PF4V1 Gene
protein-coding GIFtS: 51
GCID: GC04P074718
|
|
platelet factor 4 variant 1
| |
Aliases
for PF4V1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Platelet Factor 4 Variant 11 2 | | PF4-ALT2 | | CXCL4L11 2 3 | | PF4A2 | | CXCL4V11 2 3 | | C-X-C Motif Chemokine 42 | | SCYB4V11 2 3 | | Platelet Factor 4 Variant2 | | PF4alt2 3 | | Platelet Factor 4, Variant 1 (PF4-Like)2 | | PF4var12 3 | | C-X-C Motif Chemokine 4 Variant3 |
Export aliases for PF4V1 gene to outside databasesPrevious GC identifers: GC04P074708 GC04P074958 GC04P075119 GC04P075185 GC04P075084 GC04P070530 |
Summaries
for PF4V1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro)
|
Genomic Views
for PF4V1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PF4V1 gene promoter:
STAT1 AML1a STAT4 ATF-2 STAT1beta MyoD STAT1alpha Evi-1 STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for PF4V1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PF4V1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q12-q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q12-q21PF4V1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P074718: view genomic region
(about GC identifiers)
Start:
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74,718,906 bp from pter |
End:
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74,720,198 bp from pter |
Size:
|
1,293 bases |
Orientation:
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plus strand |
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Proteins
for PF4V1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720 (See
protein sequence)Recommended Name: Platelet factor 4 variant precursor Size: 104 amino acids; 11553 Da
Subcellular location: Secreted
Mass spectrometry: Mass=8250.9; Method=Electrospray; Range=31-104; Note=Platelet factor 4 variant;Source=PubMed:15459074;
Mass spectrometry: Mass=7877.7; Method=Electrospray; Range=34-104; Note=Platelet factor 4 variant(4-74);Source=PubMed:15459074;
Mass spectrometry: Mass=7805.8; Method=Electrospray; Range=35-104; Note=Platelet factor 4 variant(5-74);Source=PubMed:15459074;
Mass spectrometry: Mass=7678.6; Method=Electrospray; Range=36-104; Note=Platelet factor 4 variant(6-74);Source=PubMed:15459074;
Secondary accessions: A1L4S0Explore the universe of human proteins at neXtProt for PF4V1: NX_P10720
Post-translational modifications:
The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The mostabundant form is Platelet factor 4 variant(5-74)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P10720
PF4V1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002611.1
ENSEMBL proteins: ENSP00000226524
Human Recombinant Protein Products for PF4V1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
PF4V1 for ontologies About GeneDecksing
PF4V1 Antibody Products:
Assay Products for PF4V1: |
Protein
Domains /
Families
for PF4V1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PF4V1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P10720ProtoNet protein and cluster: P10720 UniProtKB/Swiss-Prot: PF4V_HUMAN, P10720Similarity: Belongs to the intercrine alpha (chemokine CxC) family |
Function
for PF4V1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PF4V_HUMAN, P10720Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro) Genatlas biochemistry entry for PF4V1:platelet factor 4,variant 1 (see IMC2@)
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008009 | chemokine activity |
IEA | -- | | GO:0008201 | heparin binding |
IEA | -- |
PF4V1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for PF4V1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PF4V1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PF4V1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PF4V1 (NM_002620) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PF4V1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PF4V1 |
|
Pathways & Interactions
for PF4V1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PEDF Induced Signaling | | | 2 | Rho Family GTPases | | | 3 | PAK Pathway | | | 4 | Akt Signaling | | | 5 | Chemokine Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PF4V1 (see all 17)
2 
Kegg Pathways (Kegg details for PF4V1):
PF4V1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PF4V1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/19 Interacting proteins for PF4V1 (P107203 ENSP000002265244) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006955 | immune response |
IEA | -- |
PF4V1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PF4V1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PF4V1
Search CenterWatch for drugs/clinical trials and news about PF4V1 / PF4V
|
Transcripts
