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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PF4V1 Gene

protein-coding   GIFtS: 54
GCID: GC04P074718

Platelet Factor 4 Variant 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Platelet Factor 4 Variant 11 2     PF4-ALT2
CXCL4L12 3     PF4A2
CXCL4V12 3     C-X-C Motif Chemokine 42
PF4alt2 3     Platelet Factor 4 Variant2
PF4var12 3     Platelet Factor 4, Variant 1 (PF4-Like)2
SCYB4V12 3     C-X-C Motif Chemokine 4 Variant3

External Ids:    HGNC: 88621   Entrez Gene: 51972   Ensembl: ENSG000001092727   OMIM: 1734615   UniProtKB: P107203   

Export aliases for PF4V1 gene to outside databases

Previous GC identifers: GC04P074708 GC04P074958 GC04P075119 GC04P075185 GC04P075084 GC04P070530


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PF4V1 Gene: 
PF4V1 (platelet factor 4 variant 1) is a protein-coding gene. Diseases associated with PF4V1 include cystic fibrosis, and hepatitis b, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720
Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PF4V1 gene promoter:
         STAT1   AML1a   STAT4   ATF-2   STAT1beta   MyoD   STAT1alpha   Evi-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPF4V1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PF4V1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PF4V1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q21

PF4V1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PF4V1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074718:  view genomic region     (about GC identifiers)

Start:
74,718,906 bp from pter      End:
74,720,198 bp from pter
Size:
1,293 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720 (See protein sequence)
Recommended Name: Platelet factor 4 variant precursor  
Size: 104 amino acids; 11553 Da
Subunit: Homotetramer
Subcellular location: Secreted
Mass spectrometry: Mass=8250.9; Method=Electrospray; Range=31-104; Note=Platelet factor 4 variant;
Source=PubMed:15459074;
Mass spectrometry: Mass=7877.7; Method=Electrospray; Range=34-104; Note=Platelet factor 4 variant(4-74);
Source=PubMed:15459074;
Mass spectrometry: Mass=7805.8; Method=Electrospray; Range=35-104; Note=Platelet factor 4 variant(5-74);
Source=PubMed:15459074;
Mass spectrometry: Mass=7678.6; Method=Electrospray; Range=36-104; Note=Platelet factor 4 variant(6-74);
Source=PubMed:15459074;
Miscellaneous: Binding to heparin is much weaker than in the close homolog PF4/CXCL4
1 PDB 3D structure from and Proteopedia for PF4V1:
4HSV (3D)    
Secondary accessions: A1L4S0

Explore the universe of human proteins at neXtProt for PF4V1: NX_P10720

Explore proteomics data for PF4V1 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most
    abundant form is Platelet factor 4 variant(5-74)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10720

  • PF4V1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PF4V1 Protein Expression
    REFSEQ proteins: NP_002611.1  
    ENSEMBL proteins: 
     ENSP00000226524  

    Human Recombinant Protein Products for PF4V1: 
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    Novus Biologicals PF4V1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PF4V1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    PF4V1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for PF4V1 
    Cloud-Clone Corp. CLIAs for PF4V1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR027222 PF4
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P10720

    ProtoNet protein and cluster: P10720

    UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    PF4V1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PF4V_HUMAN, P10720
    Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro)

         Genatlas biochemistry entry for PF4V1:
    platelet factor 4,variant 1 (see IMC2@)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
    GO:0008201heparin binding IEA--
         
    PF4V1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PF4V1:
     Increased S DNA content  Increased cell number in G1, a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PF4V1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PF4V1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PF4V1 

    miRNA
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    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4V1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PF4V1 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PF4V1 (see first 5)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation
    Rho Family GTPases
    Akt Signaling
    PAK Pathway
    MIF Regulation of Innate Immune Cells
    Chemokine Signaling
    STAT3 Pathway
    ERK Signaling
    all-trans-Retinoic Acid Signaling in Brain
    PEDF Induced Signaling
    p38 Signaling
    RAR-Gamma-RXR-Alpha Degradation
    IL-6 Pathway



    2         Kegg Pathways  (Kegg details for PF4V1):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    PF4V1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PF4V1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for PF4V1 (P107203 ENSP000002265244) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    CCR3ENSP000003500034STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0030168platelet activation IEA--
    GO:0030595leukocyte chemotaxis IEA--

    PF4V1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PF4V1 (PF4V)

    Search CenterWatch for drugs/clinical trials and news about PF4V1 / PF4V

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PF4V1 gene: 
    NM_002620.2  

    Unigene Cluster for PF4V1:

