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PF4 Gene

protein-coding   GIFtS: 62
GCID: GC04M074836

Platelet Factor 4

(Previous name: platelet factor 4)
  See PF4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Platelet Factor 41 2     C-X-C Motif Chemokine 42 3
Chemokine (C-X-C Motif) Ligand 41 2     iroplact2
CXCL42 3     oncostatin-A2
PF-42 3     Iroplact3
SCYB42 3     Oncostatin-A3

External Ids:    HGNC: 88611   Entrez Gene: 51962   Ensembl: ENSG000001637377   OMIM: 1734605   UniProtKB: P027763   

Export aliases for PF4 gene to outside databases

Previous GC identifers: GC04M075086 GC04M075247 GC04M075313 GC04M075211 GC04M070658


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PF4 Gene:
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of
activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet
aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of
hematopoiesis, angiogenesis and T-cell function. (provided by RefSeq, Mar 2012)

GeneCards Summary for PF4 Gene:
PF4 (platelet factor 4) is a protein-coding gene. Diseases associated with PF4 include intermediate coronary syndrome, and sneddon syndrome. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds
more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for
neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor
than the longer form

Gene Wiki entry for PF4 (Platelet factor 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PF4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPF4 promoter sequence
   Search Chromatin IP Primers for PF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q21

PF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PF4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074836:  view genomic region     (about GC identifiers)

Start:
74,846,794 bp from pter      End:
74,847,841 bp from pter
Size:
1,048 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776 (See protein sequence)
Recommended Name: Platelet factor 4 precursor  
Size: 101 amino acids; 10845 Da
Subunit: Homotetramer
Mass spectrometry: Mass=7765; Method=Electrospray; Range=32-101; Source=PubMed:7644496;
Mass spectrometry: Mass=6033; Method=Electrospray; Range=48-101; Note=Short form; Source=PubMed:7644496;
Selected PDB 3D structures from and Proteopedia for PF4 (see all 7):
1DN3 (3D)        1F9Q (3D)        1F9R (3D)        1F9S (3D)        1PFM (3D)        1PFN (3D)    
Secondary accessions: Q53X61 Q9UC64 Q9UC65

Explore the universe of human proteins at neXtProt for PF4: NX_P02776

Explore proteomics data for PF4 at MOPED


See PF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002610.1  
ENSEMBL proteins: 
 ENSP00000296029  
Reactome Protein details: P02776

PF4 Human Recombinant Protein Products:

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Novus Biologicals PF4 Lysates
Sino Biological Recombinant Protein for PF4
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ProSpec Recombinant Protein for PF4
Cloud-Clone Corp. Proteins for PF4

 
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Cloud-Clone Corp. ELISAs for PF4
Cloud-Clone Corp. CLIAs for PF4
Search eBioscience for ELISAs for PF4 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR027222 PF4
 IPR001811 Chemokine_IL8-like_dom
 IPR001089 Chemokine_CXC
 IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P02776

ProtoNet protein and cluster: P02776

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: PLF4_HUMAN, P02776
Similarity: Belongs to the intercrine alpha (chemokine CxC) family


Find genes that share domains with PF4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PLF4_HUMAN, P02776
Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds
more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for
neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor
than the longer form

     Genatlas biochemistry entry for PF4:
platelet factor 4 (see IMC2@)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity TAS12466273
GO:0008201heparin binding IDA9531587
GO:0048248CXCR3 chemokine receptor binding IDA12782716
     
Find genes that share ontologies with PF4           About GenesLikeMe


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pf4):
 hematopoietic system  homeostasis/metabolism 

Find genes that share phenotypes with PF4           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Pf4tm1Mako for PF4

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PF4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PF4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PF4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PF4

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat PF4

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PF4

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PLF4_HUMAN, P02776: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytoskeleton1
lysosome1
nucleus1
plasma membrane1
vacuole1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0031093platelet alpha granule lumen TAS--

Find genes that share ontologies with PF4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PF4 About   (see all 14)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
IL-6 Pathway0.61
MIF Mediated Glucocorticoid Regulation0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
3Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
4Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44
5Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90


Find genes that share SuperPaths with PF4           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for PF4
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PF4 (see all 17)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Transendothelial Migration of Leukocytes
MIF Mediated Glucocorticoid Regulation

1 BioSystems Pathway for PF4
    CXCR3-mediated signaling events


5 Reactome Pathways for PF4
    Platelet degranulation
Chemokine receptors bind chemokines
G alpha (i) signalling events
Cell surface interactions at the vascular wall
Common Pathway


2 Kegg Pathways  (Kegg details for PF4):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including PF4 (see all 8): 
          Endothelial Cell Biology in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Angiogenesis in human mouse rat

Interactions:

