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PF4 Gene

protein-coding GIFtS: 62
GCID: GC04M074836

Platelet Factor 4

(Previous name: platelet factor 4)

See PF4-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Platelet Factor 4¹ ²		C-X-C Motif Chemokine 4² ³
Chemokine (C-X-C Motif) Ligand 4¹ ²		iroplact²
CXCL4² ³		oncostatin-A²
PF-4² ³		Iroplact³
SCYB4² ³		Oncostatin-A³

External Ids:	HGNC: 8861¹	Entrez Gene: 5196²	Ensembl: ENSG00000163737⁷	OMIM: 173460⁵	UniProtKB: P02776³

Export aliases for PF4 gene to outside databases

Previous GC identifers: GC04M075086 GC04M075247 GC04M075313 GC04M075211 GC04M070658

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PF4 Gene:

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of

activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet

aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of

hematopoiesis, angiogenesis and T-cell function. (provided by RefSeq, Mar 2012)

GeneCards Summary for PF4 Gene:

PF4 (platelet factor 4) is a protein-coding gene. Diseases associated with PF4 include tuberculosis, and acute poststreptococcal glomerulonephritis. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776

Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds

more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for

neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor

than the longer form

Gene Wiki entry for PF4 (Platelet factor 4) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000004.11 NT_016354.20 NC_018915.2

Regulatory elements:

Regulatory transcription factor binding sites in the PF4 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PF4 promoter sequence

Search Chromatin IP Primers for PF4

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PF4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q12-q21

PF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PF4 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M074836: view genomic region (about GC identifiers)

Start:	74,846,794 bp from pter	End:	74,847,841 bp from pter
Size:	1,048 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776 (See protein sequence)

Recommended Name: Platelet factor 4 precursor

Size: 101 amino acids; 10845 Da

Subunit: Homotetramer

Mass spectrometry: Mass=7765; Method=Electrospray; Range=32-101; Source=PubMed:7644496;

Mass spectrometry: Mass=6033; Method=Electrospray; Range=48-101; Note=Short form; Source=PubMed:7644496;

Selected PDB 3D structures from and Proteopedia for PF4 (see all 7):

1DN3 (3D)

1F9Q (3D)

1F9R (3D)

1F9S (3D)

1PFM (3D)

1PFN (3D)

Secondary accessions: Q53X61 Q9UC64 Q9UC65

Explore the universe of human proteins at neXtProt for PF4: NX_P02776

Explore proteomics data for PF4 at MOPED

See PF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002610.1

ENSEMBL proteins:

ENSP00000296029

Reactome Protein details: P02776

PF4 Human Recombinant Protein Products:

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	antibodies-online proteins for PF4 (85 products)
	Search antibodies-online for peptides for PF4

PF4 Antibody Products:

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PF4 Assay Products:

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	Cloud-Clone Corp. ELISAs for PF4 Cloud-Clone Corp. CLIAs for PF4
	Search eBioscience for ELISAs for PF4
	antibodies-online kits for PF4 (54 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR027222 PF4

IPR001811 Chemokine_IL8-like_dom

IPR001089 Chemokine_CXC

IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P02776

ProtoNet protein and cluster: P02776

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

Find genes that share domains with PF4 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: PLF4_HUMAN, P02776

Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds

more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for

neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor

than the longer form

Genatlas biochemistry entry for PF4:

platelet factor 4 (see IMC2@)

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	TAS	12466273
GO:0008201	heparin binding	IDA	9531587
GO:0048248	CXCR3 chemokine receptor binding	IDA	12782716

Find genes that share ontologies with PF4 About GenesLikeMe

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pf4):

hematopoietic system

homeostasis/metabolism

Find genes that share phenotypes with PF4 About GenesLikeMe

Animal Models:
MGI mouse knock-out Pf4^tm1Mako for PF4

genOway: Develop your customized and physiologically relevant rodent model for PF4

miRNA Products:		Block miRNA regulation of human, mouse, rat PF4 using miScript Target Protectors
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

PLF4_HUMAN, P02776: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
cytoskeleton	1
lysosome	1
nucleus	1
plasma membrane	1
vacuole	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0031093	platelet alpha granule lumen	TAS	--

Find genes that share ontologies with PF4 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PF4 About (see all 14)

