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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PF4 Gene

protein-coding GIFtS: 63
GCID: GC04M074836

Platelet Factor 4

(Previous name: platelet factor 4)

Microbiology & Infectious Diseases Congress

123 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Platelet Factor 4¹ ²		C-X-C Motif Chemokine 4² ³
Chemokine (C-X-C Motif) Ligand 4¹ ²		iroplact²
CXCL4² ³		oncostatin-A²
PF-4² ³		Iroplact³
SCYB4² ³		Oncostatin-A³

External Ids:	HGNC: 8861¹	Entrez Gene: 5196²	Ensembl: ENSG00000163737⁷	OMIM: 173460⁵	UniProtKB: P02776³

Export aliases for PF4 gene to outside databases

Previous GC identifers: GC04M075086 GC04M075247 GC04M075313 GC04M075211 GC04M070658

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PF4 Gene:

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of

activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet

aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of

hematopoiesis, angiogenesis and T-cell function. (provided by RefSeq, Mar 2012)

GeneCards Summary for PF4 Gene:

PF4 (platelet factor 4) is a protein-coding gene. Diseases associated with PF4 include erythromelalgia, and intermediate coronary syndrome, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776

Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds

more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for

neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor

than the longer form

Gene Wiki entry for PF4 (Platelet factor 4) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NT_022778.16 NC_018915.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PF4 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PF4 promoter sequence

Search SABiosciences Chromatin IP Primers for PF4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PF4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q12-q21

PF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PF4 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M074836: view genomic region (about GC identifiers)

Start:	74,846,794 bp from pter	End:	74,847,841 bp from pter
Size:	1,048 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776 (See protein sequence)

Recommended Name: Platelet factor 4 precursor

Size: 101 amino acids; 10845 Da

Subunit: Homotetramer

Subcellular location: Secreted

Mass spectrometry: Mass=7765; Method=Electrospray; Range=32-101; Source=PubMed:7644496;

Mass spectrometry: Mass=6033; Method=Electrospray; Range=48-101; Note=Short form; Source=PubMed:7644496;

6/7 PDB 3D structures from and Proteopedia for PF4 (see all 7):

1DN3 (3D)

1F9Q (3D)

1F9R (3D)

1F9S (3D)

1PFM (3D)

1PFN (3D)

Secondary accessions: Q53X61 Q9UC64 Q9UC65

Explore the universe of human proteins at neXtProt for PF4: NX_P02776

Explore proteomics data for PF4 at MOPED

PF4 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_002610.1

ENSEMBL proteins:

ENSP00000296029

Reactome Protein details: P02776
Human Recombinant Protein Products for PF4:

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	Novus Biologicals PF4 Proteins Novus Biologicals PF4 Lysates
	Sino Biological Recombinant Protein for PF4 Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for PF4
	Cloud-Clone Corp. Proteins for PF4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0031093	platelet alpha granule lumen	TAS	--

PF4 for ontologies About GeneDecksing

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Assay Products for PF4:

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	GenScript Custom Assay Services for PF4
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for PF4 Cloud-Clone Corp. CLIAs for PF4

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro protein domains:

IPR027222 PF4

IPR001811 Chemokine_IL8-like_dom

IPR001089 Chemokine_CXC

IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P02776

ProtoNet protein and cluster: P02776

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

PF4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PLF4_HUMAN, P02776

Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds

more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for

neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor

than the longer form

Genatlas biochemistry entry for PF4:

platelet factor 4 (see IMC2@)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	TAS	12466273
GO:0008201	heparin binding	IDA	9531587

PF4 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pf4):

hematopoietic system

homeostasis/metabolism

PF4 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Pf4^tm1Mako for PF4

inGenious Targeting Laboratory - Custom generated mouse model solutions for PF4

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PF4

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PF4

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PF4

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PF4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PF4
		SwitchGear 3'UTR luciferase reporter plasmid: PF4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PF4
		Search LifeMap BioReagents cell lines for PF4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PF4 About (see all 12)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Mediated Glucocorticoid Regulation	0.94	IL-6 Pathway	0.61
MIF Regulation of Innate Immune Cells	0.94	STAT3 Pathway	0.47
PEDF Induced Signaling	0.73	Endothelin-1 Signaling Pathway	0.46
all-trans-Retinoic Acid Signaling in Brain	0.71	Cytokine-cytokine receptor interaction	0.43

Chemokine Signaling

Chemokine Signaling

0.33

Chemokine signaling pathway

0.33

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			G alpha (i) signalling events	0.46

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.55
	GPCR downstream signaling	0.90

Rho Family GTPases

	Rho Family GTPases	0.61			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathways by source See SuperPaths
Show all pathways

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PF4 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

