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PEPD Gene

protein-coding   GIFtS: 62
GCID: GC19M033877

Peptidase D

  See PEPD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidase D1 2 3     imidodipeptidase2
Proline Dipeptidase2 3     Xaa-Pro Dipeptidase2
X-Pro Dipeptidase2 3     EC 3.4.13.93
prolidase1     Imidodipeptidase3
PROLIDASE2     PRD3
Aminoacyl-L-Proline Hydrolase2     Prolidase3

External Ids:    HGNC: 88401   Entrez Gene: 51842   Ensembl: ENSG000001242997   OMIM: 6132305   UniProtKB: P129553   

Export aliases for PEPD gene to outside databases

Previous GC identifers: GC19M034495 GC19M034326 GC19M038553 GC19M038569 GC19M030378


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PEPD Gene:
This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or
tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the
recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in
prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing
proline. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by
RefSeq, Oct 2009)

GeneCards Summary for PEPD Gene:
PEPD (peptidase D) is a protein-coding gene. Diseases associated with PEPD include prolidase deficiency, and bacterial vaginosis. GO annotations related to this gene include metallocarboxypeptidase activity and manganese ion binding.

UniProtKB/Swiss-Prot: PEPD_HUMAN, P12955
Function: Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important
role in collagen metabolism because the high level of iminoacids in collagen

Gene Wiki entry for PEPD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PEPD gene promoter:
         PPAR-gamma1   IRF-7A   RelA   Nkx2-5   PPAR-gamma2   HNF-3beta   NF-kappaB   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PEPD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PEPD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

PEPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEPD gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M033877:  view genomic region     (about GC identifiers)

Start:
33,877,855 bp from pter      End:
34,012,799 bp from pter
Size:
134,945 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PEPD_HUMAN, P12955 (See protein sequence)
Recommended Name: Xaa-Pro dipeptidase  
Size: 493 amino acids; 54548 Da
Cofactor: Binds 2 manganese ions per subunit
Subunit: Homodimer
Mass spectrometry: Mass=54251.73; Method=MALDI; Range=2-493; Source=PubMed:11840567;
2 PDB 3D structures from and Proteopedia for PEPD:
2IW2 (3D)        2OKN (3D)    
Secondary accessions: A8K3Z1 A8K416 A8K696 A8MX47 B4DDB7 B4DGJ1 E9PCE8 Q8TBN9 Q9BT75
Alternative splicing: 3 isoforms:  P12955-1   P12955-2   P12955-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PEPD: NX_P12955

Explore proteomics data for PEPD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PEPD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000276.2  NP_001159528.1  NP_001159529.1  

    ENSEMBL proteins: 
     ENSP00000244137   ENSP00000380226   ENSP00000391890   ENSP00000468516   ENSP00000476514  
     ENSP00000476667   ENSP00000476869  

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    Cloud-Clone Corp. Proteins for PEPD

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR007865 Aminopep_P_N
     IPR000994 Pept_M24_structural-domain
     IPR001131 Peptidase_M24B_aminopep-P_CS

    Graphical View of Domain Structure for InterPro Entry P12955

    ProtoNet protein and cluster: P12955

    1 Blocks protein domain: IPB007865 Aminopeptidase P

    UniProtKB/Swiss-Prot: PEPD_HUMAN, P12955
    Similarity: Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily


    Find genes that share domains with PEPD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PEPD_HUMAN, P12955
    Function: Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important
    role in collagen metabolism because the high level of iminoacids in collagen
    Catalytic activity: Hydrolysis of Xaa- -Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action
    on Pro- -Pro

         Genatlas biochemistry entry for PEPD:
    peptidase D

         Enzyme Number (IUBMB): EC 3.4.13.91

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0004181metallocarboxypeptidase activity TAS1972707
    GO:0008233peptidase activity ----
    GO:0016805dipeptidase activity IEA--
    GO:0030145manganese ion binding IEA--
         
    Find genes that share ontologies with PEPD           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PEPD:
     Decreased influenza A/WSN/33 r  Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target PEPD:
    hsa-mir-423-3p (MIRT042567)

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    SwitchGear 3'UTR luciferase reporter plasmidPEPD 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PEPD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PEPD
    Interactions:

        GeneGlobe Interaction Network for PEPD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PEPD (P129552, 3 ENSP000002441374) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628053, ENSP000003665814I2D: score=4 STRING: ENSP00000366581
    HIST1H4CP628053, ENSP000003670344I2D: score=4 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=4 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=4 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=4 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS1972707
    GO:0006520cellular amino acid metabolic process TAS1972707
    GO:0030574collagen catabolic process IEA--

    Find genes that share ontologies with PEPD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PEPD

    2 HMDB Compounds for PEPD    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glycylproline1-(Aminoacetyl)proline (see all 6)704-15-416642978
    Manganesemanganese 7439-96-5--

    Selected Novoseek inferred chemical compound relationships for PEPD gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycylproline 93.2 14 15530480 (2), 9972056 (1), 10582130 (1), 1536787 (1) (see all 7)
    proline 85.7 151 15696600 (5), 11820612 (4), 1437403 (3), 9581474 (3) (see all 70)
    acetylproline 85.4 2 2246246 (1), 1545347 (1)
    pepq 81.2 3 12859771 (1), 8633861 (1), 10075426 (1)
    anthraquinone-2-carboxylic acid 79.7 3 9972056 (3)
    hydroxyproline 76.4 33 8031960 (2), 9112701 (1), 17999410 (1), 18806117 (1) (see all 24)
    melphalan 52.8 31 14572862 (4), 10697434 (3), 17377743 (3), 15804176 (3) (see all 8)
    chlorambucil 50.1 9 9581474 (3), 11338665 (3), 15178351 (1)
    tripeptide s 48.1 1 9879669 (1)
    6-phosphogluconate 36.7 1 7810807 (1)



    Find genes that share compounds with PEPD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PEPD gene (3 alternative transcripts): 
    NM_000285.3  NM_001166056.1  NM_001166057.1  

    Unigene Cluster for PEPD:

