Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PF4V1 Gene

Aliases for PF4V1 Gene

  • Platelet Factor 4 Variant 1 2 3 5
  • CXCL4L1 3 4
  • CXCL4V1 3 4
  • PF4var1 3 4
  • SCYB4V1 3 4
  • PF4alt 3 4
  • Platelet Factor 4, Variant 1 (PF4-Like) 3
  • C-X-C Motif Chemokine 4 Variant 4
  • Platelet Factor 4 Variant 3
  • C-X-C Motif Chemokine 4 3
  • PF4-ALT 3
  • PF4A 3

External Ids for PF4V1 Gene

Previous GeneCards Identifiers for PF4V1 Gene

  • GC04P074708
  • GC04P074958
  • GC04P075119
  • GC04P075185
  • GC04P075084
  • GC04P074718
  • GC04P070530

Summaries for PF4V1 Gene

Entrez Gene Summary for PF4V1 Gene

  • The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for PF4V1 Gene

PF4V1 (Platelet Factor 4 Variant 1) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and PAK Pathway. GO annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for PF4V1 Gene

  • Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PF4V1 Gene

Genomics for PF4V1 Gene

Regulatory Elements for PF4V1 Gene

Enhancers for PF4V1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G073702 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -148.5 -148491 3.8 PKNOX1 CREB3L1 ARNT SIN3A FEZF1 YY1 ZNF766 FOS KLF13 REST CXCL8 CXCL2 CXCL3 PF4V1 LOC105377272 CXCL5 MTHFD2L CXCL1 ANKRD17 RASSF6
GH04G073739 1.4 Ensembl ENCODE dbSUPER 14.6 -112.5 -112529 2.7 HDAC1 TBP ATF1 FOXA2 SIN3A FEZF1 ZBTB40 ZNF766 GATA2 ZNF366 PF4V1 CXCL8 GC04P073743
GH04G073730 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -119.8 -119780 5.2 HDAC1 PKNOX1 ATF1 TBL1XR1 BMI1 ZBTB40 ZNF766 CBX5 FOS RELB CXCL8 CXCL2 CXCL3 PF4V1 MTHFD2L ANKRD17 CXCL1 LOC105377272
GH04G073853 0.7 Ensembl 28 +0.4 412 0.8 ZNF263 CTCF ZNF10 FEZF1 ZNF398 ZIC2 HIC1 ZNF610 ZBTB48 ZNF341 PF4V1 CXCL1
GH04G073891 1.1 FANTOM5 Ensembl ENCODE 16.3 +38.8 38799 0.8 SCRT2 CEBPB EP300 CXCL3 CXCL8 PF4V1 EREG MTHFD2L PPBP CXCL2 CXCL1 HNRNPA1P55
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PF4V1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PF4V1 Gene

Chromosome:
4
Start:
73,853,189 bp from pter
End:
73,854,481 bp from pter
Size:
1,293 bases
Orientation:
Plus strand

Genomic View for PF4V1 Gene

Genes around PF4V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PF4V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PF4V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PF4V1 Gene

Proteins for PF4V1 Gene

  • Protein details for PF4V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10720-PF4V_HUMAN
    Recommended name:
    Platelet factor 4 variant
    Protein Accession:
    P10720
    Secondary Accessions:
    • A1L4S0

    Protein attributes for PF4V1 Gene

    Size:
    104 amino acids
    Molecular mass:
    11553 Da
    Quaternary structure:
    • Homotetramer.
    Miscellaneous:
    • Binding to heparin is much weaker than in the close homolog PF4/CXCL4.

    Three dimensional structures from OCA and Proteopedia for PF4V1 Gene

neXtProt entry for PF4V1 Gene

Post-translational modifications for PF4V1 Gene

  • The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PF4V1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PF4V1
  • Cloud-Clone Corp. Antibodies for PF4V1
  • Santa Cruz Biotechnology (SCBT) Antibodies for PF4V1

No data available for DME Specific Peptides for PF4V1 Gene

Domains & Families for PF4V1 Gene

Suggested Antigen Peptide Sequences for PF4V1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10720

UniProtKB/Swiss-Prot:

PF4V_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with PF4V1: view

No data available for Gene Families for PF4V1 Gene

Function for PF4V1 Gene

Molecular function for PF4V1 Gene

GENATLAS Biochemistry:
platelet factor 4,variant 1 (see IMC2@)
UniProtKB/Swiss-Prot Function:
Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).

