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PF4 Gene

protein-coding   GIFtS: 62
GCID: GC04M074836

Platelet Factor 4

(Previous name: platelet factor 4)
  See PF4-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Platelet Factor 41 2     C-X-C Motif Chemokine 42 3
Chemokine (C-X-C Motif) Ligand 41 2     iroplact2
CXCL42 3     oncostatin-A2
PF-42 3     Iroplact3
SCYB42 3     Oncostatin-A3

External Ids:    HGNC: 88611   Entrez Gene: 51962   Ensembl: ENSG000001637377   OMIM: 1734605   UniProtKB: P027763   

Export aliases for PF4 gene to outside databases

Previous GC identifiers: GC04M075086 GC04M075247 GC04M075313 GC04M075211 GC04M070658

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PF4 Gene:
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of
activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet
aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of
hematopoiesis, angiogenesis and T-cell function. (provided by RefSeq, Mar 2012)

GeneCards Summary for PF4 Gene:
PF4 (platelet factor 4) is a protein-coding gene. Diseases associated with PF4 include tuberculosis, and acute poststreptococcal glomerulonephritis. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds
more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for
neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor
than the longer form

Gene Wiki entry for PF4 (Platelet factor 4) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PF4 gene promoter:
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPF4 promoter sequence
   Search Chromatin IP Primers for PF4

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PF4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q21

PF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PF4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074836:  view genomic region     (about GC identifiers)

74,846,794 bp from pter      End:
74,847,841 bp from pter
1,048 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776 (See protein sequence)
Recommended Name: Platelet factor 4 precursor  
Size: 101 amino acids; 10845 Da
Subunit: Homotetramer
Mass spectrometry: Mass=7765; Method=Electrospray; Range=32-101; Source=PubMed:7644496;
Mass spectrometry: Mass=6033; Method=Electrospray; Range=48-101; Note=Short form; Source=PubMed:7644496;
Selected PDB 3D structures from and Proteopedia for PF4 (see all 7):
1DN3 (3D)        1F9Q (3D)        1F9R (3D)        1F9S (3D)        1PFM (3D)        1PFN (3D)    
Secondary accessions: Q53X61 Q9UC64 Q9UC65

Explore the universe of human proteins at neXtProt for PF4: NX_P02776

Explore proteomics data for PF4 at MOPED

See PF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002610.1  
ENSEMBL proteins: 
Reactome Protein details: P02776

PF4 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for PF4 (CXCL4/PF4)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for PF4
OriGene Protein Over-expression Lysate for PF4
OriGene MassSpec for PF4
OriGene Custom Protein Services for PF4
GenScript Purified and Recombinant Proteins for PF4
Novus Biologicals PF4 Proteins
Novus Biologicals PF4 Lysates
Sino Biological Recombinant Protein for PF4
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for PF4
Cloud-Clone Corp. Proteins for PF4

Search eBioscience for Proteins for PF4 

antibodies-online proteins for PF4 (85 products) 

Search antibodies-online for peptides for PF4

GeneTex Proteins for PF4: (see all 2
                    CXCL4 Recombinant Protein (Active) (GTX48162-PRO)

PF4 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for PF4 (CXCL4/PF4)
OriGene Antibodies for PF4
OriGene Custom Antibody Services for PF4
Novus Biologicals PF4 Antibodies
Abcam antibodies for PF4
Cloud-Clone Corp. Antibodies for PF4
ThermoFisher Antibodies for PF4
antibodies-online antibodies for PF4 (70 products) 

GeneTex Antibodies for PF4:  
                    PF4 Antibodies

PF4 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for PF4
R&D Systems ELISAs for PF4 (CXCL4/PF4)         (see all)
GenScript Custom Assay Services for PF4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for PF4
Cloud-Clone Corp. CLIAs for PF4
Search eBioscience for ELISAs for PF4 
antibodies-online kits for PF4 (54 products) 

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

4 InterPro protein domains:
 IPR027222 PF4
 IPR001811 Chemokine_IL8-like_dom
 IPR001089 Chemokine_CXC
 IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P02776

ProtoNet protein and cluster: P02776

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
Similarity: Belongs to the intercrine alpha (chemokine CxC) family

Find genes that share domains with PF4           About GenesLikeMe

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PLF4_HUMAN, P02776
Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds
more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for
neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor
than the longer form

     Genatlas biochemistry entry for PF4:
platelet factor 4 (see IMC2@)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity TAS12466273
GO:0008201heparin binding IDA9531587
GO:0048248CXCR3 chemokine receptor binding IDA12782716
Find genes that share ontologies with PF4           About GenesLikeMe

     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pf4):
 hematopoietic system  homeostasis/metabolism 

Find genes that share phenotypes with PF4           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Pf4tm1Mako for PF4

   genOway: Develop your customized and physiologically relevant rodent model for PF4

    Taconic Biosciences Mouse Models for PF4:  
                    TF2376 - Pf4

CRISPR Knockouts: 
   OriGene CRISPR knockouts for PF4

Block miRNA regulation of human, mouse, rat PF4 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate PF4
SwitchGear 3'UTR luciferase reporter plasmidPF4 3' UTR sequence
Inhib. RNA
OriGene RNAi products in human, mouse, rat for PF4
Predesigned siRNA for gene silencing in human, mouse, rat PF4

OriGene clones in human, mouse for PF4 (see all 6)
OriGene ORF clones in mouse, rat for PF4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PF4 (NM_002619)
Sino Biological Human cDNA Clone for PF4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PF4

Cell Line
GenScript Custom overexpressing Cell Line Services for PF4
Browse ESI BIO Cell Lines and PureStem Progenitors for PF4 
In Situ Assay

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot
PLF4_HUMAN, P02776: Secreted
Subcellular locations from COMPARTMENTS: 

plasma membrane1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0031093platelet alpha granule lumen TAS--

Find genes that share ontologies with PF4           About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for PF4 About   (see all 14)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
IL-6 Pathway0.61
MIF Mediated Glucocorticoid Regulation0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
3Chemokine Signaling
Chemokine Signaling0.33
Chemokine signaling pathway0.33
4Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44
5Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90

Find genes that share SuperPaths with PF4           About GenesLikeMe

Pathways by source                                   See SuperPaths
Show all pathways

1 R&D Systems Pathway for PF4
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PF4 (see all 17)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Transendothelial Migration of Leukocytes
MIF Mediated Glucocorticoid Regulation

1 BioSystems Pathway for PF4
    CXCR3-mediated signaling events

5 Reactome Pathways for PF4
    Platelet degranulation
Chemokine receptors bind chemokines
G alpha (i) signalling events
Cell surface interactions at the vascular wall
Common Pathway

2 Kegg Pathways  (Kegg details for PF4):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including PF4 (see all 8): 
          Endothelial Cell Biology in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Angiogenesis in human mouse rat


    GeneGlobe Interaction Network for PF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PF4 (P027762, 3 ENSP000002960294) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
InteractantInteraction Details
GeneCardExternal ID(s)
IL8P101453, ENSP000003065124I2D: score=3 STRING: ENSP00000306512
PROCP040703, ENSP000002340714I2D: score=2 STRING: ENSP00000234071
SRGNP101243, ENSP000002424654I2D: score=2 STRING: ENSP00000242465
CXCL12P480613, ENSP000003635484I2D: score=1 STRING: ENSP00000363548
CCL5P135013, ENSP000002932724I2D: score=2 STRING: ENSP00000293272
About this table

Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002576platelet degranulation TAS--
GO:0006955immune response IEA--
GO:0007596blood coagulation TAS--
GO:0010628positive regulation of gene expression IDA10666185
GO:0010744positive regulation of macrophage derived foam cell differentiation IDA17244792

Find genes that share ontologies with PF4           About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PF4 (PLF4)

1 DrugBank Compound for PF4    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Drotrecogin alfaAnticoagulant protein C (see all 4)60202-16-6target--11259926

Selected Novoseek inferred chemical compound relationships for PF4 gene (see all 114)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
heparin 87.7 940 8282825 (7), 17257993 (6), 8857955 (6), 1537108 (6) (see all 99)
danaparoid 84.1 2 18983520 (1), 16109780 (1)
hirudin 80.3 7 16404704 (1), 9024148 (1), 18541684 (1), 1832654 (1) (see all 5)
fibrinopeptide a 75.6 11 7646626 (2), 7539015 (2), 7637955 (1), 1720884 (1) (see all 6)
txb2 75.1 95 8329704 (5), 1840363 (3), 10475099 (3), 15613179 (2) (see all 46)
fondaparinux 72.6 12 18262226 (3), 9518042 (1), 15317404 (1), 16359523 (1) (see all 10)
rantes 68.4 87 15459010 (9), 15899984 (5), 19201759 (3), 7531729 (3) (see all 38)
fibrinogen 67.9 72 17351162 (3), 8996302 (2), 11077138 (2), 7553675 (2) (see all 50)
tecogalan sodium 65.4 2 9409948 (1), 10439927 (1)
adp 65.1 49 7843648 (3), 12889011 (3), 9863147 (2), 11782701 (2) (see all 30)

Find genes that share compounds with PF4           About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for PF4 gene (2 alternative transcripts): 
NM_002619.3  XM_005265696.1  

Unigene Cluster for PF4:

Platelet factor 4
Hs.81564  [show with all ESTs]
Unigene Representative Sequence: NM_002619
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
Block miRNA regulation of human, mouse, rat PF4 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate PF4
SwitchGear 3'UTR luciferase reporter plasmidPF4 3' UTR sequence
Inhib. RNA
OriGene RNAi products in human, mouse, rat for PF4
Predesigned siRNA for gene silencing in human, mouse, rat PF4
OriGene clones in human, mouse for PF4 (see all 6)
OriGene ORF clones in mouse, rat for PF4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PF4 (NM_002619)
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PF4
OriGene qPCR primer pairs and template standards for PF4
OriGene qSTAR qPCR primer pairs in human, mouse for PF4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PF4
  QuantiTect SYBR Green Assays in human, mouse, rat PF4
  QuantiFast Probe-based Assays in human, mouse, rat PF4

Additional mRNA sequence: 

BC093965.1 BC112093.1 CR407677.1 M25897.1 

2 DOTS entries:

DT.113152  DT.121223983 

Selected AceView cDNA sequences (see all 30):

AI078445 CR407677 BQ023965 N92470 AI739539 NM_002619 T28407 AJ705588 
AA024823 AA152486 BX114245 M25897 AI185569 T84282 W17158 AI766542 
CA426108 BV177626 AA024929 T85166 AI400188 AI470327 R83715 AA152485 

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
PF4 Expression
About this image

PF4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 10) fully expand
 Blood (Hematopoietic System)    fully expand to see all 3 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Mesenchymal Condensate Cells Zeugopod
         Bone Marrow
 Brain (Nervous System)    fully expand to see all 2 entries
         Medulla Oblongata
 Neural Crest (Gastrulation Derivatives)
         Cranial Neural Crest Cells Branchial Arch 1
 Cartilage (Muscoskeletal System)
         Mesenchymal Condensate Cells Zeugopod
PF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PF4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.81564
    Pathway & Disease-focused RT2 Profiler PCR Arrays including PF4 (see all 8): 
          Endothelial Cell Biology in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Angiogenesis in human mouse rat

OriGene qPCR primer pairs and template standards for PF4
OriGene qSTAR qPCR primer pairs in human, mouse for PF4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PF4
QuantiTect SYBR Green Assays in human, mouse, rat PF4
QuantiFast Probe-based Assays in human, mouse, rat PF4
In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PF4 gene from Selected species (see all 8)    About this table
Organism Taxonomic
Gene Description Human
(Mus musculus)
Mammalia Pf41 , 5 platelet factor 41, 5 79.22(n)1
  5 (44.78 cM)5
567441  NM_019932.41  NP_064316.11 
(Gallus gallus)
Aves --
Uncharacterized protein
1 → many
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
1 → many

ENSEMBL Gene Tree for PF4 (if available)
TreeFam Gene Tree for PF4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for PF4 gene
PPBP2  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
9 SIMAP similar genes for PF4 using alignment to 1 protein entry:     PLF4_HUMAN:
PF4V1    PPBP    CXCL5    CXCL10    CXCL6    CXCL1
CXCL2    IL8    CXCL3

Find genes that share paralogs with PF4           About GenesLikeMe

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for PF4 (see all 121)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
Chr 4 posSequence#AA
--74724385(+) CCAACA/GTATTC 1 -- ds50010--------
C,F--74724455(+) GAGATG/ATGACA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
--74724474(+) AGAGGC/TTGGAG 1 -- ds50010--------
--74724524(+) AGAACA/GTAGAT 1 -- ds50010--------
--74724631(+) CCCACC/TTGGGA 1 -- ds50010--------
C--74724797(+) AAAAA-/CATCATCA 1 -- cds11Minor allele frequency- CAT:0.50CSA 2
C,F,O,H--74724908(-) TATTAC/TCTTTG 1 -- ut3126Minor allele frequency- T:0.12MN NS EA NA WA CSA 2514
--74724938(+) TGTAGA/CTATAA 1 -- ut310--------
C,F,O,H--74724966(-) ATTCAT/CGCATT 1 -- ut3114Minor allele frequency- C:0.09MN NA NS EA WA 912
C,F,H--74724999(-) GTTATG/TCTTGG 1 -- ut3119Minor allele frequency- T:0.07NA NS EA 2466

HapMap Linkage Disequilibrium report for PF4 (74846794 - 74847841 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PF4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv525980CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PF4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 173460    OMIM disorders: --

13 diseases for PF4:    
About MalaCards
tuberculosis    acute poststreptococcal glomerulonephritis    erythromelalgia    intermediate coronary syndrome
malaria    myocardial infarction    polycythemia vera    protein s deficiency
iga glomerulonephritis    sneddon syndrome    learning disability    hemophilia b

