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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PF4 Gene

protein-coding   GIFtS: 63
GCID: GC04M074836

Platelet Factor 4

(Previous name: platelet factor 4)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Platelet Factor 41 2     C-X-C Motif Chemokine 42 3
Chemokine (C-X-C Motif) Ligand 41 2     iroplact2
CXCL42 3     oncostatin-A2
PF-42 3     Iroplact3
SCYB42 3     Oncostatin-A3

External Ids:    HGNC: 88611   Entrez Gene: 51962   Ensembl: ENSG000001637377   OMIM: 1734605   UniProtKB: P027763   

Export aliases for PF4 gene to outside databases

Previous GC identifers: GC04M075086 GC04M075247 GC04M075313 GC04M075211 GC04M070658


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PF4 Gene:
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of
activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet
aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of
hematopoiesis, angiogenesis and T-cell function. (provided by RefSeq, Mar 2012)

GeneCards Summary for PF4 Gene: 
PF4 (platelet factor 4) is a protein-coding gene. Diseases associated with PF4 include erythromelalgia, and intermediate coronary syndrome, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds
more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for
neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor
than the longer form

Gene Wiki entry for PF4 (Platelet factor 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PF4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q21

PF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PF4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074836:  view genomic region     (about GC identifiers)

Start:
74,846,794 bp from pter      End:
74,847,841 bp from pter
Size:
1,048 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776 (See protein sequence)
Recommended Name: Platelet factor 4 precursor  
Size: 101 amino acids; 10845 Da
Subunit: Homotetramer
Subcellular location: Secreted
Mass spectrometry: Mass=7765; Method=Electrospray; Range=32-101; Source=PubMed:7644496;
Mass spectrometry: Mass=6033; Method=Electrospray; Range=48-101; Note=Short form; Source=PubMed:7644496;
6/7 PDB 3D structures from and Proteopedia for PF4 (see all 7):
1DN3 (3D)        1F9Q (3D)        1F9R (3D)        1F9S (3D)        1PFM (3D)        1PFN (3D)    
Secondary accessions: Q53X61 Q9UC64 Q9UC65

Explore the universe of human proteins at neXtProt for PF4: NX_P02776

Explore proteomics data for PF4 at MOPED 

PF4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

PF4 Protein Expression

REFSEQ proteins: NP_002610.1  
ENSEMBL proteins: 
 ENSP00000296029  
Reactome Protein details: P02776
Human Recombinant Protein Products for PF4: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for PF4 (CXCL4/PF4)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for PF4
OriGene Protein Over-expression Lysate for PF4
OriGene MassSpec for PF4 
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GenScript Purified and Recombinant Proteins for PF4
Novus Biologicals PF4 Proteins
Novus Biologicals PF4 Lysates
Sino Biological Recombinant Protein for PF4
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for PF4
Cloud-Clone Corp. Proteins for PF4 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0031093platelet alpha granule lumen TAS--

PF4 for ontologies           About GeneDecksing



PF4 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for PF4 

Assay Products for PF4: 
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R&D Systems ELISAs for PF4 (CXCL4/PF4)         (see all)
GenScript Custom Assay Services for PF4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for PF4 
Cloud-Clone Corp. CLIAs for PF4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR027222 PF4
 IPR001811 Chemokine_IL8-like_dom
 IPR001089 Chemokine_CXC
 IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P02776

ProtoNet protein and cluster: P02776

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
Similarity: Belongs to the intercrine alpha (chemokine CxC) family


PF4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PLF4_HUMAN, P02776
Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds
more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for
neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor
than the longer form

     Genatlas biochemistry entry for PF4:
platelet factor 4 (see IMC2@)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity TAS12466273
GO:0008201heparin binding IDA9531587
     
PF4 for ontologies           About GeneDecksing


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pf4):
 hematopoietic system  homeostasis/metabolism 

PF4 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Pf4tm1Mako for PF4

   inGenious Targeting Laboratory - Custom generated mouse model solutions for PF4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PF4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PF4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PF4 

miRNA
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Inhib. RNA
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Gene Editing
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Clone
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OriGene ORF clones in mouse, rat for PF4
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GenScript: all cDNA clones in your preferred vector: PF4 (NM_002619)
Sino Biological Human cDNA Clone for PF4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PF4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PF4
Sirion Biotech Customized lentivirus for stable overexpression of PF4 
                     Customized lentivirus expression plasmids for stable overexpression of PF4 

Cell Line
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Search LifeMap BioReagents cell lines for PF4
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PF4 About   (see all 12)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
IL-6 Pathway0.61
MIF Regulation of Innate Immune Cells0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Chemokine Signaling
Chemokine Signaling0.33
Chemokine signaling pathway0.33
3Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.46
4Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
5Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PF4 (see all 17)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Transendothelial Migration of Leukocytes
MIF Mediated Glucocorticoid Regulation

1 BioSystems Pathway for PF4
    CXCR3-mediated signaling events


5/12        Reactome Pathways for PF4 (see all 12)
    GPCR downstream signaling
Hemostasis
Peptide ligand-binding receptors
Signaling by GPCR
GPCR ligand binding


2         Kegg Pathways  (Kegg details for PF4):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway


PF4 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/71 Interacting proteins for PF4 (P027762, 3 ENSP000002960294) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
InteractantInteraction Details
GeneCardExternal ID(s)
IL8P101453, ENSP000003065124I2D: score=3 STRING: ENSP00000306512
PROCP040703, ENSP000002340714I2D: score=2 STRING: ENSP00000234071
SRGNP101243, ENSP000002424654I2D: score=2 STRING: ENSP00000242465
CXCL12P480613, ENSP000003635484I2D: score=1 STRING: ENSP00000363548
CCL5P135013, ENSP000002932724I2D: score=2 STRING: ENSP00000293272
About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002576platelet degranulation TAS--
GO:0006955immune response IEA--
GO:0007596blood coagulation TAS--
GO:0010628positive regulation of gene expression IDA10666185
GO:0010744positive regulation of macrophage derived foam cell differentiation IDA17244792

PF4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PF4 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PF4 (PLF4)

1 DrugBank Compound for PF4    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Drotrecogin alfaAnticoagulant protein C (see all 4)60202-16-6target--11259926

10/114 Novoseek inferred chemical compound relationships for PF4 gene (see all 114)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
heparin 87.7 940 8282825 (7), 17257993 (6), 8857955 (6), 1537108 (6) (see all 99)
danaparoid 84.1 2 18983520 (1), 16109780 (1)
hirudin 80.3 7 16404704 (1), 9024148 (1), 18541684 (1), 1832654 (1) (see all 5)
fibrinopeptide a 75.6 11 7646626 (2), 7539015 (2), 7637955 (1), 1720884 (1) (see all 6)
txb2 75.1 95 8329704 (5), 1840363 (3), 10475099 (3), 15613179 (2) (see all 46)
fondaparinux 72.6 12 18262226 (3), 9518042 (1), 15317404 (1), 16359523 (1) (see all 10)
rantes 68.4 87 15459010 (9), 15899984 (5), 19201759 (3), 7531729 (3) (see all 38)
fibrinogen 67.9 72 17351162 (3), 8996302 (2), 11077138 (2), 7553675 (2) (see all 50)
tecogalan sodium 65.4 2 9409948 (1), 10439927 (1)
adp 65.1 49 7843648 (3), 12889011 (3), 9863147 (2), 11782701 (2) (see all 30)

Search CenterWatch for drugs/clinical trials and news about PF4 / PLF4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PF4 gene: 
NM_002619.3  

Unigene Cluster for PF4:

Platelet factor 4
Hs.81564  [show with all ESTs]
Unigene Representative Sequence: NM_002619
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000296029(uc003hhi.2)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PF4

Additional mRNA sequence: 

BC093965.1 BC112093.1 CR407677.1 M25897.1 

2 DOTS entries:

DT.113152  DT.121223983 

24/30 AceView cDNA sequences (see all 30):

CR407677 AI078445 BQ023965 BX114245 AI739539 AJ705588 NM_002619 T28407 
T84282 N92470 M25897 AA152486 AA024823 AI185569 BV177626 CA426108 
AA024929 AI766542 T85166 W17158 AI400188 AA152485 AI470327 R83715 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PF4 expression in normal human tissues (normalized intensities)      PF4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PF4 Expression
About this image


PF4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/10 selected tissues (see all 10) fully expand
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
         Cranial Neural Crest Cells Branchial Arch 1
         mesenchyme   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Mesenchymal Condensate Cells Zeugopod
         Bone Marrow
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Medulla Oblongata
 
 Mesoderm (Gastrulation Derivatives)
         mesenchyme   

See PF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PF4

SOURCE GeneReport for Unigene cluster: Hs.81564
    SABiosciences Expression via Pathway-Focused PCR Arrays including PF4 (see all 8): 
          Endothelial Cell Biology in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Angiogenesis in human mouse rat

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PF4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PF4 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pf41 , 5 platelet factor 41, 5 75.91(n)1
72.28(a)1
  5 (44.78 cM)5
567441  NM_019932.41  NP_064316.11 
 907724355 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
29(a)
possible ortholog
4(50379773-50381069)
lizard
(Anolis carolinensis)
Reptilia --
--
30(a)
possible ortholog
6(60123888-60134622)


ENSEMBL Gene Tree for PF4 (if available)
TreeFam Gene Tree for PF4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PF4 gene
PPBP2  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
9 SIMAP similar genes for PF4 using alignment to 1 protein entry:     PLF4_HUMAN:
PF4V1    PPBP    CXCL5    CXCL10    CXCL6    CXCL1
CXCL2    IL8    CXCL3

PF4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/121 SNPs in PF4 are shown (see all 121)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1478434171,2
--74724385(+) CCAACA/GTATTC 1 -- ds50010--------
rs1116657401,2
C,F--74724455(+) GAGATG/ATGACA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs1839965631,2
--74724474(+) AGAGGC/TTGGAG 1 -- ds50010--------
rs1887704001,2
--74724524(+) AGAACA/GTAGAT 1 -- ds50010--------
rs1502871851,2
--74724631(+) CCCACC/TTGGGA 1 -- ds50010--------
rs1124443471,2
C--74724797(+) AAAAA-/CATCATCA 1 -- cds11Minor allele frequency- CAT:0.50CSA 2
rs3520041,2
C,F,O,H--74724908(-) TATTAC/TCTTTG 1 -- ut3126Minor allele frequency- T:0.12MN NS EA NA WA CSA 2514
rs1448896531,2
--74724938(+) TGTAGA/CTATAA 1 -- ut310--------
rs3520051,2
C,F,O,H--74724966(-) ATTCAT/CGCATT 1 -- ut3114Minor allele frequency- C:0.09MN NA NS EA WA 912
rs115744521,2
C,F,H--74724999(-) GTTATG/TCTTGG 1 -- ut3119Minor allele frequency- T:0.07NA NS EA 2466

HapMap Linkage Disequilibrium report for PF4 (74846794 - 74847841 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PF4:    About this table     
Variant IDTypeSubtypePubMed ID
nsv525980CNV Gain19592680

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing PF4
DNA2.0 Custom Variant and Variant Library Synthesis for PF4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 173460    OMIM disorders: --

20/123 diseases for PF4 (see all 123):    About MalaCards
erythromelalgia    intermediate coronary syndrome    sneddon syndrome    acute poststreptococcal glomerulonephritis
heparin-induced thrombocytopenia    essential thrombocythemia    megakaryocytic leukemia    arteriosclerosis obliterans
iga glomerulonephritis    intermittent claudication    polycythemia vera    arteriosclerosis
uremia    corneal neovascularization    thrombasthenia    glanzmann's thrombasthenia
polycythemia    cerebral infarction    headache    peripheral vascular disease

4 diseases from the University of Copenhagen DISEASES database for PF4:
Thrombocytopenia     Vascular disease     Heart disease     Myeloma

PF4 for disorders           About GeneDecksing

10/94 Novoseek inferred disease relationships for PF4 gene (see all 94)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thrombocytopenia 85.4 191 8282825 (3), 12753876 (3), 17495129 (3), 10938877 (2) (see all 99)
thrombosis 75.6 75 14764524 (3), 20004006 (3), 9002937 (3), 8282825 (2) (see all 38)
abnormal platelets 61.3 2 2141791 (1), 1931099 (1)
thromboembolism 60.5 6 11827497 (1), 11442479 (1), 19521017 (1)
megakaryoblastic leukemia acute 60.5 2 1337850 (1), 1493450 (1)
thrombocytosis 59.9 10 2140694 (2), 1826402 (1), 10086090 (1), 16462666 (1) (see all 6)
thrombophilia 58.4 2 11342462 (1), 16766786 (1)
thrombocythemia essential 51.3 4 1386487 (1), 16138352 (1), 15352995 (1), 16977569 (1)
platelet aggregation, spontaneous 48.8 3 1692679 (1), 8870174 (1)
erythromelalgia 46.9 5 16138352 (2), 12781799 (1), 8883266 (1)

Genetic Association Database (GAD): PF4
Human Genome Epidemiology (HuGE) Navigator: PF4 (10 documents)

