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PEX5 Gene

protein-coding   GIFtS: 60

GC12P007236
peroxisomal biogenesis factor 5
(Previous name: peroxisome receptor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PXR1)
Services    

Aliases &
Descriptions
for PEX5

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ50634 2
FLJ50721 2
FLJ51948 2
PTS1-BP 2, 3
PTS1R 1, 2, 3, 5
PXR1 2, 3, 5
Peroxin-5 3
peroxin-5 2
Descriptions
PTS1 receptor 3
Peroxisomal C-terminal targeting signal import receptor 2, 3
Peroxisome receptor 1 1, 2, 3
peroxisomal biogenesis factor 5 2
peroxisomal targeting signal 1 (SKL type) receptor 2
peroxisomal targeting signal import receptor 2
peroxisomal targeting signal receptor 1 2
External Ids
HGNC: 97191
Entrez Gene: 58302
UniProtKB: P505423
Ensembl: ENSG000001391977
Search outside databases for aliases for PEX5 gene

Previous GC identifer: GC12P007235

Summaries
for PEX5

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for PEX5:
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal
(SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins
that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders
(PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized
by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a
heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being
observed in cases falling into particular complementation groups. Although the clinical features
of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more
classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of
neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a
cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding
different isoforms have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: PEX5_HUMAN, P50542
Function: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and
plays an essential role in peroxisomal protein import

Gene Wiki entry for PEX5

Genomic Location
for PEX5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PEX5 gene  

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p

PEX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007236:     (about GC identifiers)

Start:
 7,234,224 bp from pter
End:
 7,255,343 bp from pter
Size:
 21,120 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000012.10  NT_009714.16  

Proteins
for PEX5

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: PEX5_HUMAN, P50542 (See protein sequence)
Recommended Name: Peroxisomal targeting signal 1 receptor  
Size: 639 amino acids; 70865 Da
Subunit: Interacts with PEX7 and PEX13 (By similarity). Interacts with PEX12 and PEX14
Subcellular location: Cytoplasm. Peroxisome membrane; Peripheral membrane protein. Note=Its
distribution appears to be dynamic. It is probably a cycling receptor found mainly in the
cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13)
PDB structures from and Proteopedia :
1FCH (3D)    2C0L (3D)    2C0M (3D)    2J9Q (3D)    2W84 (3D)    
Secondary accessions: Q15115 Q15266 Q96FN7
Alternative splicing: 3 isoforms:  P50542-1   P50542-2   P50542-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (5 alternative transcripts): 
    NP_000310.2  NP_001124495.1  NP_001124496.1  NP_001124497.1  NP_001124498.1  


    ENSEMBL proteins: 
    ENSP00000266564 ENSP00000379877 ENSP00000266563 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (PEX5)
    Human Recombinant Proteins from Abnova (PEX5)
                  OriGene Purified Recombinant Human Protein: PEX5 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005777 peroxisome IEA--
    GO:0005778 peroxisomal membrane IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for PEX5: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (PEX5), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for PEX5

    Assays for PEX5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for PEX5

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR001440 TPR-1
     IPR013026 TPR_region
     IPR019734 TPR_repeat


       GeneDecks  PEX5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P50542

    ProtoNet protein and cluster: P50542

    UniProtKB/Swiss-Prot: PEX5_HUMAN, P50542
    Similarity: Belongs to the peroxisomal targeting signal receptor family
    Similarity: Contains 7 TPR repeats

    Gene Function
    for PEX5

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (PEX5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (PEX5)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001131023

                  Applied Biosystems Silencer® siRNAs for PEX5

                  Sigma-Aldrich siRNA for PEX5  
                         Sigma-Aldrich shRNA for PEX5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for PEX5
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000319
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000319
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_000319 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001131023

    UniProtKB/Swiss-Prot: PEX5_HUMAN, P50542
    Function: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and
    plays an essential role in peroxisomal protein import

    9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pex5):

    digestive/alimentaryembryogenesisgrowth/sizelethality-postnatalliver/biliary system
    musclenervous systemrenal/urinary systemrespiratory system

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI9653144 10837480
    About this table

    Pathways & Interactions
    for PEX5

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  PEX5 


    5/35 Interacting proteins for PEX5 (P505421, 2 ENSP000002665643) via UniProtKB, MINT, and/or STRING (see all 35 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PEX14O753812, ENSP000003490163MINT-15777 MINT-15776 STRING (score=.999)
    PEX12O006231, 2, ENSP000002258733EBI-597835, EBI-594836 MINT-17392 EBI-597835, EBI-594836 MINT-17392 STRING (score=.999)
    PEX12O006231, 2, ENSP000002258733EBI-597835, EBI-594836 MINT-17392 EBI-597835, EBI-594836 MINT-17392 STRING (score=.999)
    SNUPNO951492MINT-63270
    PEX12O006231, 2, ENSP000002258733EBI-597835, EBI-594836 MINT-17392 EBI-597835, EBI-594836 MINT-17392 STRING (score=.999)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031 protein transport IEA--
    About this table