4 inferred disease relationships from the University of Copenhagen DISEASES database for PF4:
Thrombocytopenia     Vascular disease     Heart disease     Myeloma

Find genes that share disorders with PF4           About GenesLikeMe

Selected Novoseek inferred disease relationships for PF4 gene (see all 94)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thrombocytopenia 85.4 191 8282825 (3), 12753876 (3), 17495129 (3), 10938877 (2) (see all 99)
thrombosis 75.6 75 14764524 (3), 20004006 (3), 9002937 (3), 8282825 (2) (see all 38)
abnormal platelets 61.3 2 2141791 (1), 1931099 (1)
thromboembolism 60.5 6 11827497 (1), 11442479 (1), 19521017 (1)
megakaryoblastic leukemia acute 60.5 2 1337850 (1), 1493450 (1)
thrombocytosis 59.9 10 2140694 (2), 1826402 (1), 10086090 (1), 16462666 (1) (see all 6)
thrombophilia 58.4 2 11342462 (1), 16766786 (1)
thrombocythemia essential 51.3 4 1386487 (1), 16138352 (1), 15352995 (1), 16977569 (1)
platelet aggregation, spontaneous 48.8 3 1692679 (1), 8870174 (1)
erythromelalgia 46.9 5 16138352 (2), 12781799 (1), 8883266 (1)

Genetic Association Database (GAD): PF4
Human Genome Epidemiology (HuGE) Navigator: PF4 (10 documents)

Export disorders for PF4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PF4 gene, integrated from 10 sources (see all 919) (see top 10):
(articles sorted by number of sources associating them with PF4)

