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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PF4 Gene

protein-coding   GIFtS: 62
GCID: GC04M074836

platelet factor 4

(Previous name: platelet factor 4 )
 Explore 137 diseases affiliated with
PF4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PF4    

Aliases
for PF4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Platelet Factor 41 2     Chemokine (C-X-C Motif) Ligand 42
CXCL41 2 3     Iroplact3
SCYB41 2 3     Oncostatin-A3
PF-42 3     Iroplact3
C-X-C Motif Chemokine 42 3     Oncostatin-A3

External Ids:    HGNC: 88611   Entrez Gene: 51962   Ensembl: ENSG000001637377   OMIM: 1734605   UniProtKB: P027763   

Export aliases for PF4 gene to outside databases

Previous GC identifers: GC04M075086 GC04M075247 GC04M075313 GC04M075211 GC04M070658


Summaries
for PF4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PF4:
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated
platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation.
This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis,
angiogenesis and T-cell function. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more
strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and
monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form

Gene Wiki entry for PF4 (Platelet factor 4)


Genomic Views
for PF4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PF4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q21

PF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PF4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074836:  view genomic region     (about GC identifiers)

Start:
 74,846,794 bp from pter      End:
 74,847,841 bp from pter
Size:
 1,048 bases      Orientation:
 minus strand

Proteins
for PF4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776 (See protein sequence)
Recommended Name: Platelet factor 4 precursor  
Size: 101 amino acids; 10845 Da
Subunit: Homotetramer
Subcellular location: Secreted
Mass spectrometry: Mass=7765; Method=Electrospray; Range=32-101; Source=PubMed:7644496;
Mass spectrometry: Mass=6033; Method=Electrospray; Range=48-101; Note=Short form; Source=PubMed:7644496;
6/7 PDB 3D structures from and Proteopedia for PF4 (see all 7):
1DN3 (3D)        1F9Q (3D)        1F9R (3D)        1F9S (3D)        1PFM (3D)        1PFN (3D)    
Secondary accessions: Q53X61 Q9UC64 Q9UC65

Explore the universe of human proteins at neXtProt for PF4: NX_P02776

Post-translational modifications:

  • Binds non-covalently to a proteoglycan molecule1
  • View neXtProt modification sites for NX_P02776

    • PF4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002610.1  
    ENSEMBL proteins: 
     ENSP00000296029  
    Reactome Protein details: P02776
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for PF4 (CXCL4/PF4)
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    Novus Biologicals PF4 Lysates
    Sino Biological Recombinant Protein for PF4
    ProSpec Recombinant Protein for PF4
    Uscn Proteins for PF4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0031093platelet alpha granule lumen TAS--


    PF4 for ontologies           About GeneDecksing



    PF4 Antibody Products: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PF4

    Protein Domains /
    Families
    for PF4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PF4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR027222 PF4
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P02776

    ProtoNet protein and cluster: P02776

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for PF4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
    Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more
    strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and
    monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form

         Genatlas biochemistry entry for PF4:
    platelet factor 4 (see IMC2@)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PF4
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    SwitchGear 3'UTR luciferase reporter plasmid: PF4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity TAS12466273
    GO:0008201heparin binding IDA9531587


    PF4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Pf4tm1Mako for PF4
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pf4):
     hematopoietic system  homeostasis/metabolism 

    PF4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PF4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    4Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    5Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PF4 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    1 BioSystems Pathway for PF4 
        CXCR3-mediated signaling events

