PELP1 Gene
protein-coding GIFtS: 51
GCID: GC17M004574
|
|
proline, glutamate and leucine rich protein 1(Previous names: proline, glutamic acid and leucine rich protein 1 )
| |
Aliases
for PELP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Proline, Glutamate And Leucine Rich Protein 11 2 | | P1602 | | MNAR1 2 3 | | Modulator Of Nongenomic Activity Of Estrogen Receptor2 | | Proline, Glutamic Acid And Leucine Rich Protein 11 2 | | Proline And Glutamic Acid Rich Nuclear Protein2 | | Modulator Of Non-Genomic Activity Of Estrogen Receptor2 3 | | Proline-, Glutamic Acid- And Leucine-Rich Protein 12 | | Transcription Factor HMX32 3 | | Proline-, Glutamic Acid-, Leucine-Rich Protein 12 | | HMX32 3 | | |
Export aliases for PELP1 gene to outside databasesPrevious GC identifers: GC17M005003 GC17M004920 GC17M004525 GC17M004781 GC17M004521 |
Summaries
for PELP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PELP1:
This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes andcorepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of thisgene is regulated by both members of the estrogen receptor family. Alternative splicing results in multiple transcriptvariants. (provided by RefSeq, Feb 2012)
UniProtKB/Swiss-Prot: PELP1_HUMAN, Q8IZL8Function: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptorsand sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present inthe nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitateER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycleprogression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk.Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptorsignaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation ofseveral oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability tomodulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as thekey stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited toZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes
|
Genomic Views
for PELP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PELP1 gene promoter:
COUP-TF1 COUP-TF AP-1 ATF-2 COUP c-Jun HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PELP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PELP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2PELP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M004574: view genomic region
(about GC identifiers)
Start:
|
4,574,679 bp from pter |
End:
|
4,607,632 bp from pter |
Size:
|
32,954 bases |
Orientation:
|
minus strand |
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Proteins
for PELP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PELP1_HUMAN, Q8IZL8 (See
protein sequence)Recommended Name: Proline-, glutamic acid- and leucine-rich protein 1 Size: 1130 amino acids; 119700 Da
Subunit: Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm.Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta-estradiol. Interacts with CREBBP, EP300, ARand NR3C1 in a ligand-dependent manner. Forms two complexes in the presence of 17-beta-estradiol; one with SRC andESR1 and another with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of someMLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as thefacultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20,PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Core component of the 5FMCcomplex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP andZNF148. Interacts with NOL9
Subcellular location: Nucleus, nucleoplasm (By similarity). Nucleus. Cytoplasm. Note=Mainly found in the nucleoplasm,with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly incytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantlycytoplasm localization in high-grade endometrial tumors
Sequence caution: Sequence=AAC17708.2; Type=Frameshift; Positions=656, 672;
Secondary accessions: O15450 Q5EGN3 Q6NTE6 Q96FT1 Q9BU60Alternative splicing: 2 isoforms: Q8IZL8-1 Q8IZL8-2 Explore the universe of human proteins at neXtProt for PELP1: NX_Q8IZL8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZL8
PELP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055204.2
ENSEMBL proteins: ENSP00000461625 ENSP00000460300 ENSP00000461380 ENSP00000460959 ENSP00000461419 ENSP00000458985 ENSP00000461283 ENSP00000301396 ENSP00000269230 ENSP00000416231
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PELP1 for ontologies About GeneDecksing
PELP1 Antibody Products:
Assay Products for PELP1: |
Protein
Domains /
Families
for PELP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PELP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IZL8ProtoNet protein and cluster: Q8IZL8 2 Blocks protein families: IPB012583 NUC201 IPB012980 Protein of unknown function NUC202
UniProtKB/Swiss-Prot: PELP1_HUMAN, Q8IZL8Domain: The Glu-rich region mediates histones interactionDomain: The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1 |
Function
