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PF4V1 Gene

protein-coding   GIFtS: 53
GCID: GC04P074718

Platelet Factor 4 Variant 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Platelet Factor 4 Variant 11 2     PF4-ALT2
CXCL4L12 3     PF4A2
CXCL4V12 3     C-X-C Motif Chemokine 42
PF4alt2 3     Platelet Factor 4 Variant2
PF4var12 3     Platelet Factor 4, Variant 1 (PF4-Like)2
SCYB4V12 3     C-X-C Motif Chemokine 4 Variant3

External Ids:    HGNC: 88621   Entrez Gene: 51972   Ensembl: ENSG000001092727   OMIM: 1734615   UniProtKB: P107203   

Export aliases for PF4V1 gene to outside databases

Previous GC identifers: GC04P074708 GC04P074958 GC04P075119 GC04P075185 GC04P075084 GC04P070530


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PF4V1 Gene:
PF4V1 (platelet factor 4 variant 1) is a protein-coding gene. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720
Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PF4V1 gene promoter:
         STAT1   AML1a   STAT4   ATF-2   STAT1beta   MyoD   STAT1alpha   Evi-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPF4V1 promoter sequence
   Search Chromatin IP Primers for PF4V1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PF4V1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q21

PF4V1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PF4V1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074718:  view genomic region     (about GC identifiers)

Start:
74,718,906 bp from pter      End:
74,720,198 bp from pter
Size:
1,293 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720 (See protein sequence)
Recommended Name: Platelet factor 4 variant precursor  
Size: 104 amino acids; 11553 Da
Subunit: Homotetramer
Mass spectrometry: Mass=8250.9; Method=Electrospray; Range=31-104; Note=Platelet factor 4 variant;
Source=PubMed:15459074;
Mass spectrometry: Mass=7877.7; Method=Electrospray; Range=34-104; Note=Platelet factor 4 variant(4-74);
Source=PubMed:15459074;
Mass spectrometry: Mass=7805.8; Method=Electrospray; Range=35-104; Note=Platelet factor 4 variant(5-74);
Source=PubMed:15459074;
Mass spectrometry: Mass=7678.6; Method=Electrospray; Range=36-104; Note=Platelet factor 4 variant(6-74);
Source=PubMed:15459074;
Miscellaneous: Binding to heparin is much weaker than in the close homolog PF4/CXCL4
1 PDB 3D structure from and Proteopedia for PF4V1:
4HSV (3D)    
Secondary accessions: A1L4S0

Explore the universe of human proteins at neXtProt for PF4V1: NX_P10720

Explore proteomics data for PF4V1 at MOPED

Post-translational modifications: 

  • The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most
    abundant form is Platelet factor 4 variant(5-74)1
  • Modification sites at neXtProt

  • See PF4V1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002611.1  
    ENSEMBL proteins: 
     ENSP00000226524  
    Reactome Protein details: P10720

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    Cloud-Clone Corp. Proteins for PF4V1

     
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    antibodies-online proteins for PF4V1 (4 products) 

     
    antibodies-online peptides for PF4V1

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    antibodies-online antibodies for PF4V1 (15 products) 

    PF4V1 Assay Products:

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    antibodies-online kits for PF4V1 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027222 PF4
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P10720

    ProtoNet protein and cluster: P10720

    UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Find genes that share domains with PF4V1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PF4V_HUMAN, P10720
    Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro)

         Genatlas biochemistry entry for PF4V1:
    platelet factor 4,variant 1 (see IMC2@)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with PF4V1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PF4V1:
     Increased S DNA content  Increased cell number in G1, a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PF4V1

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    SwitchGear 3'UTR luciferase reporter plasmidPF4V1 3' UTR sequence
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    Sino Biological Human cDNA Clone for PF4V1
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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4V1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PF4V_HUMAN, P10720: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with PF4V1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PF4V1 About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with PF4V1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PF4V1 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation


