PFDN1 Gene
protein-coding GIFtS: 56
GCID: GC05M139604
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prefoldin subunit 1(Previous name: prefoldin 1 )
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Aliases for PFDN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Prefoldin Subunit 11 2 | | PFD11 2 3 | | Prefoldin 11 2 | | PDF2 |
Export aliases for PFDN1 gene to outside databasesPrevious GC identifers: GC05M139447 GC05M140207 GC05M139607 GC05M139653 GC05M134769 |
Summaries for PFDN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for PFDN1: This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits ofprefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowingthem to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrelassembly with six protruding coiled-coils. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: PFD1_HUMAN, O60925Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascentpolypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnativeproteins Gene Wiki entry for PFDN1
|
Genomic Views for PFDN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PFDN1 gene promoter: ATF-2 LCR-F1 Evi-1 CREB POU2F1 FOXO4 FOXJ2 (long isoform) POU2F1a deltaCREB FOXJ2 Other transcription factors
Search SABiosciences Chromatin IP Primers for PFDN1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFDN1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31PFDN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M139604: view genomic region
(about GC identifiers)
Start:
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139,624,624 bp from pter |
End:
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139,682,706 bp from pter |
Size:
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58,083 bases |
Orientation:
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minus strand |
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Proteins for PFDN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: PFD1_HUMAN, O60925 (See
protein sequence)Recommended Name: Prefoldin subunit 1 Size: 122 amino acids; 14210 Da
Subunit: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits
Secondary accessions: B2RD02 Q53F95 Q96EX6Explore the universe of human proteins at neXtProt for PFDN1: NX_O60925
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60925 PFDN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002613.2 ENSEMBL proteins: ENSP00000261813 ENSP00000426383 ENSP00000428707 Reactome Protein details: O60925 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016272 | prefoldin complex |
IEA | -- |
PFDN1 for ontologies About GeneDecksing
PFDN1 Antibody Products: Assay Products for PFDN1: |
Protein
Domains / Families for PFDN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PFDN1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60925ProtoNet protein and cluster: O60925 1 Blocks protein family: IPB002777 Prefoldin-related KE2 protein
UniProtKB/Swiss-Prot: PFD1_HUMAN, O60925Similarity: Belongs to the prefoldin subunit beta family |
Function for PFDN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: PFD1_HUMAN, O60925Function: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascentpolypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnativeproteins Genatlas biochemistry entry for PFDN1:prefoldin subunit 1,keratin homologous
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PFDN1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PFDN1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFDN1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
TAS | 8744932 | | GO:0051082 | unfolded protein binding |
IEA | -- |
PFDN1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for PFDN1: Animal Models: 8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pfdn1):
PFDN1 for phenotypes About GeneDecksing
|
Pathways & Interactions for PFDN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chaperonin-mediated protein folding | | | 2 | Formation of tubulin folding intermediates by CCT/TriC | | | 3 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
5
Reactome Pathways for PFDN1
PFDN1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PFDN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/90 Interacting proteins for PFDN1 (O609252, 3 ENSP000002618134) via UniProtKB, MINT, STRING, and/or I2D (see all 90)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
PFDN1 for ontologies About GeneDecksing
|
Drugs & Compounds for PFDN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for PFDN1 Search CenterWatch for drugs/clinical trials and news about PFDN1 / PFD1 
|
Transcripts for PFDN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for PFDN1 gene: NM_002622.4 Unigene Cluster for PFDN1: Prefoldin subunit 1 Hs.483564 [show with all ESTs]Unigene Representative Sequence: AK0935587 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261813(uc003lff.1) ENST00000514611 ENST00000510217 ENST00000512707 ENST00000524074 ENST00000512925 ENST00000507185
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PFDN1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PFDN1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PFDN1 (NM_002622) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PFDN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFDN1  |
Additional cDNA sequence: AK093558.1 AK223394.1 AK315353.1 BC003620.1 BC006202.1 BC011869.2 Y17392.1 20 DOTS entries: DT.101974730 DT.100880577 DT.319565 DT.100880562 DT.92470190 DT.120860634 DT.120860658 DT.100880575 DT.95082069 DT.120867829 DT.100880580 DT.95334063 DT.100880581 DT.40129481 DT.92470195 DT.100880579 DT.120860629 DT.92470179 DT.95112501 DT.92004836 24/538 AceView cDNA sequences (see all 538): BM453017 CD369109 BQ440995 CR597655 BM759781 BM968723 BQ670938 AA310202 BQ045317 AW160381 AI262235 BP430122 BM768510 R17413 BQ646780 AW162003 AI016676 CR603344 BE393751 BU161515 BQ018957 AI021998 AI246208 BM856055 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for PFDN1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for PFDN1
|
Expression for PFDN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PFDN1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CAGTAGACAG
About this image See PFDN1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PFDN1
SOURCE GeneReport for Unigene cluster: Hs.483564 SABiosciences Expression via Pathway-Focused PCR Array including PFDN1:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PFDN1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PFDN1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PFDN1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PFDN1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFDN1 |
Orthologs for PFDN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PFDN1 gene from 9/22 species (see all 22) About this table
ENSEMBL Gene Tree for PFDN1 (if available) TreeFam Gene Tree for PFDN1 (if available)  |
Paralogs for PFDN1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for PFDN1 gene
PFDN1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PFDN1 PGOHUM00000237941 PGOHUM00000245856
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Genomic Variants for PFDN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for PFDN1 (139624624 - 139682706 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for PFDN1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PFDN1 |
|
Disorders
/ Diseases for PFDN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PFDN1 for disorders About GeneDecksing
OMIM gene information: 604897
OMIM disorders: --
6 diseases for PFDN1: About MalaCardslimb-girdle muscular dystrophy muscular dystrophy acute myeloid leukemia myeloid leukemia hermaphroditism leukemia Export disorders for PFDN1 gene to outside databases
|
Publications for PFDN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PFDN1 gene, integrated from 9 sources (see all 28): (articles sorted by number of sources associating them with PFDN1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. (PubMed id 9630229)1, 2, 3 Vainberg I.E....Cowan N.J. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. (PubMed id 11521196)1, 9 Munnia A.... Meese E. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for PFDN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PFDN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PFDN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PFDN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for PFDN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PFDN1 gene: Search GeneIP for patents involving PFDN1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for PFDN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PFDN1 |
|  |  |  | | | ThermoFisher Antibodies for PFDN1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PFDN1 |
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