for PELP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PELP1_HUMAN, Q8IZL8Function: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptorsand sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present inthe nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitateER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycleprogression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk.Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptorsignaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation ofseveral oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability tomodulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as thekey stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited toZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PELP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PELP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PELP1 (NM_014389) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PELP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PELP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PELP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
PELP1 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Pelp1 (no phenotypes)
PELP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PELP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MNAR-PELP1 and Estrogen Receptor Interaction | | | 2 | Coregulation of Androgen receptor activity | | | 3 | Nongenotropic Androgen signaling | | | 4 | Plasma membrane estrogen receptor signaling | | | 5 | GPCR Pathway | |
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PELP1
3  BioSystems Pathways for PELP1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PELP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/712 Interacting proteins for PELP1 (Q8IZL81, 2, 3 ENSP000003013964) via UniProtKB, MINT, STRING, and/or I2D (see all 712)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
PELP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PELP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PELP1 for compounds About GeneDecksing
 Browse Tocris compounds for PELP1
10/14 Novoseek chemical compound relationships for PELP1 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| estrogen |
72.2 |
73 |
15374949 (4), 19276281 (3), 11481323 (3), 15087130 (3) (see all 33) |
| proline |
64.2 |
22 |
11481323 (2), 17505058 (2), 18079323 (1), 16574651 (1) (see all 16) |
| steroid |
61.3 |
27 |
11301320 (2), 10598588 (1), 14722092 (1), 14766010 (1) (see all 23) |
| testosterone |
48.7 |
14 |
11551963 (3), 10601285 (2), 12588987 (1), 19828458 (1) (see all 6) |
| retinoic acid |
46.5 |
6 |
16574651 (2), 10598588 (1), 11010967 (1), 12149266 (1) |
| tamoxifen |
43.8 |
8 |
10986290 (2), 16505095 (2), 19470742 (2), 17804729 (1) |
| glutamate |
43.1 |
21 |
11481323 (2), 17505058 (2), 16574651 (1), 16270355 (1) (see all 15) |
| arginine |
19.9 |
4 |
11050077 (1), 10381882 (1), 11850402 (1), 15731352 (1) |
| retinoid |
15.4 |
1 |
15731352 (1) |
| estradiol |
12.2 |
1 |
11477071 (1) |
Search CenterWatch for drugs/clinical trials and news about PELP1
|
Transcripts
for PELP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PELP1 gene: NM_014389.2 Unigene Cluster for PELP1: Proline, glutamate and leucine rich protein 1 Hs.513883 [show with all ESTs]Unigene Representative Sequence: NM_01438917 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000574876 ENST00000572293 ENST00000573523 ENST00000575329 ENST00000573242
ENST00000575534 ENST00000570571 ENST00000573506 ENST00000570387 ENST00000575101
ENST00000575342 ENST00000571170 ENST00000570823 ENST00000571347 ENST00000301396(uc002fyi.4 uc010vsf.2)
ENST00000269230 ENST00000436683
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PELP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PELP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PELP1 (NM_014389) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PELP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PELP1 |
Additional cDNA sequence: AF547989.1 AK226056.1 AK291163.1 AK293838.1 AK299084.1 AY882602.1 BC002875.2 BC010457.2 BC039131.1 BC069058.1 NR_046388.1 U88154.1 15 DOTS entries: DT.412511 DT.100785487 DT.86847447 DT.92435904 DT.100785485 DT.92435903 DT.95307121 DT.100785484 DT.121012373 DT.121012377 DT.95180350 DT.100030239 DT.100894725 DT.91968294 DT.97849079 24/230 AceView cDNA sequences (see all 230): BU557352 BQ643296 BC069058 BU552840 BM477647 BU508444 BQ057517 BQ063511 BQ065499 BQ643132 BU556489 BU553659 BC002875 BQ065593 BQ066166 BU859236 BE672131 AI635967 BQ710933 BQ062310 BE466720 BU553642 BQ056877 BI861165
GeneLoc Exon Structure
|
Expression
for PELP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PELP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCCGACT
About this image
See PELP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PELP1
SOURCE GeneReport for Unigene cluster: Hs.513883
UniProtKB/Swiss-Prot: PELP1_HUMAN, Q8IZL8Tissue specificity: Isoform 2 is expressed in breast cancer cell lines. Isoform 1 is widely expressed
