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Aliases for PEMT Gene

Aliases for PEMT Gene

  • Phosphatidylethanolamine N-Methyltransferase 2 3
  • PEMPT 3 4 6
  • PEAMT 3 4
  • PEMT2 3 4
  • PNMT 3 4
  • EC 4
  • EC 4

External Ids for PEMT Gene

Previous GeneCards Identifiers for PEMT Gene

  • GC17M017723
  • GC17M018781
  • GC17M017347
  • GC17M017609
  • GC17M017349
  • GC17M017161

Summaries for PEMT Gene

Entrez Gene Summary for PEMT Gene

  • Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

GeneCards Summary for PEMT Gene

PEMT (Phosphatidylethanolamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with PEMT include whiplash. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphatidyl-N-methylethanolamine N-methyltransferase activity and phosphatidyl-N-dimethylethanolamine N-methyltransferase activity.

UniProtKB/Swiss-Prot for PEMT Gene

  • Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC)

Gene Wiki entry for PEMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEMT Gene

Genomics for PEMT Gene

Regulatory Elements for PEMT Gene

Transcription factor binding sites by QIAGEN in the PEMT gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PEMT Gene

17,505,563 bp from pter
17,591,708 bp from pter
86,146 bases
Minus strand

Genomic View for PEMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PEMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEMT Gene

Proteins for PEMT Gene

  • Protein details for PEMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylethanolamine N-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • A8MZ66
    • B4DY41
    • D3DXC3
    • Q6IAQ5
    • Q86VL3
    • Q9BW86
    • Q9UHY6
    • Q9Y6V9

    Protein attributes for PEMT Gene

    199 amino acids
    Molecular mass:
    22134 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF14867.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PEMT Gene


neXtProt entry for PEMT Gene

Proteomics data for PEMT Gene at MOPED

Post-translational modifications for PEMT Gene

Antibody Products

No data available for DME Specific Peptides for PEMT Gene

Domains for PEMT Gene

Protein Domains for PEMT Gene

Suggested Antigen Peptide Sequences for PEMT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
genes like me logo Genes that share domains with PEMT: view

No data available for Gene Families for PEMT Gene

Function for PEMT Gene

Molecular function for PEMT Gene

GENATLAS Biochemistry:
phosphatidylethanolamine N-methyltransferase,converting phosphatidylethanolamine to phosphatidylcholine,involved in hepatocyte proliferation and liver cancer,with three isoforms differing from each other in the 5 region
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine.
UniProtKB/Swiss-Prot EnzymeRegulation:
The first methylation is rate-limiting
UniProtKB/Swiss-Prot Function:
Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC)

Enzyme Numbers (IUBMB) for PEMT Gene

Gene Ontology (GO) - Molecular Function for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity IEA --
GO:0004608 phosphatidylethanolamine N-methyltransferase activity IEA --
GO:0008170 N-methyltransferase activity --
GO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with PEMT: view
genes like me logo Genes that share phenotypes with PEMT: view

Animal Models for PEMT Gene

MGI Knock Outs for PEMT:

Animal Model Products

miRNA for PEMT Gene

miRTarBase miRNAs that target PEMT

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PEMT

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PEMT Gene

Localization for PEMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEMT Gene

Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250}.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PEMT Gene COMPARTMENTS Subcellular localization image for PEMT gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
plasma membrane 3
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with PEMT: view

Pathways for PEMT Gene

genes like me logo Genes that share pathways with PEMT: view

UniProtKB/Swiss-Prot Q9UBM1-PEMT_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis.

Gene Ontology (GO) - Biological Process for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9989271
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0008283 cell proliferation TAS 9989271
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with PEMT: view

Drugs for PEMT Gene

(2037) HMDB Compounds for PEMT Gene

Compound Synonyms Cas Number PubMed IDs
  • 1,2-Dimyristoyl-rac-glycero-3-phosphocholine
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphocholine
  • 1-Myristoyl-2-pentadecanoyl-sn-glycero-3-phosphocholine
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine

(13) Novoseek inferred chemical compound relationships for PEMT Gene

Compound -log(P) Hits PubMed IDs
phosphatidylethanolamine 88.7 50
phosphatidylcholine 78.1 25
guanidinoacetate 67.8 2
s-adenosylmethionine 67 10
homocysteine 60.2 4
genes like me logo Genes that share compounds with PEMT: view

Transcripts for PEMT Gene

Unigene Clusters for PEMT Gene

Phosphatidylethanolamine N-methyltransferase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PEMT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PEMT Gene

No ASD Table

Relevant External Links for PEMT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PEMT Gene

mRNA expression in normal human tissues for PEMT Gene

mRNA differential expression in normal tissues according to GTEx for PEMT Gene

This gene is overexpressed in Liver (7.7).