    Peptidase D
    Hs.36473  [show with all ESTs]
    Unigene Representative Sequence: NM_000285
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593085 ENST00000244137(uc002nur.4) ENST00000589598 ENST00000591968
    ENST00000397032(uc010xrr.2) ENST00000436370(uc002nuq.4 uc010xrs.2)
    ENST00000588328 ENST00000590731 ENST00000609145 ENST00000593163 ENST00000588719
    ENST00000590755 ENST00000590408
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): PEPD (NM_000285)
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      QuantiFast Probe-based Assays in human, mouse, rat PEPD

    Additional mRNA sequence: 

    AK057538.1 AK225037.1 AK290756.1 AK290781.1 AK291561.1 AK293126.1 AK294619.1 BC004305.1 
    BC015027.1 BC028295.1 BT006692.1 CR541669.1 J04605.1 

    19 DOTS entries:

    DT.447692  DT.100793949  DT.100793951  DT.121501050  DT.91772559  DT.100732650  DT.100793956  DT.121501026 
    DT.100793952  DT.40315802  DT.100793964  DT.100804841  DT.100810995  DT.120978751  DT.121500975  DT.121500988 
    DT.121500996  DT.100810001  DT.95256615 

    Selected AceView cDNA sequences (see all 455):

    CR626494 BI756568 BM756066 BQ006951 BF432095 CB216666 BG767493 BM755925 
    BQ720584 CA445150 AA906251 BG770634 BE396008 CA397698 BQ021219 CA429295 
    CF272305 BF476206 N33079 BM023632 AW271523 BX113786 BM920899 CF264855 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PEPD (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:              -                                                                       -           -                     
    SP2:              -                                                                                                         
    SP3:              -     -     -     -                       -     -                                                         
    SP4:                                                                                                  -                     
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for PEPD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PEPD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGCTGTG
    PEPD Expression
    About this image


    PEPD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
     
     Adipose (Muscoskeletal System)
    PEPD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PEPD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.36473
        Custom PCR Arrays for PEPD
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PEPD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEPD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PEPD gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pepd1 , 5 peptidase D1, 5 84.18(n)1
    89.05(a)1
      7 (20.70 cM)5
    186241  NM_008820.21  NP_032846.21 
     349123795 
    chicken
    (Gallus gallus)
    Aves PEPD1 peptidase D 74.78(n)
    79.11(a)
      415776  NM_001079717.1  NP_001073185.1 
    lizard
    (Anolis carolinensis)
    Reptilia PEPD6
    peptidase D
    69(a)
    1 ↔ 1
    GL343508.1(517939-630186)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054994.12   -- 74.32(n)    BC054994.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055252.12   -- 75.46(n)   337498  BC055252.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dip-C1 , 3 dipeptidyl-peptidase3
    Dipeptidase C1
    50(a)3
    59.83(n)1
    53.35(a)1
      87B93
    477691  NM_141935.31  NP_650192.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K12C11.11 , 3 K12C11.11 52(a)3
    56.62(n)1
    54.78(a)1
      I(1341234-1342265)3
    1717041  NM_058442.31  NP_490843.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YFR006W)4 Putative X-Pro aminopeptidase; green fluorescent protein more   --   6(156145-157752) 850556  NP_116661.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G294901 AT4G29490 56.88(n)
    58.75(a)
      829070  NM_119094.4  NP_194678.2 
    rice
    (Oryza sativa)
    Liliopsida Os.275342 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.33(n)    AK064268.1 


    ENSEMBL Gene Tree for PEPD (if available)
    TreeFam Gene Tree for PEPD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PEPD gene

    Find genes that share paralogs with PEPD           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PEPD
    PGOHUM00000237113


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PEPD (see all 3143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0116154
    Prolidase deficiency (PD)4--see VAR_0116152 G D mis40--------
    VAR_0044044
    Prolidase deficiency (PD)4--see VAR_0044042 D N mis40--------
    VAR_0116144
    Prolidase deficiency (PD)4--see VAR_0116142 R Q mis40--------
    VAR_0044054
    Prolidase deficiency (PD)4--see VAR_0044052 G R mis40--------
    rs1219177251,2
    Cpathogenic134060009(-) ACGACC/TGAACG 6 R * stg10--------
    rs1408421,2
    C--33877912(+) GACAG-/AAAGT 
            
    AAAGT
    3 -- ut310--------
    rs106596041,2
    C--33877913(+) AAGTA-/AAAG  
     T
    /AAGTA
    TCAGA
    6 -- ut310--------
    rs794865191,2
    C--33878074(+) ATTAA-/TTAA  
            
    AAAAG
    3 -- ut310--------
    rs1113760441,2
    C--33880403(+) GGGCTC/-TCCCC 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs785214731,2
    C,F--33881647(+) GCCAAC/GGGGCC 3 -- int17Minor allele frequency- G:0.22WA NA CSA EA 365
    rs802418211,2
    C,F--33881650(+) AACGGG/TCCCCA 3 -- int17Minor allele frequency- T:0.22WA NA CSA EA 365
    rs2001250981,2
    --33881650(+) ACGGG-/TCCCCA 3 -- int10--------
    rs1136895501,2
    C--33883059(+) GGGAGC/-CCAGA 3 -- int12Minor allele frequency- -:0.25CSA 4
    rs58278481,2
    C--33883822(+) CCTTT-/AAGTGC 3 -- int12Minor allele frequency- A:0.25CSA 4
    rs799952141,2
    --33883822(+) CCTTTA/TAGTGC 3 -- int10--------
    rs105617331,2
    C--33884460(+) CTGGTCAAA/-  
            
    CAAAC
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs680351211,2
    C--33884462(+) AAACAAACA/-  
            
    GCCAC
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs579610621,2
    C--33895364(+) TAAAA-/AACAACAA 3 -- int10--------
    rs345906081,2
    C--33895724(+) AAAAAA/-TCCCC 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs582992651,2
    C--33906482(+) CTCTC-/TCGCCTG 3 -- int10--------
    rs58278501,2
    C--33911113(+) TCCCC-/AAAGCC 3 -- int10--------
    rs58278521,2
    C--33911116(+) CCAAG-/A/A   
      G
    /C/GC
    CCTGG
    3 -- int10--------
    rs347485221,2
    C--33911264(+) AGGCAT/-TTTTT 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs1464525971,2
    C--33913330(+) CTATC-/CTA   
      T
    /TATC
    ATCTA
    3 -- int10--------
    rs1447329751,2
    C--33913534(+) ATCTA-/ATC   
      T
    /TCTA
    CCTAC
    3 -- int10--------
    rs567342001,2
    C--33914001(+) CCATC-/CATC/CATCCAT
    C
    /CATCCATCCATC
    TATCC
    6 -- int1 cds10--------
    rs586481181,2
    C--33916206(+) ACAAA-/CAAA  
            
