Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PEX5L Gene

Aliases for PEX5L Gene

  • Peroxisomal Biogenesis Factor 5-Like 2 3
  • PEX5R 3 4 6
  • Tetratricopeptide Repeat-Containing Rab8b-Interacting Protein 3 4
  • Peroxisome Biogenesis Factor 5-Like 3 4
  • Peroxin-5-Related Protein 3 4
  • PEX2-Related Protein 3 4
  • PEX5-Like Protein 3 4
  • PEX5RP 3 4
  • TRIP8b 3 4
  • PXR2B 3 6
  • PXR2 3 4
  • Pex5p-Related Protein 3
  • PEX5-Related Protein 3

External Ids for PEX5L Gene

Summaries for PEX5L Gene

GeneCards Summary for PEX5L Gene

PEX5L (Peroxisomal Biogenesis Factor 5-Like) is a Protein Coding gene. GO annotations related to this gene include small GTPase binding and peroxisome matrix targeting signal-1 binding. An important paralog of this gene is PEX5.

UniProtKB/Swiss-Prot for PEX5L Gene

  • Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEX5L Gene

Genomics for PEX5L Gene

Genomic Location for PEX5L Gene

Start:
179,794,958 bp from pter
End:
180,037,053 bp from pter
Size:
242,096 bases
Orientation:
Minus strand

Genomic View for PEX5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PEX5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEX5L Gene

Regulatory Elements for PEX5L Gene

Proteins for PEX5L Gene

  • Protein details for PEX5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB4-PEX5R_HUMAN
    Recommended name:
    PEX5-related protein
    Protein Accession:
    Q8IYB4
    Secondary Accessions:
    • B7Z2A5
    • B7Z305
    • B7Z318
    • B7Z5Z5
    • B7Z8P2
    • E7EUV8
    • E7EUZ0
    • E9PEC1
    • E9PH97
    • Q9NQD1
    • Q9P2U3
    • Q9P2U4

    Protein attributes for PEX5L Gene

    Size:
    626 amino acids
    Molecular mass:
    69697 Da
    Quaternary structure:
    • Interacts with RAB8B. Forms an obligate 4:4 complex with HCN2 (By similarity). May interact with the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type); the relevance of such interaction is however unclear.
    SequenceCaution:
    • Sequence=CAC01120.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PEX5L Gene

neXtProt entry for PEX5L Gene

Proteomics data for PEX5L Gene at MOPED

Post-translational modifications for PEX5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PEX5L Gene

Domains for PEX5L Gene

Gene Families for PEX5L Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for PEX5L Gene

UniProtKB/Swiss-Prot:

PEX5R_HUMAN
Family:
  • Belongs to the peroxisomal targeting signal receptor family.:
    • Q8IYB4
Similarity:
  • Contains 6 TPR repeats.:
    • Q8IYB4
genes like me logo Genes that share domains with PEX5L: view

Function for PEX5L Gene

Molecular function for PEX5L Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.

Gene Ontology (GO) - Molecular Function for PEX5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000268 peroxisome targeting sequence binding IDA 18346465
GO:0005052 peroxisome matrix targeting signal-1 binding IDA 11463335
GO:0005515 protein binding --
GO:0031267 small GTPase binding IPI 18346465
genes like me logo Genes that share ontologies with PEX5L: view
genes like me logo Genes that share phenotypes with PEX5L: view

Animal Models for PEX5L Gene

MGI Knock Outs for PEX5L:

miRNA for PEX5L Gene

miRTarBase miRNAs that target PEX5L

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PEX5L Gene

Localization for PEX5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEX5L Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Some fraction is membrane associated via its interaction with RAB8B. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEX5L Gene COMPARTMENTS Subcellular localization image for PEX5L gene
Compartment Confidence
cytosol 3
nucleus 3
peroxisome 3
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PEX5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005778 peroxisomal membrane IBA --
GO:0005829 cytosol IDA 11463335
GO:0030425 dendrite IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with PEX5L: view

Pathways for PEX5L Gene

SuperPathways for PEX5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for PEX5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016558 protein import into peroxisome matrix IBA --
GO:0016560 protein import into peroxisome matrix, docking IBA --
GO:0042391 regulation of membrane potential IEA --
GO:0043949 regulation of cAMP-mediated signaling ISS --
GO:0045185 maintenance of protein location IEA --
genes like me logo Genes that share ontologies with PEX5L: view

No data available for Pathways by source for PEX5L Gene

Transcripts for PEX5L Gene

Unigene Clusters for PEX5L Gene

Peroxisomal biogenesis factor 5-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PEX5L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -

