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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PEG3 Gene

protein-coding   GIFtS: 60
GCID: GC19M057321

Paternally Expressed 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Paternally Expressed 31 2     ZNF9042
Zinc Finger And SCAN Domain-Containing Protein 242 3     Kruppel-Type Zinc Finger Protein2
ZSCAN242 3     Paternally-Expressed Gene 3 Protein2
PW12     KIAA02873
ZKSCAN222     

External Ids:    HGNC: 88261   Entrez Gene: 51782   Ensembl: ENSG000001983007   OMIM: 6014835   UniProtKB: Q9GZU23   

Export aliases for PEG3 gene to outside databases

Previous GC identifers: GC19U990074 GC19M061977 GC19M061394 GC19M062015 GC19M057288


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PEG3 Gene:
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common
promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their
shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3.
In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as
well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger
protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor
suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results
in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Sep 2009)

GeneCards Summary for PEG3 Gene: 
PEG3 (paternally expressed 3) is a protein-coding gene. Diseases associated with PEG3 include biliary atresia, and beckwith-wiedemann syndrome. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and nucleic acid binding. An important paralog of this gene is ZNF623.

UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2
Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal
death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis
through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells

Gene Wiki entry for PEG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PEG3 gene promoter:
         CREB   AML1a   FOXF2   Sp1   deltaCREB   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PEG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PEG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.4

PEG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEG3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M057321:  view genomic region     (about GC identifiers)

Start:
57,321,445 bp from pter      End:
57,352,096 bp from pter
Size:
30,652 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2 (See protein sequence)
Recommended Name: Paternally-expressed gene 3 protein  
Size: 1588 amino acids; 180827 Da
Subunit: Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)
Sequence caution: Sequence=BAB85588.1; Type=Frameshift; Positions=Several; Sequence=CAI45975.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for PEG3:
4BHX (3D)    
Secondary accessions: A7E2B8 B4DIM4 C9JP50 P78418 Q5H9P9 Q7Z7H7 Q8TF75 Q9GZY2
Alternative splicing: 4 isoforms:  Q9GZU2-1   Q9GZU2-2   Q9GZU2-3   Q9GZU2-4   

Explore the universe of human proteins at neXtProt for PEG3: NX_Q9GZU2

Explore proteomics data for PEG3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZU2

  • PEG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PEG3 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001139656.1  NP_001139657.1  NP_001139658.1  NP_001139659.1  NP_006201.1  

    ENSEMBL proteins: 
     ENSP00000326581   ENSP00000473190   ENSP00000472402   ENSP00000472395   ENSP00000469486  
     ENSP00000470467   ENSP00000469144   ENSP00000403051  

    Human Recombinant Protein Products for PEG3: 
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    OriGene Protein Over-expression Lysate for PEG3
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    Novus Biologicals PEG3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PEG3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    PEG3 for ontologies           About GeneDecksing



    PEG3 Antibody Products: 
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    GenScript Custom Superior Antibodies Services for PEG3
    Search for Antibodies for PEG3 at Abcam
    Cloud-Clone Corp. Antibodies for PEG3 
    Search ThermoFisher Antibodies for PEG3
    LSBio Antibodies in human, mouse, rat for PEG3 

    Assay Products for PEG3: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PEG3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PEG3 
    Cloud-Clone Corp. CLIAs for PEG3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9GZU2

    ProtoNet protein and cluster: Q9GZU2

    1 Blocks protein domain: IPB003309 Transcriptional regulator SCAN

    UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 SCAN box domain


    PEG3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PEG3_HUMAN, Q9GZU2
    Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal
    death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis
    through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells

         Genatlas biochemistry entry for PEG3:
    zinc finger protein,Kruppel type (C2H2) predominantly expressed in ovary,testis,placenta,murine paternally
    expressed gene 3

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    PEG3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PEG3:
     Decreased viability of wild-ty  Increased circadian period len 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Peg3):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging  nervous system 

    PEG3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Peg3tm1Masu for PEG3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PEG3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PEG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PEG3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PEG3 