See pathways by source

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by

SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Regulation of Innate Immune Cells	0.94	IL-6 Pathway	0.61
MIF Mediated Glucocorticoid Regulation	0.94	STAT3 Pathway	0.47
PEDF Induced Signaling	0.73	Endothelin-1 Signaling Pathway	0.46
all-trans-Retinoic Acid Signaling in Brain	0.71	Cytokine-cytokine receptor interaction	0.43

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Chemokine receptors bind chemokines

0.81

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

0.81

Chemokine Signaling

Chemokine Signaling

0.33

Chemokine signaling pathway

0.33

Peptide ligand-binding receptors

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Find genes that share SuperPaths with PF4 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for PF4

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PF4 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

1 BioSystems Pathway for PF4

CXCR3-mediated signaling events

5 Reactome Pathways for PF4

	Platelet degranulation
	Chemokine receptors bind chemokines
	G alpha (i) signalling events
	Cell surface interactions at the vascular wall
	Common Pathway

2 Kegg Pathways (Kegg details for PF4):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

Pathway & Disease-focused RT² Profiler PCR Arrays including PF4 (see all 8):

Endothelial Cell Biology in human mouse rat

Angiogenic Growth Factors in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Cytokines & Chemokines in human mouse rat

Angiogenesis in human mouse rat

Interactions:

GeneGlobe Interaction Network for PF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PF4 (P02776^{2, 3} ENSP00000296029⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 71)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL8	P10145³, ENSP00000306512⁴	I2D: score=3 STRING: ENSP00000306512
PROC	P04070³, ENSP00000234071⁴	I2D: score=2 STRING: ENSP00000234071
SRGN	P10124³, ENSP00000242465⁴	I2D: score=2 STRING: ENSP00000242465
CXCL12	P48061³, ENSP00000363548⁴	I2D: score=1 STRING: ENSP00000363548
CCL5	P13501³, ENSP00000293272⁴	I2D: score=2 STRING: ENSP00000293272

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Gene Ontology (GO): Selected biological process terms (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0006955	immune response	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0010628	positive regulation of gene expression	IDA	10666185
GO:0010744	positive regulation of macrophage derived foam cell differentiation	IDA	17244792

Find genes that share ontologies with PF4 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for PF4 (PLF4)

1 DrugBank Compound for PF4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Drotrecogin alfa	Anticoagulant protein C (see all 4)	60202-16-6	target	--	11259926

Selected Novoseek inferred chemical compound relationships for PF4 gene (see all 114) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparin	87.7	940	8282825 (7), 17257993 (6), 8857955 (6), 1537108 (6) (see all 99)
danaparoid	84.1	2	18983520 (1), 16109780 (1)
hirudin	80.3	7	16404704 (1), 9024148 (1), 18541684 (1), 1832654 (1) (see all 5)
fibrinopeptide a	75.6	11	7646626 (2), 7539015 (2), 7637955 (1), 1720884 (1) (see all 6)
txb2	75.1	95	8329704 (5), 1840363 (3), 10475099 (3), 15613179 (2) (see all 46)
fondaparinux	72.6	12	18262226 (3), 9518042 (1), 15317404 (1), 16359523 (1) (see all 10)
rantes	68.4	87	15459010 (9), 15899984 (5), 19201759 (3), 7531729 (3) (see all 38)
fibrinogen	67.9	72	17351162 (3), 8996302 (2), 11077138 (2), 7553675 (2) (see all 50)
tecogalan sodium	65.4	2	9409948 (1), 10439927 (1)
adp	65.1	49	7843648 (3), 12889011 (3), 9863147 (2), 11782701 (2) (see all 30)

Find genes that share compounds with PF4 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PF4 gene:

NM_002619.3

Unigene Cluster for PF4:

Platelet factor 4

Hs.81564 [show with all ESTs]

Unigene Representative Sequence: NM_002619

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000296029(uc003hhi.2)

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		QuantiFast Probe-based Assays in human, mouse, rat PF4

Additional mRNA sequence:

BC093965.1 BC112093.1 CR407677.1 M25897.1

2 DOTS entries:

DT.113152 DT.121223983

Selected AceView cDNA sequences (see all 30):

