Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PEG3 Gene

protein-coding GIFtS: 57
GCID: GC19M057321

paternally expressed 3

Explore 15 diseases affiliated with
PEG3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Paternally Expressed 3¹ ²		Zinc Finger And SCAN Domain-Containing Protein 24² ³
ZSCAN24¹ ² ³		PW1²
ZKSCAN22¹ ²		Kruppel-Type Zinc Finger Protein²
ZNF904¹ ²		Paternally-Expressed Gene 3 Protein²
KIAA0287¹ ³

External Ids:	HGNC: 8826¹	Entrez Gene: 5178²	Ensembl: ENSG00000198300⁷	OMIM: 601483⁵	UniProtKB: Q9GZU2³

Export aliases for PEG3 gene to outside databases

Previous GC identifers: GC19U990074 GC19M061977 GC19M061394 GC19M062015 GC19M057288

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PEG3:

In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and

both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either

with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals

ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not

share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in

cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in

glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding

distinct isoforms. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2

Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death

pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through

activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells

Gene Wiki entry for PEG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PEG3 gene promoter:
CREB AML1a FOXF2 Sp1 deltaCREB GATA-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for PEG3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEG3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.4

PEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEG3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M057321: view genomic region (about GC identifiers)

Start:	57,285,930 bp from pter	End:	57,352,097 bp from pter
Size:	66,168 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2 (See protein sequence)

Recommended Name: Paternally-expressed gene 3 protein

Size: 1588 amino acids; 180827 Da

Subunit: Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 (By similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)

Sequence caution: Sequence=BAB85588.1; Type=Frameshift; Positions=Several; Sequence=CAI45975.1; Type=Erroneous

initiation;

Secondary accessions: A7E2B8 B4DIM4 C9JP50 P78418 Q5H9P9 Q7Z7H7 Q8TF75 Q9GZY2

Alternative splicing: 4 isoforms: Q9GZU2-1 Q9GZU2-2 Q9GZU2-3 Q9GZU2-4

Explore the universe of human proteins at neXtProt for PEG3: NX_Q9GZU2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9GZU2

PEG3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001139656.1 NP_001139657.1 NP_001139658.1 NP_001139659.1 NP_006201.1

ENSEMBL proteins:

ENSP00000375589 ENSP00000221722 ENSP00000326581 ENSP00000403051

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): PEG3 OriGene Custom Protein Services for PEG3
	GenScript Custom Purified and Recombinant Proteins Services for PEG3
	Novus Biologicals PEG3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PEG3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

PEG3 for ontologies About GeneDecksing

PEG3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PEG3
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PEG3
	GenScript Custom Superior Antibodies Services for PEG3
	Search for Antibodies for PEG3 at Abcam
	Uscn Antibodies for PEG3
	Search ThermoFisher Antibodies for PEG3

Assay Products for PEG3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PEG3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PEG3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PEG3 for domains About GeneDecksing

5 InterPro domains/families:

IPR008916 Retrov_capsid_C

IPR003309 Tscrpt_reg_SCAN

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9GZU2

ProtoNet protein and cluster: Q9GZU2

1 Blocks protein family: IPB003309 Transcriptional regulator SCAN

UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 SCAN box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2

Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death

pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through

activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells

Genatlas biochemistry entry for PEG3:

zinc finger protein,Kruppel type (C2H2) predominantly expressed in ovary,testis,placenta,murine paternally expressed

gene 3

miRNA Products:		OriGene 3'-UTR Clone (see all 5): PEG3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PEG3
		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate PEG3 (see all 63):
		hsa-miR-21* hsa-miR-100* hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-1197 hsa-miR-200a hsa-miR-3653

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEG3 (see all 4) OriGene shRNA RFP: PEG3 OriGene siRNA: PEG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEG3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PEG3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEG3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEG3 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): PEG3 (NM_006210)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PEG3
		Search LifeMap BioReagents cell lines for PEG3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

PEG3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PEG3:

Decreased viability of wild-ty

Increased circadian period len

Animal Models:
Mouse knock-out Peg3^tm1Masu for PEG3
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Peg3):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	homeostasis/metabolism
mortality/aging	nervous system

PEG3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

1 BioSystems Pathway for PEG3

TNF-alpha/NF-kB Signaling Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PEG3