for PF4V1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PF4V1 gene: NM_002620.2 Unigene Cluster for PF4V1: Platelet factor 4 variant 1 Hs.72933 Unigene Representative Sequence: NM_0026201 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000226524(uc003hhg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PF4V1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PF4V1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PF4V1 (NM_002620) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PF4V1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PF4V1 |
Additional cDNA sequence: BC130653.1 BC130657.1 1 DOTS entry: DT.403173 2 AceView cDNA sequences: C02136 NM_002620
GeneLoc Exon Structure
|
Expression
for PF4V1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PF4V1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTCCGCAG
About this image
See PF4V1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PF4V1
SOURCE GeneReport for Unigene cluster: Hs.72933
SABiosciences Expression via Pathway-Focused PCR Arrays including PF4V1: | Inflammatory Response & Autoimmunity 384HT in human mouse rat | | Chemokines & Receptors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PF4V1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PF4V1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PF4V1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PF4V1 |
Orthologs
for PF4V1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PF4V1 gene from 4/5 species (see all 5) About this table
Species with no ortholog for PF4V1
ENSEMBL Gene Tree for PF4V1 (if available)
TreeFam Gene Tree for PF4V1 (if available) |
Paralogs
for PF4V1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PF4V1 gene
- CXCL32 CXCL52 PPBP2 PF42 CXCL12 IL82 CXCL22 CXCL62
9 SIMAP similar genes for PF4V1 using alignment to 1 protein entry: PF4V_HUMAN:PF4 CXCL10 CXCL1 CXCL2 CXCL3 IL8
PPBP CXCL5 CXCL6
PF4V1 for paralogs About GeneDecksing
|
Genomic Variants
for PF4V1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PF4V1 (74718906 - 74720198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PF4V1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PF4V1 |
|
Disorders
/ Diseases
for PF4V1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PF4V1 for disorders About GeneDecksing
OMIM gene information: 173461
OMIM disorders: --
5  diseases for PF4V1: About MalaCardscystic fibrosis lung disease cystic fibrosis fibrosis hepatitis b
hepatitis
Human Genome Epidemiology (HuGE) Navigator: PF4V1 (2 documents)
Export disorders for PF4V1 gene to outside databases
|
Publications
for PF4V1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PF4V1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with PF4V1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of PF4var1, a human gene variant of platelet factor 4. (PubMed id 2725510)1, 2, 3 Green C.J.... Johnson P.H. (1989)
- Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. (PubMed id 15459074)1, 2 Struyf S.... Strieter R.M. (2004)
- Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)1, 2 Eisman R.... Poncz M. (1990)
- PF-4var/CXCL4L1 predicts outcome in stable coronary ar tery disease patients with preserved left ventricular function. (PubMed id 22384011)1 De Sutter J....Van Damme J. (2012)
- Angiostatic and chemotactic activities of the CXC che mokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. (PubMed id 20980681)1 Struyf S....Van Damme J. (2011)
- CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. (PubMed id 20961394)1 Sarabi A....Von Hundelshausen P. (2011)
- The role of the CXC chemokines platelet factor-4 (CXC L4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and ca ncer. (PubMed id 21111666)1 Vandercappellen J....Struyf S. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Functional divergence between 2 chemokines is conferr ed by single amino acid change. (PubMed id 20688960)1 Dubrac A....Prats H. (2010)
- Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)1 Hillian A.D....Drumm M.L. (2008)
|
External Searches for PF4V1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PF4V1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PF4V1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PF4V1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PF4V1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PF4V1 gene:
Search GeneIP for patents involving PF4V1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PF4V1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for PF4V1 | | OriGene shRNA RFP for PF4V1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PF4V1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PF4V1 | | | OriGene Protein Over-expression Lysate for PF4V1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PF4V1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PF4V1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PF4V1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PF4V1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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