Protein differential expression in normal tissues for PEMT Gene

This gene is overexpressed in Liver (30.4), Ovary (12.6), Retina (7.0), and Fetal ovary (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PEMT Gene

SOURCE GeneReport for Unigene cluster for PEMT Gene Hs.714193

genes like me logo Genes that share expressions with PEMT: view

Expression partners for PEMT Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PEMT Gene

Orthologs for PEMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PEMT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PEMT 35
  • 84.42 (n)
  • 80.4 (a)
  • 80 (a)
(Canis familiaris)
Mammalia PEMT 35
  • 86.31 (n)
  • 83.93 (a)
  • 84 (a)
(Mus musculus)
Mammalia Pemt 35
  • 81.07 (n)
  • 80.4 (a)
Pemt 16
Pemt 36
  • 80 (a)
(Pan troglodytes)
Mammalia PEMT 35
  • 98.87 (n)
  • 97.88 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Pemt 35
  • 82.58 (n)
  • 80.9 (a)
(Monodelphis domestica)
Mammalia PEMT 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia PEMT 36
  • 64 (a)
(Gallus gallus)
Aves PEMT 35
  • 70.11 (n)
  • 65.26 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia PEMT 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pemt 35
  • 62.29 (n)
  • 59.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16016 35
(Danio rerio)
Actinopterygii pemt 35
  • 62.6 (n)
  • 60.09 (a)
zgc55479 35
pemt 36
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR431C 35
  • 53.37 (n)
  • 45.21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14234g 35
  • 49.63 (n)
  • 45.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OPI3 35
  • 51.37 (n)
  • 44.33 (a)
OPI3 36
  • 40 (a)
OPI3 38
bread mold
(Neurospora crassa)
Ascomycetes NCU04699 35
  • 55.78 (n)
  • 46.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cho1 35
  • 45.15 (n)
  • 41.27 (a)
Species with no ortholog for PEMT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PEMT Gene

Gene Tree for PEMT (if available)
Gene Tree for PEMT (if available)

Paralogs for PEMT Gene

No data available for Paralogs for PEMT Gene

Variants for PEMT Gene

Sequence variations from dbSNP and Humsavar for PEMT Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7946 - 17,506,246(+) AGCCA(C/T)TATGT missense, reference
rs729974 -- 17,572,253(-) aagag(A/G)caaag intron-variant
rs729975 -- 17,572,154(-) AGAGG(C/T)GGCTT intron-variant
rs744925 -- 17,564,187(-) CACCA(C/T)GGCCC intron-variant
rs746899 -- 17,522,695(+) TCTGG(C/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PEMT Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv907729 CNV Loss 21882294
nsv907730 CNV Loss 21882294
nsv907731 CNV Loss 21882294
dgv3067n71 CNV Loss 21882294
dgv3068n71 CNV Loss 21882294
nsv907737 CNV Loss 21882294
dgv3069n71 CNV Gain+Loss 21882294
dgv3070n71 CNV Loss 21882294
nsv907743 CNV Gain+Loss 21882294
dgv3071n71 CNV Loss 21882294
nsv907745 CNV Loss 21882294
nsv907746 CNV Loss 21882294
nsv907748 CNV Loss 21882294
nsv523094 CNV Loss 19592680
nsv907749 CNV Loss 21882294
nsv524158 CNV Loss 19592680
nsv470579 CNV Loss 18288195
nsv907750 CNV Loss 21882294
nsv833383 CNV Loss 17160897
nsv833384 CNV Loss 17160897

Relevant External Links for PEMT Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PEMT Gene

Disorders for PEMT Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PEMT Gene in MalaCards »

(1) Disease for PEMT Gene

(8) Novoseek inferred disease relationships for PEMT Gene

Disease -log(P) Hits PubMed IDs
choline deficiency 84.4 1
fatty liver 56 5
liver diseases alcoholic 40.9 2
liver diseases 25.6 3
alzheimers disease 15.2 6

Relevant External Links for PEMT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PEMT: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PEMT Gene

Publications for PEMT Gene

  1. Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2. (PMID: 9989271) Walkey C.J. … Vance D.E. (Biochim. Biophys. Acta 1999) 2 3 4 23
  2. Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene. (PMID: 11420179) Shields D.J. … Vance D.E. (Biochim. Biophys. Acta 2001) 3 4 23
  3. Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). (PMID: 16051693) Song J. … Zeisel S.H. (FASEB J. 2005) 3 23 48
  4. Common genetic polymorphisms affect the human requirement for the nutrient choline. (PMID: 16816108) da Costa K.A. … Zeisel S.H. (FASEB J. 2006) 3 23 48
  5. The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population. (PMID: 17391797) Dong H. … Onishi S. (J. Hepatol. 2007) 3 23 48

Products for PEMT Gene

Sources for PEMT Gene

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