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Aliases for PF4V1 Gene

Aliases for PF4V1 Gene

  • Platelet Factor 4 Variant 1 2 3
  • CXCL4L1 3 4
  • CXCL4V1 3 4
  • PF4var1 3 4
  • SCYB4V1 3 4
  • PF4alt 3 4
  • Platelet Factor 4, Variant 1 (PF4-Like) 3
  • C-X-C Motif Chemokine 4 Variant 4
  • Platelet Factor 4 Variant 3
  • C-X-C Motif Chemokine 4 3
  • PF4-ALT 3
  • PF4A 3

External Ids for PF4V1 Gene

Summaries for PF4V1 Gene

GeneCards Summary for PF4V1 Gene

PF4V1 (Platelet Factor 4 Variant 1) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for PF4V1 Gene

  • Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PF4V1 Gene

Genomics for PF4V1 Gene

Genomic Location for PF4V1 Gene

Start:
73,853,189 bp from pter
End:
73,854,481 bp from pter
Size:
1,293 bases
Orientation:
Plus strand

Genomic View for PF4V1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PF4V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PF4V1 Gene

Regulatory Elements for PF4V1 Gene

Proteins for PF4V1 Gene

  • Protein details for PF4V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10720-PF4V_HUMAN
    Recommended name:
    Platelet factor 4 variant
    Protein Accession:
    P10720
    Secondary Accessions:
    • A1L4S0

    Protein attributes for PF4V1 Gene

    Size:
    104 amino acids
    Molecular mass:
    11553 Da
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Binding to heparin is much weaker than in the close homolog PF4/CXCL4

    Three dimensional structures from OCA and Proteopedia for PF4V1 Gene

neXtProt entry for PF4V1 Gene

Proteomics data for PF4V1 Gene at MOPED

Post-translational modifications for PF4V1 Gene

  • The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74)

Other Protein References for PF4V1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PF4V1 Gene

Domains for PF4V1 Gene

Protein Domains for PF4V1 Gene

Suggested Antigen Peptide Sequences for PF4V1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10720

UniProtKB/Swiss-Prot:

PF4V_HUMAN
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.:
    • P10720
genes like me logo Genes that share domains with PF4V1: view

No data available for Gene Families for PF4V1 Gene

Function for PF4V1 Gene

Molecular function for PF4V1 Gene

GENATLAS Biochemistry: platelet factor 4,variant 1 (see IMC2@)
UniProtKB/Swiss-Prot Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).

Gene Ontology (GO) - Molecular Function for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IBA --
GO:0008201 heparin binding IBA --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with PF4V1: view

Phenotypes for PF4V1 Gene

GenomeRNAi human phenotypes for PF4V1:
genes like me logo Genes that share phenotypes with PF4V1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PF4V1 Gene

Localization for PF4V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PF4V1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PF4V1 Gene COMPARTMENTS Subcellular localization image for PF4V1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with PF4V1: view

Pathways for PF4V1 Gene

genes like me logo Genes that share pathways with PF4V1: view

Interacting Proteins for PF4V1 Gene

Gene Ontology (GO) - Biological Process for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0032496 response to lipopolysaccharide IBA --
genes like me logo Genes that share ontologies with PF4V1: view

Transcripts for PF4V1 Gene

mRNA/cDNA for PF4V1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PF4V1 Gene

Platelet factor 4 variant 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PF4V1 Gene

No ASD Table

Relevant External Links for PF4V1 Gene

GeneLoc Exon Structure for
PF4V1
ECgene alternative splicing isoforms for
PF4V1

Expression for PF4V1 Gene

mRNA expression in normal human tissues for PF4V1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PF4V1 Gene

This gene is overexpressed in Whole Blood (28.3) and Spleen (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PF4V1 Gene

SOURCE GeneReport for Unigene cluster for PF4V1 Gene Hs.72933

genes like me logo Genes that share expressions with PF4V1: view

No data available for mRNA Expression by UniProt/SwissProt for PF4V1 Gene

Orthologs for PF4V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PF4V1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PF4V1 35
  • 96.79 (n)
  • 94.23 (a)
PF4V1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PF4 36
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pf4 36
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
OneToMany
Species with no ortholog for PF4V1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PF4V1 Gene

ENSEMBL:
Gene Tree for PF4V1 (if available)
TreeFam:
Gene Tree for PF4V1 (if available)

Paralogs for PF4V1 Gene

Paralogs for PF4V1 Gene

Selected SIMAP similar genes for PF4V1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PF4V1: view

Variants for PF4V1 Gene

Sequence variations from dbSNP and Humsavar for PF4V1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4812 -- 73,853,851(+) CCAGG(C/G)ACATC reference, missense
rs872914 -- 73,852,384(+) TGTGG(A/G)ATTCT upstream-variant-2KB
rs941757 -- 73,853,128(+) GGCAG(C/G)TGCCC upstream-variant-2KB
rs941758 -- 73,853,224(+) TCCAC(A/C)CCAGG upstream-variant-2KB
rs2145609 -- 73,852,672(+) TTTTT(A/C)TAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PF4V1 Gene

Variant ID Type Subtype PubMed ID
nsv4389 CNV Insertion 18451855

Relevant External Links for PF4V1 Gene

HapMap Linkage Disequilibrium report
PF4V1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PF4V1 Gene

Disorders for PF4V1 Gene

Relevant External Links for PF4V1

Genetic Association Database (GAD)
PF4V1
Human Genome Epidemiology (HuGE) Navigator
PF4V1
genes like me logo Genes that share disorders with PF4V1: view

No data available for UniProtKB/Swiss-Prot for PF4V1 Gene

Publications for PF4V1 Gene

  1. Identification and characterization of PF4var1, a human gene variant of platelet factor 4. (PMID: 2725510) Green C.J. … Johnson P.H. (Mol. Cell. Biol. 1989) 2 3 4
  2. Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1. (PMID: 23536183) Kuo J.H. … Sue S.C. (J. Biol. Chem. 2013) 3 4
  3. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. (PMID: 15459074) Struyf S. … Strieter R.M. (Circ. Res. 2004) 3 4
  4. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PMID: 18563170) Hillian A.D. … Drumm M.L. (Genes Immun. 2008) 3 48
  5. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PMID: 1695112) Eisman R. … Poncz M. (Blood 1990) 3 4

Products for PF4V1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PF4V1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PF4V1
    • Block miRNA regulation of PF4V1 using miScript Target Protectors

    Sources for PF4V1 Gene

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