    GeneGlobe Interaction Network for PF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PF4 (P027762, 3 ENSP000002960294) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
InteractantInteraction Details
GeneCardExternal ID(s)
IL8P101453, ENSP000003065124I2D: score=3 STRING: ENSP00000306512
PROCP040703, ENSP000002340714I2D: score=2 STRING: ENSP00000234071
SRGNP101243, ENSP000002424654I2D: score=2 STRING: ENSP00000242465
CXCL12P480613, ENSP000003635484I2D: score=1 STRING: ENSP00000363548
CCL5P135013, ENSP000002932724I2D: score=2 STRING: ENSP00000293272
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Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002576platelet degranulation TAS--
GO:0006955immune response IEA--
GO:0007596blood coagulation TAS--
GO:0010628positive regulation of gene expression IDA10666185
GO:0010744positive regulation of macrophage derived foam cell differentiation IDA17244792

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PF4 (PLF4)

1 DrugBank Compound for PF4    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Drotrecogin alfaAnticoagulant protein C (see all 4)60202-16-6target--11259926

Selected Novoseek inferred chemical compound relationships for PF4 gene (see all 114)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
heparin 87.7 940 8282825 (7), 17257993 (6), 8857955 (6), 1537108 (6) (see all 99)
danaparoid 84.1 2 18983520 (1), 16109780 (1)
hirudin 80.3 7 16404704 (1), 9024148 (1), 18541684 (1), 1832654 (1) (see all 5)
fibrinopeptide a 75.6 11 7646626 (2), 7539015 (2), 7637955 (1), 1720884 (1) (see all 6)
txb2 75.1 95 8329704 (5), 1840363 (3), 10475099 (3), 15613179 (2) (see all 46)
fondaparinux 72.6 12 18262226 (3), 9518042 (1), 15317404 (1), 16359523 (1) (see all 10)
rantes 68.4 87 15459010 (9), 15899984 (5), 19201759 (3), 7531729 (3) (see all 38)
fibrinogen 67.9 72 17351162 (3), 8996302 (2), 11077138 (2), 7553675 (2) (see all 50)
tecogalan sodium 65.4 2 9409948 (1), 10439927 (1)
adp 65.1 49 7843648 (3), 12889011 (3), 9863147 (2), 11782701 (2) (see all 30)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PF4 gene: 
NM_002619.3  

Unigene Cluster for PF4:

Platelet factor 4
Hs.81564  [show with all ESTs]
Unigene Representative Sequence: NM_002619
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000296029(uc003hhi.2)
miRNA
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  QuantiFast Probe-based Assays in human, mouse, rat PF4

Additional mRNA sequence: 

BC093965.1 BC112093.1 CR407677.1 M25897.1 

2 DOTS entries:

DT.113152  DT.121223983 

Selected AceView cDNA sequences (see all 30):

AI078445 CR407677 BQ023965 N92470 AI739539 NM_002619 T28407 AJ705588 
AA024823 AA152486 BX114245 M25897 AI185569 T84282 W17158 AI766542 
CA426108 BV177626 AA024929 T85166 AI400188 AI470327 R83715 AA152485 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PF4 Expression
About this image


PF4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 10) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 3 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Mesenchymal Condensate Cells Zeugopod
         Bone Marrow
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Medulla Oblongata
 
 Neural Crest (Gastrulation Derivatives)
         Cranial Neural Crest Cells Branchial Arch 1
 
 Cartilage (Muscoskeletal System)
         Mesenchymal Condensate Cells Zeugopod
PF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PF4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.81564
    Pathway & Disease-focused RT2 Profiler PCR Arrays including PF4 (see all 8): 
          Endothelial Cell Biology in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Angiogenesis in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for PF4
OriGene qSTAR qPCR primer pairs in human, mouse for PF4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PF4
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QuantiFast Probe-based Assays in human, mouse, rat PF4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PF4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PF4 gene from 8 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia PF41 platelet factor 4 99.01(n)
98.02(a)
  740477  XM_001155980.3  XP_001155980.1 
mouse
(Mus musculus)
Mammalia Pf41 , 5 platelet factor 41, 5 79.22(n)1
75.32(a)1
  5 (44.78 cM)5
567441  NM_019932.41  NP_064316.11 
 907724355 
rat
(Rattus norvegicus)
Mammalia Pf41 platelet factor 4 78.35(n)
74.03(a)
  360918  NM_001007729.1  NP_001007730.1 
cow
(Bos taurus)
Mammalia PF41 platelet factor 4 78.08(n)
71.23(a)
  507790  NM_001101062.1  NP_001094532.1 
oppossum
(Monodelphis domestica)
Mammalia --
Uncharacterized protein
38(a)
1 → many
5(21327456-21330596)
platypus
(Ornithorhynchus anatinus)
Mammalia --
--
(see all 3)
Uncharacterized protein
(see all 3)
44(a)
39(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
Ultra362(665218-670940)
Contig34660(3809-5082)
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
33(a)
1 → many
4(50379773-50381069)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
32(a)
1 → many
6(60123888-60134622)
        Species with no ortholog for PF4

