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Aliases for PELI2 Gene

Aliases for PELI2 Gene

  • Pellino E3 Ubiquitin Protein Ligase Family Member 2 2 3 5
  • Pellino-2 3 4
  • E3 Ubiquitin-Protein Ligase Pellino Homolog 2 3
  • Pellino (Drosophila) Homolog 2 2
  • Pellino Homolog 2 (Drosophila) 2
  • Protein Pellino Homolog 2 3
  • Pellino Homolog 2 3
  • EC 6.3.2.- 4

External Ids for PELI2 Gene

Previous GeneCards Identifiers for PELI2 Gene

  • GC14P053909
  • GC14P050381
  • GC14P054575
  • GC14P055654
  • GC14P056585
  • GC14P036750

Summaries for PELI2 Gene

GeneCards Summary for PELI2 Gene

PELI2 (Pellino E3 Ubiquitin Protein Ligase Family Member 2) is a Protein Coding gene. Among its related pathways are MyD88 cascade initiated on plasma membrane and IRAK1 recruits IKK complex. GO annotations related to this gene include ligase activity. An important paralog of this gene is PELI1.

UniProtKB/Swiss-Prot for PELI2 Gene

  • E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 Lys-63-linked polyubiquitination and possibly Lys-48-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Gene Wiki entry for PELI2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PELI2 Gene

Genomics for PELI2 Gene

Regulatory Elements for PELI2 Gene

Enhancers for PELI2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PELI2 on UCSC Golden Path with GeneCards custom track

Promoters for PELI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PELI2 Gene

Chromosome:
14
Start:
56,117,814 bp from pter
End:
56,301,581 bp from pter
Size:
183,768 bases
Orientation:
Plus strand

Genomic View for PELI2 Gene

Genes around PELI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PELI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PELI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PELI2 Gene

Proteins for PELI2 Gene

  • Protein details for PELI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAT8-PELI2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase pellino homolog 2
    Protein Accession:
    Q9HAT8
    Secondary Accessions:
    • B2RDY5

    Protein attributes for PELI2 Gene

    Size:
    420 amino acids
    Molecular mass:
    46435 Da
    Quaternary structure:
    • Interacts with TRAF6, IRAK1, IRAK4 and MAP3K7. Interacts with BCL10; this interaction is impaired by SOCS3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for PELI2 Gene

neXtProt entry for PELI2 Gene

Post-translational modifications for PELI2 Gene

  • Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity.
  • Ubiquitination at Lys 164 and Lys 268
  • Modification sites at PhosphoSitePlus

Other Protein References for PELI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PELI2 Gene

Domains & Families for PELI2 Gene

Gene Families for PELI2 Gene

Protein Domains for PELI2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PELI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAT8

UniProtKB/Swiss-Prot:

PELI2_HUMAN :
  • The atypical FHA domain contains a wing insert and mediates binding to threonine-phosphorylated IRAK1.
  • Belongs to the pellino family.
Domain:
  • The atypical FHA domain contains a wing insert and mediates binding to threonine-phosphorylated IRAK1.
  • Contains 1 FHA domain.
Family:
  • Belongs to the pellino family.
genes like me logo Genes that share domains with PELI2: view

Function for PELI2 Gene

Molecular function for PELI2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 Lys-63-linked polyubiquitination and possibly Lys-48-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Enzyme Numbers (IUBMB) for PELI2 Gene

Gene Ontology (GO) - Molecular Function for PELI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12860405
GO:0016874 ligase activity IEA --
GO:0034450 ubiquitin-ubiquitin ligase activity TAS --
genes like me logo Genes that share ontologies with PELI2: view
genes like me logo Genes that share phenotypes with PELI2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PELI2 Gene

Localization for PELI2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PELI2 Gene COMPARTMENTS Subcellular localization image for PELI2 gene
Compartment Confidence
cytosol 5
cytoskeleton 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PELI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PELI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PELI2 Gene

Pathways & Interactions for PELI2 Gene

genes like me logo Genes that share pathways with PELI2: view

UniProtKB/Swiss-Prot Q9HAT8-PELI2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for PELI2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PELI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 12804775
GO:0008063 Toll signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS --
GO:0043410 positive regulation of MAPK cascade IDA 12804775
genes like me logo Genes that share ontologies with PELI2: view