Export disorders for PF4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PF4 gene, integrated from 9 sources (see all 915) (see top 10):
(articles sorted by number of sources associating them with PF4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)1, 2, 9 Eisman R.... Poncz M. (1990)
  2. Localization of distal regulatory domains in the megakaryocyte- specific platelet basic protein/platelet factor 4 gene locus. (PubMed id 11468158)1, 2, 9 Zhang C.... Reilly M.P. (2001)
  3. NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. (PubMed id 7547867)1, 2, 9 Mayo K.H....Daly T.J. (1995)
  4. Crystal structure of recombinant human platelet factor 4. (PubMed id 8031770)1, 2, 9 Zhang X.... Maione T.E. (1994)
  5. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
  9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  11. Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. (PubMed id 3098319)1, 2 Poncz M.... Schwartz E. (1987)
  12. Human platelet factor 4 gene is mapped to 4q12----q21. (PubMed id 3622011)1, 3 Griffin C.A....Poncz M. (1987)
  13. Complete covalent structure of human platelet factor 4. (PubMed id 6445090)1, 2 Morgan F.J.... Chesterman C.N. (1980)
  14. Isolation, crystallization, and primary amino acid sequence of human platelet factor 4. (PubMed id 893407)1, 2 Hermodson M.... Kurachi K. (1977)
  15. Primary structure of human platelet factor 4. (PubMed id 601757)1, 2 Walz D.A.... McCoy L.E. (1977)
  16. Amino acid sequence of human platelet factor 4. (PubMed id 267922)1, 2 Deuel T.F.... Heinrikson R.L. (1977)
  17. Negative regulation of human megakaryocytopoiesis by human platelet factor 4 and beta thromboglobulin: comparative analysis in bone marrow cultures from normal individuals and patients with essential thrombocythaemia and immune thrombocytopenic purpura. (PubMed id 2140694)1, 9 Han Z.C....Caen J.P. (1990)
  18. Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C. (PubMed id 9395524)1, 9 Dudek A.Z....Slungaard A. (1997)
  19. Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. (PubMed id 15459010)1, 9 von Hundelshausen P....Weber C. (2005)
  20. Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis. (PubMed id 12586630)1, 9 Dudek A.Z....Slungaard A. (2003)
  21. Platelet factor 4 is highly upregulated in dendritic cells after severe trauma. (PubMed id 19750196)1, 9 Maier M....Marzi I. (2009)
  22. Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin. (PubMed id 17090548)1, 9 Amelot A.A....Le Bonniec B.F. (2007)
  23. Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface. (PubMed id 11986215)1, 9 Sachais B.S....Higazi A.A. (2002)
  24. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. (PubMed id 16304054)1, 9 Rauova L....Poncz M. (2006)
  25. The control of angiogenesis and tumor invasion by platelet factor-4 and platelet factor-4-derived molecules. (PubMed id 15034805)1, 9 Bikfalvi A. and Gimenez-Gallego G. (2004)
  26. Elevated Platelet Activation in Patients with Atopic Dermatitis and Psoriasis: Increased Plasma Levels of beta-Thromboglobulin and Platelet Factor 4. (PubMed id 18797178)1, 9 Tamagawa-Mineoka R....Kishimoto S. (2008)
  27. Immune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion. (PubMed id 18539895)1, 9 Xiao Z....Neelamegham S. (2008)
  28. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. (PubMed id 15304392)1, 9 Rauova L....Sachais B.S. (2005)
  29. Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms. (PubMed id 15291808)1, 9 Sulpice E....Tobelem G. (2004)
  30. Upstream stimulatory factors stimulate transcription through E-box motifs in the PF4 gene in megakaryocytes. (PubMed id 15187018)1, 9 Okada Y....Doi T. (2004)
  31. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. (PubMed id 12609838)1, 9 Slungaard A....Lentz S.R. (2003)
  32. Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. (PubMed id 14652645)1, 9 Pitsilos S....Sachais B.S. (2003)
  33. Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells. (PubMed id 12466273)1, 9 Nassar T....Higazi A.A. (2003)
  34. Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8. (PubMed id 12223528)1, 9 Marti F....Rueda F. (2002)
  35. Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. (PubMed id 11830470)1, 9 Li Z.Q....Poncz M. (2002)
  36. A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4. (PubMed id 7644496)2, 9 Gupta S.K.... Singh J.P. (1995)
  37. Platelet-associated PF-4 as a biomarker of early tumor growth. (PubMed id 17914028)1, 9 Cervi D....Klement G.L. (2008)
  38. Evidence for a granule targeting sequence within platelet factor 4. (PubMed id 15964840)1, 9 El Golli N....Briquet-Laugier V. (2005)
  39. Platelet factor 4 (PF-4)-induced neutrophil adhesion is controlled by src-kinases, whereas PF-4-mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase. (PubMed id 14592823)1, 9 Kasper B....Petersen F. (2004)
  40. The role of platelet factor 4 in platelet aggregation induced by the antibodies implicated in heparin-induced thrombocytopenia. (PubMed id 11685038)1, 9 Gerotziafas G.T....Samama M.M. (2001)
  41. Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor. (PubMed id 7524669)1, 9 Brown K.J. and Parish C.R. (1994)
  42. Increased platelet activity in patients with isolated coronary artery ectasia. (PubMed id 17700216)1, 9 Yasar A.S....Sabah I. (2007)
  43. Platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients. (PubMed id 15265941)1, 9 Pervushina O....Petersen F. (2004)
  44. Platelet-derived chemokines CXC chemokine ligand (CXCL)7, connective tissue-activating peptide III, and CXCL4 differentially affect and cross-regulate neutrophil adhesion and transendothelial migration. (PubMed id 12193731)1, 9 Schenk B.I....Brandt E. (2002)
  45. Mediators of neutrophil recruitment in human abdominal aortic aneurysms. (PubMed id 19201759)1, 9 Houard X....Michel J.B. (2009)
  46. Increased concentration of platelet-derived chemokines in serum of patients with delayed pressure urticaria. (PubMed id 18632422)1, 9 Kasperska-Zajac A....Rogala B. (2008)
  47. The effect of secreted heparin-binding proteins on heparin binding to platelets. (PubMed id 8511754)1, 9 Horne M.K. (1993)
  48. Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G. (PubMed id 16317101)1, 9 Schiemann F....Brandt E. (2006)
  49. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PubMed id 12782716)1, 9 Lasagni L.... Romagnani P. (2003)
  50. {beta}2 Glycoprotein I ({beta}2GPI) binds platelet fa ctor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome. (PubMed id 19805618)1, 9 Sikara M.P....Vlachoyiannopoulos P.G. (2010)
  51. Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level. (PubMed id 15531763)1, 9 Nesmelova I.V....Mayo K.H. (2005)
  52. Platelet factor 4 differentially modulates CD4+CD25+ (regulatory) versus CD4+CD25- (nonregulatory) T cells. (PubMed id 15728475)1, 9 Liu C.Y....Visentin G.P. (2005)
  53. Diabetes mellitus: a hypercoagulable state. (PubMed id 11259926)7, 9 Carr M.E. (2001)
  54. Serglycin-binding proteins in activated macrophages and platelets. (PubMed id 8613703)1, 9 Kolset S.O....Ruoslahti E. (1996)
  55. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. (PubMed id 1688470)1, 9 Maione T.E....Sharpe R.J. (1990)
  56. Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in reti nal endothelial cells and are enhanced in diabetic retinopathy. (PubMed id 23352833)1 Nawaz M.I....Struyf S. (2013)
  57. Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1. (PubMed id 23536183)2 Kuo J.H.... Sue S.C. (2013)
  58. Anti-PF4/heparin antibodies and venous graft occlusion in postcoronary artery bypass surgery patients randomized to postoperative unfr actionated heparin or fondaparinux thromboprophylaxis. (PubMed id 23216710)1 Warkentin T.E....Eikelboom J.W. (2013)
  59. Platelet activation suppresses HIV-1 infection of T ce lls. (PubMed id 23634812)1 Solomon Tsegaye T....Pohlmann S. (2013)
  60. Identification of the platelet-derived chemokine CXCL4 /PF-4 as a broad-spectrum HIV-1 inhibitor. (PubMed id 22645343)1 Auerbach D.J....Lusso P. (2012)
  61. Platelet factor 4 and Duffy antigen required for plate let killing of Plasmodium falciparum. (PubMed id 23224555)1 McMorran B.J....Foote S.J. (2012)
  62. Binding of heparin-dependent antibodies to PF4 modifie d by enoxaparin oligosaccharides: evaluation by surface plasmon resonance and se rotonin release assay. (PubMed id 22235911)1 Leroux D....Pouplard C. (2012)
  63. Genetic variants in platelet factor 4 modulate inflamm atory and platelet activation biomarkers. (PubMed id 22763266)1 Bhatnagar P....Fletcher C.A. (2012)
  64. Clinical evaluation of acute systemic reaction and det ection of IgG antibodies against PF4/heparin complexes in hemodialysis patients. (PubMed id 22088491)1 Matsuo T....Walenga J.M. (2012)
  65. Disruption of PF4/H multimolecular complex formation w ith a minimally anticoagulant heparin (ODSH). (PubMed id 22318669)1 Joglekar M.V....Arepally G.M. (2012)
  66. Dynamic antibody-binding properties in the pathogenesi s of HIT. (PubMed id 22577175)1 Sachais B.S....Cines D.B. (2012)
  67. CXCL4-platelet factor 4, heparin-induced thrombocytope nia and cancer. (PubMed id 22682144)1 Sandset P.M. (2012)
  68. Proteomic analysis reveals platelet factor 4 and beta- thromboglobulin as prognostic markers in severe acute respiratory syndrome. (PubMed id 22740477)1 Poon T.C....Lo Y.M. (2012)
  69. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
  70. Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (2012)
  71. VEGF, PF4 and PDGF are elevated in platelets of colore ctal cancer patients. (PubMed id 22402885)1 Peterson J.E....Folkman J. (2012)
  72. CXC chemokine ligand 4 (CXCL4) down-regulates CC chemo kine receptor expression on human monocytes. (PubMed id 21088050)1 Schwartzkopff F....Brandt E. (2012)
  73. Platelet factor 4 inhibits thrombomodulin-dependent a ctivation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin. (PubMed id 21041299)1 Mosnier L.O. (2011)
  74. Multiple ETS family proteins regulate PF4 gene express ion by binding to the same ETS binding site. (PubMed id 21931859)1 Okada Y....Doi T. (2011)
  75. Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4. (PubMed id 21129147)1 Aneja K....Rao A.K. (2011)
  76. Platelet factor-4 and its p17-70 peptide inhibit myel oma proliferation and angiogenesis in vivo. (PubMed id 21693026)1 Yang L....Zou J. (2011)
  77. The role of the CXC chemokines platelet factor-4 (CXC L4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and ca ncer. (PubMed id 21111666)1 Vandercappellen J....Struyf S. (2011)
  78. CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment. (PubMed id 20961394)1 Sarabi A....Von Hundelshausen P. (2011)
  79. CXCL4 and CXCL10 predict risk of fatal cerebral malar ia. (PubMed id 21508508)1 Wilson N.O....Stiles J.K. (2011)
  80. Functional divergence between 2 chemokines is conferr ed by single amino acid change. (PubMed id 20688960)1 Dubrac A....Prats H. (2010)
  81. Heparin-induced thrombocytopenia: towards standardiza tion of platelet factor 4/heparin antigen tests. (PubMed id 20626620)1 Greinacher A....Warkentin T.E. (2010)
  82. Heparin-platelet factor 4 antibodies in intensive car e patients: an observational seroprevalence study. (PubMed id 19911252)1 Levine R.L....Hursting M.J. (2010)
  83. Antibodies to platelet factor 4-heparin complex and o utcome in hemodialysis patients with diabetes. (PubMed id 20185595)1 Krane V....Wanner C. (2010)
  84. Prevalence of the antiheparin-platelet factor 4 antib ody in hemodialysis (HD) patients and its effects upon dialysis access. (PubMed id 20979952)1 Wallace K....Parry R. (2010)
  85. Anti-PF4/heparin antibody formation postorthopedic su rgery thromboprophylaxis: the role of non-drug risk factors and evidence for a stoichiometry-based model of immunization. (PubMed id 20050998)1 Warkentin T.E....Greinacher A. (2010)
  86. CXCL4 downregulates the atheroprotective hemoglobin r eceptor CD163 in human macrophages. (PubMed id 19910578)1 Gleissner C.A....Ley K. (2010)
  87. Differential changes in platelet VEGF, Tsp, CXCL12, a nd CXCL4 in patients with metastatic cancer. (PubMed id 20182908)1 Wiesner T....Kopp H.G. (2010)
  88. CXCL4-induced monocyte survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1. (PubMed id 20104488)1 Kasper B....Petersen F. (2010)
  89. Evaluation of a new automated panel of assays for the detection of anti-PF4/heparin antibodies in patients suspected of having hepar in-induced thrombocytopenia. (PubMed id 20539902)1 Legnani C....Palareti G. (2010)
  90. Platelet factor 4 (CXCL4) facilitates human macrophag e infection with HIV-1 and potentiates virus replication. (PubMed id 19773294)1 Schwartzkopff F....Clouse K.A. (2009)
  91. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  92. New insights into the molecular interaction of the C-terminal sequence of CXCL4 with fibroblast growth factor-2. (PubMed id 19245795)1 Ragona L....Bikfalvi A. (2009)
  93. The transcriptome of human CD34+ hematopoietic stem-p rogenitor cells. (PubMed id 19416867)1 Kim Y.C....Wang S.M. (2009)
  94. Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancer. (PubMed id 19470732)1 Fiedler G.M....Thiery J. (2009)
  95. Clinical relevance of heparin-PF4 complex antibody in DVT after total joint replacement. (PubMed id 19397833)1 Torigoshi T....Migita K. (2009)
  96. The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4. (PubMed id 19625657)1 Schiemann F....Petersen F. (2009)
  97. The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis. (PubMed id 18648521)1 Aidoudi S....Bikfalvi A. (2008)
  98. Platelet factor-4 is an indicator of blood count recovery in acute myeloid leukemia patients in complete remission. (PubMed id 17998245)1 Kim J.Y....Lee S.W. (2008)
  99. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
  100. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (2008)
  101. Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results. (PubMed id 18369708)1 Arepally G.M. and Hursting M.J. (2008)
  102. 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4. (PubMed id 17077331)1 Cheng S.H....Ng H.K. (2007)
  103. Induction of dendritic cell-like phenotype in macrophages during foam cell formation. (PubMed id 17244792)1 Cho H.J....Ley K. (2007)
  104. Synovial angiostatic non-ELR CXC chemokines in inflammatory arthritides: does CXCL4 designate chronicity of synovitis? (PubMed id 17265155)1 Erdem H....Sengul A. (2007)
  105. CXCL4 in atherosclerosis: possible roles in monocyte arrest and macrophage foam cell formation. (PubMed id 18000592)1 Gleissner C.A. and Ley K. (2007)
  106. Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease. (PubMed id 17220270)1 Aivado M....Libermann T.A. (2007)
  107. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)
  108. Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells. (PubMed id 17827342)1 Vandercappellen J....Struyf S. (2007)
  109. PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. (PubMed id 17218382)1 Lasagni L....Romagnani P. (2007)
  110. Platelet factor 4 (CXC chemokine ligand 4) differentially regulates respiratory burst, survival, and cytokine expression of human monocytes by using distinct signaling pathways. (PubMed id 17675521)1 Kasper B....Petersen F. (2007)
  111. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PubMed id 16806233)1 Ma J....Liew C.C. (2007)
  112. Incidence of antiheparin-platelet factor 4 antibodies and heparin-induced thrombocytopenia in Turkish patients undergoing cardiac surgery. (PubMed id 17636189)1 Demir M....Fareed J. (2007)
  113. Live attenuated Salmonella carrying platelet factor 4 cDNAs as radioprotectors. (PubMed id 16881736)1 Liu B....Han Z.C. (2006)
  114. Roles of platelet factor 4 in hematopoiesis and angiogenesis. (PubMed id 17381065)1 Maurer A.M....Han Z.C. (2006)
  115. Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner. (PubMed id 15591119)1 Yu G....Sachais B.S. (2005)
  116. Regulated expression of platelet factor 4 in human monocytes--role of PARs as a quantitatively important monocyte activation pathway. (PubMed id 15788441)1 Schaffner A....Schaer D.J. (2005)
  117. Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN. (PubMed id 15994292)1 Gao P....Howard O.M. (2005)
  118. The human plasma proteome: a nonredundant list developed by combination of four separate sources. (PubMed id 14718574)1 Anderson N.L....Lobley A. (2004)
  119. PREP1, MEIS1 homolog protein, regulates PF4 gene expression. (PubMed id 12732210)1 Okada Y....Doi T. (2003)
  120. Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide. (PubMed id 14575696)1 Fiore M.M. and Kakkar V.V. (2003)
