External Ids for PENK Gene
Previous GeneCards Identifiers for PENK Gene
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
GeneCards Summary for PENK Gene
PENK (Proenkephalin) is a Protein Coding gene. Diseases associated with PENK include radiculopathy and cannabis dependence. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include neuropeptide hormone activity and opioid peptide activity. An important paralog of this gene is PDYN.
UniProtKB/Swiss-Prot for PENK Gene
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.