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for PEG3 (Q9GZU2^{2, 3} ENSP00000326581⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USP7	Q93009²^,³, ENSP00000343535⁴	MINT-2861661 I2D: score=3 STRING: ENSP00000343535
SIAH1	Q8IUQ4³, ENSP00000349156⁴	I2D: score=2 STRING: ENSP00000349156
BRCA1	P38398³, ENSP00000350283⁴	I2D: score=1 STRING: ENSP00000350283
SIAH2	O43255³, ENSP00000322457⁴	I2D: score=2 STRING: ENSP00000322457
TRAF2	Q12933³, ENSP00000247668⁴	I2D: score=1 STRING: ENSP00000247668

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0006351	transcription, DNA-dependent	--	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006915	apoptotic process	IEA	--
GO:0016032	viral reproduction	IEA	--

PEG3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PEG3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PEG3
4 Novoseek chemical compound relationships for PEG3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
peg-10	86.3	5	17701895 (2), 16778176 (2), 15057899 (1)
5-aza-2'deoxycytidine	47.9	5	16023706 (1), 18286529 (1), 11398192 (1)
zinc	35.1	6	8563758 (2), 9149948 (1), 11260267 (1), 11161803 (1) (see all 5)
vegf	0	5	10611347 (3), 14753496 (2)

Search CenterWatch for drugs/clinical trials and news about PEG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PEG3 gene (5 alternative transcripts):

NM_001146184.1 NM_001146185.1 NM_001146186.1 NM_001146187.1 NM_006210.2

Unigene Cluster for PEG3:

Paternally expressed 3

Hs.731875 [show with all ESTs]

Unigene Representative Sequence: NM_006210

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000391708(uc002qnq.2 uc010etp.2) ENST00000221722(uc002qnr.2 uc010ygs.1)

ENST00000326441(uc002qnv.2) ENST00000423103(uc002qnt.2 uc002qnu.2 uc002qnw.2 uc002qnx.2 uc010etr.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 5): PEG3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PEG3
		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate PEG3 (see all 63):
		hsa-miR-21* hsa-miR-100* hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-1197 hsa-miR-200a hsa-miR-3653

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEG3 (see all 4) OriGene shRNA RFP: PEG3 OriGene siRNA: PEG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEG3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEG3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEG3 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): PEG3 (NM_006210)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PEG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PEG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEG3

Additional cDNA sequence:

AB003039.1 AB006625.2 AF166122.1 AF208967.1 AF208968.1 AF208969.1 AF208970.1 AK295679.1

AK307476.1 AY339615.1 BC037330.2 BC104876.1 BC104878.1 BC136268.1 BC143663.1 BC143664.1

BC150272.1 CR933682.1 U90336.1

12 DOTS entries:

DT.446793 DT.95081812 DT.101965191 DT.40222147 DT.121453297 DT.40301921 DT.97789371 DT.86854767

DT.91961833 DT.95123990 DT.99954028 DT.95358814

24/273 AceView cDNA sequences (see all 273):

AB006625 BM679614 BM967018 BI494893 AF208967 AA084286 AV708452 AA383002

BF446947 AW450648 AI926648 AA448856 BM263168 AW590551 AV708395 BX491788

H19778 T26612 AW086429 AF208970 BE139174 NM_006210 BG622420 AI143605

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PEG3 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	·	6g	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16a	·
SP1:									-		-		-		-		-		-		-																-		-		-				-
SP2:									-		-				-
SP3:									-		-		-		-		-		-		-
SP4:									-		-		-		-
SP5:									-		-		-		-		-		-		-

ExUns:	16b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PEG3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PEG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTCACCAT

About this image

PEG3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Muscle Satellite Pool

Forelimb Muscle Satellite Cells

Skeletal Muscle

Limb

Hindlimb Muscle Satellite Pool

Hindlimb Muscle Satellite Cells

Skeletal Muscle

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Skeletal Muscle

Cervical Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Lumbar Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Sacral Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Thoracic Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Kidney

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

mK4 (Cell line)

Kidney

mK3 (Cell line)

Kidney

See PEG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PEG3

SOURCE GeneReport for Unigene cluster: Hs.731875

UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2

Tissue specificity: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is

found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma

including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines

SABiosciences Custom PCR Arrays for PEG3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PEG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEG3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PEG3 gene from 2/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Peg3^{1 , 5}	paternally expressed 3^{1, 5}	71.5(n)¹ 64.78(a)¹		7 (3.89 cM)⁵ 18616¹ NM_008817.2¹ NP_032843.2¹ 6703892⁵
African clawed frog (Xenopus laevis)	Amphibia	BQ884395.1²	--	81.44(n)		BQ884395.1