    AAGGC
    3 -- int10--------
    rs614381351,2
    C--33918160(+) ATCTC-/GTGGCTC
    ATGGCATCTC
    TAGCA
    3 -- int10--------
    rs352378231,2
    C--33919447(+) TCCAC-/CTCCTG 3 -- int11Minor allele frequency- C:0.00CSA 2
    rs107178011,2
    C--33924904(+) GAAGA-/CCCCAG 3 -- int11Minor allele frequency- C:0.00NA 2
    rs796821271,2
    C--33924904(+) GAAGAA/CCCCAG 3 -- int10--------
    rs783762771,2
    C--33933313(+) GTCTC-/A/AA  
            
    AAAAA
    3 -- int10--------
    rs58278541,2
    C--33935795(+) GGACA-/ACATTTTA 3 -- int10--------
    rs720430661,2
    C--33958063(+) AAAAA-/AAGAAAG 3 -- int10--------
    rs343833041,2
    C--33958155(+) GCTTGG/-TGACA 3 -- int11Minor allele frequency- -:0.50NA 2
    rs352736501,2
    C--33968815(+) AGAAA-/AGGCTA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs3679186831,2
    C--33975667(+) GATAG-/ACACACA 3 -- int10--------
    rs753127341,2
    C,F--33982768(+) TTAAAT/CTGTGG 3 -- int12Minor allele frequency- C:0.02WA NA 122
    rs1872752161,2
    --33989696(+) TGGAGA/GCAGGT 3 -- int10--------
    rs1432737411,2
    --33989715(+) CGCCAC/GAGTCC 3 -- int10--------
    rs1908806781,2
    --33989731(+) ACAGGA/GTCCTG 3 -- int10--------
    rs1822083591,2
    --33989744(+) GTCAGA/GTGCCC 3 -- int10--------
    rs1475203621,2
    --33989750(+) TGCCCG/TTTCCA 3 -- int10--------
    rs1854493321,2
    --33989807(+) AGGGTC/TCTTGA 3 -- int10--------
    rs351814141,2
    C--34001267(+) AGGGGGG/-CTCCA 3 -- int11Minor allele frequency- -:0.50NA 2
    rs730411471,2
    C,F--34001331(+) TATGCA/CGAGGC 3 -- int11Minor allele frequency- C:0.05NA 120
    rs1824314611,2
    --34034788(+) GCAGCA/GTTGCT 3 -- ds50010--------
    rs1475103561,2
    --34034812(+) ACCTCA/GGGCTG 3 -- ds50010--------
    rs81004081,2
    C,F--34034923(+) GCCATT/CGCCCC 3 -- ds50015Minor allele frequency- C:0.15NA CSA WA EA 362
    rs81110271,2
    C,F,A--34034933(+) CTAGAC/GGTTGG 3 -- ds50018Minor allele frequency- G:0.23NA WA CSA EA 367
    rs1176081391,2
    F--34035051(+) GCCCCG/AAGTCC 3 -- ds50011Minor allele frequency- A:0.03EA 120
    rs81112941,2
    C,F,A,H--34035159(+) ACCATT/CTTCCT 3 -- ds500133Minor allele frequency- C:0.48NA EA NS WA CSA 3133
    rs1858230371,2
    --34035282(+) GAAACC/GTTTTA 3 -- ut310--------
    rs1400387831,2
    --34035411(+) AGCATC/TATTTT 3 -- ut310--------
    rs347421621,2
    F--34035433(+) AGTCGG/CTCATT 3 -- ut311Minor allele frequency- C:0.50NA 4
    rs35561,2
    C,F,A,H--34035454(-) TGTTTT/CATACC 3 -- ut31 ese325Minor allele frequency- C:0.34MN NS EA NA WA CSA 2722
    rs164261,2
    C,F--34035486(+) AAGGG-/TAAT  
            
    TAATT
    3 -- ut314Minor allele frequency- TAAT:0.21EU NA EA 342
    rs1499148451,2
    C--34035538(+) GATCAA/GATGCC 3 -- ut310--------
    rs776904631,2
    C,F--34035612(+) ATCACG/AAAAAG 3 -- ut311Minor allele frequency- A:0.08EA 120
    rs10613381,2
    C,F,A,H--34035613(-) TCTTTT/CCGTGA 3 -- ut3126Minor allele frequency- C:0.29MN NS EA NA CSA WA EU 3591
    rs2005670731,2
    C--34035684(+) AGAAGC/GGGGTA 6 P R mis10--------
    rs1449444401,2
    C--34035705(+) CACAGA/CCTGCC 6 G V mis10--------
    rs2000721431,2
    C--34035733(+) TTCCAC/TAGTGC 6 M V mis10--------
    rs2012229331,2
    C--34035762(+) GCTCTA/GTGCCG 6 T I mis10--------
    rs1999993331,2
    C--34035773(+) CTGTCA/CGTCAC 6 T syn10--------
    rs1895495811,2
    --34035781(+) CACCAC/TGACGT 6 M V mis10--------
    rs2019157651,2
    --34035828(+) CACATC/TATCAT 3 -- int10--------
    rs1809903501,2
    --34035878(+) TCCAGA/GCCCAC 3 -- int10--------
    rs23031011,2
    C,F,H--34036074(+) TGACAG/CACCAC 3 -- int15Minor allele frequency- C:0.02EA NS 1916
    rs771635811,2
    C,F--34036081(+) CCACAC/TGAAGG 3 -- int12Minor allele frequency- T:0.02WA NA 238
    rs1904172551,2
    C--34036147(+) AAGGAA/GTCTGC 3 -- int10--------
    rs1154347321,2
    C,F--34036164(+) AGTGGA/TGGTGG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1142755131,2
    C,F--34036167(+) GGAGGT/CGGCAG 3 -- int11Minor allele frequency- C:0.01WA 118
    rs2009246471,2
    --34036196(+) TGGGGC/TCCGTG 3 -- int10--------
    rs22300631,2
    H--34036226(-) CGCTTT/CCGCGG 6 /F syn15Minor allele frequency- C:0.00MN NS EA 466
    rs175701,2,,4
    C,F--34036252(-) CCTTCC/TTTAAC 6 L F mis118Minor allele frequency- T:0.27MN NA NS EA WA CSA 1151
    rs1490424271,2
    C--34036261(+) GGAGGC/TGCGGG 6 T A mis10--------
    rs1830380271,2
    --34036274(+) GGGTCC/TGCCAG 6 A syn10--------
    rs1420704981,2
    C--34036299(+) GGTGGC/TCGATG 6 D G mis10--------
    rs22300621,2,,4
    C,F--34036392(-) GGAGCG/ACATCG 6 /H /R mis1 ese35Minor allele frequency- A:0.08EA NA 1762
    rs1466573991,2
    --34036537(+) AGACTC/TGCCCC 3 -- int10--------
    rs1155533101,2
    F--34036564(+) GGGCAC/TCCTGA 3 -- int11Minor allele frequency- T:0.06WA 118
    rs2012186451,2
    --34036619(+) TGGCC-/ACACTACC 3 -- int10--------
    rs1996200761,2
    --34036625(+) CACTA-/CCCTAG 3 -- int10--------
    rs1385295121,2
    C--34036632(+) CTAGG-/GCTT  
            