    5/12        Reactome Pathways for PF4 (see all 12)
        GPCR downstream signaling
    Hemostasis
    Peptide ligand-binding receptors
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for PF4):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    PF4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    70/71 Interacting proteins for PF4 (P027762, 3 ENSP000002960294) via UniProtKB, MINT, STRING, and/or I2D (see all 71) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL8P101453, ENSP000003065124I2D: score=3 STRING: ENSP00000306512
    PROCP040703, ENSP000002340714I2D: score=2 STRING: ENSP00000234071
    SRGNP101243, ENSP000002424654I2D: score=2 STRING: ENSP00000242465
    CXCL12P480613, ENSP000003635484I2D: score=1 STRING: ENSP00000363548
    CCL5P135013, ENSP000002932724I2D: score=2 STRING: ENSP00000293272
    FGF2P090383, ENSP000002644984I2D: score=1 STRING: ENSP00000264498
    LDLRP011303, ENSP000002524444I2D: score=3 STRING: ENSP00000252444
    SDC2P347413, ENSP000003070464I2D: score=1 STRING: ENSP00000307046
    THBDP072043, ENSP000003663074I2D: score=3 STRING: ENSP00000366307
    PLEKP085673, ENSP000002343134I2D: score=1 STRING: ENSP00000234313
    VCANP136113, ENSP000002650774I2D: score=2 STRING: ENSP00000265077
    CXCR3P496823, ENSP000003627954I2D: score=3 STRING: ENSP00000362795
    DARCQ165703I2D: score=1 
    A2MENSP000003239294STRING: ENSP00000323929
    ALBENSP000002958974STRING: ENSP00000295897
    APPENSP000002849814STRING: ENSP00000284981
    CFDENSP000003321394STRING: ENSP00000332139
    CLUENSP000003151304STRING: ENSP00000315130
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL9ENSP000003549014STRING: ENSP00000354901
    EGFENSP000002651714STRING: ENSP00000265171
    F13A1ENSP000002648704STRING: ENSP00000264870
    F2ENSP000003085414STRING: ENSP00000308541
    F5ENSP000003567714STRING: ENSP00000356771
    F8ENSP000003533934STRING: ENSP00000353393
    FIGFENSP000002979044STRING: ENSP00000297904
    FN1ENSP000003468394STRING: ENSP00000346839
    GAS6ENSP000003318314STRING: ENSP00000331831
    KNG1ENSP000002650234STRING: ENSP00000265023
    MMRN1ENSP000002647904STRING: ENSP00000264790
    PLGENSP000003089384STRING: ENSP00000308938
    PPBPENSP000002960284STRING: ENSP00000296028
    SERPINA1ENSP000003480684STRING: ENSP00000348068
    SERPINE1ENSP000002230954STRING: ENSP00000223095
    SERPINF2ENSP000003218534STRING: ENSP00000321853
    SERPING1ENSP000002784074STRING: ENSP00000278407
    SPARCENSP000002310614STRING: ENSP00000231061
    TGFB1ENSP000002219304STRING: ENSP00000221930
    TGFB2ENSP000003558964STRING: ENSP00000355896
    TGFB3ENSP000002386824STRING: ENSP00000238682
    TIMP1ENSP000002183884STRING: ENSP00000218388
    VEGFCENSP000002801934STRING: ENSP00000280193
    ACTN1ENSP000003779414STRING: ENSP00000377941
    ACTN2ENSP000003555374STRING: ENSP00000355537
    ACTN4ENSP000002526994STRING: ENSP00000252699
    ALDOAENSP000003369274STRING: ENSP00000336927
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNAO1ENSP000002624934STRING: ENSP00000262493
    GNAZENSP000002489964STRING: ENSP00000248996
    GNG2ENSP000003344484STRING: ENSP00000334448
    MAP2K3ENSP000003450834STRING: ENSP00000345083
    MAP2K6ENSP000003519974STRING: ENSP00000351997
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR4ENSP000003326594STRING: ENSP00000332659
    CCR5ENSP000002923034STRING: ENSP00000292303
    CCR6ENSP000003393934STRING: ENSP00000339393
    CCR7ENSP000002466574STRING: ENSP00000246657
    CCR8ENSP000003264324STRING: ENSP00000326432
    CCR9ENSP000003502564STRING: ENSP00000350256
    CX3CR1ENSP000003821664STRING: ENSP00000382166
    CXCR1ENSP000002956834STRING: ENSP00000295683
    CXCR2ENSP000003196354STRING: ENSP00000319635
    CXCR4ENSP000003868844STRING: ENSP00000386884
    CXCR5ENSP000002921744STRING: ENSP00000292174
    CXCR6ENSP000003044144STRING: ENSP00000304414
    XCR1ENSP000003104054STRING: ENSP00000310405
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006955immune response IEA--
    GO:0007596blood coagulation TAS--
    GO:0010628positive regulation of gene expression IDA10666185
    GO:0010744positive regulation of macrophage derived foam cell differentiation IDA17244792