  1. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)1, 2, 9 Eisman R.... Poncz M. (Blood 1990)
  2. Localization of distal regulatory domains in the megakaryocyte- specific platelet basic protein/platelet factor 4 gene locus. (PubMed id 11468158)1, 2, 9 Zhang C.... Reilly M.P. (Blood 2001)
  3. NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N- terminal chimera: a symmetric tetramer. (PubMed id 7547867)1, 2, 9 Mayo K.H.... Daly T.J. (Biochemistry 1995)
  4. Crystal structure of recombinant human platelet factor 4. (PubMed id 8031770)1, 2, 9 Zhang X.... Maione T.E. (Biochemistry 1994)
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
  9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  11. Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. (PubMed id 3098319)1, 2 Poncz M.... Schwartz E. (Blood 1987)
  12. Human platelet factor 4 gene is mapped to 4q12----q21. (PubMed id 3622011)1, 3 Griffin C.A....Poncz M. (Cytogenet. Cell Genet. 1987)
  13. Complete covalent structure of human platelet factor 4. (PubMed id 6445090)1, 2 Morgan F.J.... Chesterman C.N. (Thromb. Haemost. 1980)
  14. Isolation, crystallization, and primary amino acid sequence of human platelet factor 4. (PubMed id 893407)1, 2 Hermodson M.... Kurachi K. (J. Biol. Chem. 1977)
  15. Primary structure of human platelet factor 4. (PubMed id 601757)1, 2 Walz D.A.... McCoy L.E. (Thromb. Res. 1977)
  16. Amino acid sequence of human platelet factor 4. (PubMed id 267922)1, 2 Deuel T.F.... Heinrikson R.L. (Proc. Natl. Acad. Sci. U.S.A. 1977)
  17. Negative regulation of human megakaryocytopoiesis by human platelet factor 4 and beta thromboglobulin: comparative analysis in bone marrow cultures from normal individuals and patients with essential thrombocythaemia and immune thrombocytopenic purpura. (PubMed id 2140694)1, 9 Han Z.C....Caen J.P. (Br. J. Haematol. 1990)
  18. Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C. (PubMed id 9395524)1, 9 Dudek A.Z....Slungaard A. (J. Biol. Chem. 1997)
  19. Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. (PubMed id 15459010)1, 9 von Hundelshausen P....Weber C. (Blood 2005)
  20. Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis. (PubMed id 12586630)1, 9 Dudek A.Z....Slungaard A. (Blood 2003)
  21. Platelet factor 4 is highly upregulated in dendritic cells after severe trauma. (PubMed id 19750196)1, 9 Maier M....Marzi I. (Mol. Med. 2009)
  22. Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin. (PubMed id 17090548)1, 9 Amelot A.A....Le Bonniec B.F. (J. Biol. Chem. 2007)
  23. Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface. (PubMed id 11986215)1, 9 Sachais B.S....Higazi A.A. (Blood 2002)
  24. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. (PubMed id 16304054)1, 9 Rauova L....Poncz M. (Blood 2006)
  25. The control of angiogenesis and tumor invasion by platelet factor-4 and platelet factor-4-derived molecules. (PubMed id 15034805)1, 9 Bikfalvi A. and Gimenez-Gallego G. (Semin. Thromb. Hemost. 2004)
  26. Elevated platelet activation in patients with atopic dermatitis and psoriasis: increased plasma levels of beta-thromboglobulin and platelet factor 4. (PubMed id 18797178)1, 9 Tamagawa-Mineoka R....Kishimoto S. (Allergol Int 2008)
  27. Immune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion. (PubMed id 18539895)1, 9 Xiao Z....Neelamegham S. (Blood 2008)
  28. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. (PubMed id 15304392)1, 9 Rauova L....Sachais B.S. (Blood 2005)
  29. Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms. (PubMed id 15291808)1, 9 Sulpice E....Tobelem G. (Eur. J. Biochem. 2004)
  30. Upstream stimulatory factors stimulate transcription through E-box motifs in the PF4 gene in megakaryocytes. (PubMed id 15187018)1, 9 Okada Y....Doi T. (Blood 2004)
  31. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. (PubMed id 12609838)1, 9 Slungaard A....Lentz S.R. (Blood 2003)
  32. Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. (PubMed id 14652645)1, 9 Pitsilos S....Sachais B.S. (Thromb. Haemost. 2003)
  33. Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells. (PubMed id 12466273)1, 9 Nassar T....Higazi A.A. (J. Biol. Chem. 2003)
  34. Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8. (PubMed id 12223528)1, 9 MartA- F....Rueda F. (J. Leukoc. Biol. 2002)
  35. Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. (PubMed id 11830470)1, 9 Li Z.Q....Poncz M. (Blood 2002)
  36. A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4. (PubMed id 7644496)2, 9 Gupta S.K.... Singh J.P. (Proc. Natl. Acad. Sci. U.S.A. 1995)
  37. Platelet-associated PF-4 as a biomarker of early tumor growth. (PubMed id 17914028)1, 9 Cervi D....Klement G.L. (Blood 2008)
  38. Evidence for a granule targeting sequence within platelet factor 4. (PubMed id 15964840)1, 9 El Golli N....Briquet-Laugier V. (J. Biol. Chem. 2005)
  39. Platelet factor 4 (PF-4)-induced neutrophil adhesion is controlled by src-kinases, whereas PF-4-mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase. (PubMed id 14592823)1, 9 Kasper B....Petersen F. (Blood 2004)
  40. The role of platelet factor 4 in platelet aggregation induced by the antibodies implicated in heparin-induced thrombocytopenia. (PubMed id 11685038)1, 9 Gerotziafas G.T....Samama M.M. (amp 2001)
  41. Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor. (PubMed id 7524669)1, 9 Brown K.J. and Parish C.R. (Biochemistry 1994)
  42. Increased platelet activity in patients with isolated coronary artery ectasia. (PubMed id 17700216)1, 9 Yasar A.S....Sabah I. (Coron. Artery Dis. 2007)
  43. Platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients. (PubMed id 15265941)1, 9 Pervushina O....Petersen F. (J. Immunol. 2004)
  44. Platelet-derived chemokines CXC chemokine ligand (CXCL)7, connective tissue-activating peptide III, and CXCL4 differentially affect and cross-regulate neutrophil adhesion and transendothelial migration. (PubMed id 12193731)1, 9 Schenk B.I....Brandt E. (J. Immunol. 2002)
  45. Mediators of neutrophil recruitment in human abdominal aortic aneurysms. (PubMed id 19201759)1, 9 Houard X....Michel J.B. (Cardiovasc. Res. 2009)
  46. Increased concentration of platelet-derived chemokines in serum of patients with delayed pressure urticaria. (PubMed id 18632422)1, 9 Kasperska-Zajac A....Rogala B. (Eur. Cytokine Netw. 2008)
  47. The effect of secreted heparin-binding proteins on heparin binding to platelets. (PubMed id 8511754)1, 9 Horne M.K. (Thromb. Res. 1993)
  48. Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G. (PubMed id 16317101)1, 9 Schiemann F....Brandt E. (Blood 2006)
  49. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PubMed id 12782716)1, 9 Lasagni L.... Romagnani P. (J. Exp. Med. 2003)
  50. {beta}2 Glycoprotein I ({beta}2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome. (PubMed id 19805618)1, 9 Sikara M.P....Vlachoyiannopoulos P.G. (Blood 2010)
  51. Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level. (PubMed id 15531763)1, 9 Nesmelova I.V....Mayo K.H. (J. Biol. Chem. 2005)
  52. Platelet factor 4 differentially modulates CD4+CD25+ (regulatory) versus CD4+CD25- (nonregulatory) T cells. (PubMed id 15728475)1, 9 Liu C.Y....Visentin G.P. (J. Immunol. 2005)
  53. Diabetes mellitus: a hypercoagulable state. (PubMed id 11259926)7, 9 Carr M.E. (J. Diabetes Complicat. 2001)
  54. Serglycin-binding proteins in activated macrophages and platelets. (PubMed id 8613703)1, 9 Kolset S.O....Ruoslahti E. (J. Leukoc. Biol. 1996)
  55. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. (PubMed id 1688470)1, 9 Maione T.E....Sharpe R.J. (Science 1990)
  56. Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation. (PubMed id 24177324)1 Kowalska M.A....Poncz M. (Arterioscler. Thromb. Vasc. Biol. 2014)
  57. Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4. (PubMed id 24097975)1 Litvinov R.I....Weisel J.W. (J. Biol. Chem. 2013)
  58. Platelet factor 4-positive thrombi adhering to the ventricles of a ventricular assist device in patients with heparin-induced thrombocytopenia type II. (PubMed id 23769097)1 Beiras-Fernandez A....Kur F. (Transplant. Proc. 2013)
  59. Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy. (PubMed id 23352833)1 Nawaz M.I....Struyf S. (Exp. Eye Res. 2013)
  60. Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1. (PubMed id 23536183)2 Kuo J.H.... Sue S.C. (J. Biol. Chem. 2013)
  61. Anti-PF4/heparin antibodies and venous graft occlusion in postcoronary artery bypass surgery patients randomized to postoperative unfractionated heparin or fondaparinux thromboprophylaxis. (PubMed id 23216710)1 Warkentin T.E....Eikelboom J.W. (J. Thromb. Haemost. 2013)
  62. Impact of polymorphisms affecting the ACP1 gene on levels of antibodies against platelet factorA 4-heparin complexes. (PubMed id 23621699)1 Rollin J....Gruel Y. (J. Thromb. Haemost. 2013)
  63. Platelet activation suppresses HIV-1 infection of T cells. (PubMed id 23634812)1 Solomon Tsegaye T....PAPhlmann S. (Retrovirology 2013)
  64. Identification of the platelet-derived chemokine CXCL4/PF-4 as a broad-spectrum HIV-1 inhibitor. (PubMed id 22645343)1 Auerbach D.J....Lusso P. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  65. Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum. (PubMed id 23224555)1 McMorran B.J....Foote S.J. (Science 2012)
  66. Binding of heparin-dependent antibodies to PF4 modified by enoxaparin oligosaccharides: evaluation by surface plasmon resonance and serotonin release assay. (PubMed id 22235911)1 Leroux D....Pouplard C. (J. Thromb. Haemost. 2012)
  67. Genetic variants in platelet factor 4 modulate inflammatory and platelet activation biomarkers. (PubMed id 22763266)1 Bhatnagar P....Fletcher C.A. (Circ Cardiovasc Genet 2012)
  68. Clinical evaluation of acute systemic reaction and detection of IgG antibodies against PF4/heparin complexes in hemodialysis patients. (PubMed id 22088491)1 Matsuo T....Walenga J.M. (Thromb. Res. 2012)
  69. Disruption of PF4/H multimolecular complex formation with a minimally anticoagulant heparin (ODSH). (PubMed id 22318669)1 Joglekar M.V....Arepally G.M. (Thromb. Haemost. 2012)
  70. Dynamic antibody-binding properties in the pathogenesis of HIT. (PubMed id 22577175)1 Sachais B.S....Cines D.B. (Blood 2012)
  71. CXCL4-platelet factor 4, heparin-induced thrombocytopenia and cancer. (PubMed id 22682144)1 Sandset P.M. (Thromb. Res. 2012)
  72. Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome. (PubMed id 22740477)1 Poon T.C....Lo Y.M. (Electrophoresis 2012)
  73. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
  74. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye Bakker P.I. (PLoS Genet. 2012)
  75. VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients. (PubMed id 22402885)1 Peterson J.E....Folkman J. (Angiogenesis 2012)
  76. CXC chemokine ligand 4 (CXCL4) down-regulates CC chemokine receptor expression on human monocytes. (PubMed id 21088050)1 Schwartzkopff F....Brandt E. (Innate Immun 2012)
  77. Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin. (PubMed id 21041299)1 Mosnier L.O. (J. Biol. Chem. 2011)
  78. Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site. (PubMed id 21931859)1 Okada Y....Doi T. (PLoS ONE 2011)
  79. Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4. (PubMed id 21129147)1 Aneja K....Rao A.K. (J. Thromb. Haemost. 2011)
  80. Platelet factor-4 and its p17-70 peptide inhibit myeloma proliferation and angiogenesis in vivo. (PubMed id 21693026)1 Yang L....Zou J. (BMC Cancer 2011)
  81. The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer. (PubMed id 21111666)1 Vandercappellen J....Struyf S. (amp 2011)
  82. CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. (PubMed id 20961394)1 Sarabi A....Von Hundelshausen P. (J. Thromb. Haemost. 2011)
  83. CXCL4 and CXCL10 predict risk of fatal cerebral malaria. (PubMed id 21508508)1 Wilson N.O....Stiles J.K. (Dis. Markers 2011)
  84. Functional divergence between 2 chemokines is conferred by single amino acid change. (PubMed id 20688960)1 Dubrac A....Prats H. (Blood 2010)
  85. Heparin-induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests. (PubMed id 20626620)1 Greinacher A....Warkentin T.E. (J. Thromb. Haemost. 2010)
  86. Heparin-platelet factor 4 antibodies in intensive care patients: an observational seroprevalence study. (PubMed id 19911252)1 Levine R.L....Hursting M.J. (J. Thromb. Thrombolysis 2010)
  87. Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes. (PubMed id 20185595)1 Krane V....Wanner C. (Clin J Am Soc Nephrol 2010)
  88. Prevalence of the antiheparin-platelet factor 4 antibody in hemodialysis (HD) patients and its effects upon dialysis access. (PubMed id 20979952)1 Wallace K....Parry R. (Clin. Nephrol. 2010)
  89. Anti-PF4/heparin antibody formation postorthopedic surgery thromboprophylaxis: the role of non-drug risk factors and evidence for a stoichiometry-based model of immunization. (PubMed id 20050998)1 Warkentin T.E....Greinacher A. (J. Thromb. Haemost. 2010)
  90. CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages. (PubMed id 19910578)1 Gleissner C.A....Ley K. (Circ. Res. 2010)
  91. Differential changes in platelet VEGF, Tsp, CXCL12, and CXCL4 in patients with metastatic cancer. (PubMed id 20182908)1 Wiesner T....Kopp H.G. (amp 2010)
  92. CXCL4-induced monocyte survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1. (PubMed id 20104488)1 Kasper B....Petersen F. (Eur. J. Immunol. 2010)
  93. Evaluation of a new automated panel of assays for the detection of anti-PF4/heparin antibodies in patients suspected of having heparin-induced thrombocytopenia. (PubMed id 20539902)1 Legnani C....Palareti G. (Thromb. Haemost. 2010)
  94. Platelet factor 4 (CXCL4) facilitates human macrophage infection with HIV-1 and potentiates virus replication. (PubMed id 19773294)1 Schwartzkopff F....Clouse K.A. (Innate Immun 2009)
  95. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  96. New insights into the molecular interaction of the C-terminal sequence of CXCL4 with fibroblast growth factor-2. (PubMed id 19245795)1 Ragona L....Bikfalvi A. (Biochem. Biophys. Res. Commun. 2009)
  97. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. (PubMed id 19416867)1 Kim Y.C....Wang S.M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  98. Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancer. (PubMed id 19470732)1 Fiedler G.M....Thiery J. (Clin. Cancer Res. 2009)
  99. Clinical relevance of heparin-PF4 complex antibody in DVT after total joint replacement. (PubMed id 19397833)1 Torigoshi T....Migita K. (BMC Musculoskelet Disord 2009)
  100. The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4. (PubMed id 19625657)1 Schiemann F....Petersen F. (J. Immunol. 2009)
  101. The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis. (PubMed id 18648521)1 Aidoudi S....Bikfalvi A. (PLoS ONE 2008)