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 5): PEG3 (NM_006210)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PEG3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for PEG3
        TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PEG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for PEG3 (Q9GZU22, 3 ENSP000003265814) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930092, 3, ENSP000003435354MINT-2861661 I2D: score=3 STRING: ENSP00000343535
    SIAH1Q8IUQ43, ENSP000003491564I2D: score=2 STRING: ENSP00000349156
    BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
    SIAH2O432553, ENSP000003224574I2D: score=2 STRING: ENSP00000322457
    TRAF2Q129333, ENSP000002476684I2D: score=1 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0006915apoptotic process IEA--

    PEG3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PEG3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PEG3

    4 Novoseek inferred chemical compound relationships for PEG3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peg-10 86.3 5 17701895 (2), 16778176 (2), 15057899 (1)
    5-aza-2'deoxycytidine 47.9 5 16023706 (1), 18286529 (1), 11398192 (1)
    zinc 35.1 6 8563758 (2), 9149948 (1), 11260267 (1), 11161803 (1) (see all 5)
    vegf 0 5 10611347 (3), 14753496 (2)

    Search CenterWatch for drugs/clinical trials and news about PEG3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PEG3 gene (5 alternative transcripts): 
    NM_001146184.1  NM_001146185.1  NM_001146186.1  NM_001146187.1  NM_006210.2  

    Unigene Cluster for PEG3:

    Paternally expressed 3
    Hs.731875  [show with all ESTs]
    Unigene Representative Sequence: NM_006210
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326441(uc002qnv.2) ENST00000599565 ENST00000598410 ENST00000593695
    ENST00000599534 ENST00000599577 ENST00000600833 ENST00000596261 ENST00000594706
    ENST00000594389 ENST00000423103(uc002qnt.2 uc002qnu.2 uc002qnw.2 uc002qnx.2 uc010etr.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate PEG3 (see all 63):
    hsa-miR-21* hsa-miR-100* hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-1197 hsa-miR-200a hsa-miR-3653
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PEG3
    Clone
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    OriGene ORF clones in mouse, rat for PEG3
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    GenScript: all cDNA clones in your preferred vector (see all 5): PEG3 (NM_006210)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PEG3
    Primer
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    Additional mRNA sequence: 

    AB003039.1 AB006625.2 AF166122.1 AF208967.1 AF208968.1 AF208969.1 AF208970.1 AK295679.1 
    AK307476.1 AY339615.1 BC037330.2 BC104876.1 BC104878.1 BC136268.1 BC143663.1 BC143664.1 
    BC150272.1 CR933682.1 U90336.1 

    12 DOTS entries:

    DT.446793  DT.95081812  DT.101965191  DT.40222147  DT.121453297  DT.40301921  DT.97789371  DT.86854767 
    DT.91961833  DT.95123990  DT.99954028  DT.95358814 

    24/273 AceView cDNA sequences (see all 273):

    BG622420 BF732186 AI693079 AF208968 BX491788 AW450648 BI494893 AI143605 
    H19778 BM967018 BF446947 BE502379 AA580928 AI174652 AA383002 AA033956 
    AA460030 AA350686 BM697482 AF166122 BU753605 AV708452 AI926648 AI609061 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PEG3 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                          -     -     -     -     -     -     -                                               -     -     -           -                     
    SP2:                          -     -           -                                                                                                               
    SP3:                          -     -     -     -     -     -     -                                                                                             
    SP4:                          -     -     -     -                                                                                                               
    SP5:                          -     -     -     -     -     -     -                                                                                             

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for PEG3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PEG3 expression in normal human tissues (normalized intensities)      PEG3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCACCAT
    PEG3 Expression
    About this image


    PEG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             Caudate nucleus   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Muscle Satellite Cells Lumbar Muscle Satellite Pool
             Extraocular Muscles
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Interstitial Stroma
             mK3
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Adrenal Gland (Endocrine System)
             Adrenal Cortex   

    See PEG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PEG3

    SOURCE GeneReport for Unigene cluster: Hs.731875

    UniProtKB/Swiss-Prot: PEG3_HUMAN, Q9GZU2
    Tissue specificity: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it
    is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian
    stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines

