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PER3 Gene

protein-coding   GIFtS: 60
GCID: GC01P007844

Period Circadian Clock 3

(Previous names: period (Drosophila) homolog 3, period homolog 3 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Period Circadian Clock 31 2     GIG132
Cell Growth-Inhibiting Gene 13 Protein2 3     Growth-Inhibiting Protein 132
Circadian Clock Protein PERIOD 32 3     Period 32
hPER32 3     Period Circadian Protein 32
Period (Drosophila) Homolog 31     Period Circadian Protein Homolog 32
Period Homolog 3 (Drosophila)1     Period Homolog 32

External Ids:    HGNC: 88471   Entrez Gene: 88632   Ensembl: ENSG000000492467   OMIM: 6034275   UniProtKB: P566453   

Export aliases for PER3 gene to outside databases

Previous GC identifers: GC01P007426 GC01P007653 GC01P007554 GC01P007778 GC01P006993


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PER3 Gene:
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic
nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the
circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL
heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with
CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2014)

GeneCards Summary for PER3 Gene:
PER3 (period circadian clock 3) is a protein-coding gene. Diseases associated with PER3 include delayed sleep phase syndrome, and advanced sleep phase syndrome. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is PER1.

UniProtKB/Swiss-Prot: PER3_HUMAN, P56645
Function: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind
heme

Gene Wiki entry for PER3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PER3 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   CUTL1   POU3F2   NF-kappaB   Roaz   FOXL1   NF-kappaB2   MRF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPER3 promoter sequence
   Search Chromatin IP Primers for PER3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

PER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PER3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P007844:  view genomic region     (about GC identifiers)

Start:
7,844,380 bp from pter      End:
7,905,237 bp from pter
Size:
60,858 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PER3_HUMAN, P56645 (See protein sequence)
Recommended Name: Period circadian protein homolog 3  
Size: 1201 amino acids; 131888 Da
Subunit: Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2,
BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1,
CRY2, and TIMELESS. Interaction with CSNK1D or CSKN1E promotes nuclear location of PER proteins (By similarity)
Sequence caution: Sequence=BAB32925.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5H8X4 Q5H8X5 Q969K6 Q96S77 Q96S78 Q9C0J3 Q9NSP9 Q9UGU8
Alternative splicing: 2 isoforms:  P56645-1   P56645-2   

Explore the universe of human proteins at neXtProt for PER3: NX_P56645

Explore proteomics data for PER3 at MOPED

Post-translational modifications: 

  • Phosphorylation appears to require association with PER1 and translocation to the nucleus (By similarity)1
  • Ubiquitinated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PER3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001276790.1  NP_001276791.1  NP_001276792.1  NP_001276793.1  NP_058515.1  

    ENSEMBL proteins: 
     ENSP00000366764   ENSP00000366755   ENSP00000355031  

    PER3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PER3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PER3
    GenScript Custom Purified and Recombinant Proteins Services for PER3
    Novus Biologicals PER3 Proteins
    Novus Biologicals PER3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PER3

    PER3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PER3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PER3
    OriGene Custom Antibody Services for PER3
    Novus Biologicals PER3 Antibodies
    Abcam antibodies for PER3
    Cloud-Clone Corp. Antibodies for PER3
    Search ThermoFisher Antibodies for PER3
    LSBio Antibodies in human, mouse, rat for PER3

    PER3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PER3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PER3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PER3
    Cloud-Clone Corp. CLIAs for PER3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001610 PAC
     IPR000014 PAS
     IPR022728 Period_circadian-like_C

    Graphical View of Domain Structure for InterPro Entry P56645

    ProtoNet protein and cluster: P56645

    1 Blocks protein domain: IPB001610 PAC motif

    UniProtKB/Swiss-Prot: PER3_HUMAN, P56645
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    PER3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PER3_HUMAN, P56645
    Function: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind
    heme

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI--
         
    PER3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Per3):
     behavior/neurological  nervous system  vision/eye 

    PER3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Per3tm1Drw for PER3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PER3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PER3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PER3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PER3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PER3:
    hsa-mir-21-5p (MIRT030960), hsa-mir-26b-5p (MIRT029909)

    Block miRNA regulation of human, mouse, rat PER3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PER3 (see all 31):
    hsa-miR-3910 hsa-miR-30c hsa-miR-607 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-1257 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidPER3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PER3
    Predesigned siRNA for gene silencing in human, mouse, rat PER3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PER3

    Clone
    Products:
         
