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Aliases for PERM1 Gene

Aliases for PERM1 Gene

  • PPARGC1 And ESRR Induced Regulator, Muscle 1 2 3
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 And Estrogen-Related Receptor-Induced Regulator In Muscle 1 3 4
  • PPARGC1 And ESRR-Induced Regulator In Muscle 1 3 4
  • C1orf170 3 4
  • PGC-1 And ERR-Induced Regulator In Muscle Protein 1 3
  • PGC-1- And ERR-Induced Regulator In Muscle 1 2
  • PGC-1 And ERR-Induced Regulator In Muscle 1 3
  • Chromosome 1 Open Reading Frame 170 2

External Ids for PERM1 Gene

Previous HGNC Symbols for PERM1 Gene

  • C1orf170

Previous GeneCards Identifiers for PERM1 Gene

  • GC01M000910

Summaries for PERM1 Gene

GeneCards Summary for PERM1 Gene

PERM1 (PPARGC1 And ESRR Induced Regulator, Muscle 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PERM1 Gene

  • Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PERM1 Gene

Genomics for PERM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PERM1 Gene

Start:
975,199 bp from pter
End:
982,093 bp from pter
Size:
6,895 bases
Orientation:
Minus strand

Genomic View for PERM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PERM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PERM1 Gene

No data available for Regulatory Elements for PERM1 Gene

Proteins for PERM1 Gene

  • Protein details for PERM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SV97-PERM1_HUMAN
    Recommended name:
    PGC-1 and ERR-induced regulator in muscle protein 1
    Protein Accession:
    Q5SV97
    Secondary Accessions:
    • Q6ZVZ7
    • Q9BRF2
    • S5G239

    Protein attributes for PERM1 Gene

    Size:
    790 amino acids
    Molecular mass:
    81351 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PERM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PERM1 Gene

Proteomics data for PERM1 Gene at MOPED

Post-translational modifications for PERM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PERM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PERM1 Gene

Domains for PERM1 Gene

Protein Domains for PERM1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PERM1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PERM1 Gene

Function for PERM1 Gene

Molecular function for PERM1 Gene

UniProtKB/Swiss-Prot Function: Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PERM1 Gene

Localization for PERM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PERM1 Gene

Cytoplasm. Nucleus. Note=Shows a nuclear localization in the presence of PPARGC1A. {ECO:0000250 UniProtKB:Q149B8}.

Gene Ontology (GO) - Cellular Components for PERM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with PERM1: view

No data available for Subcellular locations from COMPARTMENTS for PERM1 Gene

Pathways for PERM1 Gene

SuperPathways for PERM1 Gene

No Data Available

Interacting Proteins for PERM1 Gene

Gene Ontology (GO) - Biological Process for PERM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0014850 response to muscle activity IDA 23836911
genes like me logo Genes that share ontologies with PERM1: view

No data available for Pathways by source for PERM1 Gene

Transcripts for PERM1 Gene

mRNA/cDNA for PERM1 Gene

(10) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PERM1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PERM1 Gene

No ASD Table

Relevant External Links for PERM1 Gene

GeneLoc Exon Structure for
PERM1
ECgene alternative splicing isoforms for
PERM1

Expression for PERM1 Gene

mRNA expression in normal human tissues for PERM1 Gene

mRNA differential expression in normal tissues according to GTEx for PERM1 Gene

This gene is overexpressed in Muscle - Skeletal (28.9), Heart - Left Ventricle (15.9), and Heart - Atrial Appendage (5.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PERM1 Gene

mRNA Expression by UniProt/SwissProt for PERM1 Gene

Q5SV97-PERM1_HUMAN
Tissue specificity: Muscle-specific expression is increased by endurance exercise.
genes like me logo Genes that share expressions with PERM1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PERM1 Gene

Orthologs for PERM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PERM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf170 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf170 36
  • 39 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf170 36
  • 44 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310042D19Rik 16
2310042D19Rik 36
  • 39 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf170 36
  • 30 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf170 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf170 36
  • 22 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf170 36
  • 67 (a)
OneToOne
Species with no ortholog for PERM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PERM1 Gene

ENSEMBL:
Gene Tree for PERM1 (if available)
TreeFam:
Gene Tree for PERM1 (if available)

Paralogs for PERM1 Gene

Pseudogenes.org Pseudogenes for PERM1 Gene

genes like me logo Genes that share paralogs with PERM1: view

No data available for Paralogs for PERM1 Gene

Variants for PERM1 Gene

Sequence variations from dbSNP and Humsavar for PERM1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2340595 -- 978,812(-) CCAAG(C/G)AGGGG intron-variant
rs2340596 -- 978,509(-) GAACA(C/T)GGGGC intron-variant
rs2341354 -- 983,193(+) CTCTC(A/G)CATTT upstream-variant-2KB
rs2341355 -- 983,253(+) GGCTG(C/T)GTGGC upstream-variant-2KB
rs3748588 -- 975,721(+) CCAGC(C/T)GGAGT utr-variant-3-prime, nc-transcript-variant

Relevant External Links for PERM1 Gene

HapMap Linkage Disequilibrium report
PERM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PERM1 Gene

Disorders for PERM1 Gene

No disorders were found for PERM1 Gene.

No data available for UniProtKB/Swiss-Prot for PERM1 Gene

Publications for PERM1 Gene

  1. Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC- 1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. (PMID: 23836911) Cho Y. … Kralli A. (J. Biol. Chem. 2013) 2 3 4
  2. A draft map of the human proteome. (PMID: 24870542) Kim M.S. … Pandey A. (Nature 2014) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for PERM1 Gene

Sources for PERM1 Gene

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