AI078445 CR407677 BQ023965 N92470 AI739539 NM_002619 T28407 AJ705588

AA024823 AA152486 BX114245 M25897 AI185569 T84282 W17158 AI766542

CA426108 BV177626 AA024929 T85166 AI400188 AI470327 R83715 AA152485

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

PF4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 10) fully expand


Blood (Hematopoietic System) fully expand to see all 3 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow

Bone (Muscoskeletal System) fully expand to see all 2 entries
Mesenchymal Condensate Cells Zeugopod
Bone Marrow

Brain (Nervous System) fully expand to see all 2 entries
Medulla Oblongata

Neural Crest (Gastrulation Derivatives)
Cranial Neural Crest Cells Branchial Arch 1

Cartilage (Muscoskeletal System)
Mesenchymal Condensate Cells Zeugopod

PF4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

PF4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.81564

Pathway & Disease-focused RT² Profiler PCR Arrays including PF4 (see all 8):

Endothelial Cell Biology in human mouse rat

Angiogenic Growth Factors in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Cytokines & Chemokines in human mouse rat

Angiogenesis in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for PF4 OriGene qSTAR qPCR primer pairs in human, mouse for PF4
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PF4
		QuantiTect SYBR Green Assays in human, mouse, rat PF4
		QuantiFast Probe-based Assays in human, mouse, rat PF4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PF4 gene from Selected species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pf4^{1 , 5}	platelet factor 4^{1, 5}	79.22(n)¹ 75.32(a)¹		5 (44.78 cM)⁵ 56744¹ NM_019932.4¹ NP_064316.1¹ 90772435⁵
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	33(a)	1 → many	4(50379773-50381069)
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	32(a)	1 → many	6(60123888-60134622)

ENSEMBL Gene Tree for PF4 (if available)
TreeFam Gene Tree for PF4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PF4 gene