1 BioSystems Pathway for PF4

CXCR3-mediated signaling events

5/12 Reactome Pathways for PF4 (see all 12)

	GPCR downstream signaling
	Hemostasis
	Peptide ligand-binding receptors
	Signaling by GPCR
	GPCR ligand binding

2 Kegg Pathways (Kegg details for PF4):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

PF4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/71 Interacting proteins for PF4 (P02776^{2, 3} ENSP00000296029⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 71)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL8	P10145³, ENSP00000306512⁴	I2D: score=3 STRING: ENSP00000306512
PROC	P04070³, ENSP00000234071⁴	I2D: score=2 STRING: ENSP00000234071
SRGN	P10124³, ENSP00000242465⁴	I2D: score=2 STRING: ENSP00000242465
CXCL12	P48061³, ENSP00000363548⁴	I2D: score=1 STRING: ENSP00000363548
CCL5	P13501³, ENSP00000293272⁴	I2D: score=2 STRING: ENSP00000293272

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0006955	immune response	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0010628	positive regulation of gene expression	IDA	10666185
GO:0010744	positive regulation of macrophage derived foam cell differentiation	IDA	17244792

PF4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PF4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PF4 (PLF4)

1 DrugBank Compound for PF4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Drotrecogin alfa	Anticoagulant protein C (see all 4)	60202-16-6	target	--	11259926

10/114 Novoseek inferred chemical compound relationships for PF4 gene (see all 114) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparin	87.7	940	8282825 (7), 17257993 (6), 8857955 (6), 1537108 (6) (see all 99)
danaparoid	84.1	2	18983520 (1), 16109780 (1)
hirudin	80.3	7	16404704 (1), 9024148 (1), 18541684 (1), 1832654 (1) (see all 5)
fibrinopeptide a	75.6	11	7646626 (2), 7539015 (2), 7637955 (1), 1720884 (1) (see all 6)
txb2	75.1	95	8329704 (5), 1840363 (3), 10475099 (3), 15613179 (2) (see all 46)
fondaparinux	72.6	12	18262226 (3), 9518042 (1), 15317404 (1), 16359523 (1) (see all 10)
rantes	68.4	87	15459010 (9), 15899984 (5), 19201759 (3), 7531729 (3) (see all 38)
fibrinogen	67.9	72	17351162 (3), 8996302 (2), 11077138 (2), 7553675 (2) (see all 50)
tecogalan sodium	65.4	2	9409948 (1), 10439927 (1)
adp	65.1	49	7843648 (3), 12889011 (3), 9863147 (2), 11782701 (2) (see all 30)

Search CenterWatch for drugs/clinical trials and news about PF4 / PLF4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PF4 gene:

NM_002619.3

Unigene Cluster for PF4:

Platelet factor 4

Hs.81564 [show with all ESTs]

Unigene Representative Sequence: NM_002619

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000296029(uc003hhi.2)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PF4
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PF4

Additional mRNA sequence:

BC093965.1 BC112093.1 CR407677.1 M25897.1

2 DOTS entries:

DT.113152 DT.121223983

24/30 AceView cDNA sequences (see all 30):

CR407677 AI078445 BQ023965 BX114245 AI739539 AJ705588 NM_002619 T28407

T84282 N92470 M25897 AA152486 AA024823 AI185569 BV177626 CA426108

AA024929 AI766542 T85166 W17158 AI400188 AA152485 AI470327 R83715

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PF4 expression in normal human tissues (normalized intensities) PF4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

PF4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/10 selected tissues (see all 10) fully expand


Neural Crest (Gastrulation Derivatives) fully expand to see all 2 entries
Cranial Neural Crest Cells Branchial Arch 1
mesenchyme

Bone (Muscoskeletal System) fully expand to see all 2 entries
Mesenchymal Condensate Cells Zeugopod
Bone Marrow

Blood (Hematopoietic System) fully expand to see all 2 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow

Brain (Nervous System) fully expand to see all 2 entries
Medulla Oblongata

Mesoderm (Gastrulation Derivatives)
mesenchyme

See PF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PF4

SOURCE GeneReport for Unigene cluster: Hs.81564

SABiosciences Expression via Pathway-Focused PCR Arrays including PF4 (see all 8):

Endothelial Cell Biology in human mouse rat

Angiogenic Growth Factors in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Cytokines & Chemokines in human mouse rat

Angiogenesis in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PF4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PF4 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pf4^{1 , 5}	platelet factor 4^{1, 5}	75.91(n)¹ 72.28(a)¹		5 (44.78 cM)⁵ 56744¹ NM_019932.4¹ NP_064316.1¹ 90772435⁵
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	29(a)	possible ortholog	4(50379773-50381069)
lizard (Anolis carolinensis)	Reptilia	--	--	30(a)	possible ortholog	6(60123888-60134622)

