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Aliases for PELI1 Gene

Aliases for PELI1 Gene

  • Pellino E3 Ubiquitin Protein Ligase 1 2 3
  • Pellino-Related Intracellular-Signaling Molecule 3 4
  • Pellino-1 3 4
  • E3 Ubiquitin-Protein Ligase Pellino Homolog 1 3
  • Pellino (Drosophila) Homolog 1 2
  • Pellino Homolog 1 (Drosophila) 2
  • Protein Pellino Homolog 1 3
  • Pellino Homolog 1 3
  • EC 6.3.2.- 4
  • PRISM 4

External Ids for PELI1 Gene

Previous GeneCards Identifiers for PELI1 Gene

  • GC02M064454
  • GC02M064277
  • GC02M064294
  • GC02M064231
  • GC02M064319
  • GC02M064059

Summaries for PELI1 Gene

GeneCards Summary for PELI1 Gene

PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Toll Like Receptor 7/8 (TLR7/8) Cascade. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is PELI3.

UniProtKB/Swiss-Prot for PELI1 Gene

  • E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates Lys-63-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.

Gene Wiki entry for PELI1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PELI1 Gene

Genomics for PELI1 Gene

Regulatory Elements for PELI1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PELI1 Gene

Start:
64,092,652 bp from pter
End:
64,144,471 bp from pter
Size:
51,820 bases
Orientation:
Minus strand

Genomic View for PELI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PELI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PELI1 Gene

Proteins for PELI1 Gene

  • Protein details for PELI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FA3-PELI1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase pellino homolog 1
    Protein Accession:
    Q96FA3
    Secondary Accessions:
    • Q96SM0
    • Q9GZY5
    • Q9HCX0

    Protein attributes for PELI1 Gene

    Size:
    418 amino acids
    Molecular mass:
    46286 Da
    Quaternary structure:
    • Interacts with MAP3K7. Upon IL1B treatment, forms a complex with TRAF6, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression.
    SequenceCaution:
    • Sequence=AAH11419.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55280.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PELI1 Gene

Proteomics data for PELI1 Gene at MOPED

Post-translational modifications for PELI1 Gene

Other Protein References for PELI1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PELI1 Gene

Domains for PELI1 Gene

Gene Families for PELI1 Gene

HGNC:
  • PELI :Pellino homologs

Protein Domains for PELI1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96FA3

UniProtKB/Swiss-Prot:

PELI1_HUMAN :
  • Q96FA3
Family:
  • Belongs to the pellino family.
genes like me logo Genes that share domains with PELI1: view

Function for PELI1 Gene

Molecular function for PELI1 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates Lys-63-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.

Enzyme Numbers (IUBMB) for PELI1 Gene

Gene Ontology (GO) - Molecular Function for PELI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 12496252
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with PELI1: view
genes like me logo Genes that share phenotypes with PELI1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PELI1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PELI1 Gene

Localization for PELI1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PELI1 Gene COMPARTMENTS Subcellular localization image for PELI1 gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PELI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PELI1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PELI1 Gene

Pathways for PELI1 Gene

genes like me logo Genes that share pathways with PELI1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q96FA3-PELI1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for PELI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination --
GO:0001819 positive regulation of cytokine production IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0008063 Toll signaling pathway IEA --
genes like me logo Genes that share ontologies with PELI1: view

Transcripts for PELI1 Gene

Unigene Clusters for PELI1 Gene

Pellino E3 ubiquitin protein ligase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PELI1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PELI1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - - - -
SP8:

Relevant External Links for PELI1 Gene

GeneLoc Exon Structure for
PELI1
ECgene alternative splicing isoforms for
PELI1

Expression for PELI1 Gene

mRNA expression in normal human tissues for PELI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PELI1 Gene

This gene is overexpressed in Whole Blood (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PELI1 Gene

SOURCE GeneReport for Unigene cluster for PELI1 Gene Hs.7886

genes like me logo Genes that share expressions with PELI1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PELI1 Gene

Orthologs for PELI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PELI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PELI1 35
  • 99.44 (n)
  • 99.52 (a)
PELI1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PELI1 35
  • 94.74 (n)
  • 99.52 (a)
PELI1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PELI1 35
  • 95.93 (n)
  • 99.76 (a)
PELI1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Peli1 35
  • 92.9 (n)
  • 99.76 (a)
Peli1 16
Peli1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PELI1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PELI1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Peli1 35
  • 91.39 (n)
  • 99.76 (a)
chicken
(Gallus gallus)
Aves PELI1 35
  • 83.62 (n)
  • 99.26 (a)
PELI1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PELI1 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia peli1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia peli2 35
  • 82.62 (n)
  • 97.13 (a)
zebrafish
(Danio rerio)
Actinopterygii peli1a 36
  • 69 (a)
OneToMany
peli1b 35
  • 74.16 (n)
  • 90.67 (a)
peli1b 36
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pli 36
  • 58 (a)
OneToMany
Pli 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea F25B4.2 36
  • 39 (a)
OneToMany
F25B4.2 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for PELI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PELI1 Gene

ENSEMBL:
Gene Tree for PELI1 (if available)
TreeFam:
Gene Tree for PELI1 (if available)

Paralogs for PELI1 Gene

Paralogs for PELI1 Gene

Selected SIMAP similar genes for PELI1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PELI1: view

Variants for PELI1 Gene

Sequence variations from dbSNP and Humsavar for PELI1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs189067 -- 64,104,285(-) ACATT(G/T)GGATG intron-variant
rs191298 -- 64,104,348(-) AGGGG(C/T)CTCCC intron-variant
rs329481 -- 64,107,745(+) CGATC(C/T)CAGCT intron-variant
rs329482 -- 64,110,016(+) gaggc(A/G)ggaag intron-variant
rs329497 -- 64,100,458(-) ACTTT(A/G)TCTCG reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PELI1 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
dgv1191e1 CNV Complex 17122850
nsv428396 CNV Gain 18775914
dgv151e55 CNV Gain 17911159
nsv834243 CNV Gain+Loss 17160897
nsv9957 CNV Gain 18304495
esv259937 OTHER Complex 20981092
esv29437 CNV Gain 19812545
dgv1192e1 CNV Complex 17122850

Relevant External Links for PELI1 Gene

HapMap Linkage Disequilibrium report
PELI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PELI1 Gene

Disorders for PELI1 Gene

Relevant External Links for PELI1

Genetic Association Database (GAD)
PELI1
Human Genome Epidemiology (HuGE) Navigator
PELI1
genes like me logo Genes that share disorders with PELI1: view

No data available for UniProtKB/Swiss-Prot for PELI1 Gene

Publications for PELI1 Gene

  1. Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. (PMID: 11306823) Resch K. … Schmitt-John T. (Cytogenet. Cell Genet. 2001) 2 3 4 23
  2. Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. (PMID: 12496252) Jiang Z. … Li X. (J. Biol. Chem. 2003) 3 4 23
  3. Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. (PMID: 17675297) Butler M.P. … Moynagh P.N. (J. Biol. Chem. 2007) 3 4 23
  4. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. (PMID: 17997719) Ordureau A. … Cohen P. (Biochem. J. 2008) 3 4 23
  5. Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. (PMID: 16951688) Choi K.C. … Park S.H. (Nat. Immunol. 2006) 2 3 4

Products for PELI1 Gene

Sources for PELI1 Gene

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