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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PER3 Gene

protein-coding   GIFtS: 57
GCID: GC01P007778

period circadian clock 3

(Previous names: period (Drosophila) homolog 3, period homolog 3 (Drosophila)...)
 Explore 25 diseases affiliated with
PER3 via our new
 Human Malady Compendium 
Biological research products
for PER3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Period Circadian Clock 31 2     GIG132
Cell Growth-Inhibiting Gene 13 Protein2 3     Growth-Inhibiting Protein 132
Circadian Clock Protein PERIOD 32 3     Period 32
HPER31     Period Circadian Protein 32
Period (Drosophila) Homolog 31     Period Circadian Protein Homolog 32
Period Homolog 3 (Drosophila)1     Period Homolog 32

External Ids:    HGNC: 88471   Entrez Gene: 88632   Ensembl: ENSG000000492467   OMIM: 6034275   UniProtKB: P566453   

Export aliases for PER3 gene to outside databases

Previous GC identifers: GC01P007426 GC01P007653 GC01P007554 GC01P006993


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PER3:
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic
nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the
circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus
continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in
the suprachiasmatic nucleus. The specific function of this gene is not yet known. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PER3_HUMAN, P56645
Function: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme

Gene Wiki entry for PER3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PER3 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   CUTL1   POU3F2   NF-kappaB   Roaz   FOXL1   NF-kappaB2   MRF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPER3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PER3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.23

PER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PER3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P007778:  view genomic region     (about GC identifiers)

Start:
7,844,380 bp from pter      End:
7,905,237 bp from pter
Size:
60,858 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PER3_HUMAN, P56645 (See protein sequence)
Recommended Name: Period circadian protein homolog 3  
Size: 1201 amino acids; 131888 Da
Subunit: Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1
or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1, CRY2, and
TIMELESS. Interaction with CSNK1D or CSKN1E promotes nuclear location of PER proteins (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Translocates to the
nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS (By similarity)
Sequence caution: Sequence=BAB32925.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5H8X4 Q5H8X5 Q969K6 Q96S77 Q96S78 Q9C0J3 Q9NSP9 Q9UGU8
Alternative splicing: 2 isoforms:  P56645-1   P56645-2   

Explore the universe of human proteins at neXtProt for PER3: NX_P56645

Post-translational modifications:

  • Phosphorylation appears to require association with PER1 and translocation to the nucleus (By similarity)1
  • Ubiquitinated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56645

  • PER3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_058515.1  
    ENSEMBL proteins: 
     ENSP00000366764   ENSP00000366755   ENSP00000355031  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: PER3
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    Novus Biologicals PER3 Proteins
    Novus Biologicals PER3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PER3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    PER3 for ontologies           About GeneDecksing



    PER3 Antibody Products: 
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    Search ThermoFisher Antibodies for PER3

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    Uscn ELISAs and CLIAs for PER3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PER3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013655 PAS_fold_3
     IPR001610 PAC
     IPR000014 PAS
     IPR022728 Period_circadian-like_C

    Graphical View of Domain Structure for InterPro Entry P56645

    ProtoNet protein and cluster: P56645

    1 Blocks protein family: IPB001610 PAC motif

    UniProtKB/Swiss-Prot: PER3_HUMAN, P56645
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PER3_HUMAN, P56645
    Function: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PER3
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate PER3 (see all 31):
    hsa-miR-3910 hsa-miR-30c hsa-miR-607 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-1257 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidPER3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PER3 (see all 7)
    OriGene shRNA RFP: PER3
    OriGene siRNA: PER3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PER3

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    GenScript: all cDNA clones in your preferred vector: PER3 (NM_016831)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PER3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PER3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding ----


    PER3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Per3tm1Drw for PER3
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Per3):
     behavior/neurological  nervous system  vision/eye 

    PER3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Circadian rhythm - mammal
    Circadian rhythm - mammal1.00
    Circadian Clock in Mammals0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PER3
        Circadian Clock in Mammals