ENSEMBL Gene Tree for PEG3 (if available)
TreeFam Gene Tree for PEG3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79174259^1,2		--	53630552(+)	`CAAGAG/CTCAGG`	8	--	ds500¹ int¹		1		WA	118
rs202223891^1,2	C	--	53630963(+)	`TTTAAC/TTTTAT`	8	--	ut3¹ int¹		0	--	--	--	--
rs10407687^1,2	C,F,H,	--	53631139(+)	`TTTCTA/GTAATG`	8	--	ut3¹ int¹		5		NS EA WA	538
rs73626608^1,2	C,	--	53631240(+)	`TAACCA/GTAATC`	8	--	ut3¹ int¹		2		WA	120
rs77039306^1,2	C,	--	53631619(+)	`ACAAGC/TGTGTG`	8	--	ut3¹ int¹		2		WA	120
rs28648863^1,2	F,	--	53631756(+)	`CACCAA/GTGGAG`	8	--	ut3¹ int¹		1		WA	118
rs11666110^1,2	C,F,H,	--	53632258(+)	`TACTTT/CCGTGT`	8	--	ut3¹ int¹		15		NS EA NA	1904
rs78174116^1,2		--	53632299(+)	`ATATTA/TCCACG`	8	--	ut3¹ int¹		0	--	--	--	--
rs12980845^1,2	H	--	53632352(+)	`AAGTGT/CCCACA`	8	--	ut3¹ int¹		4		NS EA	420
rs8103783^1,2	C,F,H,	--	53632685(+)	`CACCCC/TGCTCA`	8	--	ut3¹ int¹		5		NS EA WA	538

HapMap Linkage Disequilibrium report for PEG3 (57285930 - 57352097 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PEG3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PEG3

DNA2.0 Custom Variant and Variant Library Synthesis for PEG3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PEG3 for disorders           About GeneDecksing

OMIM gene information: 601483    OMIM disorders: --

15 diseases for PEG3:    About MalaCards

beckwith-wiedemann syndrome biliary atresia angelman syndrome ovarian cancer

prostate adenocarcinoma breast carcinoma melanoma adenocarcinoma

glioblastoma ataxia neuroblastoma prostatitis

carcinoma pancreatitis neuronitis

1 disease from the University of Copenhagen DISEASES database for PEG3:

Beckwith-Wiedemann syndrome

7 Novoseek disease relationships for PEG3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glioma	31.2	29	11398192 (5), 11260267 (5), 15141944 (5), 19367087 (4) (see all 5)
tumors	29.3	25	15389539 (4), 15674324 (3), 10580840 (2), 12813455 (1) (see all 13)
melanoma	29.2	1	16861924 (1)
cancer	25.9	29	10611347 (9), 15647352 (2), 15389539 (2), 18286529 (1) (see all 11)
growth retardation	18.4	1	10195900 (1)
ovarian cancer	13.9	13	18286529 (8), 16023706 (1), 16646087 (1)
necrosis	0	2	10580840 (1), 14753496 (1)

Human Genome Epidemiology (HuGE) Navigator: PEG3 (1 document)

Export disorders for PEG3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PEG3 gene, integrated from 9 sources (see all 83):
(articles sorted by number of sources associating them with PEG3)

Utopia: connect your pdf to the dynamic
world of online information

The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. (PubMed id 9149948)^{1, 2, 3, 9} Kim J.... Stubbs L. (1997)
Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. (PubMed id 11260267)^{1, 2, 9} Kohda T....Ishino F. (2001)
Paternal monoallelic expression of PEG3 in the human placenta. (PubMed id 11331620)^{1, 2, 9} Hiby S.E.... King A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. (PubMed id 16023706)^{1, 9} Dowdy S.C....Jiang S.W. (2005)
Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. (PubMed id 18286529)^{1, 9} Feng W....Bast R.C. (2008)
Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma. (PubMed id 19367087)^{1, 9} Otsuka S....Nanba E. (2009)
Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. (PubMed id 9500555)^{1, 9} Relaix F....Sassoon D.A. (1998)
The imprinted gene PEG3 inhibits Wnt signaling and re gulates glioma growth. (PubMed id 20064927)^{1, 9} Jiang X....Johnson M.D. (2010)
DNA methylation analysis of the mammalian PEG3 imprin ted domain. (PubMed id 19397955)^{1, 9} Huang J.M. and Kim J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5178	HGNC: 8826	AceView: PEG3	Ensembl:ENSG00000198300	euGenes: HUgn5178
ECgene: PEG3	H-InvDB: PEG3

