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PELI1 Gene

protein-coding   GIFtS: 58
GCID: GC02M064319

Pellino E3 Ubiquitin Protein Ligase 1

(Previous names: pellino (Drosophila) homolog 1, pellino homolog 1 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pellino E3 Ubiquitin Protein Ligase 11 2     pellino-12
Pellino-Related Intracellular-Signaling Molecule2 3     Protein Pellino Homolog 12
Pellino (Drosophila) Homolog 11     EC 6.3.2.-3
Pellino Homolog 1 (Drosophila)1     PRISM3
E3 Ubiquitin-Protein Ligase Pellino Homolog 12     Pellino-13
Pellino Homolog 12     

External Ids:    HGNC: 88271   Entrez Gene: 571622   Ensembl: ENSG000001973297   OMIM: 6147975   UniProtKB: Q96FA33   

Export aliases for PELI1 gene to outside databases

Previous GC identifers: GC02M064454 GC02M064277 GC02M064294 GC02M064231 GC02M064059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PELI1 Gene:
PELI1 (pellino E3 ubiquitin protein ligase 1) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is PELI2.

UniProtKB/Swiss-Prot: PELI1_HUMAN, Q96FA3
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and
TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation

Gene Wiki entry for PELI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PELI1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   Cdc5   C/EBPalpha   Egr-4   SRY   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPELI1 promoter sequence
   Search Chromatin IP Primers for PELI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PELI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p13.3

PELI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PELI1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M064319:  view genomic region     (about GC identifiers)

Start:
64,319,786 bp from pter      End:
64,371,605 bp from pter
Size:
51,820 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PELI1_HUMAN, Q96FA3 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase pellino homolog 1  
Size: 418 amino acids; 46286 Da
Subunit: Interacts with MAP3K7. Upon IL1B treatment, forms a complex with TRAF6, IRAK1, IRAK4 and MYD88; this
complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1
prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually
NF-kappa-B-mediated gene expression
Sequence caution: Sequence=AAH11419.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB55280.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96SM0 Q9GZY5 Q9HCX0

Explore the universe of human proteins at neXtProt for PELI1: NX_Q96FA3

Explore proteomics data for PELI1 at MOPED

Post-translational modifications: 

  • Phosphorylation by IRAK1 and IRAK4 enhances its E3 ligase activity1
  • Sumoylated1
  • Ubiquitination2 at Lys266
  • Modification sites at PhosphoSitePlus

  • See PELI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065702.2  
    ENSEMBL proteins: 
     ENSP00000351789  
    Reactome Protein details: Q96FA3

    PELI1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PELI1

     
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    PELI1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for PELI1

    PELI1 Assay Products:

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    Cloud-Clone Corp. ELISAs for PELI1
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    Search eBioscience for ELISAs for PELI1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PELI: Pellino homologs

    1 InterPro protein domain:
     IPR006800 Pellino_fam

    Graphical View of Domain Structure for InterPro Entry Q96FA3

    ProtoNet protein and cluster: Q96FA3

    UniProtKB/Swiss-Prot: PELI1_HUMAN, Q96FA3
    Similarity: Belongs to the pellino family


    Find genes that share domains with PELI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PELI1_HUMAN, Q96FA3
    Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
    Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and
    TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI12496252
         
    Find genes that share ontologies with PELI1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Peli1):
     cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging 

    Find genes that share phenotypes with PELI1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PELI1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PELI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PELI1

    miRNA
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    miRTarBase miRNAs that target PELI1:
    hsa-mir-106a-5p (MIRT048318), hsa-mir-374b-5p (MIRT016081), hsa-mir-155-5p (MIRT005096), hsa-mir-21-5p (MIRT031077), hsa-mir-340-5p (MIRT019644), hsa-mir-17-5p (MIRT050853), hsa-mir-296-3p (MIRT038510)

    Block miRNA regulation of human, mouse, rat PELI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PELI1 (see all 27):
    hsa-miR-30c hsa-miR-3910 hsa-miR-448 hsa-miR-3607-3p hsa-miR-374a hsa-miR-301a hsa-miR-30d hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmidPELI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PELI1
    Predesigned siRNA for gene silencing in human, mouse, rat PELI1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PELI1