  102. Platelet factor-4 is an indicator of blood count recovery in acute myeloid leukemia patients in complete remission. (PubMed id 17998245)1 Kim J.Y....Lee S.W. (amp 2008)
  103. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
  104. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
  105. Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results. (PubMed id 18369708)1 Arepally G.M. and Hursting M.J. (J. Thromb. Thrombolysis 2008)
  106. 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4. (PubMed id 17077331)1 Cheng S.H....Ng H.K. (Blood 2007)
  107. Induction of dendritic cell-like phenotype in macrophages during foam cell formation. (PubMed id 17244792)1 Cho H.J....Ley K. (Physiol. Genomics 2007)
  108. Synovial angiostatic non-ELR CXC chemokines in inflammatory arthritides: does CXCL4 designate chronicity of synovitis? (PubMed id 17265155)1 Erdem H....Sengul A. (Rheumatol. Int. 2007)
  109. CXCL4 in atherosclerosis: possible roles in monocyte arrest and macrophage foam cell formation. (PubMed id 18000592)1 Gleissner C.A. and Ley K. (Thromb. Haemost. 2007)
  110. Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease. (PubMed id 17220270)1 Aivado M....Libermann T.A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
  111. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (Blood 2007)
  112. Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells. (PubMed id 17827342)1 Vandercappellen J....Struyf S. (J. Leukoc. Biol. 2007)
  113. PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. (PubMed id 17218382)1 Lasagni L....Romagnani P. (Blood 2007)
  114. Platelet factor 4 (CXC chemokine ligand 4) differentially regulates respiratory burst, survival, and cytokine expression of human monocytes by using distinct signaling pathways. (PubMed id 17675521)1 Kasper B....Petersen F. (J. Immunol. 2007)
  115. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PubMed id 16806233)1 Ma J....Liew C.C. (Atherosclerosis 2007)
  116. Incidence of antiheparin-platelet factor 4 antibodies and heparin-induced thrombocytopenia in Turkish patients undergoing cardiac surgery. (PubMed id 17636189)1 Demir M....Fareed J. (Clin. Appl. Thromb. Hemost. 2007)
  117. Live attenuated Salmonella carrying platelet factor 4 cDNAs as radioprotectors. (PubMed id 16881736)1 Liu B....Han Z.C. (Radiat. Res. 2006)
  118. Roles of platelet factor 4 in hematopoiesis and angiogenesis. (PubMed id 17381065)1 Maurer A.M....Han Z.C. (Growth Factors 2006)
  119. Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner. (PubMed id 15591119)1 Yu G....Sachais B.S. (Blood 2005)
  120. Regulated expression of platelet factor 4 in human monocytes--role of PARs as a quantitatively important monocyte activation pathway. (PubMed id 15788441)1 Schaffner A....Schaer D.J. (J. Leukoc. Biol. 2005)
  121. Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN. (PubMed id 15994292)1 Gao P....Howard O.M. (Blood 2005)
  122. The human plasma proteome: a nonredundant list developed by combination of four separate sources. (PubMed id 14718574)1 Anderson N.L....Lobley A. (amp 2004)
  123. PREP1, MEIS1 homolog protein, regulates PF4 gene expression. (PubMed id 12732210)1 Okada Y....Doi T. (Biochem. Biophys. Res. Commun. 2003)
  124. Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide. (PubMed id 14575696)1 Fiore M.M. and Kakkar V.V. (Biochem. Biophys. Res. Commun. 2003)
  125. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. (PubMed id 12878486)1 Ma J. and Liew C.C. (J. Mol. Cell. Cardiol. 2003)
  126. Platelet factor 4 inhibits proliferation and cytokine release of activated human T cells. (PubMed id 12097379)1 Fleischer J....Petersen F. (J. Immunol. 2002)
  127. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  128. Signal transduction of chemokine platelet factor 4 in human erythroleukemia cells. (PubMed id 12041672)1 Liu Y.J....Han Z.C. (Int. J. Hematol. 2002)
  129. Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway. (PubMed id 12384403)1 Sulpice E....Tobelem G. (Blood 2002)
  130. Versican interacts with chemokines and modulates cellular responses. (PubMed id 11083865)1 Hirose J....Miyasaka M. (J. Biol. Chem. 2001)
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  296. Platelet-mediated erythromelalgic, cerebral, ocular and coronary microvascular ischemic and thrombotic manifestations in patients with essential thrombocythemia and polycythemia vera: a distinct aspirin-responsive and coumadin-resistant arterial thrombophilia. (PubMed id 17127481)9 Michiels J.J....van Vliet H.H. (Platelets 2006)
  297. Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies. (PubMed id 16873726)9 Greinacher A....Helm C.A. (Arterioscler. Thromb. Vasc. Biol. 2006)
  298. Plasma markers of platelet and polymorphonuclear leukocyte activation in young adults with acute myocardial infarction. (PubMed id 15665428)9 Caimi G....Lo Presti R. (Clin. Hemorheol. Microcirc. 2005)
  299. Unfractionated heparin compared with low-molecular-weight heparin as related to heparin-induced thrombocytopenia. (PubMed id 16093810)9 Walenga J.M....Bakhos M. (Curr Opin Pulm Med 2005)
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  301. Beta thromboglobulin and platelet factor 4 in bronchoalveolar lavage fluid of patients with systemic sclerosis. (PubMed id 15708900)9 Kowal-Bielecka O....Sierakowski S. (Ann. Rheum. Dis. 2005)
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  303. Increased blood coagulation and platelet activation in patients with infective endocarditis and embolic events. (PubMed id 15049384)9 BuyukasA1k N.S....Demirkan D. (Clin Cardiol 2004)
  304. Exposure of fibrinogen-adherent platelets to plasma proteins: a new method for studying protein interactions with platelets. (PubMed id 12889011)9 Broberg M. and Nygren H. (J Biomed Mater Res A 2003)
  305. Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis. (PubMed id 14987915)9 Horigome H....Matsui A. (Thromb. Res. 2003)
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  307. Lipolysis generates platelet dysfunction after in vivo heparin administration. (PubMed id 12241544)9 Muriithi E.W....Wheatley D.J. (Clin. Sci. 2002)
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  309. Platelet concentrates derived from buffy coat and apheresis: biochemical and functional differences. (PubMed id 12383338)9 BAPck M....Heim M.U. (Transfus Med 2002)
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  313. Beta-thromboglobulin and platelet factor 4 levels in post-myocardial infarction patients with major depression. (PubMed id 11927146)9 Kuijpers P.M....Honig A. (Psychiatry Res 2002)
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  316. Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. (PubMed id 11342433)9 Majka M....Ratajczak M.Z. (Blood 2001)
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  318. Validation of blood collection procedures for the determination of circulating vascular endothelial growth factor (VEGF) in different blood compartments. (PubMed id 11471901)9 Dittadi R....Gion M. (Int. J. Biol. Markers 2001)
  319. Heparin-induced thrombocytopenia: natural history, diagnosis, and management. (PubMed id 11530963)9 Deitcher S.R. and Carman T.L. (Vasc Med 2001)
  320. Heparin is not required for detection of antibodies associated with heparin-induced thrombocytopenia/thrombosis. (PubMed id 11433225)9 Visentin G.P....Aster R.H. (J. Lab. Clin. Med. 2001)
  321. Designed beta-sheet peptides that inhibit proliferation and induce apoptosis in endothelial cells. (PubMed id 11824378)9 Mayo K.H....Griffioen A.W. (Angiogenesis 2001)
  322. Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4. (PubMed id 11462931)9 Panasiuk A....Wysocka J. (Hepatogastroenterology 2001)
  323. Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88). (PubMed id 11292191)9 Demir M....Fareed J. (Clin. Appl. Thromb. Hemost. 2001)
  324. Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication. (PubMed id 11782701)9 Diamantopoulos E.J....Raptis S.A. (Int Angiol 2001)
  325. Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation. (PubMed id 11374774)9 King B.O....Chen J.C. (ASAIO J. 2001)
  326. The mechanism of action of thrombin inhibitors. (PubMed id 11156731)9 Bates S.M. and Weitz J.I. (J Invasive Cardiol 2000)
  327. Human LTC-IC can be maintained for at least 5 weeks in vitro when interleukin-3 and a single chemokine are combined with O-sulfated heparan sulfates: requirement for optimal binding interactions of heparan sulfate with early-acting cytokines and matrix proteins. (PubMed id 10607697)9 Gupta P....Verfaillie C.M. (Blood 2000)
  328. Suppressive effect of saprogrelate hydrochloride on Raynaud's phenomenon and respiratory failure in patients with systemic sclerosis. (PubMed id 10728728)9 Kato S....Kumamoto H. (Respirology 2000)
  329. Reduction of heparin dose is not beneficial to platelet function. (PubMed id 10921706)9 Nakajima T....Nitatori T. (Ann. Thorac. Surg. 2000)
  330. Platelet activation and its role in thrombin generation in platelet-induced thrombin generation time. (PubMed id 11150585)9 Radziwon P....Breddin H.K. (Thromb. Res. 2000)
  331. Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation. (PubMed id 11077138)9 Mondillo S....Nami R. (Int. J. Cardiol. 2000)
  332. Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. (PubMed id 10688805)9 Arepally G.M....Poncz M. (Blood 2000)
  333. Affinity purification of heparin-dependent antibodies to platelet factor 4 developed in heparin-induced thrombocytopenia: biological characteristics and effects on platelet activation. (PubMed id 10848821)9 Amiral J....Gruel Y. (Br. J. Haematol. 2000)
  334. Cytokines in WBC-reduced apheresis PCs during storage: a comparison of two WBC-reduction methods. (PubMed id 10988316)9 Wadhwa M....Thorpe R. (Transfusion 2000)
  335. Investigation of a platelet factor 4 polymorphism on the immune response in patients with heparin-induced thrombocytopenia. (PubMed id 10938877)9 Horsewood P. and Kelton J.G. (Platelets 2000)
  336. Platelet factor 4-induced neutrophil-endothelial cell interaction: involvement of mechanisms and functional consequences different from those elicited by interleukin-8. (PubMed id 10590045)9 Petersen F....Brandt E. (Blood 1999)
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  338. Drug-induced immune thrombocytopenia: an overview of pathogenesis. (PubMed id 9930556)9 Aster R.H. (Semin. Hematol. 1999)
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  340. PDGF-AB release during and after haemodialysis procedure. (PubMed id 10528666)9 Cianciolo G....La Hanna G. (Nephrol. Dial. Transplant. 1999)
  341. Chemokine production by human megakaryocytes derived from CD34-positive cord blood cells. (PubMed id 10346982)9 Takeuchi K....Koike K. (Cytokine 1999)
  342. A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation. (PubMed id 9780212)9 Petersen F....Brandt E. (J. Immunol. 1998)
  343. Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. (PubMed id 9768770)9 Mochizuki T....Levy J.H. (Anesth. Analg. 1998)
  344. Platelet count, anti-heparin/platelet factor 4 antibodies and tissue factor pathway inhibitor plasma antigen level in chronic dialysis. (PubMed id 9622039)9 Luzzatto G....Girolami A. (Thromb. Res. 1998)
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  348. Prethrombotic state due to hypercoagulability in patients with permanent transvenous pacemakers. (PubMed id 9342969)9 Ito T....Kamada T. (Angiology 1997)
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  363. Platelet activation is not involved in acceleration of the coagulation system in acute cardioembolic stroke with nonvalvular atrial fibrillation. (PubMed id 7631338)9 Nagao T....Terashi A. ( a journal of cerebral circulation 1995)
  364. Inhibition of development of murine melanoma lung metastases by systemic administration of recombinant platelet factor 4. (PubMed id 7707422)9 Kolber D.L....Maione T.E. (J. Natl. Cancer Inst. 1995)
  365. Three-dimensional structures of alpha and beta chemokines. (PubMed id 7821760)9 Clore G.M. and Gronenborn A.M. (FASEB J. 1995)
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  368. Protective effect of basic fibroblast growth factor-heparin and neurotoxic effect of platelet factor 4 on ischemic neuronal loss and learning disability in gerbils. (PubMed id 7777164)9 Wen T.C....Sakanaka M. (Neuroscience 1995)
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  375. Maturation of human megakaryocytic cell line (CMK-7) on the human umbilical vein endothelial cell (EC) monolayer. (PubMed id 8011988)9 Hoshi M....Mitsui Y. (Int. J. Hematol. 1994)
  376. Platelets deficient in glycoprotein IIIb aggregate normally to collagens type I and III but not to collagen type V. (PubMed id 7694682)9 Kehrel B....Clemetson K.J. (Blood 1993)
  377. A low volume specimen container suitable for monitoring the aPTT of heparinized patients. (PubMed id 8292732)9 Ray M.J....Hawson G.A. (amp 1993)
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  379. Expression of mRNA for serglycin core protein and other platelet alpha granule proteins is increased in human erythroleukemia cells by phorbol myristate acetate. (PubMed id 7504770)9 Schick B.P. and Thornton R.D. (Leukemia 1993)
  380. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression. (PubMed id 7682242)9 Broxmeyer H.E....Ralph P. (J. Immunol. 1993)
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  429. Heparin-induced thrombocytopenia complicated by warfarin-induced skin necrosis. (PubMed id 18541684)9 Howard-Thompson A....Finch C.K. (Am J Health Syst Pharm 2008)
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  456. Prospective evaluation of the '4Ts' score and particle gel immunoassay specific to heparin/PF4 for the diagnosis of heparin-induced thrombocytopenia. (PubMed id 17362241)9 Pouplard C....Gruel Y. (J. Thromb. Haemost. 2007)
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  461. The role of endothelin-1 and selected cytokines in the pathogenesis of Raynaud's phenomenon associated with systemic connective tissue diseases. (PubMed id 16763543)9 Rychlik-Golema W....Adamiec R. (Int Angiol 2006)
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  464. The role of surface PF4: glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT). (PubMed id 16855346)9 Poncz M....Cines D.B. (Pathophysiol. Haemost. Thromb. 2006)
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  467. Serum adenosine deaminase enzyme and plasma platelet factor 4 activities in active pulmonary tuberculosis, HIV-seropositive subjects and cancer patients. (PubMed id 16102836)9 Tarhan G....Cesur S. (J. Infect. 2006)
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  483. Cytokine release of mononuclear leukocytes (PBMC) after contact to a carbonated calcium phosphate bone cement. (PubMed id 16602090)9 Schildhauer T.A....KAPller M. (J Biomed Mater Res A 2006)