(According to HUGE)
About This Section

HUGE: KIAA0287

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PEG3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PEG3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PEG3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PEG3 gene:
Search GeneIP for patents involving PEG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of PEG3
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for PEG3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PEG3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PEG3
	OriGene Protein Over-expression Lysate for PEG3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PEG3		OriGene 3'-UTR Clone for PEG3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PEG3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PEG3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PEG3		OriGene Custom Protein Services for PEG3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PEG3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PEG3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEG3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEG3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEG3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PEG3

	GenScript Custom Purified and Recombinant Proteins Services for PEG3		GenScript cDNA clones with any tag delivered in your preferred vector for PEG3
	GenScript Custom Assay Services for PEG3		GenScript Custom Superior Antibodies Services for PEG3
	GenScript Custom overexpressing Cell Line Services for PEG3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PEG3 promoter
	Search Chromatin IP Primers for PEG3
	RT² qPCR Primer Assay in human, mouse, rat PEG3
	GNC Network for PEG3
	SABiosciences Custom PCR Arrays for PEG3

Search Tocris compounds for PEG3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PEG3 lysates

	Search for Antibodies for PEG3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for PEG3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

PEG3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for PEG3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG3

	Browse SwitchGear 3'UTR luciferase reporter plasmids for PEG3
	Browse SwitchGear Promoter luciferase reporter plasmids for PEG3

Search ThermoFisher Antibodies for PEG3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PEG3 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

PEG3 Gene

paternally expressed 3

Aliases
for PEG3 gene

Summaries
for PEG3 gene

Genomic Views
for PEG3 gene

Proteins
for PEG3 gene

Protein Domains /
Families
for PEG3 gene

Function
for PEG3 gene

Pathways & Interactions
for PEG3 gene

Drugs & Compounds
for PEG3 gene

Transcripts
for PEG3 gene

Expression
for PEG3 gene

Orthologs
for PEG3 gene

Paralogs
for PEG3 gene

Genomic Variants
for PEG3 gene

Disorders / Diseases
for PEG3 gene

Publications
for PEG3 gene

External Searches for PEG3 gene

Genome Databases showing PEG3 gene

Other Databases showing PEG3 gene

Specialized Databases showing PEG3 gene

Intellectual Property
for PEG3 gene

Products
for PEG3 gene

View Random Gene

Advanced Search

Export list of displayed genes

PEG3 Gene

paternally expressed 3

Aliasesfor PEG3 gene

Summariesfor PEG3 gene

Genomic Viewsfor PEG3 gene

Proteinsfor PEG3 gene

Protein Domains /Familiesfor PEG3 gene

Functionfor PEG3 gene

Pathways & Interactionsfor PEG3 gene

Drugs & Compoundsfor PEG3 gene

Transcriptsfor PEG3 gene

Expression for PEG3 gene

Orthologsfor PEG3 gene

Paralogsfor PEG3 gene

Genomic Variantsfor PEG3 gene

Disorders / Diseasesfor PEG3 gene

Publicationsfor PEG3 gene

External Searches for PEG3 gene

Genome Databases showing PEG3 gene

Other Databases showing PEG3 gene

Specialized Databases showing PEG3 gene

Intellectual Propertyfor PEG3 gene

Productsfor PEG3 gene

View Random Gene

Aliases
for PEG3 gene

Summaries
for PEG3 gene

Genomic Views
for PEG3 gene

Proteins
for PEG3 gene

Protein Domains /
Families
for PEG3 gene

Function
for PEG3 gene

Pathways & Interactions
for PEG3 gene

Drugs & Compounds
for PEG3 gene

Transcripts
for PEG3 gene

Expression
for PEG3 gene

Orthologs
for PEG3 gene

Paralogs
for PEG3 gene

Genomic Variants
for PEG3 gene

Disorders / Diseases
for PEG3 gene

Publications
for PEG3 gene

Intellectual Property
for PEG3 gene

Products
for PEG3 gene