    GCTTG
    3 -- int10--------
    rs1455172341,2
    --34036710(+) TGGCTA/GAGGGT 3 -- int10--------
    rs1861182441,2
    --34036852(+) AGAAAC/TTGGCC 3 -- int10--------
    rs770758751,2
    C,F--34036867(+) AAGTCG/ATGGTC 3 -- int11Minor allele frequency- A:0.04EA 120
    rs1918364711,2
    --34036895(+) AGGCCC/GAGATT 3 -- int10--------
    rs8891361,2
    C,F,H--34036898(+) CCCAGG/ATTTTC 3 -- int119Minor allele frequency- A:0.01NA NS EA WA CSA 811
    rs1166019451,2
    C,F--34036946(+) GGTGGG/ATCTGC 3 -- int11Minor allele frequency- A:0.09WA 118
    rs722684591,2
    C--34037174(+) GCACA-/GCTGAGGGG
    GCCTCAGCTTG
    GCTGA
    3 -- int10--------
    rs1380716691,2
    --34037360(+) AGGAAC/GCCCAG 3 -- int10--------
    rs37868931,2
    C,F,H--34037415(+) AACATC/GAGACT 3 -- int127Minor allele frequency- N:0.00EA NA NS WA CSA 3183
    rs1841233051,2
    --34037436(+) GTTCAC/TGTAAG 3 -- int10--------
    rs760716791,2
    F--34037521(+) AGGGAC/TAGCCA 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1888815271,2
    --34037763(+) GGTCCC/TAGGGT 3 -- int10--------
    rs126109251,2
    C,F,A,H--34037764(+) GTCCCA/GGGGTC 3 -- int17Minor allele frequency- G:0.42WA NA CSA EA 367
    rs1500866051,2
    C--34037782(+) CAGGA-/CCTTCC 3 -- int10--------
    rs613484541,2
    C,F--34037969(+) CCATCC/TCCATG 3 -- int13Minor allele frequency- T:0.07WA CSA 122
    rs1926620681,2
    C--34037985(+) ACCCCA/GGCTGC 3 -- int10--------
    rs1150690671,2
    C,F--34038001(+) GGTACA/GCGGTT 3 -- int11Minor allele frequency- G:0.01WA 118
    rs1823345791,2
    --34038035(+) AGAAAC/TGAACT 3 -- int10--------
    rs1156816071,2
    C,F--34038195(+) CCTGCT/CGAGAA 3 -- int11Minor allele frequency- C:0.01WA 118
    rs730301201,2
    C,F--34038200(+) TGAGAA/GCAGGG 3 -- int11Minor allele frequency- G:0.21NA 120
    rs1408290911,2
    C--34038213(+) CAGGCA/GCCATA 3 -- int10--------
    rs118804291,2
    C,F,H--34038240(+) TGGGCC/TGGGTG 3 -- int12Minor allele frequency- T:0.10NA WA 122
    rs1504363781,2
    C--34038241(+) GGGCCA/GGGTGG 3 -- int10--------
    rs1150290331,2
    C,F--34038295(+) GAAGCG/ACAGCC 3 -- int11Minor allele frequency- A:0.03WA 118
    rs37868941,2
    C,F,H--34038338(+) CGCCCA/TTGCTC 3 -- int17Minor allele frequency- T:0.21EA NS NA 2130
    rs1870059141,2
    --34038497(+) GAATAA/GACTCT 3 -- int10--------
    rs797290611,2
    C,F--34038544(+) AGTTTG/TCTGCC 3 -- int11Minor allele frequency- T:0.07NA 120
    rs1444706251,2
    C--34038564(+) GGTGG-/AAAAAA 3 -- int10--------
    rs1916947171,2
    --34038581(+) TTTGGC/TGACTA 3 -- int10--------
    rs112861131,2
    C--34038934(+) CCCAGC/-CGCCC 3 -- int11Minor allele frequency- -:0.00NA 2
    rs776205901,2
    C,F--34038994(+) TTACCC/TTCTGG 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1842016771,2
    --34039038(+) AGATGA/GCCCCC 3 -- int10--------
    rs1144936021,2
    C,F--34039047(+) CCAGCC/GTCCCT 3 -- int11Minor allele frequency- G:0.03WA 118
    rs1874352371,2
    --34039221(+) TCCCCA/CCGCCC 3 -- int10--------
    rs1930481091,2
    --34039222(+) CCCCAC/TGCCCC 3 -- int10--------
    rs169680671,2
    C,F--34039273(+) CCACGC/TAGCTC 3 -- int111Minor allele frequency- N:0.00NA EA WA CSA 579
    rs775506561,2
    C,F--34039380(+) CAGCAG/TGCAGA 3 -- int16Minor allele frequency- T:0.20WA CSA NA EA 363
    rs1423830861,2
    --34039385(+) GCAGA-/CCAGCA 3 -- int10--------
    rs1382042101,2
    --34039441(+) GTCTTA/GGCCAG 3 -- int10--------
    rs1480128231,2
    --34039596(+) CTCCG-/CCC   
      CCCCCC
    CCTGC
    3 -- cds10--------
    rs1856052761,2
    C--34039596(+) ACTCCA/GCCTGC 3 -- int10--------
    rs2004464801,2
    --34039600(+) CGCCTA/GCCATG 3 -- int10--------
    rs175691,2
    C,F,H--34039638(-) GTGCAC/G/TGACGT 9 H Q mis1 syn1 ese322MN EA NA NS CSA EU 3800
    rs1495794511,2
    C--34039671(+) AGCCCA/GTGAGG 6 H syn10--------
    rs2001830311,2
    C--34039675(+) CGTGAA/GGCATA 6 P L mis10--------
    rs2019757961,2
    C--34039686(+) AACACA/GGCCCC 6 A syn10--------
    rs2010892531,2
    C--34039690(+) CGGCCC/TCCAGG 6 E G mis10--------
    rs169680701,2
    C,F--34039874(+) GGAGAT/CGTGAA 3 -- int110Minor allele frequency- C:0.20NA WA CSA EA 500
    rs1115558491,2
    C,F--34039975(+) GTGGCC/TCCCCG 3 -- int12Minor allele frequency- T:0.02CSA WA 120
    rs1905310261,2
    --34039990(+) GGGCTA/TTCCCA 3 -- int10--------
    rs175309761,2
    C,F--34040014(+) CCCTCG/AGGACC 3 -- int14Minor allele frequency- A:0.01NA 256
    rs758247771,2
    C,F--34040042(+) CTGCCT/CCTAGG 3 -- int17Minor allele frequency- C:0.21WA NA CSA EA 365
    rs22413821,2
    C,F,H--34040068(+) CCTGTA/GGCCAA 3 -- int116Minor allele frequency- G:0.44EA NS NA WA CSA 2273
    rs169680721,2
    C,F--34040128(+) AGCCTA/GTGCTT 3 -- int19Minor allele frequency- G:0.20NA WA CSA EA 500
    rs1160933441,2
    F--34040212(+) AGGAGA/GCTCTG 3 -- int11Minor allele frequency- G:0.01WA 118
    rs1808663091,2
    --34040281(+) GCTGCC/TGTGGT 3 -- int10--------
    rs108539251,2
    C,F,A,H--34040347(+) ATGAAA/TCACCC 3 -- int17Minor allele frequency- T:0.15NS EA CSA WA NA 627
    rs1150403781,2
    --34040413(+) CCCACA/GAGCTG 3 -- int10--------
    rs107755781,2
    C,F,A,H--34040456(+) AGCAGT/GGGCAC 3 -- int110Minor allele frequency- G:0.47NA WA CSA EA 373
    rs1472512361,2
    --34040462(+) GGCACC/TATCTC 3 -- int10--------
    rs616726631,2
    F--34040464(+) CACCAT/ACTCCA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs735843911,2
    C,F--34040515(+) CATCTC/TTGCCG 3 -- int12Minor allele frequency- T:0.04WA 120
    rs1389823781,2
    --34040545(+) CCACCA/GAAGAG 3 -- int10--------
    rs1839704051,2
    C--34040578(+) TTGGGG/TGCCAC 3 -- int10--------
    rs107755791,2
    C,F,A,H--34040614(+) TGGCCC/GCTAGG 3 -- int111Minor allele frequency- G:0.46WA NA CSA EA 374
    rs1161478991,2
    F--34040625(+) AAGGAG/AGCCCT 3 -- int11Minor allele frequency- A:0.01WA 118
    rs1433246771,2
    --34040662(+) GCAGCC/TCACGG 3 -- int10--------
    rs108539261,2
    C,F,A,H--34040665(+) GCCCAC/TGGGTG 3 -- int118Minor allele frequency- T:0.22NS EA NA CSA WA 2336
    rs1475333241,2
    --34040671(+) GGGTGC/TGCCCG 3 -- int10--------
    rs1885051591,2
    --34040790(+) CCTGCC/TCTGGC 3 -- int10--------
    rs1401324901,2
    C--34040808(+) GGGCTC/GGGTTT 3 -- int10--------
    rs1813211791,2
    --34040972(+) AGTGAC/GCTTGG 3 -- int10--------
    rs1506588081,2
    --34041014(+) GGCGCA/GGAGCC 3 -- int10--------
    rs1131391001,2
    C,F--34041021(+) AGCCAG/AAGCCT 3 -- int13Minor allele frequency- A:0.04WA CSA 122
    rs1395283991,2
    --34041041(+) GGTCCC/TGATCA 3 -- int10--------
    rs561346101,2
    C--34041128(+) GCTGGT/CGGAGG 3 -- int11Minor allele frequency- C:0.00WA 2
    rs45943661,2
    C,F,H--34041293(+) TGCACG/AGCTTT 3 -- int18Minor allele frequency- A:0.19NS EA CSA WA NA 739
    rs1489033801,2
    --34041315(+) TGGCT-/GGGGG 
            
