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Aliases for PELI1 Gene

Aliases for PELI1 Gene

  • Pellino E3 Ubiquitin Protein Ligase 1 2 3 5
  • Pellino-Related Intracellular-Signaling Molecule 3 4
  • Pellino-1 3 4
  • Pellino (Drosophila) Homolog 1 2
  • Pellino Homolog 1 (Drosophila) 2
  • Protein Pellino Homolog 1 3
  • Pellino Homolog 1 3
  • EC 6.3.2.- 4
  • PRISM 4

External Ids for PELI1 Gene

Previous GeneCards Identifiers for PELI1 Gene

  • GC02M064454
  • GC02M064277
  • GC02M064294
  • GC02M064231
  • GC02M064319
  • GC02M064059

Summaries for PELI1 Gene

GeneCards Summary for PELI1 Gene

PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling and MyD88 cascade initiated on plasma membrane. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PELI3.

UniProtKB/Swiss-Prot for PELI1 Gene

  • E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates Lys-63-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.

Gene Wiki entry for PELI1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PELI1 Gene

Genomics for PELI1 Gene

Regulatory Elements for PELI1 Gene

Enhancers for PELI1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PELI1 on UCSC Golden Path with GeneCards custom track

Promoters for PELI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PELI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PELI1 Gene

Chromosome:
2
Start:
64,092,652 bp from pter
End:
64,144,471 bp from pter
Size:
51,820 bases
Orientation:
Minus strand

Genomic View for PELI1 Gene

Genes around PELI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PELI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PELI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PELI1 Gene

Proteins for PELI1 Gene

  • Protein details for PELI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FA3-PELI1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase pellino homolog 1
    Protein Accession:
    Q96FA3
    Secondary Accessions:
    • Q96SM0
    • Q9GZY5
    • Q9HCX0

    Protein attributes for PELI1 Gene

    Size:
    418 amino acids
    Molecular mass:
    46286 Da
    Quaternary structure:
    • Interacts with MAP3K7. Upon IL1B treatment, forms a complex with TRAF6, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression.
    SequenceCaution:
    • Sequence=AAH11419.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55280.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PELI1 Gene

Proteomics data for PELI1 Gene at MOPED

Post-translational modifications for PELI1 Gene

Other Protein References for PELI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PELI1 (PELI1)

No data available for DME Specific Peptides for PELI1 Gene

Domains & Families for PELI1 Gene

Gene Families for PELI1 Gene

Protein Domains for PELI1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96FA3

UniProtKB/Swiss-Prot:

PELI1_HUMAN :
  • Belongs to the pellino family.
Family:
  • Belongs to the pellino family.
genes like me logo Genes that share domains with PELI1: view

Function for PELI1 Gene

Molecular function for PELI1 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates Lys-63-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.

Enzyme Numbers (IUBMB) for PELI1 Gene

Gene Ontology (GO) - Molecular Function for PELI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with PELI1: view
genes like me logo Genes that share phenotypes with PELI1: view

Animal Models for PELI1 Gene

MGI Knock Outs for PELI1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PELI1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PELI1 Gene

Localization for PELI1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PELI1 Gene COMPARTMENTS Subcellular localization image for PELI1 gene
Compartment Confidence
cytosol 5
nucleus 3
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PELI1 Gene

Pathways & Interactions for PELI1 Gene

genes like me logo Genes that share pathways with PELI1: view

Pathways by source for PELI1 Gene

1 Cell Signaling Technology pathway for PELI1 Gene

UniProtKB/Swiss-Prot Q96FA3-PELI1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for PELI1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PELI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0008063 Toll signaling pathway IEA --
GO:0031398 positive regulation of protein ubiquitination IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IEA --
genes like me logo Genes that share ontologies with PELI1: view

Drugs & Compounds for PELI1 Gene

No Compound Related Data Available

Transcripts for PELI1 Gene

Unigene Clusters for PELI1 Gene

Pellino E3 ubiquitin protein ligase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PELI1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - - - -
SP8:

Relevant External Links for PELI1 Gene

GeneLoc Exon Structure for
PELI1
ECgene alternative splicing isoforms for
PELI1

Expression for PELI1 Gene

mRNA expression in normal human tissues for PELI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PELI1 Gene

This gene is overexpressed in Whole Blood (x5.8).