    Platelet factor 4 variant 1
    Hs.72933
    Unigene Representative Sequence: NM_002620
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000226524(uc003hhg.1)
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PF4V1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PF4V1
    Sirion Biotech Customized lentivirus for stable overexpression of PF4V1 
                         Customized lentivirus expression plasmids for stable overexpression of PF4V1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PF4V1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PF4V1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PF4V1

    Additional mRNA sequence: 

    BC130653.1 BC130657.1 

    1 DOTS entry:

    DT.403173 

    2 AceView cDNA sequences:

    C02136 NM_002620 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PF4V1 expression in normal human tissues (normalized intensities)      PF4V1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTCCGCAG
    PF4V1 Expression
    About this image


    PF4V1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Mesenchymal Stem Cells (Extraembryonic Tissues)
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Brain (Nervous System)
             Cerebral Cortex

    See PF4V1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PF4V1

    SOURCE GeneReport for Unigene cluster: Hs.72933
        SABiosciences Expression via Pathway-Focused PCR Arrays including PF4V1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4V1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PF4V1 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    28(a)
    possible ortholog
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    33(a)
    possible ortholog
    6(60123888-60134622)
            Species with no ortholog for PF4V1

    ENSEMBL Gene Tree for PF4V1 (if available)
    TreeFam Gene Tree for PF4V1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PF4V1 gene
    PPBP2  PF42  CXCL12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
    9 SIMAP similar genes for PF4V1 using alignment to 1 protein entry:     PF4V_HUMAN:
    PF4    CXCL10    CXCL1    CXCL2    CXCL3    IL8
    PPBP    CXCL5    CXCL6

    PF4V1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/102 SNPs in PF4V1 are shown (see all 102)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31175961,2
    C,H--74595352(+) ttatcA/Catttt 1 -- us2k112Minor allele frequency- C:0.02NA WA CSA 258
    rs794935981,2
    C,F--74595429(+) ACCAGC/TATTAC 1 -- us2k12Minor allele frequency- T:0.06NA EA 240
    rs1864328301,2
    --74595538(+) GATCAA/TCATCA 1 -- us2k10--------
    rs1920033841,2
    C--74595548(+) ACTTAC/TACAGT 1 -- us2k10--------
    rs1443544291,2
    --74595549(+) CTTATA/CCAGTC 1 -- us2k10--------
    rs766013701,2
    F--74595553(+) TACAGT/CCTATT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1816126371,2
    --74595584(+) GTGGTA/GGGTGA 1 -- us2k10--------
    rs1180550691,2
    F--74595659(+) TGGACA/GAATAA 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1868565161,2
    --74595724(+) TAATTG/TCTCCA 1 -- us2k10--------
    rs1473725591,2
    --74595768(+) TCATCA/GTCATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PF4V1 (74718906 - 74720198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PF4V1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4389CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PF4V1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 173461    OMIM disorders: --

    4 diseases for PF4V1:    About MalaCards
    cystic fibrosis    hepatitis b    endotheliitis    hepatitis


    PF4V1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PF4V1
    Human Genome Epidemiology (HuGE) Navigator: PF4V1 (2 documents)

    Export disorders for PF4V1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PF4V1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with PF4V1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of PF4var1, a human gene variant of platelet factor 4. (PubMed id 2725510)1, 2, 3 Green C.J.... Johnson P.H. (1989)
    2. Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1. (PubMed id 23536183)1, 2 Kuo J.H.... Sue S.C. (2013)
    3. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)1, 4 Hillian A.D....Drumm M.L. (2008)
    4. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. (PubMed id 15459074)1, 2 Struyf S.... Strieter R.M. (2004)
    5. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)1, 2 Eisman R.... Poncz M. (1990)
    6. PF-4var/CXCL4L1 predicts outcome in stable coronary ar tery disease patients with preserved left ventricular function. (PubMed id 22384011)1 De Sutter J....Van Damme J. (2012)
    7. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    8. CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. (PubMed id 20961394)1 Sarabi A....Von Hundelshausen P. (2011)
    9. Angiostatic and chemotactic activities of the CXC che mokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. (PubMed id 20980681)1 Struyf S....Van Damme J. (2011)
    10. The role of the CXC chemokines platelet factor-4 (CXC L4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and ca ncer. (PubMed id 21111666)1 Vandercappellen J....Struyf S. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5197 HGNC: 8862 AceView: PF4V1 Ensembl:ENSG00000109272 euGenes: HUgn5197
    ECgene: PF4V1 Kegg: 5197 H-InvDB: PF4V1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PF4V1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PF4V1 gene:
    Search GeneIP for patents involving PF4V1

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