Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PF4V1 Gene

Aliases for PF4V1 Gene

  • Platelet Factor 4 Variant 1 2 3 5
  • CXCL4L1 3 4
  • CXCL4V1 3 4
  • PF4var1 3 4
  • SCYB4V1 3 4
  • PF4alt 3 4
  • Platelet Factor 4, Variant 1 (PF4-Like) 3
  • C-X-C Motif Chemokine 4 Variant 4
  • C-X-C Motif Chemokine 4 3
  • PF4-ALT 3
  • PF4A 3

External Ids for PF4V1 Gene

Previous GeneCards Identifiers for PF4V1 Gene

  • GC04P074708
  • GC04P074958
  • GC04P075119
  • GC04P075185
  • GC04P075084
  • GC04P074718
  • GC04P070530

Summaries for PF4V1 Gene

Entrez Gene Summary for PF4V1 Gene

  • The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for PF4V1 Gene

PF4V1 (Platelet Factor 4 Variant 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and PEDF Induced Signaling. GO annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for PF4V1 Gene

  • Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PF4V1 Gene

Genomics for PF4V1 Gene

Regulatory Elements for PF4V1 Gene

Enhancers for PF4V1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PF4V1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PF4V1 Gene

73,853,189 bp from pter
73,854,481 bp from pter
1,293 bases
Plus strand

Genomic View for PF4V1 Gene

Genes around PF4V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PF4V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PF4V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PF4V1 Gene

Proteins for PF4V1 Gene

  • Protein details for PF4V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Platelet factor 4 variant
    Protein Accession:
    Secondary Accessions:
    • A1L4S0

    Protein attributes for PF4V1 Gene

    104 amino acids
    Molecular mass:
    11553 Da
    Quaternary structure:
    • Homotetramer.
    • Binding to heparin is much weaker than in the close homolog PF4/CXCL4.

    Three dimensional structures from OCA and Proteopedia for PF4V1 Gene

neXtProt entry for PF4V1 Gene

Proteomics data for PF4V1 Gene at MOPED

Post-translational modifications for PF4V1 Gene

  • The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PF4V1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PF4V1

No data available for DME Specific Peptides for PF4V1 Gene

Domains & Families for PF4V1 Gene

Protein Domains for PF4V1 Gene

Suggested Antigen Peptide Sequences for PF4V1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine alpha (chemokine CxC) family.
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with PF4V1: view

No data available for Gene Families for PF4V1 Gene

Function for PF4V1 Gene

Molecular function for PF4V1 Gene

GENATLAS Biochemistry:
platelet factor 4,variant 1 (see IMC2@)
UniProtKB/Swiss-Prot Function:
Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).

Phenotypes for PF4V1 Gene

genes like me logo Genes that share phenotypes with PF4V1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PF4V1 Gene

Localization for PF4V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PF4V1 Gene


Subcellular locations from

Jensen Localization Image for PF4V1 Gene COMPARTMENTS Subcellular localization image for PF4V1 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for PF4V1 Gene

Pathways & Interactions for PF4V1 Gene

genes like me logo Genes that share pathways with PF4V1: view

Interacting Proteins for PF4V1 Gene

Gene Ontology (GO) - Biological Process for PF4V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0030168 platelet activation IEA --
GO:0032496 response to lipopolysaccharide IBA --
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with PF4V1: view

No data available for SIGNOR curated interactions for PF4V1 Gene

Drugs & Compounds for PF4V1 Gene

No Compound Related Data Available

Transcripts for PF4V1 Gene

mRNA/cDNA for PF4V1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PF4V1 Gene

Platelet factor 4 variant 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PF4V1 Gene

No ASD Table

Relevant External Links for PF4V1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PF4V1 Gene

mRNA expression in normal human tissues for PF4V1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PF4V1 Gene

This gene is overexpressed in Whole Blood (x28.3) and Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for PF4V1 Gene

This gene is overexpressed in Monocytes (29.3), Serum (16.1), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PF4V1 Gene

SOURCE GeneReport for Unigene cluster for PF4V1 Gene Hs.72933

genes like me logo Genes that share expression patterns with PF4V1: view

Protein tissue co-expression partners for PF4V1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PF4V1 Gene

Orthologs for PF4V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PF4V1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PF4V1 35
  • 96.79 (n)
  • 94.23 (a)
PF4V1 36
  • 94 (a)
(Bos Taurus)
Mammalia PF4 36
  • 51 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
(Mus musculus)
Mammalia Pf4 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
-- 36
  • 41 (a)
-- 36
  • 31 (a)
(Gallus gallus)
Aves -- 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
Species with no ortholog for PF4V1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PF4V1 Gene

Gene Tree for PF4V1 (if available)
Gene Tree for PF4V1 (if available)

Paralogs for PF4V1 Gene

Paralogs for PF4V1 Gene

(9) SIMAP similar genes for PF4V1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PF4V1: view

Variants for PF4V1 Gene

Sequence variations from dbSNP and Humsavar for PF4V1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4812 -- 73,853,851(+) CCAGG(C/G)ACATC reference, missense
rs872914 -- 73,852,384(+) TGTGG(A/G)ATTCT upstream-variant-2KB
rs941757 -- 73,853,128(+) GGCAG(C/G)TGCCC upstream-variant-2KB
rs941758 -- 73,853,224(+) TCCAC(A/C)CCAGG upstream-variant-2KB
rs2233649 -- 73,853,917(+) GAGTC(C/T)TCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PF4V1 Gene

Variant ID Type Subtype PubMed ID
nsv4389 CNV Insertion 18451855

Variation tolerance for PF4V1 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PF4V1 Gene

Disorders for PF4V1 Gene

Relevant External Links for PF4V1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PF4V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PF4V1 Gene

Publications for PF4V1 Gene

  1. Identification and characterization of PF4var1, a human gene variant of platelet factor 4. (PMID: 2725510) Green C.J. … Johnson P.H. (Mol. Cell. Biol. 1989) 2 3 4 67
  2. The roles and potential therapeutic implications of CXCL4 and its variant CXCL4L1 in the pathogenesis of chronic liver allograft dysfunction. (PMID: 25466649) Li J. … Lau W.Y. (Cytokine Growth Factor Rev. 2015) 3
  3. The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown. (PMID: 25711636) Abu El-Asrar A.M. … Struyf S. (Invest. Ophthalmol. Vis. Sci. 2015) 3
  4. CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase. (PMID: 24469069) Van Raemdonck K. … Struyf S. (Angiogenesis 2014) 3
  5. Angiostatic, tumor inflammatory and anti-tumor effects of CXCL4(47-70) and CXCL4L1(47-70) in an EGF-dependent breast cancer model. (PMID: 25373734) Van Raemdonck K. … Struyf S. (Oncotarget 2014) 3

Products for PF4V1 Gene

Sources for PF4V1 Gene