    GTTGC
    3 -- int10--------
    rs2010505201,2
    C--34041399(+) CCCCC-/CCCCCC 3 -- int10--------
    rs1166743201,2
    C,F--34041481(+) CGGCCG/ATCCCG 3 -- int12Minor allele frequency- A:0.19WA EA 238
    rs1134408561,2
    C,F--34041486(+) GTCCCG/AGGGTC 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1466683601,2
    --34041519(+) CGTCCC/TGGGGT 3 -- int10--------
    rs1180050331,2
    F--34041520(+) GTCCCG/AGGGTC 3 -- int11Minor allele frequency- A:0.12NA 120
    rs1118093221,2
    C,F--34041539(+) GGCGTC/GGGGGA 3 -- int12Minor allele frequency- G:0.24NA 122
    rs1129911431,2
    C,F--34041580(+) GGGAGG/AGCCCG 3 -- int15Minor allele frequency- A:0.31NA WA CSA 244
    rs1859758051,2
    --34041640(+) AGCCCA/GGGCAG 3 -- int10--------
    rs169680741,2
    C,F,H--34041750(+) GCACAA/GCATCC 3 -- int116Minor allele frequency- G:0.26NA EA NS WA CSA 973
    rs621251661,2
    C,F--34041820(+) TCAGCT/GGCCGC 3 -- int14Minor allele frequency- G:0.29NA 126
    rs2001874871,2
    --34041829(+) CTGGT-/CAAA  
            