Gene Ontology (GO) - Molecular Function for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IBA --
GO:0008201 heparin binding IBA --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with PF4V1: view

Phenotypes for PF4V1 Gene

genes like me logo Genes that share phenotypes with PF4V1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PF4V1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PF4V1 Gene

Localization for PF4V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PF4V1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PF4V1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with PF4V1: view

Pathways & Interactions for PF4V1 Gene

genes like me logo Genes that share pathways with PF4V1: view

Gene Ontology (GO) - Biological Process for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with PF4V1: view

No data available for SIGNOR curated interactions for PF4V1 Gene

Drugs & Compounds for PF4V1 Gene

No Compound Related Data Available

Transcripts for PF4V1 Gene

mRNA/cDNA for PF4V1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PF4V1 Gene

Platelet factor 4 variant 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PF4V1

Alternative Splicing Database (ASD) splice patterns (SP) for PF4V1 Gene

No ASD Table

Relevant External Links for PF4V1 Gene

GeneLoc Exon Structure for
PF4V1
ECgene alternative splicing isoforms for
PF4V1

Expression for PF4V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PF4V1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PF4V1 Gene

This gene is overexpressed in Whole Blood (x28.3) and Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for PF4V1 Gene

This gene is overexpressed in Monocytes (29.3), Serum (16.1), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PF4V1 Gene



Protein tissue co-expression partners for PF4V1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PF4V1 Gene:

PF4V1

SOURCE GeneReport for Unigene cluster for PF4V1 Gene:

Hs.72933

Evidence on tissue expression from TISSUES for PF4V1 Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with PF4V1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PF4V1 Gene

Orthologs for PF4V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PF4V1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PF4V1 34 35
  • 96.79 (n)
mouse
(Mus musculus)
Mammalia Pf4 35
  • 65 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PF4 35
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 41 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
OneToMany
Species where no ortholog for PF4V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PF4V1 Gene

ENSEMBL:
Gene Tree for PF4V1 (if available)
TreeFam:
Gene Tree for PF4V1 (if available)

Paralogs for PF4V1 Gene

Paralogs for PF4V1 Gene

(9) SIMAP similar genes for PF4V1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PF4V1: view

Variants for PF4V1 Gene

Sequence variations from dbSNP and Humsavar for PF4V1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000494433 -- 73,854,948(+) CTTCT(A/G)CCTTT downstream-variant-500B
rs1000633386 -- 73,854,704(+) ATTAC(C/T)ACAAA downstream-variant-500B
rs1003176557 -- 73,852,422(+) ATCAT(C/T)CTCAC upstream-variant-2KB
rs1004772460 -- 73,854,296(+) TAAAA(C/T)TTCCA utr-variant-3-prime
rs1005140536 -- 73,851,858(+) ATAAA(C/T)GTTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PF4V1 Gene

Variant ID Type Subtype PubMed ID
nsv1001725 CNV gain 25217958
nsv4389 CNV insertion 18451855

Variation tolerance for PF4V1 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PF4V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PF4V1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PF4V1 Gene

Disorders for PF4V1 Gene

Relevant External Links for PF4V1

Genetic Association Database (GAD)
PF4V1
Human Genome Epidemiology (HuGE) Navigator
PF4V1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PF4V1

No disorders were found for PF4V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PF4V1 Gene

Publications for PF4V1 Gene

  1. Identification and characterization of PF4var1, a human gene variant of platelet factor 4. (PMID: 2725510) Green C.J. … Johnson P.H. (Mol. Cell. Biol. 1989) 2 3 4 64
  2. Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1. (PMID: 23536183) Kuo J.H. … Sue S.C. (J. Biol. Chem. 2013) 3 4 64
  3. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PMID: 18563170) Hillian A.D. … Drumm M.L. (Genes Immun. 2008) 3 46 64
  4. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. (PMID: 15459074) Struyf S. … Strieter R.M. (Circ. Res. 2004) 3 4 64
  5. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PMID: 1695112) Eisman R. … Poncz M. (Blood 1990) 3 4 64

Products for PF4V1 Gene

  • Addgene plasmids for PF4V1

Sources for PF4V1 Gene

Content
Loading form....