  121. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. (PubMed id 12878486)1 Ma J. and Liew C.C. (2003)
  122. Platelet factor 4 inhibits proliferation and cytokine release of activated human T cells. (PubMed id 12097379)1 Fleischer J....Petersen F. (2002)
  123. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  124. Signal transduction of chemokine platelet factor 4 in human erythroleukemia cells. (PubMed id 12041672)1 Liu Y.J....Han Z.C. (2002)
  125. Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway. (PubMed id 12384403)1 Sulpice E....Tobelem G. (2002)
  126. Versican interacts with chemokines and modulates cellular responses. (PubMed id 11083865)1 Hirose J....Miyasaka M. (2001)
  127. The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. (PubMed id 10666185)1 Scheuerer B....Petersen F. (2000)
  128. Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha. (PubMed id 10233851)1 Salcedo R....Oppenheim J.J. (1999)
  129. Heparin dodecasaccharide binding to platelet factor-4 and growth-related protein-alpha. Induction of a partially folded state and implications for heparin-induced thrombocytopenia. (PubMed id 10464257)1 Mikhailov D....Mayo K.H. (1999)
  130. Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization. (PubMed id 9558385)1 Perollet C....Bikfalvi A. (1998)
  131. New insights into the negative regulation of hematopoiesis by chemokine platelet factor 4 and related peptides. (PubMed id 9531587)1 Lecomte-Raclet L....Han Z.C. (1998)
  132. [Bioassay of recombinant human platelet factor 4] (PubMed id 15622770)1 Han Z....Han Z. (1997)
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  285. Heparin-induced thrombocytopenia: a stoichiometry-based model to explain the differing immunogenicities of unfractionated heparin, low-molecular-weight heparin, and fondaparinux in different clinical settings. (PubMed id 18262226)9 Greinacher A....Warkentin T.E. (2008)
  286. Formation of anti-platelet factor 4/heparin antibodie s after cardiac surgery: influence of perioperative platelet activation, the in flammatory response, and histocompatibility leukocyte antigen status. (PubMed id 19114189)9 Paparella D....Warkentin T.E. (2008)
  287. Rivaroxaban--an oral, direct Factor Xa inhibitor--has potential for the management of patients with heparin-induced thrombocytopenia. (PubMed id 18671707)9 Walenga J.M....Bakhos M. (2008)
  288. Enoxaparin but not unfractionated heparin causes a do se-dependent increase in plasma TGF-beta 1 during haemodialysis: a cross-over s tudy. (PubMed id 17389624)9 Naumnik B....Mysliwiec M. (2007)
  289. Predictors for the development of elevated anti-heparin/platelet factor 4 antibody titers in patients undergoing cardiac catheterization. (PubMed id 16860036)9 Yeh R.W....Jang I.K. (2006)
  290. Platelet activation in allergic asthma patients during allergen challenge with Dermatophagoides pteronyssinus. (PubMed id 16630146)9 Kowal K....Bodzenta-A8ukaszyk A. (2006)
  291. Prothrombotic factors enhance heparin-induced thrombo cytopenia and thrombosis in vivo in a mouse model. (PubMed id 16961586)9 Reilly M.P....McKenzie S.E. (2006)
  292. Platelet-mediated erythromelalgic, cerebral, ocular and coronary microvascular ischemic and thrombotic manifestations in patients with essential thrombocythemia and polycythemia vera: a distinct aspirin-responsive and coumadin-resistant arterial thrombophilia. (PubMed id 17127481)9 Michiels J.J....van Vliet H.H. (2006)
  293. Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies. (PubMed id 16873726)9 Greinacher A....Helm C.A. (2006)
  294. Plasma markers of platelet and polymorphonuclear leukocyte activation in young adults with acute myocardial infarction. (PubMed id 15665428)9 Caimi G....Lo Presti R. (2005)
  295. Unfractionated heparin compared with low-molecular-weight heparin as related to heparin-induced thrombocytopenia. (PubMed id 16093810)9 Walenga J.M....Bakhos M. (2005)
  296. Platelet function and fibrinolytic activity in patients with bronchial asthma. (PubMed id 15678276)9 Tutluoglu B....Ulutin T. (2005)
  297. Beta thromboglobulin and platelet factor 4 in bronchoalveolar lavage fluid of patients with systemic sclerosis. (PubMed id 15708900)9 Kowal-Bielecka O....Sierakowski S. (2005)
  298. Recombinant platelet factor 4 for heparin neutralizat ion. (PubMed id 15282660)9 Mixon T.A. and Dehmer G.J. (2004)
  299. Increased blood coagulation and platelet activation in patients with infective endocarditis and embolic events. (PubMed id 15049384)9 BuyukasA1k N.S....Demirkan D. (2004)
  300. Exposure of fibrinogen-adherent platelets to plasma proteins: a new method for studying protein interactions with platelets. (PubMed id 12889011)9 Broberg M. and Nygren H. (2003)
  301. Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis. (PubMed id 14987915)9 Horigome H....Matsui A. (2003)
  302. Enhanced release of platelet factor 4 into the circulation in patients with atopic eczema/dermatitis syndrome. (PubMed id 14737958)9 Kasperska-Zajac A....Nowakowski M. (2003)
  303. Lipolysis generates platelet dysfunction after in vivo heparin administration. (PubMed id 12241544)9 Muriithi E.W....Wheatley D.J. (2002)
  304. [Some parameters of platelet activation in patients with uremia before and after hemodialysis (HD)] (PubMed id 12731371)9 Dymicka-Piekarska V....Piszka J. (2002)
  305. Platelet concentrates derived from buffy coat and apheresis: biochemical and functional differences. (PubMed id 12383338)9 BAPck M....Heim M.U. (2002)
  306. Standard heparin versus low-molecular-weight heparin. A medium-term comparison in hemodialysis. (PubMed id 12372942)9 Stefoni S....D'Addio F. (2002)
  307. Aortic spontaneous echocardiographic contrast and hemostatic markers in patients with nonrheumatic atrial fibrillation. (PubMed id 11834664)9 Nakagawa K....Inoue H. (2002)
  308. Heparin-induced thrombocytopenia: molecular pathogenesis. (PubMed id 12430880)9 Lee S.H....PaoloVisentin G. (2002)
  309. Beta-thromboglobulin and platelet factor 4 levels in post-myocardial infarction patients with major depression. (PubMed id 11927146)9 Kuijpers P.M....Honig A. (2002)
  310. Direct thrombin inhibitors. (PubMed id 12356489)9 Weitz J.I. and Crowther M. (2002)
  311. Insights from mouse models of heparin-induced thrombocytopenia and thrombosis. (PubMed id 12172457)9 Reilly M.P. and McKenzie S.E. (2002)
  312. Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. (PubMed id 11342433)9 Majka M....Ratajczak M.Z. (2001)
  313. Thrombogenesis in sickle cell disease. (PubMed id 11385360)9 Tomer A....Eckman J.R. (2001)
  314. Validation of blood collection procedures for the det ermination of circulating vascular endothelial growth factor (VEGF) in differen t blood compartments. (PubMed id 11471901)9 Dittadi R....Gion M. (2001)
  315. Heparin-induced thrombocytopenia: natural history, diagnosis, and management. (PubMed id 11530963)9 Deitcher S.R. and Carman T.L. (2001)
  316. Heparin is not required for detection of antibodies a ssociated with heparin-induced thrombocytopenia/thrombosis. (PubMed id 11433225)9 Visentin G.P....Aster R.H. (2001)
  317. Designed beta-sheet peptides that inhibit proliferation and induce apoptosis in endothelial cells. (PubMed id 11824378)9 Mayo K.H....Griffioen A.W. (2001)
  318. Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4. (PubMed id 11462931)9 Panasiuk A....Wysocka J. (2001)
  319. Anticoagulant and antiprotease profiles of a novel na tural heparinomimetic mannopentaose phosphate sulfate (PI-88). (PubMed id 11292191)9 Demir M....Fareed J. (2001)
  320. Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication. (PubMed id 11782701)9 Diamantopoulos E.J....Raptis S.A. (2001)
  321. Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation. (PubMed id 11374774)9 King B.O....Chen J.C. (2001)
  322. The mechanism of action of thrombin inhibitors. (PubMed id 11156731)9 Bates S.M. and Weitz J.I. (2000)
  323. Human LTC-IC can be maintained for at least 5 weeks in vitro when interleukin-3 and a single chemokine are combined with O-sulfated heparan sulfates: requirement for optimal binding interactions of heparan sulfate with early-acting cytokines and matrix proteins. (PubMed id 10607697)9 Gupta P....Verfaillie C.M. (2000)
  324. Suppressive effect of saprogrelate hydrochloride on Raynaud's phenomenon and respiratory failure in patients with systemic sclerosis. (PubMed id 10728728)9 Kato S....Kumamoto H. (2000)
  325. Reduction of heparin dose is not beneficial to platelet function. (PubMed id 10921706)9 Nakajima T....Nitatori T. (2000)
  326. Platelet activation and its role in thrombin generation in platelet-induced thrombin generation time. (PubMed id 11150585)9 Radziwon P....Breddin H.K. (2000)
  327. Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation. (PubMed id 11077138)9 Mondillo S....Nami R. (2000)
  328. Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. (PubMed id 10688805)9 Arepally G.M....Poncz M. (2000)
  329. Affinity purification of heparin-dependent antibodies to platelet factor 4 developed in heparin-induced thrombocytopenia: biological characteristics and effects on platelet activation. (PubMed id 10848821)9 Amiral J....Gruel Y. (2000)
  330. Cytokines in WBC-reduced apheresis PCs during storage: a comparison of two WBC-reduction methods. (PubMed id 10988316)9 Wadhwa M....Thorpe R. (2000)
  331. Investigation of a platelet factor 4 polymorphism on the immune response in patients with heparin-induced thrombocytopenia. (PubMed id 10938877)9 Horsewood P. and Kelton J.G. (2000)
  332. Platelet factor 4-induced neutrophil-endothelial cell interaction: involvement of mechanisms and functional consequences different from those elicited by interleukin-8. (PubMed id 10590045)9 Petersen F....Brandt E. (1999)
  333. [The role of nitric oxide and blood platelets in pathogenesis of preeclampsia] (PubMed id 10390913)9 Bielecki M....Bielecki D.A. (1999)
  334. Drug-induced immune thrombocytopenia: an overview of pathogenesis. (PubMed id 9930556)9 Aster R.H. (1999)
  335. Comparative study of antiplatelet drugs in vitro: distinct effects of cAMP-elevating drugs and GPIIb/IIIa antagonists on thrombin-induced platelet responses. (PubMed id 10403683)9 Matsumoto Y....Kimura Y. (1999)
  336. PDGF-AB release during and after haemodialysis procedure. (PubMed id 10528666)9 Cianciolo G....La Hanna G. (1999)
  337. Chemokine production by human megakaryocytes derived from CD34-positive cord blood cells. (PubMed id 10346982)9 Takeuchi K....Koike K. (1999)
  338. A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation. (PubMed id 9780212)9 Petersen F....Brandt E. (1998)
  339. Protamine reversal of heparin affects platelet aggreg ation and activated clotting time after cardiopulmonary bypass. (PubMed id 9768770)9 Mochizuki T....Levy J.H. (1998)
  340. Platelet count, anti-heparin/platelet factor 4 antibo dies and tissue factor pathway inhibitor plasma antigen level in chronic dialys is. (PubMed id 9622039)9 Luzzatto G....Girolami A. (1998)
  341. In vitro efficacy of platelet glycoprotein IIb/IIIa antagonist in blocking platelet function in plasma of patients with heparin-induced thrombocytopenia. (PubMed id 9869172)9 Mak K.H....Topol E.J. (1998)
  342. [Selected parameters of blood platelet function in patients with myeloproliferative syndrome] (PubMed id 9857536)9 Zuk E. (1998)
  343. beta-Thromboglobulin and 11-dehydrothromboxane B in tension-type headache. (PubMed id 15613179)9 Oishi M. and Mochizuki Y. (1998)
  344. Prethrombotic state due to hypercoagulability in patients with permanent transvenous pacemakers. (PubMed id 9342969)9 Ito T....Kamada T. (1997)
  345. Elevated platelet factor 4 and beta-thromboglobulin plasma levels in depressed patients with ischemic heart disease. (PubMed id 9270907)9 Laghrissi-Thode F....Finkel M.S. (1997)
  346. Characterization of the humoral immune response in heparin-induced thrombocytopenia. (PubMed id 9067497)9 Suh J.S....Visentin G.P. (1997)
  347. Heparin inhibits the binding of basic fibroblast growth factor to cultured human aortic smooth-muscle cells. (PubMed id 9307014)9 Bono F....Herbert J.M. (1997)
  348. Fibronectin, platelet factor 4 and beta-thromboglobulin in endemic hepatosplenic schistosomiasis: relation to acute hematemesis. (PubMed id 9097085)9 el-Bassiouni N.E....el-Khayat H.R. (1997)
  349. Impact of buffy coat storage on the generation of inflammatory cytokines and platelet activation. (PubMed id 9111272)9 KlA1ter H....Kirchner H. (1997)
  350. Atrial fibrillation activates platelets and coagulation in a time-dependent manner: a study in patients with paroxysmal atrial fibrillation. (PubMed id 8996302)9 Sohara H....Miyahara K. (1997)
  351. Increased activation of the coagulation and fibrinolytic systems leads to hemorrhagic complications during left ventricular assist implantation. (PubMed id 8901751)9 Livingston E.R....Jeevanandam V. (1996)
  352. Chemokines in stored platelet concentrates. (PubMed id 8693510)9 Bubel S....KlA1ter H. (1996)
  353. Randomized trial of recombinant platelet factor 4 ver sus protamine for the reversal of heparin anticoagulation in humans. (PubMed id 8901773)9 Dehmer G.J....Bonnem E.M. (1996)
  354. Platelet and blood clotting activation in patients with mitral valve prolapse. (PubMed id 8870174)9 Martini F....Gensini G. (1996)
  355. Inhibitory effects of Acanthopanax gracilistylus saponins on human platelet aggregation and platelet factor 4 liberation in vitro. (PubMed id 9863147)9 Chen X.C....Huang G. (1996)
  356. Hypercoagulable state in patients with Takayasu's arteritis. (PubMed id 8725710)9 Akazawa H....Shimada K. (1996)
  357. [Changes of the plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in cerebral infarction induced by the venous occlusion] (PubMed id 8531402)9 Wakamatsu S....Oguri T. (1995)
  358. Flow cytometric evaluation of platelet activation by ionic or nonionic contrast media and modulation by heparin and recombinant hirudin. (PubMed id 7782193)9 Koza M.J....Pifarre R. (1995)
  359. Platelet activation is not involved in acceleration of the coagulation system in acute cardioembolic stroke with nonvalvular atrial fibrillation. (PubMed id 7631338)9 Nagao T....Terashi A. (1995)
  360. Inhibition of development of murine melanoma lung metastases by systemic administration of recombinant platelet factor 4. (PubMed id 7707422)9 Kolber D.L....Maione T.E. (1995)
  361. Three-dimensional structures of alpha and beta chemokines. (PubMed id 7821760)9 Clore G.M. and Gronenborn A.M. (1995)
  362. Usefulness of coagulation markers in staging of gastric cancer. (PubMed id 7553675)9 Abbasciano V....Liboni A. (1995)
  363. Coagulation activity is increased in the left atrium of patients with mitral stenosis. (PubMed id 7646626)9 Yamamoto K....Shimada K. (1995)
  364. Protective effect of basic fibroblast growth factor-heparin and neurotoxic effect of platelet factor 4 on ischemic neuronal loss and learning disability in gerbils. (PubMed id 7777164)9 Wen T.C....Sakanaka M. (1995)
  365. The coagulation system is activated in idiopathic cardiomyopathy. (PubMed id 7539015)9 Yamamoto K....Shimada K. (1995)
  366. [Antiplatelet therapy in patients with cerebral thrombosis at the chronic phase--assessment of its effect on coagulation and fibrinolytic parameters] (PubMed id 7994982)9 Kohriyama T....Nakamura S. (1994)
  367. Structural requirements of platelet chemokines for neutrophil activation. (PubMed id 7919350)9 Yan Z....Poncz M. (1994)
  368. Influence of Pall Pl-50 platelet filters on lactate d ehydrogenase, platelet factor 4, and complement factor 3 in stored platelet con centrates. (PubMed id 7950293)9 JAoremo P. (1994)
  369. [Change of platelet function after the beginning of repeated hemodialysis treatment in patients with uremia] (PubMed id 7716051)9 Krawczyk W....RA^zyc P. (1994)
  370. Platelet release reaction during EDTA-induced platelet agglutinations and inhibition of EDTA-induced platelet agglutination by anti-glycoprotein II b/III a complex monoclonal antibody. (PubMed id 8042193)9 Ryo R....Yamaguchi N. (1994)
  371. Maturation of human megakaryocytic cell line (CMK-7) on the human umbilical vein endothelial cell (EC) monolayer. (PubMed id 8011988)9 Hoshi M....Mitsui Y. (1994)
  372. Platelets deficient in glycoprotein IIIb aggregate normally to collagens type I and III but not to collagen type V. (PubMed id 7694682)9 Kehrel B....Clemetson K.J. (1993)
  373. A low volume specimen container suitable for monitori ng the aPTT of heparinized patients. (PubMed id 8292732)9 Ray M.J....Hawson G.A. (1993)