  484. Cytokine accumulation in photochemically treated and gamma-irradiated platelet concentrates during storage. (PubMed id 16686848)9 Apelseth T.O....Bruserud O. (Transfusion 2006)
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  503. Safety of recombinant human factor XIII in a cynomolgus monkey model of extracorporeal blood circulation. (PubMed id 16243775)9 Ponce R....Rogge M. (Toxicol Pathol 2005)
  504. Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. (PubMed id 15932816)9 Serebruany V.L....Glassman A.H. (Am J Psychiatry 2005)
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  508. Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement. (PubMed id 16355099)9 Ishibashi H....Ishiguchi T. (Int Angiol 2005)
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  518. Effect of modified ultrafiltration on inflammatory mediators, coagulation factors, and other proteins in blood after an extracorporeal circuit. (PubMed id 15046631)9 Fujita M....Maehara T. (Artif Organs 2004)
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  529. Blood damage related to cardiopulmonary bypass: in vivo and in vitro comparison of two different centrifugal pumps. (PubMed id 15497388)9 Paparella D....De Luca Tupputi Schinosa L. (ASAIO J. 2004)
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  541. Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparan sulphate. (PubMed id 12672474)9 Chadderton N.S. and Stringer S.E. (amp 2003)
  542. Comparison of the effects of cellulose triacetate and polysulfone membrane on GPIIb/IIIa and platelet activation. (PubMed id 12601261)9 Kuragano T....Kanmatsuse K. (Blood Purif. 2003)
  543. Enhanced platelet/endothelial activation in depressed patients with acute coronary syndromes: evidence from recent clinical trials. (PubMed id 12960610)9 Serebruany V.L....O'Connor C.M. (amp 2003)
  544. Anti-thrombin action of low-dose acetylsalicylic acid. (PubMed id 12535860)9 Di Micco B....Ragone R. (Eur. J. Pharmacol. 2003)
  545. Left atrial platelet activity with rheumatic mitral stenosis: correlation study of severity and platelet P-selectin expression by flow cytometry. (PubMed id 14605032)9 Chen M.C....Fu M. (Chest 2003)
  546. Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy. (PubMed id 12912814)9 Serebruany V.L....O'Connor C.M. (Circulation 2003)
  547. Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts. (PubMed id 12781799)9 Michiels J.J. (Pathol. Biol. 2003)
  548. Abciximab inhibits procoagulant activity but not the release reaction upon collagen- or clot-adherent platelets. (PubMed id 12871419)9 Ilveskero S. and Lassila R. (J. Thromb. Haemost. 2003)
  549. Comparative effects of two synthetic oligosaccharides on platelet activation induced by plasma from HIT patients. (PubMed id 12941044)9 Savi P....Herbert J.M. (J. Thromb. Haemost. 2003)
  550. Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy. (PubMed id 12679759)9 Serebruany V.L....Gurbel P.A. (Am. Heart J. 2003)
  551. Aggressive antiplatelet therapy before coronary stent implantation in acute coronary syndrome with essential thrombocythemia--a case report. (PubMed id 12934770)9 Fujimura M....Matsumoto T. (Angiology 2003)
  552. Platelet function assays. (PubMed id 12725958)9 Rand M.L....Packham M.A. (Transfus. Apher. Sci. 2003)
  553. Non-oncologic applications of radiolabeled peptides in nuclear medicine. (PubMed id 14973420)9 Knight L.C. (Q J Nucl Med 2003)
  554. Phosphorylcholine coating offers natural platelet preservation during cardiopulmonary bypass. (PubMed id 11817528)9 De S.F....Van N.G. (Perfusion 2002)
  555. Delayed-onset heparin-induced thrombocytopenia. (PubMed id 11827497)9 Rice L....Francis J.L. (Ann. Intern. Med. 2002)
  556. EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation. (PubMed id 11922610)9 Shimizu S....Morishita K. (Biochem. Biophys. Res. Commun. 2002)
  557. Platelet activation and PDGF-AB release during dialysis. (PubMed id 12518957)9 Donati G....Stefoni S. (Int J Artif Organs 2002)
  558. Antimicrobial peptides from human platelets. (PubMed id 12438321)9 Tang Y.Q....Selsted M.E. (Infect. Immun. 2002)
  559. Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia. (PubMed id 12460234)9 Hayashi M....Inaba N. (Eur. J. Haematol. 2002)
  560. Heparin induces differentiation of CD1a+ dendritic cells from monocytes: phenotypic and functional characterization. (PubMed id 11801647)9 Xia C.Q. and Kao K.J. (J. Immunol. 2002)
  561. Frequency of anti-heparin-platelet factor 4 antibodies in hemodialysis patients and correlation with recurrent vascular access thrombosis. (PubMed id 11835336)9 O'Shea S.I....Ortel T.L. (Am. J. Hematol. 2002)
  562. Fondaparinux sodium. (PubMed id 12532174)9 Reverter J.C. (Drugs Today 2002)
  563. Comparative antithrombotic potencies of direct thrombin inhibitors and low-molecular-weight heparins in an ex vivo human experimental thrombosis model. (PubMed id 12244485)9 Harenberg J....JAPrg I. (Semin. Thromb. Hemost. 2002)
  564. The levels of five markers of hemostasis and endothelial status at different stages of normotensive pregnancy. (PubMed id 11966476)9 Hayashi M....Ohkura T. (Acta Obstet Gynecol Scand 2002)
  565. [Transfer of cDNAs of platelet factor 4 and N-truncated peptide inhibits solid tumor growth in vivo]. (PubMed id 11953124)9 Li Y....Han Z. (Zhonghua Yi Xue Za Zhi 2002)
  566. [The CXC-chemokine platelet factor 4 (PF4) increases KG1a cells adherence and modulates actin polymerization of KG1a cells]. (PubMed id 12905835)9 Lu S.H....Han Z.C. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2002)
  567. Heparin-induced thrombocytopenia-associated thrombosis in pediatric intensive care patients. (PubMed id 11773578)9 Schmugge M....Fischer J.E. (Pediatrics 2002)
  568. Relationships between thrombohemorrhagic complications and platelet function in patients with essential thrombocythaemia. (PubMed id 11559934)9 Raszeja-Specht A....Szutowicz A. (Am. J. Hematol. 2001)
  569. Genetic screening of candidate genes for a prothrombotic interaction with type I protein C deficiency in a large kindred. (PubMed id 11204593)9 Scott B.T....Long G.L. (Thromb. Haemost. 2001)
  570. Gelatinase B functions as regulator and effector in leukocyte biology. (PubMed id 11404367)9 Opdenakker G....Van Damme J. (J. Leukoc. Biol. 2001)
  571. Delayed-onset heparin-induced thrombocytopenia and thrombosis. (PubMed id 11578153)9 Warkentin T.E. and Kelton J.G. (Ann. Intern. Med. 2001)
  572. [Role of the hemostatic system in the progression of acute glomerulonephritis]. (PubMed id 11521520)9 Movchan E.A....Chuprova A.V. (Ter. Arkh. 2001)
  573. Comparison between different laboratory tests for the detection and prevention of heparin-induced thrombocytopenia. (PubMed id 11746104)9 Vitale M....Conte R. (Cytometry 2001)
  574. Matrix metalloproteinase-2 in platelet adhesion to fibrinogen: interactions with nitric oxide. (PubMed id 11433190)9 Martinez A....Radomski M.W. (Med. Sci. Monit. 2001)
  575. Sneddon syndrome with multiple cerebral infarctions 12 years after the onset of livedo vasculitis: a possible involvement of platelet activation. (PubMed id 11603394)9 Matsumura Y....Miyachi Y. (J. Dermatol. 2001)
  576. Intra- and post-dialytic platelet activation and PDGF-AB release: cellulose diacetate vs polysulfone membranes. (PubMed id 11390724)9 Cianciolo G....Stefoni V. (Nephrol. Dial. Transplant. 2001)
  577. SR123781A, a synthetic heparin mimetic. (PubMed id 11372679)9 Herbert J.M....Petitou M. (Thromb. Haemost. 2001)
  578. Low dose systemic heparinization combined with heparin-coated extracorporeal circulation. Effects related to platelets. (PubMed id 11562580)9 Mirow N....KAPrfer R. (J Cardiovasc Surg (Torino) 2001)
  579. Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent diabetic patients with diabetic nephropathy. (PubMed id 11569481)9 Myrup B....Jespersen J. (Scand. J. Clin. Lab. Invest. 2001)
  580. Determination of heparin-platelet factor 4-IgG antibodies improves diagnosis of heparin-induced thrombocytopenia. (PubMed id 11442479)9 Lindhoff-Last E....Bauersachs R. (Br. J. Haematol. 2001)
  581. Biological significance of chemokine receptor expression by normal human megakaryoblasts. (PubMed id 11534779)9 Majka M....Ratajczak M.Z. (Folia Histochem. Cytobiol. 2001)
  582. Does parasitic infection affect platelet factor 4 concentration? (PubMed id 11780555)9 Matowicka-Karna J. and Kemona H. (Rocz. Akad. Med. Bialymst. 2001)
  583. Shear-induced platelet activation and adhesion on human pulmonary artery endothelial cells seeded onto hydrophilic polymers. (PubMed id 11523037)9 Sagnella S....Kottke-Marchant K. (J. Biomed. Mater. Res. 2001)
  584. Von Willebrand factor, a key protein in the exposure of CD62P on platelets. (PubMed id 11511037)9 Broberg M. and Nygren H. (Biomaterials 2001)
  585. Cardiovascular effects of carbon monoxide and cigarette smoking. (PubMed id 11704374)9 Zevin S....Benowitz N.L. (J. Am. Coll. Cardiol. 2001)
  586. Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? (PubMed id 11851938)9 Boehlen F. and Clemetson K.J. (Transfus Med 2001)
  587. Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. (PubMed id 11588041)9 Reilly M.P....McKenzie S.E. (Blood 2001)
  588. Fundamental concepts in the pathobiology of heparin-induced thrombocytopenia. (PubMed id 11155189)9 Januzzi Jr JL . and Jang I.K. (J. Thromb. Thrombolysis 2000)
  589. [Soluble P-selectin - a marker of platelet activation and vessel wall injury: increase of soluble P-selectin in plasma of patients with myocardial infarction, massive atherosclerosis and primary pulmonary hypertension]. (PubMed id 10833791)9 Semenov A.V....Mazurov A.V. (Ter. Arkh. 2000)
  590. Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy. (PubMed id 10826517)9 Freyberger H....Derwahl M. (amp 2000)
  591. Platelet activation in the gyro C1E3 centrifugal pump: comparison with the terumo capiox and the Nikkiso HPM-15. (PubMed id 11119077)9 Kawahito K....Ino T. (Artif Organs 2000)
  592. Plasma adenosine levels increase in women with normal pregnancies. (PubMed id 10819858)9 Yoneyama Y....Araki T. (Am. J. Obstet. Gynecol. 2000)
  593. Suppressive effects of TNF-alpha, TGF-beta1, and chemokines on megakaryocytic colony formation in CD34+ cells derived from umbilical cord blood compared with mobilized peripheral blood and bone marrow. (PubMed id 10813532)9 Lu L....Broxmeyer H.E. (amp 2000)
  594. Effect of i.v. tenoxicam during caesarean delivery on platelet activity. (PubMed id 10786742)9 Elhakim M....Mekawy M. (Acta Anaesthesiol Scand 2000)
  595. Alterations in coagulation after implantation of a pulsatile Novacor LVAD and the axial flow MicroMed DeBakey LVAD. (PubMed id 10969675)9 Koster A....Hetzer R. (Ann. Thorac. Surg. 2000)
  596. Jostra Rota Flow RF-30 pump system: a new centrifugal blood pump for cardiopulmonary bypass. (PubMed id 10886061)9 Orime Y....Suzuki M. (Artif Organs 2000)
  597. Heparin-induced thrombocytopenia. (PubMed id 10629596)9 Fabris F....Girolami A. (Haematologica 2000)
  598. Modulatory roles of RANTES in IL-4 production by human blood CD4(+)T cells. (PubMed id 10975998)9 Saito S....Kawakami Y. (Cytokine 2000)
  599. Acute effects of nicotine infusion on platelets in nicotine users with normal and impaired renal function. (PubMed id 10698667)9 Whiss P.A....Larsson R. (Toxicol. Appl. Pharmacol. 2000)
  600. Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. (PubMed id 11110672)9 Clemetson K.J....Wells T.N. (Blood 2000)
  601. Changes of the hemostatic network in critically ill patients--is there a difference between sepsis, trauma, and neurosurgery patients? (PubMed id 10708181)9 Boldt J....Piper S. (Crit. Care Med. 2000)
  602. Suppressive effect of sarpogrelate hydrochloride on respiratory failure and right ventricular failure with pulmonary hypertension in patients with systemic sclerosis. (PubMed id 11191719)9 Kato S....Kaneko N. (J. Int. Med. Res. 2000)
  603. Platelet factor 4 as a marker of platelet activation in patients with acute myocardial infarction. (PubMed id 11712446)9 Dymicka-Piekarska V....Bychowski J. (Rocz. Akad. Med. Bialymst. 2000)
  604. Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO- alpha and leaves RANTES and MCP-2 intact. (PubMed id 11023497)9 Van den Steen P.E.... Opdenakker G. (Blood 2000)
  605. Coagulation system and platelets are fully activated in uncomplicated sepsis. (PubMed id 10708182)9 Mavrommatis A.C....Zakynthinos S. (Crit. Care Med. 2000)
  606. The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. (PubMed id 10807774)9 Sungaran R....Chong B.H. (Blood 2000)
  607. Molecular mechanisms of platelet exocytosis: requirements for alpha-granule release. (PubMed id 10673384)9 Lemons P.P....Whiteheart S.W. (Biochem. Biophys. Res. Commun. 2000)
  608. Newer antithrombin agents in acute coronary syndromes. (PubMed id 10577463)9 Antman E.M. and Cohen M. (Am. Heart J. 1999)
  609. Nitric oxide diffusion across membrane lungs protects platelets during simulated extracorporeal circulation. (PubMed id 10231347)9 Keh D....Gerlach H. (Eur. J. Clin. Invest. 1999)
  610. Takayasu's arteritis associated with factor V Leiden. (PubMed id 10072118)9 Shin D.D. and Godwin J.E. (Am. J. Hematol. 1999)
  611. Measurement of endogenous and exogenous alpha-granular platelet proteins in patients with immune and nonimmune thrombocytopenia. (PubMed id 10468871)9 Hughes M....Kelton J.G. (Br. J. Haematol. 1999)
  612. Changes in platelet ATP secretion and aggregation during pregnancy and in preeclampsia. (PubMed id 10452571)9 Hayashi M....Mitsuya K. (Am. J. Med. Sci. 1999)
  613. The rationale and future potential of angiogenesis inhibitors in neoplasia. (PubMed id 10439927)9 Gasparini G. (Drugs 1999)
  614. Physical mapping of the CXC chemokine locus on human chromosome 4. (PubMed id 10343098)9 O'Donovan N....Morgan J.G. (Cytogenet. Cell Genet. 1999)
  615. Functional heterogeneity of antiheparin-platelet factor 4 antibodies: implications in the pathogenesis of the HIT syndrome. (PubMed id 10726034)9 Ahmad S....Fareed J. (Clin. Appl. Thromb. Hemost. 1999)
  616. Significantly elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic dermatitis. (PubMed id 10319581)9 Watanabe O....Nakamura Y. (J. Hum. Genet. 1999)
  617. Selective activity of various antiviral compounds against HHV-7 infection. (PubMed id 10480261)9 Zhang Y....De Clercq E. (Antiviral Res. 1999)
  618. [Decreased plasma soluble P-selectin level in coronary sinus after successful coronary angioplasty in patients with unstable angina]. (PubMed id 10354952)9 Doi N....Dohi K. (J Cardiol 1999)
  619. A prospective study of G-CSF effects on hemostasis in allogeneic blood stem cell donors. (PubMed id 10373063)9 LeBlanc R....Cantin G. (Bone Marrow Transplant. 1999)
  620. Angiogenesis inhibitors overcome tumor induced endothelial cell anergy. (PubMed id 9935216)9 Griffioen A.W....Groenewegen G. (Int. J. Cancer 1999)