    OriGene clones in human, mouse for PER3 (see all 7)
    OriGene ORF clones in mouse, rat for PER3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PER3 (NM_016831)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PER3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PER3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PER3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PER3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PER3_HUMAN, P56645: Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Translocates to
    the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    PER3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PER3 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian rhythm
    Circadian rhythm0.31
    Circadian Clock in Mammals0.31
    2Circadian entrainment
    Circadian entrainment0.40
    3Influenza A
    Herpes simplex infection0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PER3
        Circadian Clock in Mammals


    3 Kegg Pathways  (Kegg details for PER3):
        Circadian rhythm
    Circadian entrainment
    Herpes simplex infection


    PER3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PER3: 
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PER3 (P566451, 2, 3 ENSP000003550314) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2O960171, 2, 3, ENSP000003720234EBI-2827813,EBI-1180783 MINT-8052850 MINT-8052875 I2D: score=1 STRING: ENSP00000372023
    PER2O150553, ENSP000002546574I2D: score=3 STRING: ENSP00000254657
    CLOCKO155163, ENSP000003087414I2D: score=2 STRING: ENSP00000308741
    CRY1Q165263, ENSP000000085274I2D: score=2 STRING: ENSP00000008527
    CRY2Q49AN03, ENSP000004067514I2D: score=2 STRING: ENSP00000406751
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007165signal transduction ----
    GO:0007623circadian rhythm ----

    PER3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PER3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PER3 gene (5 alternative transcripts): 
    NM_001289861.1  NM_001289862.1  NM_001289863.1  NM_001289864.1  NM_016831.2  

    Unigene Cluster for PER3:

    Period circadian clock 3
    Hs.162200  [show with all ESTs]
    Unigene Representative Sequence: BC146781
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377541(uc001aon.3) ENST00000377532(uc009vmg.1 uc009vmh.1 uc001aoo.3 uc001aop.3 uc010nzw.2)
    ENST00000361923 ENST00000473653 ENST00000602883 ENST00000463106 ENST00000494684

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PER3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PER3 (see all 31):
    hsa-miR-3910 hsa-miR-30c hsa-miR-607 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-1257 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidPER3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PER3
    Predesigned siRNA for gene silencing in human, mouse, rat PER3
    Clone
    Products:
         
    OriGene clones in human, mouse for PER3 (see all 7)
    OriGene ORF clones in mouse, rat for PER3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PER3 (NM_016831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PER3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PER3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PER3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PER3
      QuantiTect SYBR Green Assays in human, mouse, rat PER3
      QuantiFast Probe-based Assays in human, mouse, rat PER3

    Additional mRNA sequence: 

    AB047686.1 AK299123.1 AK307760.1 AK308303.1 AL157954.1 AY493418.1 BC026102.1 BC036937.1 
    BC111010.1 BC144137.1 BC146781.1 

    10 DOTS entries:

    DT.101963691  DT.216372  DT.95274477  DT.97766150  DT.95237249  DT.92064027  DT.121439431  DT.204984 
    DT.95274476  DT.91824222 

    Selected AceView cDNA sequences (see all 169):

    AA194013 BM724400 AI375109 BE886745 BP351218 NM_016831 AI094271 AB047686 
    CB215110 BX477565 BE467015 F09896 Z39320 AL711932 BP343448 BM314558 
    BQ185887 AA490271 AI380787 BQ448083 BF941635 CF243028 BQ184198 AA992403 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PER3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11
    SP1:        -                                                                                                                     
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PER3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PER3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAACGTGA
    PER3 Expression
    About this image


    PER3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    PER3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PER3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162200
        Pathway & Disease-focused RT2 Profiler PCR Array including PER3: 
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PER3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PER3
    QuantiTect SYBR Green Assays in human, mouse, rat PER3
    QuantiFast Probe-based Assays in human, mouse, rat PER3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PER3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PER3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Per31 , 5 period homolog 3 (Drosophila)5
    period circadian clock 31
    72.54(n)1
    64.86(a)1
      4 (81.53 cM)5
    186281  NM_011067.21  NP_035197.21 
     1510036525 
    chicken
    (Gallus gallus)
    Aves PER31 period homolog 3 (Drosophila) 61.55(n)
    54.76(a)
      419366  XM_004947314.1  XP_004947371.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia per31 period circadian clock 3 58.29(n)
    51.69(a)
      780153  NM_001079228.1  NP_001072696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii per32 period homolog 3 (Drosophila) 74.84(n)   58107  NM_131584.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta per6
    period
    9(a)
    1 → many
    X(2579613-2586813)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-426
    Protein LIN-42, isoform c (lin-42) mRNA, complete ...
    15(a)
    1 → many
    II(1233244-1244035) WBGene00018572