  374. Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg. (PubMed id 8475106)9 Clark-Lewis I....Baggiolini M. (1993)
  375. Expression of mRNA for serglycin core protein and other platelet alpha granule proteins is increased in human erythroleukemia cells by phorbol myristate acetate. (PubMed id 7504770)9 Schick B.P. and Thornton R.D. (1993)
  376. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression. (PubMed id 7682242)9 Broxmeyer H.E....Ralph P. (1993)
  377. Activation of human basophils through the IL-8 receptor. (PubMed id 1383321)9 Krieger M....Dahinden C.A. (1992)
  378. Blood platelets stimulate the expression of chondroit in sulfate proteoglycan in human monocytes. (PubMed id 1498323)9 Uhlin-Hansen L....Kolset S.O. (1992)
  379. Modulation of protein C inhibitor activity by histidine-rich glycoprotein and platelet factor 4: role of zinc and calcium ions in the heparin-neutralizing ability of histidine-rich glycoprotein. (PubMed id 1319617)9 Kazama Y. and Koide T. (1992)
  380. Platelet factor 4 gene expression in a human megakaryocytic leukemia cell line (CMK) and its differentiated subclone (CMK11-5). (PubMed id 1893970)9 Adachi M....Yamaguchi N. (1991)
  381. Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity. (PubMed id 1706960)9 Maione T.E....Sharpe R.J. (1991)
  382. Thromboembolic risk in children with nephrotic syndrome. (PubMed id 1806458)9 De Mattia D....Schettini F. (1991)
  383. Low molecular weight heparin-catalyzed inactivation of factor Xa and thrombin by antithrombin III--effect of platelet factor 4. (PubMed id 1665594)9 Schoen P....Hemker H.C. (1991)
  384. [The changes in plasma beta-thromboglobulin (beta-TG), platelet factor 4 (PF4) and thromboxane B2 (TXB2) after a bronchial provocation test (BPT) with house dust (HD) allergen] (PubMed id 1831967)9 Mizuno M....Takahashi T. (1991)
  385. Abnormal levels of platelet-specific proteins and mitogenic activity in myeloproliferative disease. (PubMed id 1826402)9 Rueda F....Pujol-Moix N. (1991)
  386. Induction of local inflammation by recombinant human platelet factor 4 in the mouse. (PubMed id 1884399)9 Sharpe R.J....Maione T.E. (1991)
  387. [Platelets and migraine. Correlation between biochemical markers of platelet aggregation and serotonin] (PubMed id 1830748)9 Leira R....Noya M. (1991)
  388. Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine. (PubMed id 2118520)9 Vanguri P. and Farber J.M. (1990)
  389. High heparin released platelet factor 4 in uncomplica ted type 1 diabetes mellitus. (PubMed id 2143603)9 Cortellaro M....Polli E.E. (1990)
  390. The effect of different agitation modes on platelet metabolism, thromboxane formation, and alpha-granular release during platelet storage. (PubMed id 2119532)9 Wallvik J....Akerblom O. (1990)
  391. Growth inhibition of murine melanoma and human colon carcinoma by recombinant human platelet factor 4. (PubMed id 1692094)9 Sharpe R.J....Maione T.E. (1990)
  392. [Biological manifestations of a prethrombotic state in developmental Crohn's disease] (PubMed id 2188861)9 Chamouard P....Cazenave J.P. (1990)
  393. [Erythrocytes infected by Plasmodium falciparum activate human platelets] (PubMed id 2142012)9 Polack B....Ambroise-Thomas P. (1990)
  394. Effect of cellulose acetate 0.2 micron filter on platelet specific proteins plasma levels. (PubMed id 1703106)9 Stevanato F....Cella G. (1990)
  395. Evaluation of platelet activation, coagulation, and f ibrinolytic activation in patients with symptomatic lacunar stroke. (PubMed id 20445428)9 Ilhan D....GA1lbaAss Z. (2010)
  396. Changes in platelets and anticoagulant protein activi ty during adenosine-exercise single-photon emission computed tomography stress test. (PubMed id 20229679)9 ObradoviA8 S....GligiA8 B. (2010)
  397. Heparin-induced thrombocytopenia. (PubMed id 20059332)9 Arepally G.M. and Ortel T.L. (2010)
  398. Role of the platelet chemokine platelet factor 4 (PF4 ) in hemostasis and thrombosis. (PubMed id 20004006)9 Kowalska M.A....Poncz M. (2010)
  399. Studies of the anti-platelet factor 4/heparin immune response: adapting the enzyme-linked immunosorbent spot assay for detection of memory B cells against complex antigens. (PubMed id 19709391)9 Selleng K....Greinacher A. (2010)
  400. CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages. (PubMed id 20335529)9 Gleissner C.A....Ley K. (2010)
  401. Serum protein signature may improve detection of duct al carcinoma in situ of the breast. (PubMed id 19855429)9 Solassol J....MangAc A. (2010)
  402. Immune mechanisms in heparin-induced thrombocytopenia : no evidence for immunoglobulin M anti-idiotype antibodies. (PubMed id 19497062)9 Selleng K....Greinacher A. (2009)
  403. Apolipoprotein A-I and platelet factor 4 are biomarke rs for infliximab response in rheumatoid arthritis. (PubMed id 18664547)9 TrocmAc C....Gaudin P. (2009)
  404. [Heparin-induced thrombocytopenia occurring after sur gical treatment of atrial myxoma--a case report] (PubMed id 19950764)9 DjuniA8 I....ElezoviA8 I. (2009)
  405. The role of the extracorporeal circuit in the trappin g and degranulation of platelets. (PubMed id 19684392)9 Gritters-van den Oever M....NubAc M.J. (2009)
  406. Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering. (PubMed id 19360286)9 Chattopadhyay I....Saxena S. (2009)
  407. A surface plasmon resonance-based solution affinity a ssay for heparan sulfate-binding proteins. (PubMed id 19034645)9 Cochran S....Ferro V. (2009)
  408. Intermittent pneumatic compression in stable claudica nts: effect on hemostasis and endothelial function. (PubMed id 19935591)9 Sutkowska E....Wysokinski W.E. (2009)
  409. Heparin induced thrombocytopenia and thrombosis in a tertiary care hospital. (PubMed id 19195684)9 Ban-Hoefen M. and Francis C. (2009)
  410. Post-dilution haemodiafiltration and low-flux haemodi alysis have dissimilar effects on platelets: a side study of CONTRAST. (PubMed id 19561150)9 Gritters-van den Oever M....NubAc M.J. (2009)
  411. Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis. (PubMed id 19208360)9 Dominguez M....Bataller R. (2009)
  412. Chemokine degradation by the Group A streptococcal se rine proteinase ScpC can be reconstituted in vitro and requires two separate do mains. (PubMed id 19552626)9 Fritzer A....Meinke A.L. (2009)
  413. Intradialytic and postdialytic platelet activation, i ncreased platelet phosphatidylserine exposure and ultrastructural changes in pl atelets in children with chronic uremia. (PubMed id 19521197)9 Elshamaa M.F....Helmy A. (2009)
  414. Coagulation activity is increased in the left atria o f patients with paroxysmal atrial fibrillation during the non-paroxysmal period . Comparison with chronic atrial fibrillation. (PubMed id 19521017)9 Motoki H....Ikeda U. (2009)
  415. Identification of heparin-binding sites in proteins b y selective labeling. (PubMed id 19567366)9 Ori A....Fernig D.G. (2009)
  416. Platelet factor 4/CXCL4-stimulated human monocytes induce apoptosis in endothelial cells by the release of oxygen radicals. (PubMed id 18203873)9 Woller G....Petersen F. (2008)
  417. Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation. (PubMed id 18333911)9 Kim Y.T....Kang H.J. (2008)
  418. Platelet function in cutaneous diseases. (PubMed id 18791936)9 Kasperska-Zajac A....Rogala B. (2008)
  419. [Establishment of sprouting embryoid body model mimicking early embryonic vasculogenesis in human embryo] (PubMed id 19080715)9 Jiang H....Chen T. (2008)
  420. Altered gene expression patterns in dendritic cells after severe trauma: implications for systemic inflammation and organ injury. (PubMed id 18323745)9 Maier M....Marzi I. (2008)
  421. Heparin-induced thrombocytopenia--therapeutic concent rations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhi bit formation of platelet factor 4-heparin complexes. (PubMed id 18983520)9 Krauel K....Greinacher A. (2008)
  422. Thrombocytopenia after total knee arthroplasty. (PubMed id 19226055)9 Pesce V....Spinarelli A. (2008)
  423. Emerging treatments for thrombocytopenia: increasing platelet production. (PubMed id 18602017)9 Peeters K....Freson K. (2008)
  424. Platelet factor 4 mediates inflammation in experimental cerebral malaria. (PubMed id 18692777)9 Srivastava K....Morrell C.N. (2008)
  425. Heparin-induced thrombocytopenia complicated by warfa rin-induced skin necrosis. (PubMed id 18541684)9 Howard-Thompson A....Finch C.K. (2008)
  426. The approach to heparin-induced thrombocytopenia. (PubMed id 18302088)9 Linkins L.A. and Warkentin T.E. (2008)
  427. TGF-beta signalling-related markers in cancer patients with bone metastasis. (PubMed id 18270872)9 Baselga J....Carducci M. (2008)
  428. Thrombopoietin following transfusion of platelets in preterm neonates. (PubMed id 18925510)9 Kline A....Paul D.A. (2008)
  429. Delayed-onset HIT caused by low-molecular-weight heparin manifesting during fondaparinux prophylaxis. (PubMed id 18803278)9 Alsaleh K.A....Arnold D.M. (2008)
  430. Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (PubMed id 17895512)9 Shelat S.G....Pollak E.S. (2008)
  431. The immediate effect of aerobic exercise on haemostatic parameters in patients with recently diagnosed mild to moderate essential hypertension. (PubMed id 17551668)9 Lekakis J....Kremastinos D.T. (2008)
  432. Impact of the therapy by renin-angiotensin system targeting antihypertensive agents perindopril versus telmisartan on prothrombotic state in essential hypertension. (PubMed id 18305548)9 Remkova A....Durina J. (2008)
  433. Structure of mouse IP-10, a chemokine. (PubMed id 18560148)9 Jabeen T....Acharya K.R. (2008)
  434. Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism. (PubMed id 18983505)9 Abdelmalik N....Kamphuisen P.W. (2008)
  435. Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. (PubMed id 18291705)9 Petrai I....Marra F. (2008)
  436. Phase I study of eptifibatide in patients with sickle cell anaemia. (PubMed id 17916103)9 Lee S.P....Parise L.V. (2007)
  437. [Two surgical case reports showing atypical heparin-induced thrombocytopenia] (PubMed id 17252251)9 HAPhnke C. and Haas S. (2007)
  438. CXC chemokines located in the 4q21 region are up-regulated in breast cancer. (PubMed id 18045955)9 Bieche I....Lazennec G. (2007)
  439. Plasminogen activation by fibroblasts from periodontal ligament and gingiva is not directly affected by chemokines in vitro. (PubMed id 17296163)9 Sarajlic J....Gruber R. (2007)
  440. Heparin-induced thrombocytopenia in left ventricular assist device bridge-to-transplant patients. (PubMed id 17720387)9 Schroder J.N....Milano C.A. (2007)
  441. Heparin-induced thrombocytopenia: a frequent complica tion after cardiac surgery. (PubMed id 17893639)9 Pouplard C....Gruel Y. (2007)
  442. Anti-heparin/PF4 complexes by ELISA in patients with disseminated intravascular coagulation. (PubMed id 20224256)9 Matsuo T....Wanaka K. (2007)
  443. [Skin and mucosal ulcerations in heparin-induced thrombocytopenia (HIT) II] (PubMed id 17429586)9 Helbig D....Dissemond J. (2007)
  444. Heparin-induced thrombocytopenia: impact of bovine versus porcine heparin in HIT pathogenesis. (PubMed id 17485301)9 Ahmad S. (2007)
  445. Heparin-platelet factor 4 antibodies in patients presenting to the ED with thrombosis. (PubMed id 17349901)9 Francis J.L....Levine R.L. (2007)
  446. Bivalirudin: a new promising direct antithrombin. (PubMed id 19124943)9 Bhambhani A. and Meier B. (2007)
  447. Beta-thromboglobulin and platelet factor 4 in juvenile myocardial infarction. (PubMed id 17164501)9 Caimi G....Lo Presti R. (2007)
  448. Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects. (PubMed id 17896955)9 Castelli R....Fabris F. (2007)
  449. Influence of sample collection and storage on the detection of platelet factor 4-heparin antibodies. (PubMed id 17580283)9 Krakow E.F....Arepally G.M. (2007)
  450. Platelet-derived chemokines in vascular biology. (PubMed id 17479180)9 von Hundelshausen P....Brandt E. (2007)
  451. Heparin-induced skin necrosis associated with thrombocytopenia and acquired protein C and protein S deficiency. (PubMed id 17722075)9 Prasad H.K. and Govindarajan R. (2007)
  452. Prospective evaluation of the '4Ts' score and particle gel immunoassay specific to heparin/PF4 for the diagnosis of heparin-induced thrombocytopenia. (PubMed id 17362241)9 Pouplard C....Gruel Y. (2007)
  453. Sulodexide for hemodialysis anticoagulation in heparin-induced thrombocytopenia type II. (PubMed id 17557272)9 Borawski J....Mysliwiec M. (2007)
  454. Anticoagulants and their reversal. (PubMed id 17174219)9 Schulman S. and Bijsterveld N.R. (2007)
  455. [Heparin-induced thrombocytopenia] (PubMed id 16739902)9 Gruel Y....Pouplard C. (2006)
  456. Heparin-induced thrombocytopenia type II: a rare but significant complication of plasma exchange. (PubMed id 16342191)9 H Laird J....Green R. (2006)
  457. The role of endothelin-1 and selected cytokines in the pathogenesis of Raynaud's phenomenon associated with systemic connective tissue diseases. (PubMed id 16763543)9 Rychlik-Golema W....Adamiec R. (2006)
  458. Manipulation of hydrogel assembly and growth factor d elivery via the use of peptide-polysaccharide interactions. (PubMed id 16890321)9 Zhang L....Kiick K.L. (2006)
  459. Chemokine expression in human erythroid leukemia cell line AS-E2: macrophage inflammatory protein-3alpha/CCL20 is induced by inflammatory cytokines. (PubMed id 16413387)9 Inoue Y....Tomonaga M. (2006)
  460. The role of surface PF4: glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT). (PubMed id 16855346)9 Poncz M....Cines D.B. (2006)
  461. [Thrombocytosis: adverse effect of heparin treatment] (PubMed id 16462666)9 Camou F....Pellegrin J.L. (2006)
  462. Clinical and laboratory features, pathobiology of platelet-mediated thrombosis and bleeding complications, and the molecular etiology of essential thrombocythemia and polycythemia vera: therapeutic implications. (PubMed id 16673274)9 Michiels J.J....Schroyens W. (2006)
  463. Serum adenosine deaminase enzyme and plasma platelet factor 4 activities in active pulmonary tuberculosis, HIV-seropositive subjects and cancer patients. (PubMed id 16102836)9 Tarhan G....Cesur S. (2006)
  464. Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (PubMed id 16466367)9 Juhl D....Greinacher A. (2006)
  465. Mast cells in neoangiogenesis. (PubMed id 16501434)9 Nienartowicz A....Lemancewicz D. (2006)
  466. Disseminated intravascular clotting associated with F c-receptor IIa-mediated platelet activation in a patient with endocarditis afte r aortic valve replacement. (PubMed id 16914467)9 Kottenberg-Assenmacher E....Peters J. (2006)
  467. Elevation in plasma Abeta42 in geriatric depression: a pilot study. (PubMed id 16583267)9 Pomara N....Pollock B.G. (2006)
  468. Angiogenesis--a new target for future therapy. (PubMed id 16545987)9 Pandya N.M....Santani D.D. (2006)
  469. In vitro evaluation of Haemonetics MCS+ apheresis platelet concentrates treated with photochemical pathogen inactivation following plasma volume reduction using the INTERCEPT Preparation Set. (PubMed id 16430671)9 Isola H....Cazenave J.P. (2006)
  470. Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization. (PubMed id 16875910)9 Foo S.Y....Jang I.K. (2006)
  471. The paradox of platelet activation and impaired function: platelet-von Willebrand factor interactions, and the etiology of thrombotic and hemorrhagic manifestations in essential thrombocythemia and polycythemia vera. (PubMed id 16977569)9 Michiels J.J....van Vliet H.H. (2006)
  472. Heparin- induced thrombocytopenia occurring in the fi rst trimester of pregnancy: successful treatment with lepirudin. A case report. (PubMed id 16923524)9 Furlan A....Prandoni P. (2006)
  473. Influence of angiogenesis inhibitors on endothelial c ell morphology in vitro. (PubMed id 16643188)9 Friis T....Engel A.M. (2006)
  474. [Heparin-induced thrombocytopenia: report of four cases in severely burned patients] (PubMed id 17034986)9 Bargues L....Carsin H. (2006)
  475. Pseudo-pulmonary embolism as a sign of acute heparin-induced thrombocytopenia in hemodialysis patients: safety of resuming heparin after disappearance of HIT antibodies. (PubMed id 16902310)9 Hartman V....ZachAce P. (2006)
  476. [Advancement of platelet activation measurement: focusing on platelet-derived microparticle measurement] (PubMed id 16637573)9 Hayasaka K....Matsuno K. (2006)
  477. Citrate anticoagulation abolishes degranulation of polymorphonuclear cells and platelets and reduces oxidative stress during haemodialysis. (PubMed id 16144857)9 Gritters M....NubAc M.J. (2006)