        SABiosciences Custom PCR Arrays for PEG3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PEG3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PEG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PEG3 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Peg31 , 5 paternally expressed 31, 5 71.5(n)1
    64.78(a)1
      7 (3.89 cM)5
    186161  NM_008817.21  NP_032843.21 
     67038925 
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ884395.12   -- 81.44(n)    BQ884395.1 


    ENSEMBL Gene Tree for PEG3 (if available)
    TreeFam Gene Tree for PEG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PEG3 gene
    ZNF6232  
    18/43 SIMAP similar genes for PEG3 using alignment to 5 protein entries:     PEG3_HUMAN (see all proteins) (see all similar genes):
    KIAA0287    ZIM2    kr-znf3    ZNF78L1    ZNF726P1    ZFS-3
    ZNF    ZNF663    DKFZp666C237    ZFS-6    smap-7    DKFZp313M0722
    HZF16    ZNF138    ZNF22    ZNF323    ZSCAN21    DKFZp434J0650

    PEG3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    9 SNPs in PEG3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355624
    A colorectal cancer sample4--see VAR_0355622 R H mis40--------
    VAR_0527254
    ----see VAR_0527252 E G mis40--------
    VAR_0273984
    ----see VAR_0273982 V L mis40--------
    VAR_0273994
    ----see VAR_0273992 D G mis40--------
    VAR_0273974
    ----see VAR_0273972 A T mis40--------
    VAR_0274004
    ----see VAR_0274002 R L mis40--------
    VAR_0527274
    ----see VAR_0527272 A V mis40--------
    VAR_0527284
    ----see VAR_0527282 R H mis40--------
    VAR_0527264
    ----see VAR_0527262 N S mis40--------

    HapMap Linkage Disequilibrium report for PEG3 (57321445 - 57352096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PEG3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833884CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601483    OMIM disorders: --

    12 diseases for PEG3:    About MalaCards
    biliary atresia    beckwith-wiedemann syndrome    prostate adenocarcinoma    angelman syndrome
    ovarian cancer    glioblastoma    melanoma    neuroblastoma
    adenocarcinoma    prostatitis    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PEG3:
    Beckwith-Wiedemann syndrome

    PEG3 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for PEG3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 31.2 29 11398192 (5), 11260267 (5), 15141944 (5), 19367087 (4) (see all 5)
    tumors 29.3 25 15389539 (4), 15674324 (3), 10580840 (2), 12813455 (1) (see all 13)
    melanoma 29.2 1 16861924 (1)
    cancer 25.9 29 10611347 (9), 15647352 (2), 15389539 (2), 18286529 (1) (see all 11)
    growth retardation 18.4 1 10195900 (1)
    ovarian cancer 13.9 13 18286529 (8), 16023706 (1), 16646087 (1)
    necrosis 0 2 10580840 (1), 14753496 (1)

    Genetic Association Database (GAD): PEG3
    Human Genome Epidemiology (HuGE) Navigator: PEG3 (1 document)

    Export disorders for PEG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PEG3 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with PEG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. (PubMed id 9149948)1, 2, 3, 9 Kim J.... Stubbs L. (1997)
    2. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. (PubMed id 11260267)1, 2, 9 Kohda T....Ishino F. (2001)
    3. Paternal monoallelic expression of PEG3 in the human placenta. (PubMed id 11331620)1, 2, 9 Hiby S.E.... King A. (2001)
    4. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. (PubMed id 16023706)1, 9 Dowdy S.C....Jiang S.W. (2005)
    7. Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. (PubMed id 18286529)1, 9 Feng W....Bast R.C. (2008)
    8. Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma. (PubMed id 19367087)1, 9 Otsuka S....Nanba E. (2009)
    9. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. (PubMed id 9500555)1, 9 Relaix F....Sassoon D.A. (1998)
    10. The imprinted gene PEG3 inhibits Wnt signaling and re gulates glioma growth. (PubMed id 20064927)1, 9 Jiang X....Johnson M.D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5178 HGNC: 8826 AceView: PEG3 Ensembl:ENSG00000198300 euGenes: HUgn5178
    ECgene: PEG3 H-InvDB: PEG3

    (According to HUGE)
    About This Section
    HUGE: KIAA0287

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PEG3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PEG3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PEG3 gene:
    Search GeneIP for patents involving PEG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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