  621. [Preeclampsia not (yet) predictable from the blood platelet count]. (PubMed id 10086090)9 Lazarov R....Boer K. (Ned Tijdschr Geneeskd 1999)
  622. Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. (PubMed id 10593869)9 Sakiyama S.E....Hubbell J.A. (FASEB J. 1999)
  623. Role of a serine/threonine kinase, Mst1, in megakaryocyte differentiation. (PubMed id 10581000)9 Sun S. and Ravid K. (J. Cell. Biochem. 1999)
  624. Synthesis of thrombin-inhibiting heparin mimetics without side effects. (PubMed id 10201371)9 Petitou M....Herbert J.M. (Nature 1999)
  625. Epinephrine promotes IL-8 production in human leukocytes via an effect on platelets. (PubMed id 10348705)9 Engstad C.S....Osterud B. (Thromb. Haemost. 1999)
  626. Increased formation of thromboxane in vivo in humans with mastocytosis. (PubMed id 10417625)9 Morrow J.D....Guzzo C. (J. Invest. Dermatol. 1999)
  627. Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: a key to study an angiogenic marker in vivo? (PubMed id 10509160)9 Wynendaele W....van Oosterom A.T. (Ann. Oncol. 1999)
  628. Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action. (PubMed id 10419890)9 Jouan V....Bikfalvi A. (Blood 1999)
  629. Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation. (PubMed id 9568742)9 BrAPijersAcn A....Hjemdahl P. (Atherosclerosis 1998)
  630. Cardiology for the primary care provider: heparin-induced thrombocytopenia. (PubMed id 9496863)9 Benton R.E. and Gersh B.J. (South. Med. J. 1998)
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  632. Heparin-induced thrombocytopenia: diagnostic tests and biological mechanisms. (PubMed id 10097819)9 Amiral J. and Meyer D. (Baillieres Clin. Haematol. 1998)
  633. CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2. (PubMed id 9551928)9 Sanchez X....Navarro J. (J. Immunol. 1998)
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  636. Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes. (PubMed id 9702994)9 Fareed J....Bick R. (Clin. Chem. 1998)
  637. In vivo platelet and T-lymphocyte activities during pulmonary tuberculosis. (PubMed id 9877494)9 BA1yA1kaA9ik Y....DA1ndar S.V. (Eur. Respir. J. 1998)
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  639. Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids. (PubMed id 9465307)9 Modi W.S. and Chen Z.Q. (Genomics 1998)
  640. Soluble P-selectin is released from activated platelets in vivo during hemodialysis. (PubMed id 9496730)9 Kawabata K....Makino H. (Nephron 1998)
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  642. Evaluation of platelet damage in two different centrifugal pumps based on measurements of alpha-granule packing proteins. (PubMed id 9609343)9 Mohara J....Fuse K. (Artif Organs 1998)
  643. The role of epidermal growth factor in platelet-endothelium interactions. (PubMed id 9670106)9 Lukaszyk A....Bielawiec M. (J. Physiol. Pharmacol. 1998)
  644. Association between carotid atherosclerosis and hemostatic markers in patients with cerebral small artery disease. (PubMed id 9607119)9 Nomura E....Nakamura S. (amp 1998)
  645. In vitro effects of the platelet glycoprotein IIb/IIIa receptor antagonist c7E3 Fab on the activated clotting time. (PubMed id 9024148)9 Ammar T....Coller B.S. (Circulation 1997)
  646. Chemokine antagonists that discriminate between interleukin-8 receptors. Selective blockers of CXCR2. (PubMed id 9195914)9 Jones S.A....Baggiolini M. (J. Biol. Chem. 1997)
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  650. Molecular modeling of interleukin-8 receptor beta and analysis of the receptor-ligand interaction. (PubMed id 9464567)9 Luo Z....Huang Z. (Protein Eng. 1997)
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  654. Biochemical markers of coagulation activation in mitral stenosis, atrial fibrillation, and cardiomyopathy. (PubMed id 8994731)9 Ikeda U....Shimada K. (Clin Cardiol 1997)
  655. The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence. (PubMed id 9047370)9 Malkowski M.G....Edwards B.F. (J. Mol. Biol. 1997)
  656. A natural motif approach to protein design: a synthetic leucine zipper peptide mimics the biological function of the platelet factor 4 protein. (PubMed id 9202142)9 Butcher D.J....Huang Z. (FEBS Lett. 1997)
  657. Coagulation and fibrinolysis system in aortic surgery under deep hypothermic circulatory arrest with aprotinin: the importance of adequate heparinization. (PubMed id 9386127)9 Okita Y....Kawashima Y. (Circulation 1997)
  658. Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. (PubMed id 9423790)9 Gresele P....DavA- G. (Thromb. Haemost. 1997)
  659. Specific binding of the chemokine platelet factor 4 to heparan sulfate. (PubMed id 9252363)9 Stringer S.E. and Gallagher J.T. (J. Biol. Chem. 1997)
  660. Recognition and management of heparin-induced thrombocytopenia (HIT) and thrombosis. (PubMed id 9469632)9 Alving B.M. and Krishnamurti C. (Semin. Thromb. Hemost. 1997)
  661. Expression of prostacyclin receptor in human megakaryocytes. (PubMed id 9242534)9 Sasaki Y....Nakao K. (Blood 1997)
  662. Apyrase, ascorbic acid and aprotinin ameliorate the storage lesion in pelleted platelet preparations. (PubMed id 9408586)9 Mrowiec Z.R....Puszkin E.G. (amp 1997)
  663. Application of argatroban, direct thrombin inhibitor, in heparin-intolerant patients requiring extracorporeal circulation. (PubMed id 9288875)9 Matsuo T....Kario K. (Artif Organs 1997)
  664. Diagnosis of heparin-induced thrombocytopenia in the vascular surgery patient. (PubMed id 9122872)9 Jackson M.R....Alving B.M. (Surgery 1997)
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  666. Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization. (PubMed id 9166836)9 Kikuchi J....Miura Y. (Blood 1997)
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  672. Postburn edema and related changes in interleukin-2, leukocytes, platelet activation, endothelin-1, and C1 esterase inhibitor. (PubMed id 9095417)9 Kowal-Vern A....Gamelli R.L. (amp 1997)
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  674. An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. (PubMed id 9207209)9 Doi T.... Imanishi T. (Biochem. Biophys. Res. Commun. 1997)
  675. Interaction of a new depolymerized holothurian glycosaminoglycan with proteins in human plasma. (PubMed id 8840467)9 Minamiguchi K....Kitazato K. (Thromb. Res. 1996)
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  679. RANTES and macrophage inflammatory protein 1 alpha selectively enhance immunoglobulin (IgE) and IgG4 production by human B cells. (PubMed id 8642352)9 Kimata H....Furusho K. (J. Exp. Med. 1996)
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  682. Effect of different dialysis membranes on platelet function. A tool for biocompatibility evaluation. (PubMed id 8841854)9 De Sanctis L.B....Buttazzi R. (Int J Artif Organs 1996)
  683. Alterations in platelet function in patients receiving interleukin-6 as cytokine therapy. (PubMed id 8689424)9 Oleksowicz L....Dutcher J.P. (Cancer Invest. 1996)
  684. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)9 Loetscher M.... Moser B. (J. Exp. Med. 1996)
  685. In vitro comparison of the effects of contrast media on coagulation and platelet activation. (PubMed id 8899149)9 Corot C....Sabattier V. (amp 1996)
  686. Restoration of the normal coagulation process: advances in therapies to antagonize heparin. (PubMed id 8938285)9 D'Ambra M. (J. Cardiovasc. Pharmacol. 1996)
  687. Effects of sodium ozagrel on hemostatic markers and cerebral blood flow in lacunar infarction. (PubMed id 8937792)9 Oishi M....Takasu T. (Clin Neuropharmacol 1996)
  688. Characteristics of vasospastic angina with exercised-induced ischemia--analysis of parameters of hemostasis and fibrinolysis. (PubMed id 8803721)9 Sakata K....Takada A. (Jpn. Circ. J. 1996)
  689. A recipe for designing water-soluble, beta-sheet-forming peptides. (PubMed id 8819163)9 Mayo K.H....Park H. (Protein Sci. 1996)
  690. Reversible inhibition by protamine of human synovial and rabbit platelet secretory phospholipase A2. (PubMed id 8679688)9 Emadi S....Hatmi M. (Biochim. Biophys. Acta 1996)
  691. Induction of inhibitory activity for B cell differentiation in human CD8 T cells with pokeweed mitogen, dimaprit, and cAMP upregulating agents: countersuppressive effect of platelet factor 4. (PubMed id 8964082)9 Crisi G.M....Thorbecke G.J. (Cell. Immunol. 1996)
  692. Effect of defibrotide on platelet function. (PubMed id 8807724)9 Ulutin O.N....Yardimci T. (Semin. Thromb. Hemost. 1996)
  693. Plasma levels of molecular markers of blood coagulation and fibrinolysis in progressive systemic sclerosis (PSS). (PubMed id 8785174)9 Maeda M....Mori S. (J. Dermatol. Sci. 1996)
  694. Effect of spirapril and hydrochlorothiazide on platelet function and euglobulin clot lysis time in patients with mild hypertension. (PubMed id 8873580)9 Gleerup G....Winther K. (Angiology 1996)
  695. Species specific immunoassays to measure blood platelet and coagulation activation in the rat. (PubMed id 8972036)9 Ravanat C....Cazenave J.P. (Thromb. Haemost. 1996)
  696. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1. (PubMed id 8625964)9 Legler D.F....Moser B. (Eur. J. Immunol. 1996)
  697. Blood clotting in minimally altered whole blood. (PubMed id 8896408)9 Rand M.D....Mann K.G. (Blood 1996)
  698. Platelets stored in a glucose-free additive solution or in autologous plasma--an ultrastructural and morphometric evaluation. (PubMed id 8837351)9 Klinger M.H....KlA1ter H. (Vox Sang. 1996)
  699. [Positive and negative regulation of megakaryocytopoiesis]. (PubMed id 9074717)9 Bellucci S....Caen J.P. (C. R. Seances Soc. Biol. Fil. 1996)
  700. Macrophage-stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family. (PubMed id 8695717)9 Broxmeyer H.E....Leonard E.J. (Ann. Hematol. 1996)
  701. Effects of basophil-priming and stimulating cytokines on histamine release from isolated human skin mast cells. (PubMed id 8844126)9 Nitschke M....Amon U. (Arch. Dermatol. Res. 1996)
  702. Generation of antibodies to heparin-PF4 complexes without thrombocytopenia in patients treated with unfractionated or low-molecular-weight heparin. (PubMed id 8638647)9 Amiral J....Meyer D. (Am. J. Hematol. 1996)
  703. Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor. (PubMed id 8962720)9 Yoshida A....Zetter B.R. (Growth Factors 1996)
  704. Quality of pooled platelet concentrates prepared from buffy coats and stored in an additive solution after filtration. (PubMed id 7880932)9 Koerner K....Kubanek B. (Ann. Hematol. 1995)
  705. The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. (PubMed id 7790818)9 Luster A.D....Leder P. (J. Exp. Med. 1995)
  706. Thromboxane B2 blood levels and incipient system clotting in heparin free hemodialysis. (PubMed id 7640422)9 Keller F....Meinhold H. (ASAIO J. 1995)
  707. Platelet function and fibrinolytic activity during rest and exercise in borderline hypertensive patients. (PubMed id 7601202)9 Gleerup G....Winther K. (Eur. J. Clin. Invest. 1995)
  708. Heparin-induced thrombocytopenia and thrombosis. (PubMed id 9372019)9 Visentin G.P. and Aster R.H. (Curr. Opin. Hematol. 1995)
  709. Bacteria/blood/material interactions. I. Injected and preseeded slime-forming Staphylococcus epidermidis in flowing blood with biomaterials. (PubMed id 7622530)9 Brunstedt M.R....Anderson J.M. (J. Biomed. Mater. Res. 1995)
  710. Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species. (PubMed id 8589212)9 Ravanat C....Legrand C. (amp 1995)
  711. A comprehensive hematologic study in calves with total artificial hearts. (PubMed id 8573803)9 Harasaki H....Massiello A. (ASAIO J. 1995)
  712. A study of platelet functions, some hemostatic and fibrinolytic parameters in relation to serotonin in hemodialyzed patients under erythropoietin therapy. (PubMed id 7740505)9 Malyszko J....Buczko W. (Thromb. Res. 1995)
  713. Effect of circulating epinephrine on platelet function and hematocrit. (PubMed id 7737722)9 Kjeldsen S.E....Julius S. (Hypertension 1995)
  714. Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. (PubMed id 7740492)9 Amiral J....Meyer D. (Thromb. Haemost. 1995)
  715. Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. (PubMed id 7723894)9 Mezzano S....Mezzano D. (Nephron 1995)
  716. Effects of beraprost sodium, a new prostaglandin I2 analog, on parameters of hemostasis, fibrinolysis, and myocardial ischemia in patients with exertional angina. (PubMed id 8547211)9 Sakata K....Takada A. (Cardiovasc Drugs Ther 1995)
  717. [Effect of rantes (regulated on activation, normal T expressed and secreted) on eosinophil adhesion to plasma coated glass using eosinophilic cell line (EoL-1)]. (PubMed id 7541195)9 Kakazu T....Nakajima S. (Arerugi 1995)
  718. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. (PubMed id 7706245)9 Malkowski M.G.... Edwards B.F.P. (J. Biol. Chem. 1995)
  719. Platelet and coagulation factor variations induced in vitro by polyethylene terephthalate (Dacron) coated with pyrolytic carbon. (PubMed id 8580259)9 Cenni E....Pizzoferrato A. (Biomaterials 1995)
  720. [Lipoprotein(a) and hemostasis activation markers in angina pectoris]. (PubMed id 7656834)9 Tsakiris D.A....Marbet G.A. (Dtsch. Med. Wochenschr. 1995)
  721. Characteristic biological features of human megakaryoblastic leukaemia cell lines. (PubMed id 7564468)9 Hassan H.T. and Freund M. (Leuk. Res. 1995)
  722. Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. (PubMed id 7545174)9 Aronica S.M....Broxmeyer H.E. (J. Biol. Chem. 1995)
  723. The role of CXC chemokines as regulators of angiogenesis. (PubMed id 8574748)9 Strieter R.M....Kunkel S.L. (Shock 1995)
  724. The three-dimensional solution structure of RANTES. (PubMed id 7542919)9 Chung C.-W.... Wells T.N.C. (Biochemistry 1995)
  725. Platelet activation and fibrinolysis in large bowel cancer. (PubMed id 7637955)9 Abbasciano V....Zavagli G. (Oncology 1995)
  726. Anti-inflammatory activity of an orally active peptide sequence from PF-4 on acute inflammation and DTH. (PubMed id 8548397)9 Talmadge J.E....Counts D.F. (Inflamm. Res. 1995)
  727. [Changes in platelet function in patients with arterial hypertension]. (PubMed id 7571480)9 MalA1 J....JebavA1 L. (Vnitr Lek 1995)
  728. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation. (PubMed id 7639692)9 Barella L.... Moser B. (Biochem. J. 1995)
  729. Fibrinolysis profiles and platelet activation after endothelial cell seeding of prosthetic vascular grafts. (PubMed id 8746831)9 Smyth J.V....Walker M.G. (Ann Vasc Surg 1995)
  730. A mapping study of 13 genes on human chromosome bands 4q11--&gt;q25. (PubMed id 7698025)9 Chen C.S....Kersey J.H. (Cytogenet. Cell Genet. 1995)
  731. Calcium supplementation attenuates an enhanced platelet function in salt-loaded mildly hypertensive patients. (PubMed id 7607719)9 Saito K....Yokoyama M. (Hypertension 1995)
