Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PF4 Gene

Aliases for PF4 Gene

  • Platelet Factor 4 2 3
  • Chemokine (C-X-C Motif) Ligand 4 2 3
  • C-X-C Motif Chemokine 4 3 4
  • Oncostatin-A 3 4
  • Iroplact 3 4
  • CXCL4 3 4
  • SCYB4 3 4
  • PF-4 3 4

External Ids for PF4 Gene

Summaries for PF4 Gene

Entrez Gene Summary for PF4 Gene

  • This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

GeneCards Summary for PF4 Gene

PF4 (Platelet Factor 4) is a Protein Coding gene. Diseases associated with PF4 include malaria and essential thrombocythemia. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is CXCL1.

UniProtKB/Swiss-Prot for PF4 Gene

  • Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Gene Wiki entry for PF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PF4 Gene

Genomics for PF4 Gene

Genomic Location for PF4 Gene

Start:
73,980,825 bp from pter
End:
73,982,124 bp from pter
Size:
1,300 bases
Orientation:
Minus strand

Genomic View for PF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PF4 Gene

Regulatory Elements for PF4 Gene

Transcription factor binding sites by QIAGEN in the PF4 gene promoter:

Proteins for PF4 Gene

  • Protein details for PF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02776-PLF4_HUMAN
    Recommended name:
    Platelet factor 4
    Protein Accession:
    P02776
    Secondary Accessions:
    • Q53X61
    • Q9UC64
    • Q9UC65

    Protein attributes for PF4 Gene

    Size:
    101 amino acids
    Molecular mass:
    10845 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for PF4 Gene

neXtProt entry for PF4 Gene

Proteomics data for PF4 Gene at MOPED

Post-translational modifications for PF4 Gene

No Post-translational modifications

Other Protein References for PF4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PF4 Gene

Domains for PF4 Gene

Protein Domains for PF4 Gene

UniProtKB/Swiss-Prot:

PLF4_HUMAN
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.:
    • P02776
genes like me logo Genes that share domains with PF4: view

No data available for Gene Families for PF4 Gene

Function for PF4 Gene

Molecular function for PF4 Gene

GENATLAS Biochemistry: platelet factor 4 (see IMC2@)
UniProtKB/Swiss-Prot Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Gene Ontology (GO) - Molecular Function for PF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity TAS 12466273
GO:0008201 heparin binding IDA 9531587
GO:0048248 CXCR3 chemokine receptor binding IDA 12782716
genes like me logo Genes that share ontologies with PF4: view

Phenotypes for PF4 Gene

genes like me logo Genes that share phenotypes with PF4: view

Animal Models for PF4 Gene

MGI Knock Outs for PF4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PF4 Gene

Localization for PF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PF4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PF4 Gene COMPARTMENTS Subcellular localization image for PF4 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
lysosome 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with PF4: view

Pathways for PF4 Gene

genes like me logo Genes that share pathways with PF4: view

Gene Ontology (GO) - Biological Process for PF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with PF4: view

Compounds for PF4 Gene

(1) Drugbank Compounds for PF4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Drotrecogin alfa
  • Anticoagulant protein C
60202-16-6 target

(114) Novoseek inferred chemical compound relationships for PF4 Gene

Compound -log(P) Hits PubMed IDs
heparin 87.7 298
danaparoid 84.1 2
hirudin 80.3 5
fibrinopeptide a 75.6 8
txb2 75.1 60
genes like me logo Genes that share compounds with PF4: view

Transcripts for PF4 Gene

mRNA/cDNA for PF4 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PF4 Gene

Platelet factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PF4 Gene

No ASD Table

Relevant External Links for PF4 Gene

GeneLoc Exon Structure for
PF4
ECgene alternative splicing isoforms for
PF4

Expression for PF4 Gene

mRNA expression in normal human tissues for PF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PF4 Gene

This gene is overexpressed in Whole Blood (44.9) and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PF4 Gene

SOURCE GeneReport for Unigene cluster for PF4 Gene Hs.81564

genes like me logo Genes that share expressions with PF4: view

Orthologs for PF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PF4 36
  • 99.01 (n)
  • 98.02 (a)
PF4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PF4 36
  • 78.08 (n)
  • 71.23 (a)
PF4 37
  • 57 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pf4 36
  • 79.22 (n)
  • 75.32 (a)
Pf4 16
Pf4 37
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 38 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 39 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pf4 36
  • 78.35 (n)
  • 74.03 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
OneToMany
Species with no ortholog for PF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PF4 Gene

ENSEMBL:
Gene Tree for PF4 (if available)
TreeFam:
Gene Tree for PF4 (if available)

Paralogs for PF4 Gene

Paralogs for PF4 Gene

Selected SIMAP similar genes for PF4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PF4: view

Variants for PF4 Gene

Sequence variations from dbSNP and Humsavar for PF4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4694 -- 73,981,270(-) GGAAG(A/G)AAAAT synonymous-codon, reference
rs352004 -- 73,980,853(-) TATTA(C/T)CTTTG utr-variant-3-prime, downstream-variant-500B
rs352005 -- 73,980,911(-) ATTCA(C/T)GCATT utr-variant-3-prime, downstream-variant-500B
rs352006 -- 73,981,160(-) TACTT(C/T)TTTTT utr-variant-3-prime
rs352007 -- 73,981,575(+) GAGGA(C/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PF4 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Relevant External Links for PF4 Gene

HapMap Linkage Disequilibrium report
PF4

Disorders for PF4 Gene

(4) University of Copenhagen DISEASES for PF4 Gene

(94) Novoseek inferred disease relationships for PF4 Gene

Disease -log(P) Hits PubMed IDs
thrombocytopenia 85.4 115
thrombosis 75.6 51
abnormal platelets 61.3 2
thromboembolism 60.5 3
megakaryoblastic leukemia acute 60.5 2

Relevant External Links for PF4

Genetic Association Database (GAD)
PF4
Human Genome Epidemiology (HuGE) Navigator
PF4
genes like me logo Genes that share disorders with PF4: view

No data available for UniProtKB/Swiss-Prot for PF4 Gene

Publications for PF4 Gene

  1. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PMID: 1695112) Eisman R. … Poncz M. (Blood 1990) 3 4 23
  2. Crystal structure of recombinant human platelet factor 4. (PMID: 8031770) Zhang X. … Maione T.E. (Biochemistry 1994) 3 4 23
  3. NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N- terminal chimera: a symmetric tetramer. (PMID: 7547867) Mayo K.H. … Daly T.J. (Biochemistry 1995) 3 4 23
  4. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. (PMID: 1688470) Maione T.E. … Sharpe R.J. (Science 1990) 3 23
  5. Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor. (PMID: 7524669) Brown K.J. … Parish C.R. (Biochemistry 1994) 3 23

Products for PF4 Gene

Sources for PF4 Gene

Back to Top

Content