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PEG3 Gene

protein-coding   GIFtS: 58
GCID: GC19M057321

Paternally Expressed 3

  See PEG3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Paternally Expressed 31 2     ZNF9042
Zinc Finger And SCAN Domain-Containing Protein 242 3     Kruppel-Type Zinc Finger Protein2
ZSCAN242 3     Paternally-Expressed Gene 3 Protein2
PW12     KIAA02873
ZKSCAN222     

External Ids:    HGNC: 88261   Entrez Gene: 51782   Ensembl: ENSG000001983007   OMIM: 6014835   UniProtKB: Q9GZU23   
ORGUL members:         

Export aliases for PEG3 gene to outside databases

Previous GC identifers: GC19U990074 GC19M061977 GC19M061394 GC19M062015 GC19M057288


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PEG3 Gene:
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common
promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their
shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3.
In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as
well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger
protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor
suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results
in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Sep 2009)

GeneCards Summary for PEG3 Gene:
PEG3 (paternally expressed 3) is a protein-coding gene. Diseases associated with PEG3 include undifferentiated embryonal sarcoma of the liver, and embryonal sarcoma. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and nucleic acid binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2
Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal
death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis
through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells

Gene Wiki entry for PEG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PEG3 gene promoter:
         CREB   AML1a   FOXF2   Sp1   deltaCREB   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PEG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PEG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.4

PEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEG3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M057321:  view genomic region     (about GC identifiers)

Start:
57,321,445 bp from pter      End:
57,352,096 bp from pter
Size:
30,652 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2 (See protein sequence)
Recommended Name: Paternally-expressed gene 3 protein  
Size: 1588 amino acids; 180827 Da
Subunit: Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 (By similarity)
Sequence caution: Sequence=BAB85588.1; Type=Frameshift; Positions=Several; Sequence=CAI45975.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for PEG3:
4BHX (3D)    
Secondary accessions: A7E2B8 B4DIM4 C9JP50 P78418 Q5H9P9 Q7Z7H7 Q8TF75 Q9GZY2
Alternative splicing: 4 isoforms:  Q9GZU2-1   Q9GZU2-2   Q9GZU2-3   Q9GZU2-4   

Explore the universe of human proteins at neXtProt for PEG3: NX_Q9GZU2

Explore proteomics data for PEG3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PEG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001139656.1  NP_001139657.1  NP_001139658.1  NP_001139659.1  NP_006201.1  

    ENSEMBL proteins: 
     ENSP00000326581   ENSP00000473190   ENSP00000472402   ENSP00000472395   ENSP00000469486  
     ENSP00000470467   ENSP00000469144   ENSP00000403051  

    PEG3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PEG3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PEG3
    GenScript Custom Purified and Recombinant Proteins Services for PEG3
    Novus Biologicals PEG3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PEG3

     
    Search eBioscience for Proteins for PEG3 

    PEG3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PEG3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PEG3
    OriGene Custom Antibody Services for PEG3
    Search for Antibodies for PEG3 at Abcam
    Cloud-Clone Corp. Antibodies for PEG3
    Search ThermoFisher Antibodies for PEG3
    LSBio Antibodies in human, mouse, rat for PEG3

    PEG3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PEG3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PEG3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PEG3
    Cloud-Clone Corp. CLIAs for PEG3
    Search eBioscience for ELISAs for PEG3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9GZU2

    ProtoNet protein and cluster: Q9GZU2

    1 Blocks protein domain: IPB003309 Transcriptional regulator SCAN

    UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2
    Domain: The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial
    fashion
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    Find genes that share domains with PEG3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PEG3_HUMAN, Q9GZU2
    Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal
    death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis
    through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells

         Genatlas biochemistry entry for PEG3:
    zinc finger protein,Kruppel type (C2H2) predominantly expressed in ovary,testis,placenta,murine paternally
    expressed gene 3

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PEG3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PEG3:
     Decreased viability of wild-ty  Increased circadian period len 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Peg3):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  mortality/aging 
     nervous system 

    Find genes that share phenotypes with PEG3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Peg3tm1Masu for PEG3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PEG3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PEG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PEG3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PEG3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PEG3:
    hsa-mir-335-5p (MIRT018787)

    Block miRNA regulation of human, mouse, rat PEG3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PEG3 (see all 63):
    hsa-miR-21* hsa-miR-100* hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-1197 hsa-miR-200a hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PEG3
    Predesigned siRNA for gene silencing in human, mouse, rat PEG3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PEG3

