Aliases for PELI2 Gene
External Ids for PELI2 Gene
GeneCards Summary for PELI2 Gene
PELI2 (Pellino E3 Ubiquitin Protein Ligase Family Member 2) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Toll Like Receptor 7/8 (TLR7/8) Cascade. GO annotations related to this gene include ligase activity. An important paralog of this gene is PELI3.
UniProtKB/Swiss-Prot for PELI2 Gene
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 Lys-63-linked polyubiquitination and possibly Lys-48-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.