    ENSEMBL Gene Tree for PER3 (if available)
    TreeFam Gene Tree for PER3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PER3 gene
    PER12  PER22  
    2 SIMAP similar genes for PER3 using alignment to 5 protein entries:     PER3_HUMAN (see all proteins):
    PER1    PER2

    PER3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PER3
    PGOHUM00000233124


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PER3 (see all 1469)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379495621,2
    Cuntested17887619(+) ATGTCC/TATTCC 2 P L mis11Minor allele frequency- T:0.00NA 4552
    rs586751801,2
    C,F--6991109(+) CCAAGC/TGTCCC 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs1931171451,2
    --6991119(+) CTACCC/GAGATC 1 -- us2k10--------
    rs1996824961,2
    C--6991142(+) ATGCT-/TGC   
       TGAAC
    GAATG
    1 -- us2k10--------
    rs37535021,2
    C,F--6991174(-) TCCGAA/GGCTGG 1 -- us2k12Minor allele frequency- G:0.17NA EA 240
    rs1131264371,2
    C--7008568(+) TTTTTT/-CTTGA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1851808001,2
    --7842766(+) TGGAAC/GATATA 1 -- us2k10--------
    rs1470412721,2
    --7842768(+) GAAGAC/TATAAG 1 -- us2k10--------
    rs1874519231,2
    --7842770(+) AGATAC/TAAGGT 1 -- us2k10--------
    rs2006849951,2
    --7842773(+) TATAA-/GGTGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PER3 (7844380 - 7905237 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PER3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2742917CNV Deletion23290073
    esv2743028CNV Deletion23290073
    esv991458CNV Deletion20482838
    nsv870846CNV Loss21882294
    nsv161033CNV Loss16902084

    Human Gene Mutation Database (HGMD): PER3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PER3
    DNA2.0 Custom Variant and Variant Library Synthesis for PER3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603427    OMIM disorders: --

    Selected diseases for PER3 (see all 29):    
    About MalaCards
    delayed sleep phase syndrome    advanced sleep phase syndrome    seasonal affective disorder    heroin dependence
    sleep disorder    insomnia    bipolar i disorder    schizoaffective disorder
    mood disorder    gestational diabetes    bipolar disorder    chronic myeloid leukemia
    gingivitis    alcohol dependence    dementia    crohn's disease
    inflammatory bowel disease    insulin resistance    herpes simplex    myeloid leukemia


    PER3 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PER3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    advanced sleep phase syndrome 90.1 1 16979429 (1)
    delayed sleep phase syndrome 88.3 4 12841365 (2), 16979429 (1), 17633519 (1)
    breast cancer 0 5 15790588 (2), 15668506 (2)
    cancer 0 1 19926609 (1)

    Genetic Association Database (GAD): PER3
    Human Genome Epidemiology (HuGE) Navigator: PER3 (33 documents)

    Export disorders for PER3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PER3 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with PER3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. (PubMed id 11306557)1, 2, 4 Ebisawa T.... Yamauchi T. (EMBO Rep. 2001)
    2. Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. (PubMed id 18517031)1, 4, 9 Archer S.N....Dijk D.J. (Sleep 2008)
    3. Circadian disruption, Per3, and human cytokine secretion. (PubMed id 19926609)1, 4, 9 Guess J....Hrushesky W.J. (Integr Cancer Ther 2009)
    4. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. (PubMed id 16528748)1, 4, 9 Nievergelt C.M....Kelsoe J.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    5. A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. (PubMed id 18789374)1, 4, 9 Benedetti F....Smeraldi E. (Neurosci. Lett. 2008)
    6. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PubMed id 19934327)1, 4, 9 Zhu Y....Stanford J.L. (Cancer Res. 2009)
    7. Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? (PubMed id 15700718)1, 4, 9 Pereira D.S....Pedrazzoli M. (Sleep 2005)
    8. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4, 9 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
    9. Association between specific diurnal preference questionnaire items and PER3 VNTR genotype. (PubMed id 19360490)1, 4, 9 Ellis J....Archer S.N. (Chronobiol. Int. 2009)
    10. The association of CLOCK gene T3111C polymorphism and hPER3 gene 54-nucleotide repeat polymorphism with Chinese Han people schizophrenics. (PubMed id 20364331)1, 4 Zhang J....Wang Z. (Mol. Biol. Rep. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8863 HGNC: 8847 AceView: PER3 Ensembl:ENSG00000049246 euGenes: HUgn8863
    ECgene: PER3 Kegg: 8863 H-InvDB: PER3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PER3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PER3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PER3 gene:
    Search GeneIP for patents involving PER3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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