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Aliases for PELO Gene

Aliases for PELO Gene

  • Pelota Homolog (Drosophila) 2 3
  • Pelota (Drosophila) Homolog 2
  • EC 3.1.-.- 4
  • PRO1770 3
  • CGI-17 3

External Ids for PELO Gene

Previous GeneCards Identifiers for PELO Gene

  • GC05P052248
  • GC05P053513
  • GC05P052054
  • GC05P052100
  • GC05P052101
  • GC05P052120
  • GC05P052084
  • GC05P049055

Summaries for PELO Gene

Entrez Gene Summary for PELO Gene

  • This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]

GeneCards Summary for PELO Gene

PELO (Pelota Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are Focal adhesion and mRNA surveillance pathway. GO annotations related to this gene include endonuclease activity.

UniProtKB/Swiss-Prot for PELO Gene

  • Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).

Gene Wiki entry for PELO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PELO Gene

Genomics for PELO Gene

Regulatory Elements for PELO Gene

Genomic Location for PELO Gene

Chromosome:
5
Start:
52,787,940 bp from pter
End:
52,804,046 bp from pter
Size:
16,107 bases
Orientation:
Plus strand

Genomic View for PELO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PELO Gene

Proteins for PELO Gene

  • Protein details for PELO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX2-PELO_HUMAN
    Recommended name:
    Protein pelota homolog
    Protein Accession:
    Q9BRX2
    Secondary Accessions:
    • Q9GZS6
    • Q9Y306

    Protein attributes for PELO Gene

    Size:
    385 amino acids
    Molecular mass:
    43359 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PELO Gene

neXtProt entry for PELO Gene

Proteomics data for PELO Gene at MOPED

Post-translational modifications for PELO Gene

  • Ubiquitination at Lys 46, Lys 162, and Lys 254
  • Modification sites at PhosphoSitePlus

Other Protein References for PELO Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PELO Gene

Domains & Families for PELO Gene

Protein Domains for PELO Gene

Suggested Antigen Peptide Sequences for PELO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRX2

UniProtKB/Swiss-Prot:

PELO_HUMAN :
  • The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential).
  • Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
Domain:
  • The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential).
Family:
  • Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
genes like me logo Genes that share domains with PELO: view

No data available for Gene Families for PELO Gene

Function for PELO Gene

Molecular function for PELO Gene

UniProtKB/Swiss-Prot Function:
Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).

Enzyme Numbers (IUBMB) for PELO Gene

Gene Ontology (GO) - Molecular Function for PELO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PELO: view
genes like me logo Genes that share phenotypes with PELO: view

Animal Models for PELO Gene

MGI Knock Outs for PELO:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PELO

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PELO Gene

Localization for PELO Gene

Subcellular locations from UniProtKB/Swiss-Prot for PELO Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PELO Gene COMPARTMENTS Subcellular localization image for PELO gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PELO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PELO: view

Pathways & Interactions for PELO Gene

genes like me logo Genes that share pathways with PELO: view

Pathways by source for PELO Gene

1 BioSystems pathway for PELO Gene
1 KEGG pathway for PELO Gene

Gene Ontology (GO) - Biological Process for PELO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008283 cell proliferation IEA --
GO:0051276 chromosome organization IEA --
GO:0051301 cell division IEA --
GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay IEA --
genes like me logo Genes that share ontologies with PELO: view

No data available for SIGNOR curated interactions for PELO Gene

Drugs & Compounds for PELO Gene

No Compound Related Data Available

Transcripts for PELO Gene

mRNA/cDNA for PELO Gene

Unigene Clusters for PELO Gene

Pelota homolog (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PELO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PELO Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1:
SP2: - - - - - -
SP3: - - - -
SP4:
SP5:
SP6: - - -
SP7: - - - - -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PELO Gene

GeneLoc Exon Structure for
PELO
ECgene alternative splicing isoforms for
PELO

Expression for PELO Gene

mRNA expression in normal human tissues for PELO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PELO Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8), Breast (8.4), and Pancreas (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PELO Gene



SOURCE GeneReport for Unigene cluster for PELO Gene Hs.644352

mRNA Expression by UniProt/SwissProt for PELO Gene

Q9BRX2-PELO_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with PELO: view

Protein tissue co-expression partners for PELO Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PELO Gene

Orthologs for PELO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PELO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PELO 35
  • 93.33 (n)
  • 98.44 (a)
PELO 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PELO 35
  • 93.16 (n)
  • 97.92 (a)
mouse
(Mus musculus)
Mammalia Pelo 35
  • 90.22 (n)
  • 96.88 (a)
Pelo 16
Pelo 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pelo 35
  • 91.69 (n)
  • 97.14 (a)
chimpanzee
(Pan troglodytes)
Mammalia PELO 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves PELO 35
  • 83.2 (n)
  • 93.77 (a)
lizard
(Anolis carolinensis)
Reptilia PELO 36
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pelo 35
  • 72.38 (n)
  • 82.08 (a)
pelo 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pelo 37
  • 67 (a)
pelo 35
  • 63.41 (n)
  • 66.75 (a)
pelo 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008269 35
  • 63.96 (n)
  • 67.84 (a)
worm
(Caenorhabditis elegans)
Secernentea R74.6 37
  • 58 (a)
R74.6 35
  • 56.08 (n)
  • 58.27 (a)
R74.6 36
  • 58 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOM34 36
  • 35 (a)
OneToOne
DOM34 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC18B5.06 35
  • 52.41 (n)
  • 49.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for PELO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PELO Gene

ENSEMBL:
Gene Tree for PELO (if available)
TreeFam:
Gene Tree for PELO (if available)

Paralogs for PELO Gene

No data available for Paralogs for PELO Gene

Variants for PELO Gene

Sequence variations from dbSNP and Humsavar for PELO Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_019777 -

Structural Variations from Database of Genomic Variants (DGV) for PELO Gene

Variant ID Type Subtype PubMed ID
nsv462187 CNV Gain 19166990
nsv471013 CNV Gain 18288195
nsv830295 CNV Gain 17160897

Variation tolerance for PELO Gene

Residual Variation Intolerance Score: 31.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PELO Gene

HapMap Linkage Disequilibrium report
PELO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PELO Gene

Disorders for PELO Gene

Relevant External Links for PELO

Genetic Association Database (GAD)
PELO
Human Genome Epidemiology (HuGE) Navigator
PELO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PELO
genes like me logo Genes that share disorders with PELO: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PELO Gene

Publications for PELO Gene

  1. Molecular cloning, expression and chromosome location of the human pelota gene PELO. (PMID: 11060452) Shamsadin R. … Engel W. (Cytogenet. Cell Genet. 2000) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67

Products for PELO Gene

Sources for PELO Gene

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