    1         Kegg Pathway  (Kegg details for PER3):
        Circadian rhythm - mammal


    PER3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for PER3 (P566452, 3 ENSP000003550314) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2O960172, 3, ENSP000003720234MINT-8052850 MINT-8052875 I2D: score=1 STRING: ENSP00000372023
    PER2O150553, ENSP000002546574I2D: score=3 STRING: ENSP00000254657
    CLOCKO155163, ENSP000003087414I2D: score=2 STRING: ENSP00000308741
    CRY1Q165263, ENSP000000085274I2D: score=2 STRING: ENSP00000008527
    CRY2Q49AN03, ENSP000004067514I2D: score=2 STRING: ENSP00000406751
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007623circadian rhythm IEA--


    PER3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PER3
    Search CenterWatch for drugs/clinical trials and news about PER3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PER3 gene: 
    NM_016831.1  

    Unigene Cluster for PER3:

    Period circadian clock 3
    Hs.162200  [show with all ESTs]
    Unigene Representative Sequence: BC146781
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377541(uc001aon.3) ENST00000377532(uc009vmg.1 uc009vmh.1 uc001aoo.3 uc001aop.3 uc010nzw.2)
    ENST00000361923 ENST00000473653 ENST00000463106 ENST00000494684

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PER3
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate PER3 (see all 31):
    hsa-miR-3910 hsa-miR-30c hsa-miR-607 hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-1257 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidPER3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PER3 (see all 7)
    OriGene shRNA RFP: PER3
    OriGene siRNA: PER3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PER3
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PER3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PER3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PER3

    Additional cDNA sequence: 

    AB047686.1 AK299123.1 AK307760.1 AK308303.1 AL157954.1 AY493418.1 BC026102.1 BC036937.1 
    BC111010.1 BC144137.1 BC146781.1 

    11 DOTS entries:

    DT.101963691  DT.216372  DT.95274477  DT.97766150  DT.95237249  DT.92064027  DT.100778763  DT.121439431 
    DT.204984  DT.95274476  DT.91824222 

    24/169 AceView cDNA sequences (see all 169):

    BU741665 AA364758 BM547324 BM724400 CF243028 CN480408 BQ185887 AI380787 
    AA481037 NM_016831 AL711932 AL157954 AI094271 AI638270 BF941635 BU165415 
    CB215110 Z39320 AA194013 AI375109 AA233745 BE467015 BM314558 BP351218 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PER3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11
    SP1:        -                                                                                                                     
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PER3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PER3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAAACGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PER3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PER3

    SOURCE GeneReport for Unigene cluster: Hs.162200
        SABiosciences Expression via Pathway-Focused PCR Array including PER3: 
              Circadian Rhythms in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PER3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PER3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Per31 , 5 period homolog 3 (Drosophila)1, 5 70.4(n)1
    63.33(a)1
      4 (81.53 cM)5
    186281  NM_011067.21  NP_035197.21 
     1510036525 
    chicken
    (Gallus gallus)
    Aves PER31 period homolog 3 (Drosophila) 59.08(n)
    51.83(a)
      419366  XM_417528.3  XP_417528.3 
    zebrafish
    (Danio rerio)
    Actinopterygii per32 period homolog 3 (Drosophila) 74.84(n)   58107  NM_131584.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta per6
    period
    12(a)
    1 → many
    X(2579613-2586813)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-426
    abnormal cell LINeage family member (lin-42)
    17(a)
    1 → many
    II(1233957-1244042)


    ENSEMBL Gene Tree for PER3 (if available)
    TreeFam Gene Tree for PER3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PER3 gene
    PER12  PER22  
    2 SIMAP similar genes for PER3 using alignment to 5 protein entries:     PER3_HUMAN (see all proteins):
    PER1    PER2

    PER3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PER3
    PGOHUM00000233124