    Clone
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    OriGene clones in human, mouse for PEG3 (see all 24)
    OriGene ORF clones in mouse, rat for PEG3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): PEG3 (NM_006210)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PEG3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PEG3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PEG3_HUMAN, Q9GZU2: Nucleus (By similarity). Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PEG3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PEG3 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for PEG3
        TNF-alpha/NF-kB Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PEG3
    Interactions:

        GeneGlobe Interaction Network for PEG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for PEG3 (Q9GZU22, 3 ENSP000003265814) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930092, 3, ENSP000003435354MINT-2861661 I2D: score=3 STRING: ENSP00000343535
    SIAH1Q8IUQ43, ENSP000003491564I2D: score=2 STRING: ENSP00000349156
    BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
    SIAH2O432553, ENSP000003224574I2D: score=2 STRING: ENSP00000322457
    TRAF2Q129333, ENSP000002476684I2D: score=1 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    Find genes that share ontologies with PEG3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PEG3

    4 Novoseek inferred chemical compound relationships for PEG3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peg-10 86.3 5 17701895 (2), 16778176 (2), 15057899 (1)
    5-aza-2'deoxycytidine 47.9 5 16023706 (1), 18286529 (1), 11398192 (1)
    zinc 35.1 6 8563758 (2), 9149948 (1), 11260267 (1), 11161803 (1) (see all 5)
    vegf 0 5 10611347 (3), 14753496 (2)



    Find genes that share compounds with PEG3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PEG3 gene (5 alternative transcripts): 
    NM_001146184.1  NM_001146185.1  NM_001146186.1  NM_001146187.1  NM_006210.2  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326441(uc002qnv.2) ENST00000599565 ENST00000598410 ENST00000593695
    ENST00000599534 ENST00000599577 ENST00000600833 ENST00000596261 ENST00000594706
    ENST00000594389 ENST00000423103(uc002qnt.2 uc002qnu.2 uc002qnw.2 uc002qnx.2 uc010etr.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PEG3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PEG3 (see all 63):
    hsa-miR-21* hsa-miR-100* hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-1197 hsa-miR-200a hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PEG3
    Predesigned siRNA for gene silencing in human, mouse, rat PEG3
    Clone
    Products:
         
    OriGene clones in human, mouse for PEG3 (see all 24)
    OriGene ORF clones in mouse, rat for PEG3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): PEG3 (NM_006210)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PEG3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PEG3
      QuantiTect SYBR Green Assays in human, mouse, rat PEG3
      QuantiFast Probe-based Assays in human, mouse, rat PEG3

    Selected AceView cDNA sequences (see all 273):

    BX491788 AI926648 AI963148 BG622420 AA084286 AF208967 AW086429 BQ023924 
    AF208969 NM_006210 AA449586 AF208968 AI143605 BE501949 AW590551 BE502379 
    AA033956 AV708395 CA950554 BE139174 AF166122 AA350686 BM723658 AA460030 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PEG3 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                          -     -     -     -     -     -     -                                               -     -     -           -                     
    SP2:                          -     -           -                                                                                                               
    SP3:                          -     -     -     -     -     -     -                                                                                             
    SP4:                          -     -     -     -                                                                                                               
    SP5:                          -     -     -     -     -     -     -                                                                                             

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for PEG3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PEG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCACCAT
    PEG3 Expression
    About this image


    PEG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Interstitial Stroma
             mK4
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Muscle Satellite Cells Lumbar Muscle Satellite Pool
             Extraocular Muscles
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
    PEG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PEG3 Protein Expression

    UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2
    Tissue specificity: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it
    is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian
    stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines

        Custom PCR Arrays for PEG3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PEG3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PEG3
    QuantiTect SYBR Green Assays in human, mouse, rat PEG3
    QuantiFast Probe-based Assays in human, mouse, rat PEG3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PEG3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Peg31 , 5 paternally expressed 31, 5 67.84(n)1
    59.06(a)1
      7 (3.89 cM)5
    186161  NM_008817.21  NP_032843.21 
     67038925 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    17(a)
    15(a)
    many → 1
    many → 1
    2(190206360-190219608)
    2(190172720-190199039)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ884395.12   -- 81.44(n)    BQ884395.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-266d19.46
    si:ch211-266d19.4
    18(a)
    many ↔ many
    24(2347319-2378426) ENSDARG00000012642
    fruit fly
    (Drosophila melanogaster)
    Insecta Oaz6
    O/E-associated zinc finger protein
    10(a)
    1 → many
    2R(10323404-10353386)