    Drugs & Compounds
    for PEX5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for PEX5
    7 Novoseek chemical compound relationships for PEX5 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tripeptide 74.44 1 17007944 (1)
    acyl-coa 63.98 1 10462504 (1)
    tripeptide s 49.07 1 9837948 (1)
    asparagine 27.41 1 8769411 (1)
    atp 14.63 2 12456682 (1), 16314507 (1)
    lipid 0.00 1 16849337 (1)
    zinc 0.00 3 10562279 (2)
    About this table


    Transcripts
    for PEX5

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (PEX5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (PEX5)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001131023

                  Sigma-Aldrich siRNA for PEX5  
                         Sigma-Aldrich shRNA for PEX5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000319  NM_001131023  NM_001131024  NM_001131025  NM_001131026  

    REFSEQ mRNAs for PEX5 gene (5 alternative transcripts): 

    NM_000319.4   NM_001131023.1   NM_001131024.1   NM_001131025.1   NM_001131026.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000319  NM_001131023  NM_001131024  NM_001131025  NM_001131026  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000319
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000319
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_000319 

    Additional cDNA sequence: 

    AK225126.1 AK292256.1 AK299105.1 AK299534.1 AK301700.1 AK302742.1 AK303515.1 AK312317.1 
    AK316250.1 BC010621.2 CR606696.1 CR624220.1 U19721.1 X84899.1 Z48054.1 

    6 DOTS entries:

    DT.100817774  DT.95092209  DT.91646130  DT.70105337  DT.121151451  DT.95092229 

    24/176 AceView cDNA sequences (see all 176 ):

    X84899 AL079967 AA351600 AW007243 BI758042 AA738481 W39074 BU617582 
    BX280495 T08345 BM973011 AL561558 Z38232 N68515 BI869282 BQ439128 
    T32266 AW950952 AW073348 AA873073 CR606696 BC010621 AA351578 F01771 

    highest scoring ESTs for PEX5:

    Z48054 AA034224 AA039506 AA039507 AA063632 AA134182 AA134183 AA167780 AA301707 AA351577 

    Unigene Cluster for PEX5:

    Peroxisomal biogenesis factor 5
    Hs.567327  [show with all ESTs]
    Unigene Representative Sequence: NM_001131025


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PEX5

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                -                                                                           
    SP2:                                -                 -                                                         
    SP3:                                -     -                                                                     
    SP4:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for PEX5

    3 Ensembl transcripts including schematic representations:
    ENST00000266564  ENST00000396637  ENST00000266563  

    Expression
    for PEX5

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    PEX5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for PEX5

    1 / 2 / 3

    6 probe-sets matching PEX5 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40151_s_at2, 3 U95-A 1 1.00 1.00 0.91 1.40 Z48054 1.00 1.00 1.00 1

    		40152_r_at2, 3 U95-A 2 1.00 0.97 0.84 0.60 Z48054 1.00 1.00 1.00 1

    		203244_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000319 0.60 1.00 0.82 1

    		215481_s_at2, 3 U133-A 2 1.00 0.91 -- -- AW468717 0.80 1.00 0.91 1

    		203244_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		215481_s_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --
    GeneDecks  PEX5 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTCCCAGGAT

    SOURCE GeneReport for Unigene cluster: Hs.567327

    Expression variation in blood from EXPOLDB for PEX5

    UniProtKB/Swiss-Prot: PEX5_HUMAN, P50542
    Tissue specificity: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and
    pancreas

    Orthologs
    for PEX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for PEX5 gene from 5/18 species (see all 18 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 PEX51   -- peroxisomal biogenesis factor 5 93.56(n)
    97.78(a)    		 486710  XM_543837.2  XP_543837.2 
    chimpanzee
    (Pan troglodytes)    		 PEX51   -- peroxisomal biogenesis factor 5 99.79(n)
    99.84(a)    		 451812  XM_508983.2  XP_508983.2 
    cow
    (Bos taurus)    		 PEX51   -- peroxisomal biogenesis factor 5 90.54(n)
    97.15(a)    		 514832  NM_001046183.1  NP_001039648.1 
    mouse
    (Mus musculus)    		 Pex51, 5 6 (59.60 cM)5
    		 peroxisomal biogenesis factor 51, 5 89.77(n)1
    93.96(a)1    		 193051  NM_008995.21  NP_033021.21 
     AJ4164735  AK0888865  (see all 14)
    chicken
    (Gallus gallus)    		 PEX51   -- peroxisomal biogenesis factor 5 72.69(n)
    79.24(a)    		 418299  NM_001012818.1  NP_001012836.1 
    About this table        Species with no ortholog for PEX5

