Aliases for PF4V1 Gene
External Ids for PF4V1 Gene
Previous GeneCards Identifiers for PF4V1 Gene
The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]
GeneCards Summary for PF4V1 Gene
PF4V1 (Platelet Factor 4 Variant 1) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is PF4.
UniProtKB/Swiss-Prot for PF4V1 Gene
Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).