Protein differential expression in normal tissues from HIPED for PELI1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PELI1 Gene



SOURCE GeneReport for Unigene cluster for PELI1 Gene Hs.7886

genes like me logo Genes that share expression patterns with PELI1: view

Protein tissue co-expression partners for PELI1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PELI1 Gene

Orthologs for PELI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PELI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PELI1 35
  • 94.74 (n)
  • 99.52 (a)
PELI1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PELI1 35
  • 95.93 (n)
  • 99.76 (a)
PELI1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Peli1 35
  • 92.9 (n)
  • 99.76 (a)
Peli1 16
Peli1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PELI1 35
  • 99.44 (n)
  • 99.52 (a)
PELI1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Peli1 35
  • 91.39 (n)
  • 99.76 (a)
oppossum
(Monodelphis domestica)
Mammalia PELI1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PELI1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves PELI1 35
  • 83.62 (n)
  • 99.26 (a)
PELI1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PELI1 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia peli2 35
  • 82.62 (n)
  • 97.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia peli1-prov 35
zebrafish
(Danio rerio)
Actinopterygii peli1b 35
  • 74.16 (n)
  • 90.67 (a)
peli1a 36
  • 69 (a)
OneToMany
peli1b 36
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pli 37
  • 60 (a)
Pli 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F25B4.2 37
  • 43 (a)
F25B4.2 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for PELI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PELI1 Gene

ENSEMBL:
Gene Tree for PELI1 (if available)
TreeFam:
Gene Tree for PELI1 (if available)

Paralogs for PELI1 Gene

Paralogs for PELI1 Gene

(2) SIMAP similar genes for PELI1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PELI1: view

Variants for PELI1 Gene

Sequence variations from dbSNP and Humsavar for PELI1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs714672 -- 64,119,188(+) TAACT(C/T)CTTCC intron-variant
rs717382 -- 64,120,001(-) GGATA(A/G)TATAG intron-variant
rs1814406 -- 64,117,937(-) AGCTA(C/G)TTAGG intron-variant
rs1837484 -- 64,110,607(+) cttct(A/G)aattt intron-variant
rs2901645 -- 64,112,773(+) TCAAT(A/G)TACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PELI1 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
dgv1191e1 CNV Complex 17122850
nsv428396 CNV Gain 18775914
dgv151e55 CNV Gain 17911159
nsv834243 CNV Gain+Loss 17160897
nsv9957 CNV Gain 18304495
esv259937 OTHER Complex 20981092
esv29437 CNV Gain 19812545
dgv1192e1 CNV Complex 17122850

Variation tolerance for PELI1 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PELI1 Gene

HapMap Linkage Disequilibrium report
PELI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PELI1 Gene

Disorders for PELI1 Gene

Relevant External Links for PELI1

Genetic Association Database (GAD)
PELI1
Human Genome Epidemiology (HuGE) Navigator
PELI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PELI1

No disorders were found for PELI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PELI1 Gene

Publications for PELI1 Gene

  1. Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. (PMID: 11306823) Resch K. … Schmitt-John T. (Cytogenet. Cell Genet. 2001) 2 3 4 23 67
  2. Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4. (PMID: 19264966) Smith H. … Cohen P. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. (PMID: 17997719) Ordureau A. … Cohen P. (Biochem. J. 2008) 3 23
  4. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. (PMID: 19081057) Lin C.C. … Ferguson K.M. (Structure 2008) 3 23
  5. Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. (PMID: 17675297) Butler M.P. … Moynagh P.N. (J. Biol. Chem. 2007) 3 23

Products for PELI1 Gene

Sources for PELI1 Gene

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