Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PELP1 Gene

Aliases for PELP1 Gene

  • Proline, Glutamate And Leucine Rich Protein 1 2 3
  • Modulator Of Non-Genomic Activity Of Estrogen Receptor 3 4
  • Transcription Factor HMX3 3 4
  • MNAR 3 4
  • Proline-, Glutamic Acid- And Leucine-Rich Protein 1 3
  • Proline, Glutamic Acid And Leucine Rich Protein 1 2
  • Proline And Glutamic Acid Rich Nuclear Protein 3
  • P160 3
  • HMX3 4

External Ids for PELP1 Gene

Previous GeneCards Identifiers for PELP1 Gene

  • GC17M005003
  • GC17M004920
  • GC17M004525
  • GC17M004781
  • GC17M004521
  • GC17M004574

Summaries for PELP1 Gene

Entrez Gene Summary for PELP1 Gene

  • This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for PELP1 Gene

PELP1 (Proline, Glutamate And Leucine Rich Protein 1) is a Protein Coding gene. Diseases associated with PELP1 include breast cancer. Among its related pathways are GPCR Pathway and Nongenotropic Androgen signaling.

UniProtKB/Swiss-Prot for PELP1 Gene

  • Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PELP1 Gene

Genomics for PELP1 Gene

Regulatory Elements for PELP1 Gene

Genomic Location for PELP1 Gene

Start:
4,671,384 bp from pter
End:
4,704,782 bp from pter
Size:
33,399 bases
Orientation:
Minus strand

Genomic View for PELP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PELP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PELP1 Gene

Proteins for PELP1 Gene

  • Protein details for PELP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZL8-PELP1_HUMAN
    Recommended name:
    Proline-, glutamic acid- and leucine-rich protein 1
    Protein Accession:
    Q8IZL8
    Secondary Accessions:
    • O15450
    • Q5EGN3
    • Q6NTE6
    • Q96FT1
    • Q9BU60

    Protein attributes for PELP1 Gene

    Size:
    1130 amino acids
    Molecular mass:
    119700 Da
    Quaternary structure:
    • Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta-estradiol. Interacts with CREBBP, EP300, AR and NR3C1 in a ligand-dependent manner. Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and another with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Interacts with BCAS3.
    SequenceCaution:
    • Sequence=AAC17708.2; Type=Frameshift; Positions=656, 672; Evidence={ECO:0000305}; Sequence=AAC17708.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for PELP1 Gene

Proteomics data for PELP1 Gene at MOPED

Post-translational modifications for PELP1 Gene

  • Ubiquitination at Lys512
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PELP1 Gene

Domains for PELP1 Gene

Protein Domains for PELP1 Gene

Suggested Antigen Peptide Sequences for PELP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZL8

UniProtKB/Swiss-Prot:

PELP1_HUMAN :
  • Q8IZL8
Domain:
  • The Glu-rich region mediates histones interaction
  • The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1
genes like me logo Genes that share domains with PELP1: view

No data available for Gene Families for PELP1 Gene

Function for PELP1 Gene

Molecular function for PELP1 Gene

UniProtKB/Swiss-Prot Function: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Ontology (GO) - Molecular Function for PELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17505058
GO:0005488 binding --
GO:0005515 protein binding IPI 16169070
GO:0008134 transcription factor binding IPI 17505058
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PELP1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PELP1 Gene

Localization for PELP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PELP1 Gene

Nucleus, nucleoplasm. Nucleus. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PELP1 Gene COMPARTMENTS Subcellular localization image for PELP1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PELP1: view

Pathways for PELP1 Gene

genes like me logo Genes that share pathways with PELP1: view

Gene Ontology (GO) - Biological Process for PELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 17505058
GO:0071391 cellular response to estrogen stimulus IDA 17505058
genes like me logo Genes that share ontologies with PELP1: view