Relevant External Links for PEX5L Gene

GeneLoc Exon Structure for
PEX5L
ECgene alternative splicing isoforms for
PEX5L

Expression for PEX5L Gene

mRNA expression in normal human tissues for PEX5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEX5L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.3), Brain - Substantia nigra (6.0), Brain - Frontal Cortex (BA9) (5.9), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Hippocampus (5.2), and Brain - Cortex (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PEX5L Gene

SOURCE GeneReport for Unigene cluster for PEX5L Gene Hs.235331

mRNA Expression by UniProt/SwissProt for PEX5L Gene

Q8IYB4-PEX5R_HUMAN
Tissue specificity: Mainly expressed in brain. Also expressed in pancreas, testis and pituitary.
genes like me logo Genes that share expressions with PEX5L: view

Orthologs for PEX5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PEX5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PEX5L 36
  • 97.8 (n)
  • 97.58 (a)
PEX5L 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PEX5L 36
  • 90.27 (n)
  • 95.27 (a)
PEX5L 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PEX5L 36
  • 93.42 (n)
  • 98.22 (a)
PEX5L 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pex5l 36
  • 87.09 (n)
  • 95.29 (a)
Pex5l 16
Pex5l 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PEX5L 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PEX5L 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pex5l 36
  • 88.43 (n)
  • 96.68 (a)
chicken
(Gallus gallus)
Aves PEX5L 36
  • 79.01 (n)
  • 84.78 (a)
PEX5L 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PEX5L 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pex5l 36
  • 72.46 (n)
  • 73.69 (a)
zebrafish
(Danio rerio)
Actinopterygii PEX5L (2 of 2) 37
  • 57 (a)
OneToMany
pex5la 36
  • 65.69 (n)
  • 65.98 (a)
pex5la 37
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pex5 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea prx-5 37
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 20 (a)
ManyToMany
PEX5 37
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for PEX5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PEX5L Gene

ENSEMBL:
Gene Tree for PEX5L (if available)
TreeFam:
Gene Tree for PEX5L (if available)

Paralogs for PEX5L Gene

Paralogs for PEX5L Gene

Selected SIMAP similar genes for PEX5L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PEX5L: view

Variants for PEX5L Gene

Sequence variations from dbSNP and Humsavar for PEX5L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs800363 -- 179,797,460(-) TATTA(A/C)CCAAA utr-variant-3-prime
rs811652 -- 179,818,091(-) GTCTC(C/T)GATTT intron-variant
rs813354 -- 179,800,266(-) CAACA(A/C)CAACA utr-variant-3-prime
rs939824 -- 180,034,102(+) TAAAT(C/T)AGACT intron-variant
rs939825 -- 180,034,327(+) GCTTA(A/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PEX5L Gene

Variant ID Type Subtype PubMed ID
dgv78n68 CNV Gain 17160897
esv2667315 CNV Deletion 23128226
esv2726258 CNV Deletion 23290073
esv1977016 CNV Deletion 18987734
esv2726259 CNV Deletion 23290073
esv2726260 CNV Deletion 23290073
esv1009120 CNV Deletion 20482838
esv2742991 CNV Deletion 23290073
esv1408102 CNV Deletion 17803354
nsv236140 CNV Loss 16902084
dgv20e24 CNV Loss 17666407
esv2554672 CNV Deletion 19546169
esv2395412 CNV Deletion 18987734
esv2726261 CNV Deletion 23290073
esv2676913 CNV Deletion 23128226
esv1008971 CNV Deletion 20482838
esv8438 CNV Loss 19470904
esv2726262 CNV Deletion 23290073
esv259510 OTHER Complex 20981092
esv33250 CNV Loss 17666407
esv33044 CNV Loss 17666407

Relevant External Links for PEX5L Gene

HapMap Linkage Disequilibrium report
PEX5L

Disorders for PEX5L Gene

(1) University of Copenhagen DISEASES for PEX5L Gene

Relevant External Links for PEX5L

Genetic Association Database (GAD)
PEX5L
Human Genome Epidemiology (HuGE) Navigator
PEX5L
genes like me logo Genes that share disorders with PEX5L: view

No data available for UniProtKB/Swiss-Prot for PEX5L Gene

Publications for PEX5L Gene

  1. Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals. (PMID: 11463335) Amery L. … Van Veldhoven P.P. (Biochem. J. 2001) 2 3 4 23
  2. Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b. (PMID: 18346465) Fransen M. … Van Veldhoven P.P. (Biochim. Biophys. Acta 2008) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 49

Products for PEX5L Gene

Sources for PEX5L Gene

Back to Top

Content