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Aliases for PELP1 Gene

Aliases for PELP1 Gene

  • Proline, Glutamate And Leucine Rich Protein 1 2 3
  • Modulator Of Non-Genomic Activity Of Estrogen Receptor 3 4
  • Transcription Factor HMX3 3 4
  • MNAR 3 4
  • Proline, Glutamic Acid And Leucine Rich Protein 1 2
  • Proline And Glutamic Acid Rich Nuclear Protein 3
  • P160 3
  • HMX3 4

External Ids for PELP1 Gene

Previous GeneCards Identifiers for PELP1 Gene

  • GC17M005003
  • GC17M004920
  • GC17M004525
  • GC17M004781
  • GC17M004521
  • GC17M004574

Summaries for PELP1 Gene

Entrez Gene Summary for PELP1 Gene

  • This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for PELP1 Gene

PELP1 (Proline, Glutamate And Leucine Rich Protein 1) is a Protein Coding gene. Diseases associated with PELP1 include breast cancer. Among its related pathways are GPCR Pathway and Nongenotropic Androgen signaling. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for PELP1 Gene

  • Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PELP1 Gene

Genomics for PELP1 Gene

Regulatory Elements for PELP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PELP1 Gene

Chromosome:
17
Start:
4,669,774 bp from pter
End:
4,704,337 bp from pter
Size:
34,564 bases
Orientation:
Minus strand

Genomic View for PELP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PELP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PELP1 Gene

Proteins for PELP1 Gene

  • Protein details for PELP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZL8-PELP1_HUMAN
    Recommended name:
    Proline-, glutamic acid- and leucine-rich protein 1
    Protein Accession:
    Q8IZL8
    Secondary Accessions:
    • O15450
    • Q5EGN3
    • Q6NTE6
    • Q96FT1
    • Q9BU60

    Protein attributes for PELP1 Gene

    Size:
    1130 amino acids
    Molecular mass:
    119700 Da
    Quaternary structure:
    • Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta-estradiol. Interacts with CREBBP, EP300, AR and NR3C1 in a ligand-dependent manner. Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and another with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Interacts with BCAS3.
    SequenceCaution:
    • Sequence=AAC17708.2; Type=Frameshift; Positions=656, 672; Evidence={ECO:0000305}; Sequence=AAC17708.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for PELP1 Gene

Proteomics data for PELP1 Gene at MOPED

Post-translational modifications for PELP1 Gene

  • Ubiquitination at Lys 512
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PELP1 (PELP1)

No data available for DME Specific Peptides for PELP1 Gene

Domains & Families for PELP1 Gene

Protein Domains for PELP1 Gene

Suggested Antigen Peptide Sequences for PELP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZL8

UniProtKB/Swiss-Prot:

PELP1_HUMAN :
  • The Glu-rich region mediates histones interaction
Domain:
  • The Glu-rich region mediates histones interaction
  • The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1
genes like me logo Genes that share domains with PELP1: view

No data available for Gene Families for PELP1 Gene

Function for PELP1 Gene

Molecular function for PELP1 Gene

UniProtKB/Swiss-Prot Function:
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Gene Ontology (GO) - Molecular Function for PELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17505058
GO:0005488 binding --
GO:0005515 protein binding IPI 16169070
GO:0008134 transcription factor binding IPI 17505058
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PELP1: view

Phenotypes for PELP1 Gene

genes like me logo Genes that share phenotypes with PELP1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PELP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PELP1 Gene

Localization for PELP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PELP1 Gene

Nucleus, nucleoplasm. Nucleus. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PELP1 Gene COMPARTMENTS Subcellular localization image for PELP1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PELP1: view

Pathways & Interactions for PELP1 Gene

genes like me logo Genes that share pathways with PELP1: view

Pathways by source for PELP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PELP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PELP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 17505058
GO:0071391 cellular response to estrogen stimulus IDA 17505058
genes like me logo Genes that share ontologies with PELP1: view