    ENSEMBL Gene Tree for PEX5

    Paralogs
    for PEX5

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for PEX5 gene
    PEX5L2  

    Pseudogenes
    1 related pseudogene


    SNPs/Variants
    for PEX5

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/141 NCBI SNPs in PEX5 are shown (see all 141 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 51)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs123126411,2
    		A,C,F,H7232261(+) GGGACG/ACCCAA 1 -- ng514Minor allele frequency- A:0.06EU EA WA 418
    rs10572251,2
    		A,C,F,H7254841(+) GGGCTC/GTATTC 4 -- ut31 ese36Minor allele frequency- G:0.39EA MN EU WA 2078
    rs43297481,2
    		A,C,F,H7255709(+) TGTATC/TAAGTG 1 -- ng318Minor allele frequency- T:0.42EU EA WA 838
    rs22902411,2
    		C,F,H,O7232610(-) GCTGCC/TGGTAA 1 -- ng5115Minor allele frequency- T:0.16EA EU WA NA MN 2876
    rs21226571,2
    		A,C,F,H7232818(-) TCCCAC/TCACTC 1 -- ng514Minor allele frequency- T:0.02EU EA WA 420
    rs38164251,2
    		C,F,H7232966(-) CATAAT/CGGGGA 1 -- ng519Minor allele frequency- C:0.03EA MN EU WA 1866
    rs38137371,2
    		C,F7254227(+) ACGTAG/AGGGTG 4 -- ut31 ese31Minor allele frequency- A:0.13EA 930
    --
    rs10571911,2
    		H7252412(+) TGAAAC/TCCTAC 5 T/I mis1 ese34Minor allele frequency- T:0.00EU EA WA 406
    rs123163711,2
    		H7254714(+) GCAGCC/GGTCCT 4 -- ut31 ese34Minor allele frequency- G:0.00EU EA WA 414
    --
    rs124246181,2
    		A,C,F,H7236069(+) aatgcA/Gttatc 1 -- int14Minor allele frequency- G:0.41EU EA WA 412
    About this table

    HapMap Linkage Disequilibrium images for PEX5 (up to first 250kb)

    Disorders & Mutations
    for PEX5

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 600414   disorders: 202370  214100  

    UniProtKB/Swiss-Prot: PEX5_HUMAN, P50542

  • Defects in PEX5 are a cause of adrenoleukodystrophy neonatal (NALD) [MIM:202370]. NALD is
    a peroxisome biogenesis disorder (PBD) characterized by the accumulation of very long-chain fatty
    acids, adrenal insufficiency and mental retardation. Inheritance is autosomal recessive
  • Defects in PEX5 are a cause of Zellweger syndrome (ZWS) [MIM:214100]. ZWS is a fatal
    peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular
    abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia
    and neonatal seizures. Death occurs within the first year of life
  • Defects in PEX5 may be a cause of infantile Refsum disease (IRD) [MIM:266510]. IRD is a
    mild peroxisome biogenesis disorder (PBD). Clinical features include early onset, mental
    retardation, minor facial dysmorphism, retinopathy, sensorineural hearing deficit, hepatomegaly,
    osteoporosis, failure to thrive, and hypocholesterolemia. The biochemical abnormalities include
    accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic
    acid and pipecolic acid

    • 4 Novoseek disease relationships for PEX5 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    peroxisome biogenesis disorders 93.34 6 8670792 (1), 9668159 (1), 18712838 (1), 16314507 (1) (see all 6)
    zellweger syndrome 87.08 7 11583975 (2), 11161709 (1), 11939592 (1), 7790377 (1) (see all 5)
    adrenoleukodystrophy neonatal 79.91 2 8769411 (1), 7790377 (1)
    peroxisomal disorders 77.48 3 8791450 (1), 11161709 (1), 7790377 (1)
    About this table

    GeneTests: PEX5
    Zellweger Syndrome Spectrum

    Human Gene Mutation Database: PEX5

    Medical News
    for PEX5

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for PEX5

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/86 PubMed articles for PEX5 gene (see all 86 ):

    Search for PEX5

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PEX5

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 5830 HGNC: 9719 AceView: PEX5 Ensembl:ENSG00000139197 euGenes: HUgn5830
    ECgene: PEX5 H-InvDB: PEX5

    Other Databases showing PEX5

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing PEX5

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=PEX5

    Licensable Technologies
    for PEX5

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for PEX5

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for PEX5:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PEX5-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for PEX5 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for PEX5 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (PEX5)
     Search for Antibodies
     Chimera RNAi (PEX5)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (PEX5)
     Antibodies (PEX5)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for PEX5




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for PEX5

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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