    2 Reactome Pathways for PF4V1
        Cell surface interactions at the vascular wall
    Common Pathway


    2 Kegg Pathways  (Kegg details for PF4V1):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PF4V1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PF4V1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for PF4V1 (P107203 ENSP000002265244) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    CCR3ENSP000003500034STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0030168platelet activation ----
    GO:0030595leukocyte chemotaxis ----

    Find genes that share ontologies with PF4V1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PF4V1 (PF4V)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PF4V1 gene: 
    NM_002620.2  

    Unigene Cluster for PF4V1:

    Platelet factor 4 variant 1
    Hs.72933
    Unigene Representative Sequence: NM_002620
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000226524(uc003hhg.1)
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      QuantiTect SYBR Green Assays in human, mouse, rat PF4V1
      QuantiFast Probe-based Assays in human, mouse, rat PF4V1

    Additional mRNA sequence: 

    BC130653.1 BC130657.1 

    1 DOTS entry:

    DT.403173 

    2 AceView cDNA sequences:

    NM_002620 C02136 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PF4V1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTCCGCAG
    PF4V1 Expression
    About this image


    PF4V1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    PF4V1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PF4V1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72933
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PF4V1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PF4V1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    32(a)
    1 → many
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    1 → many
    6(60123888-60134622)
            Species with no ortholog for PF4V1

    ENSEMBL Gene Tree for PF4V1 (if available)
    TreeFam Gene Tree for PF4V1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PF4V1 gene
    PPBP2  PF42  CXCL12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
    9 SIMAP similar genes for PF4V1 using alignment to 1 protein entry:     PF4V_HUMAN:
    PF4    CXCL10    CXCL1    CXCL2    CXCL3    IL8
    PPBP    CXCL5    CXCL6

    Find genes that share paralogs with PF4V1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PF4V1 (see all 102)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31175961,2
    C,H--74595352(+) ttatcA/Catttt 1 -- us2k112Minor allele frequency- C:0.02NA WA CSA 258
    rs794935981,2
    C,F--74595429(+) ACCAGC/TATTAC 1 -- us2k12Minor allele frequency- T:0.06NA EA 240
    rs1864328301,2
    --74595538(+) GATCAA/TCATCA 1 -- us2k10--------
    rs1920033841,2
    C--74595548(+) ACTTAC/TACAGT 1 -- us2k10--------
    rs1443544291,2
    --74595549(+) CTTATA/CCAGTC 1 -- us2k10--------
    rs766013701,2
    F--74595553(+) TACAGT/CCTATT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1816126371,2
    --74595584(+) GTGGTA/GGGTGA 1 -- us2k10--------
    rs1180550691,2
    F--74595659(+) TGGACA/GAATAA 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1868565161,2
    --74595724(+) TAATTG/TCTCCA 1 -- us2k10--------
    rs1473725591,2
    --74595768(+) TCATCA/GTCATT 1 -- us2k10--------
    rs1912944231,2
    --74595854(+) TATGAA/TATCTA 1 -- us2k10--------
    rs37754871,2
    C,F,H--74595856(+) TGATAT/CCTAAT 1 -- us2k18Minor allele frequency- C:0.21EA NS NA 1554
    rs1400999701,2
    C--74595926(+) CACAT-/ACACACA 1 -- us2k10--------
    rs790165701,2
    --74595936(+) ACACAC/TATATA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1485683111,2
    --74595958(+) ACAATA/GTATGT 1 -- us2k10--------
    rs286604621,2
    C--74595967(+) GTGTGT/CGTATG 1 -- us2k13Minor allele frequency- C:0.10WA NA 240
    rs31116991,2
    C,H--74595995(+) AAATAG/CGAAGA 1 -- us2k114Minor allele frequency- C:0.00NS EA WA NA CSA 554
    rs1429044791,2
    --74596035(+) GAACAC/TAATTA 1 -- us2k10--------
    rs1827739451,2
    --74596081(+) GATATG/TTAAGC 1 -- us2k10--------
    rs1867816451,2
    --74596142(+) GGAGAA/GTAGGA 1 -- us2k10--------
    rs1511215481,2
    --74596298(+) CCCTGA/TTCAAG 1 -- us2k10--------
    rs8729141,2
    C,F,O,A,H--74596372(+) TGTGGA/GATTCT 1 -- us2k129Minor allele frequency- G:0.47NA EA MN NS WA 4352
    rs764359421,2
    F--74596436(+) GCCCTG/AAATCC 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1410743531,2
    --74596481(+) TGCAGA/CCCATC 1 -- us2k10--------
    rs1900068441,2
    --74596584(+) CAGGAC/TTGAAA 1 -- us2k10--------
    rs37560721,2
    C,F,H--74596608(+) TCCAGG/AAGCTA 1 -- us2k18Minor allele frequency- A:0.16NS EA NA WA 732
    rs21456091,2
    F,H--74596660(+) TTTTTC/ATAAGA 1 -- us2k14Minor allele frequency- A:0.00NS EA 416
    rs1823320841,2
    --74596713(+) TTGTTA/GGTGGA 1 -- us2k10--------
    rs1468002171,2
    --74596816(+) AGTATC/TAGAAA 1 -- us2k10--------
    rs1145725701,2
    F--74597008(+) CAGAAA/CATATT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1876842081,2
    --74597041(+) GTTTCC/TAACTC 1 -- us2k10--------
    rs1931188811,2
    --74597043(+) TTCTAA/GCTCCA 1 -- us2k10--------
    rs9417571,2
    C,F,A,H--74597116(+) GGCAGC/GTGCCC 1 -- us2k111Minor allele frequency- G:0.48MN EA NS NA WA 848
    rs9417581,2
    C,F,A,H--74597212(+) TCCACC/ACCAGG 1 -- us2k1 tfbs326Minor allele frequency- A:0.44EA NA MN NS WA 2852