Drugs & Compounds for PELI2 Gene

No Compound Related Data Available

Transcripts for PELI2 Gene

Unigene Clusters for PELI2 Gene

Pellino E3 ubiquitin protein ligase family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PELI2 Gene

No ASD Table

Relevant External Links for PELI2 Gene

GeneLoc Exon Structure for
PELI2
ECgene alternative splicing isoforms for
PELI2

Expression for PELI2 Gene

mRNA expression in normal human tissues for PELI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PELI2 Gene:

PELI2

SOURCE GeneReport for Unigene cluster for PELI2 Gene:

Hs.657926
genes like me logo Genes that share expression patterns with PELI2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PELI2 Gene

Orthologs for PELI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PELI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PELI2 34
  • 90.71 (n)
  • 98.81 (a)
PELI2 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Peli2 34
  • 87.03 (n)
  • 95.47 (a)
Peli2 16
Peli2 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PELI2 34
  • 99.6 (n)
  • 99.76 (a)
PELI2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Peli2 34
  • 86.87 (n)
  • 96.18 (a)
dog
(Canis familiaris)
Mammalia PELI2 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PELI2 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PELI2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PELI2 34
  • 82.05 (n)
  • 95.34 (a)
PELI2 35
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PELI2 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75650 34
peli1 34
  • 77.72 (n)
  • 91.65 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12828 34
peli2 34
  • 73.17 (n)
  • 85.95 (a)
peli2 35
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pli 36
  • 60 (a)
Pli 34
  • 61.35 (n)
  • 61.6 (a)
Pli 35
  • 58 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004232 34
  • 61.82 (n)
  • 62.32 (a)
worm
(Caenorhabditis elegans)
Secernentea F25B4.2 36
  • 42 (a)
CELE_F25B4.2 34
  • 50.29 (n)
  • 45.84 (a)
F25B4.2 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToMany
Species where no ortholog for PELI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PELI2 Gene

ENSEMBL:
Gene Tree for PELI2 (if available)
TreeFam:
Gene Tree for PELI2 (if available)

Paralogs for PELI2 Gene

Paralogs for PELI2 Gene

(2) SIMAP similar genes for PELI2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PELI2: view

Variants for PELI2 Gene

Sequence variations from dbSNP and Humsavar for PELI2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1471496 -- 56,221,594(-) TTGGC(C/T)TAGTC intron-variant
rs1471497 -- 56,221,467(-) TGAAA(C/T)AATTA intron-variant
rs1479741 -- 56,201,105(-) CAGGG(C/T)GCATG intron-variant
rs1479742 -- 56,200,953(-) AAAAA(A/G)AAGGC intron-variant
rs1479743 -- 56,200,886(-) ACTAA(C/T)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PELI2 Gene

Variant ID Type Subtype PubMed ID
dgv1267e59 CNV tandem duplication 20981092
esv1586377 CNV insertion 17803354
esv2676142 CNV deletion 23128226
esv3305519 CNV mobile element insertion 20981092
esv3345549 CNV duplication 20981092
esv3581210 CNV loss 25503493
esv989258 CNV insertion 20482838
nsv1142848 CNV tandem duplication 24896259
nsv1143751 CNV deletion 24896259
nsv479046 CNV novel sequence insertion 20440878
nsv519617 CNV gain 19592680

Variation tolerance for PELI2 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PELI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PELI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PELI2 Gene

Disorders for PELI2 Gene

Relevant External Links for PELI2

Genetic Association Database (GAD)
PELI2
Human Genome Epidemiology (HuGE) Navigator
PELI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PELI2

No disorders were found for PELI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PELI2 Gene

Publications for PELI2 Gene

  1. Characterization of Pellino2, a substrate of IRAK1 and IRAK4. (PMID: 12860405) Strelow A. … Wesche H. (FEBS Lett. 2003) 2 3 4 65
  2. Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. (PMID: 11306823) Resch K. … Schmitt-John T. (Cytogenet. Cell Genet. 2001) 2 3 4 65
  3. Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control. (PMID: 22669975) Kim T.W. … Li X. (J. Biol. Chem. 2012) 3 4 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. (PMID: 17997719) Ordureau A. … Cohen P. (Biochem. J. 2008) 3 4 65

Products for PELI2 Gene

Sources for PELI2 Gene

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