  478. Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases. (PubMed id 16263791)9 Kasper B....Petersen F. (2006)
  479. Cytokine release of mononuclear leukocytes (PBMC) after contact to a carbonated calcium phosphate bone cement. (PubMed id 16602090)9 Schildhauer T.A....KAPller M. (2006)
  480. Cytokine accumulation in photochemically treated and gamma-irradiated platelet concentrates during storage. (PubMed id 16686848)9 Apelseth T.O....Bruserud O. (2006)
  481. Diagnosis and management of heparin-induced thrombocytopenia. (PubMed id 16766786)9 de Maistre E....Lasne D. (2006)
  482. HIT: lessons learned. (PubMed id 16855347)9 Warkentin T.E. (2006)
  483. Progress of epidemiological and molecular epidemiological studies on benzene in China. (PubMed id 17119257)9 Li G. and Yin S. (2006)
  484. JAS-R, a new megakaryo-erythroid leukemic cell line that secretes erythropoietin. (PubMed id 16619478)9 Sekikawa T....Yamada H. (2006)
  485. Coagulation activation and expression of CD40 ligand on platelets upon in vitro lipopolysaccharide-challenge in patients with unstable angina. (PubMed id 16182391)9 Kalsch T....Dempfle C.E. (2006)
  486. Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. (PubMed id 15925775)9 Tombul T....Anlar O. (2005)
  487. TEL/ETV6 accelerates erythroid differentiation and inhibits megakaryocytic maturation in a human leukemia cell line UT-7/GM. (PubMed id 15958056)9 Takahashi W....Mitani K. (2005)
  488. Changes in platelet count after cardiac surgery can effectively predict the development of pathogenic heparin-dependent antibodies. (PubMed id 15755289)9 Pouplard C....Gruel Y. (2005)
  489. Blood-based biomarkers for detecting mild osteoarthritis in the human knee. (PubMed id 16139532)9 Marshall K.W....Liew C.C. (2005)
  490. Development of antibodies specific to polyanion-modif ied platelet factor 4 during treatment with fondaparinux. (PubMed id 16359523)9 Pouplard C....Gruel Y. (2005)
  491. [Clinical classification for lacunar infarct. An investigation of 130 consecutive cases of lacunar infarctions] (PubMed id 15714993)9 Ohara T....Nakagawa M. (2005)
  492. Treatment of symptomatic patients with essential thrombocythemia: effectiveness of anagrelide. (PubMed id 16138352)9 Cacciola R.R....Cacciola E. (2005)
  493. [The secretory activity of blood platelets--beta-thro mboglobulin and platelet factor 4 in echinococcosis] (PubMed id 16245426)9 Matowicka-Karna J....Butkiewicz A. (2005)
  494. Platelet factor 4 gene transfection into tumor cells inhibits angiogenesis, tumor growth and metastasis. (PubMed id 15868918)9 Yamaguchi K....Hirose K. (2005)
  495. Effect of fondaparinux on platelet activation in the presence of heparin-dependent antibodies: a blinded comparative multicenter study with unfractionated heparin. (PubMed id 15388575)9 Savi P....Herbert J.M. (2005)
  496. [Primary exploration on immune associated genome of p atients with Pi-Qi deficiency syndrome] (PubMed id 15892273)9 Luo Y.J....Huang S.P. (2005)
  497. Effect of hirudin versus heparin on hemocompatibility of blood contacting biomaterials: an in vitro study. (PubMed id 16404704)9 Kopp R....Kuhlen R. (2005)
  498. Synthetic heparin derivatives as new anticoagulant drugs. (PubMed id 15922935)9 de Kort M....van Boeckel C.A. (2005)
  499. Safety of recombinant human factor XIII in a cynomolgus monkey model of extracorporeal blood circulation. (PubMed id 16243775)9 Ponce R....Rogge M. (2005)
  500. Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. (PubMed id 15932816)9 Serebruany V.L....Glassman A.H. (2005)
  501. Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin. (PubMed id 16109780)9 Warkentin T.E....Kelton J.G. (2005)
  502. Laboratory testing for the antibodies that cause heparin-induced thrombocytopenia: how much class do we need? (PubMed id 16310517)9 Warkentin T.E....Kelton J.G. (2005)
  503. Incidence of heparin-induced thrombocytopenia and therapeutic strategies in pediatric cardiac surgery. (PubMed id 15620916)9 BAPning A....Cremer J.T. (2005)
  504. Heparin-induced thrombocytopenia complicated with mas sive thrombosis of the inferior vena cava after filter placement. (PubMed id 16355099)9 Ishibashi H....Ishiguchi T. (2005)
  505. Autologous platelets as a source of proteins for heal ing and tissue regeneration. (PubMed id 14691563)9 Anitua E....Nurden A.T. (2004)
  506. New anticoagulants for treatment of venous thromboembolism. (PubMed id 15339877)9 Weitz J.I. (2004)
  507. [The effects of culture supernatant of human GRC-1 ce lls transfected with PF4 cDNA on the VEGF expression and the growth of ECV304 c ells] (PubMed id 15193222)9 Chang Z....Sun Q. (2004)
  508. Release of endothelium-associated proteins into blood by injection of heparin in normal subjects and in patients with Type 1 diabetes. (PubMed id 15384962)9 Myrup B....Olivecrona T. (2004)
  509. Titre of anti-heparin/PF4-antibodies and extent of in vivo activation of the coagulation and fibrinolytic systems. (PubMed id 14961154)9 Chilver-Stainer L....Alberio L. (2004)
  510. Generation of functional culture-derived platelets fr om CD34+ progenitor cells to study transgenes in the platelet environment. (PubMed id 15297382)9 Ungerer M....Gawaz M. (2004)
  511. A critical evaluation of assays for detecting antibodies to the heparin-PF4 complex. (PubMed id 15282659)9 Francis J.L. (2004)
  512. Regional left atrial coagulation and fibrinolytic activities in patients with mitral stenosis. (PubMed id 15557719)9 Boyaci A....Korkmaz S. (2004)
  513. Prevalance of heparin-dependent platelet-activating antibodies in preterm newborns after exposure to unfractionated heparin. (PubMed id 15497019)9 Kumar P....Walenga J.M. (2004)
  514. Effect of modified ultrafiltration on inflammatory mediators, coagulation factors, and other proteins in blood after an extracorporeal circuit. (PubMed id 15046631)9 Fujita M....Maehara T. (2004)
  515. Shift in the balance between circulating thrombospondin-1 and vascular endothelial growth factor in cancer patients: relationship to platelet alpha-granule content and primary activation. (PubMed id 15503824)9 Gonzalez F.J....Alba E. (2004)
  516. [Heparin-induced thrombocytopenia. Pathogenesis, diagnosis and treatment] (PubMed id 14736559)9 Gruel Y. (2004)
  517. Heparin-induced thrombocytopenia and thrombosis in a patient with polycythemia vera. (PubMed id 15335186)9 Hayashi T....Nomura T. (2004)
  518. Heparin-induced thrombocytopenia during renal replacement therapy. (PubMed id 19379430)9 Davenport A. (2004)
  519. Special considerations with fondaparinux therapy: heparin-induced thrombocytopenia and wound healing. (PubMed id 15317404)9 Dager W.E....Nutescu E. (2004)
  520. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. (PubMed id 15459074)9 Struyf S.... Strieter R.M. (2004)
  521. Thrombopoietin-induced Dami cells as a model for alpha-granule biogenesis. (PubMed id 15370095)9 Briquet-Laugier V....Rosa J.P. (2004)
  522. Effect of physical exercise on platelet activity and the von-Willebrand-factor in patients with persistent lone atrial fibrillation. (PubMed id 15014214)9 Goette A....Klein H.U. (2004)
  523. Blood coagulation kinetics: high throughput method for real-time reaction monitoring. (PubMed id 15467920)9 Lo K. and Diamond S.L. (2004)
  524. Effects of anagrelide on platelet factor 4 and vascular endothelial growth factor levels in patients with essential thrombocythemia. (PubMed id 15352995)9 Cacciola R.R....Cacciola E. (2004)
  525. Blood damage related to cardiopulmonary bypass: in vivo and in vitro comparison of two different centrifugal pumps. (PubMed id 15497388)9 Paparella D....De Luca Tupputi Schinosa L. (2004)
  526. Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-mediated platelet activation in humans. (PubMed id 15654516)9 Hua J....Nagaoka I. (2004)
  527. Effects of anticoagulation intensity on hemostatic ma rkers in patients with non-valvular atrial fibrillation. (PubMed id 14695462)9 Nozawa T....Yano K. (2004)
  528. Radiolabeled chemotactic cytokines: new agents for scintigraphic imaging of infection and inflammation. (PubMed id 14973417)9 van Eerd J.E....Oyen W.J. (2003)
  529. Studies of alpha-granule proteins in cultured human megakaryocytes. (PubMed id 14597980)9 Veljkovic D.K....Hayward C.P. (2003)
  530. A prospective, double-blind study on the efficacy of the bioline surface-heparinized extracorporeal perfusion circuit. (PubMed id 12842526)9 Palatianos G.M....Melissari E.N. (2003)
  531. Dextran sulfate included in factor Xa assay reagent o verestimates heparin activity in patients after heparin reversal by protamine. (PubMed id 14693175)9 Mouton C....Vergnes M.C. (2003)
  532. Platelet activation induced by human antibodies to interleukin-8. (PubMed id 12393592)9 Regnault V....Lecompte T. (2003)
  533. Daily prickly pear consumption improves platelet func tion. (PubMed id 12878452)9 Wolfram R....Sinzinger H. (2003)
  534. Suppression of tumor growth by viral vector-mediated gene transfer of N-terminal truncated platelet factor 4. (PubMed id 14629831)9 Li Y....Han Z.C. (2003)
  535. [From heparin to synthetic antithrombotic oligosaccharides] (PubMed id 14556453)9 Petitou M. (2003)
  536. Platelet activation, inflammatory mediators and hypercholesterolemia. (PubMed id 15320841)9 Ferroni P....Davi G. (2003)
  537. Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparan sulphate. (PubMed id 12672474)9 Chadderton N.S. and Stringer S.E. (2003)
  538. Comparison of the effects of cellulose triacetate and polysulfone membrane on GPIIb/IIIa and platelet activation. (PubMed id 12601261)9 Kuragano T....Kanmatsuse K. (2003)
  539. Enhanced platelet/endothelial activation in depressed patients with acute coronary syndromes: evidence from recent clinical trials. (PubMed id 12960610)9 Serebruany V.L....O'Connor C.M. (2003)
  540. Anti-thrombin action of low-dose acetylsalicylic acid. (PubMed id 12535860)9 Di Micco B....Ragone R. (2003)
  541. Left atrial platelet activity with rheumatic mitral stenosis: correlation study of severity and platelet P-selectin expression by flow cytometry. (PubMed id 14605032)9 Chen M.C....Fu M. (2003)
  542. Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy. (PubMed id 12912814)9 Serebruany V.L....O'Connor C.M. (2003)
  543. Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts. (PubMed id 12781799)9 Michiels J.J. (2003)
  544. Abciximab inhibits procoagulant activity but not the release reaction upon collagen- or clot-adherent platelets. (PubMed id 12871419)9 Ilveskero S. and Lassila R. (2003)
  545. Comparative effects of two synthetic oligosaccharides on platelet activation induced by plasma from HIT patients. (PubMed id 12941044)9 Savi P....Herbert J.M. (2003)
  546. Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy. (PubMed id 12679759)9 Serebruany V.L....Gurbel P.A. (2003)
  547. Aggressive antiplatelet therapy before coronary stent implantation in acute coronary syndrome with essential thrombocythemia--a case report. (PubMed id 12934770)9 Fujimura M....Matsumoto T. (2003)
  548. Platelet function assays. (PubMed id 12725958)9 Rand M.L....Packham M.A. (2003)
  549. Non-oncologic applications of radiolabeled peptides in nuclear medicine. (PubMed id 14973420)9 Knight L.C. (2003)
  550. Phosphorylcholine coating offers natural platelet preservation during cardiopulmonary bypass. (PubMed id 11817528)9 De S.F....Van N.G. (2002)
  551. Delayed-onset heparin-induced thrombocytopenia. (PubMed id 11827497)9 Rice L....Francis J.L. (2002)
  552. EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation. (PubMed id 11922610)9 Shimizu S....Morishita K. (2002)
  553. Platelet activation and PDGF-AB release during dialysis. (PubMed id 12518957)9 Donati G....Stefoni S. (2002)
  554. Antimicrobial peptides from human platelets. (PubMed id 12438321)9 Tang Y.Q....Selsted M.E. (2002)
  555. Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia. (PubMed id 12460234)9 Hayashi M....Inaba N. (2002)
  556. Heparin induces differentiation of CD1a+ dendritic cells from monocytes: phenotypic and functional characterization. (PubMed id 11801647)9 Xia C.Q. and Kao K.J. (2002)
  557. Frequency of anti-heparin-platelet factor 4 antibodies in hemodialysis patients and correlation with recurrent vascular access thrombosis. (PubMed id 11835336)9 O'Shea S.I....Ortel T.L. (2002)
  558. Fondaparinux sodium. (PubMed id 12532174)9 Reverter J.C. (2002)
  559. Comparative antithrombotic potencies of direct thrombin inhibitors and low-molecular-weight heparins in an ex vivo human experimental thrombosis model. (PubMed id 12244485)9 Harenberg J....JAPrg I. (2002)
  560. The levels of five markers of hemostasis and endothelial status at different stages of normotensive pregnancy. (PubMed id 11966476)9 Hayashi M....Ohkura T. (2002)
  561. [Transfer of cDNAs of platelet factor 4 and N-truncated peptide inhibits solid tumor growth in vivo] (PubMed id 11953124)9 Li Y....Han Z. (2002)
  562. [The CXC-chemokine platelet factor 4 (PF4) increases KG1a cells adherence and modulates actin polymerization of KG1a cells] (PubMed id 12905835)9 Lu S.H....Han Z.C. (2002)
  563. Heparin-induced thrombocytopenia-associated thrombosis in pediatric intensive care patients. (PubMed id 11773578)9 Schmugge M....Fischer J.E. (2002)
  564. Relationships between thrombohemorrhagic complications and platelet function in patients with essential thrombocythaemia. (PubMed id 11559934)9 Raszeja-Specht A....Szutowicz A. (2001)
  565. Genetic screening of candidate genes for a prothrombotic interaction with type I protein C deficiency in a large kindred. (PubMed id 11204593)9 Scott B.T....Long G.L. (2001)
  566. Gelatinase B functions as regulator and effector in leukocyte biology. (PubMed id 11404367)9 Opdenakker G....Van Damme J. (2001)
  567. Delayed-onset heparin-induced thrombocytopenia and thrombosis. (PubMed id 11578153)9 Warkentin T.E. and Kelton J.G. (2001)
  568. [Role of the hemostatic system in the progression of acute glomerulonephritis] (PubMed id 11521520)9 Movchan E.A....Chuprova A.V. (2001)
  569. Comparison between different laboratory tests for the detection and prevention of heparin-induced thrombocytopenia. (PubMed id 11746104)9 Vitale M....Conte R. (2001)
  570. Matrix metalloproteinase-2 in platelet adhesion to fibrinogen: interactions with nitric oxide. (PubMed id 11433190)9 Martinez A....Radomski M.W. (2001)
  571. Sneddon syndrome with multiple cerebral infarctions 12 years after the onset of livedo vasculitis: a possible involvement of platelet activation. (PubMed id 11603394)9 Matsumura Y....Miyachi Y. (2001)
  572. Intra- and post-dialytic platelet activation and PDGF-AB release: cellulose diacetate vs polysulfone membranes. (PubMed id 11390724)9 Cianciolo G....Stefoni V. (2001)
  573. SR123781A, a synthetic heparin mimetic. (PubMed id 11372679)9 Herbert J.M....Petitou M. (2001)
  574. Low dose systemic heparinization combined with heparin-coated extracorporeal circulation. Effects related to platelets. (PubMed id 11562580)9 Mirow N....KAPrfer R. (2001)
  575. Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent diabetic patients with diabetic nephropathy. (PubMed id 11569481)9 Myrup B....Jespersen J. (2001)
  576. Determination of heparin-platelet factor 4-IgG antibodies improves diagnosis of heparin-induced thrombocytopenia. (PubMed id 11442479)9 Lindhoff-Last E....Bauersachs R. (2001)
  577. Biological significance of chemokine receptor expression by normal human megakaryoblasts. (PubMed id 11534779)9 Majka M....Ratajczak M.Z. (2001)
  578. Does parasitic infection affect platelet factor 4 concentration? (PubMed id 11780555)9 Matowicka-Karna J. and Kemona H. (2001)
  579. Shear-induced platelet activation and adhesion on human pulmonary artery endothelial cells seeded onto hydrophilic polymers. (PubMed id 11523037)9 Sagnella S....Kottke-Marchant K. (2001)
  580. Von Willebrand factor, a key protein in the exposure of CD62P on platelets. (PubMed id 11511037)9 Broberg M. and Nygren H. (2001)
  581. Cardiovascular effects of carbon monoxide and cigaret te smoking. (PubMed id 11704374)9 Zevin S....Benowitz N.L. (2001)
  582. Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice? (PubMed id 11851938)9 Boehlen F. and Clemetson K.J. (2001)
  583. Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. (PubMed id 11588041)9 Reilly M.P....McKenzie S.E. (2001)
  584. Fundamental concepts in the pathobiology of heparin-induced thrombocytopenia. (PubMed id 11155189)9 Januzzi Jr JL . and Jang I.K. (2000)
