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Aliases for PEMT Gene

Aliases for PEMT Gene

  • Phosphatidylethanolamine N-Methyltransferase 2 3 5
  • Phospholipid Methyltransferase 3 4
  • PEAMT 3 4
  • PEMPT 3 4
  • PEMT2 3 4
  • PLMT 3 4
  • PNMT 3 4
  • EC 2.1.1.17 4
  • EC 2.1.1.71 4

External Ids for PEMT Gene

Previous GeneCards Identifiers for PEMT Gene

  • GC17M017723
  • GC17M018781
  • GC17M017347
  • GC17M017609
  • GC17M017349
  • GC17M017161

Summaries for PEMT Gene

Entrez Gene Summary for PEMT Gene

  • Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

GeneCards Summary for PEMT Gene

PEMT (Phosphatidylethanolamine N-Methyltransferase) is a Protein Coding gene. Diseases associated with PEMT include Choline Deficiency Disease and Whiplash. Among its related pathways are Metabolism and Acetylcholine Synthesis. GO annotations related to this gene include N-methyltransferase activity and phosphatidylethanolamine N-methyltransferase activity.

UniProtKB/Swiss-Prot for PEMT Gene

  • Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC).

Gene Wiki entry for PEMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEMT Gene

Genomics for PEMT Gene

Regulatory Elements for PEMT Gene

Enhancers for PEMT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F017522 1 Ensembl ENCODE 23.7 +68.4 68419 1.5 CTCF FEZF1 RAD21 ZIC2 ZNF316 ZFHX2 GLIS2 PRDM10 ZBTB20 EGR2 PEMT RASD1 MED9 KRT16P6 GC17M017508 ENSG00000265511
GH17F017525 0.5 ENCODE 20.3 +65.5 65463 1.4 GATAD2A CEBPA YY1 PEMT RASD1 MED9 ATPAF2 KRT16P6 GC17M017508 PIR49850
GH17F017535 2.1 VISTA FANTOM5 Ensembl ENCODE 15 +53.4 53447 5.2 PKNOX1 MLX ARID4B SIN3A DMAP1 FEZF1 ZNF48 YY1 ZNF121 GLIS2 PEMT GC17M017544 PIR49850
GH17F017565 1.2 FANTOM5 Ensembl ENCODE 14 +24.9 24918 3.5 TFAP4 SAP130 ZIC2 RAD21 RARA YY1 POLR2A NR2F6 GATAD2A ZNF263 PEMT KRT16P6 DRC3 EEF1A1P43 GC17P017579
GH17F017569 0.7 ENCODE 14 +20.3 20328 2.8 MLX ARID4B DMAP1 ZNF48 YY1 ZNF143 PPARG ZNF623 PPARGC1A KAT8 PEMT FAM106A GC17P017579 EEF1A1P43
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PEMT on UCSC Golden Path with GeneCards custom track

Promoters for PEMT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001341944 -192 2201 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for PEMT Gene

Chromosome:
17
Start:
17,505,563 bp from pter
End:
17,591,708 bp from pter
Size:
86,146 bases
Orientation:
Minus strand

Genomic View for PEMT Gene

Genes around PEMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEMT Gene

Proteins for PEMT Gene

  • Protein details for PEMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBM1-PEMT_HUMAN
    Recommended name:
    Phosphatidylethanolamine N-methyltransferase
    Protein Accession:
    Q9UBM1
    Secondary Accessions:
    • A8MZ66
    • B4DY41
    • D3DXC3
    • Q6IAQ5
    • Q86VL3
    • Q9BW86
    • Q9UHY6
    • Q9Y6V9

    Protein attributes for PEMT Gene

    Size:
    199 amino acids
    Molecular mass:
    22134 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF14867.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PEMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PEMT Gene

Post-translational modifications for PEMT Gene

No data available for DME Specific Peptides for PEMT Gene

Domains & Families for PEMT Gene

Protein Domains for PEMT Gene

Suggested Antigen Peptide Sequences for PEMT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBM1

UniProtKB/Swiss-Prot:

PEMT_HUMAN :
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
Family:
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
genes like me logo Genes that share domains with PEMT: view

No data available for Gene Families for PEMT Gene

Function for PEMT Gene

Molecular function for PEMT Gene

GENATLAS Biochemistry:
phosphatidylethanolamine N-methyltransferase,converting phosphatidylethanolamine to phosphatidylcholine,involved in hepatocyte proliferation and liver cancer,with three isoforms differing from each other in the 5 region
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine.
UniProtKB/Swiss-Prot EnzymeRegulation:
The first methylation is rate-limiting.
UniProtKB/Swiss-Prot Function:
Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC).

Enzyme Numbers (IUBMB) for PEMT Gene

Gene Ontology (GO) - Molecular Function for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity IBA --
GO:0004608 phosphatidylethanolamine N-methyltransferase activity TAS --
GO:0008168 methyltransferase activity IEA --
GO:0008170 N-methyltransferase activity IEA --
GO:0008429 phosphatidylethanolamine binding IEA --
genes like me logo Genes that share ontologies with PEMT: view
genes like me logo Genes that share phenotypes with PEMT: view

Animal Models for PEMT Gene

MGI Knock Outs for PEMT:

Animal Model Products

  • Taconic Biosciences Mouse Models for PEMT

miRNA for PEMT Gene

miRTarBase miRNAs that target PEMT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PEMT Gene

Localization for PEMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEMT Gene

Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250}.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEMT Gene COMPARTMENTS Subcellular localization image for PEMT gene
Compartment Confidence
endoplasmic reticulum 4
mitochondrion 4
plasma membrane 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PEMT: view

Pathways & Interactions for PEMT Gene

genes like me logo Genes that share pathways with PEMT: view

UniProtKB/Swiss-Prot Q9UBM1-PEMT_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis.

Gene Ontology (GO) - Biological Process for PEMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9989271
GO:0006644 phospholipid metabolic process IEA --
GO:0006650 glycerophospholipid metabolic process IEA --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006686 sphingomyelin biosynthetic process IEA --
genes like me logo Genes that share ontologies with PEMT: view

No data available for SIGNOR curated interactions for PEMT Gene

Drugs & Compounds for PEMT Gene

(9) Drugs for PEMT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
Phosphatidylethanolamine Experimental Pharma 0
s-adenosylhomocysteine Experimental Pharma 0

(9) Additional Compounds for PEMT Gene - From: Novoseek and HMDB