Aliases for PELI1 Gene
External Ids for PELI1 Gene
Previous GeneCards Identifiers for PELI1 Gene
GeneCards Summary for PELI1 Gene
PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are MyD88 cascade initiated on plasma membrane and IRAK1 recruits IKK complex. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PELI2.
UniProtKB/Swiss-Prot for PELI1 Gene
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates Lys-63-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.