  585. [Soluble P-selectin - a marker of platelet activation and vessel wall injury: increase of soluble P-selectin in plasma of patients with myocardial infarction, massive atherosclerosis and primary pulmonary hypertension] (PubMed id 10833791)9 Semenov A.V....Mazurov A.V. (2000)
  586. Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy. (PubMed id 10826517)9 Freyberger H....Derwahl M. (2000)
  587. Platelet activation in the gyro C1E3 centrifugal pump: comparison with the terumo capiox and the Nikkiso HPM-15. (PubMed id 11119077)9 Kawahito K....Ino T. (2000)
  588. Plasma adenosine levels increase in women with normal pregnancies. (PubMed id 10819858)9 Yoneyama Y....Araki T. (2000)
  589. Suppressive effects of TNF-alpha, TGF-beta1, and chemokines on megakaryocytic colony formation in CD34+ cells derived from umbilical cord blood compared with mobilized peripheral blood and bone marrow. (PubMed id 10813532)9 Lu L....Broxmeyer H.E. (2000)
  590. Effect of i.v. tenoxicam during caesarean delivery on platelet activity. (PubMed id 10786742)9 Elhakim M....Mekawy M. (2000)
  591. Alterations in coagulation after implantation of a pulsatile Novacor LVAD and the axial flow MicroMed DeBakey LVAD. (PubMed id 10969675)9 Koster A....Hetzer R. (2000)
  592. Jostra Rota Flow RF-30 pump system: a new centrifugal blood pump for cardiopulmonary bypass. (PubMed id 10886061)9 Orime Y....Suzuki M. (2000)
  593. Heparin-induced thrombocytopenia. (PubMed id 10629596)9 Fabris F....Girolami A. (2000)
  594. Modulatory roles of RANTES in IL-4 production by human blood CD4(+)T cells. (PubMed id 10975998)9 Saito S....Kawakami Y. (2000)
  595. Acute effects of nicotine infusion on platelets in nicotine users with normal and impaired renal function. (PubMed id 10698667)9 Whiss P.A....Larsson R. (2000)
  596. Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. (PubMed id 11110672)9 Clemetson K.J....Wells T.N. (2000)
  597. Changes of the hemostatic network in critically ill patients--is there a difference between sepsis, trauma, and neurosurgery patients? (PubMed id 10708181)9 Boldt J....Piper S. (2000)
  598. Suppressive effect of sarpogrelate hydrochloride on respiratory failure and right ventricular failure with pulmonary hypertension in patients with systemic sclerosis. (PubMed id 11191719)9 Kato S....Kaneko N. (2000)
  599. Platelet factor 4 as a marker of platelet activation in patients with acute myocardial infarction. (PubMed id 11712446)9 Dymicka-Piekarska V....Bychowski J. (2000)
  600. Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO- alpha and leaves RANTES and MCP-2 intact. (PubMed id 11023497)9 Van den Steen P.E.... Opdenakker G. (2000)
  601. Coagulation system and platelets are fully activated in uncomplicated sepsis. (PubMed id 10708182)9 Mavrommatis A.C....Zakynthinos S. (2000)
  602. The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. (PubMed id 10807774)9 Sungaran R....Chong B.H. (2000)
  603. Molecular mechanisms of platelet exocytosis: requirements for alpha-granule release. (PubMed id 10673384)9 Lemons P.P....Whiteheart S.W. (2000)
  604. Newer antithrombin agents in acute coronary syndromes. (PubMed id 10577463)9 Antman E.M. and Cohen M. (1999)
  605. Nitric oxide diffusion across membrane lungs protects platelets during simulated extracorporeal circulation. (PubMed id 10231347)9 Keh D....Gerlach H. (1999)
  606. Takayasu's arteritis associated with factor V Leiden. (PubMed id 10072118)9 Shin D.D. and Godwin J.E. (1999)
  607. Measurement of endogenous and exogenous alpha-granular platelet proteins in patients with immune and nonimmune thrombocytopenia. (PubMed id 10468871)9 Hughes M....Kelton J.G. (1999)
  608. Changes in platelet ATP secretion and aggregation during pregnancy and in preeclampsia. (PubMed id 10452571)9 Hayashi M....Mitsuya K. (1999)
  609. The rationale and future potential of angiogenesis inhibitors in neoplasia. (PubMed id 10439927)9 Gasparini G. (1999)
  610. Physical mapping of the CXC chemokine locus on human chromosome 4. (PubMed id 10343098)9 O'Donovan N....Morgan J.G. (1999)
  611. Functional heterogeneity of antiheparin-platelet factor 4 antibodies: implications in the pathogenesis of the HIT syndrome. (PubMed id 10726034)9 Ahmad S....Fareed J. (1999)
  612. Significantly elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic dermatitis. (PubMed id 10319581)9 Watanabe O....Nakamura Y. (1999)
  613. Selective activity of various antiviral compounds against HHV-7 infection. (PubMed id 10480261)9 Zhang Y....De Clercq E. (1999)
  614. [Decreased plasma soluble P-selectin level in coronary sinus after successful coronary angioplasty in patients with unstable angina] (PubMed id 10354952)9 Doi N....Dohi K. (1999)
  615. A prospective study of G-CSF effects on hemostasis in allogeneic blood stem cell donors. (PubMed id 10373063)9 LeBlanc R....Cantin G. (1999)
  616. Angiogenesis inhibitors overcome tumor induced endothelial cell anergy. (PubMed id 9935216)9 Griffioen A.W....Groenewegen G. (1999)
  617. [Preeclampsia not (yet) predictable from the blood platelet count] (PubMed id 10086090)9 Lazarov R....Boer K. (1999)
  618. Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. (PubMed id 10593869)9 Sakiyama S.E....Hubbell J.A. (1999)
  619. Role of a serine/threonine kinase, Mst1, in megakaryocyte differentiation. (PubMed id 10581000)9 Sun S. and Ravid K. (1999)
  620. Synthesis of thrombin-inhibiting heparin mimetics wit hout side effects. (PubMed id 10201371)9 Petitou M....Herbert J.M. (1999)
  621. Epinephrine promotes IL-8 production in human leukocytes via an effect on platelets. (PubMed id 10348705)9 Engstad C.S....Osterud B. (1999)
  622. Increased formation of thromboxane in vivo in humans with mastocytosis. (PubMed id 10417625)9 Morrow J.D....Guzzo C. (1999)
  623. Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: a key to study an angiogenic marker in vivo? (PubMed id 10509160)9 Wynendaele W....van Oosterom A.T. (1999)
  624. Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action. (PubMed id 10419890)9 Jouan V....Bikfalvi A. (1999)
  625. Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation. (PubMed id 9568742)9 BrAPijersAcn A....Hjemdahl P. (1998)
  626. Cardiology for the primary care provider: heparin-induced thrombocytopenia. (PubMed id 9496863)9 Benton R.E. and Gersh B.J. (1998)
  627. Fundamentals of coagulation and glycoprotein IIb/IIIa receptor inhibition. (PubMed id 9597517)9 Ferguson J.J....Wilson J.M. (1998)
  628. Heparin-induced thrombocytopenia: diagnostic tests and biological mechanisms. (PubMed id 10097819)9 Amiral J. and Meyer D. (1998)
  629. CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2. (PubMed id 9551928)9 Sanchez X....Navarro J. (1998)
  630. [The role of chemokines such as RANTES in allergic disease] (PubMed id 9760835)9 Chihara J. (1998)
  631. [Biological diagnosis and surveillance of heparin-induced thrombopenia] (PubMed id 9765660)9 NguyA-n P. (1998)
  632. Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes. (PubMed id 9702994)9 Fareed J....Bick R. (1998)
  633. In vivo platelet and T-lymphocyte activities during pulmonary tuberculosis. (PubMed id 9877494)9 BA1yA1kaA9ik Y....DA1ndar S.V. (1998)
  634. Fundamentals of coagulation and glycoprotein IIb/IIIa receptor inhibition. (PubMed id 9539494)9 Ferguson J.J....Wilson J.M. (1998)
  635. Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids. (PubMed id 9465307)9 Modi W.S. and Chen Z.Q. (1998)
  636. Soluble P-selectin is released from activated platelets in vivo during hemodialysis. (PubMed id 9496730)9 Kawabata K....Makino H. (1998)
  637. [Heparin induced thrombocytopenia] (PubMed id 9728258)9 Brenske M. and Tarnow J. (1998)
  638. Evaluation of platelet damage in two different centrifugal pumps based on measurements of alpha-granule packing proteins. (PubMed id 9609343)9 Mohara J....Fuse K. (1998)
  639. The role of epidermal growth factor in platelet-endothelium interactions. (PubMed id 9670106)9 Lukaszyk A....Bielawiec M. (1998)
  640. Association between carotid atherosclerosis and hemostatic markers in patients with cerebral small artery disease. (PubMed id 9607119)9 Nomura E....Nakamura S. (1998)
  641. In vitro effects of the platelet glycoprotein IIb/III a receptor antagonist c7E3 Fab on the activated clotting time. (PubMed id 9024148)9 Ammar T....Coller B.S. (1997)
  642. Chemokine antagonists that discriminate between interleukin-8 receptors. Selective blockers of CXCR2. (PubMed id 9195914)9 Jones S.A....Baggiolini M. (1997)
  643. [Evaluation of platelet function and tissue plasminogen activator activity in ischemic heart disease depending on concurrence with hyperlipoproteinemia and aspirin therapy] (PubMed id 9640079)9 Jastrzebska M....CheA8stowski K. (1997)
  644. Platelet damage caused by the centrifugal pump: in vitro evaluation by measuring the release of alpha-granule packing proteins. (PubMed id 9335369)9 Kawahito K....Fuse K. (1997)
  645. [The influence of multiple dialyzer reuse on selected coagulation parameters] (PubMed id 9190637)9 JuA_wiuk J....Pawlak K. (1997)
  646. Molecular modeling of interleukin-8 receptor beta and analysis of the receptor-ligand interaction. (PubMed id 9464567)9 Luo Z....Huang Z. (1997)
  647. Modulation of blood cell activation by four commonly used anticoagulants. (PubMed id 9134644)9 Engstad C.S....Osterud B. (1997)
  648. [The role of the endothelium in angiogenesis] (PubMed id 10756725)9 Dobrescu G. (1997)
  649. Effects of estrogen replacement therapy on thrombin generation. (PubMed id 9058493)9 Pinto S....Abbate R. (1997)
  650. Biochemical markers of coagulation activation in mitr al stenosis, atrial fibrillation, and cardiomyopathy. (PubMed id 8994731)9 Ikeda U....Shimada K. (1997)
  651. The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence. (PubMed id 9047370)9 Malkowski M.G....Edwards B.F. (1997)
  652. A natural motif approach to protein design: a synthet ic leucine zipper peptide mimics the biological function of the platelet factor 4 protein. (PubMed id 9202142)9 Butcher D.J....Huang Z. (1997)
  653. Coagulation and fibrinolysis system in aortic surgery under deep hypothermic circulatory arrest with aprotinin: the importance of adequate heparinization. (PubMed id 9386127)9 Okita Y....Kawashima Y. (1997)
  654. Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. (PubMed id 9423790)9 Gresele P....DavA- G. (1997)
  655. Specific binding of the chemokine platelet factor 4 to heparan sulfate. (PubMed id 9252363)9 Stringer S.E. and Gallagher J.T. (1997)
  656. Recognition and management of heparin-induced thrombocytopenia (HIT) and thrombosis. (PubMed id 9469632)9 Alving B.M. and Krishnamurti C. (1997)
  657. Expression of prostacyclin receptor in human megakaryocytes. (PubMed id 9242534)9 Sasaki Y....Nakao K. (1997)
  658. Apyrase, ascorbic acid and aprotinin ameliorate the storage lesion in pelleted platelet preparations. (PubMed id 9408586)9 Mrowiec Z.R....Puszkin E.G. (1997)
  659. Application of argatroban, direct thrombin inhibitor, in heparin-intolerant patients requiring extracorporeal circulation. (PubMed id 9288875)9 Matsuo T....Kario K. (1997)
  660. Diagnosis of heparin-induced thrombocytopenia in the vascular surgery patient. (PubMed id 9122872)9 Jackson M.R....Alving B.M. (1997)
  661. Structure and bioactivity of recombinant human CTAP-III and NAP-2. (PubMed id 9055206)9 Proudfoot A.E....Wells T.N. (1997)
  662. Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization. (PubMed id 9166836)9 Kikuchi J....Miura Y. (1997)
  663. [Angiogenesis and antitumor therapy] (PubMed id 9409948)9 Ferrara F....Puricelli S. (1997)
  664. Heparin-induced thrombocytopenia as an autoimmune disease--idiotypic evidence for the role of anti-heparin/PF4 autoantibodies. (PubMed id 9347871)9 Shoenfeld Y. (1997)
  665. Absence of cross-reactivity of SR90107A/ORG31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia. (PubMed id 9518042)9 Amiral J....Meyer D. (1997)
  666. Direct thrombin inhibitors in cardiovascular disease. (PubMed id 9211051)9 Catella-Lawson F. (1997)
  667. Endothelial markers in diabetes mellitus. (PubMed id 8983126)9 Galajda P....Kubisz P. (1997)
  668. Postburn edema and related changes in interleukin-2, leukocytes, platelet activation, endothelin-1, and C1 esterase inhibitor. (PubMed id 9095417)9 Kowal-Vern A....Gamelli R.L. (1997)
  669. Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin. (PubMed id 9158107)9 Blank M....Shoenfeld Y. (1997)
  670. An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. (PubMed id 9207209)9 Doi T.... Imanishi T. (1997)
  671. Interaction of a new depolymerized holothurian glycosaminoglycan with proteins in human plasma. (PubMed id 8840467)9 Minamiguchi K....Kitazato K. (1996)
  672. Erythromelalgia in essential thrombocythemia is characterized by platelet activation and endothelial cell damage but not by thrombin generation. (PubMed id 8883266)9 van Genderen P.J....Michiels J.J. (1996)
  673. [Blood coagulation disorders observed in arteriosclerosis obliterans] (PubMed id 8808808)9 Ishimaru S. (1996)
  674. [Changes in platelet activity in invasive cardiologic procedures] (PubMed id 8768288)9 MalA1 J....JebavA1 L. (1996)
  675. RANTES and macrophage inflammatory protein 1 alpha selectively enhance immunoglobulin (IgE) and IgG4 production by human B cells. (PubMed id 8642352)9 Kimata H....Furusho K. (1996)
  676. Thromboembolic diseases: biochemical mechanisms and new possibilities of biological diagnosis. (PubMed id 8807728)9 Amiral J. and Fareed J. (1996)
  677. [Dysmegakaryocytopoiesis and thrombopoiesis in autoimmune thrombocytopenias] (PubMed id 9074719)9 Bellucci S. (1996)
  678. Effect of different dialysis membranes on platelet function. A tool for biocompatibility evaluation. (PubMed id 8841854)9 De Sanctis L.B....Buttazzi R. (1996)
  679. Alterations in platelet function in patients receiving interleukin-6 as cytokine therapy. (PubMed id 8689424)9 Oleksowicz L....Dutcher J.P. (1996)
  680. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)9 Loetscher M.... Moser B. (1996)
  681. In vitro comparison of the effects of contrast media on coagulation and platelet activation. (PubMed id 8899149)9 Corot C....Sabattier V. (1996)
  682. Restoration of the normal coagulation process: advanc es in therapies to antagonize heparin. (PubMed id 8938285)9 D'Ambra M. (1996)
  683. Effects of sodium ozagrel on hemostatic markers and cerebral blood flow in lacunar infarction. (PubMed id 8937792)9 Oishi M....Takasu T. (1996)
  684. Characteristics of vasospastic angina with exercised-induced ischemia--analysis of parameters of hemostasis and fibrinolysis. (PubMed id 8803721)9 Sakata K....Takada A. (1996)
  685. A recipe for designing water-soluble, beta-sheet-forming peptides. (PubMed id 8819163)9 Mayo K.H....Park H. (1996)
  686. Reversible inhibition by protamine of human synovial and rabbit platelet secretory phospholipase A2. (PubMed id 8679688)9 Emadi S....Hatmi M. (1996)
  687. Induction of inhibitory activity for B cell different iation in human CD8 T cells with pokeweed mitogen, dimaprit, and cAMP upregulat ing agents: countersuppressive effect of platelet factor 4. (PubMed id 8964082)9 Crisi G.M....Thorbecke G.J. (1996)
  688. Effect of defibrotide on platelet function. (PubMed id 8807724)9 Ulutin O.N....Yardimci T. (1996)
  689. Plasma levels of molecular markers of blood coagulation and fibrinolysis in progressive systemic sclerosis (PSS). (PubMed id 8785174)9 Maeda M....Mori S. (1996)
  690. Effect of spirapril and hydrochlorothiazide on platelet function and euglobulin clot lysis time in patients with mild hypertension. (PubMed id 8873580)9 Gleerup G....Winther K. (1996)
  691. Species specific immunoassays to measure blood platelet and coagulation activation in the rat. (PubMed id 8972036)9 Ravanat C....Cazenave J.P. (1996)
  692. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1. (PubMed id 8625964)9 Legler D.F....Moser B. (1996)
  693. Blood clotting in minimally altered whole blood. (PubMed id 8896408)9 Rand M.D....Mann K.G. (1996)
  694. Platelets stored in a glucose-free additive solution or in autologous plasma--an ultrastructural and morphometric evaluation. (PubMed id 8837351)9 Klinger M.H....KlA1ter H. (1996)
  695. [Positive and negative regulation of megakaryocytopoi esis] (PubMed id 9074717)9 Bellucci S....Caen J.P. (1996)
  696. Macrophage-stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family. (PubMed id 8695717)9 Broxmeyer H.E....Leonard E.J. (1996)
  697. Effects of basophil-priming and stimulating cytokines on histamine release from isolated human skin mast cells. (PubMed id 8844126)9 Nitschke M....Amon U. (1996)