Compounds for PELP1 Gene

(14) Novoseek inferred chemical compound relationships for PELP1 Gene

Compound -log(P) Hits PubMed IDs
estrogen 72.2 50
proline 64.2 18
steroid 61.3 24
testosterone 48.7 9
retinoic acid 46.5 5
genes like me logo Genes that share compounds with PELP1: view

Transcripts for PELP1 Gene

Unigene Clusters for PELP1 Gene

Proline, glutamate and leucine rich protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PELP1 Gene

No ASD Table

Relevant External Links for PELP1 Gene

GeneLoc Exon Structure for
PELP1
ECgene alternative splicing isoforms for
PELP1

Expression for PELP1 Gene

mRNA expression in normal human tissues for PELP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PELP1 Gene

SOURCE GeneReport for Unigene cluster for PELP1 Gene Hs.744899

mRNA Expression by UniProt/SwissProt for PELP1 Gene

Q8IZL8-PELP1_HUMAN
Tissue specificity: Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed.
genes like me logo Genes that share expressions with PELP1: view

No data available for mRNA differential expression in normal tissues for PELP1 Gene

Orthologs for PELP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PELP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PELP1 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PELP1 35
  • 86.67 (n)
  • 90.19 (a)
PELP1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PELP1 35
  • 86.69 (n)
  • 92.42 (a)
PELP1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pelp1 35
  • 84.84 (n)
  • 88.12 (a)
Pelp1 16
Pelp1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PELP1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PELP1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pelp1 35
  • 85.2 (n)
  • 87.88 (a)
lizard
(Anolis carolinensis)
Reptilia PELP1 36
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20939 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
PELP1 36
  • 41 (a)
OneToOne
Species with no ortholog for PELP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PELP1 Gene

ENSEMBL:
Gene Tree for PELP1 (if available)
TreeFam:
Gene Tree for PELP1 (if available)

Paralogs for PELP1 Gene

No data available for Paralogs for PELP1 Gene

Variants for PELP1 Gene

Sequence variations from dbSNP and Humsavar for PELP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9436 - 4,671,456(-) CTCCC(A/T)CAGAG reference, missense
rs906452 -- 4,691,673(-) TGGGG(C/T)ATGGA intron-variant
rs906453 -- 4,691,670(-) GGCAT(A/G)GAGGG intron-variant
rs906454 -- 4,691,642(-) TAACT(C/T)GAGGA intron-variant
rs931908 -- 4,677,537(-) TACAA(G/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PELP1 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897

Relevant External Links for PELP1 Gene

HapMap Linkage Disequilibrium report
PELP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PELP1 Gene

Disorders for PELP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PELP1 Gene including...

Search for PELP1 Gene in MalaCards »

(5) Novoseek inferred disease relationships for PELP1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 45 13
breast carcinoma 25.8 1
necrosis 0 1
tumors 0 21
cancer 0 7

Relevant External Links for PELP1

Genetic Association Database (GAD)
PELP1
Human Genome Epidemiology (HuGE) Navigator
PELP1
genes like me logo Genes that share disorders with PELP1: view

No data available for UniProtKB/Swiss-Prot for PELP1 Gene

Publications for PELP1 Gene

  1. Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. (PMID: 11481323) Vadlamudi R.K. … Kumar R. (J. Biol. Chem. 2001) 2 3 4 23
  2. Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. (PMID: 12682072) Balasenthil S. … Vadlamudi R.K. (J. Biol. Chem. 2003) 2 3 4 23
  3. Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc. (PMID: 14963108) Barletta F. … Cheskis B.J. (Mol. Endocrinol. 2004) 3 4 23
  4. Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells. (PMID: 15374949) Nair S.S. … Vadlamudi R.K. (Cancer Res. 2004) 3 4 23
  5. 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. (PMID: 16574651) Singh R.R. … Kumar R. (J. Biol. Chem. 2006) 3 4 23

Products for PELP1 Gene

Sources for PELP1 Gene

Back to Top

Content