SABiosciences Expression via Pathway-Focused PCR Array including PELP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PELP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PELP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PELP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PELP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PELP1 |
Orthologs
for PELP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PELP1 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pelp11 , 5 |
proline, glutamic acid and leucine rich protein 11, 5 |
85.11(n)1
87.91(a)1 |
|
11 (42.99 cM)5
752731 NM_029231.41 NP_083507.31
703928835 |
lizard
(Anolis carolinensis) |
Reptilia |
PELP16 |
-- |
49(a) |
1 ↔ 1 |
GL344863.1(9130-14030) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.209392 |
Xenopus laevis transcribed sequence with weak similarity more |
82.19(n) |
|
BU152760.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AI544939.12 |
-- |
74.39(n) |
|
322664 AI544939.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG332171 |
CG33217 |
34.55(n)
20.68(a) |
|
2768951 NM_206425.2 NP_996147.1 |
ENSEMBL Gene Tree for PELP1 (if available)
TreeFam Gene Tree for PELP1 (if available) |
Paralogs
for PELP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PELP1 gene
- CCER12
PELP1 for paralogs About GeneDecksing
|
Genomic Variants
for PELP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PELP1 (4574679 - 4607632 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PELP1
1 CNV: 4985 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PELP1 |
|
Disorders
/ Diseases
for PELP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PELP1 for disorders About GeneDecksing
OMIM gene information: 609455
OMIM disorders: --
16  diseases for PELP1: About MalaCardspasteurellosis breast cancer susceptibility sporadic breast cancer breast cancer
retinoblastoma pancreatic cancer colorectal cancer lung cancer
prostate cancer pancreatitis carcinoma prostatitis
immunodeficiency thyroiditis melanoma adenocarcinoma
5 Novoseek disease relationships for PELP1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: PELP1 (2 documents)
Export disorders for PELP1 gene to outside databases
|
Publications
for PELP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PELP1 gene, integrated from 9 sources (see all 166):
(articles sorted by number of sources associating them with PELP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. (PubMed id 11481323)1, 2, 3, 9 Vadlamudi R.K....Kumar R. (2001)
- Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. (PubMed id 12682072)1, 2, 3, 9 Balasenthil S. and Vadlamudi R.K. (2003)
- Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells. (PubMed id 15374949)1, 2, 9 Nair S.S....Vadlamudi R.K. (2004)
- Functional implications of altered subcellular localization of PELP1 in breast cancer cells. (PubMed id 16140940)1, 2, 9 Vadlamudi R.K.... Kumar R. (2005)
- 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. (PubMed id 16574651)1, 2, 9 Singh R.R.... Kumar R. (2006)
- Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc. (PubMed id 14963108)1, 2, 9 Barletta F....Cheskis B.J. (2004)
- Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK. (PubMed id 16352611)1, 2 Rayala S.K.... Kumar R. (2006)
- NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. (PubMed id 16567619)1, 2 Rosendorff A.... Gill G. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
|
External Searches for PELP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PELP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PELP1 gene
(According to HUGE)
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Specialized Databases showing PELP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PELP1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for PELP1 gene:
Search GeneIP for patents involving PELP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PELP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PELP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PELP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PELP1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PELP1 | | OriGene 3'-UTR Clone for PELP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PELP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PELP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PELP1 | | OriGene Custom Protein Services for PELP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PELP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PELP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PELP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PELP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PELP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PELP1 |
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| | | | Search Tocris compounds for PELP1 |
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 | | | PELP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PELP1 |
|  |  |  | | | | ThermoFisher Antibodies for PELP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PELP1 |
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