  698. Generation of antibodies to heparin-PF4 complexes without thrombocytopenia in patients treated with unfractionated or low-molecular-weight heparin. (PubMed id 8638647)9 Amiral J....Meyer D. (1996)
  699. Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor. (PubMed id 8962720)9 Yoshida A....Zetter B.R. (1996)
  700. Quality of pooled platelet concentrates prepared from buffy coats and stored in an additive solution after filtration. (PubMed id 7880932)9 Koerner K....Kubanek B. (1995)
  701. The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. (PubMed id 7790818)9 Luster A.D....Leder P. (1995)
  702. Thromboxane B2 blood levels and incipient system clotting in heparin free hemodialysis. (PubMed id 7640422)9 Keller F....Meinhold H. (1995)
  703. Platelet function and fibrinolytic activity during rest and exercise in borderline hypertensive patients. (PubMed id 7601202)9 Gleerup G....Winther K. (1995)
  704. Heparin-induced thrombocytopenia and thrombosis. (PubMed id 9372019)9 Visentin G.P. and Aster R.H. (1995)
  705. Bacteria/blood/material interactions. I. Injected and preseeded slime-forming Staphylococcus epidermidis in flowing blood with biomaterials. (PubMed id 7622530)9 Brunstedt M.R....Anderson J.M. (1995)
  706. Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species. (PubMed id 8589212)9 Ravanat C....Legrand C. (1995)
  707. A comprehensive hematologic study in calves with total artificial hearts. (PubMed id 8573803)9 Harasaki H....Massiello A. (1995)
  708. A study of platelet functions, some hemostatic and fibrinolytic parameters in relation to serotonin in hemodialyzed patients under erythropoietin therapy. (PubMed id 7740505)9 Malyszko J....Buczko W. (1995)
  709. Effect of circulating epinephrine on platelet functio n and hematocrit. (PubMed id 7737722)9 Kjeldsen S.E....Julius S. (1995)
  710. Antibodies to macromolecular platelet factor 4-hepari n complexes in heparin-induced thrombocytopenia: a study of 44 cases. (PubMed id 7740492)9 Amiral J....Meyer D. (1995)
  711. Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. (PubMed id 7723894)9 Mezzano S....Mezzano D. (1995)
  712. Effects of beraprost sodium, a new prostaglandin I2 analog, on parameters of hemostasis, fibrinolysis, and myocardial ischemia in patients with exertional angina. (PubMed id 8547211)9 Sakata K....Takada A. (1995)
  713. [Effect of rantes (regulated on activation, normal T expressed and secreted) on eosinophil adhesion to plasma coated glass using eosinophilic cell line (EoL-1)] (PubMed id 7541195)9 Kakazu T....Nakajima S. (1995)
  714. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. (PubMed id 7706245)9 Malkowski M.G.... Edwards B.F.P. (1995)
  715. Platelet and coagulation factor variations induced in vitro by polyethylene terephthalate (Dacron) coated with pyrolytic carbon. (PubMed id 8580259)9 Cenni E....Pizzoferrato A. (1995)
  716. [Lipoprotein(a) and hemostasis activation markers in angina pectoris] (PubMed id 7656834)9 Tsakiris D.A....Marbet G.A. (1995)
  717. Characteristic biological features of human megakaryoblastic leukaemia cell lines. (PubMed id 7564468)9 Hassan H.T. and Freund M. (1995)
  718. Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. (PubMed id 7545174)9 Aronica S.M....Broxmeyer H.E. (1995)
  719. The role of CXC chemokines as regulators of angiogenesis. (PubMed id 8574748)9 Strieter R.M....Kunkel S.L. (1995)
  720. The three-dimensional solution structure of RANTES. (PubMed id 7542919)9 Chung C.-W.... Wells T.N.C. (1995)
  721. Platelet activation and fibrinolysis in large bowel cancer. (PubMed id 7637955)9 Abbasciano V....Zavagli G. (1995)
  722. Anti-inflammatory activity of an orally active peptid e sequence from PF-4 on acute inflammation and DTH. (PubMed id 8548397)9 Talmadge J.E....Counts D.F. (1995)
  723. [Changes in platelet function in patients with arterial hypertension] (PubMed id 7571480)9 MalA1 J....JebavA1 L. (1995)
  724. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation. (PubMed id 7639692)9 Barella L.... Moser B. (1995)
  725. Fibrinolysis profiles and platelet activation after endothelial cell seeding of prosthetic vascular grafts. (PubMed id 8746831)9 Smyth J.V....Walker M.G. (1995)
  726. A mapping study of 13 genes on human chromosome bands 4q11-->q25. (PubMed id 7698025)9 Chen C.S....Kersey J.H. (1995)
  727. Calcium supplementation attenuates an enhanced platel et function in salt-loaded mildly hypertensive patients. (PubMed id 7607719)9 Saito K....Yokoyama M. (1995)
  728. Importance of PF4 in heparin-induced thrombocytopenia: confirmation with gray platelets. (PubMed id 7858274)9 Horne M.K. and Alkins B.R. (1995)
  729. Platelet function and fibrinolytic activity in hypertensive and normotensive sleep apnea patients. (PubMed id 7610315)9 RAYngemark C....Winther K. (1995)
  730. [The effect of indobufen on platelet function and dia lyzer regeneration in patients on hemodialysis] (PubMed id 7491347)9 SokoA8owska B....Walter-Croneck A. (1995)
  731. Migraine--a haematological disorder? (PubMed id 8685625)9 MalA1 J....BlA!ha M. (1995)
  732. Neutralization of heparin activity by neutrophil lactoferrin. (PubMed id 7811995)9 Wu H.F....Church F.C. (1995)
  733. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. (PubMed id 7592998)9 Strieter R.M....Marriott D. (1995)
  734. IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. (PubMed id 7593232)9 Majumdar A....Seidman M.M. (1995)
  735. [Effect of cytokine RANTES on induction of activated eosinophils] (PubMed id 8583714)9 Kakazu T....Nakajima S. (1995)
  736. ARIC hemostasis study--IV. Intraindividual variabilit y and reliability of hemostatic factors. The Atherosclerosis Risk in Communitie s (ARIC). (PubMed id 7792740)9 Nguyen N.D....Wu K.K. (1995)
  737. Cellular interactions in tissue factor expression by blood monocytes. (PubMed id 7544163)9 Osterud B. (1995)
  738. Thrombin generation as an acute effect of cigarette smoking. (PubMed id 8017287)9 Kimura S....Shimada K. (1994)
  739. Heparin-coated oxygenators significantly reduce conta ct system activation in an in vitro cardiopulmonary bypass model. (PubMed id 7865672)9 Wendel H.P....Hoffmeister H.E. (1994)
  740. RANTES- and interleukin-8-induced responses in normal human eosinophils: effects of priming with interleukin-5. (PubMed id 7515718)9 Schweizer R.C....Koenderman L. (1994)
  741. Functional and ligand binding specificity of the rabbit neutrophil IL-8 receptor. (PubMed id 8133060)9 Thomas K.M....Navarro J. (1994)
  742. Angiogenesis: an update. (PubMed id 7534514)9 DA-az-Flores L....Varela H. (1994)
  743. Effect of two lipid emulsions on platelet function. (PubMed id 7803993)9 Porta I....Schwartz S. (1994)
  744. Platelet aggregation, coronary artery disease progression and future coronary events. (PubMed id 8109546)9 Lam J.Y....Waters D. (1994)
  745. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators. (PubMed id 7923645)9 (1994)
  746. Differential binding of chemokines to glycosaminoglycan subpopulations. (PubMed id 7922353)9 Witt D.P. and Lander A.D. (1994)
  747. Increased heparin-releasable platelet factor 4 and D dimer in patients one month after the onset of acute myocardial infarction: persistent activation of platelets and the coagulation/fibrinolytic system. (PubMed id 7737755)9 Abe S....Atsuchi Y. (1994)
  748. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. (PubMed id 8276799)9 Loetscher M....Moser B. (1994)
  749. Different effects of strenuous exercise and moderate exercise on platelet function in men. (PubMed id 7994833)9 Wang J.S....Chen H.I. (1994)
  750. The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. (PubMed id 8077676)9 Paolini J.F....Krangel M.S. (1994)
  751. Effects of hypoxia on platelet activation in pilots. (PubMed id 7945133)9 Shen D. and Wang Y. (1994)
  752. Absence of a prothrombotic state in restenotic patients? (PubMed id 7952409)9 Brack M.J....Gershlick A.H. (1994)
  753. Biocompatibility of heparin-coated membrane oxygenato r during cardiopulmonary bypass. (PubMed id 7887827)9 Hatori N....Tanaka S. (1994)
  754. Effect of atrial fibrillation on the fibrino-coagulation system--study in patients with paroxysmal atrial fibrillation. (PubMed id 7807680)9 Sohara H. and Miyahara K. (1994)
  755. Heparin-coated cardiopulmonary bypass circuits: hemos tatic alterations and postoperative blood loss. (PubMed id 7944696)9 Wagner W.R....Marrone G.C. (1994)
  756. [Relationship of mitral valve area to hemostatic condition in rheumatic mitral stenosis] (PubMed id 7932073)9 Kataoka H....Mikuriya Y. (1994)
  757. Chemokines, inflammation and the immune system. (PubMed id 7584498)9 Taub D.D. and Oppenheim J.J. (1994)
  758. [The effect of quantum hemotherapy on the plasma hemostatic indices and fibrinolysis in patients with unstable angina] (PubMed id 7831873)9 BabiA- L.N....Nikandrova N.L. (1994)
  759. Fish oils and their possible role in the treatment of cardiovascular diseases. (PubMed id 7938179)9 Semplicini A. and Valle R. (1994)
  760. Effects of interleukin-2 administration on platelet function in cancer patients. (PubMed id 8296793)9 Oleksowicz L....Dutcher J.P. (1994)
  761. Plasma beta-thromboglobulin and platelet factor 4 are not increased in insulin-dependent diabetic patients with microalbuminuria. (PubMed id 7827349)9 Gruden G....Pagano G. (1994)
  762. Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4. (PubMed id 8193358)9 Kelton J.G....Horsewood P. (1994)
  763. Beta-thromboglobulin (beta tg) and platelet factor 4 (PF4) in patients with myeloproliferative diseases. (PubMed id 7710537)9 Fabris F....Cella G. (1994)
  764. Expression of the Duffy antigen in K562 cells. Evidence that it is the human erythrocyte chemokine receptor. (PubMed id 8132497)9 Chaudhuri A....Horuk R. (1994)
  765. [Evaluation of platelet hemostasis in patients with chronic renal failure] (PubMed id 7975649)9 Krawczyk W....SokoA8owska B. (1994)
  766. Coagulation and inhibitory and fibrinolytic proteins in essential hypertension. (PubMed id 8400086)9 Vaziri N.D....Neutel J.M. (1993)
  767. The impact of static work on fibrinolysis and platele t function. (PubMed id 8303686)9 Vind J....Winther K. (1993)
  768. [Other mediators of inflammation and sepsis] (PubMed id 8469893)9 Lamy M....Damas P. (1993)
  769. Development of a rapid and sensitive chromogenic hepa rin assay for clinical use. (PubMed id 8477906)9 Wagenvoord R.J....Hemker H.C. (1993)
  770. Altered platelet function associated with the bronchi al hyperresponsiveness accompanying nocturnal asthma. (PubMed id 8473678)9 Gresele P....Nenci G.G. (1993)
  771. Plasma parameters of the prothrombotic state in chronic uremia. (PubMed id 8446263)9 Sagripanti A....Barsotti G. (1993)
  772. Single-dose effect of enteric-coated aspirin on platelet function and thromboxane generation in middle-aged men. (PubMed id 8477113)9 Mohri H. and Ohkubo T. (1993)
  773. Comparative effects of suppressive cytokines on isolated single CD34(3+) stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum. (PubMed id 7691634)9 Lu L....Broxmeyer H.E. (1993)
  774. Cigarette-smoking affects platelets and endothelium i n chronic hemodialysis patients. (PubMed id 8341380)9 Davis J.W....Wiegmann T. (1993)
  775. Study of platelet function in patients with sickle cell anemia during steady state and vaso-occlusive crisis. (PubMed id 8212998)9 Papadimitriou C.A....Lali P. (1993)
  776. Cationic proteins induce airway hyperresponsiveness dependent on charge interactions. (PubMed id 8385431)9 Coyle A.J....Irvin C.G. (1993)
  777. Are megakaryocytes and endothelial cells sisters? (PubMed id 8505591)9 Han Z.C. and Caen J.P. (1993)
  778. Some relations between light transmission changes and biochemical parameters of stored platelet packs. (PubMed id 8259559)9 JAoremo P....Kutti J. (1993)
  779. [Vascular function parameters in idiopathic and quartz-induced progressive scleroderma] (PubMed id 8276590)9 Haustein U.F....Krusche U. (1993)
  780. Map of seven polymorphic markers on rat chromosome 14: linkage conservation with human chromosome 4. (PubMed id 8431642)9 Remmers E.F....Wilder R.L. (1993)
  781. Further evidence that alpha-granule components such as platelet factor 4 are involved in platelet-IgG-heparin interactions during heparin-associated thrombocytopenia. (PubMed id 8236153)9 Gruel Y....Wautier J.L. (1993)
  782. Inherited abnormalities in platelet organelles and platelet formation and associated altered expression of low molecular weight guanosine triphosphate-binding proteins in the mouse pigment mutant gunmetal. (PubMed id 8490171)9 Swank R.T....Novak E.K. (1993)
  783. Nicotine effects on eicosanoid formation and hemostatic function: comparison of transdermal nicotine and cigarette smoking. (PubMed id 7691912)9 Benowitz N.L....Zhang Q. (1993)
  784. Numerical and functional modifications in platelets induced by polyester coated by a hydrophilic polymer. (PubMed id 8399951)9 Cenni E....Pizzoferrato A. (1993)
  785. Melanoma growth-stimulatory activity/GRO decreases collagen expression by human fibroblasts. Regulation by C-X-C but not C-C cytokines. (PubMed id 8419336)9 Unemori E.N....Horuk R. (1993)
  786. Hemostasis variables in type I diabetic patients without demonstrable vascular complications. (PubMed id 8375244)9 el Khawand C....Buysschaert M. (1993)
  787. Continuous intravenous dosing with ciprostene using a portable pump in ambulatory patients. (PubMed id 8440764)9 Wolf D.L....Luderer J.R. (1993)
  788. Platelet activation and fibrinopeptide formation in pulmonary hypertension. (PubMed id 8252943)9 Schulman L.L....Owen J. (1993)
  789. Platelet hyperactivation in patients with essential thrombocythemia is not associated with vascular endothelial cell damage as judged by the level of plasma thrombomodulin, protein S, PAI-1, t-PA and vWF. (PubMed id 8128427)9 Bellucci S....Boffa M.C. (1993)
  790. Evaluation of risk of thrombosis during use of low-dose ethinylestradiol-desogestrel oral contraceptive. (PubMed id 8237574)9 Massafra C....Colombini G. (1993)
  791. Platelet alpha-granules. (PubMed id 8467233)9 Harrison P. and Cramer E.M. (1993)
  792. [The antithrombogenic properties of the vascular wall and platelet aggregation in patients with atherosclerosis of the arteries of the lower extremities following a course of treatment with UV-irradiated autologous blood transfusion] (PubMed id 8020715)9 Adamchik A.S....Belov I.u.V. (1993)
  793. Platelet aggregability in patients with a VVI pacemaker. (PubMed id 7680451)9 Fazio S....Sacca L. (1993)
  794. Interaction of immobilised unfractionated and LMW heparins with proteins in whole human plasma. (PubMed id 8165617)9 Zammit A....Dawes J. (1993)
  795. Human platelets secrete chemotactic activity for eosinophils. (PubMed id 8417801)9 Burgers J.A....Akkerman J.W. (1993)
  796. The effect of low dose nitroglycerin on plasma heparin concentrations and activated partial thromboplastin times. (PubMed id 8457649)9 Brack M.J....Gershlick A.H. (1993)
  797. The platelet functions in stroke. (PubMed id 8599071)9 KrajA-ckovA! D....Pecka M. (1993)
  798. Clinical experience using the Bio-pump for extracorporeal circulation during open-heart surgery. (PubMed id 8338437)9 Yada I....Shimpo H. (1993)
  799. Alpha granule proteins in type I von Willebrand's disease. (PubMed id 8438875)9 McKeown L.P....Gralnick H.R. (1993)
  800. [Alterations of hemostatic markers in elderly patient with atrial fibrillation without a history of stroke] (PubMed id 8331832)9 Kanda A....Terashi A. (1993)
  801. Alcohol-induced protein folding transitions in platel et factor 4: the O-state. (PubMed id 8357808)9 Yang Y. and Mayo K.H. (1993)
  802. [The structural and functional classification and evolution of cytokines] (PubMed id 7688623)9 Zav'ialov V.P. (1993)
  803. Effect of low molecular weight aliphatic alcohols and related compounds on platelet factor 4 subunit association. (PubMed id 8486623)9 Yang Y....Mayo K.H. (1993)
  804. Purification, receptor binding analysis, and biological characterization of human melanoma growth stimulating activity (MGSA). Evidence for a novel MGSA receptor. (PubMed id 8380167)9 Horuk R....Unemori E. (1993)
  805. Mode of interaction between platelet factor 4 and heparin. (PubMed id 8358152)9 Maccarana M. and Lindahl U. (1993)
  806. Iloprost reduces procoagulant activity in the extraco rporeal circuit. (PubMed id 7692141)9 Korn R.L....Addonizio V.P. (1993)
  807. Human platelet factor 4 is a direct inhibitor of huma n osteoblast-like osteosarcoma cell growth. (PubMed id 1520309)9 Tatakis D.N. (1992)