ENSEMBL Gene Tree for PF4 (if available)
TreeFam Gene Tree for PF4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PF4 gene
PPBP2  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
9 SIMAP similar genes for PF4 using alignment to 1 protein entry:     PLF4_HUMAN:
PF4V1    PPBP    CXCL5    CXCL10    CXCL6    CXCL1
CXCL2    IL8    CXCL3

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PF4 (see all 121)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1478434171,2
--74724385(+) CCAACA/GTATTC 1 -- ds50010--------
rs1116657401,2
C,F--74724455(+) GAGATG/ATGACA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs1839965631,2
--74724474(+) AGAGGC/TTGGAG 1 -- ds50010--------
rs1887704001,2
--74724524(+) AGAACA/GTAGAT 1 -- ds50010--------
rs1502871851,2
--74724631(+) CCCACC/TTGGGA 1 -- ds50010--------
rs1124443471,2
C--74724797(+) AAAAA-/CATCATCA 1 -- cds11Minor allele frequency- CAT:0.50CSA 2
rs3520041,2
C,F,O,H--74724908(-) TATTAC/TCTTTG 1 -- ut3126Minor allele frequency- T:0.12MN NS EA NA WA CSA 2514
rs1448896531,2
--74724938(+) TGTAGA/CTATAA 1 -- ut310--------
rs3520051,2
C,F,O,H--74724966(-) ATTCAT/CGCATT 1 -- ut3114Minor allele frequency- C:0.09MN NA NS EA WA 912
rs115744521,2
C,F,H--74724999(-) GTTATG/TCTTGG 1 -- ut3119Minor allele frequency- T:0.07NA NS EA 2466

HapMap Linkage Disequilibrium report for PF4 (74846794 - 74847841 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PF4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv525980CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PF4
DNA2.0 Custom Variant and Variant Library Synthesis for PF4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 173460    OMIM disorders: --

12 diseases for PF4:    
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intermediate coronary syndrome    sneddon syndrome    erythromelalgia    acute poststreptococcal glomerulonephritis
iga glomerulonephritis    learning disability    polycythemia vera    hemophilia b
tuberculosis    atherosclerosis    myocardial infarction    malaria

4 diseases from the University of Copenhagen DISEASES database for PF4:
Thrombocytopenia     Vascular disease     Heart disease     Myeloma

Find genes that share disorders with PF4           About GenesLikeMe

Selected Novoseek inferred disease relationships for PF4 gene (see all 94)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thrombocytopenia 85.4 191 8282825 (3), 12753876 (3), 17495129 (3), 10938877 (2) (see all 99)
thrombosis 75.6 75 14764524 (3), 20004006 (3), 9002937 (3), 8282825 (2) (see all 38)
abnormal platelets 61.3 2 2141791 (1), 1931099 (1)
thromboembolism 60.5 6 11827497 (1), 11442479 (1), 19521017 (1)
megakaryoblastic leukemia acute 60.5 2 1337850 (1), 1493450 (1)
thrombocytosis 59.9 10 2140694 (2), 1826402 (1), 10086090 (1), 16462666 (1) (see all 6)
thrombophilia 58.4 2 11342462 (1), 16766786 (1)
thrombocythemia essential 51.3 4 1386487 (1), 16138352 (1), 15352995 (1), 16977569 (1)
platelet aggregation, spontaneous 48.8 3 1692679 (1), 8870174 (1)
erythromelalgia 46.9 5 16138352 (2), 12781799 (1), 8883266 (1)

Genetic Association Database (GAD): PF4
Human Genome Epidemiology (HuGE) Navigator: PF4 (10 documents)

Export disorders for PF4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PF4 gene, integrated from 10 sources (see all 919):
(articles sorted by number of sources associating them with PF4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. (PubMed id 1695112)1, 2, 9 Eisman R.... Poncz M. (Blood 1990)
  2. Localization of distal regulatory domains in the megakaryocyte- specific platelet basic protein/platelet factor 4 gene locus. (PubMed id 11468158)1, 2, 9 Zhang C.... Reilly M.P. (Blood 2001)
  3. NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N- terminal chimera: a symmetric tetramer. (PubMed id 7547867)1, 2, 9 Mayo K.H.... Daly T.J. (Biochemistry 1995)
  4. Crystal structure of recombinant human platelet factor 4. (PubMed id 8031770)1, 2, 9 Zhang X.... Maione T.E. (Biochemistry 1994)
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
  9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5196 HGNC: 8861 AceView: PF4 Ensembl:ENSG00000163737 euGenes: HUgn5196
ECgene: PF4 Kegg: 5196 H-InvDB: PF4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PF4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PF4 Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/CXCL4

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PF4 gene:
Search GeneIP for patents involving PF4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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