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1220 NCBI SNPs in PER3 are shown (see all 1220    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851808001,2
    --7842766(+) TGGAAC/GATATA 1 -- us2k10--------
    rs1470412721,2
    --7842768(+) GAAGAC/TATAAG 1 -- us2k10--------
    rs1874519231,2
    --7842770(+) AGATAC/TAAGGT 1 -- us2k10--------
    rs2006849951,2
    --7842773(+) TATAA-/GGTGGT 1 -- us2k10--------
    rs1923114021,2
    --7842821(+) CCCCTC/TTTCCT 1 -- us2k10--------
    rs784959811,2
    F,--7842955(+) CAGACA/TTTTTT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1841520441,2
    --7842980(+) CAACTC/TCTTTT 1 -- us2k10--------
    rs780181771,2
    F,--7843007(+) TTTACG/CTTTGT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1155561901,2
    F,--7843112(+) GCTCAC/GGCCAG 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs580735881,2
    C,--7843197(+) CAGACC/TATCTT 1 -- us2k12Minor allele frequency- T:0.08WA 120

    HapMap Linkage Disequilibrium report for PER3 (7844380 - 7905237 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PER3
         1 CNV: 5464
    Human Gene Mutation Database (HGMD): PER3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PER3
    DNA2.0 Custom Variant and Variant Library Synthesis for PER3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PER3 for disorders           About GeneDecksing

    OMIM gene information: 603427    OMIM disorders: --

    20/25 diseases for PER3 (see all 25):    About MalaCards
    advanced sleep phase syndrome    delayed sleep phase syndrome    seasonal affective disorder    heroin dependence
    bipolar i disorder    schizoaffective disorder    chronic myeloid leukemia    epithelial ovarian cancer
    mood disorder    sleep disorder    myeloid leukemia    insulin resistance
    bipolar disorder    ovarian cancer    crohn's disease    breast cancer
    hepatocellular carcinoma    gingivitis    dementia    leukemia

    4 Novoseek disease relationships for PER3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    advanced sleep phase syndrome 90.1 1 16979429 (1)
    delayed sleep phase syndrome 88.3 4 12841365 (2), 16979429 (1), 17633519 (1)
    breast cancer 0 5 15790588 (2), 15668506 (2)
    cancer 0 1 19926609 (1)

    Genetic Association Database (GAD): PER3
    Human Genome Epidemiology (HuGE) Navigator: PER3 (33 documents)

    Export disorders for PER3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PER3 gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with PER3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. (PubMed id 11306557)1, 2, 4 Ebisawa T.... Yamauchi T. (2001)
    2. Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? (PubMed id 15700718)1, 4, 9 Pereira D.S....Pedrazzoli M. (2005)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Pharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-up. (PubMed id 15475734)1, 4 Serretti A....Smeraldi E. (2004)
    5. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. (PubMed id 12655319)1, 2 Johansson C.... Partonen T. (2003)
    6. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. (PubMed id 9427249)1, 3 Shearman L.P....Reppert S.M. (1997)
    7. Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. (PubMed id 18517031)1, 9 Archer S.N....Dijk D.J. (2008)
    8. Downregulation of circadian clock genes in chronic myeloid leukemia: alternative methylation pattern of hPER3. (PubMed id 16999817)1, 9 Yang M.Y....Lin S.F. (2006)
    9. Transcriptional activation of the neuronal peripherin-encoding gene depends on a G + C-rich element that binds Sp1 in vitro and in vivo. (PubMed id 7622044)1, 9 Ferrari N....Royal A. (1995)
    10. Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects. (PubMed id 19013183)1, 9 Hida A....Mishima K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8863 HGNC: 8847 AceView: PER3 Ensembl:ENSG00000049246 euGenes: HUgn8863
    ECgene: PER3 Kegg: 8863 H-InvDB: PER3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PER3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PER3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PER3 gene:
    Search GeneIP for patents involving PER3

    GeneCards and IP:
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