  808. The melanoma growth stimulatory activity receptor consists of two proteins. Ligand binding results in enhanced tyrosine phosphorylation. (PubMed id 1729365)9 Cheng Q.C....Richmond A. (1992)
  809. Ticlopidine and platelet function in healthy voluntee rs. (PubMed id 1615496)9 Dembinska-Kiec A....Sinzinger H. (1992)
  810. Investigation of how different filters affect some bi ochemical properties of stored platelet concentrates. (PubMed id 1499695)9 JAoremo P. and Kutti J. (1992)
  811. Interaction between histidine-rich glycoprotein and platelet factor 4 with dermatan sulfate and low-molecular-weight dermatan sulfate. (PubMed id 1554154)9 Cella G....Terribile V.I. (1992)
  812. Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers. (PubMed id 1514169)9 Krulder J.W....Meinders A.E. (1992)
  813. Racial differences in coagulation studies in stroke. (PubMed id 1355861)9 Gaines K.J....Cape C. (1992)
  814. Modulation of eosinophil chemotaxis by interleukin-5. (PubMed id 1449809)9 Warringa R.A....Koendermann L. (1992)
  815. Anticardiolipin antibodies and coronary heart disease. (PubMed id 1289095)9 Tsakiris D.A....Duckert F. (1992)
  816. Indobufen versus dipyridamole plus aspirin in the treatment of patients with peripheral atherosclerotic disease. (PubMed id 1512524)9 Fabris F....Girolami A. (1992)
  817. Spontaneous in vitro megakaryocyte colony formation in primary thrombocythemia: relation to platelet factor 4 plasma level and beta-thromboglobulin/platelet factor 4 ratio. (PubMed id 1386487)9 Abgrall J.F....BriA"re J. (1992)
  818. Association between high levels of growth factors in plasma and progression of coronary atherosclerosis. (PubMed id 1453123)9 Nilsson J....Hamsten A. (1992)
  819. Circadian variation in platelet function in healthy volunteers. (PubMed id 1532287)9 Jafri S.M....Goldstein S. (1992)
  820. Evidence for a storage pool defect in platelets from cirrhotic patients with defective aggregation. (PubMed id 1386051)9 Laffi G....Nenci G.G. (1992)
  821. Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4. (PubMed id 1316786)9 Tunnacliffe A....Poncz M. (1992)
  822. [Clinical and experimental study of Ligusticum wallichii and aspirin in the treatment of transient ischemic attack] (PubMed id 1301850)9 Chen D.R. (1992)
  823. Control of angiogenesis by heparin and other sulfated polysaccharides. (PubMed id 1279952)9 Folkman J. and Shing Y. (1992)
  824. Biological risk factors for sudden death in patients with coronary artery disease and without heart failure. (PubMed id 1563856)9 Lauribe P....Bricaud H. (1992)
  825. Studies on the effect of dopamine on the human platel et response. (PubMed id 1382907)9 Anfossi G....Trovati M. (1992)
  826. Reduced platelet thromboxane formation after long-term administration of a dihydropyridine calcium channel blocker: a prospective, double-blind, placebo-controlled study with nitrendipine in borderline hypertensive patients with IDDM-type diabetes mellitus. (PubMed id 1286547)9 Tschoepe D....Gries F.A. (1992)
  827. Prophylactic antithrombin III administration during pregnancy immediately reduces the thrombin hyperactivity of congenital antithrombin III deficiency by forming thrombin-antithrombin III complexes. (PubMed id 1523607)9 Kario K....Matsuo M. (1992)
  828. Megakaryocytic leukemia and platelet factor 4. (PubMed id 1337850)9 Ryo R....Yamaguchi N. (1992)
  829. [Effect of lovastatin on platelet function in hypercholesterolemic patients] (PubMed id 1300548)9 DmoszyA+ska A....SokoA8owska B. (1992)
  830. Thrombosis in spinal cord injury. (PubMed id 1290164)9 Fujii Y....Weingarden S.T. (1992)
  831. Connective tissue-activating peptide-III and its deri vative, neutrophil-activating peptide-2, release histamine from human basophils . (PubMed id 1372016)9 Reddigari S.R....Kaplan A.P. (1992)
  832. [Atherosclerosis: the risk factors] (PubMed id 1493667)9 Buschini M....Zenone F. (1992)
  833. Induction of transient neurological dysfunction in baboons by platelet microemboli. (PubMed id 1533737)9 Kessler C....Harker L.A. (1992)
  834. Neutralization of the anticoagulant effects of glycosaminoglycans by serum amyloid P component: comparison with other plasma and platelet proteins. (PubMed id 1377216)9 Williams E.C....Asakura S. (1992)
  835. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. (PubMed id 1514184)9 Amiral J....Meyer D. (1992)
  836. Detection of platelet-specific protein mRNAs in different megakaryoblasts using the reverse transcriptase polymerase chain reaction. (PubMed id 1493450)9 Yasunaga M....Yamaguchi N. (1992)
  837. Interleukin-8, a chemotactic and inflammatory cytokine. (PubMed id 1639201)9 Baggiolini M. and Clark-Lewis I. (1992)
  838. The acute effect of smoking on platelet and endothelial release reaction is suppressed in chronic smokers. (PubMed id 1533735)9 Ozdemir O....Kirazli S. (1992)
  839. Reduction in factor VII, fibrinogen and plasminogen activator inhibitor-1 activity after surgical treatment of morbid obesity. (PubMed id 1448769)9 Primrose J.N....Johnston D. (1992)
  840. Markers for endothelial injury, clotting and platelet activation in preeclampsia. (PubMed id 1605673)9 Saleh A.A....Mammen E.F. (1992)
  841. [A clinical study on hemostatic fluctuation during and after cardiopulmonary bypass using hemostatic molecular markers] (PubMed id 1336789)9 Nakajima H. (1992)
  842. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. (PubMed id 1418604)9 Miller M.D. and Krangel M.S. (1992)
  843. Characterization of GRO alpha, beta and gamma expression in human colonic tumours: potential significance of cytokine involvement. (PubMed id 1341267)9 Cuenca R.E....Haskill S. (1992)
  844. Platelet activation and vascular damage in gestational hypertension. (PubMed id 1531575)9 Ballegeer V.C....Criel A.M. (1992)
  845. Increased levels of tissue plasminogen activator (t-PA) and tissue plasminogen activator inhibitor (PAI) correlate with tumor necrosis factor alpha (TNF alpha)-release in patients suffering from microangiopathy following allogeneic bone marrow transplantation (BMT). (PubMed id 1412203)9 Seeber C....Kolb H.J. (1992)
  846. [Effect of molsidomine infusion on thrombocyte function in acute myocardial infarct] (PubMed id 1837969)9 Hiller E....Riess H. (1991)
  847. Properties of the novel proinflammatory supergene 'intercrine' cytokine family. (PubMed id 1910690)9 Oppenheim J.J....Matsushima K. (1991)
  848. Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates. (PubMed id 1835678)9 Gruber A....Griffin J.H. (1991)
  849. Heparin-releasable platelet factor 4 in patients with coronary artery disease. (PubMed id 1835913)9 Sadayasu T....Kuroiwa A. (1991)
  850. Hemobiological activity of gliclazide in diabetes mellitus. (PubMed id 1794271)9 Ziegler O. and Drouin P. (1991)
  851. Platelet function during antihypertensive treatment w ith quinapril, a novel angiotensin converting enzyme inhibitor. (PubMed id 1708046)9 Gupta R.K....Julius S. (1991)
  852. [Adenine nucleotides in migraine] (PubMed id 1931099)9 Leira R....Noya M. (1991)
  853. Coagulation disorders and tumor markers in the diagnosis of pancreatic cancer. (PubMed id 1720884)9 Abbasciano V....Zavagli G. (1991)
  854. Platelet-derived growth factor mesangial deposits in mesangial IgA glomerulonephritis. (PubMed id 2057110)9 Nakajima M....Kincaid-Smith P. (1991)
  855. Platelet activation, endothelial cell dysfunction in the absence of anticardiolipin antibodies in systemic sclerosis. (PubMed id 1839040)9 Lima J....PicA^ M. (1991)
  856. Relationship of platelet specific proteins and other factors to atherosclerosis in various stages of hypertension. (PubMed id 1836985)9 Ding Y.A....Lin K.C. (1991)
  857. [Effects of Ligusticum wallichii on the plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2 and 6-keto-PGF1 alpha in patients with acute cerebral infarction] (PubMed id 1840363)9 Liu Z. (1991)
  858. Platelet survival in patients with dilated cardiomyopathy. (PubMed id 1839090)9 Weidinger F....Sinzinger H. (1991)
  859. Heparin released platelet factor 4 in uncomplicated t ype 1 diabetes mellitus. (PubMed id 1896971)9 Cella G. and Paolini R. (1991)
  860. The effects of diet and insulin therapy on coagulation factor VII, blood viscosity, and platelet release proteins in diabetic patients with secondary sulphonylurea failure. (PubMed id 1830258)9 Jennings A.M....Ward J.D. (1991)
  861. [Relation of coronary heart disease based on traditional Chinese medicine syndrome differentiation and prostaglandin, blood platelet function, and protein C] (PubMed id 1831734)9 Guo X.C. (1991)
  862. Storage of platelets in a new plastic container. Polyvinyl chloride plasticized with butyryl-n-trihexyl citrate. (PubMed id 1807058)9 Gulliksson H....UdAcn A.M. (1991)
  863. Platelet function and fibrinolytic activity in hypertension: differential effects of calcium antagonists and beta-adrenergic receptor blockers. (PubMed id 1725542)9 Winther K....Hedner T. (1991)
  864. [Thromboxane, prostacyclin and platelet factor 4 in patients with atrial fibrillation] (PubMed id 1942987)9 Panchenko V.M....Zhivoderov V.M. (1991)
  865. [Anti-heparin activity of plasma with various low density lipoprotein content] (PubMed id 1669184)9 Worowski K....Skrzydlewski Z. (1991)
  866. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). (PubMed id 2012010)9 Qureshi A.A....Peterson D.M. (1991)
  867. [Experimental and clinical study of activated platelet in allergic asthma] (PubMed id 1806336)9 Yu H.P....Li P.S. (1991)
  868. Platelet factor 4 mRNA expression in cells from a patient with megakaryoblastic crisis of chronic myelogenous leukemia. (PubMed id 1991266)9 Ryo R....Yokoyama M. (1991)
  869. Correlation of aggregometry responses to changes in light transmission through platelet packs. (PubMed id 1891765)9 JAoremo P....Berseus O. (1991)
  870. Neurite outgrowth in dorsal root neuronal hybrid clones modulated by ganglioside GM1 and disintegrins. (PubMed id 1825296)9 Barletta E....Culp L.A. (1991)
  871. Alterations of platelet function induced by interleukin-2. (PubMed id 1790144)9 Oleksowicz L....Holland J.F. (1991)
  872. Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia. (PubMed id 1877038)9 Wedzicha J.A....Tan K.C. (1991)
  873. Hirudin--a potential stabilizing factor for platelet preservation in transfusion. (PubMed id 1832654)9 Pindur G....Braun B. (1991)
  874. Interleukin 8-inhibitor and inducer of histamine and leukotriene release in human basophils. (PubMed id 1715699)9 Bischoff S.C....Dahinden C.A. (1991)
  875. Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. (PubMed id 1926064)9 Domoto D.T....Joist J.H. (1991)
  876. Effects of taprostene, a stable prostacyclin analogue, on haemodynamics, platelet function and arachidonate metabolism in healthy volunteers. (PubMed id 2111774)9 Virgolini I....Barth H. (1990)
  877. Changes in hemostasis activity during delivery and the immediate postpartum period. (PubMed id 2140236)9 Gerbasi F.R....Mammen E.F. (1990)
  878. Dipyridamole specifically decreases platelet-derived growth factor release from platelets. (PubMed id 2150573)9 Takehara K....Ishibashi Y. (1990)
  879. Reference values of hemostasis related factors of healthy Japanese adults. I: Circadian fluctuation. (PubMed id 2087689)9 Akiyama Y....Suzuki S. (1990)
  880. [Studies on the intraglomerular distribution of fibronectin in IgA nephropathy--in relation to clinical pictures and prognosis] (PubMed id 2198363)9 Urae M. (1990)
  881. Global and molecular hemostatic markers in acute myeloid leukemia. (PubMed id 2220667)9 Reddy V.B....Schumacher H.R. (1990)
  882. Hemodynamic, platelet and clinical responses to prostacyclin in unstable angina pectoris. (PubMed id 2109927)9 ThAcroux P....Waters D. (1990)
  883. Regulation of megakaryocyte phenotype in human erythroleukemia cells. (PubMed id 2318965)9 Long M.W....Prochownik E.V. (1990)
  884. A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. (PubMed id 2189406)9 Ohmori Y. and Hamilton T.A. (1990)
  885. [Beta-thromboglobulin and platelet factor 4 in a follow-up of acute myelofibrosis (megakaryoblastic leukemia)] (PubMed id 2146451)9 Palomera Bernal L. and GarcA-a DA-ez I. (1990)
  886. Clonal segregation of multiple and overlapping matrix adhesive responses in dorsal root neuronal derivative cells. (PubMed id 2332451)9 Barletta E. and Culp L.A. (1990)
  887. In vitro thromboxane synthesis of depleted blood platelets following renal transplantation. (PubMed id 2148845)9 Scharf R.E. (1990)
  888. Thrombin generation is not increased in the blood of hemophilia B patients after the infusion of a purified factor IX concentrate. (PubMed id 2265248)9 Mannucci P.M....Rosenberg R.D. (1990)
  889. [Hormonal profile and changes in platelet aggregation in menstrual migraine] (PubMed id 2100130)9 Leira R....Noya M. (1990)
  890. Platelet responses to intravenous infusion of Intralipid in healthy volunteers. (PubMed id 2144940)9 Jarnvig I.L....Wilhjelm B. (1990)
  891. Dose-dependent effects of verapamil and nifedipine on in vivo platelet function in normal volunteers. (PubMed id 2147908)9 Winther K....Hedner T. (1990)
  892. [Disorders of blood platelet homeostasis in patients with multiple myeloma before the treatment and during remission] (PubMed id 2092326)9 DmoszyA8ska-Giannopoulou A....SokoA8owska B. (1990)
  893. Clinical effects of a polyethylene glycol grafted cellulose membrane on thrombogenicity and biocompatibility during hemodialysis. (PubMed id 2252772)9 Akizawa T....Imamura K. (1990)
  894. Beta-TG and plasma catecholamines levels after sympathetic stimuli in hypertensives and patients with peripheral vascular disease. (PubMed id 2144920)9 Catalano M....Libretti A. (1990)
  895. Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily. (PubMed id 1967588)9 Modi W.S....O'Brien S.J. (1990)
  896. Sustained-release nifedipine (nifedipine-L) suppresses plasma thromboxane B2 and 6-keto prostaglandin F1 alpha in both young male smokers and nonsmokers. (PubMed id 2353613)9 Nakashima Y....Kuroiwa A. (1990)
  897. Identification of a novel platelet-derived neutrophil-chemotactic polypeptide with structural homology to platelet-factor 4. (PubMed id 2241978)9 SchrAPder J.M....Christophers E. (1990)
  898. Effect of disulfiram on the platelet function and fibrinolysis in healthy volunteers. (PubMed id 1700758)9 Gleerup G....Winther K. (1990)
  899. [Megakaryocytic leukemia cell lines and megakaryocytic leukemia] (PubMed id 2381077)9 Ryo R....Yamaguchi N. (1990)
  900. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. (PubMed id 1699135)9 Schall T.J....Goeddel D.V. (1990)
  901. [Platelet function study in primary Raynaud's phenomenon and Raynaud's phenomenon associated with scleroderma] (PubMed id 2151867)9 Cuenca R....Vilardell M. (1990)
  902. Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin. (PubMed id 2294999)9 Jakubowski J.A. and Maraganore J.M. (1990)
  903. Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome. (PubMed id 2136815)9 Grande P....Madsen J.K. (1990)

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Entrez Gene: 5196 HGNC: 8861 AceView: PF4 Ensembl:ENSG00000163737 euGenes: HUgn5196
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PF4
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 Regulatory tfbs in PF4 promoter
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 RT2 qPCR Primer Assay in human, mouse, rat PF4
 GNC Network for PF4
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 Search Tocris compounds for PF4 (PLF4)
 Proteins and Antibodies for PF4
 Browse Sino Biological Cell Lysates
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for PF4
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 Recombinant Protein for PF4




 Proteins for PF4
 Antibodies for PF4
 ELISAs for PF4
 CLIAs for PF4
 Search LifeMap BioReagents cell lines for PF4
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4
 SwitchGear 3'UTR luciferase reporter plasmids for PF4
 SwitchGear Promoter luciferase reporter plasmids for PF4
 ThermoFisher Antibodies for PF4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PF4
 inGenious Targeting Laboratory - Custom generated mouse model solutions for PF4
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PF4
Customized:
 lentivirus for stable overexpression of PF4
 lentivirus expression plasmids for stable overexpression of PF4
 adenovirus for overexpression of PF4
 LSBio Antibodies in human, mouse, rat for PF4
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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