  732. Importance of PF4 in heparin-induced thrombocytopenia: confirmation with gray platelets. (PubMed id 7858274)9 Horne M.K. and Alkins B.R. (Blood 1995)
  733. Platelet function and fibrinolytic activity in hypertensive and normotensive sleep apnea patients. (PubMed id 7610315)9 RAYngemark C....Winther K. (Sleep 1995)
  734. [The effect of indobufen on platelet function and dialyzer regeneration in patients on hemodialysis]. (PubMed id 7491347)9 SokoA8owska B....Walter-Croneck A. (Pol. Arch. Med. Wewn. 1995)
  735. Migraine--a haematological disorder? (PubMed id 8685625)9 MalA1 J....BlA!ha M. (Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove 1995)
  736. Neutralization of heparin activity by neutrophil lactoferrin. (PubMed id 7811995)9 Wu H.F....Church F.C. (Blood 1995)
  737. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. (PubMed id 7592998)9 Strieter R.M....Marriott D. (J. Biol. Chem. 1995)
  738. IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. (PubMed id 7593232)9 Majumdar A....Seidman M.M. (J. Cell. Physiol. 1995)
  739. [Effect of cytokine RANTES on induction of activated eosinophils]. (PubMed id 8583714)9 Kakazu T....Nakajima S. (Nihon Kyobu Shikkan Gakkai Zasshi 1995)
  740. ARIC hemostasis study--IV. Intraindividual variability and reliability of hemostatic factors. The Atherosclerosis Risk in Communities (ARIC). (PubMed id 7792740)9 Nguyen N.D....Wu K.K. (Thromb. Haemost. 1995)
  741. Cellular interactions in tissue factor expression by blood monocytes. (PubMed id 7544163)9 Osterud B. (amp 1995)
  742. Thrombin generation as an acute effect of cigarette smoking. (PubMed id 8017287)9 Kimura S....Shimada K. (Am. Heart J. 1994)
  743. Heparin-coated oxygenators significantly reduce contact system activation in an in vitro cardiopulmonary bypass model. (PubMed id 7865672)9 Wendel H.P....Hoffmeister H.E. (amp 1994)
  744. RANTES- and interleukin-8-induced responses in normal human eosinophils: effects of priming with interleukin-5. (PubMed id 7515718)9 Schweizer R.C....Koenderman L. (Blood 1994)
  745. Functional and ligand binding specificity of the rabbit neutrophil IL-8 receptor. (PubMed id 8133060)9 Thomas K.M....Navarro J. (J. Immunol. 1994)
  746. Angiogenesis: an update. (PubMed id 7534514)9 DA-az-Flores L....Varela H. (Histol. Histopathol. 1994)
  747. Effect of two lipid emulsions on platelet function. (PubMed id 7803993)9 Porta I....Schwartz S. (Infusionsther Transfusionsmed 1994)
  748. Platelet aggregation, coronary artery disease progression and future coronary events. (PubMed id 8109546)9 Lam J.Y....Waters D. (Am. J. Cardiol. 1994)
  749. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators. (PubMed id 7923645)9 (Circulation 1994)
  750. Differential binding of chemokines to glycosaminoglycan subpopulations. (PubMed id 7922353)9 Witt D.P. and Lander A.D. (Curr. Biol. 1994)
  751. Increased heparin-releasable platelet factor 4 and D dimer in patients one month after the onset of acute myocardial infarction: persistent activation of platelets and the coagulation/fibrinolytic system. (PubMed id 7737755)9 Abe S....Atsuchi Y. (Int. J. Cardiol. 1994)
  752. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. (PubMed id 8276799)9 Loetscher M....Moser B. (J. Biol. Chem. 1994)
  753. Different effects of strenuous exercise and moderate exercise on platelet function in men. (PubMed id 7994833)9 Wang J.S....Chen H.I. (Circulation 1994)
  754. The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. (PubMed id 8077676)9 Paolini J.F....Krangel M.S. (J. Immunol. 1994)
  755. Effects of hypoxia on platelet activation in pilots. (PubMed id 7945133)9 Shen D. and Wang Y. (Aviat Space Environ Med 1994)
  756. Absence of a prothrombotic state in restenotic patients? (PubMed id 7952409)9 Brack M.J....Gershlick A.H. (Coron. Artery Dis. 1994)
  757. Biocompatibility of heparin-coated membrane oxygenator during cardiopulmonary bypass. (PubMed id 7887827)9 Hatori N....Tanaka S. (Artif Organs 1994)
  758. Effect of atrial fibrillation on the fibrino-coagulation system--study in patients with paroxysmal atrial fibrillation. (PubMed id 7807680)9 Sohara H. and Miyahara K. (Jpn. Circ. J. 1994)
  759. Heparin-coated cardiopulmonary bypass circuits: hemostatic alterations and postoperative blood loss. (PubMed id 7944696)9 Wagner W.R....Marrone G.C. (Ann. Thorac. Surg. 1994)
  760. [Relationship of mitral valve area to hemostatic condition in rheumatic mitral stenosis]. (PubMed id 7932073)9 Kataoka H....Mikuriya Y. (J Cardiol 1994)
  761. Chemokines, inflammation and the immune system. (PubMed id 7584498)9 Taub D.D. and Oppenheim J.J. (Ther Immunol 1994)
  762. [The effect of quantum hemotherapy on the plasma hemostatic indices and fibrinolysis in patients with unstable angina]. (PubMed id 7831873)9 BabiA- L.N....Nikandrova N.L. (Lik. Sprava 1994)
  763. Fish oils and their possible role in the treatment of cardiovascular diseases. (PubMed id 7938179)9 Semplicini A. and Valle R. (amp 1994)
  764. Effects of interleukin-2 administration on platelet function in cancer patients. (PubMed id 8296793)9 Oleksowicz L....Dutcher J.P. (Am. J. Hematol. 1994)
  765. Plasma beta-thromboglobulin and platelet factor 4 are not increased in insulin-dependent diabetic patients with microalbuminuria. (PubMed id 7827349)9 Gruden G....Pagano G. (Acta Diabetol 1994)
  766. Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4. (PubMed id 8193358)9 Kelton J.G....Horsewood P. (Blood 1994)
  767. Beta-thromboglobulin (beta tg) and platelet factor 4 (PF4) in patients with myeloproliferative diseases. (PubMed id 7710537)9 Fabris F....Cella G. (Thromb. Haemost. 1994)
  768. Expression of the Duffy antigen in K562 cells. Evidence that it is the human erythrocyte chemokine receptor. (PubMed id 8132497)9 Chaudhuri A....Horuk R. (J. Biol. Chem. 1994)
  769. [Evaluation of platelet hemostasis in patients with chronic renal failure]. (PubMed id 7975649)9 Krawczyk W....SokoA8owska B. (Wiad. Lek. 1994)
  770. Coagulation and inhibitory and fibrinolytic proteins in essential hypertension. (PubMed id 8400086)9 Vaziri N.D....Neutel J.M. (J. Am. Soc. Nephrol. 1993)
  771. The impact of static work on fibrinolysis and platelet function. (PubMed id 8303686)9 Vind J....Winther K. (Thromb. Res. 1993)
  772. [Other mediators of inflammation and sepsis]. (PubMed id 8469893)9 Lamy M....Damas P. (Rev Prat 1993)
  773. Development of a rapid and sensitive chromogenic heparin assay for clinical use. (PubMed id 8477906)9 Wagenvoord R.J....Hemker H.C. (Haemostasis 1993)
  774. Altered platelet function associated with the bronchial hyperresponsiveness accompanying nocturnal asthma. (PubMed id 8473678)9 Gresele P....Nenci G.G. (J. Allergy Clin. Immunol. 1993)
  775. Plasma parameters of the prothrombotic state in chronic uremia. (PubMed id 8446263)9 Sagripanti A....Barsotti G. (Nephron 1993)
  776. Single-dose effect of enteric-coated aspirin on platelet function and thromboxane generation in middle-aged men. (PubMed id 8477113)9 Mohri H. and Ohkubo T. (Ann Pharmacother 1993)
  777. Comparative effects of suppressive cytokines on isolated single CD34(3+) stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum. (PubMed id 7691634)9 Lu L....Broxmeyer H.E. (Exp. Hematol. 1993)
  778. Cigarette-smoking affects platelets and endothelium in chronic hemodialysis patients. (PubMed id 8341380)9 Davis J.W....Wiegmann T. (Nephron 1993)
  779. Study of platelet function in patients with sickle cell anemia during steady state and vaso-occlusive crisis. (PubMed id 8212998)9 Papadimitriou C.A....Lali P. (Acta Haematol. 1993)
  780. Cationic proteins induce airway hyperresponsiveness dependent on charge interactions. (PubMed id 8385431)9 Coyle A.J....Irvin C.G. (Am. Rev. Respir. Dis. 1993)
  781. Are megakaryocytes and endothelial cells sisters? (PubMed id 8505591)9 Han Z.C. and Caen J.P. (J. Lab. Clin. Med. 1993)
  782. Some relations between light transmission changes and biochemical parameters of stored platelet packs. (PubMed id 8259559)9 JAoremo P....Kutti J. (Thromb. Haemost. 1993)
  783. [Vascular function parameters in idiopathic and quartz-induced progressive scleroderma]. (PubMed id 8276590)9 Haustein U.F....Krusche U. ( Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 1993)
  784. Map of seven polymorphic markers on rat chromosome 14: linkage conservation with human chromosome 4. (PubMed id 8431642)9 Remmers E.F....Wilder R.L. (Mamm. Genome 1993)
  785. Further evidence that alpha-granule components such as platelet factor 4 are involved in platelet-IgG-heparin interactions during heparin-associated thrombocytopenia. (PubMed id 8236153)9 Gruel Y....Wautier J.L. (Thromb. Haemost. 1993)
  786. Inherited abnormalities in platelet organelles and platelet formation and associated altered expression of low molecular weight guanosine triphosphate-binding proteins in the mouse pigment mutant gunmetal. (PubMed id 8490171)9 Swank R.T....Novak E.K. (Blood 1993)
  787. Nicotine effects on eicosanoid formation and hemostatic function: comparison of transdermal nicotine and cigarette smoking. (PubMed id 7691912)9 Benowitz N.L....Zhang Q. (J. Am. Coll. Cardiol. 1993)
  788. Numerical and functional modifications in platelets induced by polyester coated by a hydrophilic polymer. (PubMed id 8399951)9 Cenni E....Pizzoferrato A. (Biomaterials 1993)
  789. Melanoma growth-stimulatory activity/GRO decreases collagen expression by human fibroblasts. Regulation by C-X-C but not C-C cytokines. (PubMed id 8419336)9 Unemori E.N....Horuk R. (J. Biol. Chem. 1993)
  790. Hemostasis variables in type I diabetic patients without demonstrable vascular complications. (PubMed id 8375244)9 el Khawand C....Buysschaert M. (Diabetes Care 1993)
  791. Continuous intravenous dosing with ciprostene using a portable pump in ambulatory patients. (PubMed id 8440764)9 Wolf D.L....Luderer J.R. (J Clin Pharmacol 1993)
  792. Platelet activation and fibrinopeptide formation in pulmonary hypertension. (PubMed id 8252943)9 Schulman L.L....Owen J. (Chest 1993)
  793. Platelet hyperactivation in patients with essential thrombocythemia is not associated with vascular endothelial cell damage as judged by the level of plasma thrombomodulin, protein S, PAI-1, t-PA and vWF. (PubMed id 8128427)9 Bellucci S....Boffa M.C. (Thromb. Haemost. 1993)
  794. Evaluation of risk of thrombosis during use of low-dose ethinylestradiol-desogestrel oral contraceptive. (PubMed id 8237574)9 Massafra C....Colombini G. (Adv Contracept 1993)
  795. Platelet alpha-granules. (PubMed id 8467233)9 Harrison P. and Cramer E.M. (Blood Rev. 1993)
  796. [The antithrombogenic properties of the vascular wall and platelet aggregation in patients with atherosclerosis of the arteries of the lower extremities following a course of treatment with UV-irradiated autologous blood transfusion]. (PubMed id 8020715)9 Adamchik A.S....Belov I.u.V. (Gematol Transfuziol 1993)
  797. Platelet aggregability in patients with a VVI pacemaker. (PubMed id 7680451)9 Fazio S....Sacca L. (Pacing Clin Electrophysiol 1993)
  798. Interaction of immobilised unfractionated and LMW heparins with proteins in whole human plasma. (PubMed id 8165617)9 Zammit A....Dawes J. (Thromb. Haemost. 1993)
  799. Human platelets secrete chemotactic activity for eosinophils. (PubMed id 8417801)9 Burgers J.A....Akkerman J.W. (Blood 1993)
  800. The effect of low dose nitroglycerin on plasma heparin concentrations and activated partial thromboplastin times. (PubMed id 8457649)9 Brack M.J....Gershlick A.H. (amp 1993)
  801. The platelet functions in stroke. (PubMed id 8599071)9 KrajA-ckovA! D....Pecka M. (Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove 1993)
  802. Clinical experience using the Bio-pump for extracorporeal circulation during open-heart surgery. (PubMed id 8338437)9 Yada I....Shimpo H. (Artif Organs 1993)
  803. Alpha granule proteins in type I von Willebrand's disease. (PubMed id 8438875)9 McKeown L.P....Gralnick H.R. (Am. J. Hematol. 1993)
  804. [Alterations of hemostatic markers in elderly patient with atrial fibrillation without a history of stroke]. (PubMed id 8331832)9 Kanda A....Terashi A. (Nihon Ronen Igakkai Zasshi 1993)
  805. Alcohol-induced protein folding transitions in platelet factor 4: the O-state. (PubMed id 8357808)9 Yang Y. and Mayo K.H. (Biochemistry 1993)
  806. [The structural and functional classification and evolution of cytokines]. (PubMed id 7688623)9 Zav'ialov V.P. (Vestn. Akad. Med. Nauk SSSR 1993)
  807. Effect of low molecular weight aliphatic alcohols and related compounds on platelet factor 4 subunit association. (PubMed id 8486623)9 Yang Y....Mayo K.H. (J. Biol. Chem. 1993)
  808. Purification, receptor binding analysis, and biological characterization of human melanoma growth stimulating activity (MGSA). Evidence for a novel MGSA receptor. (PubMed id 8380167)9 Horuk R....Unemori E. (J. Biol. Chem. 1993)
  809. Mode of interaction between platelet factor 4 and heparin. (PubMed id 8358152)9 Maccarana M. and Lindahl U. (Glycobiology 1993)
  810. Iloprost reduces procoagulant activity in the extracorporeal circuit. (PubMed id 7692141)9 Korn R.L....Addonizio V.P. (J. Surg. Res. 1993)
  811. Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth. (PubMed id 1520309)9 Tatakis D.N. (Biochem. Biophys. Res. Commun. 1992)
  812. The melanoma growth stimulatory activity receptor consists of two proteins. Ligand binding results in enhanced tyrosine phosphorylation. (PubMed id 1729365)9 Cheng Q.C....Richmond A. (J. Immunol. 1992)
  813. Ticlopidine and platelet function in healthy volunteers. (PubMed id 1615496)9 Dembinska-Kiec A....Sinzinger H. (Thromb. Res. 1992)
  814. Investigation of how different filters affect some biochemical properties of stored platelet concentrates. (PubMed id 1499695)9 JAoremo P. and Kutti J. (Eur. J. Haematol. 1992)
  815. Interaction between histidine-rich glycoprotein and platelet factor 4 with dermatan sulfate and low-molecular-weight dermatan sulfate. (PubMed id 1554154)9 Cella G....Terribile V.I. (Angiology 1992)
  816. Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers. (PubMed id 1514169)9 Krulder J.W....Meinders A.E. (Thromb. Haemost. 1992)
  817. Racial differences in coagulation studies in stroke. (PubMed id 1355861)9 Gaines K.J....Cape C. (Neurol. Res. 1992)
  818. Modulation of eosinophil chemotaxis by interleukin-5. (PubMed id 1449809)9 Warringa R.A....Koendermann L. (Am. J. Respir. Cell Mol. Biol. 1992)
  819. Anticardiolipin antibodies and coronary heart disease. (PubMed id 1289095)9 Tsakiris D.A....Duckert F. (Eur. Heart J. 1992)
  820. Indobufen versus dipyridamole plus aspirin in the treatment of patients with peripheral atherosclerotic disease. (PubMed id 1512524)9 Fabris F....Girolami A. (J Med 1992)