ENSEMBL Gene Tree for PF4 (if available)
TreeFam Gene Tree for PF4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PF4 gene

PPBP² CXCL1² PF4V1² CXCL6² CXCL3² CXCL5² CXCL2² IL8²

9 SIMAP similar genes for PF4 using alignment to 1 protein entry: PLF4_HUMAN:

PF4V1 PPBP CXCL5 CXCL10 CXCL6 CXCL1

CXCL2 IL8 CXCL3

PF4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147843417^1,2		--	74724385(+)	`CCAACA/GTATTC`	1	--	ds500¹		0	--	--	--	--
rs111665740^1,2	C,F	--	74724455(+)	`GAGATG/ATGACA`	1	--	ds500¹		1		CSA	2
rs183996563^1,2		--	74724474(+)	`AGAGGC/TTGGAG`	1	--	ds500¹		0	--	--	--	--
rs188770400^1,2		--	74724524(+)	`AGAACA/GTAGAT`	1	--	ds500¹		0	--	--	--	--
rs150287185^1,2		--	74724631(+)	`CCCACC/TTGGGA`	1	--	ds500¹		0	--	--	--	--
rs112444347^1,2	C	--	74724797(+)	`AAAAA-/CATCATCA`	1	--	cds¹		1		CSA	2
rs352004^1,2	C,F,O,H	--	74724908(-)	`TATTAC/TCTTTG`	1	--	ut3¹		26		MN NS EA NA WA CSA	2514
rs144889653^1,2		--	74724938(+)	`TGTAGA/CTATAA`	1	--	ut3¹		0	--	--	--	--
rs352005^1,2	C,F,O,H	--	74724966(-)	`ATTCAT/CGCATT`	1	--	ut3¹		14		MN NA NS EA WA	912
rs11574452^1,2	C,F,H	--	74724999(-)	`GTTATG/TCTTGG`	1	--	ut3¹		19		NA NS EA	2466
rs11574451^1,2	H	--	74725120(-)	`GTATAG/CTCAAA`	1	--	ut3¹		5		NA NS EA	460
rs180789835^1,2	C	--	74725177(+)	`AATATC/GAGAAG`	1	--	ut3¹		0	--	--	--	--
rs352006^1,2	C,F,O,A,H	--	74725215(-)	`TACTTC/TTTTTT`	1	--	ut3¹ ese³ trp³		19		EA NA NS WA CSA EU	2165
rs201608869^1,2		--	74725244(+)	`CACACA/GTAGGC`	1	--	ut3¹		0	--	--	--	--
rs200691269^1,2		--	74725266(+)	`AACTCC/TCCAAA`	2	E G	mis¹		0	--	--	--	--
rs199976537^1,2		--	74725313(+)	`AGGTCC/TAAGCA`	2	L	syn¹		0	--	--	--	--
rs201899718^1,2	C	--	74725315(+)	`GTCCAA/C/GGCAAA`	3	L V	syn¹ mis¹		0	--	--	--	--
rs114655702^1,2		--	74725317(+)	`CCAAGC/AAAATT`	2	/C /F	mis¹		1		NA	214
rs116188786^1,2		--	74725328(+)	`TTCCTT/CCCATT`	2	/G	syn¹		1		WA	216
rs117806951^1,2	C	--	74725442(+)	`GCGGGA/GGCACT`	1	--	int¹		1		EA	120
rs11574450^1,2	C,F,H	--	74725449(-)	`ATCTGT/GCAGTG`	1	--	int¹		8		NA NS EA EU	2002
rs2233648^1,2	C,F	--	74725474(-)	`CAACTG/CATGTG`	2	/L	syn¹		4		NS WA NA	5040
rs352007^1,2	C,F,A,H	--	74725630(+)	`GAGGAC/GGAGGG`	1	--	int¹ trp³		18		EA NA MN NS WA CSA EU	1171
rs116796864^1,2	C,F	--	74725936(+)	`GACCAC/TAAGTG`	2	M V	mis¹		1		EA	166
rs190601797^1,2		--	74726009(+)	`CTCATC/GCTGCG`	1	--	ut5¹		0	--	--	--	--
rs143069856^1,2		--	74726085(+)	`AATGAC/TTCCTG`	1	--	ut5¹		0	--	--	--	--
rs116253707^1,2	F	--	74726103(+)	`CCGGCA/TCGTTT`	1	--	ut5¹		1		WA	118
rs182327392^1,2		--	74726128(+)	`CTTCCA/GGTCCG`	1	--	ut5¹		0	--	--	--	--
rs13128069^1,2	H	--	74726150(+)	`TGGACA/CCCGAG`	1	--	ut5¹		4		NS EA	420
rs13151226^1,2	H	--	74726177(+)	`ACTAAG/AATAGT`	1	--	ut5¹		4		NS EA	418
rs13152788^1,2	H	--	74726184(+)	`TAGTAC/TTGGGA`	1	--	us2k¹		4		NS EA	418
rs13151248^1,2	H	--	74726191(+)	`GGGAAG/AACTTG`	1	--	us2k¹		4		NS EA	418
rs187412522^1,2		--	74726193(+)	`GAAGAC/TTTGGG`	1	--	us2k¹		0	--	--	--	--
rs13152798^1,2	H	--	74726201(+)	`GGGTTC/TTGGCC`	1	--	us2k¹		4		NS EA	402
rs13128111^1,2	H	--	74726217(+)	`AGATTA/CCCaaa`	1	--	us2k¹		4		NS EA	406
rs58287114^1,2	C	--	74726264(+)	`AAAAA-/AAAAAAAAAAAAAAA/AA AAAAAAAAAAAAAAAAAAAAGAAAA`	2	--	us2k¹ cds¹		1		NA	2
rs144025891^1,2		--	74726275(+)	`AAAAG-/AAAAGA`	1	--	us2k¹		0	--	--	--	--
rs3756074^1,2	C,F,H	--	74726403(+)	`TTTTTG/CTGTTG`	1	--	us2k¹		14		NA NS EA WA	1334