Drugs & Compounds for PELP1 Gene

(10) Drugs for PELP1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational Pharma Sex hormone 1057
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 341
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
estrogen Pharma 0
alanine Nutra 97

(4) Additional Compounds for PELP1 Gene - From: NovoSeek

genes like me logo Genes that share compounds with PELP1: view

Transcripts for PELP1 Gene

Unigene Clusters for PELP1 Gene

Proline, glutamate and leucine rich protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PELP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PELP1 Gene

No ASD Table

Relevant External Links for PELP1 Gene

GeneLoc Exon Structure for
PELP1
ECgene alternative splicing isoforms for
PELP1

Expression for PELP1 Gene

mRNA expression in normal human tissues for PELP1 Gene

Protein differential expression in normal tissues from HIPED for PELP1 Gene

This gene is overexpressed in Fetal ovary (7.4), Liver (7.0), and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PELP1 Gene



SOURCE GeneReport for Unigene cluster for PELP1 Gene Hs.744899

mRNA Expression by UniProt/SwissProt for PELP1 Gene

Q8IZL8-PELP1_HUMAN
Tissue specificity: Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed.
genes like me logo Genes that share expression patterns with PELP1: view

Protein tissue co-expression partners for PELP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PELP1 Gene

Orthologs for PELP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PELP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PELP1 35
  • 86.67 (n)
  • 90.19 (a)
PELP1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PELP1 35
  • 86.69 (n)
  • 92.42 (a)
PELP1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pelp1 35
  • 84.84 (n)
  • 88.12 (a)
Pelp1 16
Pelp1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pelp1 35
  • 85.2 (n)
  • 87.88 (a)
oppossum
(Monodelphis domestica)
Mammalia PELP1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PELP1 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PELP1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PELP1 36
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20939 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
PELP1 36
  • 41 (a)
OneToOne
Species with no ortholog for PELP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PELP1 Gene

ENSEMBL:
Gene Tree for PELP1 (if available)
TreeFam:
Gene Tree for PELP1 (if available)

Paralogs for PELP1 Gene

No data available for Paralogs for PELP1 Gene

Variants for PELP1 Gene

Sequence variations from dbSNP and Humsavar for PELP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9436 - 4,671,456(-) CTCCC(A/T)CAGAG reference, missense
rs906452 -- 4,691,673(-) TGGGG(C/T)ATGGA intron-variant
rs906453 -- 4,691,670(-) GGCAT(A/G)GAGGG intron-variant
rs906454 -- 4,691,642(-) TAACT(C/T)GAGGA intron-variant
rs931908 -- 4,677,537(-) TACAA(G/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PELP1 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897

Variation tolerance for PELP1 Gene

Residual Variation Intolerance Score: 43.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 71.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PELP1 Gene

HapMap Linkage Disequilibrium report
PELP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PELP1 Gene

Disorders for PELP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PELP1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association
Search PELP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PELP1

Genetic Association Database (GAD)
PELP1
Human Genome Epidemiology (HuGE) Navigator
PELP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PELP1
genes like me logo Genes that share disorders with PELP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PELP1 Gene

Publications for PELP1 Gene

  1. Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. (PMID: 12682072) Balasenthil S. … Vadlamudi R.K. (J. Biol. Chem. 2003) 2 23 67
  2. Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. (PMID: 11481323) Vadlamudi R.K. … Kumar R. (J. Biol. Chem. 2001) 2 23 67
  3. PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity. (PMID: 20448663) Nair S.S. … Vadlamudi R.K. (EMBO Rep. 2010) 23 67
  4. Breast cancer-derived M543V mutation in helix 12 of estrogen receptor alpha inverts response to estrogen and SERMs. (PMID: 19526339) Nichols M. … McCarty K.S. (Breast Cancer Res. Treat. 2010) 23 67
  5. The interaction between thymine DNA glycosylase and nuclear receptor coactivator 3 is required for the transcriptional activation of nuclear hormone receptors. (PMID: 19652917) Chiang S. … He R. (Mol. Cell. Biochem. 2010) 23 67

Products for PELP1 Gene

Sources for PELP1 Gene

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