    CAAAC
    3 -- int10--------
    rs1115406961,2
    C--34041841(+) GCCCCA/GCCTCC 3 -- int13Minor allele frequency- G:0.22NA WA 240
    rs1174203581,2
    C,F--34041846(+) ACCTCC/TGTGAG 3 -- int11Minor allele frequency- T:0.03NA 120
    rs739297341,2
    C,F--34041902(+) GGGGGT/CTGCTC 3 -- int17Minor allele frequency- C:0.19WA NA CSA EA 365
    rs588651321,2
    C,F--34041949(+) ACCCCG/AGACAG 3 -- int12Minor allele frequency- A:0.24WA 120
    rs1402302321,2
    C--34042022(+) TCACTA/TGTTCC 3 -- int10--------
    rs735843931,2
    C,F--34042317(+) GTCCAT/GCCAGC 3 -- int12Minor allele frequency- G:0.06WA 120
    rs1917398491,2
    --34042486(+) GTGAGC/TGGCTC 3 -- int10--------
    rs81073391,2
    C,F,A,H--34042523(+) CCTCTC/TGGACG 3 -- int123Minor allele frequency- T:0.15NA NS EA WA CSA 2461
    rs1818559761,2
    --34042675(+) CTTCCA/CGGGGG 3 -- int10--------
    rs1401181821,2
    C--34042676(+) TTCCC-/GGGGGC 3 -- int10--------
    rs563610481,2
    C,F--34042723(+) CCCCTT/CGGCGC 3 -- int15Minor allele frequency- C:0.25WA NA CSA 244
    rs1873445441,2
    --34042730(+) GCGCCA/GCTGGT 3 -- int10--------
    rs1441746841,2
    --34042756(+) ACCCTC/GGGGGA 3 -- int10--------
    rs1921198641,2
    --34042795(+) GAGCAA/GGGAGT 3 -- int10--------
    rs1465114531,2
    --34042883(+) GGTTAC/TGACAC 3 -- int10--------
    rs81071001,2
    C,F--34043058(+) TGGAAG/AGCACC 3 -- int11Minor allele frequency- A:0.04NA 120
    rs1155850001,2
    C,F--34043135(+) GCTGCC/TCTGCG 3 -- int11Minor allele frequency- T:0.04WA 118
    rs3766244671,2
    C--34043185(+) TTCCCA/GAAGCA 3 -- int10--------
    rs1820527321,2
    --34043228(+) GCCTGC/GCTCCC 3 -- int10--------
    rs1866885701,2
    --34043239(+) TCCTCC/TGCTGC 3 -- int10--------
    rs1490943011,2
    --34043356(+) TCTCCC/GTCACC 3 -- int10--------
    rs1171601381,2
    C,F--34043459(+) AGCCCG/ATTTTC 3 -- int11Minor allele frequency- A:0.04NA 120
    rs1431393671,2
    --34043545(+) TTCCTA/GTACTT 3 -- int10--------
    rs1899750631,2
    --34043663(+) GTAAAC/TGCCTG 3 -- int10--------
    rs1166402691,2
    C,F--34043726(+) CCCCAT/CCCCCC 3 -- int11Minor allele frequency- C:0.07WA 118
    rs133434431,2
    C,F--34043746(+) TGTACT/CCAGAC 3 -- int16Minor allele frequency- C:0.19NA CSA WA EA 363
    rs72580311,2
    C,F,A,H--34043759(+) TAGAAC/TGGGCA 3 -- int122Minor allele frequency- T:0.37NS EA NA CSA WA 2333
    rs1826106411,2
    --34043868(+) GCCAGC/TGTAGC 3 -- int10--------
    rs1150636551,2
    F--34043908(+) CTCCTC/TAGGCA 3 -- int11Minor allele frequency- T:0.03WA 118
    rs72588631,2
    C,F,A,H--34044050(+) GCAGCA/GTCCTC 3 -- int110Minor allele frequency- G:0.05NS EA WA NA CSA 636
    rs767382871,2
    C,F--34044098(+) GAACAT/CGGCCC 3 -- int12Minor allele frequency- C:0.13NA 122
    rs1121624181,2
    C,F--34044101(+) CATGGC/TCCTCG 3 -- int13Minor allele frequency- T:0.02CSA WA NA 240
    rs1409916731,2
    C--34044105(+) GCCCTC/TGGGAT 3 -- int10--------
    rs81012861,2
    C,F,A--34044118(+) ATGGGA/TGTGAG 3 -- int111Minor allele frequency- T:0.40NA WA CSA EA 372
    rs1880984881,2
    --34044158(+) TCCGGC/TCGGGG 3 -- int10--------
    rs791121931,2
    C,F--34044159(+) CCGGCC/TGGGGT 3 -- int11Minor allele frequency- T:0.03NA 120
    rs1464685831,2
    --34044337(+) TCGAGC/TCTCCT 3 -- int10--------
    rs780063621,2
    F--34044362(+) CAGAGT/CGCCCC 3 -- int11Minor allele frequency- C:0.05WA 118
    rs72457721,2
    C,F,A--34044444(+) CTGAAG/AACAGT 3 -- int18Minor allele frequency- A:0.37NA WA CSA EA 367
    rs1167115221,2
    C,F--34044457(+) TCCCCG/ATCCTG 3 -- int11Minor allele frequency- A:0.05WA 118
    rs72473491,2
    C,F,A,H--34044565(+) CTGACA/CGGAAG 3 -- int125Minor allele frequency- C:0.47NA NS EA WA CSA 2465
    rs72474861,2
    C,F,A,H--34044680(+) GGGGCA/GGGTGC 3 -- int17Minor allele frequency- G:0.39NA WA EA 368
    rs1930817731,2
    --34044681(+) GGGCAA/GGTGCT 3 -- int10--------
    rs749499431,2
    C,F--34044717(+) GTCATC/TCCGCG 3 -- int11Minor allele frequency- T:0.05NA 120
    rs1853384461,2
    --34044722(+) CCCGCA/GCCTCA 3 -- int10--------
    rs1890538421,2
    --34044751(+) GTCAGA/GACTGT 3 -- int10--------
    rs72508691,2
    C,F,A,H--34044810(+) CACATC/TGGCAG 3 -- int113Minor allele frequency- T:0.33NA WA CSA EA 378
    rs72472611,2
    C,F--34044818(+) CAGCAC/GCCCCG 3 -- int11Minor allele frequency- G:0.03NA 120
    rs1925386791,2
    --34044871(+) AGGAGC/TGGGGG 3 -- int10--------
    rs1836528951,2
    --34044873(+) GAGCGA/GGGGAA 3 -- int10--------
    rs609979141,2
    C,F--34044932(+) GTTGAC/TAGGAG 3 -- int11Minor allele frequency- T:0.50WA 2
    rs747133741,2
    C--34044943(+) CTGGG-/CCCCCA 3 -- int11Minor allele frequency- C:0.00CSA 2
    rs1471210661,2
    --34045082(+) CTCTGA/GGGCTT 3 -- int10--------
    rs1883615611,2
    --34045176(+) ACAGCG/TGTGCT 3 -- int10--------
    rs1809554421,2
    --34045194(+) GGAACA/GGCCTT 3 -- int10--------
    rs1383370841,2
    --34045200(+) GCCTTC/TCTGCT 3 -- int10--------
    rs48058781,2
    C,F--34045459(+) GGGTCC/TCCGTC 3 -- int112Minor allele frequency- T:0.36NA WA CSA EA 375
    rs1174907681,2
    C,F--34045489(+) TCCTCG/ACCGAC 3 -- int11Minor allele frequency- A:0.03NA 120
    rs1840388031,2
    --34045726(+) ATTTCC/TGCTGG 3 -- int10--------
    rs124618861,2
    C,F,H--34045727(+) TTTCCG/ACTGGG 3 -- int11Minor allele frequency- A:0.50NA 4