    PF4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PF4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PF4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PF4

    1 DrugBank Compound for PF4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Drotrecogin alfaAnticoagulant protein C (see all 4)60202-16-6target--11259926

    10/114 Novoseek chemical compound relationships for PF4 gene (see all 114)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 87.7 940 8282825 (7), 17257993 (6), 8857955 (6), 1537108 (6) (see all 99)
    danaparoid 84.1 2 18983520 (1), 16109780 (1)
    hirudin 80.3 7 16404704 (1), 9024148 (1), 18541684 (1), 1832654 (1) (see all 5)
    fibrinopeptide a 75.6 11 7646626 (2), 7539015 (2), 7637955 (1), 1720884 (1) (see all 6)
    txb2 75.1 95 8329704 (5), 1840363 (3), 10475099 (3), 15613179 (2) (see all 46)
    fondaparinux 72.6 12 18262226 (3), 9518042 (1), 15317404 (1), 16359523 (1) (see all 10)
    rantes 68.4 87 15459010 (9), 15899984 (5), 19201759 (3), 7531729 (3) (see all 38)
    fibrinogen 67.9 72 17351162 (3), 8996302 (2), 11077138 (2), 7553675 (2) (see all 50)
    tecogalan sodium 65.4 2 9409948 (1), 10439927 (1)
    adp 65.1 49 7843648 (3), 12889011 (3), 9863147 (2), 11782701 (2) (see all 30)

    Search CenterWatch for drugs/clinical trials and news about PF4 / PLF4 

    Transcripts
    for PF4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PF4 gene: 
    NM_002619.3  

    Unigene Cluster for PF4:

    Platelet factor 4
    Hs.81564  [show with all ESTs]
    Unigene Representative Sequence: NM_002619
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296029(uc003hhi.2)

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC093965.1 BC112093.1 CR407677.1 M25897.1 

    2 DOTS entries:

    DT.113152  DT.121223983 

    24/30 AceView cDNA sequences (see all 30):

    CR407677 AI078445 BQ023965 N92470 AA024823 NM_002619 AI739539 M25897 
    T28407 AJ705588 AI185569 AA152486 T84282 BX114245 AA024929 W17158 
    T85166 AI766542 BV177626 CA426108 AI400188 AA152485 AI470327 R83715 

    GeneLoc Exon Structure


    Expression
    for PF4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PF4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    BrainMedulla OblongataBrain
    BrainMeningesBrain
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PF4

    SOURCE GeneReport for Unigene cluster: Hs.81564
        SABiosciences Expression via Pathway-Focused PCR Arrays including PF4 (see all 8): 
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PF4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PF4 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 34(a)
    		 1 → many
    		 4(52472071-52473367)


    ENSEMBL Gene Tree for PF4 (if available)
    TreeFam Gene Tree for PF4 (if available) 

    Paralogs
    for PF4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PF4 gene
    CXCL32  CXCL52  PPBP2  CXCL12  PF4V12  IL82  CXCL22  CXCL62  
    9 SIMAP similar genes for PF4 using alignment to 1 protein entry:     PLF4_HUMAN:
    PF4V1    PPBP    CXCL5    CXCL10    CXCL6    CXCL1
    CXCL2    IL8    CXCL3

    PF4 for paralogs           About GeneDecksing



    Genomic Variants
    for PF4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PF4
    DNA2.0 Custom Variant and Variant Library Synthesis for PF4