    Clone
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    OriGene clones in human, mouse for PELI1 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PELI1 (NM_020651)
    Sino Biological Human cDNA Clone for PELI1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PELI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PELI1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PELI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with PELI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PELI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88 dependent cascade initiated on endosome0.69
    2IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
    IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
    IRAK1 recruits IKK complex0.00
    3Interferon Signaling
    Cytokine Signaling in Immune system0.59
    4Interleukin-1 signaling
    Interleukin-1 signaling0.45
    5Signaling by Interleukins
    Signaling by Interleukins0.42


    Find genes that share SuperPaths with PELI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for PELI1
        Interleukin-1 signaling
    IRAK1 recruits IKK complex
    IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


    UniProtKB/Swiss-Prot: PELI1_HUMAN, Q96FA3
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PELI1: 

              Toll-Like Receptor Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PELI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PELI1 (Q96FA31, 2, 3 ENSP000003517894) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1P516171, 2, 3, ENSP000003589974EBI-448369,EBI-358664 MINT-2845005 I2D: score=6 STRING: ENSP00000358997
    IRAK2O431873, ENSP000002564584I2D: score=2 STRING: ENSP00000256458
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MYD88Q998363, ENSP000003796254I2D: score=1 STRING: ENSP00000379625
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination ----
    GO:0001819positive regulation of cytokine production IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0008063Toll signaling pathway IEA--

    Find genes that share ontologies with PELI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PELI1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PELI1 gene: 
    NM_020651.3  

    Unigene Cluster for PELI1:

    Pellino E3 ubiquitin protein ligase 1
    Hs.7886  [show with all ESTs]
    Unigene Representative Sequence: AF302505
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358912(uc002scr.4 uc002scs.4 uc002sct.4) ENST00000466177
    ENST00000494203 ENST00000468869
    miRNA
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    Block miRNA regulation of human, mouse, rat PELI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PELI1 (see all 27):
    hsa-miR-30c hsa-miR-3910 hsa-miR-448 hsa-miR-3607-3p hsa-miR-374a hsa-miR-301a hsa-miR-30d hsa-miR-548g
    SwitchGear 3'UTR luciferase reporter plasmidPELI1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PELI1 (NM_020651)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PELI1
    Primer
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    OriGene qPCR primer pairs and template standards for PELI1
    OriGene qSTAR qPCR primer pairs in human, mouse for PELI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PELI1
      QuantiTect SYBR Green Assays in human, mouse, rat PELI1
      QuantiFast Probe-based Assays in human, mouse, rat PELI1

    Additional mRNA sequence: 

    AF086327.1 AF300987.1 AF302505.1 AJ278859.1 AK022261.1 AK026714.1 AK027668.1 AK312441.1 
    AY364257.1 BC011419.1 BC050019.1 BC050533.1 BC063611.1 BX649152.1 

    8 DOTS entries:

    DT.101979601  DT.115900  DT.421586  DT.40194907  DT.100765232  DT.100659585  DT.95279257  DT.95279258 

    Selected AceView cDNA sequences (see all 203):

    AW770838 AA713603 AA320372 AI242272 F01839 BM992606 AK022261 AA731662 
    BE466752 AA713601 AW293650 BP430927 BU686702 BC011419 BQ029889 BQ897912 
    BF591591 AJ278859 BC050019 CB215807 BM791468 AI867442 W73187 AA649012 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PELI1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                          -                 -           -                                       
    SP2:                          -                 -     -     -                                       
    SP3:                          -     -     -     -     -     -                                       
    SP4:                          -                 -                                                   
    SP5:                          -           -     -           -                                       


    ECgene alternative splicing isoforms for PELI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PELI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGTGACT
    PELI1 Expression
    About this image