    rs1443408701,2
    --34045796(+) CCATCC/TGGAGG 3 -- int10--------
    rs1896141571,2
    --34045831(+) CCCCAC/TGGGCC 3 -- int10--------
    rs81046061,2
    C,F,H--34045865(+) AGTCCA/GACTCT 3 -- int114Minor allele frequency- G:0.36NA WA CSA EA 380
    rs765040331,2
    F--34045920(+) GGTGTG/TGGGGG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs81055881,2
    C,F,A,H--34045944(+) TGCTCC/TATTCC 3 -- int15Minor allele frequency- T:0.14WA NA EA 362
    rs1487603461,2
    C--34045976(+) CCCCAC/GGCTGG 3 -- int10--------
    rs81061651,2
    C,F,H--34045993(+) GCAGCG/AAAGCC 3 -- int111Minor allele frequency- A:0.35NA WA CSA EA 374
    rs81091911,2
    C,F,H--34046074(+) GGCCTG/TGTGGC 3 -- int113Minor allele frequency- T:0.35NA WA CSA EA 377
    rs1163652871,2
    C--34046109(+) GGCCTA/GTGCCT 3 -- int10--------
    rs735843981,2
    C,F--34046126(+) AGAGTC/GAGCAT 3 -- int12Minor allele frequency- G:0.03WA 120
    rs8891401,2
    C,F,O,H--34046405(-) GTGTTC/TGGTGG 3 -- int133Minor allele frequency- G:0.00EA NA NS WA CSA 2848
    rs1462124311,2
    --34046484(+) GGCACC/TCTGAT 3 -- int10--------
    rs1816143671,2
    --34046564(+) CTTGGC/TGGGCC 3 -- int10--------
    rs1391244301,2
    C--34046572(+) GCCCCC/TGCCCC 3 -- int10--------
    rs1140306811,2
    C,F--34046605(+) TCGCCG/ACTGGG 3 -- int11Minor allele frequency- A:0.04WA 118
    rs104185581,2
    C--34046620(+) TCAGCC/TCCTTG 3 -- int15Minor allele frequency- T:0.25NA CSA WA EA 362
    rs1869684871,2
    --34046651(+) CTGGAC/TATCTG 3 -- int10--------
    rs771348031,2
    --34046673(+) TGCCCA/GTGGAT 3 -- int10--------
    rs1464125221,2
    C--34046688(+) GACACC/TACCAC 3 -- int10--------
    rs1922513381,2
    --34046708(+) TGGTGA/GCACAG 3 -- int10--------
    rs1396386031,2
    --34046770(+) CTGTAC/TGTGAA 3 -- int10--------
    rs8891391,2
    C,F,A,H--34046774(-) ACCCTC/TCACGT 3 -- int130Minor allele frequency- T:0.37NS EA NA WA CSA 2784
    rs1497330191,2
    --34046814(+) CTGTGA/CCCGGC 3 -- int10--------
    rs1819896601,2
    --34046819(+) CCCGGC/TGGAGG 3 -- int10--------
    rs1849921201,2
    --34046937(+) CATTCC/GAGTGA 3 -- int10--------
    rs72565641,2
    C,F,A--34046998(+) AGGAGG/AAGGAG 3 -- int1 trp313Minor allele frequency- A:0.33NA WA CSA EA 375
    rs1455683411,2
    --34047082(+) GAAGAA/GTCAGA 3 -- int10--------
    rs776130101,2
    C,F--34047113(+) CAAGCG/AAACTG 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1154253221,2
    C,F--34047226(+) CTCTGG/ACGCTC 3 -- int11Minor allele frequency- A:0.04WA 118
    rs1466504491,2
    --34047395(+) GTTCAA/GGCGAT 3 -- int10--------
    rs559339411,2
    C--34047396(+) TTCAAG/ACGATT 3 -- int13Minor allele frequency- A:0.07NA WA 240
    rs1478971051,2
    --34047398(+) CAAGCA/GATTCG 3 -- int10--------
    rs20189101,2
    C,F--34047409(-) GGCACG/AAGAAT 3 -- int15Minor allele frequency- A:0.13NA CSA WA EA 362
    rs1896008941,2
    --34047424(+) CCTCCC/TGAGTA 3 -- int10--------
    rs1112869861,2
    C,F--34047571(+) TATAAG/ATGTGA 3 -- int12Minor allele frequency- A:0.03CSA WA 120
    rs774232581,2
    C--34047575(+) AGTGTG/CAGCCA 3 -- int13Minor allele frequency- C:0.20NA EA 242
    rs1822501141,2
    --34047581(+) AGCCAC/TAGAGC 3 -- int10--------
    rs746974861,2
    F--34047587(+) AGAGCC/GCGGCC 3 -- int11Minor allele frequency- G:0.02EA 120
    rs46403011,2
    C,F,A,H--34047633(+) GCTGTT/CTTCCT 3 -- int12Minor allele frequency- C:0.07NA WA 122
    rs126113331,2
    C,F,H--34047654(+) TAAACC/TAGGTG 3 -- int11Minor allele frequency- T:0.50NA 4
    rs349103851,2
    C,F,H--34047700(+) TTGACT/GTTTGG 3 -- int124Minor allele frequency- G:0.17NS EA NA WA CSA 2766
    rs1401124521,2
    C--34047934(+) ACGGT-/GG    
       CTGAG
    GGCCC
    3 -- int10--------
    rs1131463881,2
    C--34047955(+) AAGCAG/-CACTT 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1880922541,2
    --34048109(+) GAGGGC/TGCACT 3 -- int10--------
    rs1911840901,2
    --34048116(+) CACTTA/GGCAGC 3 -- int10--------
    rs1470424941,2
    --34048225(+) TGGGAC/GAGCAG 3 -- int10--------
    rs104063271,2
    C,F,A--34048243(+) TCCTTG/CGCCTG 3 -- int114Minor allele frequency- C:0.49EA NA WA CSA 574
    rs1480751281,2
    --34048308(+) CGGGGC/TACTCT 3 -- int10--------
    rs72489951,2
    C,F--34048336(+) CCTGGA/CCTCTG 3 -- int12Minor allele frequency- C:0.18WA 120
    rs1151065061,2
    C,F--34048403(+) GAGGAC/TGCCTG 3 -- int11Minor allele frequency- T:0.04WA 118
    rs621027181,2
    C,F--34048418(+) CCCCTA/TCACAG 3 -- int17Minor allele frequency- T:0.18NA WA EA 366
    rs1836497781,2
    --34048449(+) TGTCTC/TTCTGG 3 -- int10--------
    rs1420152381,2
    C--34048503(+) GGCAAA/GCTGGG 3 -- int10--------
    rs104055981,2
    C,A,H--34048600(+) GCTGGG/AGCCTG 3 -- int16Minor allele frequency- A:0.28NA WA CSA EA 363
    rs1885263191,2
    C--34048618(+) AGGGCA/GGGCCC 3 -- int10--------
    rs735862051,2
    C,F--34048943(+) GCACAC/TGGTGA 3 -- int11Minor allele frequency- T:0.50WA 2
    rs2010744821,2
    --34049172(+) TCCAC-/AGGCCCTG 3 -- cds10--------
    rs1832883771,2
    --34049339(+) TCAACA/GGCGCG 3 -- int10--------
    rs104254331,2
    C,F,A,H--34049344(+) GGCGCG/ACGGTG 3 -- int18Minor allele frequency- A:0.19NA CSA WA EA 368
    rs671259681,2
    C--34049444(-) GTGTT-/TCTC  
            