    ENSEMBL Gene Tree for PEG3 (if available)
    TreeFam Gene Tree for PEG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PEG3 gene
    ZNF912  ZNF5212  ZNF8502  ZNF7292  ZNF4232  ZNF2082  
    Selected SIMAP similar genes for PEG3 using alignment to 5 protein entries:     PEG3_HUMAN (see all proteins) (see all similar genes):
    KIAA0287    ZIM2    kr-znf3    ZNF78L1    ZNF726P1    ZFS-3
    ZNF    DKFZp666C237    ZFS-6    smap-7    DKFZp313M0722    HZF16
    ZNF138    ZNF22    ZNF323    ZSCAN21    DKFZp434J0650    ZNF697

    Find genes that share paralogs with PEG3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    9 SNPs for PEG3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355624
    A colorectal cancer sample4--see VAR_0355622 R H mis40--------
    rs360168961,2,4
    ----see VAR_0527252 mis40--------
    rs72517981,2,4
    ----see VAR_0273982 mis40--------
    rs104129321,2,4
    ----see VAR_0273992 mis40--------
    rs21914321,2,4
    ----see VAR_0273972 mis40--------
    VAR_0274004
    ----see VAR_0274002 R L mis40--------
    rs348315531,2,4
    ----see VAR_0527272 mis40--------
    rs340511331,2,4
    ----see VAR_0527282 mis40--------
    rs358518661,2,4
    ----see VAR_0527262 mis40--------

    HapMap Linkage Disequilibrium report for PEG3 (57321445 - 57352096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PEG3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833884CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PEG3
    DNA2.0 Custom Variant and Variant Library Synthesis for PEG3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601483    OMIM disorders: --

    2 diseases for PEG3:    
    About MalaCards
    undifferentiated embryonal sarcoma of the liver    embryonal sarcoma

    1 disease from the University of Copenhagen DISEASES database for PEG3:
    Beckwith-Wiedemann syndrome

    Find genes that share disorders with PEG3           About GenesLikeMe

    7 Novoseek inferred disease relationships for PEG3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 31.2 29 11398192 (5), 11260267 (5), 15141944 (5), 19367087 (4) (see all 5)
    tumors 29.3 25 15389539 (4), 15674324 (3), 10580840 (2), 12813455 (1) (see all 13)
    melanoma 29.2 1 16861924 (1)
    cancer 25.9 29 10611347 (9), 15647352 (2), 15389539 (2), 18286529 (1) (see all 11)
    growth retardation 18.4 1 10195900 (1)
    ovarian cancer 13.9 13 18286529 (8), 16023706 (1), 16646087 (1)
    necrosis 0 2 10580840 (1), 14753496 (1)

    Genetic Association Database (GAD): PEG3
    Human Genome Epidemiology (HuGE) Navigator: PEG3 (1 document)

    Export disorders for PEG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PEG3 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with PEG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. (PubMed id 9149948)1, 2, 3, 9 Kim J.... Stubbs L. (Genome Res. 1997)
    2. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. (PubMed id 11260267)1, 2, 9 Kohda T....Ishino F. (Genes Cells 2001)
    3. Paternal monoallelic expression of PEG3 in the human placenta. (PubMed id 11331620)1, 2, 9 Hiby S.E.... King A. (Hum. Mol. Genet. 2001)
    4. Structure of the SCAN domain of human paternally expressed gene 3 protein. (PubMed id 23936039)1, 2 Rimsa V.... Hunter W.N. (PLoS ONE 2013)
    5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. (PubMed id 16023706)1, 9 Dowdy S.C....Jiang S.W. (Gynecol. Oncol. 2005)
    8. Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. (PubMed id 18286529)1, 9 Feng W....Bast R.C. (Cancer 2008)
    9. Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma. (PubMed id 19367087)1, 9 Otsuka S....Nanba E. (Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 2009)
    10. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. (PubMed id 9500555)1, 9 Relaix F....Sassoon D.A. (Nat. Genet. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5178 HGNC: 8826 AceView: PEG3 Ensembl:ENSG00000198300 euGenes: HUgn5178
    ECgene: PEG3 H-InvDB: PEG3

    (According to HUGE)
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    HUGE: KIAA0287

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PEG3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PEG3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PEG3 gene:
    Search GeneIP for patents involving PEG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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