HapMap Linkage Disequilibrium report for PF4 (74846794 - 74847841 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for PF4: About this table

Variant ID	Type	Subtype	PubMed ID
nsv525980	CNV	Gain	19592680

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PF4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 173460 OMIM disorders: --

20/123 diseases for PF4 (see all 123): About MalaCards

erythromelalgia intermediate coronary syndrome sneddon syndrome acute poststreptococcal glomerulonephritis

heparin-induced thrombocytopenia essential thrombocythemia megakaryocytic leukemia arteriosclerosis obliterans

iga glomerulonephritis intermittent claudication polycythemia vera arteriosclerosis

uremia corneal neovascularization thrombasthenia glanzmann's thrombasthenia

polycythemia cerebral infarction headache peripheral vascular disease

4 diseases from the University of Copenhagen DISEASES database for PF4:

Thrombocytopenia Vascular disease Heart disease Myeloma

PF4 for disorders About GeneDecksing

10/94 Novoseek inferred disease relationships for PF4 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombocytopenia	85.4	191	8282825 (3), 12753876 (3), 17495129 (3), 10938877 (2) (see all 99)
thrombosis	75.6	75	14764524 (3), 20004006 (3), 9002937 (3), 8282825 (2) (see all 38)
abnormal platelets	61.3	2	2141791 (1), 1931099 (1)
thromboembolism	60.5	6	11827497 (1), 11442479 (1), 19521017 (1)
megakaryoblastic leukemia acute	60.5	2	1337850 (1), 1493450 (1)
thrombocytosis	59.9	10	2140694 (2), 1826402 (1), 10086090 (1), 16462666 (1) (see all 6)
thrombophilia	58.4	2	11342462 (1), 16766786 (1)
thrombocythemia essential	51.3	4	1386487 (1), 16138352 (1), 15352995 (1), 16977569 (1)
platelet aggregation, spontaneous	48.8	3	1692679 (1), 8870174 (1)
erythromelalgia	46.9	5	16138352 (2), 12781799 (1), 8883266 (1)

Genetic Association Database (GAD): PF4
Human Genome Epidemiology (HuGE) Navigator: PF4 (10 documents)

Export disorders for PF4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PF4 gene, integrated from 9 sources (see all 915):
(articles sorted by number of sources associating them with PF4)

Utopia: connect your pdf to the dynamic
world of online information

Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)^{1, 2, 9} Eisman R.... Poncz M. (1990)
Localization of distal regulatory domains in the megakaryocyte- specific platelet basic protein/platelet factor 4 gene locus. (PubMed id 11468158)^{1, 2, 9} Zhang C.... Reilly M.P. (2001)
NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. (PubMed id 7547867)^{1, 2, 9} Mayo K.H....Daly T.J. (1995)
Crystal structure of recombinant human platelet factor 4. (PubMed id 8031770)^{1, 2, 9} Zhang X.... Maione T.E. (1994)
Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (2009)
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5196	HGNC: 8861	AceView: PF4	Ensembl:ENSG00000163737	euGenes: HUgn5196
ECgene: PF4	Kegg: 5196	H-InvDB: PF4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PF4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PF4	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CXCL4

Intellectual Property for PF4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PF4 gene:
Search GeneIP for patents involving PF4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Leg Ulcer
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ABNORMAL PLATELETS
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PROLONGED BLEEDING TIME
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PF4 Gene

Platelet Factor 4

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