PPBP² CXCL1² PF4V1² CXCL6² CXCL3² CXCL5² CXCL2² IL8²

9 SIMAP similar genes for PF4 using alignment to 1 protein entry: PLF4_HUMAN:

PF4V1 PPBP CXCL5 CXCL10 CXCL6 CXCL1

CXCL2 IL8 CXCL3

Find genes that share paralogs with PF4 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147843417^1,2		--	74724385(+)	`CCAACA/GTATTC`	1	--	ds500¹		0	--	--	--	--
rs111665740^1,2	C,F	--	74724455(+)	`GAGATG/ATGACA`	1	--	ds500¹		1		CSA	2
rs183996563^1,2		--	74724474(+)	`AGAGGC/TTGGAG`	1	--	ds500¹		0	--	--	--	--
rs188770400^1,2		--	74724524(+)	`AGAACA/GTAGAT`	1	--	ds500¹		0	--	--	--	--
rs150287185^1,2		--	74724631(+)	`CCCACC/TTGGGA`	1	--	ds500¹		0	--	--	--	--
rs112444347^1,2	C	--	74724797(+)	`AAAAA-/CATCATCA`	1	--	cds¹		1		CSA	2
rs352004^1,2	C,F,O,H	--	74724908(-)	`TATTAC/TCTTTG`	1	--	ut3¹		26		MN NS EA NA WA CSA	2514
rs144889653^1,2		--	74724938(+)	`TGTAGA/CTATAA`	1	--	ut3¹		0	--	--	--	--
rs352005^1,2	C,F,O,H	--	74724966(-)	`ATTCAT/CGCATT`	1	--	ut3¹		14		MN NA NS EA WA	912
rs11574452^1,2	C,F,H	--	74724999(-)	`GTTATG/TCTTGG`	1	--	ut3¹		19		NA NS EA	2466
rs11574451^1,2	H	--	74725120(-)	`GTATAG/CTCAAA`	1	--	ut3¹		5		NA NS EA	460
rs180789835^1,2	C	--	74725177(+)	`AATATC/GAGAAG`	1	--	ut3¹		0	--	--	--	--
rs352006^1,2	C,F,O,A,H	--	74725215(-)	`TACTTC/TTTTTT`	1	--	ut3¹ ese³ trp³		19		EA NA NS WA CSA EU	2165
rs201608869^1,2		--	74725244(+)	`CACACA/GTAGGC`	1	--	ut3¹		0	--	--	--	--
rs200691269^1,2		--	74725266(+)	`AACTCC/TCCAAA`	2	E G	mis¹		0	--	--	--	--
rs199976537^1,2		--	74725313(+)	`AGGTCC/TAAGCA`	2	L	syn¹		0	--	--	--	--
rs201899718^1,2	C	--	74725315(+)	`GTCCAA/C/GGCAAA`	3	L V	syn¹ mis¹		0	--	--	--	--
rs114655702^1,2		--	74725317(+)	`CCAAGC/AAAATT`	2	/C /F	mis¹		1		NA	214
rs116188786^1,2		--	74725328(+)	`TTCCTT/CCCATT`	2	/G	syn¹		1		WA	216
rs117806951^1,2	C	--	74725442(+)	`GCGGGA/GGCACT`	1	--	int¹		1		EA	120
rs11574450^1,2	C,F,H	--	74725449(-)	`ATCTGT/GCAGTG`	1	--	int¹		8		NA NS EA EU	2002
rs2233648^1,2	C,F	--	74725474(-)	`CAACTG/CATGTG`	2	/L	syn¹		4		NS WA NA	5040
rs352007^1,2	C,F,A,H	--	74725630(+)	`GAGGAC/GGAGGG`	1	--	int¹ trp³		18		EA NA MN NS WA CSA EU	1171
rs116796864^1,2	C,F	--	74725936(+)	`GACCAC/TAAGTG`	2	M V	mis¹		1		EA	166
rs190601797^1,2		--	74726009(+)	`CTCATC/GCTGCG`	1	--	ut5¹		0	--	--	--	--
rs143069856^1,2		--	74726085(+)	`AATGAC/TTCCTG`	1	--	ut5¹		0	--	--	--	--
rs116253707^1,2	F	--	74726103(+)	`CCGGCA/TCGTTT`	1	--	ut5¹		1		WA	118
rs182327392^1,2		--	74726128(+)	`CTTCCA/GGTCCG`	1	--	ut5¹		0	--	--	--	--
rs13128069^1,2	H	--	74726150(+)	`TGGACA/CCCGAG`	1	--	ut5¹		4		NS EA	420
rs13151226^1,2	H	--	74726177(+)	`ACTAAG/AATAGT`	1	--	ut5¹		4		NS EA	418
rs13152788^1,2	H	--	74726184(+)	`TAGTAC/TTGGGA`	1	--	us2k¹		4		NS EA	418
rs13151248^1,2	H	--	74726191(+)	`GGGAAG/AACTTG`	1	--	us2k¹		4		NS EA	418
rs187412522^1,2		--	74726193(+)	`GAAGAC/TTTGGG`	1	--	us2k¹		0	--	--	--	--
rs13152798^1,2	H	--	74726201(+)	`GGGTTC/TTGGCC`	1	--	us2k¹		4		NS EA	402
rs13128111^1,2	H	--	74726217(+)	`AGATTA/CCCaaa`	1	--	us2k¹		4		NS EA	406
rs58287114^1,2	C	--	74726264(+)	`AAAAA-/AAAAAAAAAAAAAAA/AA AAAAAAAAAAAAAAAAAAAAGAAAA`	2	--	us2k¹ cds¹		1		NA	2
rs144025891^1,2		--	74726275(+)	`AAAAG-/AAAAGA`	1	--	us2k¹		0	--	--	--	--
rs3756074^1,2	C,F,H	--	74726403(+)	`TTTTTG/CTGTTG`	1	--	us2k¹		14		NA NS EA WA	1334

HapMap Linkage Disequilibrium report for PF4 (74846794 - 74847841 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for PF4: About this table

Variant ID	Type	Subtype	PubMed ID
nsv525980	CNV	Gain	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PF4

DNA2.0 Custom Variant and Variant Library Synthesis for PF4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 173460 OMIM disorders: --

13 diseases for PF4:
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tuberculosis acute poststreptococcal glomerulonephritis erythromelalgia intermediate coronary syndrome

malaria myocardial infarction polycythemia vera protein s deficiency

iga glomerulonephritis sneddon syndrome learning disability hemophilia b

atherosclerosis

4 inferred disease relationships from the University of Copenhagen DISEASES database for PF4:

