Aliases for PELI2 Gene
External Ids for PELI2 Gene
Previous GeneCards Identifiers for PELI2 Gene
GeneCards Summary for PELI2 Gene
PELI2 (Pellino E3 Ubiquitin Protein Ligase Family Member 2) is a Protein Coding gene. Among its related pathways are MyD88 cascade initiated on plasma membrane and IRAK1 recruits IKK complex. GO annotations related to this gene include ligase activity. An important paralog of this gene is PELI1.
UniProtKB/Swiss-Prot for PELI2 Gene
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 Lys-63-linked polyubiquitination and possibly Lys-48-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.