: 10051400) Eddleston J. … Stanier P. (Genomics 1999) 2 3 64

Products for PFDN2 Gene

Sources for PFDN2 Gene

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