Thrombocytopenia Vascular disease Heart disease Myeloma

Find genes that share disorders with PF4 About GenesLikeMe

Selected Novoseek inferred disease relationships for PF4 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombocytopenia	85.4	191	8282825 (3), 12753876 (3), 17495129 (3), 10938877 (2) (see all 99)
thrombosis	75.6	75	14764524 (3), 20004006 (3), 9002937 (3), 8282825 (2) (see all 38)
abnormal platelets	61.3	2	2141791 (1), 1931099 (1)
thromboembolism	60.5	6	11827497 (1), 11442479 (1), 19521017 (1)
megakaryoblastic leukemia acute	60.5	2	1337850 (1), 1493450 (1)
thrombocytosis	59.9	10	2140694 (2), 1826402 (1), 10086090 (1), 16462666 (1) (see all 6)
thrombophilia	58.4	2	11342462 (1), 16766786 (1)
thrombocythemia essential	51.3	4	1386487 (1), 16138352 (1), 15352995 (1), 16977569 (1)
platelet aggregation, spontaneous	48.8	3	1692679 (1), 8870174 (1)
erythromelalgia	46.9	5	16138352 (2), 12781799 (1), 8883266 (1)

Genetic Association Database (GAD): PF4
Human Genome Epidemiology (HuGE) Navigator: PF4 (10 documents)

Export disorders for PF4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PF4 gene, integrated from 10 sources (see all 919):
(articles sorted by number of sources associating them with PF4)

Utopia: connect your pdf to the dynamic
world of online information

Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)^{1, 2, 9} Eisman R.... Poncz M. (Blood 1990)
Localization of distal regulatory domains in the megakaryocyte- specific platelet basic protein/platelet factor 4 gene locus. (PubMed id 11468158)^{1, 2, 9} Zhang C.... Reilly M.P. (Blood 2001)
NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N- terminal chimera: a symmetric tetramer. (PubMed id 7547867)^{1, 2, 9} Mayo K.H.... Daly T.J. (Biochemistry 1995)
Crystal structure of recombinant human platelet factor 4. (PubMed id 8031770)^{1, 2, 9} Zhang X.... Maione T.E. (Biochemistry 1994)
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (J. Infect. Dis. 2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5196	HGNC: 8861	AceView: PF4	Ensembl:ENSG00000163737	euGenes: HUgn5196
ECgene: PF4	Kegg: 5196	H-InvDB: PF4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PF4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PF4	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CXCL4

Intellectual Property for PF4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PF4 gene:
Search GeneIP for patents involving PF4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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Platelet Factor 4

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Leg Ulcer
Intermittent Claudication
ABNORMAL PLATELETS
Myelofibrosis
Hemorrhagic diseases
Raynauds Phenomenon
essential hypertension
Peripheral Vascular Diseases
Erythroleukemia
Acute myocardial infarction
Dermatitis Atopic
Megakaryoblastic Leukemia Acute
Myocardial Ischemia
Ischemia
Atherosclerosis
Neovascularization
PLATELET AGGREGATION, SPONTANEOUS
Antiphospholipid Syndrome
Adenocarcinoma
IDIOPATHIC CARDIOMYOPATHY
CONGENITAL HEART DISEASE
cell damage
disability
Allergic rhinitis
Cancer
Hemolysis
Diabetes Mellitus Insulin-Dependent
Thrombocytopenia
Coronary Atherosclerosis
Erythromelalgia
SKIN NECROSIS
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Cerebral Infarction
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Colorectal Cancer
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APC Resistance
Melanoma
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HYPERTENSION ARTERIAL
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Purpura Thrombocytopenic
Hyperplasia
Venous Thrombosis
clinical depression
atherosclerotic plaque
Atrial Fibrillation
Carcinoma
Infarction Lacunar
Leukemia
Diabetes Mellitus
Blast Crisis
VENOUS OCCLUSION
Tension-Type Headache
Myocardial Infarction
Uremia
Coronary Artery Disease
Polycythemia Vera
Ascites
Mitral stenosis
Bleeding
Glanzmann Thrombasthenia
Blood Loss Postoperative
STROKE
Thrombophilia
PROLONGED BLEEDING TIME
Chromosomal Aberrations
Arteriosclerosis Obliterans
Pulmonary Embolism
Thrombocythemia Essential
Cholera
platelet dysfunction
Sclerosis Systemic
Renal Failure Chronic
Thromboembolism

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PF4 Gene

Platelet Factor 4

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