    PELI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    PELI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PELI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7886
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PELI1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PELI1
    OriGene qSTAR qPCR primer pairs in human, mouse for PELI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PELI1
    QuantiTect SYBR Green Assays in human, mouse, rat PELI1
    QuantiFast Probe-based Assays in human, mouse, rat PELI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PELI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PELI1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Peli11 , 5 pellino 11, 5 92.9(n)1
    99.76(a)1
      11 (13.81 cM)5
    672451  NM_023324.21  NP_075813.21 
     210912915 
    chicken
    (Gallus gallus)
    Aves PELI11 pellino homolog 1 (Drosophila) 83.62(n)
    99.26(a)
      421279  NM_001012872.2  NP_001012890.1 
    lizard
    (Anolis carolinensis)
    Reptilia PELI16
    pellino E3 ubiquitin protein ligase 1
    98(a)
    1 ↔ 1
    1(120369332-120435393)
    African clawed frog
    (Xenopus laevis)
    Amphibia peli1-prov2 pellino homolog 1 (Drosophila) 81.69(n)    BC044117.1 
    zebrafish
    (Danio rerio)
    Actinopterygii peli1b1 pellino homolog 1b (Drosophila) 74.16(n)
    90.67(a)
      558420  NM_001077601.2  NP_001071069.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pli3 defense response 60(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F25B4.23   -- 43(a)   V(5712017-5715093)   --


    ENSEMBL Gene Tree for PELI1 (if available)
    TreeFam Gene Tree for PELI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PELI1 gene
    PELI22  PELI32  
    2 SIMAP similar genes for PELI1 using alignment to 2 protein entries:     PELI1_HUMAN (see all proteins):
    PELI2    PELI3

    Find genes that share paralogs with PELI1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PELI1 (see all 1009)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829655121,2
    --64319314(+) TCATTA/TCCCTA 1 -- int10--------
    rs1875507541,2
    --64319362(+) ATTAAG/TTAGCA 1 -- int10--------
    rs1391568431,2
    --64319396(+) TAAAAA/GAGTTA 1 -- int10--------
    rs1451051391,2
    --64319456(+) AACTTC/TTTCTC 1 -- int10--------
    rs1471609171,2
    C--64319476(+) CAGAAC/TACTGA 1 -- int10--------
    rs1404371151,2
    --64319478(+) GAATAC/GTGACA 1 -- int10--------
    rs1485878551,2
    C--64319527(+) ATGAC-/AAAAAT 1 -- int10--------
    rs1441944361,2
    --64319650(+) TTTTAA/CCTGTT 1 -- int10--------
    rs1454849651,2
    C--64319696(+) AACTTC/TTATGG 1 -- int10--------
    rs1489962821,2
    --64319737(+) TGCAAC/TTTACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PELI1 (64319786 - 64371605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PELI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428396CNV Gain18775914
    esv29437CNV Gain19812545
    nsv9957CNV Gain18304495
    dgv151e55CNV Gain17911159
    nsv834243CNV Gain+Loss17160897
    dgv1191e1CNV Complex17122850
    dgv1192e1CNV Complex17122850
    nsv7313OTHER Inversion18451855
    esv259937OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PELI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614797    OMIM disorders: --


    Find genes that share disorders with PELI1           About GenesLikeMe

    Genetic Association Database (GAD): PELI1
    Human Genome Epidemiology (HuGE) Navigator: PELI1 (1 document)

    Export disorders for PELI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PELI1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with PELI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. (PubMed id 11306823)1, 2, 3, 9 Resch K.... Schmitt-John T. (Cytogenet. Cell Genet. 2001)
    2. Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. (PubMed id 16951688)1, 2, 3 Choi K.C.... Park S.H. (Nat. Immunol. 2006)
    3. Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. (PubMed id 17675297)1, 2, 9 Butler M.P.... Moynagh P.N. (J. Biol. Chem. 2007)
    4. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. (PubMed id 17997719)1, 2, 9 Ordureau A....Cohen P. (Biochem. J. 2008)
    5. Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. (PubMed id 12496252)1, 2, 9 Jiang Z.... Li X. (J. Biol. Chem. 2003)
    6. A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease. (PubMed id 21221998)1, 4 Kim J.J....Lee J.K. (Hum. Genet. 2011)
    7. Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9. (PubMed id 21120624)1, 2 Kim J.H....Park S.H. (Mol. Cells 2011)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Pellino2 activates the mitogen activated protein kinase pathway. (PubMed id 12804775)1, 2 Jensen L.E. and Whitehead A.S. (FEBS Lett. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57162 HGNC: 8827 AceView: PELI1 Ensembl:ENSG00000197329 euGenes: HUgn57162
    ECgene: PELI1 H-InvDB: PELI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PELI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PELI1 gene:
    Search GeneIP for patents involving PELI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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