    HapMap Linkage Disequilibrium report for PF4V1 (74718906 - 74720198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PF4V1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4389CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PF4V1
    DNA2.0 Custom Variant and Variant Library Synthesis for PF4V1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173461    OMIM disorders: --


    Find genes that share disorders with PF4V1           About GenesLikeMe

    Genetic Association Database (GAD): PF4V1
    Human Genome Epidemiology (HuGE) Navigator: PF4V1 (2 documents)

    Export disorders for PF4V1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PF4V1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with PF4V1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of PF4var1, a human gene variant of platelet factor 4. (PubMed id 2725510)1, 2, 3 Green C.J.... Johnson P.H. (Mol. Cell. Biol. 1989)
    2. Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1. (PubMed id 23536183)1, 2 Kuo J.H.... Sue S.C. (J. Biol. Chem. 2013)
    3. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)1, 4 Hillian A.D....Drumm M.L. (Genes Immun. 2008)
    4. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. (PubMed id 15459074)1, 2 Struyf S.... Strieter R.M. (Circ. Res. 2004)
    5. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)1, 2 Eisman R.... Poncz M. (Blood 1990)
    6. CXCL4L1-fibstatin cooperation inhibits tumor angiogenesis, lymphangiogenesis and metastasis. (PubMed id 23747987)1 Prats A.C....Garmy-Susini B. (Microvasc. Res. 2013)
    7. PF-4var/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function. (PubMed id 22384011)1 De Sutter J....Van Damme J. (PLoS ONE 2012)
    8. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    9. CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. (PubMed id 20961394)1 Sarabi A....Von Hundelshausen P. (J. Thromb. Haemost. 2011)
    10. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. (PubMed id 20980681)1 Struyf S....Van Damme J. (Blood 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5197 HGNC: 8862 AceView: PF4V1 Ensembl:ENSG00000109272 euGenes: HUgn5197
    ECgene: PF4V1 Kegg: 5197 H-InvDB: PF4V1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PF4V1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PF4V1 gene:
    Search GeneIP for patents involving PF4V1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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