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Aliases for PEG3 Gene

Aliases for PEG3 Gene

  • Paternally Expressed 3 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 24 3 4
  • ZSCAN24 3 4
  • Kruppel-Type Zinc Finger Protein 3
  • ZKSCAN22 3
  • KIAA0287 4
  • ZNF904 3
  • PW1 3

External Ids for PEG3 Gene

Previous GeneCards Identifiers for PEG3 Gene

  • GC19U990074
  • GC19M061977
  • GC19M061394
  • GC19M062015
  • GC19M057288
  • GC19M057321

Summaries for PEG3 Gene

Entrez Gene Summary for PEG3 Gene

  • In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]

GeneCards Summary for PEG3 Gene

PEG3 (Paternally Expressed 3) is a Protein Coding gene. Diseases associated with PEG3 include Glioma and Undifferentiated Embryonal Sarcoma Of The Liver. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for PEG3 Gene

  • Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.

Gene Wiki entry for PEG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PEG3 Gene

Genomics for PEG3 Gene

Regulatory Elements for PEG3 Gene

Enhancers for PEG3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PEG3 on UCSC Golden Path with GeneCards custom track

Promoters for PEG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PEG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PEG3 Gene

Chromosome:
19
Start:
56,810,077 bp from pter
End:
56,840,728 bp from pter
Size:
30,652 bases
Orientation:
Minus strand

Genomic View for PEG3 Gene

Genes around PEG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PEG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PEG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PEG3 Gene

Proteins for PEG3 Gene

  • Protein details for PEG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZU2-PEG3_HUMAN
    Recommended name:
    Paternally-expressed gene 3 protein
    Protein Accession:
    Q9GZU2
    Secondary Accessions:
    • A7E2B8
    • B4DIM4
    • C9JP50
    • P78418
    • Q5H9P9
    • Q7Z7H7
    • Q8TF75
    • Q9GZY2

    Protein attributes for PEG3 Gene

    Size:
    1588 amino acids
    Molecular mass:
    180827 Da
    Quaternary structure:
    • Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 (By similarity).
    SequenceCaution:
    • Sequence=BAB85588.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAI45975.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PEG3 Gene

    Alternative splice isoforms for PEG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PEG3 Gene

Proteomics data for PEG3 Gene at MOPED

Post-translational modifications for PEG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PEG3 Gene

Domains & Families for PEG3 Gene

Gene Families for PEG3 Gene

Suggested Antigen Peptide Sequences for PEG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZU2

UniProtKB/Swiss-Prot:

PEG3_HUMAN :
  • The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with PEG3: view

Function for PEG3 Gene

Molecular function for PEG3 Gene

GENATLAS Biochemistry:
zinc finger protein,Kruppel type (C2H2) predominantly expressed in ovary,testis,placenta,murine paternally expressed gene 3
UniProtKB/Swiss-Prot Function:
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.

Gene Ontology (GO) - Molecular Function for PEG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with PEG3: view
genes like me logo Genes that share phenotypes with PEG3: view

Animal Models for PEG3 Gene

MGI Knock Outs for PEG3:

Animal Model Products

miRNA for PEG3 Gene

miRTarBase miRNAs that target PEG3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PEG3 Gene

Localization for PEG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PEG3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PEG3 Gene COMPARTMENTS Subcellular localization image for PEG3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PEG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PEG3: view

Pathways & Interactions for PEG3 Gene

genes like me logo Genes that share pathways with PEG3: view

Pathways by source for PEG3 Gene

1 BioSystems pathway for PEG3 Gene

Gene Ontology (GO) - Biological Process for PEG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006915 apoptotic process IEA --
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with PEG3: view

No data available for SIGNOR curated interactions for PEG3 Gene

Drugs & Compounds for PEG3 Gene

(1) Drugs for PEG3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for PEG3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PEG3: view

Transcripts for PEG3 Gene

Unigene Clusters for PEG3 Gene

Paternally expressed 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PEG3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
SP1: - - - - - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6:
SP7: -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - -
SP13:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PEG3 Gene

GeneLoc Exon Structure for
PEG3
ECgene alternative splicing isoforms for
PEG3

Expression for PEG3 Gene

mRNA expression in normal human tissues for PEG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PEG3 Gene

This gene is overexpressed in Ovary (x7.2) and Brain - Hypothalamus (x6.0).

Protein differential expression in normal tissues from HIPED for PEG3 Gene

This gene is overexpressed in Testis (41.9) and Fetal ovary (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PEG3 Gene



SOURCE GeneReport for Unigene cluster for PEG3 Gene Hs.731875

mRNA Expression by UniProt/SwissProt for PEG3 Gene

Q9GZU2-PEG3_HUMAN
Tissue specificity: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.
genes like me logo Genes that share expression patterns with PEG3: view

Protein tissue co-expression partners for PEG3 Gene

- Elite partner

Primer Products

Orthologs for PEG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PEG3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC476371 35
  • 81.65 (n)
  • 75.19 (a)
PEG3 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Peg3 35
  • 67.84 (n)
  • 59.06 (a)
Peg3 16
Peg3 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PEG3 35
  • 99.43 (n)
  • 98.99 (a)
PEG3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 24 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
OneToMany
-- 36
  • 17 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-266d19.4 36
  • 18 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Oaz 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
Species with no ortholog for PEG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PEG3 Gene

ENSEMBL:
Gene Tree for PEG3 (if available)
TreeFam:
Gene Tree for PEG3 (if available)

Paralogs for PEG3 Gene

genes like me logo Genes that share paralogs with PEG3: view

No data available for Paralogs for PEG3 Gene

Variants for PEG3 Gene

Sequence variations from dbSNP and Humsavar for PEG3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_027397 -
VAR_027398 -
VAR_027399 -
VAR_027400 -
VAR_035562 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for PEG3 Gene

Variant ID Type Subtype PubMed ID
nsv833884 CNV Loss 17160897

Variation tolerance for PEG3 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PEG3 Gene

Disorders for PEG3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PEG3 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glioma
undifferentiated embryonal sarcoma of the liver
  • embryonal sarcoma of the liver
embryonal sarcoma
  • undifferentiated sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search PEG3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PEG3

Genetic Association Database (GAD)
PEG3
Human Genome Epidemiology (HuGE) Navigator
PEG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PEG3
genes like me logo Genes that share disorders with PEG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PEG3 Gene

Publications for PEG3 Gene

  1. The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. (PMID: 9149948) Kim J. … Stubbs L. (Genome Res. 1997) 2 3 4 23 67
  2. The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. (PMID: 20064927) Jiang X. … Johnson M.D. (J. Biol. Chem. 2010) 3 23
  3. Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma. (PMID: 19367087) Otsuka S. … Nanba E. (Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 2009) 3 23
  4. DNA methylation analysis of the mammalian PEG3 imprinted domain. (PMID: 19397955) Huang J.M. … Kim J. (Gene 2009) 3 23
  5. Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. (PMID: 18286529) Feng W. … Bast R.C. (Cancer 2008) 3 23

Products for PEG3 Gene

Sources for PEG3 Gene

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