  821. Spontaneous in vitro megakaryocyte colony formation in primary thrombocythemia: relation to platelet factor 4 plasma level and beta-thromboglobulin/platelet factor 4 ratio. (PubMed id 1386487)9 Abgrall J.F....BriA"re J. (Acta Haematol. 1992)
  822. Association between high levels of growth factors in plasma and progression of coronary atherosclerosis. (PubMed id 1453123)9 Nilsson J....Hamsten A. (J. Intern. Med. 1992)
  823. Circadian variation in platelet function in healthy volunteers. (PubMed id 1532287)9 Jafri S.M....Goldstein S. (Am. J. Cardiol. 1992)
  824. Evidence for a storage pool defect in platelets from cirrhotic patients with defective aggregation. (PubMed id 1386051)9 Laffi G....Nenci G.G. (Gastroenterology 1992)
  825. Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4. (PubMed id 1316786)9 Tunnacliffe A....Poncz M. (Blood 1992)
  826. [Clinical and experimental study of Ligusticum wallichii and aspirin in the treatment of transient ischemic attack]. (PubMed id 1301850)9 Chen D.R. (Zhongguo Zhong Xi Yi Jie He Za Zhi 1992)
  827. Control of angiogenesis by heparin and other sulfated polysaccharides. (PubMed id 1279952)9 Folkman J. and Shing Y. (Adv. Exp. Med. Biol. 1992)
  828. Biological risk factors for sudden death in patients with coronary artery disease and without heart failure. (PubMed id 1563856)9 Lauribe P....Bricaud H. (Int. J. Cardiol. 1992)
  829. Studies on the effect of dopamine on the human platelet response. (PubMed id 1382907)9 Anfossi G....Trovati M. (amp 1992)
  830. Reduced platelet thromboxane formation after long-term administration of a dihydropyridine calcium channel blocker: a prospective, double-blind, placebo-controlled study with nitrendipine in borderline hypertensive patients with IDDM-type diabetes mellitus. (PubMed id 1286547)9 Tschoepe D....Gries F.A. (Diabetes Res. 1992)
  831. Prophylactic antithrombin III administration during pregnancy immediately reduces the thrombin hyperactivity of congenital antithrombin III deficiency by forming thrombin-antithrombin III complexes. (PubMed id 1523607)9 Kario K....Matsuo M. (Thromb. Res. 1992)
  832. Megakaryocytic leukemia and platelet factor 4. (PubMed id 1337850)9 Ryo R....Yamaguchi N. (amp 1992)
  833. [Effect of lovastatin on platelet function in hypercholesterolemic patients]. (PubMed id 1300548)9 DmoszyA+ska A....SokoA8owska B. (Pol. Arch. Med. Wewn. 1992)
  834. Thrombosis in spinal cord injury. (PubMed id 1290164)9 Fujii Y....Weingarden S.T. (Thromb. Res. 1992)
  835. Connective tissue-activating peptide-III and its derivative, neutrophil-activating peptide-2, release histamine from human basophils. (PubMed id 1372016)9 Reddigari S.R....Kaplan A.P. (J. Allergy Clin. Immunol. 1992)
  836. [Atherosclerosis: the risk factors]. (PubMed id 1493667)9 Buschini M....Zenone F. (Clin Ter 1992)
  837. Induction of transient neurological dysfunction in baboons by platelet microemboli. (PubMed id 1533737)9 Kessler C....Harker L.A. ( a journal of cerebral circulation 1992)
  838. Neutralization of the anticoagulant effects of glycosaminoglycans by serum amyloid P component: comparison with other plasma and platelet proteins. (PubMed id 1377216)9 Williams E.C....Asakura S. (J. Lab. Clin. Med. 1992)
  839. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. (PubMed id 1514184)9 Amiral J....Meyer D. (Thromb. Haemost. 1992)
  840. Detection of platelet-specific protein mRNAs in different megakaryoblasts using the reverse transcriptase polymerase chain reaction. (PubMed id 1493450)9 Yasunaga M....Yamaguchi N. (amp 1992)
  841. Interleukin-8, a chemotactic and inflammatory cytokine. (PubMed id 1639201)9 Baggiolini M. and Clark-Lewis I. (FEBS Lett. 1992)
  842. The acute effect of smoking on platelet and endothelial release reaction is suppressed in chronic smokers. (PubMed id 1533735)9 Ozdemir O....Kirazli S. (Thromb. Res. 1992)
  843. Reduction in factor VII, fibrinogen and plasminogen activator inhibitor-1 activity after surgical treatment of morbid obesity. (PubMed id 1448769)9 Primrose J.N....Johnston D. (Thromb. Haemost. 1992)
  844. Markers for endothelial injury, clotting and platelet activation in preeclampsia. (PubMed id 1605673)9 Saleh A.A....Mammen E.F. (Arch. Gynecol. Obstet. 1992)
  845. [A clinical study on hemostatic fluctuation during and after cardiopulmonary bypass using hemostatic molecular markers]. (PubMed id 1336789)9 Nakajima H. (Nihon Kyobu Geka Gakkai Zasshi 1992)
  846. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. (PubMed id 1418604)9 Miller M.D. and Krangel M.S. (Crit. Rev. Immunol. 1992)
  847. Characterization of GRO alpha, beta and gamma expression in human colonic tumours: potential significance of cytokine involvement. (PubMed id 1341267)9 Cuenca R.E....Haskill S. (Surg Oncol 1992)
  848. Platelet activation and vascular damage in gestational hypertension. (PubMed id 1531575)9 Ballegeer V.C....Criel A.M. (Am. J. Obstet. Gynecol. 1992)
  849. Increased levels of tissue plasminogen activator (t-PA) and tissue plasminogen activator inhibitor (PAI) correlate with tumor necrosis factor alpha (TNF alpha)-release in patients suffering from microangiopathy following allogeneic bone marrow transplantation (BMT). (PubMed id 1412203)9 Seeber C....Kolb H.J. (Thromb. Res. 1992)
  850. [Effect of molsidomine infusion on thrombocyte function in acute myocardial infarct]. (PubMed id 1837969)9 Hiller E....Riess H. (Z Kardiol 1991)
  851. Properties of the novel proinflammatory supergene &quot;intercrine&quot; cytokine family. (PubMed id 1910690)9 Oppenheim J.J....Matsushima K. (Annu. Rev. Immunol. 1991)
  852. Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates. (PubMed id 1835678)9 Gruber A....Griffin J.H. (Circulation 1991)
  853. Heparin-releasable platelet factor 4 in patients with coronary artery disease. (PubMed id 1835913)9 Sadayasu T....Kuroiwa A. (Clin Cardiol 1991)
  854. Hemobiological activity of gliclazide in diabetes mellitus. (PubMed id 1794271)9 Ziegler O. and Drouin P. (Diabetes Res. Clin. Pract. 1991)
  855. Platelet function during antihypertensive treatment with quinapril, a novel angiotensin converting enzyme inhibitor. (PubMed id 1708046)9 Gupta R.K....Julius S. (J. Cardiovasc. Pharmacol. 1991)
  856. [Adenine nucleotides in migraine]. (PubMed id 1931099)9 Leira R....Noya M. (Neurologia 1991)
  857. Coagulation disorders and tumor markers in the diagnosis of pancreatic cancer. (PubMed id 1720884)9 Abbasciano V....Zavagli G. (Oncology 1991)
  858. Platelet-derived growth factor mesangial deposits in mesangial IgA glomerulonephritis. (PubMed id 2057110)9 Nakajima M....Kincaid-Smith P. (Nephrol. Dial. Transplant. 1991)
  859. Platelet activation, endothelial cell dysfunction in the absence of anticardiolipin antibodies in systemic sclerosis. (PubMed id 1839040)9 Lima J....PicA^ M. (J. Rheumatol. 1991)
  860. Relationship of platelet specific proteins and other factors to atherosclerosis in various stages of hypertension. (PubMed id 1836985)9 Ding Y.A....Lin K.C. (Clin Exp Hypertens A 1991)
  861. [Effects of Ligusticum wallichii on the plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2 and 6-keto-PGF1 alpha in patients with acute cerebral infarction]. (PubMed id 1840363)9 Liu Z. (Zhong Xi Yi Jie He Za Zhi 1991)
  862. Platelet survival in patients with dilated cardiomyopathy. (PubMed id 1839090)9 Weidinger F....Sinzinger H. (Thromb. Haemost. 1991)
  863. Heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus. (PubMed id 1896971)9 Cella G. and Paolini R. (Thromb. Res. 1991)
  864. The effects of diet and insulin therapy on coagulation factor VII, blood viscosity, and platelet release proteins in diabetic patients with secondary sulphonylurea failure. (PubMed id 1830258)9 Jennings A.M....Ward J.D. (Diabet. Med. 1991)
  865. [Relation of coronary heart disease based on traditional Chinese medicine syndrome differentiation and prostaglandin, blood platelet function, and protein C]. (PubMed id 1831734)9 Guo X.C. (Zhong Xi Yi Jie He Za Zhi 1991)
  866. Storage of platelets in a new plastic container. Polyvinyl chloride plasticized with butyryl-n-trihexyl citrate. (PubMed id 1807058)9 Gulliksson H....UdAcn A.M. (Vox Sang. 1991)
  867. Platelet function and fibrinolytic activity in hypertension: differential effects of calcium antagonists and beta-adrenergic receptor blockers. (PubMed id 1725542)9 Winther K....Hedner T. (J. Cardiovasc. Pharmacol. 1991)
  868. [Thromboxane, prostacyclin and platelet factor 4 in patients with atrial fibrillation]. (PubMed id 1942987)9 Panchenko V.M....Zhivoderov V.M. (Klin Med (Mosk) 1991)
  869. [Anti-heparin activity of plasma with various low density lipoprotein content]. (PubMed id 1669184)9 Worowski K....Skrzydlewski Z. (Pol Tyg Lek 1991)
  870. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). (PubMed id 2012010)9 Qureshi A.A....Peterson D.M. (Am. J. Clin. Nutr. 1991)
  871. [Experimental and clinical study of activated platelet in allergic asthma]. (PubMed id 1806336)9 Yu H.P....Li P.S. (Zhonghua Nei Ke Za Zhi 1991)
  872. Platelet factor 4 mRNA expression in cells from a patient with megakaryoblastic crisis of chronic myelogenous leukemia. (PubMed id 1991266)9 Ryo R....Yokoyama M. (Cancer 1991)
  873. Correlation of aggregometry responses to changes in light transmission through platelet packs. (PubMed id 1891765)9 JAoremo P....Berseus O. (Thromb. Res. 1991)
  874. Neurite outgrowth in dorsal root neuronal hybrid clones modulated by ganglioside GM1 and disintegrins. (PubMed id 1825296)9 Barletta E....Culp L.A. (Exp. Cell Res. 1991)
  875. Alterations of platelet function induced by interleukin-2. (PubMed id 1790144)9 Oleksowicz L....Holland J.F. (J. Immunother. 1991)
  876. Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia. (PubMed id 1877038)9 Wedzicha J.A....Tan K.C. (Thorax 1991)
  877. Hirudin--a potential stabilizing factor for platelet preservation in transfusion. (PubMed id 1832654)9 Pindur G....Braun B. (Haemostasis 1991)
  878. Interleukin 8-inhibitor and inducer of histamine and leukotriene release in human basophils. (PubMed id 1715699)9 Bischoff S.C....Dahinden C.A. (Biochem. Biophys. Res. Commun. 1991)
  879. Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. (PubMed id 1926064)9 Domoto D.T....Joist J.H. (Thromb. Res. 1991)
  880. Effects of taprostene, a stable prostacyclin analogue, on haemodynamics, platelet function and arachidonate metabolism in healthy volunteers. (PubMed id 2111774)9 Virgolini I....Barth H. (Eur. J. Clin. Pharmacol. 1990)
  881. Changes in hemostasis activity during delivery and the immediate postpartum period. (PubMed id 2140236)9 Gerbasi F.R....Mammen E.F. (Am. J. Obstet. Gynecol. 1990)
  882. Dipyridamole specifically decreases platelet-derived growth factor release from platelets. (PubMed id 2150573)9 Takehara K....Ishibashi Y. (Thromb. Res. Suppl. 1990)
  883. Reference values of hemostasis related factors of healthy Japanese adults. I: Circadian fluctuation. (PubMed id 2087689)9 Akiyama Y....Suzuki S. (Thromb. Res. 1990)
  884. [Studies on the intraglomerular distribution of fibronectin in IgA nephropathy--in relation to clinical pictures and prognosis]. (PubMed id 2198363)9 Urae M. (Nihon Jinzo Gakkai Shi 1990)
  885. Global and molecular hemostatic markers in acute myeloid leukemia. (PubMed id 2220667)9 Reddy V.B....Schumacher H.R. (Am. J. Clin. Pathol. 1990)
  886. Hemodynamic, platelet and clinical responses to prostacyclin in unstable angina pectoris. (PubMed id 2109927)9 ThAcroux P....Waters D. (Am. J. Cardiol. 1990)
  887. Regulation of megakaryocyte phenotype in human erythroleukemia cells. (PubMed id 2318965)9 Long M.W....Prochownik E.V. (J. Clin. Invest. 1990)
  888. A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. (PubMed id 2189406)9 Ohmori Y. and Hamilton T.A. (Biochem. Biophys. Res. Commun. 1990)
  889. [Beta-thromboglobulin and platelet factor 4 in a follow-up of acute myelofibrosis (megakaryoblastic leukemia)]. (PubMed id 2146451)9 Palomera Bernal L. and GarcA-a DA-ez I. (Med Clin (Barc) 1990)
  890. Clonal segregation of multiple and overlapping matrix adhesive responses in dorsal root neuronal derivative cells. (PubMed id 2332451)9 Barletta E. and Culp L.A. (J. Cell. Physiol. 1990)
  891. In vitro thromboxane synthesis of depleted blood platelets following renal transplantation. (PubMed id 2148845)9 Scharf R.E. (Thromb. Haemost. 1990)
  892. Thrombin generation is not increased in the blood of hemophilia B patients after the infusion of a purified factor IX concentrate. (PubMed id 2265248)9 Mannucci P.M....Rosenberg R.D. (Blood 1990)
  893. [Hormonal profile and changes in platelet aggregation in menstrual migraine]. (PubMed id 2100130)9 Leira R....Noya M. (Neurologia 1990)
  894. Platelet responses to intravenous infusion of Intralipid in healthy volunteers. (PubMed id 2144940)9 Jarnvig I.L....Wilhjelm B. (Am. J. Clin. Nutr. 1990)
  895. Dose-dependent effects of verapamil and nifedipine on in vivo platelet function in normal volunteers. (PubMed id 2147908)9 Winther K....Hedner T. (Eur. J. Clin. Pharmacol. 1990)
  896. [Disorders of blood platelet homeostasis in patients with multiple myeloma before the treatment and during remission]. (PubMed id 2092326)9 DmoszyA8ska-Giannopoulou A....SokoA8owska B. (Pol. Arch. Med. Wewn. 1990)
  897. Clinical effects of a polyethylene glycol grafted cellulose membrane on thrombogenicity and biocompatibility during hemodialysis. (PubMed id 2252772)9 Akizawa T....Imamura K. (ASAIO Trans 1990)
  898. Beta-TG and plasma catecholamines levels after sympathetic stimuli in hypertensives and patients with peripheral vascular disease. (PubMed id 2144920)9 Catalano M....Libretti A. (Thromb. Haemost. 1990)
  899. Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily. (PubMed id 1967588)9 Modi W.S....O'Brien S.J. (Hum. Genet. 1990)
  900. Sustained-release nifedipine (nifedipine-L) suppresses plasma thromboxane B2 and 6-keto prostaglandin F1 alpha in both young male smokers and nonsmokers. (PubMed id 2353613)9 Nakashima Y....Kuroiwa A. (Am. Heart J. 1990)
  901. Identification of a novel platelet-derived neutrophil-chemotactic polypeptide with structural homology to platelet-factor 4. (PubMed id 2241978)9 SchrAPder J.M....Christophers E. (Biochem. Biophys. Res. Commun. 1990)
  902. Effect of disulfiram on the platelet function and fibrinolysis in healthy volunteers. (PubMed id 1700758)9 Gleerup G....Winther K. (Haemostasis 1990)
  903. [Megakaryocytic leukemia cell lines and megakaryocytic leukemia]. (PubMed id 2381077)9 Ryo R....Yamaguchi N. (Rinsho Byori 1990)

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Entrez Gene: 5196 HGNC: 8861 AceView: PF4 Ensembl:ENSG00000163737 euGenes: HUgn5196
ECgene: PF4 Kegg: 5196 H-InvDB: PF4

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PharmGKB entry for PF4 Pharmacogenomics, SNPs, Pathways
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