    Disorders / Diseases
    for PF4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PF4 for disorders           About GeneDecksing

    OMIM gene information: 173460    OMIM disorders: --

    20/137 diseases for PF4 (see all 137):    About MalaCards
    disseminated intravascular coagulation    heparin-induced thrombocytopenia    spinal cord injury    glanzmann's thrombasthenia
    acute poststreptococcal glomerulonephritis    intermittent claudication    mitral valve prolapse    hematopoiesis
    arteriosclerosis obliterans    polycythemia vera    corneal neovascularization    von willebrand's disease
    pre-eclampsia    myocardial infarction    abdominal aortic aneurysm    atrial fibrillation
    acute myocardial infarction    peripheral vascular disease    pulmonary embolism    thrombasthenia

    3 diseases from the University of Copenhagen DISEASES database for PF4:
    Thrombocytopenia     Vascular disease     Heart disease

    10/94 Novoseek disease relationships for PF4 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombocytopenia 85.4 191 8282825 (3), 12753876 (3), 17495129 (3), 10938877 (2) (see all 99)
    thrombosis 75.6 75 14764524 (3), 20004006 (3), 9002937 (3), 8282825 (2) (see all 38)
    abnormal platelets 61.3 2 2141791 (1), 1931099 (1)
    thromboembolism 60.5 6 11827497 (1), 11442479 (1), 19521017 (1)
    megakaryoblastic leukemia acute 60.5 2 1337850 (1), 1493450 (1)
    thrombocytosis 59.9 10 2140694 (2), 1826402 (1), 10086090 (1), 16462666 (1) (see all 6)
    thrombophilia 58.4 2 11342462 (1), 16766786 (1)
    thrombocythemia essential 51.3 4 1386487 (1), 16138352 (1), 15352995 (1), 16977569 (1)
    platelet aggregation, spontaneous 48.8 3 1692679 (1), 8870174 (1)
    erythromelalgia 46.9 5 16138352 (2), 12781799 (1), 8883266 (1)

    Human Genome Epidemiology (HuGE) Navigator: PF4 (10 documents)

    Export disorders for PF4 gene to outside databases

    Publications
    for PF4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PF4 gene, integrated from 9 sources (see all 908):
    (articles sorted by number of sources associating them with PF4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)1, 2, 9 Eisman R.... Poncz M. (1990)
    2. Localization of distal regulatory domains in the megakaryocyte- specific platelet basic protein/platelet factor 4 gene locus. (PubMed id 11468158)1, 2, 9 Zhang C.... Reilly M.P. (2001)
    3. Crystal structure of recombinant human platelet factor 4. (PubMed id 8031770)1, 2, 9 Zhang X.... Maione T.E. (1994)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. (PubMed id 3098319)1, 2 Poncz M.... Schwartz E. (1987)
    7. Human platelet factor 4 gene is mapped to 4q12----q21. (PubMed id 3622011)1, 3 Griffin C.A....Poncz M. (1987)
    8. Complete covalent structure of human platelet factor 4. (PubMed id 6445090)1, 2 Morgan F.J.... Chesterman C.N. (1980)
    9. Isolation, crystallization, and primary amino acid sequence of human platelet factor 4. (PubMed id 893407)1, 2 Hermodson M.... Kurachi K. (1977)
    10. Primary structure of human platelet factor 4. (PubMed id 601757)1, 2 Walz D.A.... McCoy L.E. (1977)

    External Searches for PF4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PF4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5196 HGNC: 8861 AceView: PF4 Ensembl:ENSG00000163737 euGenes: HUgn5196
    ECgene: PF4 Kegg: 5196 H-InvDB: PF4

    Other Databases showing PF4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PF4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PF4 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL4

    Intellectual Property
    for PF4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PF4 gene:
    Search GeneIP for patents involving PF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    Advanced Cell Diagnostics
    About This Section

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