    TCTCC
    3 -- int11Minor allele frequency- TCTC:0.00NA 2
    rs1879623901,2
    --34049573(+) GAGTCA/GGCTGC 3 -- int10--------
    rs1502687131,2
    --34049650(+) TGAGCA/GGCACG 3 -- int10--------
    rs1912692061,2
    --34049719(+) ACACCA/GCTTAA 3 -- int10--------
    rs1843666231,2
    --34049760(+) GTGGCC/TAGTGG 3 -- int10--------
    rs8891381,2
    C,F,A,H--34049814(-) ATTGCG/AGGGCT 3 -- int115Minor allele frequency- A:0.49NA EA WA CSA 2047
    rs8765631,2
    C,F,O,A,H--34049886(-) GTGGCG/ATCAGG 3 -- int112Minor allele frequency- A:0.11NA EA CSA WA 2222
    rs1389165851,2
    --34049943(+) CACAAG/TGCAGA 3 -- int10--------
    rs1421220041,2
    --34049955(+) CCGTTC/GCCTGC 3 -- int10--------
    rs1898353911,2
    --34049964(+) GCAGGA/CACCTG 3 -- int10--------
    rs1927861951,2
    C--34049982(+) GCAGCA/GCCCCC 3 -- int10--------
    rs1462244891,2
    C--34049996(+) GCCACA/GTCAGA 3 -- int10--------
    rs2014474451,2
    --34050058(+) CGGCAC/TGGGAG 6 H R mis10--------
    rs2009311121,2
    C--34050086(+) ATAGAC/TGGCCT 6 I V mis10--------
    rs1996219011,2
    C--34050087(+) TAGACG/AGCCTT 6 /A syn11Minor allele frequency- A:0.00EU 913
    rs1392147561,2
    C--34050136(+) AGGTGA/GTGTCG 6 T I mis11Minor allele frequency- G:0.00EU 1185
    rs2015844351,2
    C--34050140(+) GATGTC/TGGAAG 6 N D mis10--------
    rs1424273751,2
    C--34050224(+) TGCCAC/TCGCCC 3 -- int10--------
    rs1438745461,2
    --34050243(+) TTACCA/GCTCCC 3 -- int10--------
    rs1115144291,2
    F--34050302(+) CCCCCT/ACACAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs190098078