External Ids for PENK Gene
Previous GeneCards Identifiers for PENK Gene
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
GeneCards Summary for PENK Gene
PENK (Proenkephalin) is a Protein Coding gene. Diseases associated with PENK include Radiculopathy and Cannabis Dependence. Among its related pathways are Peptide ligand-binding receptors and p70S6K Signaling. GO annotations related to this gene include neuropeptide hormone activity and opioid peptide activity. An important paralog of this gene is PDYN.
UniProtKB/Swiss-Prot for PENK Gene
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.