External Ids for PENK Gene
Previous GeneCards Identifiers for PENK Gene
GeneCards Summary for PENK Gene
PENK (Proenkephalin) is a Protein Coding gene. Diseases associated with PENK include radiculopathy and diabetic neuropathy. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. GO annotations related to this gene include neuropeptide hormone activity and opioid peptide activity. An important paralog of this gene is PDYN.
UniProtKB/Swiss-Prot for PENK Gene
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum